[ { "uniprot_canonical_ac": "P10683-1", "uniprot_id": [ { "id": "GALA_RAT", "url": "https://www.uniprot.org/uniprot/P10683", "type": "external" } ], "mass": 13328.0, "length": 124, "protein_name": "Galanin peptides", "gene_name": "Gal", "organism": "Rat", "refseq_name": "galanin peptides preproprotein", "refseq_ac": [ { "id": "NP_150240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_150240", "type": "external" } ], "gene_names_uniprotkb": "Gal; Galn", "gene_names_refseq": "Galn; Gal", "protein_names_uniprotkb": "Galanin peptides", "protein_names_refseq": "galanin peptides preproprotein; galanin peptides; galanin prepropeptide; galanin/GMAP prepropeptide", "tax_id": 10116, "disease": "familial temporal lobe epilepsy 8 (Disease Ontology:DOID:0060754); hypertension (Disease Ontology:DOID:10763); mononeuropathy (Disease Ontology:DOID:1188); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); opiate dependence (Disease Ontology:DOID:2559); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29141); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "2445750;2448788;29127424;33044017;33212101;34497682", "class_list": "", "function": "Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion., [UniProtKB, UniProtKB, UniProtKB]; Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus., [RefSeq, PubMed]; Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats. Publication Status: Online-Only, [RefSeq, PubMed]; Novel Role of miR-18a-5p and Galanin in Rat Lung Ischemia Reperfusion-Mediated Response. Publication Status: Online-Only, [RefSeq, PubMed]; UVB irradiation induces contralateral changes in galanin, substance P and c-fos immunoreactivity in rat dorsal root ganglia, dorsal horn and lateral spinal nucleus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0031763 galanin receptor binding;GO:0004966 galanin receptor activity;GO:0031764 type 1 galanin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0044306 neuron projection terminus", "go_biological_process": "GO:0090274 positive regulation of somatostatin secretion;GO:0060746 parental behavior;GO:0031943 regulation of glucocorticoid metabolic process;GO:0007165 signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10683-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10715-1", "uniprot_id": [ { "id": "CYC2_RAT", "url": "https://www.uniprot.org/uniprot/P10715", "type": "external" } ], "mass": 11743.0, "length": 105, "protein_name": "Cytochrome c, testis-specific", "gene_name": "Cyct; Pde11a", "organism": "Rat", "refseq_name": "cytochrome c, testis-specific", "refseq_ac": [ { "id": "NP_036972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036972", "type": "external" } ], "gene_names_uniprotkb": "Cyct; Pde11a; Cyct", "gene_names_refseq": "CYCTA; Cyct", "protein_names_uniprotkb": "Cytochrome c, testis-specific", "protein_names_refseq": "Cytochrome C testis specific; cytochrome c, testis-specific", "tax_id": 10116, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); primary pigmented nodular adrenocortical disease 2 (Disease Ontology:DOID:0070547); advanced sleep phase syndrome 2 (Disease Ontology:DOID:0110012); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); thrombocytopenia (Disease Ontology:DOID:1588); colon cancer (Disease Ontology:DOID:219); hyperglycemia (Disease Ontology:DOID:4195)", "pathway": " (rno:25310)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14680842;2834389", "class_list": "", "function": "Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain., [UniProtKB]; Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity)., [UniProtKB]; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively., [UniProtKB, UniProtKB]; These findings suggest that heat stress of testes triggers the release of cytochrome c from mitochondria in spermatogenic cells, leading to the activation of an apoptotic pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006915 apoptotic process;GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0042743 hydrogen peroxide metabolic process;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P10715-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10758-1", "uniprot_id": [ { "id": "LITH_RAT", "url": "https://www.uniprot.org/uniprot/P10758", "type": "external" } ], "mass": 18672.0, "length": 165, "protein_name": "Lithostathine", "gene_name": "Reg1", "organism": "Rat", "refseq_name": "lithostathine precursor", "refseq_ac": [ { "id": "NP_036773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036773", "type": "external" } ], "gene_names_uniprotkb": "Reg1; Reg", "gene_names_refseq": "LITHOST; RATLITHOST; RATRGPI; RGPI; Reg1a; Reg1; Reg; Rgp1", "protein_names_uniprotkb": "Lithostathine; ICRF; Islet cells regeneration factor; Islet of Langerhans regenerating protein; PSP; PTP; Pancreatic stone protein; Pancreatic thread protein; REG", "protein_names_refseq": "ICRF; PSP; PTP; islet cells regeneration factor; islet of Langerhans regenerating protein; lithostathine precursor; lithostathine; pancreatic stone protein; pancreatic thread protein; regenerating islet-derived 1 alpha; regenerating islet-derived mouse homolog 1; regeneration protein, lithostatin, pancreatic stone protein", "tax_id": 10116, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); Alzheimer's disease (Disease Ontology:DOID:10652); Sjogren's syndrome (Disease Ontology:DOID:12894); colon cancer (Disease Ontology:DOID:219); cholangiocarcinoma (Disease Ontology:DOID:4947); myocardial infarction (Disease Ontology:DOID:5844); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24714)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "1985964;23954444;24465846;2680252;28415799;29537200;2963000;7916640", "class_list": "", "function": "Alox15 mRNA levels were 4 times higher in iron-deficient than in iron-adequate pancreas and that Reg1a, Reg3a, and Reg3b mRNA levels were 17-36 times higher in iron-overloaded pancreas. Publication Status: Online-Only, [RefSeq, PubMed]; Might act as an inhibitor of spontaneous calcium carbonate precipitation., [UniProtKB]; The pancreas reacts to remote lesions and septic insults in mice and rats with increased PSP synthesis, while PAP is selectively responsive to septic events. Furthermore, our results suggest that serum PSP in septic patients is predominantly derived through an acute phase response of the pancreas., [RefSeq, PubMed]; The positive correlation between Reg1a and Tgfb1 genes expression was determined in the dynamics of stress-induced gastric lesions development and healing, which may indicate the involvement of Tgfb1 in acceleration of lesions healing., [RefSeq, PubMed]; These results strongly suggest that the combined stimulation of IL-6 and glucocorticoids induces the activation of both Reg and HGF genes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0030246 carbohydrate binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005615 extracellular space;GO:0030426 growth cone;GO:0045178 basal part of cell;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:1904699 positive regulation of acinar cell proliferation;GO:1990798 pancreas regeneration;GO:1990864 response to growth hormone-releasing hormone;GO:1990878 cellular response to gastrin", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10758-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10818-1", "uniprot_id": [ { "id": "CX6A1_RAT", "url": "https://www.uniprot.org/uniprot/P10818", "type": "external" } ], "mass": 12301.0, "length": 111, "protein_name": "Cytochrome c oxidase subunit 6A1, mitochondrial", "gene_name": "Cox6a1", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 6A1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_036946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036946", "type": "external" } ], "gene_names_uniprotkb": "Cox6a1; Cox6al", "gene_names_refseq": "COX6AL; Cox6a1", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6A1, mitochondrial; Cytochrome c oxidase polypeptide VIa-liver", "protein_names_refseq": "Cytochrome c oxidase subunit VIa (liver); cytochrome c oxidase polypeptide VIa-liver; cytochrome c oxidase subunit 6A1, mitochondrial precursor; cytochrome c oxidase subunit 6A1, mitochondrial; cytochrome c oxidase, subunit VIa, polypeptide 1", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease recessive intermediate D (Disease Ontology:DOID:0110203); delayed sleep phase syndrome (Disease Ontology:DOID:0111141); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (rno:25282); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "2153407;2461293;29393594;7601105;8144025", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P10818-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11510-1", "uniprot_id": [ { "id": "CP2CC_RAT", "url": "https://www.uniprot.org/uniprot/P11510", "type": "external" } ], "mass": 55919.0, "length": 490, "protein_name": "Cytochrome P450 2C12, female-specific", "gene_name": "Cyp2c12", "organism": "Rat", "refseq_name": "cytochrome P450 2C12, female-specific", "refseq_ac": [ { "id": "NP_113760", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113760", "type": "external" } ], "gene_names_uniprotkb": "Cyp2c12; Cyp2c-12; Cyp2c40; LOC100361492", "gene_names_refseq": "Cyp2c12; Cyp2c40; P450pb1; RATP4515B2; RATP4515B8", "protein_names_uniprotkb": "Cytochrome P450 2C12, female-specific; 1.14.14.1; CYPIIC12; Cytochrome P450 15-beta; Cytochrome P450-UT-1; Cytochrome P450-UT-I; Cytochrome P450I", "protein_names_refseq": "15-beta; CYPIIC12; Cytochrom P450 15-beta; P450-UT-I; P450I; UT-1; cytochrome P450 15-beta; cytochrome P450 2C12, female-specific; cytochrome P450, 2c40; cytochrome P450, family 2, subfamily c, polypeptide 40; cytochrome P450-UT-1; cytochrome P450-UT-I; cytochrome P450I", "tax_id": 10116, "disease": "renal hypertension (Disease Ontology:DOID:1073); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:25011)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15661834;2837761;3164963", "class_list": "", "function": "Gender-related expression results from the inaccessibility of STAT5 to the GH-responsive element in male, [RefSeq, PubMed]; This P450 is active in 15-beta-hydroxylation of steroid sulfates., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P11510-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11662-1", "uniprot_id": [ { "id": "NU2M_RAT", "url": "https://www.uniprot.org/uniprot/P11662", "type": "external" } ], "mass": 38653.0, "length": 346, "protein_name": "NADH-ubiquinone oxidoreductase chain 2", "gene_name": "Mt-nd2", "organism": "Rat", "refseq_name": "NADH dehydrogenase subunit 2", "refseq_ac": [ { "id": "YP_665630", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_665630", "type": "external" } ], "gene_names_uniprotkb": "Mt-nd2; Nd2", "gene_names_refseq": "ND2", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 2; 7.1.1.2; NADH dehydrogenase subunit 2", "protein_names_refseq": "NADH dehydrogenase subunit 2", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); myocardial infarction (Disease Ontology:DOID:5844); mitochondrial metabolism disease (Disease Ontology:DOID:700); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (rno:26194); (R-RNO-5419276); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "2504926;6300770", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0001666 response to hypoxia;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0072593 reactive oxygen species metabolic process;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P11662-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11950-1", "uniprot_id": [ { "id": "CX6C1_RAT", "url": "https://www.uniprot.org/uniprot/P11950", "type": "external" } ], "mass": 8553.0, "length": 76, "protein_name": "Cytochrome c oxidase subunit 6C-1", "gene_name": "Cox6c1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cox6c1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6C-1; Cytochrome c oxidase polypeptide VIc-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2836143;7601105", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P11950-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11951-1", "uniprot_id": [ { "id": "CX6C2_RAT", "url": "https://www.uniprot.org/uniprot/P11951", "type": "external" } ], "mass": 8455.0, "length": 76, "protein_name": "Cytochrome c oxidase subunit 6C-2", "gene_name": "Cox6c2", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 6C-2", "refseq_ac": [ { "id": "NP_062233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062233", "type": "external" } ], "gene_names_uniprotkb": "Cox6c2; Cox6c", "gene_names_refseq": "COVIc; COX-VIc; Cox6c2; Cox6c", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6C-2; Cytochrome c oxidase polypeptide VIc-2", "protein_names_refseq": "cytochrome c oxidase polypeptide VIc-2; cytochrome c oxidase subunit 6C-2; cytochrome c oxidase, subunit VIc; cytochrome oxidase subunit VIc", "tax_id": 10116, "disease": "cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (rno:54322); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "22673903;26446791;27213235;2822403;2836143;2854406;29393594;6200111;7601105", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63703", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P11951-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12843-1", "uniprot_id": [ { "id": "IBP2_RAT", "url": "https://www.uniprot.org/uniprot/P12843", "type": "external" } ], "mass": 32855.0, "length": 304, "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "Igfbp2", "organism": "Rat", "refseq_name": "insulin-like growth factor-binding protein 2 precursor", "refseq_ac": [ { "id": "NP_037254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037254", "type": "external" } ], "gene_names_uniprotkb": "Igfbp2; Igfbp-2", "gene_names_refseq": "BRL-BP; IBP-2; IGFBP-2; ILGFBPA; Igfbp2", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 2; BRL-BP; IBP-2; IGF-binding protein 2; IGFBP-2", "protein_names_refseq": "IGF-binding protein 2; insulin-like growth factor-binding protein 2 precursor", "tax_id": 10116, "disease": "estrogen-receptor negative breast cancer (Disease Ontology:DOID:0060076); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); methemoglobinemia (Disease Ontology:DOID:10783); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25662); (R-RNO-381426)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "2426267;24352370;2477691;2480123;2538475;2974285;39412224", "class_list": "", "function": "Insulin-Like Growth Factor Binding Protein 2 Drives Neurodegeneration in Parkinson's Disease: Insights From In Vivo and In Vitro Studies., [RefSeq, PubMed]; Insulin-like growth factor 2 (IGF2) is an important regulator of fetal growth., [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q569C7", "ec_number_list": [], "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding;GO:0141069 receptor ligand inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0051384 response to glucocorticoid;GO:0007565 female pregnancy;GO:0009612 response to mechanical stimulus;GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P12843-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12938-1", "uniprot_id": [ { "id": "CP2D3_RAT", "url": "https://www.uniprot.org/uniprot/P12938", "type": "external" } ], "mass": 56642.0, "length": 500, "protein_name": "Cytochrome P450 2D3", "gene_name": "Cyp2d3", "organism": "Rat", "refseq_name": "cytochrome P450 2D3", "refseq_ac": [ { "id": "NP_775116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775116", "type": "external" } ], "gene_names_uniprotkb": "Cyp2d3; Cyp2d-3", "gene_names_refseq": "Cyp2d13; Cyp2d3; Cyp2d6", "protein_names_uniprotkb": "Cytochrome P450 2D3; 1.14.14.1; CYPIID3; Cytochrome P450-DB3; Debrisoquine 4-hydroxylase", "protein_names_refseq": "CYPIID3; Cytochrome P450, subfamily IID3; P450-DB3; cytochrome P450 2D3; cytochrome P450, family 2, subfamily d, polypeptide 13; cytochrome P450, family 2, subfamily d, polypeptide 6; cytochrome P450-DB3; debrisoquine 4-hydroxylase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hypertrophic cardiomyopathy 12 (Disease Ontology:DOID:0110318); dilated cardiomyopathy 1M (Disease Ontology:DOID:0110449); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); extrapyramidal and movement disease (Disease Ontology:DOID:13839); major depressive disorder (Disease Ontology:DOID:1470); autoimmune hepatitis (Disease Ontology:DOID:2048); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); congestive heart failure (Disease Ontology:DOID:6000); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:24303)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2107330;2819073;9434752", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35106;Q5FVU3", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001889 liver development;GO:0006805 xenobiotic metabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P12938-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12939-1", "uniprot_id": [ { "id": "CP2DA_RAT", "url": "https://www.uniprot.org/uniprot/P12939", "type": "external" } ], "mass": 57076.0, "length": 504, "protein_name": "Cytochrome P450 2D10", "gene_name": "Cyp2d10", "organism": "Rat", "refseq_name": "cytochrome P450 2D10", "refseq_ac": [ { "id": "NP_775426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775426", "type": "external" } ], "gene_names_uniprotkb": "Cyp2d10; Cyp2d-10; Cyp2d5", "gene_names_refseq": "Cyp2d10; Cyp2d5", "protein_names_uniprotkb": "Cytochrome P450 2D10; 1.14.14.1; CYPIID10; Cytochrome P450-CMF1B; Cytochrome P450-DB5; Debrisoquine 4-hydroxylase", "protein_names_refseq": "CYPIID10; P450-CMF1B; P450-DB5; cytochrome P450 2D10; cytochrome P450, family 2, subfamily d, polypeptide 10; cytochrome P450-CMF1B; cytochrome P450-DB5; cytochrome P450CMF1b; debrisoquine 4-hydroxylase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); extrapyramidal and movement disease (Disease Ontology:DOID:13839); major depressive disorder (Disease Ontology:DOID:1470); autoimmune hepatitis (Disease Ontology:DOID:2048); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:286963)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "2107330;24098488;2771656;2819073;3190674", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P12939-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13109-1", "uniprot_id": [ { "id": "FGF2_RAT", "url": "https://www.uniprot.org/uniprot/P13109", "type": "external" } ], "mass": 17139.0, "length": 154, "protein_name": "Fibroblast growth factor 2", "gene_name": "Fgf2", "organism": "Rat", "refseq_name": "fibroblast growth factor 2", "refseq_ac": [ { "id": "NP_062178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062178", "type": "external" } ], "gene_names_uniprotkb": "Fgf2; Fgf-2", "gene_names_refseq": "Fgf-2; Fgf2a; Fgf2; bFGF", "protein_names_uniprotkb": "Fibroblast growth factor 2; Basic fibroblast growth factor; FGF-2; HBGF-2; Heparin-binding growth factor 2; bFGF", "protein_names_refseq": "HBGF-2; angiogenesis promoting growth factor; basic fibroblast growth factor; fibroblast growth factor 2a; fibroblast growth factor 2; heparin binding growth factor; heparin-binding growth factor 2", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); bone disease (Disease Ontology:DOID:0080001); COVID-19 (Disease Ontology:DOID:0080600); Parkinsonism (Disease Ontology:DOID:0080855); multiple endocrine neoplasia type 1 (Disease Ontology:DOID:10017); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); corneal neovascularization (Disease Ontology:DOID:11382); leiomyoma (Disease Ontology:DOID:127); endometrial cancer (Disease Ontology:DOID:1380); cognitive disorder (Disease Ontology:DOID:1561); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526); transitional cell carcinoma (Disease Ontology:DOID:2671); dermatitis (Disease Ontology:DOID:2723); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); bladder disease (Disease Ontology:DOID:365); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); cholangiocarcinoma (Disease Ontology:DOID:4947); esophageal cancer (Disease Ontology:DOID:5041); pulmonary hypertension (Disease Ontology:DOID:6432); cocaine abuse (Disease Ontology:DOID:809); cataract (Disease Ontology:DOID:83); chronic ulcer of skin (Disease Ontology:DOID:8549); decubitus ulcer (Disease Ontology:DOID:8717); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); biliary tract disease (Disease Ontology:DOID:9741); diabetic neuropathy (Disease Ontology:DOID:9743); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (rno:54250); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190322); (R-RNO-190370); (R-RNO-190372); (R-RNO-190373); (R-RNO-190375); (R-RNO-190377); (R-RNO-3000170); (R-RNO-5654219); (R-RNO-5654221); (R-RNO-5654227); (R-RNO-5654228); (R-RNO-5654687); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5654720); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5658623); (R-RNO-5673001); (R-RNO-6811558); (R-RNO-9839397)", "pathway_count": 35, "publication_count": 10, "publication_id_list": "1378302;3196337;3387229;37224676;38468384;38493090;38811382;39288883;9048734;9065409", "class_list": "", "function": "Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity)., [UniProtKB, UniProtKB]; FGF2 activity regulates operant alcohol self-administration and mesolimbic dopamine transmission., [RefSeq, PubMed]; FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling., [RefSeq, PubMed]; Involvement of Fgf2-mediated tau protein phosphorylation in cognitive deficits induced by sevoflurane in aged rats. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown the moyamoya disease susceptibility gene, RNF213, upregulates the expression of basic fibroblast growth factor and matrix metalloproteinase-9 in bone marrow derived mesenchymal stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; LTBP2 down-regulated FGF2 to repress vascular smooth muscle cell proliferation and vascular remodeling in a rat model of intracranial aneurysm., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 42, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0046668 regulation of retinal cell programmed cell death;GO:0001759 organ induction;GO:1903672 positive regulation of sprouting angiogenesis;GO:0009792 embryo development ending in birth or egg hatching", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P13109-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14480-1", "uniprot_id": [ { "id": "FIBB_RAT", "url": "https://www.uniprot.org/uniprot/P14480", "type": "external" } ], "mass": 54235.0, "length": 479, "protein_name": "Fibrinogen beta chain", "gene_name": "Fgb", "organism": "Rat", "refseq_name": "fibrinogen beta chain precursor", "refseq_ac": [ { "id": "NP_064456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064456", "type": "external" } ], "gene_names_uniprotkb": "Fgb; Ab1-181; Ab1-216; Ac1-581", "gene_names_refseq": "Ab1-181; Ab1-216; Ac1-581; Fgb", "protein_names_uniprotkb": "Fibrinogen beta chain; Liver regeneration-related protein LRRG036/LRRG043/LRRG189", "protein_names_refseq": "beta-fibrinogen; fibrinogen beta chain precursor; fibrinogen, B beta polypeptide; fibrinogen, beta polypeptide; liver regeneration-related protein LRRG036/LRRG043/LRRG189", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); thrombosis (Disease Ontology:DOID:0060903); cardiovascular system disease (Disease Ontology:DOID:1287); congenital afibrinogenemia (Disease Ontology:DOID:2236); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (rno:24366); (R-RNO-114608); (R-RNO-216083); (R-RNO-354192); (R-RNO-354194); (R-RNO-372708); (R-RNO-5674135); (R-RNO-5686938); (R-RNO-9769733)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "21454685;2673932;34502162;3817019;6232608;7841303", "class_list": "", "function": "Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0P7;Q7TME5", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0051087 protein-folding chaperone binding;GO:0005198 structural molecule activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0045087 innate immune response;GO:0051592 response to calcium ion;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007160 cell-matrix adhesion;GO:0050714 positive regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P14480-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15129-1", "uniprot_id": [ { "id": "CP4B1_RAT", "url": "https://www.uniprot.org/uniprot/P15129", "type": "external" } ], "mass": 58936.0, "length": 511, "protein_name": "Cytochrome P450 4B1", "gene_name": "Cyp4b1", "organism": "Rat", "refseq_name": "cytochrome P450 4B1", "refseq_ac": [ { "id": "NP_058695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058695", "type": "external" } ], "gene_names_uniprotkb": "Cyp4b1; Cyp4b-1", "gene_names_refseq": "Cyp4b1", "protein_names_uniprotkb": "Cytochrome P450 4B1; 1.14.14.1; CYPIVB1; Cytochrome P450 L-2; Cytochrome P450 isozyme 5; P450 L-2", "protein_names_refseq": "CYPIVB1; P450 L-2; P450-isozyme 5; cytochrome P450 4B1; cytochrome P450 L-2; cytochrome P450 isozyme 5; cytochrome P450, subfamily 4B, polypeptide 1", "tax_id": 10116, "disease": "", "pathway": " (rno:24307); (R-RNO-211935); (R-RNO-211958); (R-RNO-211979); (R-RNO-2142691)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "16788951;2229008;2725471", "class_list": "", "function": "Catalyzes the omega- and (omega-1)-hydroxylation of saturated fatty acids and n-alkanes (PubMed:2229008). Also bioactivates xenobiotics such as the procarcinogen 3-methoxy-4-aminoazobenzene and the cyclic arylamines 2-aminofluorene and 2-aminoanthracene (By similarity). In addition, catalyzes O-dealkylation of 7-ethoxycoumarin (PubMed:2229008). Functions at the interface of xenobiotic and endobiotic metabolism, contributing both to fatty acid and hydrocarbon oxidation and to the bioactivation of diverse xenobiotics (PubMed:2229008). Preferentially hydroxylates the terminal carbon (omega-hydroxylation) of medium-chain fatty acids (C8-C10), with regioselectivity decreasing as chain length increases. C8 fatty acids and C7 n-alkanes display optimal chain length for regioselective omega-hydroxylation, and n-alkanes (C7-C10) are generally turned over faster and with higher regioselectivity than the corresponding fatty acids. In addition to omega/omega-1 hydroxylation, also catalyzes alpha-, beta-, gamma- and delta-hydroxylation of mid-chain length fatty acids, whereas fatty alcohols of the same chain length are almost exclusively hydroxylated at the omega, omega-1 and omega-2 positions (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Examination of high-power photomicrographs suggests that CYP4B1 may be a secreted protein, based on the fact that immunoreactivity appears to be present in the lumens of ducts of Bowman's glands and in secretory granules in respiratory mucosa., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.14.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.79", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497 monooxygenase activity;GO:1901363 heterocyclic compound binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0018879 biphenyl metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P15129-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15149-1", "uniprot_id": [ { "id": "CP2A2_RAT", "url": "https://www.uniprot.org/uniprot/P15149", "type": "external" } ], "mass": 56345.0, "length": 492, "protein_name": "Cytochrome P450 2A2", "gene_name": "Cyp2a2", "organism": "Rat", "refseq_name": "cytochrome P450 2A2", "refseq_ac": [ { "id": "NP_036825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036825", "type": "external" } ], "gene_names_uniprotkb": "Cyp2a2; Cyp2a-2", "gene_names_refseq": "CYP2A21; Cyp2a2; RATCYP2A21", "protein_names_uniprotkb": "Cytochrome P450 2A2; 1.14.14.1; CYPIIA2; Cytochrome P450-UT-4; Testosterone 15-alpha-hydroxylase", "protein_names_refseq": "CYPIIA2; Cytochrome P450 IIA2; P450-UT-4; cytochrome P450 2A2; cytochrome P450, subfamily 2A, polypeptide 1; cytochrome P450, subfamily 2A, polypeptide 2; cytochrome P450-UT-4; hepatic steroid hydroxylase IIA2 (CYP2A2); testosterone 15-alpha-hydroxylase", "tax_id": 10116, "disease": "intracranial aneurysm (Disease Ontology:DOID:10941); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:24895); (R-RNO-211935); (R-RNO-211981); (R-RNO-211999); (R-RNO-5423646)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "15539409;22217848;2322568;2434473;2650624;3192524", "class_list": "", "function": "Data suggest that structures of active sites of CYP2A1 and CYP2A2 have certain amount of flexibility and that non-specific binding (i.e., hydrophobic binding) is involved in differences in substrate specificity between these two enzymes., [RefSeq, PubMed]; Highly active in the 15-alpha-hydroxylation of testosterone., [UniProtKB]; Sex-dependent hepatocyte nuclear factors contribute to the sexually dimorphic expression of CYP2A2, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBB3", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity;GO:0008395 steroid hydroxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway;GO:0009804 coumarin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P15149-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16221-1", "uniprot_id": [ { "id": "COX8B_RAT", "url": "https://www.uniprot.org/uniprot/P16221", "type": "external" } ], "mass": 7549.0, "length": 70, "protein_name": "Cytochrome c oxidase subunit 8B, mitochondrial", "gene_name": "Cox8b", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 8B, mitochondrial precursor", "refseq_ac": [ { "id": "NP_036918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036918", "type": "external" } ], "gene_names_uniprotkb": "Cox8b; Cox8h", "gene_names_refseq": "CCO8A; COXVIII-H; Cox8b; Cox8h", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 8B, mitochondrial; Cytochrome c oxidase polypeptide VIII-heart; Cytochrome c oxidase subunit 8-1; Cytochrome c oxidase subunit 8H", "protein_names_refseq": "Cytochrom c oxidase subunit VIII-H (heart/muscle); Cytochrome c oxidase subunit VIII-H (heart/muscle); cytochrome c oxidase polypeptide VIII-heart; cytochrome c oxidase subunit 8-1; cytochrome c oxidase subunit 8B, mitochondrial precursor; cytochrome c oxidase subunit 8B, mitochondrial; cytochrome c oxidase subunit 8H; cytochrome c oxidase, subunit 8B; cytochrome c oxidase, subunit VIIIb, muscle", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25250)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1324738;2153407;7601105;8939982", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P16221-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16261-1", "uniprot_id": [ { "id": "GDC_RAT", "url": "https://www.uniprot.org/uniprot/P16261", "type": "external" } ], "mass": 36236.0, "length": 332, "protein_name": "Mitochondrial coenzyme A transporter SLC25A16", "gene_name": "Slc25a16", "organism": "Rat", "refseq_name": "mitochondrial coenzyme A transporter SLC25A16 isoform 1", "refseq_ac": [ { "id": "NP_001094330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094330", "type": "external" } ], "gene_names_uniprotkb": "Slc25a16", "gene_names_refseq": "Slc25a16", "protein_names_uniprotkb": "Mitochondrial coenzyme A transporter SLC25A16; Solute carrier family 25 member 16", "protein_names_refseq": "GDC; graves disease carrier protein; mitochondrial coenzyme A transporter SLC25A16 isoform 1; mitochondrial coenzyme A transporter SLC25A16; mitochondrial solute carrier protein homolog; solute carrier family 25 (mitochondrial carrier), member 16; solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16", "tax_id": 10116, "disease": "Graves' disease (Disease Ontology:DOID:12361)", "pathway": " (rno:361836); (R-RNO-199220)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2575220", "class_list": "", "function": "Mitochondrial inner membrane transporter that regulates coenzyme A homeostasis between cytosol and mitochondria. Could mediate the import of coenzyme A from the cytosol into the mitochondrial matrix. Alternatively, it could function in the export of 3'-dephospho-CoA from the mitochondrial matrix to the cytosol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A9K3Y7D2", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" } ], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015228 coenzyme A transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1990559 mitochondrial coenzyme A transmembrane transport;GO:0015880 coenzyme A transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P16261-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17777-1", "uniprot_id": [ { "id": "LIF_RAT", "url": "https://www.uniprot.org/uniprot/P17777", "type": "external" } ], "mass": 22113.0, "length": 202, "protein_name": "Leukemia inhibitory factor", "gene_name": "Lif", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lif", "gene_names_refseq": "", "protein_names_uniprotkb": "Leukemia inhibitory factor; Cholinergic neuronal differentiation factor; LIF", "protein_names_refseq": "", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); colon cancer (Disease Ontology:DOID:219); brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-6788467)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2512641;3143917", "class_list": "", "function": "Functions as a cytokine that binds to the LIF receptor complex. The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (By similarity). Functionally, regulates cell self-renewal, differentiation and survival of embryonic stem cells (ESCs) (PubMed:2512641, PubMed:3143917). Also is crucial for embryonic implantation (By similarity). Mechanistically, ligand binding to LIFR, induces heterodimerization with IL6ST/gp130 activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducers and activators of transcription (STAT3 and to lesser extent STAT1). In parallel to the activation of the STAT3-pathway, the binding of LIF to the LIF receptor complex leads to the activation of the mitogen-activated protein kinase (MAPK) and the phosphatidylinositol 3-kinase (PI(3)K) pathways. Tyrosine phosphorylation of the p85 subunit of PI(3)K by JAK1 leads to activation of the serine/ threonine kinase AKT (protein kinase B) (By similarity). PI(3)K-dependent signaling is required for efficient self-renewal of murine ES cells, and regulation of ERK activity is functionally important in this response (By similarity). Moreover, induces tyrosine phosphorylation of PTPN11, that associates with IL6ST/gp130-LIFR, which in turn recruits the p85 regulatory subunit of PI(3)K protein kinase, promoting PI3K-AKT activation, and GRB2-RAS-MAPK signaling (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes., [UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005146 leukemia inhibitory factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P17777-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18424-1", "uniprot_id": [ { "id": "LCAT_RAT", "url": "https://www.uniprot.org/uniprot/P18424", "type": "external" } ], "mass": 49882.0, "length": 440, "protein_name": "Phosphatidylcholine-sterol acyltransferase", "gene_name": "Lcat", "organism": "Rat", "refseq_name": "phosphatidylcholine-sterol acyltransferase precursor", "refseq_ac": [ { "id": "NP_058720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058720", "type": "external" } ], "gene_names_uniprotkb": "Lcat", "gene_names_refseq": "Lcat", "protein_names_uniprotkb": "Phosphatidylcholine-sterol acyltransferase; 1-alkyl-2-acetylglycerophosphocholine esterase; 2.3.1.43; 3.1.1.47; Lecithin-cholesterol acyltransferase; PAF acetylhydrolase; Phospholipid-cholesterol acyltransferase; Platelet-activating factor acetylhydrolase", "protein_names_refseq": "1-alkyl-2-acetylglycerophosphocholine esterase; Lecithin-cholesterol acyltransferase; PAF acetylhydrolase; phosphatidylcholine-sterol acyltransferase precursor; phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase; platelet-activating factor acetylhydrolase", "tax_id": 10116, "disease": "microcephaly, short stature, and limb abnormalities (Disease Ontology:DOID:0081431); microcephaly-micromelia syndrome (Disease Ontology:DOID:0081432); familial hyperlipidemia (Disease Ontology:DOID:1168); Norum disease (Disease Ontology:DOID:1391); syndrome (Disease Ontology:DOID:225); arteriosclerosis (Disease Ontology:DOID:2349); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:24530); (R-RNO-8964058)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14636062;2402469;8820107;9219904", "class_list": "", "function": "Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O35849", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0047179 platelet-activating factor acetyltransferase activity;GO:0004623 phospholipase A2 activity;GO:0034186 apolipoprotein A-I binding;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008203 cholesterol metabolic process;GO:0042157 lipoprotein metabolic process;GO:0042158 lipoprotein biosynthetic process;GO:0051384 response to glucocorticoid", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P18424-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18588-1", "uniprot_id": [ { "id": "MX1_RAT", "url": "https://www.uniprot.org/uniprot/P18588", "type": "external" } ], "mass": 74469.0, "length": 652, "protein_name": "Interferon-induced GTP-binding protein Mx1", "gene_name": "Mx1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mx1", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon-induced GTP-binding protein Mx1; Myxoma resistance protein 1; Myxovirus resistance protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease dominant intermediate B (Disease Ontology:DOID:0110197); centronuclear myopathy 1 (Disease Ontology:DOID:0111223); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); prostate cancer (Disease Ontology:DOID:10283); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); microcytic anemia (Disease Ontology:DOID:11252); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); hereditary spastic paraplegia (Disease Ontology:DOID:2476); liver disease (Disease Ontology:DOID:409); avian influenza (Disease Ontology:DOID:4492); myocardial infarction (Disease Ontology:DOID:5844); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (rno:24575)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18062906;2173790;29393594", "class_list": "", "function": "Interferon-induced dynamin-like GTPase which has antiviral activity against influenza A virus, (IAV) and Thogoto virus (THOV). Inhibits IAV by interfering with the process of primary transcription, probably by affecting the viral polymerase function (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P18588-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18590-1", "uniprot_id": [ { "id": "MX3_RAT", "url": "https://www.uniprot.org/uniprot/P18590", "type": "external" } ], "mass": 74952.0, "length": 659, "protein_name": "Interferon-induced GTP-binding protein Mx3", "gene_name": "Mx3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mx3", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon-induced GTP-binding protein Mx3; Myxovirus resistance protein 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2173790", "class_list": "", "function": "Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0071357 cellular response to type I interferon;GO:0046822 regulation of nucleocytoplasmic transport;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18590-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18645-1", "uniprot_id": [ { "id": "GALE_RAT", "url": "https://www.uniprot.org/uniprot/P18645", "type": "external" } ], "mass": 38225.0, "length": 347, "protein_name": "UDP-glucose 4-epimerase", "gene_name": "Gale", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gale", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucose 4-epimerase; 5.1.3.2; 5.1.3.7; Galactowaldenase; UDP-GalNAc 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-galactosamine 4-epimerase; UDP-galactose 4-epimerase", "protein_names_refseq": "", "tax_id": 10116, "disease": "galactose epimerase deficiency (Disease Ontology:DOID:0111458); thrombocytopenia (Disease Ontology:DOID:1588); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (rno:114860); (R-RNO-70370)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2205840", "class_list": "", "function": "Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.2", "type": "external" }, { "id": "5.1.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.7", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0003978 UDP-glucose 4-epimerase activity;GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0019388 galactose catabolic process;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18645-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19234-1", "uniprot_id": [ { "id": "NDUV2_RAT", "url": "https://www.uniprot.org/uniprot/P19234", "type": "external" } ], "mass": 27378.0, "length": 248, "protein_name": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial", "gene_name": "Ndufv2", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_112326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112326", "type": "external" } ], "gene_names_uniprotkb": "Ndufv2", "gene_names_refseq": "Ndufv2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; 7.1.1.2; NADH-ubiquinone oxidoreductase 24 kDa subunit", "protein_names_refseq": "24-kDa subunit of mitochondrial NADH dehydrogenase; NADH dehydrogenase (ubiquinone) flavoprotein 2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; NADH-ubiquinone oxidoreductase 24 kDa subunit", "tax_id": 10116, "disease": "nuclear type mitochondrial complex I deficiency 7 (Disease Ontology:DOID:0112092); Parkinson's disease (Disease Ontology:DOID:14330); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:81728); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "26446791;27213235;28219781;2974699;34502162", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains one iron-sulfur cluster., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NECA prevents mitochondrial oxidative stress by decreasing mitochondrial superoxide generation through inhibition of complex I via the mitochondrial Src tyrosine kinase. Phosphorylation of Tyr(118) residue in NDUFV2 subunit may account for the inhibitory effect of NECA on complex I., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDU9", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0007399 nervous system development;GO:0048738 cardiac muscle tissue development;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P19234-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19686-1", "uniprot_id": [ { "id": "GCYA1_RAT", "url": "https://www.uniprot.org/uniprot/P19686", "type": "external" } ], "mass": 77567.0, "length": 690, "protein_name": "Guanylate cyclase soluble subunit alpha-1", "gene_name": "Gucy1a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gucy1a1; Guc1a1; Gucy1a3", "gene_names_refseq": "", "protein_names_uniprotkb": "Guanylate cyclase soluble subunit alpha-1; 4.6.1.2; GCS-alpha-1; GCS-alpha-3; Guanylate cyclase soluble subunit alpha-3; Soluble guanylate cyclase large subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); primary open angle glaucoma (Disease Ontology:DOID:1070); Moyamoya disease (Disease Ontology:DOID:13099)", "pathway": " (R-RNO-445355)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1698769;8997507", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0020037 heme binding;GO:0070026 nitric oxide binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005654 nucleoplasm;GO:0008074 guanylate cyclase complex, soluble;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0008217 regulation of blood pressure;GO:0060087 relaxation of vascular associated smooth muscle;GO:0009635 response to herbicide;GO:0038060 nitric oxide-cGMP-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P19686-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20236-1", "uniprot_id": [ { "id": "GBRA3_RAT", "url": "https://www.uniprot.org/uniprot/P20236", "type": "external" } ], "mass": 55430.0, "length": 493, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-3", "gene_name": "Gabra3", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-3 precursor", "refseq_ac": [ { "id": "NP_058765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058765", "type": "external" } ], "gene_names_uniprotkb": "Gabra3; Gabra-3", "gene_names_refseq": "Gabra3", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-3; GABA(A) receptor subunit alpha-3; GABAAR subunit alpha-3", "protein_names_refseq": "GABA(A) receptor subunit alpha-3; GABA-A receptor alpha-3 subunit; GABAAR subunit alpha-3; Gamma-animobutyric acid (GABA) A receptor, alpha 3; gamma-aminobutyric acid (GABA) A receptor, alpha 3; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 3; gamma-aminobutyric acid receptor subunit alpha-3 precursor; gamma-aminobutyric acid receptor subunit alpha-3; gamma-aminobutyric acid type A receptor alpha3 subunit", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); multiple sclerosis (Disease Ontology:DOID:2377); bipolar disorder (Disease Ontology:DOID:3312); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:24947); (R-RNO-977443)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "17003036;1966765;2153588;22673903;24090084;26469128;33288547;38843836;39392023", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2153588). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Changes in D4 and GABAA subunit alpha3 receptors in the thalamic reticular nucleus caused by unilateral lesion of the globus pallidus. Publication Status: Online-Only, [RefSeq, PubMed]; GABAA Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain alpha3 and gamma1 Subunits and Present Differential Functional and Pharmacological Properties., [RefSeq, PubMed]; Sp4 functionally regulates the transcription of Gabra1 (GABAA alpha1) and Gabra2 (GABAA alpha2), but not Gabra3 (GABAA alpha3) subunit genes., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 6, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "F1LNZ5", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0045202 synapse;GO:0098794 postsynapse;GO:0034707 chloride channel complex", "go_biological_process": "GO:0031223 auditory behavior;GO:0010288 response to lead ion;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007268 chemical synaptic transmission;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P20236-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20411-1", "uniprot_id": [ { "id": "FCERG_RAT", "url": "https://www.uniprot.org/uniprot/P20411", "type": "external" } ], "mass": 9765.0, "length": 86, "protein_name": "High affinity immunoglobulin epsilon receptor subunit gamma", "gene_name": "Fcer1g", "organism": "Rat", "refseq_name": "high affinity immunoglobulin epsilon receptor subunit gamma precursor", "refseq_ac": [ { "id": "NP_001124473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124473", "type": "external" } ], "gene_names_uniprotkb": "Fcer1g; Fce1g", "gene_names_refseq": "Fcer1g", "protein_names_uniprotkb": "High affinity immunoglobulin epsilon receptor subunit gamma; Fc receptor gamma-chain; Fc-epsilon RI-gamma; FcRgamma; FceRI gamma; IgE Fc receptor subunit gamma", "protein_names_refseq": "Fc fragment of IgE receptor Ig; Fc fragment of IgE, high affinity I, receptor for; Fc receptor gamma-chain; Fc receptor, IgE, high affinity I, gamma polypeptide; fc-epsilon RI-gamma; fcRgamma; fceRI gamma; gamma polypeptide; high affinity immunoglobulin epsilon receptor subunit gamma precursor; high affinity immunoglobulin epsilon receptor subunit gamma; igE Fc receptor subunit gamma", "tax_id": 10116, "disease": "", "pathway": " (rno:25441); (R-RNO-114604); (R-RNO-2454202); (R-RNO-2730905); (R-RNO-2871796); (R-RNO-2871809); (R-RNO-2871837); (R-RNO-5621480); (R-RNO-6798695); (R-RNO-75892)", "pathway_count": 10, "publication_count": 8, "publication_id_list": "17728245;1825220;23921530;2521376;28033741;28393919;29393594;7623809", "class_list": "", "function": "Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation., [UniProtKB, UniProtKB]; Mast cells contribute to Mincle-mediated immunity through Syk activation triggered by association with the FcepsilonRIbetagamma complex. Publication Status: Online-Only, [RefSeq, PubMed]; The results presented in this paper suggest that the Mincle/MCL/FcepsilonRI-gamma complex is the functionally optimal form for these C-type lectin receptors on the surface of myeloid cells., [RefSeq, PubMed]; This study showed that CCL2, NF-kappaB1, RAC2, FCER1G and C1Q may contribute to the generation of neuropathic pain after sciatic nerve injury via immune and defense pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019767 IgE receptor activity;GO:0019863 IgE binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0032998 Fc-epsilon receptor I complex;GO:0033001 Fc-gamma receptor III complex", "go_biological_process": "GO:0002292 T cell differentiation involved in immune response;GO:0038094 Fc-gamma receptor signaling pathway;GO:0030316 osteoclast differentiation;GO:0002283 neutrophil activation involved in immune response;GO:0002431 Fc receptor mediated stimulatory signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P20411-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20595-1", "uniprot_id": [ { "id": "GCYB1_RAT", "url": "https://www.uniprot.org/uniprot/P20595", "type": "external" } ], "mass": 70456.0, "length": 619, "protein_name": "Guanylate cyclase soluble subunit beta-1", "gene_name": "Gucy1b1", "organism": "Rat", "refseq_name": "guanylate cyclase soluble subunit beta-1", "refseq_ac": [ { "id": "NP_036901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036901", "type": "external" } ], "gene_names_uniprotkb": "Gucy1b1; Guc1b3; Gucy1b3", "gene_names_refseq": "Gucy1b1; Gucy1b3; SGC", "protein_names_uniprotkb": "Guanylate cyclase soluble subunit beta-1; 4.6.1.2; GCS-beta-1; GCS-beta-3; Guanylate cyclase soluble subunit beta-3; Soluble guanylate cyclase small subunit", "protein_names_refseq": "GCS-beta-1; GCS-beta-3; guanylate cyclase 1 soluble subunit beta 3; guanylate cyclase 1, soluble, beta 3; guanylate cyclase soluble subunit beta-1; guanylate cyclase soluble subunit beta-3; guanylate cyclase, soluble, beta 1; soluble guanylate cyclase small subunit; soluble guanylyl cyclase beta 1 subunit", "tax_id": 10116, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:25202); (R-RNO-445355)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "20105301;2905128;30485489;35089807", "class_list": "", "function": "FoxO4 controls sGCbeta transcription in vascular smooth muscle., [RefSeq, PubMed]; GUCY1B3 was upregulated in neonatal rat ventricular myocytes in response to ischemia and reperfusion (IR) injury, and restored IR-induced cell death and apoptosis. Other results suggest that GUCY1B3 has an antiapoptotic effect and this effect is mediated by the activation of PKCepsilon and Akt., [RefSeq, PubMed]; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CH88", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0020037 heme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005829 cytosol;GO:0008074 guanylate cyclase complex, soluble;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0071732 cellular response to nitric oxide;GO:0038060 nitric oxide-cGMP-mediated signaling;GO:0070482 response to oxygen levels", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20595-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20695-1", "uniprot_id": [ { "id": "IFRD1_RAT", "url": "https://www.uniprot.org/uniprot/P20695", "type": "external" } ], "mass": 49783.0, "length": 449, "protein_name": "Interferon-related developmental regulator 1", "gene_name": "Ifrd1", "organism": "Rat", "refseq_name": "interferon-related developmental regulator 1", "refseq_ac": [ { "id": "NP_062115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062115", "type": "external" } ], "gene_names_uniprotkb": "Ifrd1; Pc4", "gene_names_refseq": "Ifrd1; Pc4", "protein_names_uniprotkb": "Interferon-related developmental regulator 1; IRPR; Nerve growth factor-inducible protein PC4", "protein_names_refseq": "IRPR; interferon-related developmental regulator 1; nerve growth factor-inducible protein PC4", "tax_id": 10116, "disease": "postaxial acrofacial dysostosis (Disease Ontology:DOID:0111259)", "pathway": " (rno:29596)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12691737;15743821;2467301;27358163;29393594;8028043", "class_list": "", "function": "Findings thus suggest that the stimulation of Errfi1 and Ifrd1 may be important for theca and granulosa cell differentiation and oocyte complexes expansion., [RefSeq, PubMed]; PC4 acts as a coactivator of MyoD and MEF2C by removing the inhibitory effect of HDAC4, thus exerting a pivotal function during myogenesis., [RefSeq, PubMed]; PC4 is a regulator of transcription involved in tissue regeneration after ischemic stroke., [RefSeq, PubMed]; Probably participates in neurogenesis. Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0014706 striated muscle tissue development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060612 adipose tissue development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P20695-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20909-1", "uniprot_id": [ { "id": "COBA1_RAT", "url": "https://www.uniprot.org/uniprot/P20909", "type": "external" } ], "mass": 181027.0, "length": 1804, "protein_name": "Collagen alpha-1(XI) chain", "gene_name": "Col11a1", "organism": "Rat", "refseq_name": "collagen alpha-1(XI) chain precursor", "refseq_ac": [ { "id": "NP_037249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037249", "type": "external" } ], "gene_names_uniprotkb": "Col11a1", "gene_names_refseq": "Col11a1", "protein_names_uniprotkb": "Collagen alpha-1(XI) chain", "protein_names_refseq": "collagen alpha-1(XI) chain precursor; collagen alpha-1(XI) chain; collagen type a1(XI)6A-7-8; collagen type a1(XI)6B-7; collagen, type XI, alpha 1; procollagen type XI alpha 1", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 37 (Disease Ontology:DOID:0070601); Stickler syndrome (Disease Ontology:DOID:0080046); fibrochondrogenesis 1 (Disease Ontology:DOID:0080672); Stickler syndrome 2 (Disease Ontology:DOID:0080675); autosomal recessive intellectual developmental disorder 18 (Disease Ontology:DOID:0081190); Marshall syndrome (Disease Ontology:DOID:0111510); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:25654); (R-RNO-1442490); (R-RNO-1650814); (R-RNO-2022090); (R-RNO-3000171); (R-RNO-8874081); (R-RNO-8948216)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "10753969;17062562;29577904;3182841;7721875", "class_list": "", "function": "Giantin plays a pivotal role in coordinated production of aggrecan, link protein and type XI collagen in chondrocytes., [RefSeq, PubMed]; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 3, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "F1LSI4;Q62750;Q63391;Q63392;Q63393;Q8VBY8;Q920Z7;Q920Z8;Q920Z9;Q921A0;Q921A1", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0046872 metal ion binding;GO:1904399 heparan sulfate binding;GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0005581 collagen trimer;GO:0005592 collagen type XI trimer;GO:0005585 collagen type II trimer", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0007601 visual perception;GO:0030199 collagen fibril organization;GO:0003007 heart morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P20909-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20942-1", "uniprot_id": [ { "id": "PHOS_RAT", "url": "https://www.uniprot.org/uniprot/P20942", "type": "external" } ], "mass": 28129.0, "length": 246, "protein_name": "Phosducin", "gene_name": "Pdc", "organism": "Rat", "refseq_name": "phosducin", "refseq_ac": [ { "id": "NP_037004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037004", "type": "external" } ], "gene_names_uniprotkb": "Pdc; Rpr1", "gene_names_refseq": "33DPTP; MEKA; Pdc; Rpr1", "protein_names_uniprotkb": "Phosducin; 33 kDa phototransducing protein; PHD; Protein MEKA; RPR-1; Rod photoreceptor 1", "protein_names_refseq": "33 kDa phototransducing protein; PHD; Phototransducing protein, 33 kDa (phosducin); RPR-1; phosducin; rod photoreceptor 1", "tax_id": 10116, "disease": "intermittent claudication (Disease Ontology:DOID:3669)", "pathway": " (rno:25343)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10360181;17569665;2071146;2210381;23199924;25971962;28402877", "class_list": "", "function": "14-3-3 phosphorylation of Pdc at Ser-54 and Ser-73 affects the structure of the whole Pdc molecule., [RefSeq, PubMed]; 14-3-3 protein-mediated inhibition of Pdc binding to Gtbetagamma is based on steric occlusion of Pdc's Gtbetagamma binding surface., [RefSeq, PubMed]; C-terminal domain of Pdc interacts with the outside surface of the 14-3-3 dimer., [RefSeq, PubMed]; Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism., [UniProtKB]; Phosducin has a role in regulating signaling in the rod outer segment compartment and there are distinct functions for phosphorylation sites 54 and 71, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63420", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007601 visual perception;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P20942-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21704-1", "uniprot_id": [ { "id": "DNAS1_RAT", "url": "https://www.uniprot.org/uniprot/P21704", "type": "external" } ], "mass": 32064.0, "length": 284, "protein_name": "Deoxyribonuclease-1", "gene_name": "Dnase1", "organism": "Rat", "refseq_name": "deoxyribonuclease-1 precursor", "refseq_ac": [ { "id": "NP_037229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037229", "type": "external" } ], "gene_names_uniprotkb": "Dnase1; Dnl1", "gene_names_refseq": "Dnase1", "protein_names_uniprotkb": "Deoxyribonuclease-1; 3.1.21.1; DNase I; Deoxyribonuclease I", "protein_names_refseq": "DNase I; alternatively spliced; deoxyribonuclease I; deoxyribonuclease-1 precursor", "tax_id": 10116, "disease": "primary sclerosing cholangitis (Disease Ontology:DOID:0060643); complex cortical dysplasia with other brain malformations 9 (Disease Ontology:DOID:0061138); primary biliary cholangitis (Disease Ontology:DOID:12236); autoimmune hepatitis (Disease Ontology:DOID:2048); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:25633)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12005024;12036587;15796714;2263485;33212932;8428592;9303433", "class_list": "", "function": "A comparison of the expression and transport of DNAse1 from rats and DNAse1L3 from mice is reported., [RefSeq, PubMed]; DNase I Induces Other Endonucleases in Kidney Tubular Epithelial Cells by Its DNA-Degrading Activity. Publication Status: Online-Only, [RefSeq, PubMed]; Results show that the chief cells of the stomach produce DNase I, [RefSeq, PubMed]; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:15796714, PubMed:8428592). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (PubMed:15796714). Among other functions, seems to be involved in cell death by apoptosis (PubMed:15796714, PubMed:8428592). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization. Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVU6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0004536 DNA nuclease activity;GO:0004530 deoxyribonuclease I activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0002283 neutrophil activation involved in immune response;GO:0070948 regulation of neutrophil mediated cytotoxicity;GO:0006915 apoptotic process;GO:0006308 DNA catabolic process;GO:0002673 regulation of acute inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P21704-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21744-1", "uniprot_id": [ { "id": "IBP4_RAT", "url": "https://www.uniprot.org/uniprot/P21744", "type": "external" } ], "mass": 27745.0, "length": 254, "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "Igfbp4", "organism": "Rat", "refseq_name": "insulin-like growth factor-binding protein 4 precursor", "refseq_ac": [ { "id": "NP_001004274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004274", "type": "external" } ], "gene_names_uniprotkb": "Igfbp4; Igfbp-4", "gene_names_refseq": "IBP4; IGF-BP4; Igfbp4", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4; IGFBP-4", "protein_names_refseq": "IBP-4; IGF-binding protein 4; IGFBP-4; insulin-like growth factor-binding protein 4 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:360622); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11182766;1704481;24175938;2480123;28595186;34906040;36868516;39244846;7679899", "class_list": "", "function": "IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors., [UniProtKB]; IGFBP-4 Proteolysis by PAPP-A in a Primary Culture of Rat Neonatal Cardiomyocytes under Normal and Hypertrophic Conditions., [RefSeq, PubMed]; IGFBP4 overexpression impaired BMP2-induced osteogenic differentiation potential of young MSCs, whereas IGFBP4 knockdown restored the osteogenic potency of aged MSCs. Moreover, IGFBP4 knockdown stimulated the activation of Erk and Smad by increasing phosphorylation., [RefSeq, PubMed]; Insulin-like growth factor binding protein 4 loaded electrospun membrane ameliorating tendon injury by promoting retention of IGF-1., [RefSeq, PubMed]; Specific cleavage of IGFBP-4 by papp-a in nervous tissue., [RefSeq, PubMed]; The temporal expression pattern of IGFBP-4 in the embryonic brain suggests an important role of IGFBP-4 in regulating differentiation of neural stem cells Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q68J74", "ec_number_list": [], "go_molecular_function": "GO:0005520 insulin-like growth factor binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0040008 regulation of growth;GO:0043410 positive regulation of MAPK cascade;GO:0010906 regulation of glucose metabolic process;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P21744-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21816-1", "uniprot_id": [ { "id": "CDO1_RAT", "url": "https://www.uniprot.org/uniprot/P21816", "type": "external" } ], "mass": 23026.0, "length": 200, "protein_name": "Cysteine dioxygenase type 1", "gene_name": "Cdo1", "organism": "Rat", "refseq_name": "cysteine dioxygenase type 1", "refseq_ac": [ { "id": "NP_434696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_434696", "type": "external" } ], "gene_names_uniprotkb": "Cdo1", "gene_names_refseq": "Cdo1", "protein_names_uniprotkb": "Cysteine dioxygenase type 1; 1.13.11.20; CDO-I; CDO; Cysteine dioxygenase type I", "protein_names_refseq": "CDO-I; CDO; cysteine dioxygenase 1, cytosolic; cysteine dioxygenase type 1; cysteine dioxygenase, type I; cytosolic cysteine dioxygenase 1", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:81718); (R-RNO-1614558)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "16611640;21839860;22122511;22673903;2334417;24084026;24929188;25390690;8973325;9824269", "class_list": "", "function": "A pH-dependent kinetic study shows that both cross-linked and un-cross-linked CDO are active but the optimal pH decreases with the presence of the cross-link., [RefSeq, PubMed]; Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Correlating crosslink formation with enzymatic activity in cysteine dioxygenase., [RefSeq, PubMed]; Data suggest that biocatalysis by cysteine dioxygenase (CDO1) involves formation of persulfides of both cysteine and 3-mercaptopropionic acid under reducing conditions; these persulfides are stabilized by iron in active site of CDO1., [RefSeq, PubMed]; Iron dissociation from the CDO active site exhibits an extremely slow dissociation rate constant, illustrating the stability of the resting state CDO; dioxygenase activity is directly proportional to the concentration of iron., [RefSeq, PubMed]; Rate-limiting enzyme of the cysteine catabolic process to taurine, which catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen., [UniProtKB, PubMed]; Redox switch commits CDO towards either formation of the Cys93-Tyr157 crosslink or oxidation of the cysteine substrate, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NS32", "ec_number_list": [ { "id": "1.13.11.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.20", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008198 ferrous iron binding;GO:0016151 nickel cation binding;GO:0017172 cysteine dioxygenase activity;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0045471 response to ethanol;GO:0051384 response to glucocorticoid;GO:0007595 lactation;GO:0051591 response to cAMP;GO:0043200 response to amino acid", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P21816-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22288-1", "uniprot_id": [ { "id": "GCH1_RAT", "url": "https://www.uniprot.org/uniprot/P22288", "type": "external" } ], "mass": 27057.0, "length": 241, "protein_name": "GTP cyclohydrolase 1", "gene_name": "Gch1", "organism": "Rat", "refseq_name": "GTP cyclohydrolase 1 precursor", "refseq_ac": [ { "id": "NP_077332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077332", "type": "external" } ], "gene_names_uniprotkb": "Gch1; Gch", "gene_names_refseq": "GTPCH-1; GTPCH; Gch1; Gch", "protein_names_uniprotkb": "GTP cyclohydrolase 1; 3.5.4.16; GTP cyclohydrolase I; GTP-CH-I", "protein_names_refseq": "GTP cyclohydrase I; GTP cyclohydrolase 1 precursor; GTP cyclohydrolase I; GTP-CH-I", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); dopa-responsive dystonia (Disease Ontology:DOID:0090043); BH4-deficient hyperphenylalaninemia B (Disease Ontology:DOID:0112225); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); transient cerebral ischemia (Disease Ontology:DOID:224); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); pulmonary fibrosis (Disease Ontology:DOID:3770); liver cirrhosis (Disease Ontology:DOID:5082); intestinal disease (Disease Ontology:DOID:5295); dystonia (Disease Ontology:DOID:543); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29244); (R-RNO-1474151)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11818540;17057711;19762783;1985963;22673903;2557335;28399119;36908807;7802677", "class_list": "", "function": "May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.16", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0032496 response to lipopolysaccharide;GO:0034612 response to tumor necrosis factor;GO:0008217 regulation of blood pressure;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P22288-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23265-1", "uniprot_id": [ { "id": "O1078_RAT", "url": "https://www.uniprot.org/uniprot/P23265", "type": "external" } ], "mass": 37541.0, "length": 333, "protein_name": "Olfactory receptor 1078", "gene_name": "Olr1078", "organism": "Rat", "refseq_name": "olfactory receptor 1078", "refseq_ac": [ { "id": "NP_997480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997480", "type": "external" } ], "gene_names_uniprotkb": "Olr1078", "gene_names_refseq": "Olr1078; Or7a37", "protein_names_uniprotkb": "Olfactory receptor 1078; Olfactory receptor-like protein F3", "protein_names_refseq": "olfactory receptor 1078; olfactory receptor-like protein F3", "tax_id": 10116, "disease": "", "pathway": " (rno:299593)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1840504", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23265-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23267-1", "uniprot_id": [ { "id": "OL287_RAT", "url": "https://www.uniprot.org/uniprot/P23267", "type": "external" } ], "mass": 34169.0, "length": 311, "protein_name": "Olfactory receptor 287", "gene_name": "Olr287", "organism": "Rat", "refseq_name": "olfactory receptor 287", "refseq_ac": [ { "id": "NP_775456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775456", "type": "external" } ], "gene_names_uniprotkb": "Olr287", "gene_names_refseq": "Olr287; Or6f2", "protein_names_uniprotkb": "Olfactory receptor 287; Olfactory receptor-like protein F6", "protein_names_refseq": "olfactory receptor 287; olfactory receptor-like protein F6", "tax_id": 10116, "disease": "", "pathway": " (rno:287001)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1840504", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23267-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23268-1", "uniprot_id": [ { "id": "O1082_RAT", "url": "https://www.uniprot.org/uniprot/P23268", "type": "external" } ], "mass": 35656.0, "length": 317, "protein_name": "Olfactory receptor 1082", "gene_name": "Olr1082", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Olr1082", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor 1082; Olfactory receptor-like protein F12", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287002)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1840504", "class_list": "", "function": "Odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23268-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23270-1", "uniprot_id": [ { "id": "OL226_RAT", "url": "https://www.uniprot.org/uniprot/P23270", "type": "external" } ], "mass": 36227.0, "length": 327, "protein_name": "Olfactory receptor 226", "gene_name": "Olr226", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Olr226", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor 226; Olfactory receptor-like protein I7", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:65140)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1840504", "class_list": "", "function": "Odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23270-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23271-1", "uniprot_id": [ { "id": "O1493_RAT", "url": "https://www.uniprot.org/uniprot/P23271", "type": "external" } ], "mass": 35316.0, "length": 312, "protein_name": "Olfactory receptor 1493", "gene_name": "Olr1493", "organism": "Rat", "refseq_name": "olfactory receptor 1493", "refseq_ac": [ { "id": "NP_001006610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006610", "type": "external" } ], "gene_names_uniprotkb": "Olr1493", "gene_names_refseq": "Olr1493", "protein_names_uniprotkb": "Olfactory receptor 1493; Olfactory receptor-like protein I8", "protein_names_refseq": "olfactory receptor 1493; olfactory receptor-like protein I8", "tax_id": 10116, "disease": "", "pathway": " (rno:363640)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1840504", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23271-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23272-1", "uniprot_id": [ { "id": "OLFI9_RAT", "url": "https://www.uniprot.org/uniprot/P23272", "type": "external" } ], "mass": 35455.0, "length": 314, "protein_name": "Olfactory receptor-like protein I9", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor-like protein I9", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1840504", "class_list": "", "function": "Odorant receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23272-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23274-1", "uniprot_id": [ { "id": "O1468_RAT", "url": "https://www.uniprot.org/uniprot/P23274", "type": "external" } ], "mass": 35474.0, "length": 314, "protein_name": "Olfactory receptor 1468", "gene_name": "Olr1468", "organism": "Rat", "refseq_name": "olfactory receptor 1468", "refseq_ac": [ { "id": "NP_001000724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000724", "type": "external" } ], "gene_names_uniprotkb": "Olr1468", "gene_names_refseq": "Olr1468; Or1e18", "protein_names_uniprotkb": "Olfactory receptor 1468; Olfactory receptor-like protein I15", "protein_names_refseq": "olfactory receptor 1468; olfactory receptor-like protein I15", "tax_id": 10116, "disease": "", "pathway": " (rno:404977)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1840504", "class_list": "", "function": "Odorant receptor., [UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "M0R8I5", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23274-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24393-1", "uniprot_id": [ { "id": "GRP_RAT", "url": "https://www.uniprot.org/uniprot/P24393", "type": "external" } ], "mass": 15702.0, "length": 147, "protein_name": "Gastrin-releasing peptide", "gene_name": "Grp", "organism": "Rat", "refseq_name": "gastrin-releasing peptide preproprotein", "refseq_ac": [ { "id": "NP_598254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598254", "type": "external" } ], "gene_names_uniprotkb": "Grp", "gene_names_refseq": "Grp", "protein_names_uniprotkb": "Gastrin-releasing peptide; GRP-10; GRP18-27; GRP", "protein_names_refseq": "gastrin-releasing peptide preproprotein", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); kidney failure (Disease Ontology:DOID:1074); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); pneumonia (Disease Ontology:DOID:552); congestive heart failure (Disease Ontology:DOID:6000); cerebrovascular disease (Disease Ontology:DOID:6713); chronic kidney disease (Disease Ontology:DOID:784); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:171101); (R-RNO-375276); (R-RNO-381771); (R-RNO-416476)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "17208656;26855425;2843761;33059246", "class_list": "", "function": "Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (By similarity). Contributes primarily to nonhistaminergic itch sensation (By similarity). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (By similarity). Contributes to the regulation of food intake (PubMed:17208656). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (PubMed:33059246). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V871", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0034774 secretory granule lumen;GO:0043005 neuron projection", "go_biological_process": "GO:0051970 negative regulation of transmission of nerve impulse;GO:0007218 neuropeptide signaling pathway;GO:0035176 social behavior;GO:0001503 ossification;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P24393-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24470-1", "uniprot_id": [ { "id": "CP2CN_RAT", "url": "https://www.uniprot.org/uniprot/P24470", "type": "external" } ], "mass": 56433.0, "length": 494, "protein_name": "Cytochrome P450 2C23", "gene_name": "Cyp2c23", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cyp2c23; Cyp2c-23", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 2C23; 1.14.14.-; Arachidonic acid epoxygenase; CYPIIC23", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:83790)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10491410;14742258;15766564;2263487;8246128;8514789", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonic acid (ARA, C20:4(n-6)) primarily to stereospecific products 8R,9S-, 11R,12S-, and 14S,15R-EET (PubMed:10491410, PubMed:14742258, PubMed:8246128). Plays a major role in the formation of EETs and hydroxy-EETs (HEETs) in kidney (PubMed:10491410, PubMed:14742258). Via EETs may inhibit the epithelial sodium channels (ENaCs) in nephron segments, preventing excessive sodium absorption during high dietary salt intake (By similarity). Participates in the formation of anti-inflammatory hydroxyepoxyeicosatrienoic acids (HEETs) by converting 20-hydroxyeicosatetraenoic acid (20-HETE) to 20,8,9-HEET, an activator of PPARA (PubMed:14742258). Metabolizes eicosapentaenoic acid (EPA, C20:5(n-3)) to epoxyeicosatetraenoic acid (EETeTr) regioisomers, 8,9-, 11,12-, 14,15-, and 17,18-EETeTr, preferentially producing 17R,18S enantiomer (PubMed:15766564). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8246128)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63914;Q64534", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" } ], "go_molecular_function": "GO:0008404 arachidonate 14,15-epoxygenase activity;GO:0008405 arachidonate 11,12-epoxygenase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046456 icosanoid biosynthetic process;GO:0042178 xenobiotic catabolic process;GO:0019369 arachidonate metabolic process;GO:0033574 response to testosterone;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P24470-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24473-1", "uniprot_id": [ { "id": "GSTK1_RAT", "url": "https://www.uniprot.org/uniprot/P24473", "type": "external" } ], "mass": 25493.0, "length": 226, "protein_name": "Glutathione S-transferase kappa 1", "gene_name": "Gstk1", "organism": "Rat", "refseq_name": "glutathione S-transferase kappa 1", "refseq_ac": [ { "id": "NP_852036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852036", "type": "external" } ], "gene_names_uniprotkb": "Gstk1", "gene_names_refseq": "DsbA-L; GST13-13; GSTkappa; Gstk1", "protein_names_uniprotkb": "Glutathione S-transferase kappa 1; 2.5.1.18; GST 13-13; GST class-kappa; GSTK1-1; Glutathione S-transferase subunit 13; rGSTK1", "protein_names_refseq": "GST 13-13; GST class-kappa; GSTK1-1; adiponectin multimerization protein; glutathione S-transferase kappa 1; glutathione S-transferase subunit 13; glutathione S-transferase, mitochondrial; rGSTK1", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); colon adenocarcinoma (Disease Ontology:DOID:234)", "pathway": " (rno:297029); (R-RNO-156590); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "14717589;1883325;8920976", "class_list": "", "function": "Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09034", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0005737 cytoplasm", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0001889 liver development;GO:0030855 epithelial cell differentiation;GO:0010042 response to manganese ion;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P24473-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26435-1", "uniprot_id": [ { "id": "NTCP_RAT", "url": "https://www.uniprot.org/uniprot/P26435", "type": "external" } ], "mass": 39295.0, "length": 362, "protein_name": "Hepatic sodium/bile acid cotransporter", "gene_name": "Slc10a1", "organism": "Rat", "refseq_name": "hepatic sodium/bile acid cotransporter", "refseq_ac": [ { "id": "NP_058743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058743", "type": "external" } ], "gene_names_uniprotkb": "Slc10a1; Ntcp", "gene_names_refseq": "Ntcp1; Ntcp; SBACT; Slc10a1", "protein_names_uniprotkb": "Hepatic sodium/bile acid cotransporter; NTCP; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; SLC10A1; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1", "protein_names_refseq": "NA-dependent cholate transporting protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; hepatic sodium/bile acid cotransporter; sodium-dependent bile acid cotransporter; sodium-dependent taurocholate cotransporting polypeptide; sodium/bile acid cotransporter; sodium/taurocholate cotransporting polypeptide; solute carrier family 10 (sodium/bile acid cotransporter family), member 1; solute carrier family 10 (sodium/bile acid cotransporter), member 1", "tax_id": 10116, "disease": "familial hypercholanemia 2 (Disease Ontology:DOID:0061182); developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); alcoholic hepatitis (Disease Ontology:DOID:12351); cholestasis (Disease Ontology:DOID:13580); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24777); (R-RNO-159418)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12034724;1961729;21454685;22673903;31088037;35580629;9486191", "class_list": "", "function": "As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:1961729). It is strictly dependent on the extracellular presence of sodium (PubMed:1961729). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:9486191). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; Structure of the bile acid transporter and HBV receptor NTCP., [RefSeq, PubMed]; The present study suggests that glycochenodeoxycholate triggers the retrieval of Ntcp from the basolateral membrane into the cytosol through an oxidative stress-dependent activation of Fyn., [RefSeq, PubMed]; Translocation requires activation of protein kinase B, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5BK99", "ec_number_list": [], "go_molecular_function": "GO:0015125 bile acid transmembrane transporter activity;GO:0008508 bile acid:sodium symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0045471 response to ethanol;GO:0015721 bile acid and bile salt transport;GO:0031667 response to nutrient levels;GO:0071466 cellular response to xenobiotic stimulus;GO:0043627 response to estrogen", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P26435-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26794-1", "uniprot_id": [ { "id": "PIM1_RAT", "url": "https://www.uniprot.org/uniprot/P26794", "type": "external" } ], "mass": 35631.0, "length": 313, "protein_name": "Serine/threonine-protein kinase pim-1", "gene_name": "Pim1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase pim-1", "refseq_ac": [ { "id": "NP_058730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058730", "type": "external" } ], "gene_names_uniprotkb": "Pim1; Pim-1", "gene_names_refseq": "Pim1", "protein_names_uniprotkb": "Serine/threonine-protein kinase pim-1; 2.7.11.1", "protein_names_refseq": "non-specific serine/threonine protein kinase; pim-1 oncogene; proto-oncogene serine/threonine-protein kinase Pim-1; proviral integration site 1; serine/threonine-protein kinase pim-1", "tax_id": 10116, "disease": "subcortical band heterotopia (Disease Ontology:DOID:0111169); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); epilepsy (Disease Ontology:DOID:1826); congenital nervous system abnormality (Disease Ontology:DOID:2490); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (rno:24649); (R-RNO-9968551)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10373478;12668877;15471855;16123140;1620615;29544221;30257237;30299595;31969012;32145290", "class_list": "", "function": "MiR-410-5p promotes the development of diabetic cardiomyopathy by suppressing PIM1-induced anti-apoptosis., [RefSeq, PubMed]; Overexpression of Pim1 in retinal ganglion cells is related to optic nerve repair following optic nerve crush., [RefSeq, PubMed]; PIM1 phosphorylates KU70 and initiates DNA repair signaling in pulmonary artery hypertension-pulmonary artery smooth muscle cells. PIM1 inhibitors represent a therapeutic option for patients with PAH., [RefSeq, PubMed]; Pim on PP2A activity may mediate the levels of c-Myc and the phosphorylation of proteins needed for increased protein synthesis, which could have a significant impact on tumor growth, [RefSeq, PubMed]; Pim-1 expression was observed in the neointima of balloon-injured rat carotid arteries and in human thoracic aortas and coronary arteries showing intimal thickening suggesting that Pim-1 plays a role in vascular smooth muscle proliferation, [RefSeq, PubMed]; Pim-1 is a novel kinase that phosphorylates cTnI primarily at Ser23/24 and Ser150 in cardiomyocytes, which in turn may modulate myofilament function under a variety of physiological and pathophysiological conditions., [RefSeq, PubMed]; Pim1 overexpression prevented NRVM apoptosis via upregulation of autophagy after hypoxia and oxidative stress, partly via activation of the AMPK/mTOR/ATG5 autophagy pathway., [RefSeq, PubMed]; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3) (By similarity). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1 (By similarity). Phosphorylation of MAP3K5, another proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B, induces 14-3-3 proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3 (By similarity). Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis (By similarity). Acts as a positive regulator of mTORC1 signaling by mediating phosphorylation and inhibition of DEPDC5 component of the GATOR1 complex. Acts as a negative regulator of innate immunity by mediating phosphorylation and inactivation of GBP1 in absence of infection: phosphorylation of GBP1 induces interaction with 14-3-3 protein sigma (SFN) and retention in the cytosol (By similarity). Also phosphorylates and activates the ATP-binding cassette transporter ABCG2, allowing resistance to drugs through their excretion from cells (By similarity). Promotes brown adipocyte differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The DE and NF-1 half-site mediate prolactin responsiveness of the pim-1 promoter, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0043024 ribosomal small subunit binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0070561 vitamin D receptor signaling pathway;GO:1905062 positive regulation of cardioblast proliferation;GO:0006468 protein phosphorylation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P26794-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26897-1", "uniprot_id": [ { "id": "IL2RA_RAT", "url": "https://www.uniprot.org/uniprot/P26897", "type": "external" } ], "mass": 30557.0, "length": 267, "protein_name": "Interleukin-2 receptor subunit alpha", "gene_name": "Il2ra", "organism": "Rat", "refseq_name": "interleukin-2 receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_037295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037295", "type": "external" } ], "gene_names_uniprotkb": "Il2ra", "gene_names_refseq": "IL2RAC; Il2ra", "protein_names_uniprotkb": "Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA", "protein_names_refseq": "IL-2 receptor alpha subunit; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; interleukin 2 receptor, alpha chain; interleukin-2 receptor subunit alpha precursor", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Korean hemorrhagic fever (Disease Ontology:DOID:0050200); inflammatory bowel disease (Disease Ontology:DOID:0050589); COVID-19 (Disease Ontology:DOID:0080600); type 1 diabetes mellitus 10 (Disease Ontology:DOID:0110749); ectodermal dysplasia 10A (Disease Ontology:DOID:0111663); ectodermal dysplasia 10B (Disease Ontology:DOID:0111665); immunodeficiency 41 (Disease Ontology:DOID:0111968); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); Sjogren's syndrome (Disease Ontology:DOID:12894); hypohidrotic ectodermal dysplasia (Disease Ontology:DOID:14793); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); lymphopenia (Disease Ontology:DOID:614); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:25704); (R-RNO-5673001); (R-RNO-9020558); (R-RNO-912526)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "1889461;29772575", "class_list": "", "function": "Adoptive transfusion of CD4+CD25+ (Interleukin-2 Receptor alpha) Regulatory T Cells into Experimental Autoimmune Neuritis model rats has significant therapeutic effects., [RefSeq, PubMed]; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004911 interleukin-2 receptor activity;GO:0019976 interleukin-2 binding", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0005893 interleukin-2 receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0002664 regulation of T cell tolerance induction;GO:0038110 interleukin-2-mediated signaling pathway;GO:0046013 regulation of T cell homeostatic proliferation;GO:0006954 inflammatory response;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P26897-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27274-1", "uniprot_id": [ { "id": "CD59_RAT", "url": "https://www.uniprot.org/uniprot/P27274", "type": "external" } ], "mass": 13790.0, "length": 126, "protein_name": "CD59 glycoprotein", "gene_name": "Cd59b; Cd59", "organism": "Rat", "refseq_name": "CD59 glycoprotein precursor", "refseq_ac": [ { "id": "NP_037057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037057", "type": "external" } ], "gene_names_uniprotkb": "Cd59b; Cd59; Cd59", "gene_names_refseq": "Cd59a; Cd59b; Cd59; MAC-IP; MACIF; MACIP", "protein_names_uniprotkb": "CD59 glycoprotein; MAC-IP; MAC-inhibitory protein; MACIF; Membrane attack complex inhibition factor; Protectin", "protein_names_refseq": "CD59 antigen; CD59 glycoprotein precursor; CD59 glycoprotein; CD59 molecule, complement regulatory protein; CD59b moleucle, complement regulatory protein; Cb59b molecule; MAC-inhibitory protein; membrane attack complex inhibition factor; protectin", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); colorectal carcinoma (Disease Ontology:DOID:0080199); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); endometrial cancer (Disease Ontology:DOID:1380); anterior uveitis (Disease Ontology:DOID:1407); ovarian cancer (Disease Ontology:DOID:2394); nephrosis (Disease Ontology:DOID:2527); glomerulonephritis (Disease Ontology:DOID:2921); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); myocardial infarction (Disease Ontology:DOID:5844); neuromyelitis optica (Disease Ontology:DOID:8869); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (rno:25407); (R-RNO-204005); (R-RNO-5694530); (R-RNO-6798695); (R-RNO-6807878)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "1376109;28212662;28750658;31412214;31989689;7528012", "class_list": "", "function": "Coenzyme Q10 attenuates rat hepatocarcinogenesis via the reduction of CD59 expression and phospholipase D activity., [RefSeq, PubMed]; Organ injury in neuromyelitis optica (NMO) seropositive CD59(-/-) rats was prevented by a complement inhibitor. Significant pathological changes in seropositive CD59(-/-) rats were not seen in optic nerve, spinal cord or brain, including circumventricular tissue. Results implicate a major protective role of CD59 outside of the central nervous system in seropositive NMO. Publication Status: Online-Only, [RefSeq, PubMed]; Potent inhibitor of the complement membrane attack complex (MAC) action, which protects self-cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study generated CD59(-/-) rats to investigate the role of CD59 in neuromyelitis optica spectrum disorders (NMO) and to create NMO pathology by passive transfer of AQP4-IgG. Results implicate an important role of CD59 in modulating NMO pathology in rats and demonstrate amplification of AQP4-IgG-induced NMO disease with CD59 knockout. Publication Status: Online-Only, [RefSeq, PubMed]; Study thus proposes the previously undescribed existence of non-GPI-anchored cytosolic CD59, which is required for insulin secretion., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001848 complement binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045087 innate immune response;GO:0042102 positive regulation of T cell proliferation;GO:0045916 negative regulation of complement activation;GO:0030449 regulation of complement activation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P27274-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28232-1", "uniprot_id": [ { "id": "CXB5_RAT", "url": "https://www.uniprot.org/uniprot/P28232", "type": "external" } ], "mass": 31047.0, "length": 271, "protein_name": "Gap junction beta-5 protein", "gene_name": "Gjb5", "organism": "Rat", "refseq_name": "gap junction beta-5 protein", "refseq_ac": [ { "id": "NP_062114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062114", "type": "external" } ], "gene_names_uniprotkb": "Gjb5; Cxn-31.1", "gene_names_refseq": "Cx31.1; Cxna; Gjb5", "protein_names_uniprotkb": "Gap junction beta-5 protein; Connexin-31.1; Cx31.1", "protein_names_refseq": "connexin a; connexin-31.1; gap junction beta-5 protein; gap junction membrane channel protein beta 5", "tax_id": 10116, "disease": "", "pathway": " (rno:29586); (R-RNO-190861)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "1370487", "class_list": "", "function": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0060708 spongiotrophoblast differentiation;GO:0060707 trophoblast giant cell differentiation;GO:0060713 labyrinthine layer morphogenesis;GO:1905867 epididymis development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P28232-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29456-1", "uniprot_id": [ { "id": "IL10_RAT", "url": "https://www.uniprot.org/uniprot/P29456", "type": "external" } ], "mass": 20426.0, "length": 178, "protein_name": "Interleukin-10", "gene_name": "Il10", "organism": "Rat", "refseq_name": "interleukin-10 precursor", "refseq_ac": [ { "id": "NP_036986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036986", "type": "external" } ], "gene_names_uniprotkb": "Il10; Il-10", "gene_names_refseq": "IL10X; If2a; Il10", "protein_names_uniprotkb": "Interleukin-10; CSIF; Cytokine synthesis inhibitory factor; IL-10", "protein_names_refseq": "CSIF; IL-10; cytokine synthesis inhibitory factor; interferon 2a; interleukin-10 precursor", "tax_id": 10116, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); ocular tuberculosis (Disease Ontology:DOID:0070344); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); COVID-19 (Disease Ontology:DOID:0080600); Graves ophthalmopathy (Disease Ontology:DOID:0081120); graft-versus-host disease (Disease Ontology:DOID:0081267); dry eye syndrome (Disease Ontology:DOID:10140); bacterial infectious disease (Disease Ontology:DOID:104); common cold (Disease Ontology:DOID:10459); stomach cancer (Disease Ontology:DOID:10534); celiac disease (Disease Ontology:DOID:10608); Alzheimer's disease (Disease Ontology:DOID:10652); open-angle glaucoma (Disease Ontology:DOID:1067); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); anogenital venereal wart (Disease Ontology:DOID:11168); allergic conjunctivitis (Disease Ontology:DOID:11204); disseminated intravascular coagulation (Disease Ontology:DOID:11247); trachoma (Disease Ontology:DOID:11265); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); gestational diabetes (Disease Ontology:DOID:11714); pericardial effusion (Disease Ontology:DOID:118); panuveitis (Disease Ontology:DOID:12030); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); factor VIII deficiency (Disease Ontology:DOID:12134); primary biliary cholangitis (Disease Ontology:DOID:12236); Graves' disease (Disease Ontology:DOID:12361); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); intermediate uveitis (Disease Ontology:DOID:12732); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); uveitis (Disease Ontology:DOID:13141); Behcet's disease (Disease Ontology:DOID:13241); Fanconi anemia (Disease Ontology:DOID:13636); endometrial cancer (Disease Ontology:DOID:1380); toxic shock syndrome (Disease Ontology:DOID:14115); choroid disease (Disease Ontology:DOID:1417); hypothyroidism (Disease Ontology:DOID:1459); prostatitis (Disease Ontology:DOID:14654); major depressive disorder (Disease Ontology:DOID:1470); aggressive periodontitis (Disease Ontology:DOID:1474); alcohol use disorder (Disease Ontology:DOID:1574); diffuse scleroderma (Disease Ontology:DOID:1580); thrombocytopenia (Disease Ontology:DOID:1588); mitral valve stenosis (Disease Ontology:DOID:1754); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); anemia (Disease Ontology:DOID:2355); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); glucosephosphate dehydrogenase deficiency (Disease Ontology:DOID:2862); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); severe acute respiratory syndrome (Disease Ontology:DOID:2945); high grade glioma (Disease Ontology:DOID:3070); central nervous system lymphoma (Disease Ontology:DOID:3234); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); liver cancer (Disease Ontology:DOID:3571); toxic encephalopathy (Disease Ontology:DOID:3602); skin disease (Disease Ontology:DOID:37); bronchus carcinoma (Disease Ontology:DOID:3904); cervical cancer (Disease Ontology:DOID:4362); allergic rhinitis (Disease Ontology:DOID:4481); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); gallbladder carcinoma (Disease Ontology:DOID:4948); esophageal cancer (Disease Ontology:DOID:5041); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); schizophrenia (Disease Ontology:DOID:5419); pneumonia (Disease Ontology:DOID:552); retinal disease (Disease Ontology:DOID:5679); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); liver carcinoma (Disease Ontology:DOID:686); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); thyrotoxicosis (Disease Ontology:DOID:7997); hyperthyroidism (Disease Ontology:DOID:7998); myocarditis (Disease Ontology:DOID:820); periodontitis (Disease Ontology:DOID:824); intestinal obstruction (Disease Ontology:DOID:8437); retinal artery occlusion (Disease Ontology:DOID:8483); lung disease (Disease Ontology:DOID:850); herpes zoster (Disease Ontology:DOID:8536); chronic myeloid leukemia (Disease Ontology:DOID:8552); lip cancer (Disease Ontology:DOID:8564); Hodgkin's lymphoma (Disease Ontology:DOID:8567); ulcerative colitis (Disease Ontology:DOID:8577); vasculitis (Disease Ontology:DOID:865); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); decubitus ulcer (Disease Ontology:DOID:8717); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); acute myeloid leukemia (Disease Ontology:DOID:9119); visceral leishmaniasis (Disease Ontology:DOID:9146); liver benign neoplasm (Disease Ontology:DOID:916); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408); steatotic liver disease (Disease Ontology:DOID:9452); postpartum depression (Disease Ontology:DOID:9478); pulmonary eosinophilia (Disease Ontology:DOID:9498); multiple myeloma (Disease Ontology:DOID:9538); aphthous stomatitis (Disease Ontology:DOID:9663); type 1 diabetes mellitus (Disease Ontology:DOID:9744); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25325); (R-RNO-6783783)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "1280414;36737628;37062956;38048666;38169599;38194074;8484757", "class_list": "", "function": "Ex Vivo Production of IL-1beta and IL-10 by Activated Blood Cells of Wistar Rats with Different Resistance to Hypoxia after Systemic Inflammatory Response Syndrome., [RefSeq, PubMed]; IL-10 dependent modulatory effect of regulatory B10 cells on local scar formation following Roux-en-Y choledochojejunostomy in a novel rat model., [RefSeq, PubMed]; Initial IL-10 production dominates the therapy of mesenchymal stem cell scaffold in spinal cord injury. Publication Status: Online-Only, [RefSeq, PubMed]; Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury. Publication Status: Online-Only, [RefSeq, PubMed]; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Reduced expression of Il10, Stat3, Hoxa10, and Itgb3 in the embryo implantation site of rat model with prenatal androgen-induced polycystic ovary syndrome., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 128, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63263", "ec_number_list": [], "go_molecular_function": "GO:0005141 interleukin-10 receptor binding;GO:0046983 protein dimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:1905571 interleukin-10 receptor complex", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus;GO:0034465 response to carbon monoxide;GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0060302 negative regulation of cytokine activity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P29456-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30348-1", "uniprot_id": [ { "id": "CXCL2_RAT", "url": "https://www.uniprot.org/uniprot/P30348", "type": "external" } ], "mass": 10783.0, "length": 100, "protein_name": "C-X-C motif chemokine 2", "gene_name": "Cxcl2", "organism": "Rat", "refseq_name": "C-X-C motif chemokine 2 precursor", "refseq_ac": [ { "id": "NP_446099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446099", "type": "external" } ], "gene_names_uniprotkb": "Cxcl2; Cinc3; Mip-2; Mip2; Scyb2", "gene_names_refseq": "Cxcl2; Mip-2; Scyb2", "protein_names_uniprotkb": "C-X-C motif chemokine 2; CINC-3; Cytokine-induced neutrophil chemoattractant 3; MIP2; Macrophage inflammatory protein 2", "protein_names_refseq": "C-X-C motif chemokine 2 precursor; C-X-C motif chemokine 2; CINC-3; MIP2; chemokine (C-X-C motif) ligand 2; cytokine-induced neutrophil chemoattractant 3; macrophage inflammatory protein 2; small inducible cytokine subfamily, member 2", "tax_id": 10116, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); alcohol-associated liver disease (Disease Ontology:DOID:0070658); Coronavirus infectious disease (Disease Ontology:DOID:0080599); COVID-19 (Disease Ontology:DOID:0080600); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); pleurisy (Disease Ontology:DOID:10247); viral pneumonia (Disease Ontology:DOID:10533); cystic fibrosis (Disease Ontology:DOID:1485); intrahepatic cholestasis (Disease Ontology:DOID:1852); brain edema (Disease Ontology:DOID:4724); pneumonia (Disease Ontology:DOID:552); periodontitis (Disease Ontology:DOID:824); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); cholangitis (Disease Ontology:DOID:9446)", "pathway": " (rno:114105); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "1415488;14624457;31422522;34850541;37121693;7665992;7883948;8043001;8471066;8607872", "class_list": "", "function": "Blocking CXC Motif Chemokine Ligand 2 Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Apoptosis and NLRP3 Inflammasome Activation., [RefSeq, PubMed]; CXCL2 inhibits axon outgrowth of dorsal root ganglia neurons., [RefSeq, PubMed]; Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation., [UniProtKB]; Rat peri-implant soft tissue specifically expressed CXCL2 on titanium implant during wound healing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5WA60", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010332 response to gamma radiation;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0001975 response to amphetamine", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P30348-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30713-1", "uniprot_id": [ { "id": "GSTT2_RAT", "url": "https://www.uniprot.org/uniprot/P30713", "type": "external" } ], "mass": 27439.0, "length": 244, "protein_name": "Glutathione S-transferase theta-2", "gene_name": "Gstt2", "organism": "Rat", "refseq_name": "glutathione S-transferase theta-2", "refseq_ac": [ { "id": "NP_036928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036928", "type": "external" } ], "gene_names_uniprotkb": "Gstt2", "gene_names_refseq": "Gstt2", "protein_names_uniprotkb": "Glutathione S-transferase theta-2; 2.5.1.18; GST 12-12; GST class-theta-2; Glutathione S-transferase 12; Glutathione S-transferase Yrs-Yrs", "protein_names_refseq": "GST 12-12; GST class-theta-2; glutathione S-transferase 12; glutathione S-transferase Yrs-Yrs; glutathione S-transferase theta-2-like; glutathione S-transferase theta-2", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (rno:29487); (R-RNO-156590)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1764080;1848757;2114406;34758158;7802657;8761485", "class_list": "", "function": "Catalyzes the inactivation of reactive sulfate esters in carcinogenic arylmethanols (PubMed:2114406). Highest activity towards ethacrynic acid and cumene hydroperoxide (PubMed:2114406)., [UniProtKB, PubMed]; Proanthocyanidins mitigate bile acid-induced changes in GSTT2 levels in a panel of racially diverse patient-derived primary esophageal cell cultures., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P36971", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009751 response to salicylic acid;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P30713-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31325-1", "uniprot_id": [ { "id": "PHKG2_RAT", "url": "https://www.uniprot.org/uniprot/P31325", "type": "external" } ], "mass": 46678.0, "length": 406, "protein_name": "Phosphorylase b kinase gamma catalytic chain, liver/testis isoform", "gene_name": "Phkg2", "organism": "Rat", "refseq_name": "phosphorylase b kinase gamma catalytic chain, liver/testis isoform", "refseq_ac": [ { "id": "NP_542151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542151", "type": "external" } ], "gene_names_uniprotkb": "Phkg2", "gene_names_refseq": "Phkg2", "protein_names_uniprotkb": "Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; 2.7.11.19; PHK-gamma-LT; PHK-gamma-T; Phosphorylase kinase subunit gamma-2", "protein_names_refseq": "PHK-gamma-LT; PHK-gamma-T; phosphorylase b kinase gamma catalytic chain, liver/testis isoform; phosphorylase kinase gamma subunit 2; phosphorylase kinase subunit gamma-2; phosphorylase kinase, gamma 2 (testis); serine/threonine-protein kinase PHKG2", "tax_id": 10116, "disease": "glycogen storage disease IXc (Disease Ontology:DOID:0111043); glycogen storage disease (Disease Ontology:DOID:2747); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:140671); (R-RNO-70221)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "1370475", "class_list": "", "function": "Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A5L8", "ec_number_list": [ { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" } ], "go_molecular_function": "GO:0004689 phosphorylase kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005964 phosphorylase kinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0005977 glycogen metabolic process;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P31325-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32215-1", "uniprot_id": [ { "id": "PACR_RAT", "url": "https://www.uniprot.org/uniprot/P32215", "type": "external" } ], "mass": 59637.0, "length": 523, "protein_name": "Pituitary adenylate cyclase-activating polypeptide type I receptor", "gene_name": "Adcyap1r1", "organism": "Rat", "refseq_name": "pituitary adenylate cyclase-activating polypeptide type I receptor isoform a precursor", "refseq_ac": [ { "id": "NP_001257508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257508", "type": "external" } ], "gene_names_uniprotkb": "Adcyap1r1", "gene_names_refseq": "Adcyap1r1; PAC1-R; PACAP-R1A; PACAP-R1; PACAPR1A; PACAPR1", "protein_names_uniprotkb": "Pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP type I receptor; PACAP-R-1; PACAP-R1", "protein_names_refseq": "ADCYAP receptor type 1; PACAP type I receptor; PACAP type IA receptor; PACAP-R-1A; adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; adenylate cyclase activating polypeptide 1 receptor 1; adenylate cyclase activating polypeptide 1 receptor type 1; adenylate cyclase activating polypeptide 1 type 1 receptor; pituitary adenylate cyclase activating polypeptide 1 receptor (1); pituitary adenylate cyclase activating polypeptide receptor; pituitary adenylate cyclase-activating polypeptide type I receptor isoform a precursor; pituitary adenylate cyclase-activating polypeptide type I receptor; pituitary adenylate cyclase-activating polypeptide type IA receptor", "tax_id": 10116, "disease": "cystitis (Disease Ontology:DOID:1679); post-traumatic stress disorder (Disease Ontology:DOID:2055)", "pathway": " (rno:24167)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "32186931;35001657;35460713;36430275;37511603;7687425;8392197;8394723;8394834;8396727", "class_list": "", "function": "Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus in the Rotenone model of Parkinson's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies. Publication Status: Online-Only, [RefSeq, PubMed]; Pituitary adenylate cyclase-activating polypeptide receptor activation in the hypothalamus recruits unique signaling pathways involved in energy homeostasis., [RefSeq, PubMed]; Pituitary adenylate cyclase-activating polypeptide type 1 receptor within the nucleus accumbens core mediates excessive alcohol drinking in alcohol-preferring rats., [RefSeq, PubMed]; We examined the direct effects of PACAP on dentate gyrus (DG) granule cells in brain slices using whole cell patch recordings in current clamp mode. PACAP significantly increased the intrinsic excitability of DG granule cells via PAC1 receptor activation., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q63414", "ec_number_list": [], "go_molecular_function": "GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity;GO:0008179 adenylate cyclase binding;GO:0017046 peptide hormone binding;GO:0031267 small GTPase binding;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0009986 cell surface", "go_biological_process": "GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0046058 cAMP metabolic process;GO:0006171 cAMP biosynthetic process;GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P32215-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33581-1", "uniprot_id": [ { "id": "GHR4_RAT", "url": "https://www.uniprot.org/uniprot/P33581", "type": "external" } ], "mass": 3466.0, "length": 32, "protein_name": "Growth hormone-related protein 4", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth hormone-related protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2351117", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P33581-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34131-1", "uniprot_id": [ { "id": "NTF4_RAT", "url": "https://www.uniprot.org/uniprot/P34131", "type": "external" } ], "mass": 22333.0, "length": 209, "protein_name": "Neurotrophin-4", "gene_name": "Ntf4", "organism": "Rat", "refseq_name": "neurotrophin-4 isoform X1", "refseq_ac": [ { "id": "XP_038958178", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038958178", "type": "external" } ], "gene_names_uniprotkb": "Ntf4; Nt4; Ntf5", "gene_names_refseq": "NT4P; Ntf4; Ntf5", "protein_names_uniprotkb": "Neurotrophin-4; NT-4; NT-5; Neurotrophin-5; Neutrophic factor 4", "protein_names_refseq": "neurotrophin-4 isoform X1", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25730); (R-RNO-1257604); (R-RNO-6811558); (R-RNO-9026527); (R-RNO-9028731)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "1313578;1742028", "class_list": "", "function": "Target-derived survival factor for peripheral sensory sympathetic neurons (By similarity). May promote ameloblast differentiation and subsequent reduction in proliferation of ameloblasts (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007402 ganglion mother cell fate determination;GO:0008052 sensory organ boundary specification;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008344 adult locomotory behavior;GO:0008544 epidermis development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P34131-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34901-1", "uniprot_id": [ { "id": "SDC4_RAT", "url": "https://www.uniprot.org/uniprot/P34901", "type": "external" } ], "mass": 21962.0, "length": 202, "protein_name": "Syndecan-4", "gene_name": "Sdc4", "organism": "Rat", "refseq_name": "syndecan-4 precursor", "refseq_ac": [ { "id": "NP_036781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036781", "type": "external" } ], "gene_names_uniprotkb": "Sdc4; Synd4", "gene_names_refseq": "RATRYUDOCA; RYUDOCA; Sdc4", "protein_names_uniprotkb": "Syndecan-4; Ryudocan core protein; SYND4", "protein_names_refseq": "Ryudocan/syndecan 4; SYND4; ryudocan core protein; syndecan-4 precursor", "tax_id": 10116, "disease": "bacterial infectious disease (Disease Ontology:DOID:104); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:24771); (R-RNO-1971475); (R-RNO-2022928); (R-RNO-2024096); (R-RNO-3000170); (R-RNO-975634); (R-RNO-9769739)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "11916978;1537865;26272378;27830760;32811537;38891079;7520439;8495865", "class_list": "", "function": "Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Exploring Syndecan-4 and MLP and Their Interaction in Primary Cardiomyocytes and H9c2 Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Syndecan-4 is involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc Publication Status: Online-Only, [RefSeq, PubMed]; Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells. Publication Status: Online-Only, [RefSeq, PubMed]; Syntenin-1 negatively regulates syndecan-4 function via oligomerization and/or syndecan-4 interaction, impacting cytoskeletal organization and cell migration. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 3, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0001968 fibronectin binding;GO:0070053 thrombospondin receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0043034 costamere", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0007155 cell adhesion;GO:0007267 cell-cell signaling;GO:0016477 cell migration;GO:0042130 negative regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P34901-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34987-1", "uniprot_id": [ { "id": "OL867_RAT", "url": "https://www.uniprot.org/uniprot/P34987", "type": "external" } ], "mass": 35225.0, "length": 312, "protein_name": "Olfactory receptor 867", "gene_name": "Olr867", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Olr867; Olr1172", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor 867; Gustatory receptor GUST27; Olfactory receptor 1172", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7685030", "class_list": "", "function": "Possible olfactory or taste receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P34987-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35171-1", "uniprot_id": [ { "id": "CX7A2_RAT", "url": "https://www.uniprot.org/uniprot/P35171", "type": "external" } ], "mass": 9353.0, "length": 83, "protein_name": "Cytochrome c oxidase subunit 7A2, mitochondrial", "gene_name": "Cox7a2-ps2; Cox7a2", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 7A2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_071948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071948", "type": "external" } ], "gene_names_uniprotkb": "Cox7a2-ps2; Cox7a2; Cox7a2; Cox7a3; Cox7al", "gene_names_refseq": "Cox7a2; Cox7a3", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7A2, mitochondrial; Cytochrome c oxidase subunit VIIa-L; Cytochrome c oxidase subunit VIIa-liver/heart", "protein_names_refseq": "cytochrome c oxidase polypeptide 7A2, mitochondrial; cytochrome c oxidase polypeptide VIIa-liver/heart; cytochrome c oxidase subunit 7A2, mitochondrial precursor; cytochrome c oxidase subunit 7A2, mitochondrial; cytochrome c oxidase subunit VIIa 3; cytochrome c oxidase subunit VIIa polypeptide 2; cytochrome c oxidase subunit VIIa-L; cytochrome c oxidase subunit VIIa-liver/heart; cytochrome c oxidase, subunit 7a 3; cytochrome c oxidase, subunit VIIa 2", "tax_id": 10116, "disease": "", "pathway": " (rno:29507); (rno:688386); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "2175025;2175887;26446791;7601105", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV;GO:0098803 respiratory chain complex", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P35171-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35407-1", "uniprot_id": [ { "id": "CXCR2_RAT", "url": "https://www.uniprot.org/uniprot/P35407", "type": "external" } ], "mass": 40532.0, "length": 359, "protein_name": "C-X-C chemokine receptor type 2", "gene_name": "Cxcr2", "organism": "Rat", "refseq_name": "C-X-C chemokine receptor type 2", "refseq_ac": [ { "id": "NP_058879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058879", "type": "external" } ], "gene_names_uniprotkb": "Cxcr2; Il8rb", "gene_names_refseq": "Cmkar2; Cxcr2; Il8rb", "protein_names_uniprotkb": "C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B", "protein_names_refseq": "C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; GRO/MGSA receptor; IL-8R B; chemokine (C-X-C motif) receptor 2; chemokine (C-X-C) receptor 2; high affinity interleukin-8 receptor B; interleukin 8 receptor, beta", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); WHIM syndrome 2 (Disease Ontology:DOID:0060973); nephritis (Disease Ontology:DOID:10952); urinary bladder cancer (Disease Ontology:DOID:11054); nephroblastoma (Disease Ontology:DOID:2154); IgA glomerulonephritis (Disease Ontology:DOID:2986); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); demyelinating disease (Disease Ontology:DOID:3213); acute pyelonephritis (Disease Ontology:DOID:559); end stage renal disease (Disease Ontology:DOID:783); periapical periodontitis (Disease Ontology:DOID:823); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:29385); (R-RNO-380108); (R-RNO-418594); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "32812337;36603746;38098294;8955112;9218548", "class_list": "", "function": "Inhibition of CXCR2 enhances CNS remyelination via modulating PDE10A/cAMP signaling pathway., [RefSeq, PubMed]; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Selective blocking of CXCR2 prevents and reverses atrial fibrillation in spontaneously hypertensive rats., [RefSeq, PubMed]; The Role and Mechanism of Spinal NF-kappaB-CXCL1/CXCR2 in Rats with Nucleus Pulposus-induced Radicular Pain., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004950 chemokine receptor activity;GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0042629 mast cell granule", "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P35407-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35896-1", "uniprot_id": [ { "id": "O1174_RAT", "url": "https://www.uniprot.org/uniprot/P35896", "type": "external" } ], "mass": 37654.0, "length": 331, "protein_name": "Olfactory receptor 1174", "gene_name": "Olr1174", "organism": "Rat", "refseq_name": "olfactory receptor 1174", "refseq_ac": [ { "id": "NP_001001016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001016", "type": "external" } ], "gene_names_uniprotkb": "Olr1174", "gene_names_refseq": "Olr1174; Or7d11c", "protein_names_uniprotkb": "Olfactory receptor 1174; Putative gustatory receptor PTE33", "protein_names_refseq": "olfactory receptor 1174; putative gustatory receptor PTE33", "tax_id": 10116, "disease": "", "pathway": " (rno:405390)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8380780", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Possible taste receptor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35896-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35897-1", "uniprot_id": [ { "id": "GU38_RAT", "url": "https://www.uniprot.org/uniprot/P35897", "type": "external" } ], "mass": 26376.0, "length": 234, "protein_name": "Putative gustatory receptor PTE38", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative gustatory receptor PTE38", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8380780", "class_list": "", "function": "Possible taste receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35897-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35898-1", "uniprot_id": [ { "id": "O1073_RAT", "url": "https://www.uniprot.org/uniprot/P35898", "type": "external" } ], "mass": 35013.0, "length": 311, "protein_name": "Olfactory receptor 1073", "gene_name": "Olr1073", "organism": "Rat", "refseq_name": "olfactory receptor 1073", "refseq_ac": [ { "id": "NP_001000998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000998", "type": "external" } ], "gene_names_uniprotkb": "Olr1073", "gene_names_refseq": "Olr1073; Or7a44", "protein_names_uniprotkb": "Olfactory receptor 1073; Putative gustatory receptor PTE45", "protein_names_refseq": "olfactory receptor 1073; putative gustatory receptor PTE45", "tax_id": 10116, "disease": "", "pathway": " (rno:405362)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29393594;8380780", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Possible taste receptor., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35898-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35899-1", "uniprot_id": [ { "id": "O1571_RAT", "url": "https://www.uniprot.org/uniprot/P35899", "type": "external" } ], "mass": 27711.0, "length": 249, "protein_name": "Olfactory receptor 1571", "gene_name": "Olr1571", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Olr1571", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor 1571; Putative gustatory receptor PTE58; Testis-expressed odorant receptor mT15r", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "11014824;8380780", "class_list": "", "function": "Possible taste receptor., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERW9", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35899-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36364-1", "uniprot_id": [ { "id": "FGF9_RAT", "url": "https://www.uniprot.org/uniprot/P36364", "type": "external" } ], "mass": 23414.0, "length": 208, "protein_name": "Fibroblast growth factor 9", "gene_name": "Fgf9", "organism": "Rat", "refseq_name": "fibroblast growth factor 9", "refseq_ac": [ { "id": "NP_037084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037084", "type": "external" } ], "gene_names_uniprotkb": "Fgf9; Fgf-9", "gene_names_refseq": "Fgf4b; Fgf9", "protein_names_uniprotkb": "Fibroblast growth factor 9; FGF-9; GAF; Glia-activating factor; HBGF-9", "protein_names_refseq": "FGF-9; GAF; HBGF-9; fibroblast growth factor 4b; fibroblast growth factor 9; glia-activating factor", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); multiple synostoses syndrome (Disease Ontology:DOID:0050794); warfarin resistance (Disease Ontology:DOID:0080665); multiple synostoses syndrome 3 (Disease Ontology:DOID:0081319); lung cancer (Disease Ontology:DOID:1324); kidney cancer (Disease Ontology:DOID:263); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pleuropulmonary blastoma (Disease Ontology:DOID:4769)", "pathway": " (rno:25444); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190322); (R-RNO-190371); (R-RNO-190372); (R-RNO-190373); (R-RNO-190375); (R-RNO-5654219); (R-RNO-5654221); (R-RNO-5654227); (R-RNO-5654228); (R-RNO-5654687); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5654720); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 31, "publication_count": 5, "publication_id_list": "31708099;33470768;35093630;37705188;8321227", "class_list": "", "function": "Expression of fibroblast growth factor 9 and its receptors in the dentate gyrus of hippocampus in poststroke depression rats., [RefSeq, PubMed]; FGF9 Is the Target of LncRNA FAF., [RefSeq, PubMed]; Fibroblast growth factor 9 (FGF9)-mediated neurodegeneration: Implications for progressive multiple sclerosis?, [RefSeq, PubMed]; MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells., [RefSeq, PubMed]; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005604 basement membrane", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P36364-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36365-1", "uniprot_id": [ { "id": "FMO1_RAT", "url": "https://www.uniprot.org/uniprot/P36365", "type": "external" } ], "mass": 59825.0, "length": 532, "protein_name": "Flavin-containing monooxygenase 1", "gene_name": "Fmo1", "organism": "Rat", "refseq_name": "flavin-containing monooxygenase 1", "refseq_ac": [ { "id": "NP_036924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036924", "type": "external" } ], "gene_names_uniprotkb": "Fmo1; Fmo-1", "gene_names_refseq": "Fmo1; RFMO1A", "protein_names_uniprotkb": "Flavin-containing monooxygenase 1; 1.14.13.148; 1.14.13.8; Dimethylaniline monooxygenase [N-oxide-forming] 1; Dimethylaniline oxidase 1; FMO 1; Hepatic flavin-containing monooxygenase 1; Trimethylamine monooxygenase", "protein_names_refseq": "FMO 1; dimethylaniline monooxygenase [N-oxide-forming] 1; dimethylaniline oxidase 1; flavin containing monooxygenase 1; flavin-containing monooxygenase 1; hepatic flavin-containing monooxygenase 1; trimethylamine monooxygenase", "tax_id": 10116, "disease": "chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411); renal hypertension (Disease Ontology:DOID:1073); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25256); (R-RNO-1614558); (R-RNO-217271)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11996886;15465034;19307449;24440618;8504165;9094723", "class_list": "", "function": "Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:8504165). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (By similarity). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (PubMed:8504165)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes., [RefSeq, PubMed]; FMO, whose dysfunction could be a reason for the apoptosis of dopaminergic neurons in rotenone model, might be a new clue of pathological proteins in rotenone model of parkinsonism, [RefSeq, PubMed]; Results suggest that nitric oxide acts directly in a cyclic GMP-independent mechanism by decreasing the half-life of flavin-containing monooxygenase 1 (FMO1) mRNA, thereby inducing impairment of FMO-related functions in endotoxemia, [RefSeq, PubMed]; The relationship between gender and development in the expression of FMO1 in the liver and kidney was determined, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7Q5", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.148", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.148", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.14.13.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.32", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0034899 trimethylamine monooxygenase activity;GO:0050661 NADP binding;GO:0004497 monooxygenase activity;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0046322 negative regulation of fatty acid oxidation;GO:0097009 energy homeostasis;GO:0006805 xenobiotic metabolic process;GO:0009404 toxin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P36365-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38656-1", "uniprot_id": [ { "id": "LA_RAT", "url": "https://www.uniprot.org/uniprot/P38656", "type": "external" } ], "mass": 47777.0, "length": 415, "protein_name": "Lupus La protein homolog", "gene_name": "Ssbl1; Ssb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ssbl1; Ssb; LOC680385; Ss-b; Ssbl1", "gene_names_refseq": "", "protein_names_uniprotkb": "Lupus La protein homolog; La autoantigen homolog; La ribonucleoprotein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:680385); (rno:81783)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;7916708", "class_list": "", "function": "Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000049 tRNA binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:1903608 protein localization to cytoplasmic stress granule;GO:0075522 IRES-dependent viral translational initiation;GO:0006409 tRNA export from nucleus;GO:0008033 tRNA processing;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P38656-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39878-1", "uniprot_id": [ { "id": "PA2GC_RAT", "url": "https://www.uniprot.org/uniprot/P39878", "type": "external" } ], "mass": 16919.0, "length": 150, "protein_name": "Group IIC secretory phospholipase A2", "gene_name": "Pla2g2c", "organism": "Rat", "refseq_name": "group IIC secretory phospholipase A2 precursor", "refseq_ac": [ { "id": "NP_062075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062075", "type": "external" } ], "gene_names_uniprotkb": "Pla2g2c", "gene_names_refseq": "Pla2g2c", "protein_names_uniprotkb": "Group IIC secretory phospholipase A2; 14 kDa phospholipase A2; 3.1.1.4; GIIC sPLA2; PLA2-8; Phosphatidylcholine 2-acylhydrolase 2C; sPLA2-IIC", "protein_names_refseq": "14 kDa phospholipase A2; GIIC sPLA2; PLA2-8; group IIC secretory phospholipase A2 precursor; group IIC secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 2C; phosphatidylcholine 2-acylhydrolase GIIC; phospholipase A2, group 2C; sPLA2-IIC", "tax_id": 10116, "disease": "", "pathway": " (rno:29387)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8083202", "class_list": "", "function": "PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0009395 phospholipid catabolic process;GO:0050482 arachidonate secretion;GO:0046470 phosphatidylcholine metabolic process;GO:0046471 phosphatidylglycerol metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P39878-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39951-1", "uniprot_id": [ { "id": "CDK1_RAT", "url": "https://www.uniprot.org/uniprot/P39951", "type": "external" } ], "mass": 34135.0, "length": 297, "protein_name": "Cyclin-dependent kinase 1", "gene_name": "Cdk1", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 1", "refseq_ac": [ { "id": "NP_062169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062169", "type": "external" } ], "gene_names_uniprotkb": "Cdk1; Cdc2a; Cdc2; Cdkn1", "gene_names_refseq": "Cdc2a; Cdc2; Cdk1", "protein_names_uniprotkb": "Cyclin-dependent kinase 1; 2.7.11.22; 2.7.11.23; CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase", "protein_names_refseq": "Cell division cycle control protein 2; cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle 2, G1 to S and G2 to M; cell division protein kinase 1; cyclin-dependent kinase 1; p34 protein kinase", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); transitional cell carcinoma (Disease Ontology:DOID:2671); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); cervical cancer (Disease Ontology:DOID:4362); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:54237); (R-RNO-110056); (R-RNO-174048); (R-RNO-174184); (R-RNO-176408); (R-RNO-176412); (R-RNO-176417); (R-RNO-2299718); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-2980767); (R-RNO-2995383); (R-RNO-3301854); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-4419969); (R-RNO-5620912); (R-RNO-5687128); (R-RNO-5689896); (R-RNO-6804114); (R-RNO-6804757); (R-RNO-68875); (R-RNO-69273); (R-RNO-69478); (R-RNO-75035); (R-RNO-8852276); (R-RNO-8854518); (R-RNO-9833482)", "pathway_count": 30, "publication_count": 18, "publication_id_list": "10542199;17200138;19821535;25092827;25126482;25148827;2541912;25604742;26896066;26898445;26982431;26991553;27701050;28763745;28836261;32841050;34839004;36125973", "class_list": "", "function": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and ''cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats., [RefSeq, PubMed]; Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo., [RefSeq, PubMed]; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (PubMed:10542199, PubMed:19821535). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, ASB7, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, UHRF1, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS, GLI2, ZAR1 and RUNX2 (PubMed:10542199, PubMed:19821535). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (By similarity). Essential for early stages of embryonic development (By similarity). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (By similarity). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (By similarity). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (By similarity). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (By similarity). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (By similarity). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (By similarity). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (By similarity). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (By similarity). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (By similarity). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (By similarity). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (By similarity). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (By similarity). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (By similarity). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (PubMed:17200138). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (By similarity). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (By similarity). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (By similarity). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (By similarity). Phosphorylates SKA3 during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BJB4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005813 centrosome", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0044772 mitotic cell cycle phase transition;GO:1902850 microtubule cytoskeleton organization involved in mitosis;GO:0006468 protein phosphorylation;GO:0007077 mitotic nuclear membrane disassembly", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P39951-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41237-1", "uniprot_id": [ { "id": "CTXN1_RAT", "url": "https://www.uniprot.org/uniprot/P41237", "type": "external" } ], "mass": 9069.0, "length": 82, "protein_name": "Cortexin-1", "gene_name": "Ctxn1", "organism": "Rat", "refseq_name": "cortexin-1", "refseq_ac": [ { "id": "NP_001103405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103405", "type": "external" } ], "gene_names_uniprotkb": "Ctxn1; Ctxn", "gene_names_refseq": "Ctxn1; Ctxn", "protein_names_uniprotkb": "Cortexin-1", "protein_names_refseq": "C-terminal binding protein 1; cortexin-1", "tax_id": 10116, "disease": "", "pathway": " (rno:29145)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8336151", "class_list": "", "function": "May mediate extracellular or intracellular signaling of cortical neurons during forebrain development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P41237-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46418-1", "uniprot_id": [ { "id": "GSTA5_RAT", "url": "https://www.uniprot.org/uniprot/P46418", "type": "external" } ], "mass": 25347.0, "length": 221, "protein_name": "Glutathione S-transferase alpha-5", "gene_name": "Gsta5", "organism": "Rat", "refseq_name": "glutathione S-transferase alpha-5 isoform 1", "refseq_ac": [ { "id": "NP_001009920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009920", "type": "external" } ], "gene_names_uniprotkb": "Gsta5; Gstyc2", "gene_names_refseq": "Gsta3; Gsta5; Yc2", "protein_names_uniprotkb": "Glutathione S-transferase alpha-5; 2.5.1.18; GST A5-5; GST Yc2; Glutathione S-transferase Yc-2", "protein_names_refseq": "GST A5-5; GST Yc2; glutathione S-transferase A3; glutathione S-transferase Yc2 subunit; glutathione S-transferase alpha-5 isoform 1; glutathione S-transferase alpha-5", "tax_id": 10116, "disease": "", "pathway": " (rno:494500); (R-RNO-156590); (R-RNO-189483); (R-RNO-9748787)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "1953636;27602565;31443720;31617428;8051171;8761455", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has substantial activity toward aflatoxin B1-8,9-epoxide., [UniProtKB]; GSTA3 inhibited hepatic stellate cell activation and liver fibrosis Erratum:[J Transl Med. 2020 Apr 30;18(1):182. doi: 10.1186/s12967-020-02346-4. PMID: 32354374] Publication Status: Online-Only, [RefSeq, PubMed]; Protein and mRNA expression of GSTA3 in UUO rats and NRK-52E cells were determined by Western blot and RT-PCR. siRNA and overexpression plasmid were transfected specifically to assess the role of GSTA3 in renal interstitial fibrosis Publication Status: Online-Only, [RefSeq, PubMed]; The PI3K-KEAP1/Nrf2-GSTA3 signaling pathway is a possible mechanism of resisting external stimulation of renal fibrosis factors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6LD91", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P46418-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47742-1", "uniprot_id": [ { "id": "GBRR2_RAT", "url": "https://www.uniprot.org/uniprot/P47742", "type": "external" } ], "mass": 54296.0, "length": 465, "protein_name": "Gamma-aminobutyric acid receptor subunit rho-2", "gene_name": "Gabrr2", "organism": "Rat", "refseq_name": "gamma-aminobutyric acid receptor subunit rho-2 precursor", "refseq_ac": [ { "id": "NP_058988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058988", "type": "external" } ], "gene_names_uniprotkb": "Gabrr2", "gene_names_refseq": "Gabrr2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit rho-2; GABA(A) receptor subunit rho-2; GABA(C) receptor; GABAAR subunit rho-2", "protein_names_refseq": "GABA(A) receptor subunit rho-2; GABA(C) receptor; GABAAR subunit rho-2; gamma-aminobutyric acid (GABA) A receptor, rho 2; gamma-aminobutyric acid (GABA) receptor, rho 2; gamma-aminobutyric acid (GABA-A) receptor, subunit rho 2; gamma-aminobutyric acid (GABA-C) receptor, subunit rho 2; gamma-aminobutyric acid A receptor, rho 2; gamma-aminobutyric acid receptor subunit rho-2 precursor; gamma-aminobutyric acid receptor subunit rho-2; gamma-aminobutyric acid type A receptor rho 2 subunit", "tax_id": 10116, "disease": "autistic disorder (Disease Ontology:DOID:12849); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:29695); (R-RNO-977443)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11891787;12431995;12706246;15617751;18201822;7643126;8524843", "class_list": "", "function": "GABA(C) receptors are specifically involved in aspects of visual image motion processing in the rat brain., [RefSeq, PubMed]; Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:8524843). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:8524843). Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission (By similarity). Rho-2 GABAARs are also involved in neuronal tonic (extrasynaptic) and phasic (synaptic) transmission in the Purkinje neurons of the cerebellum (By similarity). Rho-2 GABAARs expressed in retina may play a role in retinal neurotransmission (PubMed:7643126)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]; The expression of GABA(C) receptors in the cerebellum adds a new dimension to the regulation of GABAergic neurotransmission, [RefSeq, PubMed]; The proportion of neurons in the brainstem with immunoreactivity for the GABA(B)R2 subunit included catecholamine and serotonin neurons., [RefSeq, PubMed]; The rho1 and rho2 products appeared to be developmentally regulated; they were found to be more pronounced in adulthood., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005237 inhibitory extracellular ligand-gated monoatomic ion channel activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0097708 intracellular vesicle;GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0007601 visual perception;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47742-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48721-1", "uniprot_id": [ { "id": "HSPA9_RAT", "url": "https://www.uniprot.org/uniprot/P48721", "type": "external" } ], "mass": 73745.0, "length": 679, "protein_name": "Stress-70 protein, mitochondrial", "gene_name": "Hspa9", "organism": "Rat", "refseq_name": "stress-70 protein, mitochondrial", "refseq_ac": [ { "id": "NP_001094128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094128", "type": "external" } ], "gene_names_uniprotkb": "Hspa9; Grp75; Hspa9a", "gene_names_refseq": "Crp40; GRP-75; Hspa9a; Hspa9; PBP74", "protein_names_uniprotkb": "Stress-70 protein, mitochondrial; 3.6.4.10; 75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9; Mortalin; PBP74; Peptide-binding protein 74; mtHSP70", "protein_names_refseq": "75 kDa glucose-regulated protein; GRP 75; catecholamine regulated protein 40; heat shock 70 kDa protein 9; heat shock 70kDa protein 9A; heat shock protein 9; heat shock protein family A member 9; heat shock protein, A; mortalin; mtHSP70; peptide-binding protein 74; stress-70 protein, mitochondrial-like; stress-70 protein, mitochondrial", "tax_id": 10116, "disease": "autosomal dominant sideroblastic anemia 4 (Disease Ontology:DOID:0060335); Parkinsonism (Disease Ontology:DOID:0080855); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); brain ischemia (Disease Ontology:DOID:2316); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:291671); (R-RNO-3371453); (R-RNO-6799198); (R-RNO-9837999); (R-RNO-9865881)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "17178908;2372296;28098881;34489498;38527700;38843836;7629893;7811387", "class_list": "", "function": "GRP75 expression is significantly decreased in brain tissues following ICH, and that overexpression of GRP75 inhibits inflammation and neuronal apoptosis in a rat model of ICH., [RefSeq, PubMed]; HSPA9/Mortalin mediates axo-protection and modulates mitochondrial dynamics in neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones. In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (By similarity). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Potential targets for the treatment of MI: GRP75-mediated Ca[2+] transfer in MAM., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1M953", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "2.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.7", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0097068 response to thyroxine;GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:0030218 erythrocyte differentiation;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P48721-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49651-1", "uniprot_id": [ { "id": "P2RY1_RAT", "url": "https://www.uniprot.org/uniprot/P49651", "type": "external" } ], "mass": 42322.0, "length": 373, "protein_name": "P2Y purinoceptor 1", "gene_name": "P2ry1", "organism": "Rat", "refseq_name": "P2Y purinoceptor 1", "refseq_ac": [ { "id": "NP_036932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036932", "type": "external" } ], "gene_names_uniprotkb": "P2ry1", "gene_names_refseq": "P2ry1; P2y1; P2y", "protein_names_uniprotkb": "P2Y purinoceptor 1; ATP receptor; P2Y1; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2 purinoreceptor subclass 2Y; P2Y ATP receptor 1; P2Y purinoceptor 1; purinergic receptor P2Y, G-protein coupled, 1", "tax_id": 10116, "disease": "impotence (Disease Ontology:DOID:1875); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25265); (R-RNO-416476); (R-RNO-417957); (R-RNO-418592)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "31689490;33848220;34166321;35907034;38043889;7779087", "class_list": "", "function": "A Role for The P2Y1 Receptor in Nonsynaptic Cross-depolarization in the Rat Dorsal Root Ganglia., [RefSeq, PubMed]; Abeta1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes. Publication Status: Online-Only, [RefSeq, PubMed]; P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold Hyperalgesia via Transient Receptor Potential Melastatin 8-Dependent Regulation of N-methyl-d-aspartate Receptor Phosphorylation in Dorsal Root Ganglion., [RefSeq, PubMed]; P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy., [RefSeq, PubMed]; Receptor for extracellular adenine nucleotides such as ADP (PubMed:7779087). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Transcutaneous auricular vagal nerve stimulation inhibits hypothalamic P2Y1R expression and attenuates weight gain without decreasing food intake in Zucker diabetic fatty rats., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001621 G protein-coupled ADP receptor activity;GO:0031686 A1 adenosine receptor binding;GO:0045031 G protein-coupled ATP receptor activity;GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0014069 postsynaptic density", "go_biological_process": "GO:0090075 relaxation of muscle;GO:0060406 positive regulation of penile erection;GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P49651-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49950-1", "uniprot_id": [ { "id": "BCL2_RAT", "url": "https://www.uniprot.org/uniprot/P49950", "type": "external" } ], "mass": 26622.0, "length": 236, "protein_name": "Apoptosis regulator Bcl-2", "gene_name": "Bcl2", "organism": "Rat", "refseq_name": "apoptosis regulator Bcl-2", "refseq_ac": [ { "id": "NP_058689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058689", "type": "external" } ], "gene_names_uniprotkb": "Bcl2; Bcl-2", "gene_names_refseq": "Bcl-2; Bcl2", "protein_names_uniprotkb": "Apoptosis regulator Bcl-2", "protein_names_refseq": "B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl-2alpha; Bcl2-like protein; apoptosis regulator Bcl-2", "tax_id": 10116, "disease": "", "pathway": " (rno:24224)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "19228691;19879923;25744447;29129468;30980393;37813166;38344831;38396011;7828536;7969891;8144041", "class_list": "", "function": "Ameliorating diabetes-induced testicular dysfunction by modulating PKC/Nrf2/Bcl-2 signaling: Protective role of sulbutiamine., [RefSeq, PubMed]; Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Potential role of Bcl2 in lipid metabolism and synaptic dysfunction of age-related hearing loss., [RefSeq, PubMed]; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62837;Q64032", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0002260 lymphocyte homeostasis;GO:0002360 T cell lineage commitment;GO:0002931 response to ischemia;GO:0006979 response to oxidative stress;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P49950-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50398-1", "uniprot_id": [ { "id": "GDIA_RAT", "url": "https://www.uniprot.org/uniprot/P50398", "type": "external" } ], "mass": 50537.0, "length": 447, "protein_name": "Rab GDP dissociation inhibitor alpha", "gene_name": "Gdi1", "organism": "Rat", "refseq_name": "rab GDP dissociation inhibitor alpha", "refseq_ac": [ { "id": "NP_058784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058784", "type": "external" } ], "gene_names_uniprotkb": "Gdi1; Rabgdia", "gene_names_refseq": "Gdi1", "protein_names_uniprotkb": "Rab GDP dissociation inhibitor alpha; GDI-1; Guanosine diphosphate dissociation inhibitor 1; Rab GDI alpha", "protein_names_refseq": "GDI-1; guanosine diphosphate dissociation inhibitor 1; rab GDI alpha; rab GDP dissociation inhibitor alpha", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 41 (Disease Ontology:DOID:0112058); cancer (Disease Ontology:DOID:162); psychotic disorder (Disease Ontology:DOID:2468)", "pathway": " (rno:25183); (R-RNO-8876198)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10996854;18683930;7513052;8188702", "class_list": "", "function": "Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP., [UniProtKB, UniProtKB]; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499U0;Q9R274", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0005093 Rab GDP-dissociation inhibitor activity;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0034123 positive regulation of toll-like receptor signaling pathway;GO:0015031 protein transport;GO:0051592 response to calcium ion;GO:0016192 vesicle-mediated transport;GO:0045773 positive regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P50398-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51145-1", "uniprot_id": [ { "id": "FOSL2_RAT", "url": "https://www.uniprot.org/uniprot/P51145", "type": "external" } ], "mass": 35255.0, "length": 326, "protein_name": "Fos-related antigen 2", "gene_name": "Fosl2", "organism": "Rat", "refseq_name": "fos-related antigen 2 isoform 1", "refseq_ac": [ { "id": "NP_037086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037086", "type": "external" } ], "gene_names_uniprotkb": "Fosl2; Fra-2; Fra2", "gene_names_refseq": "Fosl2; Fra2", "protein_names_uniprotkb": "Fos-related antigen 2; FRA-2", "protein_names_refseq": "FOS like 2, AP-1 trancription factor subunit; FRA-2; fos-like antigen 2; fos-related antigen 2 isoform 1; fos-related antigen 2", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); colon adenocarcinoma (Disease Ontology:DOID:234); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); renal carcinoma (Disease Ontology:DOID:4451); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:25446)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15299028;19103603;22673903;7592994", "class_list": "", "function": "Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (PubMed:15299028)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6GXE4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0035976 transcription factor AP-1 complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0030223 neutrophil differentiation;GO:1901142 insulin metabolic process;GO:0061144 alveolar secondary septum development;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P51145-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51577-1", "uniprot_id": [ { "id": "P2RX4_RAT", "url": "https://www.uniprot.org/uniprot/P51577", "type": "external" } ], "mass": 43501.0, "length": 388, "protein_name": "P2X purinoceptor 4", "gene_name": "P2rx4", "organism": "Rat", "refseq_name": "P2X purinoceptor 4", "refseq_ac": [ { "id": "NP_113782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113782", "type": "external" } ], "gene_names_uniprotkb": "P2rx4", "gene_names_refseq": "P2rx4", "protein_names_uniprotkb": "P2X purinoceptor 4; ATP receptor; P2X4; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2X purinoceptor 4; P2X4; purinergic receptor P2X, ligand-gated ion channel 4", "tax_id": 10116, "disease": "congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:29659); (R-RNO-139853); (R-RNO-418346)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "12077178;12917686;15686495;15985462;24762105;24817123;25662851;28332633;34638832;35218450;35290938;35594248;39019229;7498461;8551329;8598206;8602843;8622997", "class_list": "", "function": "ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4. Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology. Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation. Also participates in basal T-cell activity without TCR/CD3 stimulation. Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC. Upon activation, drives microglia motility via the PI3K/Akt pathway. Could also function as an ATP-gated cation channel of lysosomal membranes., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7., [RefSeq, PubMed]; P2X4 Inhibition reduces microglia inflammation and apoptosis by NLRP3 and improves nervous system defects in rat brain trauma model., [RefSeq, PubMed]; P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors. Publication Status: Online-Only, [RefSeq, PubMed]; P2X4 receptors mediate induction of antioxidants, fibrogenic cytokines and ECM transcripts; in presence of replicating HCV in in vitro setting: An insight into role of P2X4 in fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The role of P2X4R in regulating CA1 hippocampal synaptic impairment in LPS-induced depression., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 10, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0045296 cadherin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030054 cell junction", "go_biological_process": "GO:1904141 positive regulation of microglial cell migration;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0050975 sensory perception of touch;GO:0002931 response to ischemia;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P51577-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51578-1", "uniprot_id": [ { "id": "P2RX5_RAT", "url": "https://www.uniprot.org/uniprot/P51578", "type": "external" } ], "mass": 51539.0, "length": 455, "protein_name": "P2X purinoceptor 5", "gene_name": "P2rx5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "P2rx5", "gene_names_refseq": "", "protein_names_uniprotkb": "P2X purinoceptor 5; ATP receptor; P2X5; Purinergic receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:113995); (R-RNO-139853); (R-RNO-418346)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10336430;17001079;31727741;8690069;8786426;9855626", "class_list": "", "function": "ATP-gated nonselective transmembrane cation channel (PubMed:8786426). Permeable to potassium, sodium and calcium (By similarity). Unlike other P2RX receptors, the P2X5 receptor is also permeable to chloride (By similarity). Acts as an important regulator of inflammatory-related bone loss and osteoclast multinucleation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A6HGI1;G3V8I0;Q64613", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0005244 voltage-gated monoatomic ion channel activity;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0036179 osteoclast maturation;GO:0010043 response to zinc ion;GO:0048630 skeletal muscle tissue growth;GO:0051592 response to calcium ion;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51578-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51579-1", "uniprot_id": [ { "id": "P2RX6_RAT", "url": "https://www.uniprot.org/uniprot/P51579", "type": "external" } ], "mass": 43422.0, "length": 389, "protein_name": "P2X purinoceptor 6", "gene_name": "P2rx6", "organism": "Rat", "refseq_name": "P2X purinoceptor 6", "refseq_ac": [ { "id": "NP_036853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036853", "type": "external" } ], "gene_names_uniprotkb": "P2rx6; P2rxl1", "gene_names_refseq": "P2rx6; P2rxl1; P2x6; Rnap2x6", "protein_names_uniprotkb": "P2X purinoceptor 6; ATP receptor; P2X6; P2XM; Purinergic receptor P2X-like 1; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2X purinoceptor 6; P2X6 receptor; P2XM; purinergic receptor P2X, ligand-gated ion channel, 6; purinergic receptor P2X-like 1 orphan receptor; purinergic receptor P2X6", "tax_id": 10116, "disease": "", "pathway": " (rno:25041); (R-RNO-139853); (R-RNO-418346)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10037762;10864944;12077178;15044628;15657042;16452399;17449665;21669492;22230887;24815693;25680470;27545450;8670303;8786426", "class_list": "", "function": "Acts as a modulatory subunit rather than a functional channel. Unlike other P2XRs members, P2RX6 does not seem to form functional homotrimers (PubMed:10037762). P2RX6 requires the presence of P2RX4 or P2RX2 to become functional at the cell surface (PubMed:10864944). P2RX6 can be translocated to the nucleus and functions as a nuclear regulator of post-transcriptional modifications in neurons (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; P2X(4) and P2X(6) purinoreceptors are present in the gut from birth and that they are differentially distributed among regions, [RefSeq, PubMed]; P2X4 and P2X6 proteins were expressed in a different way during rat small intestine development, showing a higher colocalization coefficient at age P30 in both intestine regions. Those results suggest that purinergic receptors may play a role in intestinal maturation, which is associated with age and intestinal region., [RefSeq, PubMed]; The P2X6 receptor subunit is widely expressed in neuropils in the whole gray matter except for the dorsal superficial layer of the dorsal horn., [RefSeq, PubMed]; The study explores the association of the phenotype of ATP-activated current with the genotype of P2X1-6 subunits in neurons innervating tooth-pulp., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "R9PXR5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity;GO:0005216 monoatomic ion channel activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0070588 calcium ion transmembrane transport;GO:0033198 response to ATP", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P51579-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51774-1", "uniprot_id": [ { "id": "EGR2_RAT", "url": "https://www.uniprot.org/uniprot/P51774", "type": "external" } ], "mass": 49849.0, "length": 470, "protein_name": "E3 SUMO-protein ligase EGR2", "gene_name": "Egr2", "organism": "Rat", "refseq_name": "E3 SUMO-protein ligase EGR2", "refseq_ac": [ { "id": "NP_446085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446085", "type": "external" } ], "gene_names_uniprotkb": "Egr2; Egr-2; Krox-20; Krox20", "gene_names_refseq": "Egr2; Krox20", "protein_names_uniprotkb": "E3 SUMO-protein ligase EGR2; 2.3.2.-; E3 SUMO-protein transferase ERG2; EGR-2; Early growth response protein 2; Zinc finger protein Krox-20", "protein_names_refseq": "E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; EGR-2; early growth response protein 2; zinc finger protein Krox-20", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); Charcot-Marie-Tooth disease type 1D (Disease Ontology:DOID:0110150); congenital hypomyelinating neuropathy 1 (Disease Ontology:DOID:0110195); motor peripheral neuropathy (Disease Ontology:DOID:2477); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:114090); (R-RNO-9031628)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10970821;27890615;29580816;36648143;8619872", "class_list": "", "function": "Analysis of consensus EGR-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis., [RefSeq, PubMed]; COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by up-regulating Krox20., [RefSeq, PubMed]; E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pregulation of Egr2 and Egr4 could demote the activation of JNK/c-JUN pathway and the expression of pro-inflammatory cytokines in MCAO rats, so that Egr2 and Egr4 might be potential targets for ischemic stroke in future, [RefSeq, PubMed]; Sequence-specific DNA-binding transcription factor (By similarity). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q54AG4", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0021569 rhombomere 3 development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007611 learning or memory;GO:0016925 protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P51774-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51842-1", "uniprot_id": [ { "id": "GUC2F_RAT", "url": "https://www.uniprot.org/uniprot/P51842", "type": "external" } ], "mass": 124411.0, "length": 1108, "protein_name": "Retinal guanylyl cyclase 2", "gene_name": "Gucy2f", "organism": "Rat", "refseq_name": "retinal guanylyl cyclase 2 precursor", "refseq_ac": [ { "id": "NP_446283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446283", "type": "external" } ], "gene_names_uniprotkb": "Gucy2f; Guc2f", "gene_names_refseq": "Gucy2f", "protein_names_uniprotkb": "Retinal guanylyl cyclase 2; 4.6.1.2; GC-F; Guanylate cyclase 2F, retinal; Guanylate cyclase F; RETGC-2; ROS-GC2; Rod outer segment membrane guanylate cyclase 2", "protein_names_refseq": "GC-F; RETGC-2; ROS-GC2; guanylate cyclase 2F, retinal; guanylate cyclase F; retinal guanylyl cyclase 2 precursor; retinal guanylyl cyclase 2; rod outer segment membrane guanylate cyclase 2", "tax_id": 10116, "disease": "Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (rno:116556); (R-RNO-2514859)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "7831337;9153227", "class_list": "", "function": "Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:7831337). May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042622 photoreceptor outer segment membrane;GO:0120200 rod photoreceptor outer segment;GO:0120202 rod photoreceptor disc membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51842-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51871-1", "uniprot_id": [ { "id": "CP4F6_RAT", "url": "https://www.uniprot.org/uniprot/P51871", "type": "external" } ], "mass": 61541.0, "length": 537, "protein_name": "Cytochrome P450 4F6", "gene_name": "Cyp4f6", "organism": "Rat", "refseq_name": "cytochrome P450 4F6", "refseq_ac": [ { "id": "NP_695230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695230", "type": "external" } ], "gene_names_uniprotkb": "Cyp4f6", "gene_names_refseq": "Cyp4f6", "protein_names_uniprotkb": "Cytochrome P450 4F6; 1.14.14.1; CYPIVF6", "protein_names_refseq": "CYPIVF6; cytochrome P450 4F6", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (rno:266689)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12646265;16182239;18847377;29393594;8554568", "class_list": "", "function": "CYP4F5 and CYP4F6, due to their capacities to metabolize LTB(4), may play important roles in modulating inflammatory response in the lung and to some extent in the brain, kidney, and testis, [RefSeq, PubMed]; CYP4Fs are regionally distributed in the spontaneously hypertensive rat (SHR) kidney with CYP4F1, 4F4, and 4F5 being more highly expressed in the renal cortex than medulla while CYP4F6 shows higher medullary expression., [RefSeq, PubMed]; The present study shows that traumatic brain injury (TBI) triggers inflammation and elicits changes in mRNA expression of CYP4Fs in the frontal and occipital lobes and the hippocampus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006691 leukotriene metabolic process;GO:0044281 small molecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P51871-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53817-1", "uniprot_id": [ { "id": "PLAT3_RAT", "url": "https://www.uniprot.org/uniprot/P53817", "type": "external" } ], "mass": 17749.0, "length": 160, "protein_name": "Phospholipase A and acyltransferase 3", "gene_name": "Plaat3", "organism": "Rat", "refseq_name": "phospholipase A and acyltransferase 3", "refseq_ac": [ { "id": "NP_058756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058756", "type": "external" } ], "gene_names_uniprotkb": "Plaat3; H-rev107; Hrasls3; Hrev107; Pla2g16; Rlp-3", "gene_names_refseq": "HRSL3; Hrasls3; Hrev107; Pla2g16; Plaat3; RLP-3", "protein_names_uniprotkb": "Phospholipase A and acyltransferase 3; 2.3.1.-; 3.1.1.32; 3.1.1.4; Group XVI phospholipase A2; H-rev 107 protein homolog; HRAS-like suppressor 3; HRSL3; RLP-3; Rat LRAT-like protein-3", "protein_names_refseq": "H-rev 107 protein homolog; HRAS-like suppressor 3; Hras-revertant gene 107 (expression down-regulated in HRAS-transformed rat 208F fibroblasts); LRAT-like protein-3; group XVI phospholipase A1/A2; group XVI phospholipase A2; phospholipase A and acyltransferase 3; phospholipase A2, group XVI", "tax_id": 10116, "disease": "seminoma (Disease Ontology:DOID:4440)", "pathway": " (rno:24913); (R-RNO-1482788); (R-RNO-1482801); (R-RNO-1482839); (R-RNO-1482922)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "17158102;18614531;19047760;8290259", "class_list": "", "function": "Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19047760). Shows phospholipase A1 (PLA1) and A2 (PLA2), ccatalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19047760). For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:17158102, PubMed:19047760). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (By similarity). Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity (By similarity). Plays a role in phospholipid metabolism and adipogenesis., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7X6T2", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0008289 lipid binding;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0016410 N-acyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:1903008 organelle disassembly;GO:0006641 triglyceride metabolic process;GO:0007031 peroxisome organization;GO:0016042 lipid catabolic process;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P53817-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54319-1", "uniprot_id": [ { "id": "PLAP_RAT", "url": "https://www.uniprot.org/uniprot/P54319", "type": "external" } ], "mass": 87084.0, "length": 795, "protein_name": "Phospholipase A-2-activating protein", "gene_name": "Plaa", "organism": "Rat", "refseq_name": "phospholipase A-2-activating protein", "refseq_ac": [ { "id": "NP_446318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446318", "type": "external" } ], "gene_names_uniprotkb": "Plaa; Plap", "gene_names_refseq": "PLA2P; Plaa; Plap", "protein_names_uniprotkb": "Phospholipase A-2-activating protein; PLA2P; PLAP", "protein_names_refseq": "phospholipase A-2-activating protein", "tax_id": 10116, "disease": "", "pathway": " (rno:116645)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15368540;16024570;22673903;24623140;7665086", "class_list": "", "function": "Cytosolic phospholipase A2 mRNA is expressed in rat injured spinal cord at 7 days after spinal cord injury., [RefSeq, PubMed]; PLAA is a specific activator of PLA2 in growth plate chondrocytes, suggesting that it mediates the membrane effect of 1alpha,25(OH)2D3, thereby modulating physiological response., [RefSeq, PubMed]; Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity). Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis., [UniProtKB, UniProtKB]; These data suggest that the ANG II-induced neointimal growth is mediated by the activation of Akt through a mechanism dependent on cPLA2 and PLD2 activation in balloon-injured rat carotid arteries., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding;GO:0016005 phospholipase A2 activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0010992 ubiquitin recycling;GO:0006954 inflammatory response;GO:0007399 nervous system development;GO:0016236 macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P54319-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54825-1", "uniprot_id": [ { "id": "LMIP_RAT", "url": "https://www.uniprot.org/uniprot/P54825", "type": "external" } ], "mass": 19637.0, "length": 173, "protein_name": "Lens fiber membrane intrinsic protein", "gene_name": "Lim2", "organism": "Rat", "refseq_name": "lens fiber membrane intrinsic protein", "refseq_ac": [ { "id": "NP_446223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446223", "type": "external" } ], "gene_names_uniprotkb": "Lim2", "gene_names_refseq": "Lim2; MP17; MP18; MP20; Mp19", "protein_names_uniprotkb": "Lens fiber membrane intrinsic protein; MP17; MP18; MP19; MP20", "protein_names_refseq": "lens fiber membrane intrinsic protein; lens intrinsic membrane protein 2, 19kDa", "tax_id": 10116, "disease": "cataract 19 multiple types (Disease Ontology:DOID:0110263); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:114903)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11532191;2584203;7679355;8137630", "class_list": "", "function": "MP20 ia a galectin-3 ligand, [RefSeq, PubMed]; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 2, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031982 vesicle", "go_biological_process": "GO:0043010 camera-type eye development;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P54825-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010101.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54848-1", "uniprot_id": [ { "id": "EMP1_RAT", "url": "https://www.uniprot.org/uniprot/P54848", "type": "external" } ], "mass": 17826.0, "length": 160, "protein_name": "Epithelial membrane protein 1", "gene_name": "Emp1", "organism": "Rat", "refseq_name": "epithelial membrane protein 1", "refseq_ac": [ { "id": "NP_036975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036975", "type": "external" } ], "gene_names_uniprotkb": "Emp1", "gene_names_refseq": "CL-20; EMP-1; ENP1MR; Emp1; TMP", "protein_names_uniprotkb": "Epithelial membrane protein 1; EMP-1; Tumor-associated membrane protein", "protein_names_refseq": "epithelial membrane protein 1; tumor-associated membrane protein", "tax_id": 10116, "disease": "", "pathway": " (rno:25314)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16036215;7499407", "class_list": "", "function": "This report is the first to indicate EMP-1 to be a junctional protein in the liver., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0032060 bleb assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P54848-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55272-1", "uniprot_id": [ { "id": "CDN2B_RAT", "url": "https://www.uniprot.org/uniprot/P55272", "type": "external" } ], "mass": 13749.0, "length": 130, "protein_name": "Cyclin-dependent kinase 4 inhibitor B", "gene_name": "Cdkn2b", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 4 inhibitor B", "refseq_ac": [ { "id": "NP_570825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570825", "type": "external" } ], "gene_names_uniprotkb": "Cdkn2b; Ink4", "gene_names_refseq": "Cdkn2b; p15", "protein_names_uniprotkb": "Cyclin-dependent kinase 4 inhibitor B; p14-INK4b; p15-INK4b", "protein_names_refseq": "Cyclin dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); p14-INK4b; p15-INK4b", "tax_id": 10116, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); chronic myelomonocytic leukemia (Disease Ontology:DOID:0080188); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); melanoma and neural system tumor syndrome (Disease Ontology:DOID:0111511); dysplastic nevus syndrome (Disease Ontology:DOID:10041); prostate cancer (Disease Ontology:DOID:10283); open-angle glaucoma (Disease Ontology:DOID:1067); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); myopia (Disease Ontology:DOID:11830); leukemia (Disease Ontology:DOID:1240); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); transitional cell carcinoma (Disease Ontology:DOID:2671); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); neurilemmoma (Disease Ontology:DOID:3192); germinoma (Disease Ontology:DOID:3304); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); renal cell carcinoma (Disease Ontology:DOID:4450); pancreatic carcinoma (Disease Ontology:DOID:4905); cholangiocarcinoma (Disease Ontology:DOID:4947); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); uterine carcinosarcoma (Disease Ontology:DOID:6171); hepatocellular carcinoma (Disease Ontology:DOID:684); familial melanoma (Disease Ontology:DOID:6846); neuroblastoma (Disease Ontology:DOID:769); chronic myeloid leukemia (Disease Ontology:DOID:8552); in situ carcinoma (Disease Ontology:DOID:8719); erythema infectiosum (Disease Ontology:DOID:8743); skin melanoma (Disease Ontology:DOID:8923); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25164); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559585); (R-RNO-69231)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "26921270;32080953;7546221;7712460", "class_list": "", "function": "Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity)., [UniProtKB]; The P15 gene mutation was significantly correlated with osteosarcoma formation and metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; The loss of Cdkn2a/2b, which are the most frequently lost foci in human MM, were observed in 8 cases of rat MM (homozygous deletion [5/8] and loss of heterozygosity [3/8]) by array-based comparative genomic hybridization techniques., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 48, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0031670 cellular response to nutrient;GO:0030858 positive regulation of epithelial cell differentiation;GO:0001889 liver development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55272-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56702-1", "uniprot_id": [ { "id": "DBIL5_RAT", "url": "https://www.uniprot.org/uniprot/P56702", "type": "external" } ], "mass": 9864.0, "length": 87, "protein_name": "Diazepam-binding inhibitor-like 5", "gene_name": "Dbil5", "organism": "Rat", "refseq_name": "diazepam-binding inhibitor-like 5", "refseq_ac": [ { "id": "NP_067607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067607", "type": "external" } ], "gene_names_uniprotkb": "Dbil5", "gene_names_refseq": "Dbil5; Elp", "protein_names_uniprotkb": "Diazepam-binding inhibitor-like 5; ELP; Endozepine-like peptide", "protein_names_refseq": "diazepam-binding inhibitor-like 5; endozepine-like peptide", "tax_id": 10116, "disease": "cardiovascular system disease (Disease Ontology:DOID:1287)", "pathway": " (rno:59116)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10415332", "class_list": "", "function": "May be involved in the energy metabolism of the mature sperm., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUJ9", "ec_number_list": [], "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56702-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56718-1", "uniprot_id": [ { "id": "OX1R_RAT", "url": "https://www.uniprot.org/uniprot/P56718", "type": "external" } ], "mass": 46800.0, "length": 416, "protein_name": "Orexin/Hypocretin receptor type 1", "gene_name": "Hcrtr1", "organism": "Rat", "refseq_name": "orexin/Hypocretin receptor type 1", "refseq_ac": [ { "id": "NP_037196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037196", "type": "external" } ], "gene_names_uniprotkb": "Hcrtr1", "gene_names_refseq": "Hcrtr1; Hctr1", "protein_names_uniprotkb": "Orexin/Hypocretin receptor type 1; Hypocretin receptor type 1; Orexin receptor type 1; Ox-1-R; Ox1-R; Ox1R", "protein_names_refseq": "hypocretin (orexin) receptor 1; hypocretin receptor type 1; orexin receptor type 1; orexin/Hypocretin receptor type 1; ox-1-R; ox1-R; ox1r", "tax_id": 10116, "disease": "", "pathway": " (rno:25593); (R-RNO-389397); (R-RNO-416476)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11102651;11298806;36284025;36470538;36539163;39056112;39119889;9491897", "class_list": "", "function": "A high-fat diet induced depression-like phenotype via hypocretin-HCRTR1 mediated inflammation activation. Publication Status: Online-Only, [RefSeq, PubMed]; Blockade of the orexin 1-receptors and 'cocaine- and amphetamine-regulated transcript' in the nucleus accumbens shell alters impulse control in rats., [RefSeq, PubMed]; Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats., [RefSeq, PubMed]; G protein-coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin. Its activity is mediated via a G(q)-protein-coupled pathway, which activates the phosphatidylinositol-calcium second messenger system in response to orexin-A binding. In addition to G(q)-mediated signaling, orexin-A stimulation also promotes beta-arrestin recruitment, leading to receptor internalization (By similarity). Plays a significant role in the regulation of food intake (PubMed:11102651, PubMed:11298806)., [UniProtKB, UniProtKB, PubMed, PubMed]; Hypocretin-1/Hypocretin Receptor 1 Regulates Neuroplasticity and Cognitive Function through Hippocampal Lactate Homeostasis in Depressed Model., [RefSeq, PubMed]; The Role of Orexin-1 Receptors Within the Hippocampal CA1 Area in the Extinction and Reinstatement of Methamphetamine-Seeking Behaviors., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017046 peptide hormone binding;GO:0016499 orexin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P56718-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56719-1", "uniprot_id": [ { "id": "OX2R_RAT", "url": "https://www.uniprot.org/uniprot/P56719", "type": "external" } ], "mass": 52489.0, "length": 460, "protein_name": "Orexin receptor type 2", "gene_name": "Hcrtr2", "organism": "Rat", "refseq_name": "orexin receptor type 2 isoform 1", "refseq_ac": [ { "id": "NP_037206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037206", "type": "external" } ], "gene_names_uniprotkb": "Hcrtr2", "gene_names_refseq": "Hcrtr2; ox-2-R; ox2-R; ox2r", "protein_names_uniprotkb": "Orexin receptor type 2; Hypocretin receptor type 2; Ox-2-R; Ox2-R; Ox2R", "protein_names_refseq": "hypocretin (orexin) receptor 2; hypocretin receptor type 2; orexin receptor type 2 isoform 1; orexin receptor type 2", "tax_id": 10116, "disease": "hyperglycemia (Disease Ontology:DOID:4195); narcolepsy (Disease Ontology:DOID:8986)", "pathway": " (rno:25605); (R-RNO-389397); (R-RNO-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11459774;31738930;32207079;34718063;36470538;37866644;9491897", "class_list": "", "function": "Blockade of the orexin-2 receptors within the ventral tegmental area facilitates the extinction and prevents the reinstatement of methamphetamine-seeking behavior., [RefSeq, PubMed]; Distinct roles for orexin-1 and orexin-2 receptors in the dentate gyrus of the hippocampus in the methamphetamine-seeking behavior in the rats., [RefSeq, PubMed]; G protein-coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin. Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G proteins thereby initiating distinct downstream signaling cascades (By similarity). Involved in regulating the sleep-wake cycle. Contributes to central regulation of glucose homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; G-protein coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin. Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G-proteins thereby initiating distinct downstream signaling cascades. Involved in regulating the sleep-wake cycle. Contributes to central regulation of glucose homeostasis., [UniProtKB, UniProtKB]; Mechanisms of orexin 2 receptor-mediated depolarization in the rat paraventricular nucleus of the hypothalamus., [RefSeq, PubMed]; Orexin receptor expression was studies in various tissues. OX2R is sexually dimorphic expressed in adrenal glands., [RefSeq, PubMed]; Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain., [RefSeq, PubMed]; The Effect of Orexin Receptor Antagonism on Quinpirole-Induced Compulsive-Like Checking Behavior in Rats., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017046 peptide hormone binding;GO:0016499 orexin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0032870 cellular response to hormone stimulus;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P56719-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56819-1", "uniprot_id": [ { "id": "BACE1_RAT", "url": "https://www.uniprot.org/uniprot/P56819", "type": "external" } ], "mass": 55807.0, "length": 501, "protein_name": "Beta-secretase 1", "gene_name": "Bace1", "organism": "Rat", "refseq_name": "beta-secretase 1 precursor", "refseq_ac": [ { "id": "NP_062077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062077", "type": "external" } ], "gene_names_uniprotkb": "Bace1; Bace", "gene_names_refseq": "Bace1; Bace", "protein_names_uniprotkb": "Beta-secretase 1; 3.4.23.46; ASP2; Asp 2; Aspartyl protease 2; Beta-site APP cleaving enzyme 1; Beta-site amyloid precursor protein cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2", "protein_names_refseq": "ASP2; asp 2; aspartyl protease 2; beta-secretase 1 precursor; beta-site APP cleaving enzyme 1; beta-site amyloid precursor protein cleaving enzyme 1; memapsin-2; membrane-associated aspartic protease 2", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); dementia (Disease Ontology:DOID:1307); alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); sensory peripheral neuropathy (Disease Ontology:DOID:2491); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:29392)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10531052;34225591;34585626;38215068;38227464", "class_list": "", "function": "Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3beta at Thr252 by in Vitro Studies., [RefSeq, PubMed]; Effect of Global Brain Ischemia on Amyloid Precursor Protein Metabolism and Expression of Amyloid-Degrading Enzymes in Rat Cortex: Role in Pathogenesis of Alzheimer's Disease., [RefSeq, PubMed]; MiR-29c-3p Attenuates beta-Amyloid-Induced Neurotoxicity in Alzheimer's Disease Through Regulating beta-Site Amyloid Precursor Protein-Cleaving Enzyme 1., [RefSeq, PubMed]; MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer's disease by downregulation of HNRNPU stabilized BACE1., [RefSeq, PubMed]; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). Cleaves CHL1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0019899 enzyme binding;GO:0001540 amyloid-beta binding;GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis;GO:0010288 response to lead ion;GO:0016485 protein processing;GO:0050435 amyloid-beta metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P56819-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57093-1", "uniprot_id": [ { "id": "PAHX_RAT", "url": "https://www.uniprot.org/uniprot/P57093", "type": "external" } ], "mass": 38588.0, "length": 338, "protein_name": "Phytanoyl-CoA dioxygenase, peroxisomal", "gene_name": "Phyh", "organism": "Rat", "refseq_name": "phytanoyl-CoA dioxygenase, peroxisomal precursor", "refseq_ac": [ { "id": "NP_446126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446126", "type": "external" } ], "gene_names_uniprotkb": "Phyh", "gene_names_refseq": "Phyh", "protein_names_uniprotkb": "Phytanoyl-CoA dioxygenase, peroxisomal; 1.14.11.18; PhyH; Phytanic acid oxidase; Phytanoyl-CoA alpha-hydroxylase", "protein_names_refseq": "phytanic acid oxidase; phytanoyl-CoA alpha-hydroxylase; phytanoyl-CoA dioxygenase, peroxisomal precursor; phytanoyl-CoA dioxygenase, peroxisomal; phytanoyl-CoA hydroxylase (Refsum disease)", "tax_id": 10116, "disease": "orofacial cleft (Disease Ontology:DOID:0050567); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Refsum disease (Disease Ontology:DOID:10582); Zellweger syndrome (Disease Ontology:DOID:905); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (rno:114209); (R-RNO-389599); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10588950;10744784;9326940", "class_list": "", "function": "Catalyzes the 2-hydroxylation of racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA (PubMed:10588950, PubMed:10744784). Shows activity also towards a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (By similarity). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl-and 4-methyl-branched acyl-CoAs (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QY64", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "1.14.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.18", "type": "external" }, { "id": "2.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.26", "type": "external" } ], "go_molecular_function": "GO:0003824 catalytic activity;GO:0031406 carboxylic acid binding;GO:0008198 ferrous iron binding;GO:0031418 L-ascorbic acid binding;GO:0048244 phytanoyl-CoA dioxygenase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0001561 fatty acid alpha-oxidation;GO:0006720 isoprenoid metabolic process;GO:0097089 methyl-branched fatty acid metabolic process;GO:0019606 2-oxobutyrate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P57093-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57756-1", "uniprot_id": [ { "id": "FCN2_RAT", "url": "https://www.uniprot.org/uniprot/P57756", "type": "external" } ], "mass": 34684.0, "length": 319, "protein_name": "Ficolin-2", "gene_name": "Fcn2; Fcnb", "organism": "Rat", "refseq_name": "ficolin-2 precursor", "refseq_ac": [ { "id": "NP_446086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446086", "type": "external" } ], "gene_names_uniprotkb": "Fcn2; Fcnb; Fcnb", "gene_names_refseq": "Fcn2; Fcnb", "protein_names_uniprotkb": "Ficolin-2; Collagen/fibrinogen domain-containing protein 2; Ficolin-B; Ficolin-beta; L-ficolin", "protein_names_refseq": "L-ficolin; collagen/fibrinogen domain-containing protein 2; ficolin-2 precursor; ficolin-2; ficolin-beta", "tax_id": 10116, "disease": "", "pathway": " (rno:114091); (R-RNO-2855086); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21182092", "class_list": "", "function": "Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Specifically binds N-Acetylglucosamine (GlcNAc), as well as phosphocholine and lipoteichoic acid moieties on the surface of pathogens., [UniProtKB, UniProtKB]; Rat ficolin-B activated MASP-2 comparable to ficolin-A., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0032757 positive regulation of interleukin-8 production;GO:0034394 protein localization to cell surface;GO:0001867 complement activation, lectin pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P57756-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60825-1", "uniprot_id": [ { "id": "CIRBP_RAT", "url": "https://www.uniprot.org/uniprot/P60825", "type": "external" } ], "mass": 18607.0, "length": 172, "protein_name": "Cold-inducible RNA-binding protein", "gene_name": "Cirbp", "organism": "Rat", "refseq_name": "cold-inducible RNA-binding protein isoform X2", "refseq_ac": [ { "id": "XP_006241077", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241077", "type": "external" } ], "gene_names_uniprotkb": "Cirbp; Cirp", "gene_names_refseq": "Cirbp", "protein_names_uniprotkb": "Cold-inducible RNA-binding protein; A18 hnRNP; Glycine-rich RNA-binding protein CIRP", "protein_names_refseq": "cold-inducible RNA-binding protein isoform X2", "tax_id": 10116, "disease": "", "pathway": " (rno:81825)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09069;O09148;Q61413", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0030371 translation repressor activity;GO:0003730 mRNA 3'-UTR binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0070417 cellular response to cold;GO:0048255 mRNA stabilization;GO:0030308 negative regulation of cell growth;GO:0009411 response to UV;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P60825-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61150-1", "uniprot_id": [ { "id": "FGF12_RAT", "url": "https://www.uniprot.org/uniprot/P61150", "type": "external" } ], "mass": 27399.0, "length": 243, "protein_name": "Fibroblast growth factor 12", "gene_name": "Fgf12", "organism": "Rat", "refseq_name": "fibroblast growth factor 12 isoform 2", "refseq_ac": [ { "id": "NP_001382013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382013", "type": "external" } ], "gene_names_uniprotkb": "Fgf12; Fhf1", "gene_names_refseq": "Fgf12; Fgf1a; Fhf1b; Fhf1", "protein_names_uniprotkb": "Fibroblast growth factor 12; FGF-12; FHF-1; Fibroblast growth factor homologous factor 1", "protein_names_refseq": "FGF-12; FHF-1; fibroblast growth factor 12 isoform 2; fibroblast growth factor 1a; fibroblast growth factor homologous factor 1b; fibroblast growth factor homologous factor 1", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425)", "pathway": " (rno:170630)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11376006;17678857;25724910;27470512;35093630", "class_list": "", "function": "FGF12 strongly induced the quiescent and contractile vascular smooth muscle cell phenotype and directly promoted VSMC lineage differentiation., [RefSeq, PubMed]; Fibroblast growth factor 12 is a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in the rat brain., [RefSeq, PubMed]; Involved in nervous system development and function. Promote neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation., [UniProtKB, UniProtKB]; MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in PC12 Cells., [RefSeq, PubMed]; Sodium channels in Fhf1-/-Fhf4-/- granule neurons inactivate at more negative membrane potential, inactivate more rapidly, and are slower to recover from the inactivated state., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35339;P70376;Q924B4;Q92912;Q93001", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0050905 neuromuscular process;GO:0007254 JNK cascade;GO:0007268 chemical synaptic transmission;GO:0010765 positive regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P61150-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61365-1", "uniprot_id": [ { "id": "OSTN_RAT", "url": "https://www.uniprot.org/uniprot/P61365", "type": "external" } ], "mass": 14636.0, "length": 132, "protein_name": "Osteocrin", "gene_name": "Ostn", "organism": "Rat", "refseq_name": "osteocrin precursor", "refseq_ac": [ { "id": "NP_997495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997495", "type": "external" } ], "gene_names_uniprotkb": "Ostn", "gene_names_refseq": "Ostn", "protein_names_uniprotkb": "Osteocrin; Musclin", "protein_names_refseq": "musclin; osteocrin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:360730)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14523025;15044443;17189616;17951249;23940802;33955191", "class_list": "", "function": "Decreased muscle-derived musclin by chronic resistance exercise is associated with improved insulin resistance in rats with type 2 diabetes., [RefSeq, PubMed]; Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production. Required to enhance physical endurance: induced following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C. May act as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle., [UniProtKB, UniProtKB]; Musclin is involved in blood pressure regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Musclin is produced by myocytes in a highly fiber-type specific manner and that physiological changes in type IIb myosin heavy chain lead to coordinated musclin expression., [RefSeq, PubMed]; Osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator., [RefSeq, PubMed]; Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0030154 cell differentiation;GO:0009755 hormone-mediated signaling pathway;GO:0001503 ossification;GO:0045668 negative regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P61365-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61376-1", "uniprot_id": [ { "id": "LHX5_RAT", "url": "https://www.uniprot.org/uniprot/P61376", "type": "external" } ], "mass": 44388.0, "length": 402, "protein_name": "LIM/homeobox protein Lhx5", "gene_name": "Lhx5", "organism": "Rat", "refseq_name": "LIM/homeobox protein Lhx5", "refseq_ac": [ { "id": "NP_620605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620605", "type": "external" } ], "gene_names_uniprotkb": "Lhx5; Lim-2; Lim2", "gene_names_refseq": "Lhx5", "protein_names_uniprotkb": "LIM/homeobox protein Lhx5; Homeobox protein LIM-2; LIM homeobox protein 5", "protein_names_refseq": "LIM homeobox protein 5; LIM/homeobox protein Lhx5; homeobox protein LIM-2", "tax_id": 10116, "disease": "", "pathway": " (rno:124451)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7528105", "class_list": "", "function": "Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P50459", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007267 cell-cell signaling;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61376-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61459-1", "uniprot_id": [ { "id": "PHS_RAT", "url": "https://www.uniprot.org/uniprot/P61459", "type": "external" } ], "mass": 12000.0, "length": 104, "protein_name": "Pterin-4-alpha-carbinolamine dehydratase", "gene_name": "Pcbd1", "organism": "Rat", "refseq_name": "pterin-4-alpha-carbinolamine dehydratase", "refseq_ac": [ { "id": "NP_001007602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007602", "type": "external" } ], "gene_names_uniprotkb": "Pcbd1; Dcoh; Pcbd", "gene_names_refseq": "DCoH; Pcbd1; Pcbd; Pcd; Phs; TCF1", "protein_names_uniprotkb": "Pterin-4-alpha-carbinolamine dehydratase; 4-alpha-hydroxy-tetrahydropterin dehydratase; 4.2.1.96; DCoH; Dimerization cofactor of HNF1; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; PCD; PHS; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase", "protein_names_refseq": "4-alpha-hydroxy-tetrahydropterin dehydratase; 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); dimerization cofactor of HNF1; phenylalanine hydroxylase-stimulating protein; pterin carbinolamine dehydratase; pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; pterin-4-alpha-carbinolamine dehydratase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); BH4-deficient hyperphenylalaninemia D (Disease Ontology:DOID:0081131); glaucoma (Disease Ontology:DOID:1686); morphine dependence (Disease Ontology:DOID:2560)", "pathway": " (rno:29700); (R-RNO-8964208)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10966642;1465414;1763325;21047120;7744010;8444860;8618906;8897596;9865610", "class_list": "", "function": "A point mutation at the DCoH1 tetramer interface, Thr 51 Ser, overcomes the dissociation barrier of the homotetramer and increases the interaction with HNF-1alpha., [RefSeq, PubMed]; Involved in tetrahydrobiopterin biosynthesis (PubMed:8444860, PubMed:8618906). Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (PubMed:8444860). Coactivator for HNF1A-dependent transcription (PubMed:1763325). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (PubMed:1763325). Also acts as a coactivator for HNF1B-dependent transcription (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. Also acts as a coactivator for HNF1B-dependent transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rat Pcbd1 is a moonlighting protein that has dehydratase activity in addition to functioning as a cofactor which regulates HNF1alpha., [RefSeq, PubMed]; This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. [provided by RefSeq, Jan 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70519;P80095;Q9D930", "ec_number_list": [ { "id": "4.2.1.96", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.96", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity;GO:0004505 phenylalanine 4-monooxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0043393 regulation of protein binding;GO:0006729 tetrahydrobiopterin biosynthetic process;GO:0006558 L-phenylalanine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P61459-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61794-1", "uniprot_id": [ { "id": "LPAR1_RAT", "url": "https://www.uniprot.org/uniprot/P61794", "type": "external" } ], "mass": 41119.0, "length": 364, "protein_name": "Lysophosphatidic acid receptor 1", "gene_name": "Lpar1", "organism": "Rat", "refseq_name": "lysophosphatidic acid receptor 1", "refseq_ac": [ { "id": "NP_446388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446388", "type": "external" } ], "gene_names_uniprotkb": "Lpar1; Edg2; Gpcr91; Lpa1", "gene_names_refseq": "Edg2; Lpar1", "protein_names_uniprotkb": "Lysophosphatidic acid receptor 1; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor Edg-2", "protein_names_refseq": "LPA receptor 1; LPA-1; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; lysophosphatidic acid receptor 1; lysophosphatidic acid receptor Edg-2", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:116744); (R-RNO-416476); (R-RNO-418594); (R-RNO-419408)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "22673903;26473723;27094551;28342860;34920725;38936540;9753172", "class_list": "", "function": "Data showed that lysophosphatidic acid receptors LPA1-3, are phosphoproteins whose phosphorylation state is modulated by the natural agonist, LPA. Publication Status: Online-Only, [RefSeq, PubMed]; Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes., [RefSeq, PubMed]; LPA1 signaling drives Schwann cell dedifferentiation in experimental autoimmune neuritis. Publication Status: Online-Only, [RefSeq, PubMed]; Lysophosphatidic acid and its receptor LPAR1, acting through the Rho-ROCK pathway, regulate P2X3 receptor in the development of both mechanical and spontaneous pain in bone cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to LPA. Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (By similarity). Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain., [UniProtKB, UniProtKB, UniProtKB]; The data suggest that the LPAR1 mutants perturb lysophosphatidic acid signaling in cancer tissues., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O88584;P56487;P70420;Q5FWS2;Q61130", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005543 phospholipid binding;GO:0001965 G-protein alpha-subunit binding;GO:0030165 PDZ domain binding;GO:0070915 lysophosphatidic acid receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P61794-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61805-1", "uniprot_id": [ { "id": "DAD1_RAT", "url": "https://www.uniprot.org/uniprot/P61805", "type": "external" } ], "mass": 12497.0, "length": 113, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1", "gene_name": "Dad1", "organism": "Rat", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 isoform 2", "refseq_ac": [ { "id": "NP_620265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620265", "type": "external" } ], "gene_names_uniprotkb": "Dad1", "gene_names_refseq": "Dad1", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; DAD-1; Defender against cell death 1; Oligosaccharyl transferase subunit DAD1", "protein_names_refseq": "DAD-1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 isoform 2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; oligosaccharyl transferase subunit DAD1", "tax_id": 10116, "disease": "", "pathway": " (rno:192275); (R-RNO-9768727); (R-RNO-9931295)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08552;O70364;P46966;P46968;Q96GB7", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A;GO:0160227 oligosaccharyltransferase complex B", "go_biological_process": "GO:0007584 response to nutrient;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0009101 glycoprotein biosynthetic process;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P61805-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62870-1", "uniprot_id": [ { "id": "ELOB_RAT", "url": "https://www.uniprot.org/uniprot/P62870", "type": "external" } ], "mass": 13170.0, "length": 118, "protein_name": "Elongin-B", "gene_name": "Elob", "organism": "Rat", "refseq_name": "elongin-B", "refseq_ac": [ { "id": "NP_112391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112391", "type": "external" } ], "gene_names_uniprotkb": "Elob; Tceb2", "gene_names_refseq": "Elob; Tceb2", "protein_names_uniprotkb": "Elongin-B; EloB; Elongin 18 kDa subunit; RNA polymerase II transcription factor SIII subunit B; SIII p18; Transcription elongation factor B polypeptide 2", "protein_names_refseq": "RNA polymerase II transcription factor SIII subunit B; SIII p18; elongin 18 kDa subunit; elongin-B; transcription elongation factor B (SIII) polypeptide 2 (18kD, elongin B); transcription elongation factor B (SIII), polypeptide 2; transcription elongation factor B polypeptide 2; transcription elongation factor B subunit 2", "tax_id": 10116, "disease": "", "pathway": " (rno:81807); (R-RNO-112382); (R-RNO-1234176); (R-RNO-674695); (R-RNO-6796648); (R-RNO-75955); (R-RNO-8951664); (R-RNO-9705462); (R-RNO-983168); (R-RNO-9954709)", "pathway_count": 10, "publication_count": 2, "publication_id_list": "7638163;8244996", "class_list": "", "function": "Core component of multiple cullin-2 and cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination of target proteins. By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. Component the von Hippel-Lindau ubiquitination complex CBC(VHL). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The ECS(ASB9) complex mediates ubiquitination and degradation of CKB. As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (By similarity). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (By similarity). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (By similarity). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63529;Q80W20", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0030891 VCB complex;GO:0005667 transcription regulator complex;GO:0031462 Cul2-RING ubiquitin ligase complex;GO:0031466 Cul5-RING ubiquitin ligase complex;GO:0070449 elongin complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62870-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62898-1", "uniprot_id": [ { "id": "CYC_RAT", "url": "https://www.uniprot.org/uniprot/P62898", "type": "external" } ], "mass": 11605.0, "length": 105, "protein_name": "Cytochrome c, somatic", "gene_name": "Cycs", "organism": "Rat", "refseq_name": "cytochrome c, somatic", "refseq_ac": [ { "id": "NP_036971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036971", "type": "external" } ], "gene_names_uniprotkb": "Cycs", "gene_names_refseq": "CYCSA; Cycs", "protein_names_uniprotkb": "Cytochrome c, somatic", "protein_names_refseq": "Cytochrome C, expressed in somatic tissues; cytochrome c, somatic", "tax_id": 10116, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); thrombocytopenia (Disease Ontology:DOID:1588); pancreatic cancer (Disease Ontology:DOID:1793); inclusion body myositis (Disease Ontology:DOID:3429); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (rno:25309); (R-RNO-111457); (R-RNO-111458); (R-RNO-111459); (R-RNO-111461); (R-RNO-2151201); (R-RNO-3299685); (R-RNO-5620971); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9627069); (R-RNO-9707564)", "pathway_count": 12, "publication_count": 10, "publication_id_list": "191069;25634059;25848832;26271974;2834389;29393594;30980393;33710703;6130852;6263917", "class_list": "", "function": "Data show that sirtuin 3 could inhibit cell apoptosis by reducing cytochrome C (CytC) release and inhibiting caspase-3 activation in cardiomyocyte models with calcium overload., [RefSeq, PubMed]; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain., [UniProtKB]; Hepatoprotective effect of the tyrosine kinase inhibitor nilotinib against cyclosporine-A induced liver injury in rats through blocking the Bax/Cytochrome C/caspase-3 apoptotic signaling pathway., [RefSeq, PubMed]; Heroin activates ATF3 and CytC via c-Jun N-terminal kinase pathways to mediate neuronal apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity)., [UniProtKB]; Results suggested that hepatocyte injury and liver dysfunction may be caused by inducing apoptosis via the PARP and Cyt C pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P00009;Q8C2S2", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0043293 apoptosome", "go_biological_process": "GO:0034465 response to carbon monoxide;GO:0010730 negative regulation of hydrogen peroxide biosynthetic process;GO:0002931 response to ischemia;GO:0006979 response to oxidative stress;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P62898-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63004-1", "uniprot_id": [ { "id": "LIS1_RAT", "url": "https://www.uniprot.org/uniprot/P63004", "type": "external" } ], "mass": 46670.0, "length": 410, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit alpha", "gene_name": "Pafah1b1", "organism": "Rat", "refseq_name": "platelet-activating factor acetylhydrolase IB subunit alpha", "refseq_ac": [ { "id": "NP_113951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113951", "type": "external" } ], "gene_names_uniprotkb": "Pafah1b1; Lis-1; Lis1; Pafaha", "gene_names_refseq": "LIS1; Pafah1b1", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit alpha; LIS-1; Lissencephaly-1 protein; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha", "protein_names_refseq": "LIS-1; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAF-AH beta; PAFAH alpha; lissencephaly-1 protein; platelet-activating factor acetylhydrolase IB subunit alpha; platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta)", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469); lissencephaly 1 (Disease Ontology:DOID:0112237); status epilepticus (Disease Ontology:DOID:1824); schizophrenia (Disease Ontology:DOID:5419); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:83572); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-5663220); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8854518); (R-RNO-9648025)", "pathway_count": 16, "publication_count": 11, "publication_id_list": "11001923;11056530;11056532;11163260;16144905;16481446;23551859;28000671;28576829;9459487;9660828", "class_list": "", "function": "Data show that axonal synthesis of Lis1 and p150Glued is required for the adjustment of retrograde transport to acutely changing neurotrophin signalling in the periphery of neurons. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that binding of Lis1 to DDB complex does not strongly disrupt processive motility along microtubules; motile DDB complex binds up to two Lis1 dimers; mutational analysis suggested that Lis1 binds directly to the dynein motor domains during DDB complex movement. (Lis1 = lissencephaly 1 protein; DDB complex = dynein-dynactin-BicD2 complex; BicD2 = bicaudal D homolog 2 protein), [RefSeq, PubMed]; LIS1 interacts with KIF5b and regulates mitochondrial axonal transport in both anterograde and retrograde directions. Erratum:[Traffic. 2013 Oct;14(10):1105-8], [RefSeq, PubMed]; Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (By similarity). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35592;P43035;P81692;Q9R2A6", "ec_number_list": [], "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000235 astral microtubule;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0007611 learning or memory;GO:0008344 adult locomotory behavior;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P63004-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63076-1", "uniprot_id": [ { "id": "FGF17_RAT", "url": "https://www.uniprot.org/uniprot/P63076", "type": "external" } ], "mass": 24924.0, "length": 216, "protein_name": "Fibroblast growth factor 17", "gene_name": "Fgf17", "organism": "Rat", "refseq_name": "fibroblast growth factor 17 isoform 1 precursor", "refseq_ac": [ { "id": "NP_062071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062071", "type": "external" } ], "gene_names_uniprotkb": "Fgf17", "gene_names_refseq": "Fgf17; Fgf6b", "protein_names_uniprotkb": "Fibroblast growth factor 17; FGF-17", "protein_names_refseq": "FGF-17; fibroblast growth factor 17 isoform 1 precursor; fibroblast growth factor 6b", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 20 with or without anosmia (Disease Ontology:DOID:0090082)", "pathway": " (rno:29368); (R-RNO-109704); (R-RNO-1257604); (R-RNO-190322); (R-RNO-190371); (R-RNO-190372); (R-RNO-190373); (R-RNO-190375); (R-RNO-5654219); (R-RNO-5654221); (R-RNO-5654227); (R-RNO-5654228); (R-RNO-5654687); (R-RNO-5654688); (R-RNO-5654689); (R-RNO-5654693); (R-RNO-5654695); (R-RNO-5654699); (R-RNO-5654700); (R-RNO-5654704); (R-RNO-5654706); (R-RNO-5654710); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5654720); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5658623); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 32, "publication_count": 1, "publication_id_list": "9514906", "class_list": "", "function": "Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70627", "ec_number_list": [], "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0030334 regulation of cell migration;GO:0022008 neurogenesis;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63076-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63077-1", "uniprot_id": [ { "id": "GBG8_RAT", "url": "https://www.uniprot.org/uniprot/P63077", "type": "external" } ], "mass": 7843.0, "length": 70, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8", "gene_name": "Gng8", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8", "refseq_ac": [ { "id": "NP_631924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631924", "type": "external" } ], "gene_names_uniprotkb": "Gng8; Gng9; Gngt9", "gene_names_refseq": "Gng8; Hg3e", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8; Gamma-9", "protein_names_refseq": "G-protein gamma 8 subunit; gamma-9; guanine nucleotide binding protein (G protein), gamma 8 subunit; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8; heterotrimeric guanine nucleotide-binding protein 3e", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:245986); (R-RNO-1296041); (R-RNO-202040); (R-RNO-381676); (R-RNO-392170); (R-RNO-392451); (R-RNO-400042); (R-RNO-4086398); (R-RNO-416476); (R-RNO-418594); (R-RNO-418597); (R-RNO-420092); (R-RNO-428930); (R-RNO-432040); (R-RNO-456926); (R-RNO-8964616); (R-RNO-9856530); (R-RNO-997272)", "pathway_count": 18, "publication_count": 1, "publication_id_list": "7896821", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit may have a very specific role in the development and turnover of olfactory and vomeronasal neurons., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P43426", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0043584 nose development;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007399 nervous system development;GO:0035176 social behavior;GO:0071444 cellular response to pheromone", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63077-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63156-1", "uniprot_id": [ { "id": "BARH1_RAT", "url": "https://www.uniprot.org/uniprot/P63156", "type": "external" } ], "mass": 35136.0, "length": 327, "protein_name": "BarH-like 1 homeobox protein", "gene_name": "Barhl1", "organism": "Rat", "refseq_name": "barH-like 1 homeobox protein", "refseq_ac": [ { "id": "NP_476450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476450", "type": "external" } ], "gene_names_uniprotkb": "Barhl1; Mbh2", "gene_names_refseq": "Barhl1; Barhl2; Mbh2", "protein_names_uniprotkb": "BarH-like 1 homeobox protein; Bar-class homeodomain protein MBH2; BarH-related homeobox protein 1", "protein_names_refseq": "BarH-like 2; bar-class homeodomain protein MBH2; barH-like 1 homeobox protein; barH-related homeobox protein 1", "tax_id": 10116, "disease": "triple-receptor negative breast cancer (Disease Ontology:DOID:0060081); Alzheimer's disease (Disease Ontology:DOID:10652); high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (rno:117232)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JK26", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001764 neuron migration;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P63156-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68101-1", "uniprot_id": [ { "id": "IF2A_RAT", "url": "https://www.uniprot.org/uniprot/P68101", "type": "external" } ], "mass": 36108.0, "length": 315, "protein_name": "Eukaryotic translation initiation factor 2 subunit 1", "gene_name": "Eif2s1", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 2 subunit 1", "refseq_ac": [ { "id": "NP_062229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062229", "type": "external" } ], "gene_names_uniprotkb": "Eif2s1; Eif2a", "gene_names_refseq": "Eif2s1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2-alpha", "protein_names_refseq": "EIF-2A; EIF-2alpha; eIF-2-alpha; eIF2-alpha; eukaryotic translation initiation factor 2 subunit 1 alpha; eukaryotic translation initiation factor 2 subunit 1", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); leukodystrophy (Disease Ontology:DOID:10579); Alzheimer's disease (Disease Ontology:DOID:10652); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:54318); (R-RNO-156827); (R-RNO-381042); (R-RNO-382556); (R-RNO-72649); (R-RNO-72695); (R-RNO-72702); (R-RNO-72731); (R-RNO-9840373)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "1346232;26120832;27338925;29289717;2948954;36438488", "class_list": "", "function": "C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2alpha. Publication Status: Online-Only, [RefSeq, PubMed]; Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (By similarity)., [UniProtKB, UniProtKB]; Results demonstrate the sensitivity of eukaryotic initiation factor 2alpha-subunit (eIF2alpha) to stimulant exposure. Amphetamine possesses the ability to stimulate eIF2alpha phosphorylation in striatal and medial prefrontal cortex neurons in vivo in a dopamine D1 and D2 receptor-dependent manner., [RefSeq, PubMed]; These results suggest a critical role of the mTOR/eIF2alpha pathway in hypoxic vascular remodeling and pulmonary arterial vascular smooth muscle cell proliferation of pulmonary hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; TorsinA was post-transcriptionally upregulated upon acute ER stress, suggesting a role in this response. Increased basal phosphorylation of eIF2alpha in DYT1 transgenic rats was associated with abnormal response to acute ER stress. Unbiased RNA-Seq-based transcriptomic analysis of embryonic brain tissue in heterozygous and homozygous DYT1 knockin mice confirmed presence of eIF2alpha dysregulation in the DYT1 brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05199", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity;GO:0160296 cap-dependent translation initiation factor activity;GO:0160297 IRES-mediated translation initiation factor activity", "go_cellular_component": "GO:0044207 translation initiation ternary complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0034605 cellular response to heat;GO:0046777 protein autophosphorylation;GO:0006413 translational initiation;GO:0034599 cellular response to oxidative stress;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P68101-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70583-1", "uniprot_id": [ { "id": "DUT_RAT", "url": "https://www.uniprot.org/uniprot/P70583", "type": "external" } ], "mass": 22003.0, "length": 205, "protein_name": "Deoxyuridine 5'-triphosphate nucleotidohydrolase", "gene_name": "Dut", "organism": "Rat", "refseq_name": "deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2", "refseq_ac": [ { "id": "NP_001035361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035361", "type": "external" } ], "gene_names_uniprotkb": "Dut; Dutp", "gene_names_refseq": "Dutp; Dut; PIP4", "protein_names_uniprotkb": "Deoxyuridine 5'-triphosphate nucleotidohydrolase; 3.6.1.23; PIP4; PPAR-interacting protein 4; dUTP pyrophosphatase; dUTPase", "protein_names_refseq": "PPAR-interacting protein 4; dUTP pyrophosphatase; dUTPase; deoxyuridine 5'-triphosphate nucleotidohydrolase isoform 2; deoxyuridine 5'-triphosphate nucleotidohydrolase", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:497778); (R-RNO-499943)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "28073829;8910358", "class_list": "", "function": "Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (By similarity). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (PubMed:8910358). Essential for embryonic development (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; DUT inhibition by two independent siRNAs increased apoptosis in beta-cells., [RefSeq, PubMed]; Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.23", "type": "external" } ], "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0032556 pyrimidine deoxyribonucleotide binding;GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0042975 peroxisome proliferator activated receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006226 dUMP biosynthetic process;GO:0006231 dTMP biosynthetic process;GO:0046081 dUTP catabolic process;GO:0001889 liver development;GO:0043254 regulation of protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70583-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70612-1", "uniprot_id": [ { "id": "CXCR1_RAT", "url": "https://www.uniprot.org/uniprot/P70612", "type": "external" } ], "mass": 39945.0, "length": 349, "protein_name": "C-X-C chemokine receptor type 1", "gene_name": "Cxcr1", "organism": "Rat", "refseq_name": "C-X-C chemokine receptor type 1", "refseq_ac": [ { "id": "NP_062183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062183", "type": "external" } ], "gene_names_uniprotkb": "Cxcr1; Il8ra", "gene_names_refseq": "Cxcr1; IL-8R A; Il8ra", "protein_names_uniprotkb": "C-X-C chemokine receptor type 1; CXC-R1; CXCR-1; High affinity interleukin-8 receptor A; IL-8R A", "protein_names_refseq": "C-X-C chemokine receptor type 1; chemokine (C-X-C motif) receptor 1; high affinity interleukin-8 receptor A; interleukin 8 receptor, alpha", "tax_id": 10116, "disease": "urinary tract infection (Disease Ontology:DOID:0080784); pyelonephritis (Disease Ontology:DOID:11400); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:54258); (R-RNO-380108); (R-RNO-418594); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "36227008;36796675;8955112", "class_list": "", "function": "CXCR1 participates in bone cancer pain induced by Walker 256 breast cancer cells in female rats., [RefSeq, PubMed]; Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1). Review article, [RefSeq, PubMed]; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0019959 interleukin-8 binding;GO:0004918 interleukin-8 receptor activity;GO:0016494 C-X-C chemokine receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0097648 G protein-coupled receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70612-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70668-1", "uniprot_id": [ { "id": "GUC2B_RAT", "url": "https://www.uniprot.org/uniprot/P70668", "type": "external" } ], "mass": 11573.0, "length": 106, "protein_name": "Guanylate cyclase activator 2B", "gene_name": "Guca2b", "organism": "Rat", "refseq_name": "guanylate cyclase activator 2B precursor", "refseq_ac": [ { "id": "NP_071620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071620", "type": "external" } ], "gene_names_uniprotkb": "Guca2b", "gene_names_refseq": "Guca2b", "protein_names_uniprotkb": "Guanylate cyclase activator 2B", "protein_names_refseq": "guanylate cyclase activator 2B precursor; guanylate cyclase activator 2b (retina); uroguanylin", "tax_id": 10116, "disease": "", "pathway": " (rno:64055); (R-RNO-8935690)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16814407;21106860;22952280;27044258;8977100;9094754;9176203", "class_list": "", "function": "Atrial natriuretic peptide, urodilatin, guanylin and uroguanylin interact in rat kidney, [RefSeq, PubMed]; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport., [UniProtKB]; Our data suggest that the inhibitory effect of UGN on NHE3 transport activity in proximal tubule is mediated by activation of both cGMP/PKG and cAMP/PKA signaling pathways, [RefSeq, PubMed]; The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines., [RefSeq, PubMed]; These studies provide a comprehensive description of Ugn and GC-C expression in the kidney of the Sprague-Dawley rat., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030250 guanylate cyclase activator activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0060612 adipose tissue development;GO:0045776 negative regulation of blood pressure;GO:0097009 energy homeostasis;GO:0035264 multicellular organism growth;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70668-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80431-1", "uniprot_id": [ { "id": "COX7B_RAT", "url": "https://www.uniprot.org/uniprot/P80431", "type": "external" } ], "mass": 8995.0, "length": 80, "protein_name": "Cytochrome c oxidase subunit 7B, mitochondrial", "gene_name": "Cox7b", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 7B, mitochondrial precursor", "refseq_ac": [ { "id": "NP_877971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877971", "type": "external" } ], "gene_names_uniprotkb": "Cox7b", "gene_names_refseq": "Cox7b", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7B, mitochondrial; Cytochrome c oxidase polypeptide VIIb", "protein_names_refseq": "cytochrome c oxidase polypeptide VIIb; cytochrome c oxidase subunit 7B, mitochondrial precursor; cytochrome c oxidase subunit 7B, mitochondrial; cytochrome c oxidase subunit VIIb", "tax_id": 10116, "disease": "linear skin defects with multiple congenital anomalies 2 (Disease Ontology:DOID:0111877)", "pathway": " (rno:303393); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "7601105", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity). Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AYA9;Q7TPH1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0007417 central nervous system development;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80431-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80433-1", "uniprot_id": [ { "id": "COX8A_RAT", "url": "https://www.uniprot.org/uniprot/P80433", "type": "external" } ], "mass": 7672.0, "length": 69, "protein_name": "Cytochrome c oxidase subunit 8A, mitochondrial", "gene_name": "Cox8a", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 8A, mitochondrial precursor", "refseq_ac": [ { "id": "NP_599172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599172", "type": "external" } ], "gene_names_uniprotkb": "Cox8a; Cox8l; Cox8", "gene_names_refseq": "Cox8a", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 8A, mitochondrial; Cytochrome c oxidase polypeptide VIII-liver; Cytochrome c oxidase subunit 8-2", "protein_names_refseq": "cytochrome c oxidase polypeptide VIII-liver; cytochrome c oxidase subunit 8-2; cytochrome c oxidase subunit 8A, mitochondrial precursor; cytochrome c oxidase subunit 8A, mitochondrial; cytochrome c oxidase subunit VIIIa", "tax_id": 10116, "disease": "mitochondrial complex IV deficiency nuclear type 15 (Disease Ontology:DOID:0070500)", "pathway": " (rno:171335); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "2822403;7601105", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JMZ9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P80433-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84850-1", "uniprot_id": [ { "id": "D2HDH_RAT", "url": "https://www.uniprot.org/uniprot/P84850", "type": "external" } ], "mass": 58805.0, "length": 535, "protein_name": "D-2-hydroxyglutarate dehydrogenase, mitochondrial", "gene_name": "D2hgdh", "organism": "Rat", "refseq_name": "D-2-hydroxyglutarate dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_001100396", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100396", "type": "external" } ], "gene_names_uniprotkb": "D2hgdh", "gene_names_refseq": "D2hgdh; RGD1307976", "protein_names_uniprotkb": "D-2-hydroxyglutarate dehydrogenase, mitochondrial; 1.1.99.39", "protein_names_refseq": "D-2-hydroxyglutarate dehydrogenase, mitochondrial", "tax_id": 10116, "disease": "D-2-hydroxyglutaric aciduria 1 (Disease Ontology:DOID:0111351); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:301624); (R-RNO-880009)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15070399", "class_list": "", "function": "Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (PubMed:15070399). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (PubMed:15070399). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (By similarity)., [UniProtKB, PubMed, UniProtKB]; Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.99.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.99.39", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0071949 FAD binding;GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0010043 response to zinc ion;GO:0010042 response to manganese ion;GO:0031648 protein destabilization;GO:0032025 response to cobalt ion;GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P84850-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85834-1", "uniprot_id": [ { "id": "EFTU_RAT", "url": "https://www.uniprot.org/uniprot/P85834", "type": "external" } ], "mass": 49522.0, "length": 452, "protein_name": "Elongation factor Tu, mitochondrial", "gene_name": "Tufm", "organism": "Rat", "refseq_name": "elongation factor Tu, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001099765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099765", "type": "external" } ], "gene_names_uniprotkb": "Tufm", "gene_names_refseq": "Tufm", "protein_names_uniprotkb": "Elongation factor Tu, mitochondrial; 3.6.5.3", "protein_names_refseq": "elongation factor Tu, mitochondrial precursor; elongation factor Tu, mitochondrial", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); combined oxidative phosphorylation deficiency 4 (Disease Ontology:DOID:0111494)", "pathway": " (rno:293481)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19343716;23041468;26446791;27213235;34502162;38843836", "class_list": "", "function": "GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation (By similarity). Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The mitochondrial responses to severe burn, and indicate a pathway by which decreased EF-Tumt expression mediates oxidative damage in postburn myocardium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0045202 synapse", "go_biological_process": "GO:0045471 response to ethanol;GO:0070125 mitochondrial translational elongation;GO:0006414 translational elongation;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P85834-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97534-1", "uniprot_id": [ { "id": "FKB1B_RAT", "url": "https://www.uniprot.org/uniprot/P97534", "type": "external" } ], "mass": 11795.0, "length": 108, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP1B", "gene_name": "Fkbp1b", "organism": "Rat", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP1B isoform 1", "refseq_ac": [ { "id": "NP_073166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073166", "type": "external" } ], "gene_names_uniprotkb": "Fkbp1b", "gene_names_refseq": "FKBP-12.6; FKBP-1B; Fkbp1b", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP1B; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; 5.2.1.8; Calstabin-2; FK506-binding protein 1B; FKBP-12.6; FKBP-1B; Immunophilin FKBP12.6; PPIase FKBP1B; Rotamase", "protein_names_refseq": "12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FK506-binding protein 1B; PPIase FKBP1B; calstabin-2; immunophilin FKBP12.6; peptidyl-prolyl cis-trans isomerase FKBP1B isoform 1; peptidyl-prolyl cis-trans isomerase FKBP1B; rotamase", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); catecholaminergic polymorphic ventricular tachycardia (Disease Ontology:DOID:0060674); Graves' disease (Disease Ontology:DOID:12361); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:58950); (R-RNO-2672351); (R-RNO-5578775)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "20431056;22363773;24053175;26224869;29255009;9013543", "class_list": "", "function": "A previously unrecognized genomic network modulating diverse brain structural processes is dysregulated by aging and restored by FKBP1b overexpression, [RefSeq, PubMed]; Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor 2 in bronchial smooth muscle cells is responsible for the increased calcium response contributing to AHR in asthma, [RefSeq, PubMed]; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Raising FKBP1b reversed calcium dysregulation and memory impairment in aging rats, allowing them to perform a memory task as well as young rats, [RefSeq, PubMed]; The effects of FKBP12.6 and another structurally similar molecule, FKBP12, which is far more abundant in heart, on the gating of single sheep RyR2 channels, were investigated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.16", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0030551 cyclic nucleotide binding;GO:0005102 signaling receptor binding;GO:0005246 calcium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0019855 calcium channel inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030018 Z disc;GO:0016529 sarcoplasmic reticulum;GO:0034704 calcium channel complex", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0050849 negative regulation of calcium-mediated signaling;GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0006939 smooth muscle contraction;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97534-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97535-1", "uniprot_id": [ { "id": "PLA1A_RAT", "url": "https://www.uniprot.org/uniprot/P97535", "type": "external" } ], "mass": 50202.0, "length": 456, "protein_name": "Phospholipase A1 member A", "gene_name": "Pla1a", "organism": "Rat", "refseq_name": "phospholipase A1 member A precursor", "refseq_ac": [ { "id": "NP_620237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620237", "type": "external" } ], "gene_names_uniprotkb": "Pla1a; Pspla1", "gene_names_refseq": "Pla1a; Ps-pla1; Pspla1", "protein_names_uniprotkb": "Phospholipase A1 member A; 3.1.1.111; PS-PLA1; Phosphatidylserine-specific phospholipase A1", "protein_names_refseq": "phosphatidylserine-specific phospholipase A1; phospholipase A1 member A precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:85311); (R-RNO-1482801)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11395520;8999922", "class_list": "", "function": "Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:8999922). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (PubMed:11395520). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (PubMed:8999922)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0008970 phospholipase A1 activity;GO:0120560 phosphatidylserine lysophospholipase activity;GO:0016298 lipase activity;GO:0052689 carboxylic ester hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0002080 acrosomal membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97535-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97546-2", "uniprot_id": [ { "id": "NPTN_RAT", "url": "https://www.uniprot.org/uniprot/P97546", "type": "external" } ], "mass": 43932.0, "length": 393, "protein_name": "Neuroplastin", "gene_name": "Nptn", "organism": "Rat", "refseq_name": "neuroplastin isoform 2 precursor", "refseq_ac": [ { "id": "NP_062253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062253", "type": "external" } ], "gene_names_uniprotkb": "Nptn; Sdfr1; Sdr1", "gene_names_refseq": "Nptn; SDR-1; Sdfr1", "protein_names_uniprotkb": "Neuroplastin; Glycoprotein 55/65; SDR-1; Stromal cell-derived receptor 1; gp55/65", "protein_names_refseq": "glycoprotein 55/65; glycoprotein 65; gp55/65; neuroplastin isoform 2 precursor; stromal cell derived factor receptor 1; stromal cell-derived receptor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:56064)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10.1039/D0MO00044B;10759566;16925595;19952283;22389504;24090084;24260123;34106099;38843836;8995369", "class_list": "", "function": "Accessory subunit of plasma membrane calcium-transporting ATPase ATP2B2/PMCA2 that stabilizes the transporter at the cell surface (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (By similarity). Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK (PubMed:10759566, PubMed:16925595). May also regulate neurite outgrowth by activating the FGFR1 signaling pathway (PubMed:10759566, PubMed:16925595). May play a role in synaptic plasticity (PubMed:10759566, PubMed:16925595). Promotes localization of XKR8 at the cell membrane (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Neuroplastin-65 can co-localize with a subset of GABA(A) receptor subtypes and might contribute to anchoring and/or confining GABA(A) receptors to particular synaptic or extra-synaptic sites, thus affecting receptor mobility and synaptic strength, [RefSeq, PubMed]; Neuroplastins act as key ancillary proteins for MCT2 cell surface localisation and activity in some neuronal populations, thus playing an important role in facilitating the uptake of lactate for use as a respiratory fuel. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 5, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 36, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "P97547;Q6IRE8", "ec_number_list": [], "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0044325 transmembrane transporter binding;GO:0050839 cell adhesion molecule binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0001934 positive regulation of protein phosphorylation;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008542 visual learning;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 5.3, "record_id": "P97546-2", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97947-1", "uniprot_id": [ { "id": "NR0B2_RAT", "url": "https://www.uniprot.org/uniprot/P97947", "type": "external" } ], "mass": 28750.0, "length": 260, "protein_name": "Nuclear receptor subfamily 0 group B member 2", "gene_name": "Nr0b2", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 0 group B member 2", "refseq_ac": [ { "id": "NP_476474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476474", "type": "external" } ], "gene_names_uniprotkb": "Nr0b2; Shp", "gene_names_refseq": "Nr0b2; Shp", "protein_names_uniprotkb": "Nuclear receptor subfamily 0 group B member 2; Orphan nuclear receptor SHP; Small heterodimer partner", "protein_names_refseq": "nuclear receptor subfamily 0 group B member 2; orphan nuclear receptor SHP; small heterodimer partner homologue", "tax_id": 10116, "disease": "alcoholic hepatitis (Disease Ontology:DOID:12351); intrahepatic cholestasis (Disease Ontology:DOID:1852); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:117274); (R-RNO-383280)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12842887;15721253;15976031;27485016;29028359;9003453", "class_list": "", "function": "It has been demonstrated that hepatic gene expression of Shp is directed by daily rhythm in food intake but not day/night rhythm., [RefSeq, PubMed]; Orphan receptor small heterodimer partner expression is regulated by estrogen receptor alpha, [RefSeq, PubMed]; SHP promoted SUMO1 attachment to LXRbeta by stabilizing the E3 SUMO ligase PIAS1. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0003714 transcription corepressor activity;GO:0044877 protein-containing complex binding;GO:0042974 nuclear retinoic acid receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97947-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00939-1", "uniprot_id": [ { "id": "FOXG1_RAT", "url": "https://www.uniprot.org/uniprot/Q00939", "type": "external" } ], "mass": 51466.0, "length": 480, "protein_name": "Forkhead box protein G1", "gene_name": "Foxg1", "organism": "Rat", "refseq_name": "forkhead box protein G1", "refseq_ac": [ { "id": "NP_036692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036692", "type": "external" } ], "gene_names_uniprotkb": "Foxg1; Fkhl1; Foxg1b", "gene_names_refseq": "BF1A; Fkhl1; Foxg1; RATBF1A", "protein_names_uniprotkb": "Forkhead box protein G1; BF-1; BF1; Brain factor 1; Forkhead-related protein FKHL1; FoxG1", "protein_names_refseq": "BF1; brain factor 1; forkhead box protein G1; forkhead-like transcription factor BF-1; forkhead-related protein FKHL1", "tax_id": 10116, "disease": "congenital variant of Rett syndrome (Disease Ontology:DOID:0070657); Rett syndrome (Disease Ontology:DOID:1206)", "pathway": " (rno:24370); (R-RNO-9617828)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1350202;22354967;31731101", "class_list": "", "function": "TLE1 cooperates with FoxG1 to promote neuronal survival in a CK2- and PI3K-Akt-dependent manner., [RefSeq, PubMed]; The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways., [RefSeq, PubMed]; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016199 axon midline choice point recognition;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q00939-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01728-1", "uniprot_id": [ { "id": "NAC1_RAT", "url": "https://www.uniprot.org/uniprot/Q01728", "type": "external" } ], "mass": 108185.0, "length": 971, "protein_name": "Sodium/calcium exchanger 1", "gene_name": "Slc8a1", "organism": "Rat", "refseq_name": "sodium/calcium exchanger 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001257701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257701", "type": "external" } ], "gene_names_uniprotkb": "Slc8a1; Ncx1", "gene_names_refseq": "Ncx1; Ncx; Slc8a1", "protein_names_uniprotkb": "Sodium/calcium exchanger 1; Na(+)/Ca(2+)-exchange protein 1; Solute carrier family 8 member 1", "protein_names_refseq": "Na(+)/Ca(2+)-exchange protein 1; Na-Ca exchanger; sodium/calcium exchanger 1 isoform 2 precursor; sodium/calcium exchanger 1; solute carrier family 8 (sodium/calcium exchanger), member 1; solute carrier family 8 member 1", "tax_id": 10116, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:29715); (R-RNO-418359); (R-RNO-425561); (R-RNO-5578775)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10894800;12502557;1415740;15040000;16914199;23506867;34995919;35022040;37032493;37918704;38679350;8195112;8255180;8276763;8422940;8454039;8798769", "class_list": "", "function": "Abnormal expression and role of MicroRNA-214-3p/SLC8A1 in neonatal Hypoxic-Ischaemic encephalopathy., [RefSeq, PubMed]; CircNCX1 modulates cardiomyocyte proliferation through promoting ubiquitination of BRG1., [RefSeq, PubMed]; Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy., [RefSeq, PubMed]; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:10894800, PubMed:12502557, PubMed:8422940, PubMed:8454039). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons., [RefSeq, PubMed]; Na(+)/Ca(2+) exchanger isoform 1 takes part to the Ca(2+)-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-L-alanine. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q924Y2;Q9QW49;Q9R238;Q9R239;Q9WU29;Q9WU30", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0005432 calcium:sodium antiporter activity;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:1902532 negative regulation of intracellular signal transduction;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007584 response to nutrient;GO:0071320 cellular response to cAMP;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q01728-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02759-1", "uniprot_id": [ { "id": "LOX15_RAT", "url": "https://www.uniprot.org/uniprot/Q02759", "type": "external" } ], "mass": 75378.0, "length": 663, "protein_name": "Polyunsaturated fatty acid lipoxygenase ALOX15", "gene_name": "Alox15", "organism": "Rat", "refseq_name": "polyunsaturated fatty acid lipoxygenase ALOX15", "refseq_ac": [ { "id": "NP_112272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112272", "type": "external" } ], "gene_names_uniprotkb": "Alox15; Alox12l", "gene_names_refseq": "12-LOX; 15-LOX; Alox12l; Alox12; Alox15", "protein_names_uniprotkb": "Polyunsaturated fatty acid lipoxygenase ALOX15; 1.13.11.-; 1.13.11.12; 1.13.11.31; 1.13.11.33; 12-LOX; 12/15-lipoxygenase; 15-LOX; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate 15-lipoxygenase; Arachidonate omega-6 lipoxygenase; Hepoxilin A3 synthase Alox15; Linoleate 13S-lipoxygenase", "protein_names_refseq": "12/15-LOX; 12/15-lipoxygenase; arachidonate 12-lipoxygenase, leukocyte-type; arachidonate omega-6 lipoxygenase; hepoxilin A3 synthase Alox15; linoleate 13S-lipoxygenase; polyunsaturated fatty acid lipoxygenase ALOX15", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); brain ischemia (Disease Ontology:DOID:2316); glomerulonephritis (Disease Ontology:DOID:2921); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:81639); (R-RNO-2142691); (R-RNO-2142712); (R-RNO-2142770); (R-RNO-9018677); (R-RNO-9018681); (R-RNO-9018896); (R-RNO-9023661); (R-RNO-9025106); (R-RNO-9026286)", "pathway_count": 10, "publication_count": 9, "publication_id_list": "15123652;22673903;23382512;28024685;28181190;36529997;38396985;8117750;8444196", "class_list": "", "function": "Alox15 processing of DHA contributes to production of resolvin D1 and LTP at hippocampo-prefrontal cortical synapses and associated spatial working memory performance., [RefSeq, PubMed]; Consistent with the decreases in the 15-LOX metabolites, expression levels of the genes that encode the 15-LOXs, Alox15 and Alox15b, were largely reduced in Olmsted syndrome model rats., [RefSeq, PubMed]; Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:15123652, PubMed:23382512, PubMed:8117750, PubMed:8444196). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:15123652, PubMed:23382512, PubMed:8117750, PubMed:8444196). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (PubMed:15123652, PubMed:23382512). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (By similarity). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Photothermal lipolysis accelerates ECM production via macrophage-derived ALOX15-mediated p38 MAPK activation in fibroblasts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MA51", "ec_number_list": [ { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.31", "type": "external" }, { "id": "1.13.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.33", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" } ], "go_molecular_function": "GO:0019870 potassium channel inhibitor activity;GO:0005506 iron ion binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0016165 linoleate 13S-lipoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0046456 icosanoid biosynthetic process;GO:0034440 lipid oxidation;GO:0006629 lipid metabolic process;GO:0042391 regulation of membrane potential;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q02759-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03061-7", "uniprot_id": [ { "id": "CREM_RAT", "url": "https://www.uniprot.org/uniprot/Q03061", "type": "external" } ], "mass": 38497.0, "length": 357, "protein_name": "cAMP-responsive element modulator", "gene_name": "Crem", "organism": "Rat", "refseq_name": "cAMP-responsive element modulator isoform 3", "refseq_ac": [ { "id": "NP_001104330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104330", "type": "external" } ], "gene_names_uniprotkb": "Crem", "gene_names_refseq": "Crem; Icer", "protein_names_uniprotkb": "cAMP-responsive element modulator", "protein_names_refseq": "CRE modulator; cAMP responsive element moderator; cAMP-responsive element modulator isoform 3; inducible cyclic AMP early repressor", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25620)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11089521;1461747;22673903;25381014;25517116;27234251;28439100;30118718;7515286", "class_list": "", "function": "CREM/ICER is a negative regulator of endothelial function, [RefSeq, PubMed]; Expression levels of ICER and BDNF were increased remarkably but the GABAA R alpha1 subunit decreased significantly in the drug-resistant epileptic rats. However, the expression levels of ICER, BDNF were decreased and the expression of the GABAA R alpha1 subunit increased significantly in the drug-resistant epileptic rats after two weeks of Hip-LFS., [RefSeq, PubMed]; The ERK1/2 and ICER-mediated feed forward loop is the hidden design principle underlying the switching role of beta-adrenergic receptor signaling in cell survival or death decision of cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; These data suggest that fluoride can impair male reproduction by affecting expression of P450, CREM, and ACT in the testes., [RefSeq, PubMed]; Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform Delta is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform Tau (activator) to CRE is increased by CREB3L4. The CREM isoform Tau-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (By similarity)., [UniProtKB]; Using an ADHD rat model, we demonstrate that impulsive animals are neurochemically and behaviorally more sensitive to heroin and exhibit reduced Crem expression in the nucleus accumbens core., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AYV1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006631 fatty acid metabolic process;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q03061-7", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03190-1", "uniprot_id": [ { "id": "CXA4_RAT", "url": "https://www.uniprot.org/uniprot/Q03190", "type": "external" } ], "mass": 37556.0, "length": 333, "protein_name": "Gap junction alpha-4 protein", "gene_name": "Gja4", "organism": "Rat", "refseq_name": "gap junction alpha-4 protein", "refseq_ac": [ { "id": "NP_067686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067686", "type": "external" } ], "gene_names_uniprotkb": "Gja4; Cxn-37", "gene_names_refseq": "CXN37; Cxnh1; Gja4", "protein_names_uniprotkb": "Gap junction alpha-4 protein; Connexin-37; Cx37", "protein_names_refseq": "Gap junction membrane channel, protein alpha 4 (connexin 37); connexin h1; connexin-37; cx37; gap junction alpha-4 protein; gap junction membrane channel protein alpha 4", "tax_id": 10116, "disease": "coronary artery disease (Disease Ontology:DOID:3393); ureteral obstruction (Disease Ontology:DOID:5199); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:25655); (R-RNO-190861)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11978404;1370487;24269759;25217644;28818996;29049831;30736283;32350069", "class_list": "", "function": "7,12-Dimethylbenz[a]anthracene increases Cx37 and Cx43 expression prior to follicle loss and during follicle loss both Cx37 and Cx43 expressions are reduced in cultured rat ovaries., [RefSeq, PubMed]; Cx37-N55I and -Q58L mutations formed hemichannels with behavior and permeation properties similar to Cx37-WT (especially Q58L), but none of the mutants suppressed rat insulinoma cell proliferation., [RefSeq, PubMed]; FFR levels increased along with decreased doses of siRNA CX37 lentivirus, indicating that siRNA CX37 lentivirus may reduce the risk of coronary atherosclerosis and provide a potential approach to treat coronary heart disease., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]; Serine 319 phosphorylation is necessary and sufficient to induce a Cx37 conformation that leads to arrested cell cycling. Publication Status: Online-Only, [RefSeq, PubMed]; Substituting alanine at serine residues 275, 302 and 328 eliminated Cx37-induced cell death, supported proliferation and reduced the GJCh closed state probability., [RefSeq, PubMed]; Upregulation of connexin 37 mRNA after sciatic nerve injury causes thermal hyperalgesia; gap junctions thus may be responsible for this hyperexcitability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005921 gap junction;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0006816 calcium ion transport;GO:0001568 blood vessel development;GO:0048265 response to pain;GO:0003158 endothelium development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q03190-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05095-1", "uniprot_id": [ { "id": "CDX1_RAT", "url": "https://www.uniprot.org/uniprot/Q05095", "type": "external" } ], "mass": 14300.0, "length": 123, "protein_name": "Homeobox protein CDX-1", "gene_name": "Cdx1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdx1; Cdx-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein CDX-1; Caudal-type homeobox protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:364883)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1360907", "class_list": "", "function": "Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008327 methyl-CpG binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0060349 bone morphogenesis;GO:0007389 pattern specification process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05095-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05096-1", "uniprot_id": [ { "id": "MYO1B_RAT", "url": "https://www.uniprot.org/uniprot/Q05096", "type": "external" } ], "mass": 131918.0, "length": 1136, "protein_name": "Unconventional myosin-Ib", "gene_name": "Myo1b", "organism": "Rat", "refseq_name": "unconventional myosin-Ib isoform 1", "refseq_ac": [ { "id": "NP_446438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446438", "type": "external" } ], "gene_names_uniprotkb": "Myo1b; Myo1a; Myr1", "gene_names_refseq": "MMI-alpha; MMIa; Myo1b; Myr1", "protein_names_uniprotkb": "Unconventional myosin-Ib; MMI-alpha; MMIa; Myosin I alpha; Myosin heavy chain myr 1", "protein_names_refseq": "myosin I alpha; myosin heavy chain myr 1; unconventional myosin-Ib isoform 1; unconventional myosin-Ib", "tax_id": 10116, "disease": "", "pathway": " (rno:117057)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "26940917;33826361;33930467;8449985", "class_list": "", "function": "Expression of myosin 1b constructs influenced secretory vesicle compression rate in alveolar type II cells, [RefSeq, PubMed]; In pancreatic beta-cells myosin 1b regulates glucose-stimulated insulin secretion by modulating an early step in insulin granule trafficking from the Golgi., [RefSeq, PubMed]; Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The C-terminal tail extension of myosin 16 acts as a molten globule, including intrinsically disordered regions, and interacts with the N-terminal ankyrin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007399 nervous system development;GO:0051017 actin filament bundle assembly;GO:0030048 actin filament-based movement", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q05096-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05820-1", "uniprot_id": [ { "id": "LYSC2_RAT", "url": "https://www.uniprot.org/uniprot/Q05820", "type": "external" } ], "mass": 16618.0, "length": 148, "protein_name": "Putative lysozyme C-2", "gene_name": "Lyz2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lyz2", "gene_names_refseq": "", "protein_names_uniprotkb": "Putative lysozyme C-2; 1,4-beta-N-acetylmuramidase C; 3.2.1.17", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8081549", "class_list": "glycogene;glycosylhydrolase", "function": "Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. In the intestine they may also have a digestive function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05820-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06437-1", "uniprot_id": [ { "id": "ODPAT_RAT", "url": "https://www.uniprot.org/uniprot/Q06437", "type": "external" } ], "mass": 43393.0, "length": 391, "protein_name": "Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial", "gene_name": "Pdha2", "organism": "Rat", "refseq_name": "pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor", "refseq_ac": [ { "id": "NP_446446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446446", "type": "external" } ], "gene_names_uniprotkb": "Pdha2", "gene_names_refseq": "Pdha2; Pdhal", "protein_names_uniprotkb": "Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; 1.2.4.1; PDHE1-A type II", "protein_names_refseq": "PDHE1-A type II; pyruvate dehydrogenase (lipoamide) alpha 2; pyruvate dehydrogenase E1 alpha 2 subunit; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; pyruvate dehydrogenase alpha 2", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); spermatogenic failure 70 (Disease Ontology:DOID:0070569); pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:117098); (R-RNO-204174); (R-RNO-5362517); (R-RNO-9861559)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "22673903;7916643;9787790", "class_list": "", "function": "The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle., [UniProtKB, PubMed]; Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex in testis. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) (By similarity). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2 (PubMed:9787790)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q06437-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07071-1", "uniprot_id": [ { "id": "GCKR_RAT", "url": "https://www.uniprot.org/uniprot/Q07071", "type": "external" } ], "mass": 68917.0, "length": 627, "protein_name": "Glucokinase regulatory protein", "gene_name": "Gckr", "organism": "Rat", "refseq_name": "glucokinase regulatory protein", "refseq_ac": [ { "id": "NP_037252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037252", "type": "external" } ], "gene_names_uniprotkb": "Gckr", "gene_names_refseq": "GKRP; GLRE; Gckr", "protein_names_uniprotkb": "Glucokinase regulatory protein; Glucokinase regulator", "protein_names_refseq": "68-kDa regulatory protein; glucokinase (hexokinase 4) regulator; glucokinase regulatory protein", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25658); (R-RNO-170822)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10456334;10518020;10601273;16542652;22044397;23957911;7682971;8112473", "class_list": "", "function": "Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23957911). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23957911)., [UniProtKB, PubMed, PubMed]; When GK is pre-incubated with glucose and compound A, the inhibition observed by GKRP is time dependent, but independent of GKRP concentration, reflecting the GKA-controlled transition between closed and open GK conformations., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0004857 enzyme inhibitor activity;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046415 urate metabolic process;GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0034504 protein localization to nucleus;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q07071-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07490-1", "uniprot_id": [ { "id": "CD24_RAT", "url": "https://www.uniprot.org/uniprot/Q07490", "type": "external" } ], "mass": 7862.0, "length": 76, "protein_name": "Signal transducer CD24", "gene_name": "Cd24", "organism": "Rat", "refseq_name": "signal transducer CD24 precursor", "refseq_ac": [ { "id": "NP_036884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036884", "type": "external" } ], "gene_names_uniprotkb": "Cd24; Cd24a", "gene_names_refseq": "Cd24a; Cd24", "protein_names_uniprotkb": "Signal transducer CD24; HSA; Heat-stable antigen; Nectadrin", "protein_names_refseq": "CD24 antigen; HSA; heat-stable antigen; nectadrin heat stable antigen; signal transducer CD24 precursor; signal transducer CD24", "tax_id": 10116, "disease": "multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (rno:25145)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21323829;26935354;29393594;8292828;9004038", "class_list": "", "function": "Here we show that Plasmodium berghei ANKA infection of young rats leads to the modulation of expression of CD24. Susceptibility to malaria infection seems to be mediated by the alteration of genes expressing CD24., [RefSeq, PubMed]; May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results suggested that Foxo1 overexpression in betacells was able to increase apoptosis by inhibiting CD24 expression. This study may provide an approach for the treatment and prevention of type 2 diabetes., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5T1", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030246 carbohydrate binding;GO:0030296 protein tyrosine kinase activator activity;GO:0051879 Hsp90 protein binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007155 cell adhesion;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0016477 cell migration;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q07490-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08125-1", "uniprot_id": [ { "id": "IL5_RAT", "url": "https://www.uniprot.org/uniprot/Q08125", "type": "external" } ], "mass": 15207.0, "length": 132, "protein_name": "Interleukin-5", "gene_name": "Il5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il5; Il-5", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-5; B-cell growth factor II; BCGF-II; Cytotoxic T-lymphocyte inducer; Eosinophil differentiation factor; IL-5; T-cell replacing factor; TRF", "protein_names_refseq": "", "tax_id": 10116, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); developmental disorder of mental health (Disease Ontology:DOID:0060037); benign neoplasm (Disease Ontology:DOID:0060072); chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); chronic lymphocytic leukemia (Disease Ontology:DOID:1040); stomach cancer (Disease Ontology:DOID:10534); IgA vasculitis (Disease Ontology:DOID:11123); prostatic hypertrophy (Disease Ontology:DOID:11132); nephrotic syndrome (Disease Ontology:DOID:1184); urinary schistosomiasis (Disease Ontology:DOID:1394); peptic esophagitis (Disease Ontology:DOID:13976); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); cancer (Disease Ontology:DOID:162); asthma (Disease Ontology:DOID:2841); invasive ductal carcinoma (Disease Ontology:DOID:3008); food allergy (Disease Ontology:DOID:3044); Churg-Strauss syndrome (Disease Ontology:DOID:3049); carcinoma (Disease Ontology:DOID:305); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); middle cerebral artery infarction (Disease Ontology:DOID:3525); eosinophilic gastroenteritis (Disease Ontology:DOID:4031); allergic rhinitis (Disease Ontology:DOID:4481); esophageal cancer (Disease Ontology:DOID:5041); kidney disease (Disease Ontology:DOID:557); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); systemic lupus erythematosus (Disease Ontology:DOID:9074); status asthmaticus (Disease Ontology:DOID:9362); pulmonary eosinophilia (Disease Ontology:DOID:9498)", "pathway": " (R-RNO-512988); (R-RNO-5673001); (R-RNO-912526)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10446387;1653053", "class_list": "", "function": "Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:10446387). Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005137 interleukin-5 receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045645 positive regulation of eosinophil differentiation;GO:0038043 interleukin-5-mediated signaling pathway;GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08125-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09QM4-1", "uniprot_id": [ { "id": "GPR17_RAT", "url": "https://www.uniprot.org/uniprot/Q09QM4", "type": "external" } ], "mass": 37870.0, "length": 339, "protein_name": "Uracil nucleotide/cysteinyl leukotriene receptor", "gene_name": "Gpr17", "organism": "Rat", "refseq_name": "uracil nucleotide/cysteinyl leukotriene receptor", "refseq_ac": [ { "id": "NP_001065245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001065245", "type": "external" } ], "gene_names_uniprotkb": "Gpr17", "gene_names_refseq": "Gpr17", "protein_names_uniprotkb": "Uracil nucleotide/cysteinyl leukotriene receptor; G protein-coupled receptor 17; UDP/CysLT receptor", "protein_names_refseq": "UDP/CysLT receptor; uracil nucleotide/cysteinyl leukotriene receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:767613); (R-RNO-391906); (R-RNO-416476); (R-RNO-417957); (R-RNO-418594)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "16990797;20056144;21209081;22155652;29187582;30226562;32387084;34569901;34769111", "class_list": "", "function": "Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia., [UniProtKB, PubMed]; GPR17 might mediate acute neuronal injury and late microgliosis after focal cerebral ischemia, [RefSeq, PubMed]; GPR17 plays a role in ischemia-induced endogenous repair of immature neonatal cerebral White matter., [RefSeq, PubMed]; GPR17, a Gi-coupled orphan receptor at intermediate phylogenetic position between P2Y and CysLT receptors, is specifically activated by both families of endogenous ligands., [RefSeq, PubMed]; Gpr17 acts as a neurotrophic regulator for neuronal-like cells and interacts with endogenous uracil derivatives, cysteinyl-leukotrienes, and nerve growth factor in the signalling pathways involved in neuronal survival and differentiation., [RefSeq, PubMed]; Involvement of GPR17 in Neuronal Fibre Outgrowth. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL)., [RefSeq, PubMed]; Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation., [RefSeq, PubMed]; These findings suggested that GPR17 may mediate ischemialike neuronal injury and microglial activation in vitro; however, the protective effects on ischemic neuronal injury might depend upon microglial activation., [RefSeq, PubMed]; Zhenbao pill could inhibit neuronal apoptosis by regulating miR-146a-5p/GPR17 expression, and then promoting the recovery of spinal cord function. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033612 receptor serine/threonine kinase binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0002862 negative regulation of inflammatory response to antigenic stimulus;GO:0048709 oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q09QM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8T3-1", "uniprot_id": [ { "id": "CTP5D_RAT", "url": "https://www.uniprot.org/uniprot/Q0V8T3", "type": "external" } ], "mass": 145919.0, "length": 1305, "protein_name": "Contactin-associated protein like 5-4", "gene_name": "Cntnap5d", "organism": "Rat", "refseq_name": "contactin-associated protein like 5-4 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001041331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041331", "type": "external" } ], "gene_names_uniprotkb": "Cntnap5d; Caspr5-4", "gene_names_refseq": "Caspr5-4; Cntnap5c; Cntnap5d; Cntnap5; RGD1566343", "protein_names_uniprotkb": "Contactin-associated protein like 5-4; Cell recognition molecule Caspr5-4; Cell recognition molecule Caspr5d; Contactin-associated protein-like 5d", "protein_names_refseq": "cell recognition molecule Caspr5-3; cell recognition molecule Caspr5-4; cell recognition molecule Caspr5c; cell recognition molecule Caspr5d; contactin associated protein-like 5; contactin-associated protein like 5-4 isoform 1 precursor; contactin-associated protein like 5-4; contactin-associated protein-like 5d", "tax_id": 10116, "disease": "", "pathway": " (rno:297846)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16845472", "class_list": "", "function": "May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8T3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8T4-1", "uniprot_id": [ { "id": "CTP5C_RAT", "url": "https://www.uniprot.org/uniprot/Q0V8T4", "type": "external" } ], "mass": 145719.0, "length": 1307, "protein_name": "Contactin-associated protein like 5-3", "gene_name": "Cntnap5c", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cntnap5c; Caspr5-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Contactin-associated protein like 5-3; Cell recognition molecule Caspr5-3; Cell recognition molecule Caspr5c; Contactin-associated protein-like 5c", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:301650)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16845472", "class_list": "", "function": "May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0001650 fibrillar center;GO:0005604 basement membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0001895 retina homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8T4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8T6-1", "uniprot_id": [ { "id": "CTP5A_RAT", "url": "https://www.uniprot.org/uniprot/Q0V8T6", "type": "external" } ], "mass": 145530.0, "length": 1305, "protein_name": "Contactin-associated protein like 5-1", "gene_name": "Cntnap5a", "organism": "Rat", "refseq_name": "contactin-associated protein like 5-1 precursor", "refseq_ac": [ { "id": "NP_001041330", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041330", "type": "external" } ], "gene_names_uniprotkb": "Cntnap5a; Caspr5-1", "gene_names_refseq": "Caspr5-1; Cntnap5a; RGD1559812", "protein_names_uniprotkb": "Contactin-associated protein like 5-1; Cell recognition molecule Caspr5-1; Cell recognition molecule Caspr5a; Contactin-associated protein-like 5a", "protein_names_refseq": "cell recognition molecule Caspr5-1; cell recognition molecule Caspr5a; contactin-associated protein like 5-1 precursor; contactin-associated protein like 5-1-like; contactin-associated protein like 5-1; contactin-associated protein-like 5a", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308)", "pathway": " (rno:297832)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16845472", "class_list": "", "function": "May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8T6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VGK3-1", "uniprot_id": [ { "id": "GLCTK_RAT", "url": "https://www.uniprot.org/uniprot/Q0VGK3", "type": "external" } ], "mass": 55187.0, "length": 523, "protein_name": "Glycerate kinase", "gene_name": "Glyctk", "organism": "Rat", "refseq_name": "glycerate kinase", "refseq_ac": [ { "id": "NP_001102919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102919", "type": "external" } ], "gene_names_uniprotkb": "Glyctk", "gene_names_refseq": "Glyctk", "protein_names_uniprotkb": "Glycerate kinase; 2.7.1.31", "protein_names_refseq": "glycerate kinase", "tax_id": 10116, "disease": "D-glyceric aciduria (Disease Ontology:DOID:0111626)", "pathway": " (rno:684314); (R-RNO-70350)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.31", "type": "external" } ], "go_molecular_function": "GO:0008887 glycerate kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006001 fructose catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VGK3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIA1-1", "uniprot_id": [ { "id": "NCLN_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIA1", "type": "external" } ], "mass": 62992.0, "length": 563, "protein_name": "BOS complex subunit NCLN", "gene_name": "Ncln", "organism": "Rat", "refseq_name": "BOS complex subunit NCLN precursor", "refseq_ac": [ { "id": "NP_001014104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014104", "type": "external" } ], "gene_names_uniprotkb": "Ncln", "gene_names_refseq": "Ncln; RGD1309355", "protein_names_uniprotkb": "BOS complex subunit NCLN; Nicalin; Nicastrin-like protein", "protein_names_refseq": "BOS complex subunit NCLN precursor; BOS complex subunit NCLN; nicalin homolog; nicastrin-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:314648)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex;GO:0160064 multi-pass translocon complex", "go_biological_process": "GO:0050821 protein stabilization;GO:0009966 regulation of signal transduction;GO:0043254 regulation of protein-containing complex assembly;GO:0061635 regulation of protein complex stability;GO:0160063 multi-pass transmembrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIA1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AZ61-1", "uniprot_id": [ { "id": "LMBD1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AZ61", "type": "external" } ], "mass": 61018.0, "length": 537, "protein_name": "Lysosomal cobalamin transport escort protein LMBD1", "gene_name": "Lmbrd1", "organism": "Rat", "refseq_name": "lysosomal cobalamin transport escort protein LMBD1", "refseq_ac": [ { "id": "NP_631928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631928", "type": "external" } ], "gene_names_uniprotkb": "Lmbrd1", "gene_names_refseq": "LMBD1; Lmbrd1", "protein_names_uniprotkb": "Lysosomal cobalamin transport escort protein LMBD1; LMBD1; LMBR1 domain-containing protein 1", "protein_names_refseq": "LMBR1 domain-containing protein 1; liver regeneration p-53 related protein; lysosomal cobalamin transport escort protein LMBD1; probable lysosomal cobalamin transporter", "tax_id": 10116, "disease": "methylmalonic aciduria and homocystinuria type cblF (Disease Ontology:DOID:0050717)", "pathway": " (rno:246046)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;24078630", "class_list": "", "function": "LMBD1 plays an imperative role in mediating and regulating the endocytosis of the IR., [RefSeq, PubMed]; Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q8R3Z8", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0035612 AP-2 adaptor complex binding;GO:0031419 cobalamin binding;GO:0032050 clathrin heavy chain binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0072583 clathrin-dependent endocytosis;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007369 gastrulation;GO:0038016 insulin receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AZ61-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Z1-1", "uniprot_id": [ { "id": "LIN54_RAT", "url": "https://www.uniprot.org/uniprot/Q641Z1", "type": "external" } ], "mass": 79261.0, "length": 749, "protein_name": "Protein lin-54 homolog", "gene_name": "Lin54", "organism": "Rat", "refseq_name": "protein lin-54 homolog isoform 1", "refseq_ac": [ { "id": "NP_001094034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094034", "type": "external" } ], "gene_names_uniprotkb": "Lin54", "gene_names_refseq": "Lin54; RGD1311361", "protein_names_uniprotkb": "Protein lin-54 homolog", "protein_names_refseq": "protein lin-54 homolog isoform 1; protein lin-54 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:305171); (R-RNO-1538133)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4FZV6", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0046872 metal ion binding;GO:0001067 transcription regulatory region nucleic acid binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090571 RNA polymerase II transcription repressor complex", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q641Z1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H65-1", "uniprot_id": [ { "id": "N42L2_RAT", "url": "https://www.uniprot.org/uniprot/Q66H65", "type": "external" } ], "mass": 65666.0, "length": 574, "protein_name": "NEDD4-binding protein 2-like 2", "gene_name": "N4bp2l2", "organism": "Rat", "refseq_name": "NEDD4-binding protein 2-like 2 isoform 2", "refseq_ac": [ { "id": "NP_001005533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005533", "type": "external" } ], "gene_names_uniprotkb": "N4bp2l2; Pfaap5", "gene_names_refseq": "N4bp2l2", "protein_names_uniprotkb": "NEDD4-binding protein 2-like 2; Phosphonoformate immuno-associated protein 5 homolog", "protein_names_refseq": "NEDD4-binding protein 2-like 2 isoform 2; phosphonoformate immuno-associated protein 5 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:288416)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0017053 transcription repressor complex", "go_biological_process": "GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:1902035 positive regulation of hematopoietic stem cell proliferation;GO:0001824 blastocyst development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66H65-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJV9-1", "uniprot_id": [ { "id": "NTAQ1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJV9", "type": "external" } ], "mass": 24125.0, "length": 207, "protein_name": "Protein N-terminal glutamine amidohydrolase", "gene_name": "Ntaq1", "organism": "Rat", "refseq_name": "protein N-terminal glutamine amidohydrolase", "refseq_ac": [ { "id": "NP_001020195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020195", "type": "external" } ], "gene_names_uniprotkb": "Ntaq1; Wdyhv1", "gene_names_refseq": "Ntaq1; RGD1311362; Wdyhv1", "protein_names_uniprotkb": "Protein N-terminal glutamine amidohydrolase; 3.5.1.122; N-terminal Gln amidase; Nt(Q)-amidase; Protein NH2-terminal glutamine deamidase; WDYHV motif-containing protein 1", "protein_names_refseq": "N-terminal Gln amidase; WDYHV motif containing 1; WDYHV motif-containing protein 1; nt(Q)-amidase; protein N-terminal glutamine amidohydrolase; protein NH2-terminal glutamine deamidase", "tax_id": 10116, "disease": "", "pathway": " (rno:362914)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.122", "type": "external" } ], "go_molecular_function": "GO:0008418 protein-N-terminal asparagine amidohydrolase activity;GO:0070773 protein-N-terminal glutamine amidohydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0036211 protein modification process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJV9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80VL0-1", "uniprot_id": [ { "id": "ICEF1_RAT", "url": "https://www.uniprot.org/uniprot/Q80VL0", "type": "external" } ], "mass": 45686.0, "length": 406, "protein_name": "Interactor protein for cytohesin exchange factors 1", "gene_name": "Ipcef1", "organism": "Rat", "refseq_name": "interactor protein for cytohesin exchange factors 1", "refseq_ac": [ { "id": "NP_001402880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001402880", "type": "external" } ], "gene_names_uniprotkb": "Ipcef1", "gene_names_refseq": "Ipcef1", "protein_names_uniprotkb": "Interactor protein for cytohesin exchange factors 1", "protein_names_refseq": "interactor protein for cytohesin exchange factors 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361474)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12920129;16413275;19756519", "class_list": "", "function": "Correlation of IPCEF1 mRNA expression with nerve injury input in injured dorsal root ganglion suggests that IPCEF1 might participate in the mechanisms that underlie nerve injury-induced membrane receptor trafficking, [RefSeq, PubMed]; Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner., [UniProtKB]; IPCEF1 increases the in vitro and in vivo stimulation of ARFGTP formation by cytohesin 2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007167 enzyme-linked receptor protein signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q80VL0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVH2-1", "uniprot_id": [ { "id": "PLD3_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVH2", "type": "external" } ], "mass": 54399.0, "length": 488, "protein_name": "5'-3' exonuclease PLD3", "gene_name": "Pld3", "organism": "Rat", "refseq_name": "5'-3' exonuclease PLD3", "refseq_ac": [ { "id": "NP_001012167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012167", "type": "external" } ], "gene_names_uniprotkb": "Pld3", "gene_names_refseq": "Pld3", "protein_names_uniprotkb": "5'-3' exonuclease PLD3; (S,S)-bis(monoacylglycero)phosphate synthase PLD3; 2.3.1.-; 3.1.16.1; Phospholipase D3", "protein_names_refseq": "(S,S)-bis(monoacylglycero)phosphate synthase PLD3; 5'-3' exonuclease PLD3; PLD 3; choline phosphatase 3; phosphatidylcholine-hydrolyzing phospholipase D3", "tax_id": 10116, "disease": "spinocerebellar ataxia 46 (Disease Ontology:DOID:0080288)", "pathway": " (rno:361527); (R-RNO-2029485)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10.1039/D0MO00044B;24090084;34106099;38843836", "class_list": "", "function": "Can alternatively catalyze the transfer (transphosphatidylation) of a glycerol group between (S,R)-lysophosphatidylglycerol (LPG) and monoacylglycerol (MAG). The reaction is characterized by an R-to-S stereo-inversion which is essential for the resistance of the produced (S,S)-bis(monoacylglycero)phosphates (BMPs) to lysosomal degradation. The resulting BMPs, are phospholipids required for the formation of lysosomal intralumenal vesicles (ILVs) where lipid degradation can occur., [UniProtKB, UniProtKB]; Lysosomal 5'->3' exonuclease that functions in nucleic-acid sensing by immune cells. Hydrolyzes phosphodiester bond in single-stranded RNA and DNA molecules, with a higher efficiency for molecules with 5' uridine and guanosine residues. It can stall at certain sites and does not necessarily proceed to complete exonucleolytic degradation, thereby producing nucleoside 3'-monophosphates but also 5'-end 5'-hydroxy deoxyribonucleotide/ribonucleotide fragments. Through the processing of self and exogenous RNA and DNA molecules, provides molecular signals to toll-like receptors (TLRs) in innate immunity. Partially redundant with PLD4, it cooperates with the RNase T2/RNASET2 to generate 2',3'-cGMP and cytidine-rich RNA fragments that occupy the two TLR7 ligand-binding pockets, to trigger receptor activation and signaling. Degrades mitochondrial CpG-rich ssDNA fragments to prevent TLR9 activation and autoinflammatory response, but it can cleave viral RNA to generate ligands for TLR7 activation and initiate antiviral immune responses. Can exert polynucleotide phosphatase activity toward 5'-phosphorylated single-stranded DNA substrates although at a slow rate. Regulates the homeostasis and interorganellar communication of the endolysosomal system with an overall impact on cellular removal of dysfunctional organelles via autophagy as well as proper protein and lipid turnover. May play a role in myotube formation in response to ER stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 5, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.16.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.16.1", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006954 inflammatory response;GO:0014902 myotube differentiation;GO:1900015 regulation of cytokine production involved in inflammatory response;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q5FVH2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62959-1", "uniprot_id": [ { "id": "LEPR_RAT", "url": "https://www.uniprot.org/uniprot/Q62959", "type": "external" } ], "mass": 130833.0, "length": 1162, "protein_name": "Leptin receptor", "gene_name": "Lepr", "organism": "Rat", "refseq_name": "leptin receptor isoform 1 precursor", "refseq_ac": [ { "id": "NP_036728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036728", "type": "external" } ], "gene_names_uniprotkb": "Lepr; Fa; Obr", "gene_names_refseq": "Fa; Lepr", "protein_names_uniprotkb": "Leptin receptor; LEP-R; OB receptor; OB-R", "protein_names_refseq": "LEP-R; Leptin receptor (fatty); OB receptor; OB-R; leptin receptor isoform 1 precursor", "tax_id": 10116, "disease": "sleep apnea (Disease Ontology:DOID:0050847); obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); pre-eclampsia (Disease Ontology:DOID:10591); glucose intolerance (Disease Ontology:DOID:10603); short bowel syndrome (Disease Ontology:DOID:10605); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); hyperinsulinism (Disease Ontology:DOID:2018); arteriosclerosis (Disease Ontology:DOID:2349); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); hyperglycemia (Disease Ontology:DOID:4195); pancreatitis (Disease Ontology:DOID:4989); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); proteinuria (Disease Ontology:DOID:576); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diastolic heart failure (Disease Ontology:DOID:9775); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24536)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10698121;11861497;25232147;35198097;35271883;37730735;8630068;8673096;8690163;8702432;8769097;8772180;9268737", "class_list": "", "function": "Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Leptin receptor gene deficiency minimally affects osseointegration in rats. Publication Status: Online-Only, [RefSeq, PubMed]; May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:10698121). Does not induce phosphorylation of and activate STAT3 (By similarity)., [UniProtKB, PubMed, UniProtKB]; May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:8690163). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (By similarity). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; TNF-alpha Antagonizes the Effect of Leptin on Insulin Secretion through FOXO1-Dependent Transcriptional Suppression of LepRb in INS-1 Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility., [RefSeq, PubMed]", "predicted_glycosites": 17, "predicted_n_glycosites": 17, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "O35772;O35773;O54805;P70493;P70494;P70495;P97589;Q62960;Q63007;Q63385;Q63386;Q9ERI4", "ec_number_list": [], "go_molecular_function": "GO:0016500 protein-hormone receptor activity;GO:0042802 identical protein binding;GO:0017046 peptide hormone binding;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0019953 sexual reproduction;GO:1903999 negative regulation of eating behavior;GO:1904060 negative regulation of locomotor rhythm;GO:0001525 angiogenesis;GO:0006091 generation of precursor metabolites and energy", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q62959-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H35-1", "uniprot_id": [ { "id": "LAS2_RAT", "url": "https://www.uniprot.org/uniprot/Q66H35", "type": "external" } ], "mass": 40846.0, "length": 365, "protein_name": "Lung adenoma susceptibility protein 2 homolog", "gene_name": "C18h18orf54; Las2", "organism": "Rat", "refseq_name": "lung adenoma susceptibility protein 2 homolog isoform 2 precursor", "refseq_ac": [ { "id": "NP_001017462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017462", "type": "external" } ], "gene_names_uniprotkb": "C18h18orf54; Las2; LOC361346", "gene_names_refseq": "C18h18orf54; Las2", "protein_names_uniprotkb": "Lung adenoma susceptibility protein 2 homolog", "protein_names_refseq": "lung adenoma susceptibility protein 2 homolog isoform 2 precursor; lung adenoma susceptibility protein 2 homolog; uncharacterized protein C18orf54 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:361346)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Might play a role in cell proliferation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H35-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YDU6-1", "uniprot_id": [ { "id": "NARF_RAT", "url": "https://www.uniprot.org/uniprot/Q2YDU6", "type": "external" } ], "mass": 51466.0, "length": 456, "protein_name": "Nuclear prelamin A recognition factor", "gene_name": "Narf", "organism": "Rat", "refseq_name": "nuclear prelamin A recognition factor", "refseq_ac": [ { "id": "NP_001034296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034296", "type": "external" } ], "gene_names_uniprotkb": "Narf", "gene_names_refseq": "Narf; RGD1310894", "protein_names_uniprotkb": "Nuclear prelamin A recognition factor; IOP2; Iron-only hydrogenase-like protein 2", "protein_names_refseq": "IOP2; iron-only hydrogenase-like protein 2; nuclear prelamin A recognition factor", "tax_id": 10116, "disease": "", "pathway": " (rno:360681)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005521 lamin binding", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005638 lamin filament;GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2YDU6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AZ60-1", "uniprot_id": [ { "id": "EGFL7_RAT", "url": "https://www.uniprot.org/uniprot/Q6AZ60", "type": "external" } ], "mass": 30371.0, "length": 279, "protein_name": "Epidermal growth factor-like protein 7", "gene_name": "Egfl7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Egfl7; Cbl20; Megf7", "gene_names_refseq": "", "protein_names_uniprotkb": "Epidermal growth factor-like protein 7; EGF-like protein 7; Multiple EGF-like domains protein 7; Multiple epidermal growth factor-like domains protein 7", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:245963)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKW3", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005509 calcium ion binding;GO:0005112 Notch binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0007155 cell adhesion;GO:0030336 negative regulation of cell migration;GO:0001568 blood vessel development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AZ60-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M827-1", "uniprot_id": [ { "id": "PIR_RAT", "url": "https://www.uniprot.org/uniprot/Q5M827", "type": "external" } ], "mass": 32179.0, "length": 291, "protein_name": "Pirin", "gene_name": "Pir", "organism": "Rat", "refseq_name": "pirin", "refseq_ac": [ { "id": "NP_001009474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009474", "type": "external" } ], "gene_names_uniprotkb": "Pir", "gene_names_refseq": "Pir", "protein_names_uniprotkb": "Pirin; 1.13.11.24; Probable quercetin 2,3-dioxygenase PIR; Probable quercetinase", "protein_names_refseq": "pirin (iron-binding nuclear protein); pirin; probable quercetin 2,3-dioxygenase PIR; probable quercetinase", "tax_id": 10116, "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)", "pathway": " (rno:363465); (R-RNO-8935690)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.24", "type": "external" } ], "go_molecular_function": "GO:0008127 quercetin 2,3-dioxygenase activity;GO:0046872 metal ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030224 monocyte differentiation;GO:0030099 myeloid cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M827-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0M2-1", "uniprot_id": [ { "id": "NADC_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0M2", "type": "external" } ], "mass": 31297.0, "length": 299, "protein_name": "Nicotinate-nucleotide pyrophosphorylase [carboxylating]", "gene_name": "Qprt", "organism": "Rat", "refseq_name": "nicotinate-nucleotide pyrophosphorylase [carboxylating]", "refseq_ac": [ { "id": "NP_001009646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009646", "type": "external" } ], "gene_names_uniprotkb": "Qprt", "gene_names_refseq": "Qprt", "protein_names_uniprotkb": "Nicotinate-nucleotide pyrophosphorylase [carboxylating]; 2.4.2.19; QAPRTase; QPRTase; Quinolinate phosphoribosyltransferase [decarboxylating]", "protein_names_refseq": "QAPRTase; QPRTase; nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate-nucleotide pyrophosphorylase", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858); pellagra (Disease Ontology:DOID:8457)", "pathway": " (rno:293504); (R-RNO-196807)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the catabolism of quinolinic acid (QA)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.19", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1902494 catalytic complex", "go_biological_process": "GO:0009435 NAD+ biosynthetic process;GO:0034213 quinolinate catabolic process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan;GO:0046874 quinolinate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0M2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7T8-1", "uniprot_id": [ { "id": "CEP44_RAT", "url": "https://www.uniprot.org/uniprot/Q3B7T8", "type": "external" } ], "mass": 43266.0, "length": 386, "protein_name": "Centrosomal protein of 44 kDa", "gene_name": "Cep44", "organism": "Rat", "refseq_name": "centrosomal protein of 44 kDa", "refseq_ac": [ { "id": "NP_001032258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032258", "type": "external" } ], "gene_names_uniprotkb": "Cep44", "gene_names_refseq": "Cep44; RGD1308517", "protein_names_uniprotkb": "Centrosomal protein of 44 kDa; Cep44", "protein_names_refseq": "centrosomal protein of 44 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:290722)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005814 centriole;GO:0030496 midbody;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007098 centrosome cycle;GO:0010457 centriole-centriole cohesion;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7T8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q561S0-1", "uniprot_id": [ { "id": "NDUAA_RAT", "url": "https://www.uniprot.org/uniprot/Q561S0", "type": "external" } ], "mass": 40493.0, "length": 355, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial", "gene_name": "Ndufa10l1; Ndufa10", "organism": "Rat", "refseq_name": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like", "refseq_ac": [ { "id": "NP_872612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_872612", "type": "external" } ], "gene_names_uniprotkb": "Ndufa10l1; Ndufa10; Ndufa10l1", "gene_names_refseq": "CI-42kD; Ndufa10l1; Ndufa10", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; CI-42kD; Complex I-42kD; NADH-ubiquinone oxidoreductase 42 kDa subunit", "protein_names_refseq": "Complex I-42kD; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like; NADH dehydrogenase 1 alpha subcomplex 10-like protein; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; NADH-ubiquinone oxidoreductase 42 kDa subunit", "tax_id": 10116, "disease": "nuclear type mitochondrial complex I deficiency 22 (Disease Ontology:DOID:0112069)", "pathway": " (rno:316632); (rno:678759); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "20966424;26446791;27213235;34502162", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80WE0", "ec_number_list": [], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q561S0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AZ28-1", "uniprot_id": [ { "id": "PIAS2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AZ28", "type": "external" } ], "mass": 63431.0, "length": 572, "protein_name": "E3 SUMO-protein ligase PIAS2", "gene_name": "Pias2", "organism": "Rat", "refseq_name": "E3 SUMO-protein ligase PIAS2 isoform 2", "refseq_ac": [ { "id": "NP_445789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445789", "type": "external" } ], "gene_names_uniprotkb": "Pias2; Miz1; Piasx", "gene_names_refseq": "ARIP3; DIP; Miz1; Pias2; PiasX", "protein_names_uniprotkb": "E3 SUMO-protein ligase PIAS2; 2.3.2.-; ARIP3; Androgen receptor-interacting protein 3; DAB2-interacting protein; DIP; E3 SUMO-protein transferase PIAS2; Msx-interacting-zinc finger protein; Protein inhibitor of activated STAT x; Protein inhibitor of activated STAT2", "protein_names_refseq": "DAB2-interacting protein; E3 SUMO-protein ligase PIAS2 isoform 2; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein transferase PIAS2; androgen receptor-interacting protein 3; msx-interacting-zinc finger protein; protein inhibitor of activated STAT x", "tax_id": 10116, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (rno:83422); (R-RNO-3108214); (R-RNO-3232118); (R-RNO-3232142); (R-RNO-3899300); (R-RNO-4090294); (R-RNO-4551638)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "11117529;11893729;12077349;12855578;26175529;26581215;34947973;9920921", "class_list": "", "function": "Decreasing MIZ1 expression was closely correlated with inflammatory response, and development of acute necrotizing pancreatitis., [RefSeq, PubMed]; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity (By similarity). Sumoylates PML at'Lys-65' and 'Lys-160' (By similarity)., [UniProtKB]; Functions for ZBTB17 in the heart, a transcription factor that may play a role as a novel cardiomyopathy gene, [RefSeq, PubMed]; Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and PIASxalpha. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z177", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" } ], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0016925 protein sumoylation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6AZ28-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7L1-1", "uniprot_id": [ { "id": "PKHH3_RAT", "url": "https://www.uniprot.org/uniprot/Q3B7L1", "type": "external" } ], "mass": 85169.0, "length": 791, "protein_name": "Pleckstrin homology domain-containing family H member 3", "gene_name": "Plekhh3", "organism": "Rat", "refseq_name": "pleckstrin homology domain-containing family H member 3 precursor", "refseq_ac": [ { "id": "NP_001032279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032279", "type": "external" } ], "gene_names_uniprotkb": "Plekhh3", "gene_names_refseq": "Plekhh3; RGD1304854", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family H member 3; PH domain-containing family H member 3", "protein_names_refseq": "PH domain-containing family H member 3; pleckstrin homology domain containing, family H (with MyTH4 domain) member 3; pleckstrin homology domain-containing family H member 3 precursor; pleckstrin homology domain-containing family H member 3", "tax_id": 10116, "disease": "", "pathway": " (rno:360634)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7L1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U367-1", "uniprot_id": [ { "id": "PLOD3_RAT", "url": "https://www.uniprot.org/uniprot/Q5U367", "type": "external" } ], "mass": 85060.0, "length": 741, "protein_name": "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "gene_name": "Plod3", "organism": "Rat", "refseq_name": "multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor", "refseq_ac": [ { "id": "NP_835202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835202", "type": "external" } ], "gene_names_uniprotkb": "Plod3", "gene_names_refseq": "Plod3", "protein_names_uniprotkb": "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; Galactosylhydroxylysine-glucosyltransferase; LH3; Lysyl hydroxylase 3; Procollagen galactosyltransferase; Procollagen glucosyltransferase", "protein_names_refseq": "LH3; bone protein I (BP-I); lysyl hydroxylase 3; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "tax_id": 10116, "disease": "BCARD syndrome (Disease Ontology:DOID:0061197); hypothyroidism (Disease Ontology:DOID:1459); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:288583); (R-RNO-1650814)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "12878181;29393594", "class_list": "glycogene;glycosyltransferase", "function": "Multifunctional enzyme that catalyzes a series of post-translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the ADIPOQ collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV collagens. Essential for normal formation of basement membranes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q811A5", "ec_number_list": [ { "id": "2.4.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.50", "type": "external" }, { "id": "1.14.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.4", "type": "external" }, { "id": "2.4.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.66", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0046872 metal ion binding;GO:0031418 L-ascorbic acid binding;GO:0036094 small molecule binding;GO:0008475 procollagen-lysine 5-dioxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005791 rough endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0042311 vasodilation;GO:0030199 collagen fibril organization;GO:0032870 cellular response to hormone stimulus;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U367-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Y1S1-1", "uniprot_id": [ { "id": "MYD88_RAT", "url": "https://www.uniprot.org/uniprot/Q6Y1S1", "type": "external" } ], "mass": 33856.0, "length": 296, "protein_name": "Myeloid differentiation primary response protein MyD88", "gene_name": "Myd88", "organism": "Rat", "refseq_name": "myeloid differentiation primary response protein MyD88", "refseq_ac": [ { "id": "NP_937763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937763", "type": "external" } ], "gene_names_uniprotkb": "Myd88", "gene_names_refseq": "Myd88", "protein_names_uniprotkb": "Myeloid differentiation primary response protein MyD88", "protein_names_refseq": "myeloid differentiation primary response 88; myeloid differentiation primary response gene 88; myeloid differentiation primary response protein MyD88", "tax_id": 10116, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); lymphoplasmacytic lymphoma (Disease Ontology:DOID:0060901); colorectal carcinoma (Disease Ontology:DOID:0080199); Coronavirus infectious disease (Disease Ontology:DOID:0080599); anogenital venereal wart (Disease Ontology:DOID:11168); testicular lymphoma (Disease Ontology:DOID:12253); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); hepatitis B (Disease Ontology:DOID:2043); colon adenocarcinoma (Disease Ontology:DOID:234); central nervous system lymphoma (Disease Ontology:DOID:3234); lung non-small cell carcinoma (Disease Ontology:DOID:3908); esophageal cancer (Disease Ontology:DOID:5041); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); monoclonal gammopathy of uncertain significance (Disease Ontology:DOID:7442); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:301059); (R-RNO-1257604); (R-RNO-1810476); (R-RNO-209543); (R-RNO-3134963); (R-RNO-6811558); (R-RNO-9020702)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "29393594;34369678;34719837;35959879;37401890;38291253", "class_list": "", "function": "A novel long noncoding RNA-lncRNA-AABR07066529.3 alleviates inflammation, apoptosis, and pyroptosis by inhibiting MyD88 in lipopolysaccharide-induced myocardial depression., [RefSeq, PubMed]; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation (By similarity). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibition of boldenone-induced aggression in rats by curcumin: Targeting TLR4/MyD88/TRAF-6/NF-kappaB pathway., [RefSeq, PubMed]; MiR-505-5p alleviates acute rejection of liver transplantation by inhibiting Myd88 and inducing M2 polarizationof Kupffer cells., [RefSeq, PubMed]; Suppression of MALAT1 promotes human synovial mesenchymal stem cells enhance chondrogenic differentiation and prevent osteoarthritis of the knee in a rat model via regulating miR-212-5p/MyD88 axis., [RefSeq, PubMed]; [Effect of transcutaneous auricular vagus nerve stimulation on the expression of TLR4MyD88IL-18 protein in the prefrontal cortex of depression rats]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QRC0", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0035591 signaling adaptor activity;GO:0035325 Toll-like receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0032747 positive regulation of interleukin-23 production;GO:0002283 neutrophil activation involved in immune response;GO:0032740 positive regulation of interleukin-17 production;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6Y1S1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZX7-1", "uniprot_id": [ { "id": "LDAH_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZX7", "type": "external" } ], "mass": 36881.0, "length": 325, "protein_name": "Lipid droplet-associated hydrolase", "gene_name": "Ldah", "organism": "Rat", "refseq_name": "lipid droplet-associated hydrolase", "refseq_ac": [ { "id": "NP_001014097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014097", "type": "external" } ], "gene_names_uniprotkb": "Ldah", "gene_names_refseq": "Ldah; RGD1311648", "protein_names_uniprotkb": "Lipid droplet-associated hydrolase; 3.1.1.13; Lipid droplet-associated serine hydrolase", "protein_names_refseq": "UPF0554 protein C2orf43 homolog; lipid droplet-associated hydrolase; lipid droplet-associated serine hydrolase", "tax_id": 10116, "disease": "", "pathway": " (rno:313949)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable serine lipid hydrolase associated with lipid droplets. Has low cholesterol esterase activity. Appears to lack triglyceride lipase activity. Involved in cholesterol and triglyceride homeostasis; stimulates cellular triglyceride accumulation and cellular cholesterol release. Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores. May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation. Promotes microtubule-dependent lipid droplet fusion. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0042632 cholesterol homeostasis;GO:0019915 lipid storage;GO:0034389 lipid droplet organization;GO:0035356 intracellular triglyceride homeostasis;GO:0160077 lipid droplet fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5HZX7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7A1-1", "uniprot_id": [ { "id": "LARG2_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7A1", "type": "external" } ], "mass": 79309.0, "length": 690, "protein_name": "Xylosyl- and glucuronyltransferase LARGE2", "gene_name": "Large2", "organism": "Rat", "refseq_name": "xylosyl- and glucuronyltransferase LARGE2", "refseq_ac": [ { "id": "NP_954538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954538", "type": "external" } ], "gene_names_uniprotkb": "Large2; Gyltl1b", "gene_names_refseq": "Gyltl1b; Large2", "protein_names_uniprotkb": "Xylosyl- and glucuronyltransferase LARGE2; 2.4.-.-; Glycosyltransferase-like 1B; LARGE xylosyl- and glucuronyltransferase 2", "protein_names_refseq": "glycosyltransferase-like 1B; glycosyltransferase-like protein LARGE2; xylosyl- and glucuronyltransferase LARGE2", "tax_id": 10116, "disease": "", "pathway": " (rno:311202); (R-RNO-9939291)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Supports the maturation of DAG1 more effectively than LARGE1 (By similarity). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0042285 xylosyltransferase activity;GO:0046872 metal ion binding;GO:0002162 dystroglycan binding;GO:0016757 glycosyltransferase activity;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P7A1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63621-1", "uniprot_id": [ { "id": "IL1AP_RAT", "url": "https://www.uniprot.org/uniprot/Q63621", "type": "external" } ], "mass": 65599.0, "length": 570, "protein_name": "Interleukin-1 receptor accessory protein", "gene_name": "Il1rap", "organism": "Rat", "refseq_name": "interleukin-1 receptor accessory protein precursor", "refseq_ac": [ { "id": "NP_037100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037100", "type": "external" } ], "gene_names_uniprotkb": "Il1rap", "gene_names_refseq": "IL-1RAcp; Il1racpb; Il1rap", "protein_names_uniprotkb": "Interleukin-1 receptor accessory protein; 3.2.2.6; IL-1 receptor accessory protein; IL-1RAcP", "protein_names_refseq": "IL-1 receptor accessory protein; interleukin-1 receptor accessory protein precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:25466); (R-RNO-1257604); (R-RNO-388844); (R-RNO-6811558); (R-RNO-9014826); (R-RNO-9014843); (R-RNO-9020702)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "27440742;8964912", "class_list": "", "function": "Activity of Il-1 in parturition is regulated by progesterone via Il1R1/Il1R2/Il-1RAcp pathway., [RefSeq, PubMed]; Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity). Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0002114 interleukin-33 receptor activity;GO:0015026 coreceptor activity;GO:0019966 interleukin-1 binding;GO:0030674 protein-macromolecule adaptor activity;GO:0004908 interleukin-1 receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0045202 synapse", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0070498 interleukin-1-mediated signaling pathway;GO:0006954 inflammatory response;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63621-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY19-1", "uniprot_id": [ { "id": "COQ8B_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY19", "type": "external" } ], "mass": 58905.0, "length": 528, "protein_name": "Atypical kinase COQ8B, mitochondrial", "gene_name": "Coq8b", "organism": "Rat", "refseq_name": "atypical kinase COQ8B, mitochondrial", "refseq_ac": [ { "id": "NP_001012065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012065", "type": "external" } ], "gene_names_uniprotkb": "Coq8b; Adck4", "gene_names_refseq": "Adck4; Coq8b", "protein_names_uniprotkb": "Atypical kinase COQ8B, mitochondrial; 2.7.-.-; AarF domain-containing protein kinase 4; Coenzyme Q protein 8B", "protein_names_refseq": "aarF domain containing kinase 4; aarF domain-containing protein kinase 4; atypical kinase COQ8B, mitochondrial; coenzyme Q protein 8B", "tax_id": 10116, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 4 (Disease Ontology:DOID:0070241); nephrotic syndrome type 9 (Disease Ontology:DOID:0080391); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (rno:308453); (R-RNO-2142789)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "24270420", "class_list": "", "function": "Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3 (By similarity). According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity). However, the small molecule kinase activity was not confirmed by another publication. Required for podocyte migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" }, { "id": "1.14.13.253", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.253", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0016740 transferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0021692 cerebellar Purkinje cell layer morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AY19-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q769K2-1", "uniprot_id": [ { "id": "NAPEP_RAT", "url": "https://www.uniprot.org/uniprot/Q769K2", "type": "external" } ], "mass": 45723.0, "length": 396, "protein_name": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D", "gene_name": "Napepld", "organism": "Rat", "refseq_name": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D", "refseq_ac": [ { "id": "NP_955413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955413", "type": "external" } ], "gene_names_uniprotkb": "Napepld", "gene_names_refseq": "NAPE-PLD; Napepld", "protein_names_uniprotkb": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; 3.1.4.54; N-acyl phosphatidylethanolamine phospholipase D; NAPE-PLD; NAPE-hydrolyzing phospholipase D", "protein_names_refseq": "N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; NAPE-hydrolyzing phospholipase D", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); osteoarthritis (Disease Ontology:DOID:8398); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:296757)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14634025;15249196;15992380;16527816;17655883", "class_list": "", "function": "D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:17655883). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our results indicate that PGD(2) stimulatory effect involves both PLD and ERK1/2-MAPK activation, and both pathways operate independently of PC synthesis homeostasis., [RefSeq, PubMed]; These results demonstrated wide distribution of NAPE-PLD in various brain regions and its age-dependent expression, suggesting the central role of this enzyme in the formation of anandamide and other N-acylethanolamines in the brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 19, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.54", "type": "external" } ], "go_molecular_function": "GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004620 phospholipase activity;GO:0032052 bile acid binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0070291 N-acylethanolamine metabolic process;GO:1903999 negative regulation of eating behavior;GO:0001659 temperature homeostasis;GO:0035900 response to isolation stress;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q769K2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM33-1", "uniprot_id": [ { "id": "PLEK_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM33", "type": "external" } ], "mass": 39996.0, "length": 350, "protein_name": "Pleckstrin", "gene_name": "Plek", "organism": "Rat", "refseq_name": "pleckstrin", "refseq_ac": [ { "id": "NP_001020921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020921", "type": "external" } ], "gene_names_uniprotkb": "Plek", "gene_names_refseq": "Plek", "protein_names_uniprotkb": "Pleckstrin", "protein_names_refseq": "pleckstrin", "tax_id": 10116, "disease": "", "pathway": " (rno:364206); (R-RNO-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10995449;22673903", "class_list": "", "function": "Major protein kinase C substrate of platelets., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0005080 protein kinase C binding;GO:0019211 phosphatase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032587 ruffle membrane", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0002576 platelet degranulation;GO:0007229 integrin-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KM33-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2P6-1", "uniprot_id": [ { "id": "PIANP_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2P6", "type": "external" } ], "mass": 29132.0, "length": 272, "protein_name": "PILR alpha-associated neural protein", "gene_name": "Pianp", "organism": "Rat", "refseq_name": "PILR alpha-associated neural protein precursor", "refseq_ac": [ { "id": "NP_001014081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014081", "type": "external" } ], "gene_names_uniprotkb": "Pianp; Panp", "gene_names_refseq": "PANP; Pianp; RGD1304952; leda-1", "protein_names_uniprotkb": "PILR alpha-associated neural protein; PILR-associating neural protein; Paired immunoglobin-like type 2 receptor-associating neural protein", "protein_names_refseq": "PILR alpha-associated neural protein precursor; PILR-associating neural protein; liver endothelial differentiation-associated protein-1; paired immunoglobin-like type 2 receptor-associating neural protein; uncharacterized protein C12orf53 homolog", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:312711); (R-RNO-198933)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a ligand for PILRA in neuronal tissues, where it may be involved in immune regulation., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0008542 visual learning;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:0050776 regulation of immune response;GO:0035176 social behavior;GO:0006950 response to stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2P6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RFY2-1", "uniprot_id": [ { "id": "PHAR3_RAT", "url": "https://www.uniprot.org/uniprot/Q6RFY2", "type": "external" } ], "mass": 58461.0, "length": 517, "protein_name": "Phosphatase and actin regulator 3", "gene_name": "Phactr3", "organism": "Rat", "refseq_name": "phosphatase and actin regulator 3 isoform 3", "refseq_ac": [ { "id": "NP_999624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999624", "type": "external" } ], "gene_names_uniprotkb": "Phactr3", "gene_names_refseq": "Phactr3; Scapin1; scapinin", "protein_names_uniprotkb": "Phosphatase and actin regulator 3; Scaffold-associated PP1-inhibiting protein; Scapinin", "protein_names_refseq": "phosphatase and actin regulator 3 isoform 3; scaffold-associated PP1-inhibiting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:362284)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15107502;21487013;22673903;32423795", "class_list": "", "function": "Because its expression is highest in relatively plastic regions of the adult brain (cortex, hippocampus), scapinin is a new regulator of neurite outgrowth and neuroplasticity in the brain., [RefSeq, PubMed]; Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016363 nuclear matrix", "go_biological_process": "GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6RFY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXZ3-1", "uniprot_id": [ { "id": "P2R3C_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXZ3", "type": "external" } ], "mass": 53379.0, "length": 453, "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "gene_name": "Ppp2r3c", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "refseq_ac": [ { "id": "NP_001014218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014218", "type": "external" } ], "gene_names_uniprotkb": "Ppp2r3c", "gene_names_refseq": "Ppp2r3c; RGD1309207", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "protein_names_refseq": "serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma-like; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma", "tax_id": 10116, "disease": "spermatogenic failure 36 (Disease Ontology:DOID:0111921)", "pathway": " (rno:362739)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0005634 nucleus", "go_biological_process": "GO:0002759 regulation of antimicrobial humoral response;GO:0051900 regulation of mitochondrial depolarization;GO:0035303 regulation of dephosphorylation;GO:0032147 activation of protein kinase activity;GO:0048536 spleen development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXZ3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W90-1", "uniprot_id": [ { "id": "LHX9_RAT", "url": "https://www.uniprot.org/uniprot/Q80W90", "type": "external" } ], "mass": 42934.0, "length": 388, "protein_name": "LIM/homeobox protein Lhx9", "gene_name": "Lhx9", "organism": "Rat", "refseq_name": "LIM/homeobox protein Lhx9", "refseq_ac": [ { "id": "NP_852032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852032", "type": "external" } ], "gene_names_uniprotkb": "Lhx9", "gene_names_refseq": "Lhx9", "protein_names_uniprotkb": "LIM/homeobox protein Lhx9; LIM homeobox protein 9", "protein_names_refseq": "LIM homeobox protein 9; LIM-homeodomain type transcription factor 9; LIM/homeobox protein Lhx9", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:289048)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12617828;15585134", "class_list": "", "function": "Involved in gonadal development., [UniProtKB]; Lhx9 and Lhx9alpha isoforms could be implicated in regulating various aspects of neuronal differentiation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A5M2;Q811Z4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008283 cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription;GO:0008584 male gonad development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80W90-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIH7-1", "uniprot_id": [ { "id": "PHB2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIH7", "type": "external" } ], "mass": 33312.0, "length": 299, "protein_name": "Prohibitin-2", "gene_name": "Phb2", "organism": "Rat", "refseq_name": "prohibitin-2", "refseq_ac": [ { "id": "NP_001013053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013053", "type": "external" } ], "gene_names_uniprotkb": "Phb2; Bcap37", "gene_names_refseq": "Bap-37; Bap37; Bap; Bcap27; Bcap37; Phb2", "protein_names_uniprotkb": "Prohibitin-2; B-cell receptor-associated protein BAP37; BAP-37", "protein_names_refseq": "B-cell receptor associated protein 37; B-cell receptor-associated protein BAP37; prohibitin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:114766); (R-RNO-8949664); (R-RNO-9840373)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10559001;11302691;22673903;27213235;29867124;34502162;37046989;37958902;38260951", "class_list": "", "function": "COMP-prohibitin 2 interaction in mitochondria plays an important role in maintaining the contractile phenotype of Vascular smooth muscle cells by regulating mitochondrial oxidative phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the mitochondria, together with PHB1, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6., [UniProtKB, UniProtKB]; In the nucleus, serves as transcriptional co-regulator. Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the plasma membrane, is involved in IGFBP6-induced cell migration (By similarity). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; In the plasma membrane, is involved in IGFBP6-induced cell migration. Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia. Publication Status: Online-Only, [RefSeq, PubMed]; Oxidative stress suppresses PHB2-mediated mitophagy in beta-cells via the Nrf2/PHB2 pathway., [RefSeq, PubMed]; PHB2 Alleviates Neurotoxicity of Prion Peptide PrP[106-126] via PINK1/Parkin-Dependent Mitophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P70629;P70630", "ec_number_list": [], "go_molecular_function": "GO:0033218 amide binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0046625 sphingolipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0060762 regulation of branching involved in mammary gland duct morphogenesis;GO:0006351 DNA-templated transcription;GO:0016477 cell migration;GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5XIH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0D5-1", "uniprot_id": [ { "id": "LHPP_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0D5", "type": "external" } ], "mass": 29190.0, "length": 270, "protein_name": "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "gene_name": "Lhpp", "organism": "Rat", "refseq_name": "phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "refseq_ac": [ { "id": "NP_001009706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009706", "type": "external" } ], "gene_names_uniprotkb": "Lhpp", "gene_names_refseq": "Lhpp", "protein_names_uniprotkb": "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; 3.1.3.-; 3.6.1.1", "protein_names_refseq": "phospholysine phosphohistidine inorganic pyrophosphate phosphatase", "tax_id": 10116, "disease": "", "pathway": " (rno:361663); (R-RNO-71737)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0004427 inorganic diphosphate phosphatase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0D5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63434-1", "uniprot_id": [ { "id": "PLGF_RAT", "url": "https://www.uniprot.org/uniprot/Q63434", "type": "external" } ], "mass": 17681.0, "length": 158, "protein_name": "Placenta growth factor", "gene_name": "Pgf", "organism": "Rat", "refseq_name": "placenta growth factor precursor", "refseq_ac": [ { "id": "NP_446047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446047", "type": "external" } ], "gene_names_uniprotkb": "Pgf; Plgf", "gene_names_refseq": "Pgf; Plgf", "protein_names_uniprotkb": "Placenta growth factor; PlGF", "protein_names_refseq": "placenta growth factor precursor; placenta growth factor", "tax_id": 10116, "disease": "pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); pyelonephritis (Disease Ontology:DOID:11400); limited scleroderma (Disease Ontology:DOID:1577); breast cancer (Disease Ontology:DOID:1612); pancreatic endocrine carcinoma (Disease Ontology:DOID:1798); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); carotid artery disease (Disease Ontology:DOID:3407); renal cell carcinoma (Disease Ontology:DOID:4450); lymphedema (Disease Ontology:DOID:4977); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:94203); (R-RNO-194313); (R-RNO-195399)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "29933759;30361676;33379399;34530740;37424113;7706320", "class_list": "", "function": "Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1-4-8 during the three trimesters of rat pregnancy at the maternal-fetal interface., [RefSeq, PubMed]; Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hyperhomocysteinemia might cause choroidal angiogenesiswith Placental Growth Factor Upregulation. Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA-214 promotes alveolarization in neonatal rat models of bronchopulmonary dysplasia via the PlGF-dependent STAT3 pathway. Erratum:[Mol Med. 2021 Oct 21;27(1):134. doi: 10.1186/s10020-021-00396-y. PMID: 34674634] Publication Status: Online-Only, [RefSeq, PubMed]; Sex Differences in Placental Protein Expression and Efficiency in a Rat Model of Fetal Programming Induced by Maternal Undernutrition. Publication Status: Online-Only, [RefSeq, PubMed]; Studied the influence of dendrobium nobile Lindley (DNL) extract and its bibenzyl component moscatilin on the expression of placental growth factor (PLGF) and Norrie disease protein (NDP) in hypoxia model in retinal cells. Found DNL and moscatilin are able to protect against retinal ischemic/hypoxic changes respectively by downregulating PLGF and upregulating NDP. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0008083 growth factor activity;GO:0005172 vascular endothelial growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0001666 response to hypoxia;GO:0005977 glycogen metabolic process;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63434-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U315-1", "uniprot_id": [ { "id": "GLD2_RAT", "url": "https://www.uniprot.org/uniprot/Q5U315", "type": "external" } ], "mass": 56007.0, "length": 484, "protein_name": "Poly(A) RNA polymerase GLD2", "gene_name": "Tent2", "organism": "Rat", "refseq_name": "poly(A) RNA polymerase GLD2", "refseq_ac": [ { "id": "NP_001008373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008373", "type": "external" } ], "gene_names_uniprotkb": "Tent2; Gld2; Palp4", "gene_names_refseq": "Papd4; Tent2", "protein_names_uniprotkb": "Poly(A) RNA polymerase GLD2; 2.7.7.19; PAP-associated domain-containing protein 4; Terminal nucleotidyltransferase 2", "protein_names_refseq": "PAP associated domain containing 4; PAP-associated domain-containing protein 4; poly(A) RNA polymerase D4, non-canonical; poly(A) RNA polymerase GLD2", "tax_id": 10116, "disease": "", "pathway": " (rno:361878)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22727665;23700402;29393594", "class_list": "", "function": "Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus, [RefSeq, PubMed]; XRN2 and PAPD4 and are highly expressed in the retina and have distinct gene expression profiles during development. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0098794 postsynapse;GO:0140240 perforant pathway to dendrate granule cell synapse", "go_biological_process": "GO:0021766 hippocampus development;GO:0060041 retina development in camera-type eye;GO:0030182 neuron differentiation;GO:0090314 positive regulation of protein targeting to membrane;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5U315-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXY4-1", "uniprot_id": [ { "id": "DPOD2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXY4", "type": "external" } ], "mass": 51346.0, "length": 469, "protein_name": "DNA polymerase delta subunit 2", "gene_name": "Pold2", "organism": "Rat", "refseq_name": "DNA polymerase delta subunit 2", "refseq_ac": [ { "id": "NP_001013068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013068", "type": "external" } ], "gene_names_uniprotkb": "Pold2", "gene_names_refseq": "Pold2", "protein_names_uniprotkb": "DNA polymerase delta subunit 2; DNA polymerase delta subunit p50", "protein_names_refseq": "DAN polymerase delta 2, accessory subunit; DNA polymerase delta subunit 2; DNA polymerase delta subunit p50; DNA-directed DNA polymerase delta 2; polymerase (DNA directed), delta 2, accessory subunit; polymerase (DNA directed), delta 2, regulatory subunit; polymerase (DNA) delta 2, accessory subunit", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:289758); (R-RNO-110314); (R-RNO-174411); (R-RNO-174414); (R-RNO-174417); (R-RNO-174437); (R-RNO-5358565); (R-RNO-5358606); (R-RNO-5651801); (R-RNO-5656169); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-69091); (R-RNO-69166); (R-RNO-69183)", "pathway_count": 19, "publication_count": 1, "publication_id_list": "15982757", "class_list": "", "function": "Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0043625 delta DNA polymerase complex;GO:0005654 nucleoplasm;GO:0016035 zeta DNA polymerase complex", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0042276 error-prone translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXY4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZW7-1", "uniprot_id": [ { "id": "PLET1_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZW7", "type": "external" } ], "mass": 26849.0, "length": 255, "protein_name": "Placenta-expressed transcript 1 protein", "gene_name": "Plet1", "organism": "Rat", "refseq_name": "placenta-expressed transcript 1 protein isoform 1 precursor", "refseq_ac": [ { "id": "NP_001014231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014231", "type": "external" } ], "gene_names_uniprotkb": "Plet1", "gene_names_refseq": "Plet1", "protein_names_uniprotkb": "Placenta-expressed transcript 1 protein", "protein_names_refseq": "placenta-expressed transcript 1 protein isoform 1 precursor; placenta-expressed transcript 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:363060); (R-RNO-163125)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration;GO:0001953 negative regulation of cell-matrix adhesion;GO:0035313 wound healing, spreading of epidermal cells", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5HZW7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80W89-1", "uniprot_id": [ { "id": "NDUAB_RAT", "url": "https://www.uniprot.org/uniprot/Q80W89", "type": "external" } ], "mass": 14854.0, "length": 141, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11", "gene_name": "Ndufa11", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11", "refseq_ac": [ { "id": "NP_997682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997682", "type": "external" } ], "gene_names_uniprotkb": "Ndufa11", "gene_names_refseq": "Ndufa11", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; CI-B14.7; Complex I-B14.7; NADH-ubiquinone oxidoreductase subunit B14.7", "protein_names_refseq": "CI-B14.7; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; NADH-ubiquinone oxidoreductase subunit B14.7; complex I-B14.7", "tax_id": 10116, "disease": "nuclear type mitochondrial complex I deficiency 14 (Disease Ontology:DOID:0112094); communication disorder (Disease Ontology:DOID:2033)", "pathway": " (rno:301123); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80W89-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64194-1", "uniprot_id": [ { "id": "LICH_RAT", "url": "https://www.uniprot.org/uniprot/Q64194", "type": "external" } ], "mass": 45186.0, "length": 397, "protein_name": "Lysosomal acid lipase/cholesteryl ester hydrolase", "gene_name": "Lipa", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lipa; Lal; Lip1", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysosomal acid lipase/cholesteryl ester hydrolase; 3.1.1.13; Acid cholesteryl ester hydrolase; Cholesteryl esterase; Diacylglycerol lipase; LAL; Lipase A; Sterol esterase; Triacylglycerol ester hydrolase; Triacylglycerol lipase", "protein_names_refseq": "", "tax_id": 10116, "disease": "lysosomal acid lipase deficiency (Disease Ontology:DOID:0080217); Wolman disease (Disease Ontology:DOID:14497); cholesterol ester storage disease (Disease Ontology:DOID:14502)", "pathway": " (rno:25055); (R-RNO-8964038)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "4062953;8576647", "class_list": "", "function": "Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. Hydrolyzes triglycerides (1,2,3-triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3-diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0016298 lipase activity;GO:0016788 hydrolase activity, acting on ester bonds", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0006638 neutral lipid metabolic process;GO:1903409 reactive oxygen species biosynthetic process;GO:0000278 mitotic cell cycle;GO:0001523 retinoid metabolic process;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64194-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62795-1", "uniprot_id": [ { "id": "NPT1_RAT", "url": "https://www.uniprot.org/uniprot/Q62795", "type": "external" } ], "mass": 51350.0, "length": 465, "protein_name": "Sodium-dependent phosphate transport protein 1", "gene_name": "Slc17a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc17a1; AABR07027750.1; Npt1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 1; Na(+)/PI cotransporter 1; Renal Na(+)-dependent phosphate cotransporter 1; Renal sodium-dependent phosphate transport protein 1; Renal sodium-phosphate transport protein 1; Sodium/phosphate cotransporter 1; Solute carrier family 17 member 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171080); (R-RNO-427652)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8867793", "class_list": "", "function": "Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity;GO:0015293 symporter activity;GO:0005315 phosphate transmembrane transporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0046415 urate metabolic process;GO:0035435 phosphate ion transmembrane transport;GO:0015747 urate transport;GO:0044341 sodium-dependent phosphate transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62795-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q792H5-1", "uniprot_id": [ { "id": "CELF2_RAT", "url": "https://www.uniprot.org/uniprot/Q792H5", "type": "external" } ], "mass": 54271.0, "length": 508, "protein_name": "CUGBP Elav-like family member 2", "gene_name": "Celf2", "organism": "Rat", "refseq_name": "CUGBP Elav-like family member 2 isoform 1", "refseq_ac": [ { "id": "NP_058893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058893", "type": "external" } ], "gene_names_uniprotkb": "Celf2; Cugbp2; Etr3; Napor", "gene_names_refseq": "Brunol3; Celf2; Cugbp2; Etr3; Napor", "protein_names_uniprotkb": "CUGBP Elav-like family member 2; Bruno-like protein 3; CELF-2; CUG triplet repeat RNA-binding protein 2; CUG-BP- and ETR-3-like factor 2; CUG-BP2; ELAV-type RNA-binding protein 3; ETR-3; Neuroblastoma apoptosis-related RNA-binding protein; Protein ETR-R3; RNA-binding protein BRUNOL-3; rNapor", "protein_names_refseq": "CUG triplet repeat, RNA binding protein 2; CUG-BP- and ETR-3-like factor 2; CUGBP Elav-like family member 2 isoform 1; Cugbp- and Etr3-like factor 2; RNA-binding protein BRUNOL-3; RNA-binding protein Brunol3; bruno-like protein 3; elav-type RNA-binding protein 3; neuroblastoma apoptosis-related RNA-binding protein", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 97 (Disease Ontology:DOID:0070383)", "pathway": " (rno:29428)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10524244;11850193;12022233;12535526;23661609;26166732", "class_list": "", "function": "A regulatory connection between COX-2 and CUGBP2 in the cardiac cells, was demonstrated., [RefSeq, PubMed]; Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain, [RefSeq, PubMed]; RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Promotes inclusion of exon 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA (By similarity). Involved in the apoB RNA editing activity (By similarity). Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine (By similarity). Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These findings identify a novel paradigm for RNA binding proteins such as CUGBP2 in facilitating opposing functions of mRNA stability and translation inhibition and reveal a mechanism for inhibiting cyclooxygenase-2 expression in cancer cells., [RefSeq, PubMed]; This study demonstrated that Cugbp2 regulates splicing and translation of mRNAs linked to sexual differentiation in rats., [RefSeq, PubMed]; Tissue-specific distribution of NAPOR, CUG-BP, and other highly related proteins within the nervous system, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L1J5;O88756;Q78ZF0", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006376 mRNA splice site recognition;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0016441 post-transcriptional gene silencing;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q792H5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIR6-1", "uniprot_id": [ { "id": "DRC10_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIR6", "type": "external" } ], "mass": 53256.0, "length": 457, "protein_name": "Dynein regulatory complex subunit 10", "gene_name": "Ddx54; Drc10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ddx54; Drc10; Ddx54; Drc10; Iqcd", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein regulatory complex subunit 10; IQ domain-containing protein D", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:498184)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0036064 ciliary basal body;GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006396 RNA processing;GO:0016070 RNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIR6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI54-1", "uniprot_id": [ { "id": "DRC3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI54", "type": "external" } ], "mass": 60798.0, "length": 523, "protein_name": "Dynein regulatory complex subunit 3", "gene_name": "Drc3", "organism": "Rat", "refseq_name": "dynein regulatory complex subunit 3", "refseq_ac": [ { "id": "NP_001013879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013879", "type": "external" } ], "gene_names_uniprotkb": "Drc3; Lrrc48", "gene_names_refseq": "Drc3; Lrrc48; RGD1309150", "protein_names_uniprotkb": "Dynein regulatory complex subunit 3; Leucine-rich repeat-containing protein 48", "protein_names_refseq": "dynein regulatory complex subunit 3; leucine rich repeat containing 48; leucine-rich repeat-containing protein 48", "tax_id": 10116, "disease": "", "pathway": " (rno:287371)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, 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cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097545 axonemal doublet microtubule", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI54-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQQ5-1", "uniprot_id": [ { "id": "LETM2_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQQ5", "type": "external" } ], "mass": 52524.0, "length": 459, "protein_name": "LETM1 domain-containing protein LETM2, mitochondrial", "gene_name": "Letm2", "organism": "Rat", "refseq_name": "LETM1 domain-containing protein LETM2, mitochondrial isoform 1 precursor", "refseq_ac": [ { "id": "NP_001012158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012158", "type": "external" } ], "gene_names_uniprotkb": "Letm2", "gene_names_refseq": "LETM2S; Letm2", "protein_names_uniprotkb": "LETM1 domain-containing protein LETM2, mitochondrial; LETM1 and EF-hand domain-containing protein 2; Leucine zipper-EF-hand-containing transmembrane protein 1-like", "protein_names_refseq": "LETM1 and EF-hand domain-containing protein 2; LETM1 domain-containing protein LETM2, mitochondrial isoform 1 precursor; LETM1 domain-containing protein LETM2, mitochondrial; leucine zipper-, EF-hand motif- containing transmembrane protein 2S; leucine zipper-, EF-hand motif- containing transmembrane protein 2; leucine zipper-EF-hand containing transmembrane protein 2", "tax_id": 10116, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460)", "pathway": " (rno:361169)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18628306", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7VL16", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0006851 mitochondrial calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQQ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M834-1", "uniprot_id": [ { "id": "DTBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M834", "type": "external" } ], "mass": 39742.0, "length": 352, "protein_name": "Dysbindin", "gene_name": "Dtnbp1", "organism": "Rat", "refseq_name": "dysbindin", "refseq_ac": [ { "id": "NP_001032753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032753", "type": "external" } ], "gene_names_uniprotkb": "Dtnbp1; Bloc1s8", "gene_names_refseq": "Dtnbp1", "protein_names_uniprotkb": "Dysbindin; BLOC-1 subunit 8; Biogenesis of lysosome-related organelles complex 1 subunit 8; Dysbindin-1; Dystrobrevin-binding protein 1", "protein_names_refseq": "BLOC-1 subunit 8; biogenesis of lysosome-related organelles complex 1 subunit 8; distrobrevin binding protein 1; dysbindin-1; dysbindin", "tax_id": 10116, "disease": "Hermansky-Pudlak syndrome 7 (Disease Ontology:DOID:0060545); platelet storage pool deficiency (Disease Ontology:DOID:2223); temporal lobe epilepsy (Disease Ontology:DOID:3328); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753); schizophrenia (Disease Ontology:DOID:5419); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (rno:641528); (R-RNO-432722)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11316798;16288221;16448387;16760431;17989303;18683930;19010779;19428785", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GX90", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007613 memory;GO:0010628 positive regulation of gene expression;GO:0031175 neuron projection development;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q5M834-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQS5-1", "uniprot_id": [ { "id": "CYYR1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQS5", "type": "external" } ], "mass": 18050.0, "length": 165, "protein_name": "Cysteine and tyrosine-rich protein 1", "gene_name": "Cyyr1", "organism": "Rat", "refseq_name": "cysteine and tyrosine-rich protein 1 precursor", "refseq_ac": [ { "id": "NP_001014002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014002", "type": "external" } ], "gene_names_uniprotkb": "Cyyr1", "gene_names_refseq": "Cyyr1", "protein_names_uniprotkb": "Cysteine and tyrosine-rich protein 1", "protein_names_refseq": "cysteine and tyrosine-rich protein 1 precursor; cysteine and tyrosine-rich protein 1; cysteine/tyrosine-rich 1", "tax_id": 10116, "disease": "", "pathway": " (rno:304138)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQS5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIK8-1", "uniprot_id": [ { "id": "CTSL2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIK8", "type": "external" } ], "mass": 52783.0, "length": 465, "protein_name": "CTD small phosphatase-like protein 2", "gene_name": "Ctdspl2", "organism": "Rat", "refseq_name": "CTD small phosphatase-like protein 2", "refseq_ac": [ { "id": "NP_001014070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014070", "type": "external" } ], "gene_names_uniprotkb": "Ctdspl2; Scp4", "gene_names_refseq": "Ctdspl2; RGD1309219; SCP4", "protein_names_uniprotkb": "CTD small phosphatase-like protein 2; 3.1.3.16; CTDSP-like 2; SCP4; Small C-terminal domain phosphatase 4; Small CTD phosphatase 4", "protein_names_refseq": "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2; CTD small phosphatase-like protein 2; CTDSP-like 2; small C-terminal domain phosphatase 4; small CTD phosphatase 4", "tax_id": 10116, "disease": "", "pathway": " (rno:311368)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Serine/threonine phosphatase that promotes gluconeogenesis by dephosphorylating FOXO1 and FOXO3A, promoting their nuclear retention and enhancing their transcriptional activity on PCK1 and G6PC1, key enzymes in hepatic gluconeogenesis. Essential for proper embryonic skeletal development by regulating chondrocyte survival through dephosphorylation of FOXO3. By maintaining FOXO3 in its active, dephosphorylated form, inhibits excessive apoptosis of chondrocytes, which is essential for normal endochondral ossification and cartilage formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0046827 positive regulation of protein export from nucleus;GO:0030514 negative regulation of BMP signaling pathway;GO:0006470 protein dephosphorylation;GO:0060348 bone development;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499U4-1", "uniprot_id": [ { "id": "DRC4_RAT", "url": "https://www.uniprot.org/uniprot/Q499U4", "type": "external" } ], "mass": 56313.0, "length": 478, "protein_name": "Dynein regulatory complex subunit 4", "gene_name": "Drc4", "organism": "Rat", "refseq_name": "dynein regulatory complex subunit 4", "refseq_ac": [ { "id": "NP_001034119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034119", "type": "external" } ], "gene_names_uniprotkb": "Drc4; Gas11; Gas8", "gene_names_refseq": "Drc4; Gas8", "protein_names_uniprotkb": "Dynein regulatory complex subunit 4; GAS-11; GAS-8; Growth arrest-specific protein 11; Growth arrest-specific protein 8", "protein_names_refseq": "GAS-11; GAS-8; dynein regulatory complex subunit 4; growth arrest specific 8; growth arrest-specific protein 11; growth arrest-specific protein 8", "tax_id": 10116, "disease": "primary ciliary dyskinesia 33 (Disease Ontology:DOID:0110619)", "pathway": " (rno:361438)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005874 microtubule", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0060294 cilium movement involved in cell motility;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499U4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63170-1", "uniprot_id": [ { "id": "DYH7_RAT", "url": "https://www.uniprot.org/uniprot/Q63170", "type": "external" } ], "mass": 464557.0, "length": 4057, "protein_name": "Dynein axonemal heavy chain 7", "gene_name": "Dnah7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dnah7; Axob; Dlp7", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal heavy chain 7; Axonemal beta dynein heavy chain 7; Axonemal dynein heavy chain b; Ciliary dynein heavy chain 7; Dynein-like protein 7", "protein_names_refseq": "", "tax_id": 10116, "disease": "primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:252893)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "29393594;7657712;8741840", "class_list": "", "function": "Force generating protein that probably plays an important role in respiratory cilia and sperm flagella beating (By similarity). Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q62821", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0097227 sperm annulus;GO:0005874 microtubule;GO:0005929 cilium;GO:0097225 sperm midpiece;GO:0036156 inner dynein arm", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0003341 cilium movement;GO:0036159 inner dynein arm assembly;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63170-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7U9-1", "uniprot_id": [ { "id": "FKBP8_RAT", "url": "https://www.uniprot.org/uniprot/Q3B7U9", "type": "external" } ], "mass": 43556.0, "length": 403, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP8", "gene_name": "Fkbp8", "organism": "Rat", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP8", "refseq_ac": [ { "id": "NP_001032257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032257", "type": "external" } ], "gene_names_uniprotkb": "Fkbp8", "gene_names_refseq": "FKBP-8; Fkbp8", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP8; 5.2.1.8; FK506-binding protein 8; FKBP-8; PPIase FKBP8; Rotamase", "protein_names_refseq": "FK506 binding protein 8, 38kDa; FK506-binding protein 8; PPIase FKBP8; peptidyl-prolyl cis-trans isomerase FKBP8; rotamase", "tax_id": 10116, "disease": "spina bifida (Disease Ontology:DOID:0080016); clubfoot (Disease Ontology:DOID:11836)", "pathway": " (rno:290652); (R-RNO-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0097718 disordered domain specific binding;GO:0044183 protein folding chaperone;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005829 cytosol;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0001708 cell fate specification;GO:0070585 protein localization to mitochondrion;GO:0043066 negative regulation of apoptotic process;GO:0001933 negative regulation of protein phosphorylation;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7U9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63150-1", "uniprot_id": [ { "id": "DPYS_RAT", "url": "https://www.uniprot.org/uniprot/Q63150", "type": "external" } ], "mass": 56815.0, "length": 519, "protein_name": "Dihydropyrimidinase", "gene_name": "Dpys", "organism": "Rat", "refseq_name": "dihydropyrimidinase", "refseq_ac": [ { "id": "NP_113893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113893", "type": "external" } ], "gene_names_uniprotkb": "Dpys", "gene_names_refseq": "DHP; Dpys", "protein_names_uniprotkb": "Dihydropyrimidinase; 3.5.2.2; DHPase; DHP; Dihydropyrimidine amidohydrolase; Hydantoinase", "protein_names_refseq": "DHPase; dihydropyrimidinase; dihydropyrimidine amidohydrolase; hydantoinase", "tax_id": 10116, "disease": "dihydropyrimidinase deficiency (Disease Ontology:DOID:0111629); purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)", "pathway": " (rno:65135); (R-RNO-73621)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8679696", "class_list": "", "function": "Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q642F0", "ec_number_list": [ { "id": "3.5.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.2", "type": "external" } ], "go_molecular_function": "GO:0002058 uracil binding;GO:0002059 thymine binding;GO:0004157 dihydropyrimidinase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046079 dUMP catabolic process;GO:0006208 pyrimidine nucleobase catabolic process;GO:0006210 thymine catabolic process;GO:0006212 uracil catabolic process;GO:0019860 uracil metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63150-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI65-1", "uniprot_id": [ { "id": "DRC1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI65", "type": "external" } ], "mass": 88310.0, "length": 754, "protein_name": "Dynein regulatory complex protein 1", "gene_name": "Drc1", "organism": "Rat", "refseq_name": "dynein regulatory complex protein 1", "refseq_ac": [ { "id": "NP_001007010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007010", "type": "external" } ], "gene_names_uniprotkb": "Drc1; Ccdc164", "gene_names_refseq": "Ccdc164; Drc1", "protein_names_uniprotkb": "Dynein regulatory complex protein 1; Coiled-coil domain-containing protein 164", "protein_names_refseq": "coiled-coil domain containing 164; coiled-coil domain-containing protein 164; dynein regulatory complex protein 1; dynein regulatory complex subunit 1 homolog", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); spermatogenic failure 80 (Disease Ontology:DOID:0070579); primary ciliary dyskinesia 21 (Disease Ontology:DOID:0110596)", "pathway": " (rno:362712)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0005858 axonemal dynein complex", "go_biological_process": "GO:0007507 heart development;GO:0007338 single fertilization;GO:0007368 determination of left/right symmetry;GO:0035082 axoneme assembly;GO:0044782 cilium organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI65-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q642A5-1", "uniprot_id": [ { "id": "DPOE3_RAT", "url": "https://www.uniprot.org/uniprot/Q642A5", "type": "external" } ], "mass": 16674.0, "length": 145, "protein_name": "DNA polymerase epsilon subunit 3", "gene_name": "Pole3", "organism": "Rat", "refseq_name": "DNA polymerase epsilon subunit 3", "refseq_ac": [ { "id": "NP_001007653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007653", "type": "external" } ], "gene_names_uniprotkb": "Pole3", "gene_names_refseq": "Pole3", "protein_names_uniprotkb": "DNA polymerase epsilon subunit 3; DNA polymerase II subunit 3; DNA polymerase epsilon subunit p17", "protein_names_refseq": "DNA polymerase II subunit 3; DNA polymerase epsilon subunit 3; DNA polymerase epsilon subunit p17; DNA-directed DNA polymerase epsilon 3; polymerase (DNA directed), epsilon 3 (p17 subunit); polymerase (DNA directed), epsilon 3, accessory subunit; polymerase (DNA) epsilon 3, accessory subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:298098); (R-RNO-110314); (R-RNO-5651801); (R-RNO-5656169); (R-RNO-5685942); (R-RNO-5693537); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-68952); (R-RNO-68962)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031490 chromatin DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0008622 epsilon DNA polymerase complex;GO:0005721 pericentric heterochromatin;GO:0008623 CHRAC;GO:0140672 ATAC complex;GO:0005634 nucleus", "go_biological_process": "GO:0006272 leading strand elongation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006974 DNA damage response;GO:0006275 regulation of DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q642A5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKI3-1", "uniprot_id": [ { "id": "DPOLL_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKI3", "type": "external" } ], "mass": 62401.0, "length": 573, "protein_name": "DNA polymerase lambda", "gene_name": "Poll", "organism": "Rat", "refseq_name": "DNA polymerase lambda", "refseq_ac": [ { "id": "NP_001014190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014190", "type": "external" } ], "gene_names_uniprotkb": "Poll", "gene_names_refseq": "Poll", "protein_names_uniprotkb": "DNA polymerase lambda; 2.7.7.7; 4.2.99.-; Pol Lambda", "protein_names_refseq": "DNA polymerase lambda; DNA-directed DNA polymerase lambda; pol Lambda; polymerase (DNA directed), lambda; polymerase (DNA) lambda", "tax_id": 10116, "disease": "", "pathway": " (rno:361767); (R-RNO-5693571)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0016829 lyase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006287 base-excision repair, gap-filling;GO:0006260 DNA replication;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RKI3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62952-1", "uniprot_id": [ { "id": "DPYL3_RAT", "url": "https://www.uniprot.org/uniprot/Q62952", "type": "external" } ], "mass": 61967.0, "length": 570, "protein_name": "Dihydropyrimidinase-related protein 3", "gene_name": "Dpysl3", "organism": "Rat", "refseq_name": "dihydropyrimidinase-related protein 3 isoform 1", "refseq_ac": [ { "id": "NP_037066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037066", "type": "external" } ], "gene_names_uniprotkb": "Dpysl3; Crmp4", "gene_names_refseq": "Crmp4; Dpysl3; TUC-4b", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 3; CRMP-4; Collapsin response mediator protein 4; DRP-3; TOAD-64/Ulip/CRMP; TUC-4b", "protein_names_refseq": "CRMP-4; DRP-3; TOAD-64/Ulip/CRMP protein 4b; collapsin response mediator protein 4; dihydropyrimidinase-related protein 3 isoform 1; dihydropyrimidinase-related protein 3", "tax_id": 10116, "disease": "cataract 2 multiple types (Disease Ontology:DOID:0110235); cataract (Disease Ontology:DOID:83); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:25418); (R-RNO-399956)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "12444086;12684468;16611631;18683930;19343716;22673903;23988434;26064693;27339813;38063003;38843836;8815901;9375656", "class_list": "", "function": "Data suggest collapsin response mediator proteins (CRMP) CRMP2 and CRMP4 form complexes to bridge microtubules and actin and work cooperatively to regulate growth cone development and axonal elongation., [RefSeq, PubMed]; In neonatal rat brain, interacts with chondroitin sulfate and other glycosaminoglycans, [RefSeq, PubMed]; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Regulation of Dihydropyrimidinase-like 3 Gene Expression by MicroRNAs in PC12 Cells with Induced Ischaemia and Hypothermia., [RefSeq, PubMed]; TUC-4b can regulate neurite extension and branching through a mechanism that may involve membrane transport in the growth cone, [RefSeq, PubMed]; The results of this study suggest that CRMP4 is involved in dendritic development via the interaction with actin cytoskeleton in hippocampal neurons., [RefSeq, PubMed]; The results of this study suggested that knockdown of Dpysl3 can inhibit activation, migration and phagocytic capability of microglia and consequently reduce neuroinflammation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4H3;Q91XM8", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0051219 phosphoprotein binding;GO:0035374 chondroitin sulfate binding;GO:0031005 filamin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0030426 growth cone;GO:0045202 synapse", "go_biological_process": "GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0030336 negative regulation of cell migration;GO:0010977 negative regulation of neuron projection development;GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q62952-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK09-1", "uniprot_id": [ { "id": "DRAM2_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK09", "type": "external" } ], "mass": 30173.0, "length": 267, "protein_name": "DNA damage-regulated autophagy modulator protein 2", "gene_name": "Dram2", "organism": "Rat", "refseq_name": "DNA damage-regulated autophagy modulator protein 2", "refseq_ac": [ { "id": "NP_001020189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020189", "type": "external" } ], "gene_names_uniprotkb": "Dram2; Tmem77", "gene_names_refseq": "Dram2; Tmem77", "protein_names_uniprotkb": "DNA damage-regulated autophagy modulator protein 2; Transmembrane protein 77", "protein_names_refseq": "DNA damage-regulated autophagy modulator protein 2; transmembrane protein 77", "tax_id": 10116, "disease": "cone-rod dystrophy 21 (Disease Ontology:DOID:0081447)", "pathway": " (rno:362011)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0008283 cell population proliferation;GO:0010506 regulation of autophagy;GO:0006915 apoptotic process;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK09-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY92-1", "uniprot_id": [ { "id": "CTL3_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY92", "type": "external" } ], "mass": 67679.0, "length": 604, "protein_name": "Choline transporter-like protein 3", "gene_name": "Slc44a3", "organism": "Rat", "refseq_name": "choline transporter-like protein 3 isoform 1", "refseq_ac": [ { "id": "NP_001013936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013936", "type": "external" } ], "gene_names_uniprotkb": "Slc44a3; Ctl3", "gene_names_refseq": "RGD1305808; Slc44a3", "protein_names_uniprotkb": "Choline transporter-like protein 3; Solute carrier family 44 member 3", "protein_names_refseq": "choline transporter-like protein 3 isoform 1; choline transporter-like protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:295417); (R-RNO-1483191); (R-RNO-9958517)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15715662", "class_list": "", "function": "Choline transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0015695 organic cation transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AY92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HE7-1", "uniprot_id": [ { "id": "CDKL1_RAT", "url": "https://www.uniprot.org/uniprot/Q66HE7", "type": "external" } ], "mass": 40899.0, "length": 352, "protein_name": "Cyclin-dependent kinase-like 1", "gene_name": "Cdkl1", "organism": "Rat", "refseq_name": "cyclin-dependent kinase-like 1", "refseq_ac": [ { "id": "NP_001020292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020292", "type": "external" } ], "gene_names_uniprotkb": "Cdkl1", "gene_names_refseq": "Cdkl1", "protein_names_uniprotkb": "Cyclin-dependent kinase-like 1; 2.7.11.22", "protein_names_refseq": "cyclin-dependent kinase-like 1 (CDC2-related kinase); cyclin-dependent kinase-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:314198)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0007507 heart development;GO:1902017 regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HE7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXW7-1", "uniprot_id": [ { "id": "DUS18_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXW7", "type": "external" } ], "mass": 22754.0, "length": 204, "protein_name": "Dual specificity protein phosphatase 18", "gene_name": "Dusp18", "organism": "Rat", "refseq_name": "dual specificity protein phosphatase 18", "refseq_ac": [ { "id": "NP_001013146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013146", "type": "external" } ], "gene_names_uniprotkb": "Dusp18", "gene_names_refseq": "Dusp18", "protein_names_uniprotkb": "Dual specificity protein phosphatase 18; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 18", "tax_id": 10116, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404)", "pathway": " (rno:305477)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18385140", "class_list": "", "function": "Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). In bone tissue, upon activation of the G(q)-dependent KISS1/KISS1R signaling pathway, DUSP18 is recruited to the KISS1R C-terminus, where it dephosphorylates SRC resulting in down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0016311 dephosphorylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0045779 negative regulation of bone resorption;GO:0035970 peptidyl-threonine dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXW7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64346-1", "uniprot_id": [ { "id": "DUS6_RAT", "url": "https://www.uniprot.org/uniprot/Q64346", "type": "external" } ], "mass": 42319.0, "length": 381, "protein_name": "Dual specificity protein phosphatase 6", "gene_name": "Dusp6", "organism": "Rat", "refseq_name": "dual specificity protein phosphatase 6", "refseq_ac": [ { "id": "NP_446335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446335", "type": "external" } ], "gene_names_uniprotkb": "Dusp6; Mkp3", "gene_names_refseq": "Dusp6; Mkp3", "protein_names_uniprotkb": "Dual specificity protein phosphatase 6; 3.1.3.16; 3.1.3.48; MAP kinase phosphatase 3; MKP-3; Mitogen-activated protein kinase phosphatase 3", "protein_names_refseq": "MAP kinase phosphatase 3; MKP-3; dual specificity protein phosphatase 6; mitogen-activated protein kinase phosphatase 3", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 19 with or without anosmia (Disease Ontology:DOID:0090090); breast cancer (Disease Ontology:DOID:1612); brain ischemia (Disease Ontology:DOID:2316); pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (rno:116663); (R-RNO-112409); (R-RNO-202670); (R-RNO-5675221)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "30816666;34944046;35630630;36335128;8626780;8631996", "class_list": "", "function": "Characterization of Type 1 Angiotensin II Receptor Activation Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes in Rat Vascular Smooth Muscle Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Data support the notion that p38-MAPK activation after myocardial stretch restricts the SFR by limiting ERK1/2-p90RSK phosphorylation, and consequently NHE-1 phosphorylation/activity, through a mechanism that involves DUSP6 up-regulation., [RefSeq, PubMed]; Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8626780). Has a specificity for the ERK family (PubMed:8626780). Implicated in muscle and neuronal differentiation (PubMed:8631996). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction. Publication Status: Online-Only, [RefSeq, PubMed]; Neuroprotective Effect of Dioscin against Parkinson's Disease via Adjusting Dual-Specificity Phosphatase 6 (DUSP6)-Mediated Oxidative Stress. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0060420 regulation of heart growth;GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0051409 response to nitrosative stress", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64346-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJY4-1", "uniprot_id": [ { "id": "PEXRP_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJY4", "type": "external" } ], "mass": 35342.0, "length": 325, "protein_name": "Peroxisomal reductase activating PPAR-gamma", "gene_name": "Dhrs7b", "organism": "Rat", "refseq_name": "peroxisomal reductase activating PPAR-gamma", "refseq_ac": [ { "id": "NP_001008507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008507", "type": "external" } ], "gene_names_uniprotkb": "Dhrs7b; Sdr32c1", "gene_names_refseq": "Dhrs7b; PexRAP; RGD1311243", "protein_names_uniprotkb": "Peroxisomal reductase activating PPAR-gamma; 1.1.1.101; Dehydrogenase/reductase SDR family member 7B; PexRAP; Protein SDR32C1; Short-chain dehydrogenase/reductase family 32C member 1", "protein_names_refseq": "SDR family dehydrogenase/reductase member 7B; dehydrogenase/reductase (SDR family) member 7B; peroxisomal reductase activating PPAR-gamma; short-chain dehydrogenase/reductase family 32C member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:287380); (R-RNO-75896)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17522052;18775470;38843836", "class_list": "", "function": "Reductase required for adipogenesis and activation of PPARG nuclear receptor. Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively, synthesizing ether-linked phospholipids that act as agonists for PPARG. Also regulates adipogenesis by preventing adipocyte browning: following import into the nucleus, interacts with PRDM16, inhibiting the interaction between PRDM16 and PPARG and preventing differentiation of brown adipocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The localization studies on rat short-chain dehydrogenases/reductases dhrs7b and dhrs8, are shown., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4GWE3", "ec_number_list": [ { "id": "1.1.1.101", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.101", "type": "external" } ], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0000140 acylglycerone-phosphate reductase (NADP+) activity;GO:0140297 DNA-binding transcription factor binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005634 nucleus;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0008611 ether lipid biosynthetic process;GO:0050873 brown fat cell differentiation;GO:0060612 adipose tissue development;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5RJY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQV2-1", "uniprot_id": [ { "id": "DOK1_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQV2", "type": "external" } ], "mass": 52170.0, "length": 480, "protein_name": "Docking protein 1", "gene_name": "Dok1", "organism": "Rat", "refseq_name": "docking protein 1", "refseq_ac": [ { "id": "NP_001020587", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020587", "type": "external" } ], "gene_names_uniprotkb": "Dok1", "gene_names_refseq": "Dok-1; Dok1", "protein_names_uniprotkb": "Docking protein 1; Downstream of tyrosine kinase 1", "protein_names_refseq": "docking protein 1; downstream of tyrosine kinase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:312477); (R-RNO-8849469); (R-RNO-8853659)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15608142", "class_list": "", "function": "DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity)., [UniProtKB]; Dok-1 is the mediator of the antiallergic actions of dexamethasone and as a negative regulator of the MAP kinase pathway and downstream release of inflammatory mediators., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0038145 macrophage colony-stimulating factor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0035556 intracellular signal transduction;GO:0007265 Ras protein signal transduction;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4QQV2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2W7-1", "uniprot_id": [ { "id": "CYAC3_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2W7", "type": "external" } ], "mass": 28650.0, "length": 256, "protein_name": "Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3", "gene_name": "Cyb561a3", "organism": "Rat", "refseq_name": "lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 19", "refseq_ac": [ { "id": "NP_001014186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014186", "type": "external" } ], "gene_names_uniprotkb": "Cyb561a3; Cybasc3", "gene_names_refseq": "Cyb561a3; Cybasc3; RGD1304670", "protein_names_uniprotkb": "Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3; 7.2.1.3; Cytochrome b ascorbate-dependent protein 3; Cytochrome b561 family member A3; LCytb; Lysosomal cytochrome b", "protein_names_refseq": "LCytb; cytochrome b ascorbate-dependent protein 3; cytochrome b, ascorbate dependent 3; lysosomal cytochrome b; lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 19; lysosomal membrane ascorbate-dependent ferrireductase CYB561A3", "tax_id": 10116, "disease": "", "pathway": " (rno:361729)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0140571 transmembrane ascorbate ferrireductase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2W7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DKG0-1", "uniprot_id": [ { "id": "NAA35_RAT", "url": "https://www.uniprot.org/uniprot/Q6DKG0", "type": "external" } ], "mass": 83210.0, "length": 725, "protein_name": "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "gene_name": "Naa35", "organism": "Rat", "refseq_name": "N-alpha-acetyltransferase 35, NatC auxiliary subunit", "refseq_ac": [ { "id": "NP_579858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579858", "type": "external" } ], "gene_names_uniprotkb": "Naa35; Egap; Emb8; Mak10", "gene_names_refseq": "Mak10; Naa35; T4a", "protein_names_uniprotkb": "N-alpha-acetyltransferase 35, NatC auxiliary subunit; Corneal wound-healing-related protein; Embryonic growth-associated protein; Protein MAK10 homolog", "protein_names_refseq": "N-alpha-acetyltransferase 35, NatC auxiliary subunit; RAT52; corneal wound-healing-related protein; embryonic growth-associated protein; protein MAK10 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:64472)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10855038;11009567;16484612", "class_list": "", "function": "Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway. Involved in regulation of apoptosis and proliferation of smooth muscle cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JI01", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031417 NatC complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0048659 smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6DKG0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FY1-1", "uniprot_id": [ { "id": "NUP35_RAT", "url": "https://www.uniprot.org/uniprot/Q68FY1", "type": "external" } ], "mass": 34802.0, "length": 325, "protein_name": "Nucleoporin NUP35", "gene_name": "Nup35", "organism": "Rat", "refseq_name": "nucleoporin NUP35", "refseq_ac": [ { "id": "NP_001004229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004229", "type": "external" } ], "gene_names_uniprotkb": "Nup35; Nup53", "gene_names_refseq": "Nup35", "protein_names_uniprotkb": "Nucleoporin NUP35; 35 kDa nucleoporin; Nuclear pore complex protein Nup53; Nucleoporin NUP53", "protein_names_refseq": "35 kDa nucleoporin; mitotic phosphoprotein 44; nuclear pore complex protein Nup53; nucleoporin NUP35; nucleoporin NUP53", "tax_id": 10116, "disease": "intestinal pseudo-obstruction (Disease Ontology:DOID:0080072)", "pathway": " (rno:295692); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-9615933)", "pathway_count": 19, "publication_count": 3, "publication_id_list": "15703211;22673903;29393594", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0005652 nuclear lamina;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0006999 nuclear pore organization;GO:1990830 cellular response to leukemia inhibitory factor;GO:0051028 mRNA transport;GO:0006607 NLS-bearing protein import into nucleus;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q68FY1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TT51-1", "uniprot_id": [ { "id": "LGSN_RAT", "url": "https://www.uniprot.org/uniprot/Q7TT51", "type": "external" } ], "mass": 62269.0, "length": 561, "protein_name": "Lengsin", "gene_name": "Lgsn", "organism": "Rat", "refseq_name": "lengsin", "refseq_ac": [ { "id": "NP_852048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852048", "type": "external" } ], "gene_names_uniprotkb": "Lgsn; Gluld1; Lgs", "gene_names_refseq": "Gluld1; Lgsn; Lgs", "protein_names_uniprotkb": "Lengsin; Glutamate-ammonia ligase domain-containing protein 1; Lens glutamine synthase-like", "protein_names_refseq": "glutamate-ammonia ligase (glutamine synthase) domain containing 1; glutamate-ammonia ligase (glutamine synthetase) domain containing 1; glutamate-ammonia ligase domain-containing protein 1; lengsin", "tax_id": 10116, "disease": "", "pathway": " (rno:316304)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003824 catalytic activity;GO:0004356 glutamine synthetase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006542 glutamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TT51-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0E2-1", "uniprot_id": [ { "id": "PHF11_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0E2", "type": "external" } ], "mass": 37214.0, "length": 336, "protein_name": "PHD finger protein 11", "gene_name": "LOC120093163; LOC134482125; Phf11; Setdb2", "organism": "Rat", "refseq_name": "PHD finger protein 11", "refseq_ac": [ { "id": "NP_001019443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019443", "type": "external" } ], "gene_names_uniprotkb": "LOC120093163; LOC134482125; Phf11; Setdb2; LOC120093070; LOC120093163; LOC134482125; Phf11", "gene_names_refseq": "Phf11a; Phf11", "protein_names_uniprotkb": "PHD finger protein 11", "protein_names_refseq": "PHD finger protein 11 family member-like; PHD finger protein 11a; PHD finger protein 11", "tax_id": 10116, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); allergic disease (Disease Ontology:DOID:1205); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (rno:100361710); (rno:361051); (R-RNO-3214841)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Positive regulator of Th1-type cytokine gene expression., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003677 DNA binding;GO:0046974 histone H3K9 methyltransferase activity;GO:0140947 histone H3K9me2 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005694 chromosome;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0E2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BKD0-1", "uniprot_id": [ { "id": "OAS1B_RAT", "url": "https://www.uniprot.org/uniprot/Q5BKD0", "type": "external" } ], "mass": 44122.0, "length": 379, "protein_name": "Inactive 2'-5'-oligoadenylate synthase 1B", "gene_name": "Oas1b; Oas1h; Oas1k", "organism": "Rat", "refseq_name": "inactive 2'-5'-oligoadenylate synthase 1B", "refseq_ac": [ { "id": "NP_653353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653353", "type": "external" } ], "gene_names_uniprotkb": "Oas1b; Oas1h; Oas1k; Oas1f; Oas1h", "gene_names_refseq": "Oas1b", "protein_names_uniprotkb": "Inactive 2'-5'-oligoadenylate synthase 1B; (2-5')oligo(A) synthase 1B; 2-5A synthase 1B", "protein_names_refseq": "(2-5')oligo(A) synthase 1B; 2'5' oligoadenylate synthetase-2; 2-5A synthase 1B; 25 oligoadenylate synthetase-2; inactive 2'-5'-oligoadenylate synthase 1B", "tax_id": 10116, "disease": "immunodeficiency 100 (Disease Ontology:DOID:0061070)", "pathway": " (rno:246268)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12650929;17024523;29393594", "class_list": "", "function": "Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against viruses via an alternative antiviral pathway independent of RNase L (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70522", "ec_number_list": [ { "id": "2.7.7.84", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.84", "type": "external" } ], "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0016779 nucleotidyltransferase activity;GO:0003723 RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway;GO:0009615 response to virus;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5BKD0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64201-1", "uniprot_id": [ { "id": "OTX2_RAT", "url": "https://www.uniprot.org/uniprot/Q64201", "type": "external" } ], "mass": 7139.0, "length": 70, "protein_name": "Homeobox protein OTX2", "gene_name": "Otx2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Otx2", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein OTX2; Orthodenticle homolog 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "combined pituitary hormone deficiency 6 (Disease Ontology:DOID:0061022); syndromic microphthalmia 5 (Disease Ontology:DOID:0111806)", "pathway": " (rno:305858)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8613727", "class_list": "", "function": "Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030426 growth cone;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0048852 diencephalon morphogenesis;GO:0001708 cell fate specification;GO:0022037 metencephalon development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64201-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62997-1", "uniprot_id": [ { "id": "GFRA1_RAT", "url": "https://www.uniprot.org/uniprot/Q62997", "type": "external" } ], "mass": 51650.0, "length": 468, "protein_name": "GDNF family receptor alpha-1", "gene_name": "Gfra1", "organism": "Rat", "refseq_name": "GDNF family receptor alpha-1 precursor", "refseq_ac": [ { "id": "NP_037091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037091", "type": "external" } ], "gene_names_uniprotkb": "Gfra1; AABR07007068.1; Gdnfra; Retl1; Trnr1", "gene_names_refseq": "Gfra1", "protein_names_uniprotkb": "GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1", "protein_names_refseq": "GDNF family receptor alpha-1 precursor; GDNF family receptor alpha-1-like; GDNF receptor alpha-1; GDNF receptor alpha; GDNFR-alpha-1; GDNFR-alpha; GFR-alpha-1; Glial cell line-derived neurotrophic factor receptor alpha; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1; glial cell line derived neurotrophic factor family receptor alpha 1", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); lung non-squamous non-small cell carcinoma (Disease Ontology:DOID:0080521); Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); appendiceal neoplasm (Disease Ontology:DOID:11240); sciatic neuropathy (Disease Ontology:DOID:11446); leukemia (Disease Ontology:DOID:1240); renal agenesis (Disease Ontology:DOID:14766); neuroendocrine tumor (Disease Ontology:DOID:169); pancreatic endocrine carcinoma (Disease Ontology:DOID:1798); islet cell tumor (Disease Ontology:DOID:1799); ovary epithelial cancer (Disease Ontology:DOID:2152); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); transitional cell carcinoma (Disease Ontology:DOID:2671); Churg-Strauss syndrome (Disease Ontology:DOID:3049); clear cell adenocarcinoma (Disease Ontology:DOID:4468); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (rno:25454); (R-RNO-5673001); (R-RNO-8853659)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10719212;15044950;23333276;25043933;25242331;26599339;30541958;37178997;8657309;8674117;9177201", "class_list": "", "function": "Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:8674117). GDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed:25242331, PubMed:8674117)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Differential expression of RET and GDNF family receptor, GFR-alpha1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling., [RefSeq, PubMed]; Exercise-Mediated Increase in Nigral gfra1 in aging rats., [RefSeq, PubMed]; The findings demonstrate that elevated GDNF levels can reduce the retinal injury, whereby down-regulated miR-216a aggravates the YAG laser-induced retinal injury by targeting the GDNF level through the GDNF/GFRa1/RET signaling pathway., [RefSeq, PubMed]; These studies reveal a diverse range of potential targets by which artemin could influence bladder function, nerve regeneration, and pain., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005030 neurotrophin receptor activity;GO:0038023 signaling receptor activity;GO:0016167 glial cell-derived neurotrophic factor receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62997-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9U8-1", "uniprot_id": [ { "id": "EIF3H_RAT", "url": "https://www.uniprot.org/uniprot/Q6P9U8", "type": "external" } ], "mass": 39905.0, "length": 352, "protein_name": "Eukaryotic translation initiation factor 3 subunit H", "gene_name": "Eif3h", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 3 subunit H", "refseq_ac": [ { "id": "NP_942046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942046", "type": "external" } ], "gene_names_uniprotkb": "Eif3h; EIF3H; EIF3S3; Eif3s3", "gene_names_refseq": "Eif3h; Eif3s3; eIF-3-gamma", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit H; Eukaryotic translation initiation factor 3 subunit 3; eIF-3-gamma; eIF3 p40 subunit; eIF3h", "protein_names_refseq": "eIF3 p40 subunit; eukaryotic translation initiation factor 3 subunit 3; eukaryotic translation initiation factor 3 subunit H; eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (rno:299899); (R-RNO-156827); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0003743 translation initiation factor activity;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P9U8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJP2-1", "uniprot_id": [ { "id": "CWC15_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJP2", "type": "external" } ], "mass": 26638.0, "length": 229, "protein_name": "Spliceosome-associated protein CWC15 homolog", "gene_name": "Cwc15", "organism": "Rat", "refseq_name": "spliceosome-associated protein CWC15 homolog", "refseq_ac": [ { "id": "NP_001020158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020158", "type": "external" } ], "gene_names_uniprotkb": "Cwc15; Cwc15-ps3", "gene_names_refseq": "Cwc15; RGD1310669", "protein_names_uniprotkb": "Spliceosome-associated protein CWC15 homolog", "protein_names_refseq": "CWC15 spliceosome-associated protein homolog; protein CWC15 homolog; spliceosome-associated protein CWC15 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:300361); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM45-1", "uniprot_id": [ { "id": "ADSSP_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM45", "type": "external" } ], "mass": 19456.0, "length": 174, "protein_name": "Adipose-secreted signaling protein", "gene_name": "Adissp; Hspa12b", "organism": "Rat", "refseq_name": "adipose-secreted signaling protein", "refseq_ac": [ { "id": "NP_001020862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020862", "type": "external" } ], "gene_names_uniprotkb": "Adissp; Hspa12b", "gene_names_refseq": "Adissp; RGD1311739", "protein_names_uniprotkb": "Adipose-secreted signaling protein", "protein_names_refseq": "UPF0687 protein C20orf27 homolog; adipose-secreted signaling protein", "tax_id": 10116, "disease": "", "pathway": " (rno:311427); (rno:311428); (R-RNO-3371453)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Adipocyte-secreted protein (adipokine) that acts as a key regulator for white adipose tissue (WAT) thermogenesis and glucose homeostasis at least in part through activation of protein kinase A (PKA)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0042593 glucose homeostasis;GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway;GO:1990845 adaptive thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM45-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62774-1", "uniprot_id": [ { "id": "MYO1A_RAT", "url": "https://www.uniprot.org/uniprot/Q62774", "type": "external" } ], "mass": 97211.0, "length": 842, "protein_name": "Unconventional myosin-Ia", "gene_name": "Myo1a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myo1a; Bbmi; Myhl", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-Ia; BBM-I; BBMI; Brush border myosin I; MIHC; Myosin I heavy chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (rno:299509)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;7779104", "class_list": "", "function": "Involved in directing the movement of organelles along actin filaments., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0015629 actin cytoskeleton;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0030033 microvillus assembly;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0032880 regulation of protein localization;GO:0030048 actin filament-based movement", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62774-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64202-1", "uniprot_id": [ { "id": "DLX1_RAT", "url": "https://www.uniprot.org/uniprot/Q64202", "type": "external" } ], "mass": 4451.0, "length": 44, "protein_name": "Homeobox protein DLX-1", "gene_name": "Dlx1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dlx1", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein DLX-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:296500)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8613727", "class_list": "", "function": "Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus;GO:0021879 forebrain neuron differentiation;GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0021544 subpallium development;GO:0021893 cerebral cortex GABAergic interneuron fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64202-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63251-1", "uniprot_id": [ { "id": "FOXD1_RAT", "url": "https://www.uniprot.org/uniprot/Q63251", "type": "external" } ], "mass": 11929.0, "length": 101, "protein_name": "Forkhead box protein D1", "gene_name": "Foxd1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Foxd1; Hfhbf2", "gene_names_refseq": "", "protein_names_uniprotkb": "Forkhead box protein D1; BF-2; Brain factor 2; HFH-BF-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171299)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7683413", "class_list": "", "function": "Transcription factor involved in regulation of gene expression in a variety of processes including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0032275 luteinizing hormone secretion;GO:0072268 pattern specification involved in metanephros development;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63251-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WA4-1", "uniprot_id": [ { "id": "NOVA1_RAT", "url": "https://www.uniprot.org/uniprot/Q80WA4", "type": "external" } ], "mass": 48444.0, "length": 474, "protein_name": "RNA-binding protein Nova-1", "gene_name": "Nova1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nova1", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA-binding protein Nova-1; Neuro-oncological ventral antigen 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:298992)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12124753", "class_list": "", "function": "RNA-binding protein which regulates alternative splicing of pre-mRNAs in the brain and spinal cord in a sequence-specific manner. Binds to 5'-YCAY-3' repeats, with a minimum of 2 to 3 repeats necessary for high-affinity binding. Mediates both exon inclusion and exclusion, depending upon the position of its binding site within the pre-mRNA Binding to 5'-YCAY-3' clusters results in a local and asymmetric action to regulate spliceosome assembly. Binding to an exonic 5'-YCAY-3' cluster changes the protein complexes assembled on pre-mRNA, blocking U1 small nuclear ribonucleoprotein (snRNP) binding and inhibiting exon inclusion, whereas binding to an intronic 5'-YCAY-3' repeat enhances spliceosome assembly and favors exon inclusion. Regulates the splicing of gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), among others (By similarity). Also regulates the splicing of glycine receptor subunit alpha-2 (GLRA2) pre-mRNAs (PubMed:12124753)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051252 regulation of RNA metabolic process;GO:0007399 nervous system development;GO:0021510 spinal cord development;GO:0000398 mRNA splicing, via spliceosome;GO:0050684 regulation of mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80WA4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7A6-1", "uniprot_id": [ { "id": "PHF10_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7A6", "type": "external" } ], "mass": 55884.0, "length": 497, "protein_name": "PHD finger protein 10", "gene_name": "Phf10; Wdr27", "organism": "Rat", "refseq_name": "PHD finger protein 10", "refseq_ac": [ { "id": "NP_001019918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019918", "type": "external" } ], "gene_names_uniprotkb": "Phf10; Wdr27; Baf45a; Phf10", "gene_names_refseq": "BAF45a; Phf10", "protein_names_uniprotkb": "PHD finger protein 10; BAF45a; BRG1-associated factor 45a", "protein_names_refseq": "BRG1-associated factor 45a; PHD finger protein 10", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); Coffin-Siris syndrome (Disease Ontology:DOID:1925)", "pathway": " (rno:292404); (rno:308222); (R-RNO-9933939); (R-RNO-9933946); (R-RNO-9934037)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071564 npBAF complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:1990403 embryonic brain development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7A6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZAU7-1", "uniprot_id": [ { "id": "CENPL_RAT", "url": "https://www.uniprot.org/uniprot/Q3ZAU7", "type": "external" } ], "mass": 39460.0, "length": 345, "protein_name": "Centromere protein L", "gene_name": "Cenpl", "organism": "Rat", "refseq_name": "centromere protein L isoform 1", "refseq_ac": [ { "id": "NP_001028233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028233", "type": "external" } ], "gene_names_uniprotkb": "Cenpl", "gene_names_refseq": "Cenpl; RGD1311868", "protein_names_uniprotkb": "Centromere protein L; CENP-L", "protein_names_refseq": "CENP-L; centromere protein L isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:289150); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-606279); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5Q6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0000775 chromosome, centromeric region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3ZAU7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QI25-1", "uniprot_id": [ { "id": "ORML3_RAT", "url": "https://www.uniprot.org/uniprot/Q6QI25", "type": "external" } ], "mass": 17463.0, "length": 153, "protein_name": "ORM1-like protein 3", "gene_name": "Ormdl3", "organism": "Rat", "refseq_name": "ORM1-like protein 3", "refseq_ac": [ { "id": "NP_001400222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001400222", "type": "external" } ], "gene_names_uniprotkb": "Ormdl3", "gene_names_refseq": "LRRGT00183; Ormdl3", "protein_names_uniprotkb": "ORM1-like protein 3; Liver regeneration-related protein LRRGT00183", "protein_names_refseq": "ORM1-like 3; ORM1-like protein 3; liver regeneration-related protein LRRGT00183", "tax_id": 10116, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); asthma (Disease Ontology:DOID:2841); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (rno:360618); (R-RNO-1660661); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1900060 negative regulation of ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006672 ceramide metabolic process;GO:0010508 positive regulation of autophagy;GO:1900182 positive regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6QI25-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P730-1", "uniprot_id": [ { "id": "DAB2P_RAT", "url": "https://www.uniprot.org/uniprot/Q6P730", "type": "external" } ], "mass": 110005.0, "length": 996, "protein_name": "Disabled homolog 2-interacting protein", "gene_name": "Dab2ip", "organism": "Rat", "refseq_name": "disabled homolog 2-interacting protein", "refseq_ac": [ { "id": "NP_619724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619724", "type": "external" } ], "gene_names_uniprotkb": "Dab2ip", "gene_names_refseq": "AIP-1; DIP1/2; Dab2ip", "protein_names_uniprotkb": "Disabled homolog 2-interacting protein; AIP-1; ASK-interacting protein 1; DAB2-interacting protein; DIP1/2; DOC-2/DAB2 interactive protein", "protein_names_refseq": "ASK-interacting protein 1; DOC-2/DAB2 interactive protein; DOC2/DAB2 interactive protein; disabled homolog 2-interacting protein", "tax_id": 10116, "disease": "peripheral artery disease (Disease Ontology:DOID:0050830); developmental disorder of mental health (Disease Ontology:DOID:0060037); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); lung cancer (Disease Ontology:DOID:1324); atherosclerosis (Disease Ontology:DOID:1936); coronary artery disease (Disease Ontology:DOID:3393); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (rno:192126); (R-RNO-5658442)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11812785;22673903;38843836", "class_list": "", "function": "Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Also plays a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to pro-inflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6). Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Also functions as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively (By similarity). Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Functions as a Ras GTPase-activating protein. May act as a tumor suppressor gene., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q924M9", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:1900744 regulation of p38MAPK cascade;GO:0010633 negative regulation of epithelial cell migration;GO:0046580 negative regulation of Ras protein signal transduction;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P730-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7U4-1", "uniprot_id": [ { "id": "CTU2_RAT", "url": "https://www.uniprot.org/uniprot/Q3B7U4", "type": "external" } ], "mass": 57759.0, "length": 528, "protein_name": "Cytoplasmic tRNA 2-thiolation protein 2", "gene_name": "Ctu2", "organism": "Rat", "refseq_name": "cytoplasmic tRNA 2-thiolation protein 2", "refseq_ac": [ { "id": "NP_001032171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032171", "type": "external" } ], "gene_names_uniprotkb": "Ctu2; CTU2; NCS2; Ncs2", "gene_names_refseq": "Ctu2; Ncs2", "protein_names_uniprotkb": "Cytoplasmic tRNA 2-thiolation protein 2", "protein_names_refseq": "cytoplasmic tRNA 2-thiolation protein 2; cytosolic thiouridylase subunit 2 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:292069)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19017811", "class_list": "", "function": "Identifies a similar human protein that is involved in tRNA modification., [RefSeq, PubMed]; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LQR2;Q5FVN4;Q6AXQ6", "ec_number_list": [], "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0000049 tRNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3B7U4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64270-1", "uniprot_id": [ { "id": "EI2BA_RAT", "url": "https://www.uniprot.org/uniprot/Q64270", "type": "external" } ], "mass": 33678.0, "length": 305, "protein_name": "Translation initiation factor eIF2B subunit alpha", "gene_name": "Eif2b1", "organism": "Rat", "refseq_name": "translation initiation factor eIF2B subunit alpha", "refseq_ac": [ { "id": "NP_742026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742026", "type": "external" } ], "gene_names_uniprotkb": "Eif2b1; Eif2ba", "gene_names_refseq": "Eif2b1; eIF-2a", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit alpha; eIF2B GDP-GTP exchange factor subunit alpha", "protein_names_refseq": "GTP-exchange protein; eIF-2B GDP-GTP exchange factor subunit alpha; eIF-2Balpha; eIF2B GDP-GTP exchange factor subunit alpha; eukaryotic translation initiation factor 2B subunit 1 alpha; translation initiation factor eIF-2B subunit alpha; translation initiation factor eIF2B subunit alpha", "tax_id": 10116, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 1 (Disease Ontology:DOID:0070374)", "pathway": " (rno:64514); (R-RNO-72731)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "7495858;7753796", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity;GO:0019003 GDP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005851 eukaryotic translation initiation factor 2B complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0050852 T cell receptor signaling pathway;GO:0006413 translational initiation;GO:0006412 translation;GO:1990928 response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64270-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8A0-1", "uniprot_id": [ { "id": "NSE2_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8A0", "type": "external" } ], "mass": 28246.0, "length": 247, "protein_name": "E3 SUMO-protein ligase NSE2", "gene_name": "Nsmce2", "organism": "Rat", "refseq_name": "E3 SUMO-protein ligase NSE2", "refseq_ac": [ { "id": "NP_001020047", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020047", "type": "external" } ], "gene_names_uniprotkb": "Nsmce2; Mms21", "gene_names_refseq": "Nsmce2; RGD1305156", "protein_names_uniprotkb": "E3 SUMO-protein ligase NSE2; 2.3.2.-; E3 SUMO-protein transferase NSE2; MMS21 homolog; Non-SMC element 2 homolog; Non-structural maintenance of chromosomes element 2 homolog", "protein_names_refseq": "E3 SUMO-protein ligase NSE2; E3 SUMO-protein transferase NSE2; MMS21 homolog; NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase; non-SMC element 2 homolog; non-SMC element 2, MMS21 homolog; non-structural maintenance of chromosomes element 2 homolog", "tax_id": 10116, "disease": "Seckel syndrome 10 (Disease Ontology:DOID:0070008); Bloom syndrome (Disease Ontology:DOID:2717)", "pathway": " (rno:299957); (R-RNO-3108214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0004842 ubiquitin-protein transferase activity;GO:0019789 SUMO transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016605 PML body;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0016925 protein sumoylation;GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0045842 positive regulation of mitotic metaphase/anaphase transition;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8A0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P501-1", "uniprot_id": [ { "id": "LAP4A_RAT", "url": "https://www.uniprot.org/uniprot/Q6P501", "type": "external" } ], "mass": 26784.0, "length": 233, "protein_name": "Lysosomal-associated transmembrane protein 4A", "gene_name": "Laptm4a", "organism": "Rat", "refseq_name": "lysosomal-associated transmembrane protein 4A", "refseq_ac": [ { "id": "NP_955416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955416", "type": "external" } ], "gene_names_uniprotkb": "Laptm4a", "gene_names_refseq": "Laptm4a", "protein_names_uniprotkb": "Lysosomal-associated transmembrane protein 4A", "protein_names_refseq": "lysosomal-associated protein transmembrane 4 alpha; lysosomal-associated protein transmembrane 4A; lysosomal-associated transmembrane protein 4A", "tax_id": 10116, "disease": "", "pathway": " (rno:298875)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0097213 regulation of lysosomal membrane permeability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P501-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62902-1", "uniprot_id": [ { "id": "LMAN1_RAT", "url": "https://www.uniprot.org/uniprot/Q62902", "type": "external" } ], "mass": 57957.0, "length": 517, "protein_name": "Protein ERGIC-53", "gene_name": "Lman1", "organism": "Rat", "refseq_name": "protein ERGIC-53 precursor", "refseq_ac": [ { "id": "NP_446338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446338", "type": "external" } ], "gene_names_uniprotkb": "Lman1; Ergic53", "gene_names_refseq": "Lman1; p58", "protein_names_uniprotkb": "Protein ERGIC-53; ER-Golgi intermediate compartment 53 kDa protein; Lectin mannose-binding 1; p58", "protein_names_refseq": "ER-Golgi intermediate compartment 53 kDa protein; endoplasmic reticulum-golgi intermediate compartment protein 53; protein ERGIC-53 precursor; protein ERGIC-53", "tax_id": 10116, "disease": "factor XIII deficiency (Disease Ontology:DOID:2211); factor V deficiency (Disease Ontology:DOID:2216)", "pathway": " (rno:116666); (R-RNO-204005); (R-RNO-5694530); (R-RNO-8980692); (R-RNO-9013106); (R-RNO-9013404); (R-RNO-9013408); (R-RNO-9013423)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "11850423;14643651;8626736", "class_list": "", "function": "Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005509 calcium ion binding;GO:0005537 D-mannose binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62902-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8B0-1", "uniprot_id": [ { "id": "OXR1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8B0", "type": "external" } ], "mass": 92810.0, "length": 839, "protein_name": "Oxidation resistance protein 1", "gene_name": "Oxr1", "organism": "Rat", "refseq_name": "oxidation resistance protein 1 isoform 3", "refseq_ac": [ { "id": "NP_001184261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184261", "type": "external" } ], "gene_names_uniprotkb": "Oxr1; C7", "gene_names_refseq": "Oxr1", "protein_names_uniprotkb": "Oxidation resistance protein 1; Protein C7", "protein_names_refseq": "oxidation resistance protein 1 isoform 3; oxidation resistance protein 1; protein C7", "tax_id": 10116, "disease": "cerebellar hyplasia/atrophy, epilepsy, and global developmental delay (Disease Ontology:DOID:0070339)", "pathway": " (rno:117520)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11237729;18683930;22673903;29953904;30977043;32114118;32585243", "class_list": "", "function": "Contribution of reactive oxygen species via the OXR1 signaling pathway in the pathogenesis of monocrotaline-induced pulmonary arterial hypertension: The protective role of Crocin., [RefSeq, PubMed]; Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (By similarity). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (By similarity). Involved in protection from oxidative damage (By similarity). Protects neuronal cells from oxidative stress (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; May be involved in protection from oxidative damage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MicroRNA-365 up-regulation increases oxidative injury by inhibiting OXR1 expression, while its down-regulation protects neurons from oxidative death by enhancing OXR1-mediated antioxidant signals., [RefSeq, PubMed]; Orexin type-1 receptor inhibition in the rat lateral paragigantocellularis nucleus attenuates development of morphine dependence., [RefSeq, PubMed]; Results showed a deteriorating effect of OXR1 blockade on spatial memory consolidation in the Morris Water Maze, and that increased training is able to counteract such an effect. Additionally, although c-Fos expression cannot be linked to specific neuronal function, the c-Fos data seem to reproduce the behavioural results in a set of regions which have been linked to spatial memory., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B2RYF9;Q99MK0", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0051402 neuron apoptotic process;GO:0043524 negative regulation of neuron apoptotic process;GO:0007628 adult walking behavior;GO:0071447 cellular response to hydroperoxide", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q4V8B0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64663-1", "uniprot_id": [ { "id": "P2RX7_RAT", "url": "https://www.uniprot.org/uniprot/Q64663", "type": "external" } ], "mass": 68392.0, "length": 595, "protein_name": "P2X purinoceptor 7", "gene_name": "P2rx7", "organism": "Rat", "refseq_name": "P2X purinoceptor 7", "refseq_ac": [ { "id": "NP_062129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062129", "type": "external" } ], "gene_names_uniprotkb": "P2rx7", "gene_names_refseq": "P2rx7", "protein_names_uniprotkb": "P2X purinoceptor 7; ATP receptor; P2X7; P2Z receptor; Purinergic receptor", "protein_names_refseq": "ATP receptor; P2X purinoceptor 7-like; P2X purinoceptor 7; P2X7 purinoceptor; P2Z receptor; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (rno:29665); (R-RNO-139853); (R-RNO-418346); (R-RNO-844456)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10204537;17036048;18852304;19546214;24090084;31587896;36945903;37021698;38032425;38498358;39107314;39365862;8614837", "class_list": "", "function": "ATP-gated nonselective transmembrane cation channel that requires high millimolar concentrations of ATP for activation (PubMed:10204537, PubMed:39107314, PubMed:8614837). Upon ATP binding, it rapidly opens to allow the influx of small cations Na(+) and Ca(2+), and the K(+) efflux (PubMed:8614837). Also has the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules (PubMed:17036048, PubMed:18852304). In microglia, may mediate the transmembrane transport of exogenous NADPH (By similarity). In immune cells, P2RX7 acts as a molecular sensor in pathological inflammatory states by detecting and responding to high local concentrations of extracellar ATP. In microglial cells, P2RX7 activation leads to the release of pro-inflammatory cytokines, such as IL-1beta and IL-18, through the activation of the NLRP3 inflammasome and caspase-1. Cooperates with KCNK6 to activate NLRP3 inflammasome (By similarity). Activates death pathways leading to apoptosis and autophagy (By similarity). Activates death pathways leading to pyroptosis (By similarity). Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Senses ATP released from necrotic cells triggering activation of NLRP3 inflammasome and neutrophil adhesion to the vascular endothelium close to the injury site., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Deep learning structural insights into heterotrimeric alternatively spliced P2X7 receptors., [RefSeq, PubMed]; Has a higher affinity for ATP, slower deactivation and an increased propensity to form large cation-permeable pores., [UniProtKB, PubMed]; Identification of residues in the first transmembrane domain of the P2X7 that regulates receptor trafficking, sensitization, and dye uptake function., [RefSeq, PubMed]; LncTCONS_00058568 is involved in the pathophysiologic processes mediated by P2X7R in the lower thoracic spinal cord after acute kidney injury., [RefSeq, PubMed]; P2X7 receptors exhibit at least three modes of allosteric antagonism., [RefSeq, PubMed]; Pannexin 3 activates P2X7 receptor to mediate inflammation and cartilage matrix degradation in temporomandibular joint osteoarthritis., [RefSeq, PubMed]; Receptor for ATP that acts as a ligand-gated ion channel., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "C8YIX5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:0032730 positive regulation of interleukin-1 alpha production;GO:0071359 cellular response to dsRNA;GO:0051495 positive regulation of cytoskeleton organization;GO:0001934 positive regulation of protein phosphorylation;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "Q64663-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1X1-1", "uniprot_id": [ { "id": "ORN_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1X1", "type": "external" } ], "mass": 26752.0, "length": 237, "protein_name": "Oligoribonuclease, mitochondrial", "gene_name": "Rexo2", "organism": "Rat", "refseq_name": "oligoribonuclease, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001008327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008327", "type": "external" } ], "gene_names_uniprotkb": "Rexo2; Smfn", "gene_names_refseq": "Rexo2; Smfn", "protein_names_uniprotkb": "Oligoribonuclease, mitochondrial; 3.1.15.-; RNA exonuclease 2 homolog; Small fragment nuclease", "protein_names_refseq": "REX2, RNA exonuclease 2 homolog; RNA exonuclease 2 homolog; oligoribonuclease, mitochondrial precursor; oligoribonuclease, mitochondrial; small fragment nuclease", "tax_id": 10116, "disease": "", "pathway": " (rno:300689)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (By similarity). Binds and degrades longer oligonucleotides with a lower affinity (By similarity). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (By similarity). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (By similarity). Essential for embryonic development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0000287 magnesium ion binding;GO:0003676 nucleic acid binding;GO:0008408 3'-5' exonuclease activity;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006139 nucleobase-containing compound metabolic process;GO:2000827 mitochondrial RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U1X1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQQ6-1", "uniprot_id": [ { "id": "DRC9_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQQ6", "type": "external" } ], "mass": 48757.0, "length": 419, "protein_name": "Dynein regulatory complex protein 9", "gene_name": "Drc9", "organism": "Rat", "refseq_name": "dynein regulatory complex protein 9", "refseq_ac": [ { "id": "NP_001014252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014252", "type": "external" } ], "gene_names_uniprotkb": "Drc9; Iqcg", "gene_names_refseq": "Drc9; Iqcg", "protein_names_uniprotkb": "Dynein regulatory complex protein 9; IQ domain-containing protein G", "protein_names_refseq": "IQ domain-containing protein G; IQ motif containing G; dynein regulatory complex protein 9", "tax_id": 10116, "disease": "", "pathway": " (rno:363796)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0002177 manchette", "go_biological_process": "GO:0007286 spermatid development;GO:0044782 cilium organization;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQQ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KRD8-1", "uniprot_id": [ { "id": "IF6_RAT", "url": "https://www.uniprot.org/uniprot/Q3KRD8", "type": "external" } ], "mass": 26571.0, "length": 245, "protein_name": "Eukaryotic translation initiation factor 6", "gene_name": "Eif6", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 6", "refseq_ac": [ { "id": "NP_001032429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032429", "type": "external" } ], "gene_names_uniprotkb": "Eif6; EIF6; ITGB4BP; Itgb4bp", "gene_names_refseq": "Eif6; Itgb4bp; eIF-6", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 6; eIF-6", "protein_names_refseq": "eukaryotic translation initiation factor 6; integrin beta 4 binding protein", "tax_id": 10116, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:305506)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;29128355;39288622", "class_list": "", "function": "Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth., [UniProtKB, HAMAP, UniProtKB, UniProtKB]; Eukaryotic translation initiation factor 6-mediated ribosome biogenesis promotes synovial aggression and inflammation by increasing the translation of SP1 in rheumatoid arthritis., [RefSeq, PubMed]; Thus, this work uncovers a new translational cardiac regulator independent by other well-known factors such as mTOR signalling or eIF2beta., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0042304 regulation of fatty acid biosynthetic process;GO:0000054 ribosomal subunit export from nucleus;GO:0032868 response to insulin;GO:0045652 regulation of megakaryocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3KRD8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RFZ7-1", "uniprot_id": [ { "id": "PKHG5_RAT", "url": "https://www.uniprot.org/uniprot/Q6RFZ7", "type": "external" } ], "mass": 115784.0, "length": 1039, "protein_name": "Pleckstrin homology domain-containing family G member 5", "gene_name": "Plekhg5", "organism": "Rat", "refseq_name": "pleckstrin homology domain-containing family G member 5 isoform 3", "refseq_ac": [ { "id": "NP_958429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958429", "type": "external" } ], "gene_names_uniprotkb": "Plekhg5; Tech", "gene_names_refseq": "Plekhg5; Tech", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family G member 5; Neuronal RhoA GEF protein; PH domain-containing family G member 5; Transcript highly enriched in cortex and hippocampus", "protein_names_refseq": "PH domain-containing family G member 5; neuronal RhoA GEF protein; pleckstrin homology domain containing, family G (with RhoGef domain) member 5; pleckstrin homology domain-containing family G member 5 isoform 3; pleckstrin homology domain-containing family G member 5; transcript highly enriched in cortex and hippocampus", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease recessive intermediate C (Disease Ontology:DOID:0110198); autosomal recessive distal hereditary motor neuronopathy 4 (Disease Ontology:DOID:0111213)", "pathway": " (rno:310999); (R-RNO-193648); (R-RNO-416482); (R-RNO-8980692); (R-RNO-9696264); (R-RNO-9696273)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "15686487;16467373;22322975", "class_list": "", "function": "Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Also affects the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Tech regulates RhoA signaling pathways in developing and mature forebrain neurons., [RefSeq, PubMed]; This work thus identifies a group of RhoA-GEFs that controls RhoA and RhoA-dependent functions in vascular smooth muscle cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030027 lamellipodium;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0043542 endothelial cell migration;GO:0035767 endothelial cell chemotaxis;GO:0140251 regulation protein catabolic process at presynapse", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6RFZ7-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G033-1", "uniprot_id": [ { "id": "PIWL4_RAT", "url": "https://www.uniprot.org/uniprot/Q4G033", "type": "external" } ], "mass": 95971.0, "length": 848, "protein_name": "Piwi-like protein 4", "gene_name": "Piwil4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Piwil4", "gene_names_refseq": "", "protein_names_uniprotkb": "Piwi-like protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (rno:689972)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24930433;28711973", "class_list": "", "function": "Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins (By similarity). The PIWIL4-piRNA pathway acts in the nucleus and mediates silencing of active transposons: engages with nascent transposable element transcripts and governs the piRNA-directed DNA methylation and subsequent repression of transposons (By similarity). In contrast to PIWIL1 and PIWIL2, does not show endonuclease activity (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association (By similarity). The piRNA process acts upstream of known mediators of DNA methylation (By similarity). Does not show endonuclease activity (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-incompetent' component that loads cleaved piRNAs from the 'slicer-competent' component PIWIL2 and target them on genomic transposon loci in the nucleus (By similarity). In addition to its role in germline, PIWIL4 also plays a role in the regulation of somatic cells activities (By similarity). Plays a role in pancreatic beta cell function and insulin secretion (PubMed:28711973). Involved in maintaining cell morphology and functional integrity of retinal epithelial through Akt/GSK3alpha/beta signaling pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004521 RNA endonuclease activity;GO:0034584 piRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0071547 piP-body;GO:0043186 P granule", "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4G033-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U317-1", "uniprot_id": [ { "id": "FIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U317", "type": "external" } ], "mass": 60188.0, "length": 536, "protein_name": "Pre-mRNA 3'-end-processing factor FIP1", "gene_name": "Fip1l1", "organism": "Rat", "refseq_name": "pre-mRNA 3'-end-processing factor FIP1 isoform 1", "refseq_ac": [ { "id": "NP_001008296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008296", "type": "external" } ], "gene_names_uniprotkb": "Fip1l1", "gene_names_refseq": "Fip1l1", "protein_names_uniprotkb": "Pre-mRNA 3'-end-processing factor FIP1; FIP1-like 1 protein", "protein_names_refseq": "FIP1-like 1 protein; pre-mRNA 3'-end-processing factor FIP1 isoform 1; pre-mRNA 3'-end-processing factor FIP1", "tax_id": 10116, "disease": "", "pathway": " (rno:289582); (R-RNO-159231); (R-RNO-73856); (R-RNO-77595); (R-RNO-9770562)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage;GO:0031124 mRNA 3'-end processing;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U317-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63692-1", "uniprot_id": [ { "id": "CDC37_RAT", "url": "https://www.uniprot.org/uniprot/Q63692", "type": "external" } ], "mass": 44510.0, "length": 379, "protein_name": "Hsp90 co-chaperone Cdc37", "gene_name": "Cdc37", "organism": "Rat", "refseq_name": "hsp90 co-chaperone Cdc37", "refseq_ac": [ { "id": "NP_446195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446195", "type": "external" } ], "gene_names_uniprotkb": "Cdc37", "gene_names_refseq": "Cdc37", "protein_names_uniprotkb": "Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37", "protein_names_refseq": "CDC37 (cell division cycle 37 S. cerevisiae homolog); cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; hsp90 co-chaperone Cdc37; p50Cdc37", "tax_id": 10116, "disease": "", "pathway": " (rno:114562); (R-RNO-1227986); (R-RNO-5675482); (R-RNO-8863795); (R-RNO-9013418); (R-RNO-9652282)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "15082798;22673903;26362850;29687307;36642184;36920636;8534368;8945638", "class_list": "", "function": "Blocking Hsp90-Cdc37 interactions during pressure overload hypertrophy results in ubiquitin-mediated proteasomal degradation of TGFBR2 leading to termination of TGF beta mediated signaling. Erratum:[Cell Signal. 2020 Jan;65:109437. doi: 10.1016/j.cellsig.2019.109437. PMID: 31668398], [RefSeq, PubMed]; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibition of Cdc37 Ameliorates Arthritis in Collagen-Induced Arthritis Rats by Inhibiting Synoviocyte Proliferation and Migration Through the ERK Pathway., [RefSeq, PubMed]; Results unveil a regulatory mechanism of Cdc37, identify a molecular link between casein kinase 2 (CK2) and many crucial protein kinases via Cdc37, and reveal the molecular basis for the ability of CK2 to regulate pleiotropic cellular functions., [RefSeq, PubMed]; The expression of Cdc37 increased and reached a peak at one week after sciatic nerve crush., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CH95", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032587 ruffle membrane;GO:0032991 protein-containing complex;GO:1990565 HSP90-CDC37 chaperone complex", "go_biological_process": "GO:0010608 post-transcriptional regulation of gene expression;GO:0050821 protein stabilization;GO:0060338 regulation of type I interferon-mediated signaling pathway;GO:0006457 protein folding;GO:0060334 regulation of type II interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q63692-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5MYT7-1", "uniprot_id": [ { "id": "OAS3_RAT", "url": "https://www.uniprot.org/uniprot/Q5MYT7", "type": "external" } ], "mass": 126205.0, "length": 1137, "protein_name": "2'-5'-oligoadenylate synthase 3", "gene_name": "Oas3", "organism": "Rat", "refseq_name": "2'-5'-oligoadenylate synthase 3", "refseq_ac": [ { "id": "NP_001009493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009493", "type": "external" } ], "gene_names_uniprotkb": "Oas3", "gene_names_refseq": "Oas3", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthase 3; (2-5')oligo(A) synthase 3; 2-5A synthase 3; 2.7.7.84", "protein_names_refseq": "(2-5')oligo(A) synthase 3; 2'-5'-oligoadenylate synthase 3; 2-5A synthase 3", "tax_id": 10116, "disease": "", "pathway": " (rno:494202)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17024523", "class_list": "", "function": "Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.84", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.84", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0070106 interleukin-27-mediated signaling pathway;GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5MYT7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2Y1-1", "uniprot_id": [ { "id": "GTF2I_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2Y1", "type": "external" } ], "mass": 110215.0, "length": 979, "protein_name": "General transcription factor II-I", "gene_name": "Gtf2i", "organism": "Rat", "refseq_name": "general transcription factor II-I isoform 1", "refseq_ac": [ { "id": "NP_001001512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001512", "type": "external" } ], "gene_names_uniprotkb": "Gtf2i", "gene_names_refseq": "Gtf2ird1; Gtf2i", "protein_names_uniprotkb": "General transcription factor II-I; GTFII-I; TFII-I", "protein_names_refseq": "GTFII-I; TFII-I; general transcription factor II-I isoform 1", "tax_id": 10116, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (rno:353256)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12461526;17023658;22673903;25913238", "class_list": "", "function": "Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box (By similarity). Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observations suggest a model in which TFII-I suppresses agonist-induced calcium entry by competing with TRPC3 for binding to phospholipase C-gamma, [RefSeq, PubMed]; We identified seven novel Gtf2i transcripts with alternatively spliced 5'UTRs in the rat brain. In situ hybridization demonstrated a differential, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80SX4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0051019 mitogen-activated protein kinase binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0042995 cell projection", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0016525 negative regulation of angiogenesis;GO:0006366 transcription by RNA polymerase II;GO:0051481 negative regulation of cytosolic calcium ion concentration;GO:0014886 transition between slow and fast fiber", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5U2Y1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2A121-1", "uniprot_id": [ { "id": "FTO_RAT", "url": "https://www.uniprot.org/uniprot/Q2A121", "type": "external" } ], "mass": 57972.0, "length": 502, "protein_name": "Alpha-ketoglutarate-dependent dioxygenase FTO", "gene_name": "Fto", "organism": "Rat", "refseq_name": "alpha-ketoglutarate-dependent dioxygenase FTO", "refseq_ac": [ { "id": "NP_001034802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034802", "type": "external" } ], "gene_names_uniprotkb": "Fto", "gene_names_refseq": "Fto; RGD1305121", "protein_names_uniprotkb": "Alpha-ketoglutarate-dependent dioxygenase FTO; 1.14.11.-; 1.14.11.53; Fat mass and obesity-associated protein; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; m6A(m)-demethylase FTO; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; tRNA N1-methyl adenine demethylase FTO", "protein_names_refseq": "U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; alpha-ketoglutarate-dependent dioxygenase FTO; fat mass and obesity associated; fat mass and obesity-associated protein; m6A(m)-demethylase FTO; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; protein fto; tRNA N1-methyl adenine demethylase FTO", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); aortic valve disease 2 (Disease Ontology:DOID:0080334); traumatic brain injury (Disease Ontology:DOID:0081292); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); sciatic neuropathy (Disease Ontology:DOID:11446); cardiovascular system disease (Disease Ontology:DOID:1287); nuclear senile cataract (Disease Ontology:DOID:13963); transient cerebral ischemia (Disease Ontology:DOID:224); coronary artery disease (Disease Ontology:DOID:3393); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); abdominal aortic aneurysm (Disease Ontology:DOID:7693); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); multiple myeloma (Disease Ontology:DOID:9538); diabetic neuropathy (Disease Ontology:DOID:9743); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:291905); (R-RNO-73943)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "17143547;18218688;29393594;38092760;38129517;38165230;38340205;38376496", "class_list": "", "function": "FTO could participate in the central control of energy homeostasis., [RefSeq, PubMed]; FTO-mediated m[6]A demethylation regulates GnRH expression in the hypothalamus via the PLCbeta3/Ca[2+]/CAMK signalling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Fat mass and obesity-associated protein (FTO) affects midpalatal suture bone remodeling during rapid maxillary expansion., [RefSeq, PubMed]; N6 methyladenosine eraser FTO suppresses Staphylococcus aureus-induced ferroptosis of bone marrow mesenchymal stem cells to ameliorate osteomyelitis through regulating the MDM2/TLR4/SLC7A11 signaling pathway., [RefSeq, PubMed]; N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats. Publication Status: Online-Only, [RefSeq, PubMed]; RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA. Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping. Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Ability to repair alkylated DNA and RNA is however unsure in vivo. Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation. Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (By similarity). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "1.14.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.53", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:1990984 tRNA demethylase activity;GO:0035515 oxidative RNA demethylase activity;GO:1990931 mRNA N6-methyladenosine dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0001659 temperature homeostasis;GO:0007507 heart development;GO:0040014 regulation of multicellular organism growth;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q2A121-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2Y9-1", "uniprot_id": [ { "id": "LCA5_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2Y9", "type": "external" } ], "mass": 82610.0, "length": 727, "protein_name": "Lebercilin", "gene_name": "Lca5", "organism": "Rat", "refseq_name": "lebercilin", "refseq_ac": [ { "id": "NP_001380846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380846", "type": "external" } ], "gene_names_uniprotkb": "Lca5", "gene_names_refseq": "Lca5; RGD1308555", "protein_names_uniprotkb": "Lebercilin; Leber congenital amaurosis 5 protein homolog", "protein_names_refseq": "LCA5, lebercilin; leber congenital amaurosis 5 protein homolog; lebercilin", "tax_id": 10116, "disease": "Leber congenital amaurosis 5 (Disease Ontology:DOID:0110215); Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (rno:300866)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17546029;19800048", "class_list": "", "function": "Involved in intraflagellar transport complex-mediated outer segment protein trafficking in photoreceptor cilia. Plays a role in the ciliary transport of photoreceptors outer segment proteins., [UniProtKB, UniProtKB, UniProtKB]; Mutated OFD1 interacts with LCA5-encoded lebercilin, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5XIM2", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005929 cilium;GO:0005814 centriole;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0032391 photoreceptor connecting cilium", "go_biological_process": "GO:0015031 protein transport;GO:0045494 photoreceptor cell maintenance;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U2Y9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLM6-1", "uniprot_id": [ { "id": "P3H2_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLM6", "type": "external" } ], "mass": 79833.0, "length": 703, "protein_name": "Prolyl 3-hydroxylase 2", "gene_name": "P3h2", "organism": "Rat", "refseq_name": "prolyl 3-hydroxylase 2 precursor", "refseq_ac": [ { "id": "NP_001020798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020798", "type": "external" } ], "gene_names_uniprotkb": "P3h2; Leprel1", "gene_names_refseq": "Leprel1; P3h2", "protein_names_uniprotkb": "Prolyl 3-hydroxylase 2; 1.14.11.7; Leprecan-like protein 1", "protein_names_refseq": "leprecan-like 1; leprecan-like protein 1; prolyl 3-hydroxylase 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:288016); (R-RNO-1650814)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21757687;29393594", "class_list": "", "function": "P3H2 has preferred substrate sequences among the classes of 3Hyp sites in clade A collagen chains, [RefSeq, PubMed]; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens (PubMed:21757687). Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule (By similarity). Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that lack 4-hydroxyproline in the third position (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.7", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0019797 procollagen-proline 3-dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005604 basement membrane;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0019511 peptidyl-proline hydroxylation;GO:0032963 collagen metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KLM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B8P2-1", "uniprot_id": [ { "id": "FCRLA_RAT", "url": "https://www.uniprot.org/uniprot/Q3B8P2", "type": "external" } ], "mass": 38083.0, "length": 347, "protein_name": "Fc receptor-like A", "gene_name": "Fcrla", "organism": "Rat", "refseq_name": "Fc receptor-like A precursor", "refseq_ac": [ { "id": "NP_001094152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094152", "type": "external" } ], "gene_names_uniprotkb": "Fcrla; Fcrlm1", "gene_names_refseq": "Fcrla; Fcrlm1; RGD1306176", "protein_names_uniprotkb": "Fc receptor-like A; Fc receptor-like and mucin-like protein 1", "protein_names_refseq": "Fc receptor homolog expressed in B cells; Fc receptor-like A precursor; fc receptor-like and mucin-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:304965)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be implicated in B-cell differentiation and lymphomagenesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B8P2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI72-1", "uniprot_id": [ { "id": "IF4H_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI72", "type": "external" } ], "mass": 27324.0, "length": 248, "protein_name": "Eukaryotic translation initiation factor 4H", "gene_name": "Eif4h", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 4H", "refseq_ac": [ { "id": "NP_001006958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006958", "type": "external" } ], "gene_names_uniprotkb": "Eif4h; Wbscr1", "gene_names_refseq": "Eif4h; Wbscr1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4H; Williams-Beuren syndrome chromosomal region 1 protein homolog; eIF-4H", "protein_names_refseq": "Williams-Beuren syndrome chromosome region 1 homolog; eIF-4H; eukaryotic translation initiation factor 4H; williams-Beuren syndrome chromosomal region 1 protein homolog", "tax_id": 10116, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (rno:288599); (R-RNO-156827); (R-RNO-72649); (R-RNO-72702)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0048589 developmental growth", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI72-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62904-1", "uniprot_id": [ { "id": "DHB7_RAT", "url": "https://www.uniprot.org/uniprot/Q62904", "type": "external" } ], "mass": 37372.0, "length": 334, "protein_name": "3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7", "gene_name": "Hsd17b7", "organism": "Rat", "refseq_name": "3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7", "refseq_ac": [ { "id": "NP_058931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058931", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b7", "gene_names_refseq": "Hsd17b7", "protein_names_uniprotkb": "3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7; 1.1.1.210; 1.1.1.270; 1.1.1.62; 17-beta-HSD 7; 17-beta-hydroxysteroid dehydrogenase 7; 3-keto-steroid reductase; Dihydrotestosterone oxidoreductase; Estradiol 17-beta-dehydrogenase 7; PRAP; PRL receptor-associated protein", "protein_names_refseq": "17-beta-HSD 7; 17-beta-hydroxysteroid dehydrogenase 7; 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7; 3-keto-steroid reductase; PRAP; PRL receptor-associated protein; dihydrotestosterone oxidoreductase; estradiol 17-beta-dehydrogenase 7; hydroxysteroid dehydrogenase 17 beta, type 7; prolactin receptor-associated protein", "tax_id": 10116, "disease": "polycystic ovary syndrome (Disease Ontology:DOID:11612); steroid inherited metabolic disorder (Disease Ontology:DOID:1701)", "pathway": " (rno:29540); (R-RNO-6807047); (R-RNO-6807062)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "21454685;26873413;31587341;6946726;8663045;9658408", "class_list": "", "function": "Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:6946726, PubMed:9658408). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids (By similarity) (PubMed:9658408). Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:9658408). Converts dihydrotestosterone (DHT) to an inactive form. Also participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Stroke-prone spontaneously hypertensive rats have reduced hydroxysteroid 17-beta dehydrogenase 7 levels for low cholesterol biosynthesis., [RefSeq, PubMed]; This study showed that Effect of hyperprolactinemia on PRL-receptor expression in the prostate of long-term sexually-active rats., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" } ], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity;GO:0047024 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1990637 response to prolactin;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0021766 hippocampus development;GO:0006695 cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62904-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YDU3-1", "uniprot_id": [ { "id": "OTUD5_RAT", "url": "https://www.uniprot.org/uniprot/Q2YDU3", "type": "external" } ], "mass": 60288.0, "length": 566, "protein_name": "OTU domain-containing protein 5", "gene_name": "Otud5", "organism": "Rat", "refseq_name": "OTU domain-containing protein 5 isoform 2", "refseq_ac": [ { "id": "NP_001032585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032585", "type": "external" } ], "gene_names_uniprotkb": "Otud5", "gene_names_refseq": "Otud5", "protein_names_uniprotkb": "OTU domain-containing protein 5; 3.4.19.12; DUBA; Deubiquitinating enzyme A", "protein_names_refseq": "DUBA; OTU domain containing 5; OTU domain-containing protein 5 isoform 2; OTU domain-containing protein 5; deubiquinating enzyme A; deubiquitinating enzyme A", "tax_id": 10116, "disease": "", "pathway": " (rno:363452)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Deubiquitinating enzyme that functions as a negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1. Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0043374 CD8-positive, alpha-beta T cell differentiation;GO:0032700 negative regulation of interleukin-17 production;GO:0016579 protein deubiquitination;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2YDU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3L7M0-1", "uniprot_id": [ { "id": "GGTA1_RAT", "url": "https://www.uniprot.org/uniprot/Q3L7M0", "type": "external" } ], "mass": 43542.0, "length": 371, "protein_name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase", "gene_name": "Ggta1", "organism": "Rat", "refseq_name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1", "refseq_ac": [ { "id": "NP_663707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663707", "type": "external" } ], "gene_names_uniprotkb": "Ggta1; Ggta-1", "gene_names_refseq": "Ggta1p; Ggta1", "protein_names_uniprotkb": "N-acetyllactosaminide alpha-1,3-galactosyltransferase; 2.4.1.87; Galactosyltransferase; UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase", "protein_names_refseq": "N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform 1; N-acetyllactosaminide alpha-1,3-galactosyltransferase; UDP-galactose:beta-D-galactosyl-1, 4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase; glycoprotein galactosyltransferase alpha 1, 3; glycoprotein, alpha-galactosyltransferase 1,3", "tax_id": 10116, "disease": "", "pathway": " (rno:246766)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12626403;17206613", "class_list": "glycogene;glycosyltransferase", "function": "Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q80WF5;Q8K3Z1", "ec_number_list": [ { "id": "2.4.1.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.87", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031982 vesicle;GO:0032580 Golgi cisterna membrane;GO:0031985 Golgi cisterna", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 43, "hit_score": 0.3, "record_id": "Q3L7M0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RUG5-1", "uniprot_id": [ { "id": "ICA1L_RAT", "url": "https://www.uniprot.org/uniprot/Q6RUG5", "type": "external" } ], "mass": 48645.0, "length": 435, "protein_name": "Islet cell autoantigen 1-like protein", "gene_name": "Ica1l", "organism": "Rat", "refseq_name": "islet cell autoantigen 1-like protein", "refseq_ac": [ { "id": "NP_955432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955432", "type": "external" } ], "gene_names_uniprotkb": "Ica1l; Als2cr15", "gene_names_refseq": "Ica1l", "protein_names_uniprotkb": "Islet cell autoantigen 1-like protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog; Ica69-related protein", "protein_names_refseq": "Ica69-related protein; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog; islet cell autoantigen 1, 69kDa-like; islet cell autoantigen 1-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:316432)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12682071;22673903;26306493", "class_list": "", "function": "ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0140090 membrane curvature sensor activity", "go_cellular_component": "GO:0030667 secretory granule membrane;GO:0001669 acrosomal vesicle;GO:0005737 cytoplasm;GO:0012505 endomembrane system", "go_biological_process": "GO:0097753 membrane bending;GO:0007286 spermatid development;GO:0051046 regulation of secretion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6RUG5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5MYT9-1", "uniprot_id": [ { "id": "OASL2_RAT", "url": "https://www.uniprot.org/uniprot/Q5MYT9", "type": "external" } ], "mass": 59406.0, "length": 511, "protein_name": "2'-5'-oligoadenylate synthase-like protein 2", "gene_name": "Oasl2", "organism": "Rat", "refseq_name": "2'-5'-oligoadenylate synthase-like protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001009682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009682", "type": "external" } ], "gene_names_uniprotkb": "Oasl2", "gene_names_refseq": "Oasl2", "protein_names_uniprotkb": "2'-5'-oligoadenylate synthase-like protein 2; 2.7.7.84", "protein_names_refseq": "2'-5'-oligoadenylate synthase-like protein 2 isoform 1; 54 kDa 2'-5'-oligoadenylate synthase-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:304549)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12080145;17024523", "class_list": "", "function": "Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.84", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.84", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0001730 2'-5'-oligoadenylate synthetase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0070106 interleukin-27-mediated signaling pathway;GO:0045071 negative regulation of viral genome replication;GO:0060337 type I interferon-mediated signaling pathway;GO:0009615 response to virus;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5MYT9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63148-1", "uniprot_id": [ { "id": "CHRD_RAT", "url": "https://www.uniprot.org/uniprot/Q63148", "type": "external" } ], "mass": 102007.0, "length": 951, "protein_name": "Chordin", "gene_name": "Chrd", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Chrd", "gene_names_refseq": "", "protein_names_uniprotkb": "Chordin", "protein_names_refseq": "", "tax_id": 10116, "disease": "DiGeorge syndrome (Disease Ontology:DOID:11198); velocardiofacial syndrome (Disease Ontology:DOID:12583)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0043395 heparan sulfate proteoglycan binding;GO:0045545 syndecan binding;GO:0036122 BMP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0098793 presynapse", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0000578 embryonic axis specification;GO:0021513 spinal cord dorsal/ventral patterning;GO:0014029 neural crest formation;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q63148-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM46-1", "uniprot_id": [ { "id": "IL34_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM46", "type": "external" } ], "mass": 26772.0, "length": 234, "protein_name": "Interleukin-34", "gene_name": "Il34", "organism": "Rat", "refseq_name": "interleukin-34 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001020937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020937", "type": "external" } ], "gene_names_uniprotkb": "Il34", "gene_names_refseq": "Il34", "protein_names_uniprotkb": "Interleukin-34; IL-34", "protein_names_refseq": "IL-34; interleukin-34 isoform 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:498951); (R-RNO-449836)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "26389674;36030499", "class_list": "", "function": "Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; IL-34 deficiency impairs FOXP3(+) Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis., [RefSeq, PubMed]; In a rat cardiac allograft model, IL-34 induced transplant tolerance associated with a total inhibition of alloantibody production. Treatment of rats with IL-34 promoted allograft tolerance mediated by induction of CD8+ and CD4+ Tregs., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005157 macrophage colony-stimulating factor receptor binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043235 receptor complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006954 inflammatory response;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KM46-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62673-1", "uniprot_id": [ { "id": "PLK1_RAT", "url": "https://www.uniprot.org/uniprot/Q62673", "type": "external" } ], "mass": 68291.0, "length": 603, "protein_name": "Serine/threonine-protein kinase PLK1", "gene_name": "Plk1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase PLK1", "refseq_ac": [ { "id": "NP_058796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058796", "type": "external" } ], "gene_names_uniprotkb": "Plk1; Plk", "gene_names_refseq": "Plk1; Plk", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK1; 2.7.11.21; PLK-1; Polo-like kinase 1", "protein_names_refseq": "PLK-1; serine/threonine-protein kinase PLK1", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); urinary bladder cancer (Disease Ontology:DOID:11054); ovary epithelial cancer (Disease Ontology:DOID:2152); endometriosis (Disease Ontology:DOID:289); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (rno:25515); (R-RNO-141430); (R-RNO-141444); (R-RNO-156711); (R-RNO-162658); (R-RNO-174178); (R-RNO-176412); (R-RNO-176417); (R-RNO-2299718); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-2980767); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-5663220); (R-RNO-68877); (R-RNO-68881); (R-RNO-68884); (R-RNO-69273); (R-RNO-8852276); (R-RNO-8854518); (R-RNO-9648025)", "pathway_count": 26, "publication_count": 4, "publication_id_list": "12784254;31081105;34115550;37879229", "class_list": "", "function": "May be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during rat oocyte meiotic maturation, fertilization, and early embryonic mitosis, [RefSeq, PubMed]; MiR-593-5p promotes the development of hypoxic-induced pulmonary hypertension via targeting PLK1., [RefSeq, PubMed]; Overexpression of PLK1 relieved the myocardial ischemia-reperfusion injury of rats through inducing the mitophagy and regulating the p-AMPK/FUNDC1 axis., [RefSeq, PubMed]; Polo-like kinase 1 promotes sepsis-induced myocardial dysfunction., [RefSeq, PubMed]; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning. Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Phosphorylates CEP68 and is required for its degradation. Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope. Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock. Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression. Regulates mitotic progression by phosphorylating RIOK2. Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis. Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (By similarity). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LNH6;Q5XHX4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0045143 homologous chromosome segregation;GO:0016321 female meiosis chromosome segregation;GO:1903673 mitotic cleavage furrow formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62673-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJS7-1", "uniprot_id": [ { "id": "CPNE9_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJS7", "type": "external" } ], "mass": 61811.0, "length": 553, "protein_name": "Copine-9", "gene_name": "Cpne9", "organism": "Rat", "refseq_name": "copine-9 isoform 1", "refseq_ac": [ { "id": "NP_001020153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020153", "type": "external" } ], "gene_names_uniprotkb": "Cpne9", "gene_names_refseq": "Cpne9; RGD1309212", "protein_names_uniprotkb": "Copine-9; Copine IX", "protein_names_refseq": "copine IX; copine family member IX; copine-9 isoform 1; copine-9", "tax_id": 10116, "disease": "", "pathway": " (rno:297516)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1903861 positive regulation of dendrite extension;GO:0030154 cell differentiation;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJS7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V9H5-1", "uniprot_id": [ { "id": "P20L1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V9H5", "type": "external" } ], "mass": 114084.0, "length": 1015, "protein_name": "PHD finger protein 20-like protein 1", "gene_name": "Phf20l1", "organism": "Rat", "refseq_name": "PHD finger protein 20-like protein 1", "refseq_ac": [ { "id": "NP_001258368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258368", "type": "external" } ], "gene_names_uniprotkb": "Phf20l1", "gene_names_refseq": "Phf20l1", "protein_names_uniprotkb": "PHD finger protein 20-like protein 1", "protein_names_refseq": "PHD finger protein 20-like protein 1; tudor domain-containing protein PHF20L1", "tax_id": 10116, "disease": "", "pathway": " (rno:314964); (R-RNO-9772755)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Is a negative regulator of proteasomal degradation of a set of methylated proteins, including DNMT1 and SOX2 (By similarity). Involved in the maintainance of embryonic stem cells pluripotency, through the regulation of SOX2 levels (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140034 methylation-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0044545 NSL complex;GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0042177 negative regulation of protein catabolic process;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V9H5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62909-1", "uniprot_id": [ { "id": "KIF2C_RAT", "url": "https://www.uniprot.org/uniprot/Q62909", "type": "external" } ], "mass": 75572.0, "length": 671, "protein_name": "Kinesin-like protein KIF2C", "gene_name": "Kif2c", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Kif2c; Krp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinesin-like protein KIF2C; Kinesin-related protein 2; MCAK; Mitotic centromere-associated kinesin", "protein_names_refseq": "", "tax_id": 10116, "disease": "colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-141430); (R-RNO-141444); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-6811434); (R-RNO-68877); (R-RNO-9648025); (R-RNO-983189)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "8688559", "class_list": "", "function": "In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0051010 microtubule plus-end binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62909-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4TU93-1", "uniprot_id": [ { "id": "MRC2_RAT", "url": "https://www.uniprot.org/uniprot/Q4TU93", "type": "external" } ], "mass": 167022.0, "length": 1480, "protein_name": "C-type mannose receptor 2", "gene_name": "Mrc2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mrc2; Endo180", "gene_names_refseq": "", "protein_names_uniprotkb": "C-type mannose receptor 2; Endocytic receptor 180; Macrophage mannose receptor 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:498011); (R-RNO-1236978)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15506989;15817460", "class_list": "", "function": "May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices (By similarity). May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs) secreted by hepatic stellate cells. May mediate endocytosis of partially degraded collagens and glycoproteins produced in the extracellular matrix by MMPs., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005518 collagen binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006898 receptor-mediated endocytosis;GO:0030574 collagen catabolic process;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4TU93-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7D8-1", "uniprot_id": [ { "id": "OTULL_RAT", "url": "https://www.uniprot.org/uniprot/Q3B7D8", "type": "external" } ], "mass": 41793.0, "length": 353, "protein_name": "Inactive ubiquitin thioesterase OTULINL", "gene_name": "Otulinl", "organism": "Rat", "refseq_name": "inactive ubiquitin thioesterase OTULINL", "refseq_ac": [ { "id": "NP_001032737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032737", "type": "external" } ], "gene_names_uniprotkb": "Otulinl; Fam105a", "gene_names_refseq": "Fam105a; Otulinl", "protein_names_uniprotkb": "Inactive ubiquitin thioesterase OTULINL", "protein_names_refseq": "family with sequence similarity 105, member A; inactive ubiquitin thioesterase FAM105A; inactive ubiquitin thioesterase OTULINL; protein FAM105A", "tax_id": 10116, "disease": "", "pathway": " (rno:310190)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Lacks deubiquitinase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:1990108 protein linear deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3B7D8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9F5-1", "uniprot_id": [ { "id": "DPH6_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9F5", "type": "external" } ], "mass": 29984.0, "length": 267, "protein_name": "Diphthine--ammonia ligase", "gene_name": "Dph6", "organism": "Rat", "refseq_name": "diphthine--ammonia ligase", "refseq_ac": [ { "id": "NP_001014203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014203", "type": "external" } ], "gene_names_uniprotkb": "Dph6; Atpbd4", "gene_names_refseq": "Atpbd4; Dph6; RGD1310006", "protein_names_uniprotkb": "Diphthine--ammonia ligase; 6.3.1.14; ATP-binding domain-containing protein 4; Diphthamide synthase; Diphthamide synthetase; Protein DPH6 homolog", "protein_names_refseq": "ATP binding domain 4; ATP-binding domain-containing protein 4; diphthamide synthase; diphthamide synthetase; diphthine--ammonia ligase; protein DPH6 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:362191); (R-RNO-5358493)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (EEF2) to diphthamide (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "6.3.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.14", "type": "external" } ], "go_molecular_function": "GO:0017178 diphthine-ammonia ligase activity;GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M9F5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q65Z14-1", "uniprot_id": [ { "id": "OSMR_RAT", "url": "https://www.uniprot.org/uniprot/Q65Z14", "type": "external" } ], "mass": 108625.0, "length": 962, "protein_name": "Oncostatin-M-specific receptor subunit beta", "gene_name": "Osmr", "organism": "Rat", "refseq_name": "oncostatin-M-specific receptor subunit beta precursor", "refseq_ac": [ { "id": "NP_001005384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005384", "type": "external" } ], "gene_names_uniprotkb": "Osmr; Osmrb", "gene_names_refseq": "Osmr", "protein_names_uniprotkb": "Oncostatin-M-specific receptor subunit beta; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; Interleukin-31 receptor subunit beta; OSM-R; OSM-specific receptor", "protein_names_refseq": "IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; interleukin-31 receptor subunit beta; oncostatin M specific receptor; oncostatin-M-specific receptor subunit beta precursor; oncostatin-M-specific receptor subunit beta", "tax_id": 10116, "disease": "primary localized cutaneous amyloidosis 1 (Disease Ontology:DOID:0080930)", "pathway": " (rno:310132); (R-RNO-6788467)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15743783", "class_list": "", "function": "Functions as a shared membrane-bound signal-transducing subunit in two distinct receptor complexes, the type II OSM receptor (heterodimer composed of OSMR and IL6ST) and the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which respectively bind OSM and IL31 (By similarity). Functionally, OSM signaling via OSMR/IL6ST regulates many processes including cell proliferation, cell differentiation, cytokine production, whereas the IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (PubMed:15743783). Mechanistically, in both the OSM-IL6ST/gp130-OSMR and IL31-IL31RA-OSMR complexes, receptor dimerization activates JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL6ST/gp130 and OSMR (or IL31RA and OSMR) (By similarity). These kinases phosphorylate tyrosine residues on IL6ST/gp130 and OSMR (or IL31RA and OSMR), creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated (By similarity). In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019838 growth factor binding;GO:0019955 cytokine binding;GO:0004924 oncostatin-M receptor activity;GO:0004896 cytokine receptor activity;GO:0005127 ciliary neurotrophic factor receptor binding", "go_cellular_component": "GO:0005900 oncostatin-M receptor complex;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0038165 oncostatin-M-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0034097 response to cytokine;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q65Z14-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63598-1", "uniprot_id": [ { "id": "PLST_RAT", "url": "https://www.uniprot.org/uniprot/Q63598", "type": "external" } ], "mass": 70680.0, "length": 630, "protein_name": "Plastin-3", "gene_name": "Pls3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pls3", "gene_names_refseq": "", "protein_names_uniprotkb": "Plastin-3; T-plastin", "protein_names_refseq": "", "tax_id": 10116, "disease": "osteoporosis (Disease Ontology:DOID:11476); Huntington's disease (Disease Ontology:DOID:12858); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (rno:81748)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Actin-bundling protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0098699 structural constituent of presynaptic actin cytoskeleton", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0031594 neuromuscular junction;GO:0032432 actin filament bundle", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0051017 actin filament bundle assembly;GO:0060348 bone development;GO:0051639 actin filament network formation;GO:0098693 regulation of synaptic vesicle cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63598-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q629-1", "uniprot_id": [ { "id": "DPP10_RAT", "url": "https://www.uniprot.org/uniprot/Q6Q629", "type": "external" } ], "mass": 90891.0, "length": 796, "protein_name": "Inactive dipeptidyl peptidase 10", "gene_name": "Dpp10", "organism": "Rat", "refseq_name": "inactive dipeptidyl peptidase 10 isoform 3", "refseq_ac": [ { "id": "NP_001012205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012205", "type": "external" } ], "gene_names_uniprotkb": "Dpp10", "gene_names_refseq": "DPP X; DPPY; Dpp10", "protein_names_uniprotkb": "Inactive dipeptidyl peptidase 10; DPP X; Dipeptidyl peptidase X; Kv4 potassium channel auxiliary subunit", "protein_names_refseq": "Kv4 potassium channel auxiliary subunit; dipeptidyl peptidase X; dipeptidylpeptidase 10; inactive dipeptidyl peptidase 10 isoform 3; inactive dipeptidyl peptidase 10", "tax_id": 10116, "disease": "asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:363972)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10.1039/D0MO00044B;15671030;16123112;19901547;24090084;25355692;34106099;38843836", "class_list": "", "function": "DPP10 modulates Kv4.2-mediated A-type potassium channels, [RefSeq, PubMed]; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:16123112, PubMed:19901547). Has no dipeptidyl aminopeptidase activity (Probable)., [UniProtKB, PubMed, UniProtKB, PubMed]; Results show colocalization of DPP10 with Kv4 and KChIP at the plasma membrane of subthreshold A-type K+ current expressing neuron somata supports the existence of Kv4/KChIP/DPPL ternary complex in vivo, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 2, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0006508 proteolysis;GO:0072659 protein localization to plasma membrane;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q6Q629-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62600-1", "uniprot_id": [ { "id": "NOS3_RAT", "url": "https://www.uniprot.org/uniprot/Q62600", "type": "external" } ], "mass": 133290.0, "length": 1202, "protein_name": "Nitric oxide synthase 3", "gene_name": "Nos3", "organism": "Rat", "refseq_name": "nitric oxide synthase 3", "refseq_ac": [ { "id": "NP_068610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068610", "type": "external" } ], "gene_names_uniprotkb": "Nos3", "gene_names_refseq": "Nos3; eNos", "protein_names_uniprotkb": "Nitric oxide synthase 3; 1.14.13.39; Constitutive NOS; EC-NOS; Endothelial NOS; NOS type III; NOSIII; Nitric oxide synthase, endothelial; cNOS; eNOS", "protein_names_refseq": "EC-NOS; NOS type III; NOSIII; cNOS; constitutive NOS; endothelial NOS; endothelial nitric oxide synthase 3; nitric oxide synthase 3, endothelial cell; nitric oxide synthase 3; nitric oxide synthase, endothelial", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); cardiomyopathy (Disease Ontology:DOID:0050700); obstructive sleep apnea (Disease Ontology:DOID:0050848); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); respiratory allergy (Disease Ontology:DOID:0060496); polycystic kidney disease (Disease Ontology:DOID:0080322); osteonecrosis (Disease Ontology:DOID:10159); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); renal hypertension (Disease Ontology:DOID:1073); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); essential hypertension (Disease Ontology:DOID:10825); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sickle cell anemia (Disease Ontology:DOID:10923); intracranial aneurysm (Disease Ontology:DOID:10941); nephritis (Disease Ontology:DOID:10952); urinary bladder cancer (Disease Ontology:DOID:11054); pulmonary edema (Disease Ontology:DOID:11396); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); primary biliary cholangitis (Disease Ontology:DOID:12236); vulva cancer (Disease Ontology:DOID:1245); leiomyoma (Disease Ontology:DOID:127); telangiectasis (Disease Ontology:DOID:1272); retinopathy of prematurity (Disease Ontology:DOID:13025); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); Behcet's disease (Disease Ontology:DOID:13241); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); bladder neck obstruction (Disease Ontology:DOID:13948); hypothyroidism (Disease Ontology:DOID:1459); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); breast cancer (Disease Ontology:DOID:1612); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); endometrial carcinoma (Disease Ontology:DOID:2871); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); coronary artery disease (Disease Ontology:DOID:3393); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); macular retinal edema (Disease Ontology:DOID:4449); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); aortic valve disease (Disease Ontology:DOID:62); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); overnutrition (Disease Ontology:DOID:654); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); ileus (Disease Ontology:DOID:8440); retinal degeneration (Disease Ontology:DOID:8466); lung disease (Disease Ontology:DOID:850); vasculitis (Disease Ontology:DOID:865); diabetic retinopathy (Disease Ontology:DOID:8947); hepatopulmonary syndrome (Disease Ontology:DOID:900); acute myeloid leukemia (Disease Ontology:DOID:9119); central sleep apnea (Disease Ontology:DOID:9220); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); irritable bowel syndrome (Disease Ontology:DOID:9778); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24600); (R-RNO-1222556); (R-RNO-1474151); (R-RNO-203615); (R-RNO-203641); (R-RNO-203754); (R-RNO-392154); (R-RNO-5218920); (R-RNO-9009391); (R-RNO-9856530)", "pathway_count": 10, "publication_count": 17, "publication_id_list": "10025949;15105416;15808839;16085713;17574745;19139380;22673903;22977010;28223727;28844813;36513147;37222247;37815888;39178948;39240727;7527874;7537461", "class_list": "", "function": "Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca[2+] and NO signals., [RefSeq, PubMed]; Immunoglobulin-Mediated Cardiac Protection From Ischemia/Reperfusion Injury in Diabetic Rats Is Associated With Endothelial Nitric Oxide Synthase/Glucose Transporter-4 Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Methylation of eNOS in the rat penile corpus cavernosum under different pathological states and its relationship with erectile function., [RefSeq, PubMed]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions., [UniProtKB, UniProtKB, UniProtKB]; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets., [UniProtKB, UniProtKB]; Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling. Erratum:[Aging (Albany NY). 2023 Dec 29;15(24):15703-15704. doi: 10.18632/aging.205458. PMID: 38157439], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 80, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O88672;O89041;Q62734;Q68GV6;Q75NE4", "ec_number_list": [ { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0034617 tetrahydrobiopterin binding;GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0003057 regulation of the force of heart contraction by chemical signal;GO:0046209 nitric oxide metabolic process;GO:0014740 negative regulation of muscle hyperplasia;GO:0014806 smooth muscle hyperplasia;GO:1903576 response to L-arginine", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q62600-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6W5G4-1", "uniprot_id": [ { "id": "PLPR2_RAT", "url": "https://www.uniprot.org/uniprot/Q6W5G4", "type": "external" } ], "mass": 36936.0, "length": 343, "protein_name": "Phospholipid phosphatase-related protein type 2", "gene_name": "Plppr2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Plppr2; Lppr2; Prg4", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 2; Inactive phospholipid phosphatase PLPPR2; Lipid phosphate phosphatase-related protein type 2; PRG-4; Plasticity-related gene 4 protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:300443); (R-RNO-419408)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14750979;22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6W5G4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64562-1", "uniprot_id": [ { "id": "CP21A_RAT", "url": "https://www.uniprot.org/uniprot/Q64562", "type": "external" } ], "mass": 55946.0, "length": 493, "protein_name": "Steroid 21-hydroxylase", "gene_name": "Cyp21a1; Cyp21", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cyp21a1; Cyp21; Cyp21a1", "gene_names_refseq": "", "protein_names_uniprotkb": "Steroid 21-hydroxylase; 1.14.14.16; 21-OHase; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 XXI; Cytochrome P450-C21", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital adrenal hyperplasia (Disease Ontology:DOID:0050811)", "pathway": " (rno:24298); (R-RNO-193993); (R-RNO-194002); (R-RNO-211976)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9408081", "class_list": "", "function": "A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.16", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.16", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0005496 steroid binding;GO:0020037 heme binding;GO:0004509 steroid 21-monooxygenase activity;GO:0103069 17-hydroxyprogesterone 21-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006700 C21-steroid hormone biosynthetic process;GO:0006704 glucocorticoid biosynthetic process;GO:0006705 mineralocorticoid biosynthetic process;GO:0071375 cellular response to peptide hormone stimulus;GO:0042448 progesterone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64562-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q60GF7-1", "uniprot_id": [ { "id": "PIGX_RAT", "url": "https://www.uniprot.org/uniprot/Q60GF7", "type": "external" } ], "mass": 28423.0, "length": 252, "protein_name": "GPI alpha-1,4-mannosyltransferase I, stabilizing subunit", "gene_name": "Pigx", "organism": "Rat", "refseq_name": "GPI alpha-1,4-mannosyltransferase I, stabilizing subunit precursor", "refseq_ac": [ { "id": "NP_001094121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094121", "type": "external" } ], "gene_names_uniprotkb": "Pigx", "gene_names_refseq": "Pigx; RGD1307289", "protein_names_uniprotkb": "GPI alpha-1,4-mannosyltransferase I, stabilizing subunit; PIG-X; Phosphatidylinositol-glycan biosynthesis class X protein", "protein_names_refseq": "GPI alpha-1,4-mannosyltransferase I, stabilizing subunit precursor; GPI alpha-1,4-mannosyltransferase I, stabilizing subunit; GPI-mannosyltransferase subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:288041); (R-RNO-162710)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15635094", "class_list": "", "function": "A non-AUG translation initiation site (CUG) is used in rat Pigx, [RefSeq, PubMed]; Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis (PubMed:15635094). Probably acts by stabilizing the mannosyltransferase PIGM (PubMed:15635094)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a type I transmembrane protein in the endoplasmic reticulum (ER). The protein is an essential component of glycosylphosphatidylinositol-mannosyltransferase I, which transfers the first of the four mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. The protein is translated from a non-AUG translation initiation site. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1990529 glycosylphosphatidylinositol-mannosyltransferase I complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q60GF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63366-1", "uniprot_id": [ { "id": "NXPH1_RAT", "url": "https://www.uniprot.org/uniprot/Q63366", "type": "external" } ], "mass": 31017.0, "length": 271, "protein_name": "Neurexophilin-1", "gene_name": "Nxph1", "organism": "Rat", "refseq_name": "neurexophilin-1 precursor", "refseq_ac": [ { "id": "NP_037126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037126", "type": "external" } ], "gene_names_uniprotkb": "Nxph1; Nph1", "gene_names_refseq": "Nxph1", "protein_names_uniprotkb": "Neurexophilin-1; Neurophilin", "protein_names_refseq": "neurexophilin-1 precursor; neurophilin", "tax_id": 10116, "disease": "Doyne honeycomb retinal dystrophy (Disease Ontology:DOID:0060745); high grade glioma (Disease Ontology:DOID:3070); cutis laxa (Disease Ontology:DOID:3144); macular degeneration (Disease Ontology:DOID:4448); adenoma (Disease Ontology:DOID:657); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (rno:25501)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12141453;25157101;25420124;8699246", "class_list": "", "function": "Dystroglycan binding to alpha-neurexin competes with neurexophilin-1 and neuroligin in the brain., [RefSeq, PubMed]; May be signaling molecules that resemble neuropeptides., [UniProtKB, UniProtKB]; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity)., [UniProtKB]; NRXN1alpha KO rats were found to present with large and persistent nonsocial deficits, including hyperactivity, deficits in simple instrumental learning, latent inhibition, and spatial-dependent learning., [RefSeq, PubMed]; Study on the expression of NXPH1 in the developing and adult olfactory bulb, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q3KRD4", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0043083 synaptic cleft;GO:0005576 extracellular region", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63366-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6ED65-1", "uniprot_id": [ { "id": "EMAL5_RAT", "url": "https://www.uniprot.org/uniprot/Q6ED65", "type": "external" } ], "mass": 219808.0, "length": 1977, "protein_name": "Echinoderm microtubule-associated protein-like 5", "gene_name": "Eml5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Eml5", "gene_names_refseq": "", "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 5; EMAP-5; EMAP-like protein 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723)", "pathway": " (rno:444982)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15225882", "class_list": "", "function": "May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6ED65-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7D4-1", "uniprot_id": [ { "id": "CP20A_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7D4", "type": "external" } ], "mass": 51998.0, "length": 462, "protein_name": "Cytochrome P450 20A1", "gene_name": "Cyp20a1", "organism": "Rat", "refseq_name": "cytochrome P450 20A1", "refseq_ac": [ { "id": "NP_955433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955433", "type": "external" } ], "gene_names_uniprotkb": "Cyp20a1", "gene_names_refseq": "Cyp20a1", "protein_names_uniprotkb": "Cytochrome P450 20A1; 1.14.-.-", "protein_names_refseq": "cytochrome P450 20A1", "tax_id": 10116, "disease": "", "pathway": " (rno:316435)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P7D4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM47-1", "uniprot_id": [ { "id": "CDK10_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM47", "type": "external" } ], "mass": 40634.0, "length": 358, "protein_name": "Cyclin-dependent kinase 10", "gene_name": "Cdk10", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 10 isoform 3", "refseq_ac": [ { "id": "NP_001020893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020893", "type": "external" } ], "gene_names_uniprotkb": "Cdk10", "gene_names_refseq": "Cdk10", "protein_names_uniprotkb": "Cyclin-dependent kinase 10; 2.7.11.22; Cell division protein kinase 10", "protein_names_refseq": "cell division protein kinase 10; cyclin-dependent kinase (CDC2-like) 10; cyclin-dependent kinase 10 isoform 3", "tax_id": 10116, "disease": "", "pathway": " (rno:361434)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0097472 cyclin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0036064 ciliary basal body;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0032956 regulation of actin cytoskeleton organization;GO:0043410 positive regulation of MAPK cascade;GO:0000086 G2/M transition of mitotic cell cycle;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KM47-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64583-1", "uniprot_id": [ { "id": "CP2BF_RAT", "url": "https://www.uniprot.org/uniprot/Q64583", "type": "external" } ], "mass": 56320.0, "length": 495, "protein_name": "Cytochrome P450 2B15", "gene_name": "Cyp2b15", "organism": "Rat", "refseq_name": "cytochrome P450 2B15", "refseq_ac": [ { "id": "NP_001129140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129140", "type": "external" } ], "gene_names_uniprotkb": "Cyp2b15; LOC100911763", "gene_names_refseq": "Cyp2b15", "protein_names_uniprotkb": "Cytochrome P450 2B15; 1.14.14.1; CYPIIB15", "protein_names_refseq": "CYPIIB15; cytochrome P-450b type b; cytochrome P450 2B15", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); tuberculosis (Disease Ontology:DOID:399); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acute myeloid leukemia (Disease Ontology:DOID:9119); neonatal abstinence syndrome (Disease Ontology:DOID:9828); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:685222)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8294026", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64583-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3MID2-1", "uniprot_id": [ { "id": "CP4F3_RAT", "url": "https://www.uniprot.org/uniprot/Q3MID2", "type": "external" } ], "mass": 59906.0, "length": 524, "protein_name": "Cytochrome P450 4F3", "gene_name": "Cyp4f18; Cyp4f3", "organism": "Rat", "refseq_name": "cytochrome P450 4F3", "refseq_ac": [ { "id": "NP_001028858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028858", "type": "external" } ], "gene_names_uniprotkb": "Cyp4f18; Cyp4f3; Cyp4f18", "gene_names_refseq": "CYPIVF3; Cyp4f18; Cyp4f3", "protein_names_uniprotkb": "Cytochrome P450 4F3; CYPIVF3; Leukotriene-B(4) omega-1/omega-2 hydroxylase", "protein_names_refseq": "cytochrome P450 4F3; cytochrome P450-LTB-omega; leukotriene-B(4) 20-monooxygenase 2; leukotriene-B(4) omega-1/omega-2 hydroxylase; leukotriene-B(4) omega-hydroxylase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:290623); (R-RNO-211935); (R-RNO-211958); (R-RNO-211979); (R-RNO-2142691); (R-RNO-2142816)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of the pro-inflammatory lipid mediator leukotriene B4 (LTB4). Hydroxylates at the omega-1 and omega-2 positions LTB4. This oxidation step leads to LTB4 inactivation, which is postulated to be a crucial part of the resolution of inflammation. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0050051 leukotriene-B4 20-monooxygenase activity;GO:0097258 20-hydroxy-leukotriene B4 omega oxidase activity;GO:0097259 20-aldehyde-leukotriene B4 20-monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097267 omega-hydroxylase P450 pathway;GO:0010430 fatty acid omega-oxidation;GO:0019369 arachidonate metabolic process;GO:0036101 leukotriene B4 catabolic process;GO:2001304 lipoxin B4 metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3MID2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYF5-1", "uniprot_id": [ { "id": "DTWD1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYF5", "type": "external" } ], "mass": 34903.0, "length": 304, "protein_name": "tRNA-uridine aminocarboxypropyltransferase 1", "gene_name": "Dtwd1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dtwd1", "gene_names_refseq": "", "protein_names_uniprotkb": "tRNA-uridine aminocarboxypropyltransferase 1; 2.5.1.25; DTW domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:296119)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20))., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.25", "type": "external" } ], "go_molecular_function": "GO:0016432 tRNA-uridine aminocarboxypropyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006400 tRNA modification;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYF5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64159-1", "uniprot_id": [ { "id": "CD3G_RAT", "url": "https://www.uniprot.org/uniprot/Q64159", "type": "external" } ], "mass": 20545.0, "length": 182, "protein_name": "T-cell surface glycoprotein CD3 gamma chain", "gene_name": "Cd3g", "organism": "Rat", "refseq_name": "T-cell surface glycoprotein CD3 gamma chain precursor", "refseq_ac": [ { "id": "NP_001071114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071114", "type": "external" } ], "gene_names_uniprotkb": "Cd3g", "gene_names_refseq": "Cd3g", "protein_names_uniprotkb": "T-cell surface glycoprotein CD3 gamma chain; T-cell receptor T3 gamma chain", "protein_names_refseq": "CD3 antigen, gamma polypeptide; CD3 gamma-chain; CD3 molecule, gamma polypeptide; CD3g molecule; T-cell receptor T3 gamma chain; T-cell surface glycoprotein CD3 gamma chain precursor; T-cell surface glycoprotein CD3 gamma chain", "tax_id": 10116, "disease": "immunodeficiency 17 (Disease Ontology:DOID:0111973)", "pathway": " (rno:300678); (R-RNO-198933); (R-RNO-202424); (R-RNO-202427); (R-RNO-202430); (R-RNO-202433); (R-RNO-2029481); (R-RNO-2029482); (R-RNO-2029485); (R-RNO-389948); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 12, "publication_count": 1, "publication_id_list": "1531205", "class_list": "", "function": "Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0032395 MHC class II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0042105 alpha-beta T cell receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0015031 protein transport;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64159-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLH3-1", "uniprot_id": [ { "id": "OGRL1_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLH3", "type": "external" } ], "mass": 52821.0, "length": 465, "protein_name": "Opioid growth factor receptor-like protein 1", "gene_name": "Ogfrl1", "organism": "Rat", "refseq_name": "opioid growth factor receptor-like protein 1", "refseq_ac": [ { "id": "NP_001020879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020879", "type": "external" } ], "gene_names_uniprotkb": "Ogfrl1", "gene_names_refseq": "Ogfrl1", "protein_names_uniprotkb": "Opioid growth factor receptor-like protein 1", "protein_names_refseq": "opioid growth factor receptor-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:316290)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140625 opioid growth factor receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLH3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FB95-1", "uniprot_id": [ { "id": "LMA1L_RAT", "url": "https://www.uniprot.org/uniprot/Q5FB95", "type": "external" } ], "mass": 56321.0, "length": 503, "protein_name": "Protein ERGIC-53-like", "gene_name": "Lman1l", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lman1l; Ergl", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein ERGIC-53-like; ERGIC53-like protein; LMAN1-like protein; Lectin mannose-binding 1-like; Slamp; Sublingual acinar membrane protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:300743); (R-RNO-204005); (R-RNO-5694530)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15923361", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005537 D-mannose binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FB95-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62818-1", "uniprot_id": [ { "id": "EI2BB_RAT", "url": "https://www.uniprot.org/uniprot/Q62818", "type": "external" } ], "mass": 38875.0, "length": 351, "protein_name": "Translation initiation factor eIF2B subunit beta", "gene_name": "Eif2b2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Eif2b2; Eif2bb", "gene_names_refseq": "", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit beta; eIF2B GDP-GTP exchange factor subunit beta", "protein_names_refseq": "", "tax_id": 10116, "disease": "leukoencephalopathy with vanishing white matter (Disease Ontology:DOID:0060868); leukoencephalopathy with vanishing white matter 2 (Disease Ontology:DOID:0070373)", "pathway": " (R-RNO-72731)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8929216;9139680", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08956", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0030424 axon;GO:0098794 postsynapse", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0021766 hippocampus development;GO:0042552 myelination;GO:0050852 T cell receptor signaling pathway;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62818-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MGD0-1", "uniprot_id": [ { "id": "CUTA_RAT", "url": "https://www.uniprot.org/uniprot/Q6MGD0", "type": "external" } ], "mass": 18659.0, "length": 177, "protein_name": "Protein CutA", "gene_name": "Cuta", "organism": "Rat", "refseq_name": "protein CutA isoform 2", "refseq_ac": [ { "id": "NP_001158178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158178", "type": "external" } ], "gene_names_uniprotkb": "Cuta", "gene_names_refseq": "CutA1; Cuta", "protein_names_uniprotkb": "Protein CutA; Brain acetylcholinesterase putative membrane anchor", "protein_names_refseq": "brain acetylcholinesterase putative membrane anchor; divalent cation tolerant protein CUTA; protein CutA isoform 2; protein CutA", "tax_id": 10116, "disease": "", "pathway": " (rno:294288)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10954708;12949080;15060004;19049969", "class_list": "", "function": "Comparative x-ray crystallography analysis suggests CutA1 proteins have a role in signal transduction through allosteric communications between subunits., [RefSeq, PubMed]; May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE)., [UniProtKB]; Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0010038 response to metal ion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6MGD0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IRI9-1", "uniprot_id": [ { "id": "FMO2_RAT", "url": "https://www.uniprot.org/uniprot/Q6IRI9", "type": "external" } ], "mass": 60899.0, "length": 535, "protein_name": "Dimethylaniline monooxygenase [N-oxide-forming] 2", "gene_name": "Fmo2", "organism": "Rat", "refseq_name": "dimethylaniline monooxygenase [N-oxide-forming] 2", "refseq_ac": [ { "id": "NP_653338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653338", "type": "external" } ], "gene_names_uniprotkb": "Fmo2", "gene_names_refseq": "Fmo2", "protein_names_uniprotkb": "Dimethylaniline monooxygenase [N-oxide-forming] 2; 1.14.13.-; Dimethylaniline oxidase 2; FMO 2; Pulmonary flavin-containing monooxygenase 2", "protein_names_refseq": "FMO 2; dimethylaniline monooxygenase [N-oxide-forming] 2; dimethylaniline oxidase 2; flavin containing monooxygenase 2; pulmonary flavin-containing monooxygenase 2", "tax_id": 10116, "disease": "chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411)", "pathway": " (rno:246245); (R-RNO-217271)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15454729", "class_list": "", "function": "Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation., [UniProtKB, UniProtKB]; FMO2 genetic polymorphism was associated with major differences in the S-oxidative metabolism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0050661 NADP binding;GO:0004497 monooxygenase activity;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0046322 negative regulation of fatty acid oxidation;GO:0097009 energy homeostasis;GO:0006805 xenobiotic metabolic process;GO:0009404 toxin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IRI9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63652-1", "uniprot_id": [ { "id": "OPSB_RAT", "url": "https://www.uniprot.org/uniprot/Q63652", "type": "external" } ], "mass": 39062.0, "length": 346, "protein_name": "Short-wave-sensitive opsin 1", "gene_name": "Opn1sw", "organism": "Rat", "refseq_name": "short-wave-sensitive opsin 1", "refseq_ac": [ { "id": "NP_112277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112277", "type": "external" } ], "gene_names_uniprotkb": "Opn1sw; Bcp", "gene_names_refseq": "Opn1sw", "protein_names_uniprotkb": "Short-wave-sensitive opsin 1; BOP; Blue cone photoreceptor pigment; Blue-sensitive opsin; S opsin; Short wavelength-sensitive cone opsin", "protein_names_refseq": "BOP; blue cone opsin-like pigment; blue cone photoreceptor pigment; blue-sensitive opsin; opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan); s opsin; short wavelength-sensitive cone opsin; short-wave-sensitive opsin 1", "tax_id": 10116, "disease": "blue color blindness (Disease Ontology:DOID:11661)", "pathway": " (rno:81644); (R-RNO-2187335); (R-RNO-418594); (R-RNO-419771)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9147475", "class_list": "", "function": "G protein-coupled photoreceptor that selectively activates G(i) proteins in response to short-wavelength (blue-violet) light, thereby decreasing intracellular cAMP levels. Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of cone photoreceptor function. Involved in ensuring the correct abundance and localization of retinal membrane proteins (By similarity). Mediates visual perception of blue light (By similarity). May contribute to increased spectral sensitivity under dim light conditions (By similarity). Is not UV-sensitive (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors. Involved in ensuring correct abundance and localization of retinal membrane proteins. May increase spectral sensitivity in dim light., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O70363", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0004930 G protein-coupled receptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043195 terminal bouton;GO:0048471 perinuclear region of cytoplasm;GO:0044297 cell body;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071492 cellular response to UV-A", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63652-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63503-1", "uniprot_id": [ { "id": "NR1D1_RAT", "url": "https://www.uniprot.org/uniprot/Q63503", "type": "external" } ], "mass": 66693.0, "length": 615, "protein_name": "Nuclear receptor subfamily 1 group D member 1", "gene_name": "Nr1d1", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 1 group D member 1 isoform 2", "refseq_ac": [ { "id": "NP_665718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665718", "type": "external" } ], "gene_names_uniprotkb": "Nr1d1", "gene_names_refseq": "Nr1d1; REV-ERBAALPHA", "protein_names_uniprotkb": "Nuclear receptor subfamily 1 group D member 1; EAR-1; Rev-erbA-alpha; V-erbA-related protein 1", "protein_names_refseq": "V-erbA-related protein 1; V-erbA-related protein EAR-1; nuclear receptor subfamily 1 group D member 1 isoform 2; rev-erb alpha; rev-erbA-alpha", "tax_id": 10116, "disease": "brain small vessel disease (Disease Ontology:DOID:0112313); portal hypertension (Disease Ontology:DOID:10762); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); hypothyroidism (Disease Ontology:DOID:1459); hyperthyroidism (Disease Ontology:DOID:7998); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:252917); (R-RNO-383280)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "21874017;22425774;22549838;22673903;2542765;31957097;36077427;38279698;38324049", "class_list": "", "function": "Central administration of REV-ERBalpha agonist promotes opposite responses on energy balance in fasted and fed states., [RefSeq, PubMed]; PTZ-kindled rat model; evaluation of seizure, hippocampal EGR-1, and Rev-erbalpha gene regulation, behavioral analysis, and antioxidant capacity of Gum Arabic. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging. Publication Status: Online-Only, [RefSeq, PubMed]; Rev-erbalpha attenuates refractory periapical periodontitis via M1 polarization: An in vitro and in vivo study., [RefSeq, PubMed]; This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator (By similarity). In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis (PubMed:22425774). In collaboration with SP1, activates GJA1 transcription in a heme-independent manner (By similarity). Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6S7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043197 dendritic spine", "go_biological_process": "GO:1903979 negative regulation of microglial cell activation;GO:0060086 circadian temperature homeostasis;GO:0070859 positive regulation of bile acid biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q63503-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62767-1", "uniprot_id": [ { "id": "DUS4_RAT", "url": "https://www.uniprot.org/uniprot/Q62767", "type": "external" } ], "mass": 43187.0, "length": 395, "protein_name": "Dual specificity protein phosphatase 4", "gene_name": "Dusp4", "organism": "Rat", "refseq_name": "dual specificity protein phosphatase 4", "refseq_ac": [ { "id": "NP_071535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071535", "type": "external" } ], "gene_names_uniprotkb": "Dusp4; Mkp2", "gene_names_refseq": "Dusp4; Mkp-2; Mkp2", "protein_names_uniprotkb": "Dual specificity protein phosphatase 4; 3.1.3.16; 3.1.3.48; MAP kinase phosphatase 2; MKP-2; Mitogen-activated protein kinase phosphatase 2", "protein_names_refseq": "MAP kinase phosphatase 2; dual specificity protein phosphatase 4; mitogen-activated protein kinase phosphatase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:60587); (R-RNO-112409); (R-RNO-202670); (R-RNO-5675221)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "12865160;16849326;24973647;32959171;7782322", "class_list": "", "function": "DUSP4 gene knockdown further supports the hypothesis that DUSP4 is an antioxidant gene, critical in the modulation of eNOS expression, and thus protects against Cd(2+)-induced stress., [RefSeq, PubMed]; Dual Specificity Phosphatases Support Axon Plasticity and Viability., [RefSeq, PubMed]; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The I(1)-imidazoline receptor in PC12 pheochromocytoma cells induces MKP-2 phosphatase., [RefSeq, PubMed]; The inhibition of hepatic gluconeogenesis by AMPK may, in part, be mediated by an immediate early gene response involving EGR1 and its target, DUSP4, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:1990439 MAP kinase serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0016311 dephosphorylation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0006470 protein dephosphorylation;GO:0001706 endoderm formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62767-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52RG8-1", "uniprot_id": [ { "id": "FRS3_RAT", "url": "https://www.uniprot.org/uniprot/Q52RG8", "type": "external" } ], "mass": 54347.0, "length": 492, "protein_name": "Fibroblast growth factor receptor substrate 3", "gene_name": "Frs3", "organism": "Rat", "refseq_name": "fibroblast growth factor receptor substrate 3", "refseq_ac": [ { "id": "NP_001017382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017382", "type": "external" } ], "gene_names_uniprotkb": "Frs3; Snt2", "gene_names_refseq": "Frs3", "protein_names_uniprotkb": "Fibroblast growth factor receptor substrate 3; FGFR substrate 3; FGFR-signaling adaptor SNT2; SNT-2; Suc1-associated neurotrophic factor target 2", "protein_names_refseq": "FGFR substrate 3; FGFR-signaling adaptor SNT2; SNT-2; fibroblast growth factor receptor substrate 3; suc1-associated neurotrophic factor target 2", "tax_id": 10116, "disease": "", "pathway": " (rno:316213); (R-RNO-5654693); (R-RNO-5654700); (R-RNO-5654706); (R-RNO-5654712); (R-RNO-5673001); (R-RNO-9696270); (R-RNO-9696273)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q52RG8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62929-1", "uniprot_id": [ { "id": "ILRL2_RAT", "url": "https://www.uniprot.org/uniprot/Q62929", "type": "external" } ], "mass": 64142.0, "length": 561, "protein_name": "Interleukin-1 receptor-like 2", "gene_name": "Il1rl2", "organism": "Rat", "refseq_name": "interleukin-1 receptor-like 2 precursor", "refseq_ac": [ { "id": "NP_598259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598259", "type": "external" } ], "gene_names_uniprotkb": "Il1rl2", "gene_names_refseq": "Il1rl2", "protein_names_uniprotkb": "Interleukin-1 receptor-like 2; 3.2.2.6; IL-1Rrp2; IL-36 receptor; IL1R-rp2; Interleukin-1 receptor-related protein 2", "protein_names_refseq": "IL-1Rrp2; IL-36 receptor; IL1R-rp2; interleukin-1 receptor-like 2 precursor; interleukin-1 receptor-related protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:171106); (R-RNO-9007892); (R-RNO-9014826)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "32048631;8898719", "class_list": "", "function": "Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. Receptor for the interleukin IL36G. Binding to the agonist leads to the activation of NF-kappa-B (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.2.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.5", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "2.4.99.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20", "type": "external" } ], "go_molecular_function": "GO:0004908 interleukin-1 receptor activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0016787 hydrolase activity;GO:0004909 interleukin-1, type I, activating receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0032755 positive regulation of interleukin-6 production;GO:0050727 regulation of inflammatory response;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62929-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62638-1", "uniprot_id": [ { "id": "GSLG1_RAT", "url": "https://www.uniprot.org/uniprot/Q62638", "type": "external" } ], "mass": 133557.0, "length": 1171, "protein_name": "Golgi apparatus protein 1", "gene_name": "Glg1", "organism": "Rat", "refseq_name": "Golgi apparatus protein 1 precursor", "refseq_ac": [ { "id": "NP_058907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058907", "type": "external" } ], "gene_names_uniprotkb": "Glg1; Esl1; Mg160", "gene_names_refseq": "Glg1; MG-160; Selel", "protein_names_uniprotkb": "Golgi apparatus protein 1; E-selectin ligand 1; ESL-1; Golgi sialoglycoprotein MG-160", "protein_names_refseq": "E-selectin ligand 1; ESL-1; Golgi apparatus protein 1 precursor; golgi apparatus protein 1; golgi sialoglycoprotein MG-160; selectin, endothelial cell, ligand", "tax_id": 10116, "disease": "", "pathway": " (rno:29476); (R-RNO-202733)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "19148508;2909545;38843836;7768993", "class_list": "", "function": "Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils)., [UniProtKB, UniProtKB]; Under hypoxia, ESL-1 is shed from activated hepatic stellate cells, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix;GO:0005815 microtubule organizing center;GO:0005797 Golgi medial cisterna", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0060349 bone morphogenesis;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032330 regulation of chondrocyte differentiation;GO:0010955 negative regulation of protein processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62638-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62782-1", "uniprot_id": [ { "id": "PHX2A_RAT", "url": "https://www.uniprot.org/uniprot/Q62782", "type": "external" } ], "mass": 29525.0, "length": 281, "protein_name": "Paired mesoderm homeobox protein 2A", "gene_name": "Phox2a", "organism": "Rat", "refseq_name": "paired mesoderm homeobox protein 2A", "refseq_ac": [ { "id": "NP_446321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446321", "type": "external" } ], "gene_names_uniprotkb": "Phox2a; Arix; Pmx2a", "gene_names_refseq": "Arix; Phox2a", "protein_names_uniprotkb": "Paired mesoderm homeobox protein 2A; ARIX1 homeodomain protein; Aristaless homeobox protein homolog; Paired-like homeobox 2A", "protein_names_refseq": "ARIX1 homeodomain protein; aristaless homeobox protein homolog; paired mesoderm homeobox protein 2A", "tax_id": 10116, "disease": "congenital fibrosis of the extraocular muscles 2 (Disease Ontology:DOID:0081016); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:116648)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20215354;20437524;21763404;8613746", "class_list": "", "function": "Data show that exogenous Phox2a delivery to embryonic chick midbrain can drive a complete oculomotor complex molecular program, including the production of visceral and somatic motoneurons., [RefSeq, PubMed]; Mapped the distribution of Phox2a in the adult rat brain; data support the conclusion that Phox2a plays an important role in brainstem catecholamine neurotransmission and in the regulation of adaptive homeostatic functions in the adult nervous system, [RefSeq, PubMed]; May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype (By similarity)., [UniProtKB, UniProtKB]; The present study demonstrates an upregulatory effect of Phox2a and Phox2b on the expression of dopamine beta-hydroxylase and norepinephrine transporter in noradrenergic neurons of rat brains, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0048486 parasympathetic nervous system development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0021623 oculomotor nerve formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q62782-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62798-1", "uniprot_id": [ { "id": "DRGX_RAT", "url": "https://www.uniprot.org/uniprot/Q62798", "type": "external" } ], "mass": 28621.0, "length": 263, "protein_name": "Dorsal root ganglia homeobox protein", "gene_name": "Drgx", "organism": "Rat", "refseq_name": "dorsal root ganglia homeobox protein", "refseq_ac": [ { "id": "NP_665710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665710", "type": "external" } ], "gene_names_uniprotkb": "Drgx; Drg11; Prrxl1", "gene_names_refseq": "Drg11; Drgx; Prrxl1", "protein_names_uniprotkb": "Dorsal root ganglia homeobox protein; Dorsal root ganglion 11; Homeobox protein DRG11; Paired-related homeobox protein-like 1", "protein_names_refseq": "dorsal root ganglia homeobox protein; dorsal root ganglion 11; homeobox protein DRG11; paired-like homeodomain trancription factor Drg11; paired-related homeobox protein-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:252880)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "32000573;7496632", "class_list": "", "function": "Dorsal Root Ganglia Homeobox downregulation in primary sensory neurons contributes to neuropathic pain in rats., [RefSeq, PubMed]; Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009593 detection of chemical stimulus;GO:0021516 dorsal spinal cord development;GO:0050954 sensory perception of mechanical stimulus;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62798-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY37-1", "uniprot_id": [ { "id": "MAGBG_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY37", "type": "external" } ], "mass": 40525.0, "length": 360, "protein_name": "Melanoma-associated antigen B16", "gene_name": "Mageb16", "organism": "Rat", "refseq_name": "melanoma-associated antigen B16", "refseq_ac": [ { "id": "NP_001020184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020184", "type": "external" } ], "gene_names_uniprotkb": "Mageb16", "gene_names_refseq": "Mageb16; Snca", "protein_names_uniprotkb": "Melanoma-associated antigen B16; MAGE-B16 antigen", "protein_names_refseq": "MAGE-B16 antigen; melanoma antigen family B, 16; melanoma-associated antigen B16", "tax_id": 10116, "disease": "", "pathway": " (rno:317274)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY37-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6V0K7-1", "uniprot_id": [ { "id": "OIT3_RAT", "url": "https://www.uniprot.org/uniprot/Q6V0K7", "type": "external" } ], "mass": 60179.0, "length": 546, "protein_name": "Oncoprotein-induced transcript 3 protein", "gene_name": "Oit3", "organism": "Rat", "refseq_name": "oncoprotein-induced transcript 3 protein precursor", "refseq_ac": [ { "id": "NP_001001507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001507", "type": "external" } ], "gene_names_uniprotkb": "Oit3; Lzp", "gene_names_refseq": "Lzp; Oit3", "protein_names_uniprotkb": "Oncoprotein-induced transcript 3 protein; Liver-specific zona pellucida domain-containing protein", "protein_names_refseq": "liver-specific zona pellucida domain-containing protein; oncoprotein-induced transcript 3 protein precursor; oncoprotein-induced transcript 3 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:294559)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15346761;18830570", "class_list": "", "function": "May be involved in hepatocellular function and development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sequence analysis revealed that human, rat and mouse LZP proteins are highly conserved., [RefSeq, PubMed]; The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0009986 cell surface", "go_biological_process": "GO:0003014 renal system process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6V0K7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KRC5-1", "uniprot_id": [ { "id": "DUS3L_RAT", "url": "https://www.uniprot.org/uniprot/Q3KRC5", "type": "external" } ], "mass": 71540.0, "length": 640, "protein_name": "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like", "gene_name": "Dus3l", "organism": "Rat", "refseq_name": "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like", "refseq_ac": [ { "id": "NP_001030095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030095", "type": "external" } ], "gene_names_uniprotkb": "Dus3l", "gene_names_refseq": "Dus3l", "protein_names_uniprotkb": "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; 1.3.1.-; 1.3.1.89; mRNA-dihydrouridine synthase DUS3L; tRNA-dihydrouridine synthase 3-like", "protein_names_refseq": "mRNA-dihydrouridine synthase DUS3L; tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like", "tax_id": 10116, "disease": "", "pathway": " (rno:301122)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.-", "type": "external" }, { "id": "1.3.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.89", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0017150 tRNA dihydrouridine synthase activity;GO:0106414 mRNA dihydrouridine synthase activity;GO:0102265 tRNA-dihydrouridine47 synthase activity", "go_cellular_component": "", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0002943 tRNA dihydrouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3KRC5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXX2-1", "uniprot_id": [ { "id": "CP046_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXX2", "type": "external" } ], "mass": 44904.0, "length": 406, "protein_name": "Uncharacterized protein C16orf46 homolog", "gene_name": "C19h16orf46", "organism": "Rat", "refseq_name": "uncharacterized protein C16orf46 homolog", "refseq_ac": [ { "id": "NP_001094485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094485", "type": "external" } ], "gene_names_uniprotkb": "C19h16orf46; LOC687399", "gene_names_refseq": "C19h16orf46", "protein_names_uniprotkb": "Uncharacterized protein C16orf46 homolog", "protein_names_refseq": "uncharacterized protein C16orf46 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:687399)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXX2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8C3-1", "uniprot_id": [ { "id": "EMAL1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8C3", "type": "external" } ], "mass": 89802.0, "length": 814, "protein_name": "Echinoderm microtubule-associated protein-like 1", "gene_name": "Eml1", "organism": "Rat", "refseq_name": "echinoderm microtubule-associated protein-like 1 isoform 5", "refseq_ac": [ { "id": "NP_001020912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020912", "type": "external" } ], "gene_names_uniprotkb": "Eml1", "gene_names_refseq": "Eml1", "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like 1; EMAP-1", "protein_names_refseq": "EMAP-1; echinoderm microtubule associated protein like 1; echinoderm microtubule-associated protein-like 1 isoform 5", "tax_id": 10116, "disease": "subcortical band heterotopia (Disease Ontology:DOID:0111169); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); epilepsy (Disease Ontology:DOID:1826); congenital nervous system abnormality (Disease Ontology:DOID:2490); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (rno:362783)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;32179177;38897390", "class_list": "", "function": "A deletion in Eml1 leads to bilateral subcortical heterotopia in the tish rat., [RefSeq, PubMed]; Eml1 promotes axonal growth by enhancing alphaTAT1-mediated microtubule acetylation., [RefSeq, PubMed]; Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0097431 mitotic spindle pole", "go_biological_process": "GO:0007420 brain development;GO:0000226 microtubule cytoskeleton organization;GO:0002244 hematopoietic progenitor cell differentiation;GO:0007405 neuroblast proliferation;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q4V8C3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63398-1", "uniprot_id": [ { "id": "COE1_RAT", "url": "https://www.uniprot.org/uniprot/Q63398", "type": "external" } ], "mass": 63650.0, "length": 584, "protein_name": "Transcription factor COE1", "gene_name": "Ebf1; Ebf3", "organism": "Rat", "refseq_name": "transcription factor COE1", "refseq_ac": [ { "id": "NP_446272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446272", "type": "external" } ], "gene_names_uniprotkb": "Ebf1; Ebf3; Coe1; Ebf1; Ebf; Olf1", "gene_names_refseq": "Ebf1; Ebf; Olf1", "protein_names_uniprotkb": "Transcription factor COE1; Early B-cell factor; O/E-1; OE-1; Olf-1; Olfactory neuronal transcription factor", "protein_names_refseq": "OE-1; early B-cell factor (olfactory neuronal transcription factor 1); early B-cell factor 1; o/E-1; olf-1; olfactory neuronal transcription factor; transcription factor COE1", "tax_id": 10116, "disease": "hypotonia, ataxia, and delayed development syndrome (Disease Ontology:DOID:0081176); lipodystrophy (Disease Ontology:DOID:811)", "pathway": " (rno:116543); (rno:361668)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "8321284;9151733", "class_list": "", "function": "Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transcriptional activator. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63398-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q10753-1", "uniprot_id": [ { "id": "CEAB_RAT", "url": "https://www.uniprot.org/uniprot/Q10753", "type": "external" } ], "mass": 3290.0, "length": 30, "protein_name": "80 kDa carcinoembryonic antigen-binding protein", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "80 kDa carcinoembryonic antigen-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1445312;8638924", "class_list": "", "function": "May play a role in the development of hepatic metastases from colorectal cancers., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0036038 MKS complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q10753-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1HG60-1", "uniprot_id": [ { "id": "PIF1_RAT", "url": "https://www.uniprot.org/uniprot/Q1HG60", "type": "external" } ], "mass": 69758.0, "length": 637, "protein_name": "ATP-dependent DNA helicase PIF1", "gene_name": "Pif1", "organism": "Rat", "refseq_name": "ATP-dependent DNA helicase PIF1", "refseq_ac": [ { "id": "NP_001037718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037718", "type": "external" } ], "gene_names_uniprotkb": "Pif1", "gene_names_refseq": "Pif1", "protein_names_uniprotkb": "ATP-dependent DNA helicase PIF1; 5.6.2.3; DNA 5'-3' helicase PIF1; DNA repair and recombination helicase PIF1; PIF1/RRM3 DNA helicase-like protein", "protein_names_refseq": "ATP-dependent DNA helicase PIF1; DNA 5'-3' helicase PIF1; DNA repair and recombination helicase PIF1; PIF1/RRM3 DNA helicase-like protein; Pif1/Rrm3 DNA-helicase-like protein", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); progeria (Disease Ontology:DOID:3911)", "pathway": " (rno:367645); (R-RNO-171319)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042162 telomeric DNA binding;GO:0051880 G-quadruplex DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0000723 telomere maintenance;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0001117 protein-DNA-RNA complex disassembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1HG60-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1XID0-1", "uniprot_id": [ { "id": "LBX1_RAT", "url": "https://www.uniprot.org/uniprot/Q1XID0", "type": "external" } ], "mass": 30433.0, "length": 285, "protein_name": "Transcription factor LBX1", "gene_name": "Lbx1", "organism": "Rat", "refseq_name": "transcription factor LBX1", "refseq_ac": [ { "id": "NP_001040573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040573", "type": "external" } ], "gene_names_uniprotkb": "Lbx1; Lbx1h", "gene_names_refseq": "Lbx1; RGD1564197", "protein_names_uniprotkb": "Transcription factor LBX1; Ladybird homeobox protein homolog 1", "protein_names_refseq": "lady bird-like homeobox 1 homolog; ladybird homeobox protein homolog 1; transcription factor LBX1", "tax_id": 10116, "disease": "congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731)", "pathway": " (rno:499362)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045665 negative regulation of neuron differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1XID0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32PY2-1", "uniprot_id": [ { "id": "LIPH_RAT", "url": "https://www.uniprot.org/uniprot/Q32PY2", "type": "external" } ], "mass": 50826.0, "length": 451, "protein_name": "Lipase member H", "gene_name": "AABR07034648.1; Liph", "organism": "Rat", "refseq_name": "lipase member H precursor", "refseq_ac": [ { "id": "NP_001037744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037744", "type": "external" } ], "gene_names_uniprotkb": "AABR07034648.1; Liph; AABR07034648.1; Liph", "gene_names_refseq": "Liph", "protein_names_uniprotkb": "Lipase member H; 3.1.1.-", "protein_names_refseq": "lipase member H precursor; lipase, member H", "tax_id": 10116, "disease": "hypotrichosis 7 (Disease Ontology:DOID:0110704)", "pathway": " (rno:681694); (R-RNO-1483166)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid (By similarity). Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6S8", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008201 heparin binding;GO:0052689 carboxylic ester hydrolase activity;GO:0004620 phospholipase activity;GO:0046872 metal ion binding;GO:0016298 lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0006654 phosphatidic acid biosynthetic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32PY2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32Q05-1", "uniprot_id": [ { "id": "OTU1_RAT", "url": "https://www.uniprot.org/uniprot/Q32Q05", "type": "external" } ], "mass": 37402.0, "length": 343, "protein_name": "Ubiquitin thioesterase OTU1", "gene_name": "Yod1", "organism": "Rat", "refseq_name": "ubiquitin thioesterase OTU1", "refseq_ac": [ { "id": "NP_001008889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008889", "type": "external" } ], "gene_names_uniprotkb": "Yod1; Hshin7", "gene_names_refseq": "Yod1; hshin7", "protein_names_uniprotkb": "Ubiquitin thioesterase OTU1; 3.4.19.12", "protein_names_refseq": "HIV-induced protein-7-like protease; YOD1 OTU deubiquinating enzyme 1 homolog; YOD1 OTU deubiquitinating enzyme 1 homologue; ubiquitin thioesterase OTU1", "tax_id": 10116, "disease": "", "pathway": " (rno:363982); (R-RNO-5689896)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15060002;38042492", "class_list": "", "function": "Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation., [UniProtKB, UniProtKB]; TRIM54 alleviates inflammation and apoptosis by stabilizing YOD1 in rat tendon-derived stem cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IE74", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0070536 protein K63-linked deubiquitination;GO:0016236 macroautophagy;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q32Q05-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR51-1", "uniprot_id": [ { "id": "NSG2_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR51", "type": "external" } ], "mass": 18986.0, "length": 171, "protein_name": "Neuronal vesicle trafficking-associated protein 2", "gene_name": "Nsg2", "organism": "Rat", "refseq_name": "neuronal vesicle trafficking-associated protein 2", "refseq_ac": [ { "id": "NP_001029324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029324", "type": "external" } ], "gene_names_uniprotkb": "Nsg2", "gene_names_refseq": "Hmp19; Nsg2", "protein_names_uniprotkb": "Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2", "protein_names_refseq": "neuron specific gene family member 2; neuron-specific protein family member 2; neuronal vesicle trafficking-associated protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:497878)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28874679", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032051 clathrin light chain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:1990674 Golgi cis cisterna membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0016197 endosomal transport;GO:0048268 clathrin coat assembly;GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KR51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63313-1", "uniprot_id": [ { "id": "LBP_RAT", "url": "https://www.uniprot.org/uniprot/Q63313", "type": "external" } ], "mass": 53600.0, "length": 481, "protein_name": "Lipopolysaccharide-binding protein", "gene_name": "Lbp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lbp", "gene_names_refseq": "", "protein_names_uniprotkb": "Lipopolysaccharide-binding protein; LBP", "protein_names_refseq": "", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); obstructive jaundice (Disease Ontology:DOID:13603); liver cirrhosis (Disease Ontology:DOID:5082); periodontitis (Disease Ontology:DOID:824); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29469); (R-RNO-166016); (R-RNO-166020); (R-RNO-5686938)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8021509", "class_list": "", "function": "Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0001530 lipopolysaccharide binding;GO:0071723 lipopeptide binding;GO:0070891 lipoteichoic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0090559 regulation of membrane permeability;GO:0001889 liver development;GO:0032496 response to lipopolysaccharide;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63313-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1J9-1", "uniprot_id": [ { "id": "MOB1A_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1J9", "type": "external" } ], "mass": 25080.0, "length": 216, "protein_name": "MOB kinase activator 1A", "gene_name": "Mob1al1; Mob1a", "organism": "Rat", "refseq_name": "MOB kinase activator 1A", "refseq_ac": [ { "id": "NP_001029063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029063", "type": "external" } ], "gene_names_uniprotkb": "Mob1al1; Mob1a; Mob1al1; Mobk1b; Mobkl1b", "gene_names_refseq": "Mob1a; Mobk1b; Mobkl1b", "protein_names_uniprotkb": "MOB kinase activator 1A; Mob1 homolog 1B; Mps one binder kinase activator-like 1B", "protein_names_refseq": "MOB kinase activator 1A; Mob4B protein-like; mob1 homolog 1B; mps one binder kinase activator-like 1B", "tax_id": 10116, "disease": "", "pathway": " (rno:297387); (R-RNO-2028269)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0035329 hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T1J9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498D6-1", "uniprot_id": [ { "id": "FGFR4_RAT", "url": "https://www.uniprot.org/uniprot/Q498D6", "type": "external" } ], "mass": 88708.0, "length": 800, "protein_name": "Fibroblast growth factor receptor 4", "gene_name": "Fgfr4", "organism": "Rat", "refseq_name": "fibroblast growth factor receptor 4 precursor", "refseq_ac": [ { "id": "NP_001103374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103374", "type": "external" } ], "gene_names_uniprotkb": "Fgfr4", "gene_names_refseq": "Fgfr4", "protein_names_uniprotkb": "Fibroblast growth factor receptor 4; 2.7.10.1; FGFR-4", "protein_names_refseq": "FGFR-4; fibroblast growth factor receptor 4 precursor", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); bone disease (Disease Ontology:DOID:0080001); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); colon cancer (Disease Ontology:DOID:219); high grade glioma (Disease Ontology:DOID:3070); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); liver cirrhosis (Disease Ontology:DOID:5082); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:25114); (R-RNO-109704); (R-RNO-1257604); (R-RNO-1307965); (R-RNO-190322); (R-RNO-5654228); (R-RNO-5654712); (R-RNO-5654719); (R-RNO-5654720); (R-RNO-5654733); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 12, "publication_count": 2, "publication_id_list": "17623664;28339837", "class_list": "", "function": "High FGFr4 expression is associated with cardiac hypertrophy., [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0005524 ATP binding;GO:0008201 heparin binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0070857 regulation of bile acid biosynthetic process;GO:0001759 organ induction;GO:0010966 regulation of phosphate transport;GO:0051174 regulation of phosphorus metabolic process;GO:0061144 alveolar secondary septum development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q498D6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499U2-1", "uniprot_id": [ { "id": "ELMO3_RAT", "url": "https://www.uniprot.org/uniprot/Q499U2", "type": "external" } ], "mass": 81659.0, "length": 720, "protein_name": "Engulfment and cell motility protein 3", "gene_name": "Elmo3", "organism": "Rat", "refseq_name": "engulfment and cell motility protein 3", "refseq_ac": [ { "id": "NP_001025199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025199", "type": "external" } ], "gene_names_uniprotkb": "Elmo3", "gene_names_refseq": "Elmo3", "protein_names_uniprotkb": "Engulfment and cell motility protein 3", "protein_names_refseq": "engulfment and cell motility 3, ced-12 homolog; engulfment and cell motility protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:291962)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007015 actin filament organization;GO:0006909 phagocytosis;GO:0006915 apoptotic process;GO:0048870 cell motility;GO:2001212 regulation of vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499U2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G012-1", "uniprot_id": [ { "id": "FMC1_RAT", "url": "https://www.uniprot.org/uniprot/Q4G012", "type": "external" } ], "mass": 12745.0, "length": 113, "protein_name": "Protein FMC1 homolog", "gene_name": "Fmc1", "organism": "Rat", "refseq_name": "protein FMC1 homolog", "refseq_ac": [ { "id": "NP_001032884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032884", "type": "external" } ], "gene_names_uniprotkb": "Fmc1", "gene_names_refseq": "Fmc1", "protein_names_uniprotkb": "Protein FMC1 homolog; Formation of mitochondrial complex V assembly factor 1 homolog", "protein_names_refseq": "UPF0562 protein C7orf55 homolog; formation of mitochondrial complex V assembly factor 1 homolog; formation of mitochondrial complexes 1 homolog; protein FMC1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500087)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0050995 negative regulation of lipid catabolic process;GO:0009636 response to toxic substance;GO:0007005 mitochondrion organization;GO:0008637 apoptotic mitochondrial changes;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4G012-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G072-1", "uniprot_id": [ { "id": "LPAR6_RAT", "url": "https://www.uniprot.org/uniprot/Q4G072", "type": "external" } ], "mass": 39330.0, "length": 344, "protein_name": "Lysophosphatidic acid receptor 6", "gene_name": "Lpar6", "organism": "Rat", "refseq_name": "lysophosphatidic acid receptor 6", "refseq_ac": [ { "id": "NP_001039308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039308", "type": "external" } ], "gene_names_uniprotkb": "Lpar6; P2ry5; P2y5", "gene_names_refseq": "Lpar6; P2ry5", "protein_names_uniprotkb": "Lysophosphatidic acid receptor 6; LPA receptor 6; LPA-6; Oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; Purinergic receptor 5", "protein_names_refseq": "LPA receptor 6; LPA-6; P2Y purinoceptor 5; P2Y5; lysophosphatidic acid receptor 6; oleoyl-L-alpha-lysophosphatidic acid receptor; purinergic receptor 5; purinergic receptor P2Y, G-protein coupled, 5", "tax_id": 10116, "disease": "hypotrichosis 8 (Disease Ontology:DOID:0110705)", "pathway": " (rno:691774); (R-RNO-416476); (R-RNO-417957)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19679818;29778535", "class_list": "", "function": "Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture (By similarity)., [UniProtKB]; P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion., [RefSeq, PubMed]; The up-regulation of serum ATX in hepatic encephalopathy may activate the LPA-LPA6-G12/13-Rho pathway in brain capillary endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070915 lysophosphatidic acid receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4G072-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G078-1", "uniprot_id": [ { "id": "MTEF4_RAT", "url": "https://www.uniprot.org/uniprot/Q4G078", "type": "external" } ], "mass": 40381.0, "length": 347, "protein_name": "Transcription termination factor 4, mitochondrial", "gene_name": "Mterf4", "organism": "Rat", "refseq_name": "transcription termination factor 4, mitochondrial", "refseq_ac": [ { "id": "NP_001032286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032286", "type": "external" } ], "gene_names_uniprotkb": "Mterf4; Mterfd2", "gene_names_refseq": "Mterf4; Mterfd2", "protein_names_uniprotkb": "Transcription termination factor 4, mitochondrial; Mitochondrial transcription termination factor 4; mTERF domain-containing protein 2", "protein_names_refseq": "MTERF domain containing 2; mTERF domain-containing protein 2; transcription termination factor 4, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:363289)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0140517 protein-RNA adaptor activity;GO:0140691 RNA folding chaperone;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0007507 heart development;GO:0006364 rRNA processing;GO:0043010 camera-type eye development;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0061668 mitochondrial ribosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4G078-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLL9-1", "uniprot_id": [ { "id": "KI18B_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLL9", "type": "external" } ], "mass": 91195.0, "length": 826, "protein_name": "Kinesin-like protein KIF18B", "gene_name": "Kif18b", "organism": "Rat", "refseq_name": "kinesin-like protein KIF18B isoform 2", "refseq_ac": [ { "id": "NP_001034108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034108", "type": "external" } ], "gene_names_uniprotkb": "Kif18b", "gene_names_refseq": "Kif18b; RGD1310360", "protein_names_uniprotkb": "Kinesin-like protein KIF18B", "protein_names_refseq": "kinesin-like protein KIF18B isoform 2; kinesin-like protein KIF18B-like; kinesin-like protein KIF18B", "tax_id": 10116, "disease": "", "pathway": " (rno:303575); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0019894 kinesin binding;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0000235 astral microtubule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007019 microtubule depolymerization;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLL9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM31-1", "uniprot_id": [ { "id": "LIMD2_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM31", "type": "external" } ], "mass": 14236.0, "length": 128, "protein_name": "LIM domain-containing protein 2", "gene_name": "Limd2", "organism": "Rat", "refseq_name": "LIM domain-containing protein 2", "refseq_ac": [ { "id": "NP_001020886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020886", "type": "external" } ], "gene_names_uniprotkb": "Limd2", "gene_names_refseq": "Limd2; RGD1309967", "protein_names_uniprotkb": "LIM domain-containing protein 2", "protein_names_refseq": "LIM domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:360646)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an activator of the protein-kinase ILK, thereby regulating cell motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0051017 actin filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KM31-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM34-1", "uniprot_id": [ { "id": "CDK20_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM34", "type": "external" } ], "mass": 38449.0, "length": 346, "protein_name": "Cyclin-dependent kinase 20", "gene_name": "Cdk20", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 20", "refseq_ac": [ { "id": "NP_001020923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020923", "type": "external" } ], "gene_names_uniprotkb": "Cdk20; Ccrk", "gene_names_refseq": "Ccrk; Cdk20", "protein_names_uniprotkb": "Cyclin-dependent kinase 20; 2.7.11.22; Cell cycle-related kinase; Cell division protein kinase 20", "protein_names_refseq": "cell cycle-related kinase; cell division protein kinase 20; cyclin-dependent kinase 20", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (rno:364666)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18508765", "class_list": "", "function": "Heart expresses a splice variant of CCRK, which promotes cardiac cell growth and survival; differs from the generic isoform in protein-protein interactions, substrate specificity and regulation of cell cycle; and is down-regulated in heart failure, [RefSeq, PubMed]; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005929 cilium", "go_biological_process": "GO:0021508 floor plate formation;GO:0051301 cell division;GO:0001843 neural tube closure;GO:0031076 embryonic camera-type eye development;GO:0060021 roof of mouth development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM34-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM37-1", "uniprot_id": [ { "id": "CEP41_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM37", "type": "external" } ], "mass": 36992.0, "length": 339, "protein_name": "Centrosomal protein of 41 kDa", "gene_name": "Cep41", "organism": "Rat", "refseq_name": "centrosomal protein of 41 kDa isoform 1", "refseq_ac": [ { "id": "NP_001020941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020941", "type": "external" } ], "gene_names_uniprotkb": "Cep41; Tsga14", "gene_names_refseq": "Cep41; Tsga14", "protein_names_uniprotkb": "Centrosomal protein of 41 kDa; Cep41; Testis-specific gene A14 protein", "protein_names_refseq": "centrosomal protein 41kDa; centrosomal protein of 41 kDa isoform 1; centrosomal protein of 41 kDa; testis specific gene A14; testis specific, 14; testis-specific gene A14 protein", "tax_id": 10116, "disease": "Joubert syndrome 15 (Disease Ontology:DOID:0110984)", "pathway": " (rno:500069); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-8854518)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LXL2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0018095 protein polyglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM37-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM86-1", "uniprot_id": [ { "id": "GGACT_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM86", "type": "external" } ], "mass": 16925.0, "length": 149, "protein_name": "Gamma-glutamylaminecyclotransferase", "gene_name": "Ggact", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ggact; A2ld1", "gene_names_refseq": "", "protein_names_uniprotkb": "Gamma-glutamylaminecyclotransferase; 4.3.2.8; AIG2-like domain-containing protein 1; GGACT; Gamma-glutamylamine cyclotransferase", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine., [UniProtKB, UniProtKB]; Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.8", "type": "external" } ], "go_molecular_function": "GO:0061929 gamma-glutamylaminecyclotransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0042219 modified amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KM86-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KMC4-1", "uniprot_id": [ { "id": "GFPT2_RAT", "url": "https://www.uniprot.org/uniprot/Q4KMC4", "type": "external" } ], "mass": 77010.0, "length": 682, "protein_name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2", "gene_name": "Gfpt2", "organism": "Rat", "refseq_name": "glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2", "refseq_ac": [ { "id": "NP_001002819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002819", "type": "external" } ], "gene_names_uniprotkb": "Gfpt2", "gene_names_refseq": "Gfpt2", "protein_names_uniprotkb": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; 2.6.1.16; D-fructose-6-phosphate amidotransferase 2; GFAT 2; GFAT2; Glutamine:fructose-6-phosphate amidotransferase 2; Hexosephosphate aminotransferase 2", "protein_names_refseq": "D-fructose-6-phosphate amidotransferase 2; GFAT 2; GFAT2; glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; glutamine:fructose-6-phosphate amidotransferase 2; hexosephosphate aminotransferase 2", "tax_id": 10116, "disease": "Machado-Joseph disease (Disease Ontology:DOID:1440); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:360518); (R-RNO-446210)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;34735873", "class_list": "", "function": "Cardiomyocyte protein O-GlcNAcylation is regulated by GFAT1 not GFAT2., [RefSeq, PubMed]; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.16", "type": "external" } ], "go_molecular_function": "GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity;GO:0097367 carbohydrate derivative binding", "go_cellular_component": "", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0006487 protein N-linked glycosylation;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0006047 UDP-N-acetylglucosamine metabolic process;GO:0006002 fructose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KMC4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQT3-1", "uniprot_id": [ { "id": "CELF1_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQT3", "type": "external" } ], "mass": 52205.0, "length": 487, "protein_name": "CUGBP Elav-like family member 1", "gene_name": "Celf1", "organism": "Rat", "refseq_name": "CUGBP Elav-like family member 1 isoform e", "refseq_ac": [ { "id": "NP_001020592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020592", "type": "external" } ], "gene_names_uniprotkb": "Celf1; Cugbp1", "gene_names_refseq": "Celf1; Cugbp1", "protein_names_uniprotkb": "CUGBP Elav-like family member 1; Bruno-like protein 2; CELF-1; CUG triplet repeat RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; CUG-BP1; RNA-binding protein BRUNOL-2", "protein_names_refseq": "CELF-1; CUG triplet repeat RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; CUG-BP1; CUGBP Elav-like family member 1 isoform e; RNA-binding protein BRUNOL-2; bruno-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:362160)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10536163;16754681;26283512;30514107", "class_list": "", "function": "A sustained suppression of IEC proliferation evoked by CELF1/p53 axis., [RefSeq, PubMed]; CUG triplet repeat-binding protein-1 has a role in adipogenesis with aging, [RefSeq, PubMed]; Demonstrated that CUGBP1 expression was positively correlated with PCNA expression, and the p27 expression was negatively correlated with CUGBP1 expression following LPS stimulation, [RefSeq, PubMed]; RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver. Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0042835 BRE binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0021987 cerebral cortex development;GO:0050680 negative regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4QQT3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7A4-1", "uniprot_id": [ { "id": "FSCB_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7A4", "type": "external" } ], "mass": 88050.0, "length": 812, "protein_name": "Fibrous sheath CABYR-binding protein", "gene_name": "Fscb", "organism": "Rat", "refseq_name": "fibrous sheath CABYR-binding protein", "refseq_ac": [ { "id": "NP_001258036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258036", "type": "external" } ], "gene_names_uniprotkb": "Fscb", "gene_names_refseq": "Fscb", "protein_names_uniprotkb": "Fibrous sheath CABYR-binding protein", "protein_names_refseq": "fibrous sheath CABYR-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:500659)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in the later stages of fibrous sheath biogenesis. Binds calcium (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0035686 sperm fibrous sheath;GO:0097228 sperm principal piece", "go_biological_process": "GO:0033234 negative regulation of protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7A4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7E2-1", "uniprot_id": [ { "id": "PLAC1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7E2", "type": "external" } ], "mass": 19546.0, "length": 173, "protein_name": "Placenta-specific protein 1", "gene_name": "Plac1", "organism": "Rat", "refseq_name": "placenta-specific protein 1 precursor", "refseq_ac": [ { "id": "NP_001020065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020065", "type": "external" } ], "gene_names_uniprotkb": "Plac1", "gene_names_refseq": "Plac1", "protein_names_uniprotkb": "Placenta-specific protein 1", "protein_names_refseq": "placenta-specific 1; placenta-specific protein 1 precursor; placenta-specific protein 1-like; placenta-specific protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:317316)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in placental development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0001890 placenta development;GO:0090214 spongiotrophoblast layer developmental growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7E2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7F3-1", "uniprot_id": [ { "id": "OSGL1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7F3", "type": "external" } ], "mass": 44851.0, "length": 414, "protein_name": "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial", "gene_name": "Osgepl1", "organism": "Rat", "refseq_name": "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001380997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380997", "type": "external" } ], "gene_names_uniprotkb": "Osgepl1", "gene_names_refseq": "Osgepl1", "protein_names_uniprotkb": "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotein endopeptidase-like protein 1; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1; tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1", "protein_names_refseq": "N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotein endopeptidase-like protein 1; probable O-sialoglycoprotein endopeptidase 2; probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; probable tRNA threonylcarbamoyladenosine biosynthesis protein Osgepl1; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgepl1; tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:314548)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19694617", "class_list": "", "function": "Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.234", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.234", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V7F3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V890-1", "uniprot_id": [ { "id": "FEM1A_RAT", "url": "https://www.uniprot.org/uniprot/Q4V890", "type": "external" } ], "mass": 72118.0, "length": 654, "protein_name": "Protein fem-1 homolog A", "gene_name": "Fem1a", "organism": "Rat", "refseq_name": "protein fem-1 homolog A", "refseq_ac": [ { "id": "NP_001020877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020877", "type": "external" } ], "gene_names_uniprotkb": "Fem1a", "gene_names_refseq": "Fem1a", "protein_names_uniprotkb": "Protein fem-1 homolog A; FEM1-alpha; FEM1a", "protein_names_refseq": "FEM1-alpha; feminization 1 homolog a; feminization of XX and XO animals 1A; protein fem-1 homolog A", "tax_id": 10116, "disease": "", "pathway": " (rno:316131); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity). Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031867 EP4 subtype prostaglandin E2 receptor binding;GO:0060090 molecular adaptor activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050729 positive regulation of inflammatory response;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V890-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8A2-1", "uniprot_id": [ { "id": "CDC27_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8A2", "type": "external" } ], "mass": 91663.0, "length": 824, "protein_name": "Cell division cycle protein 27 homolog", "gene_name": "Cdc27", "organism": "Rat", "refseq_name": "cell division cycle protein 27 homolog isoform 2", "refseq_ac": [ { "id": "NP_001019964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019964", "type": "external" } ], "gene_names_uniprotkb": "Cdc27", "gene_names_refseq": "Cdc27", "protein_names_uniprotkb": "Cell division cycle protein 27 homolog", "protein_names_refseq": "cell division cycle protein 27 homolog isoform 2; cell division cycle protein 27 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:360643); (R-RNO-141430); (R-RNO-174048); (R-RNO-174084); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-176407); (R-RNO-176408); (R-RNO-176412); (R-RNO-179409); (R-RNO-2467813); (R-RNO-2559582); (R-RNO-68867); (R-RNO-69017); (R-RNO-983168)", "pathway_count": 16, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019903 protein phosphatase binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0031175 neuron projection development;GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8A2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8D1-1", "uniprot_id": [ { "id": "CP2U1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8D1", "type": "external" } ], "mass": 60399.0, "length": 530, "protein_name": "Cytochrome P450 2U1", "gene_name": "Cyp2u1", "organism": "Rat", "refseq_name": "cytochrome P450 2U1", "refseq_ac": [ { "id": "NP_001380742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380742", "type": "external" } ], "gene_names_uniprotkb": "Cyp2u1", "gene_names_refseq": "Cyp2u1", "protein_names_uniprotkb": "Cytochrome P450 2U1; 1.14.14.80; Long-chain fatty acid omega-monooxygenase", "protein_names_refseq": "cytochrome P450 2U1; long-chain fatty acid omega-monooxygenase", "tax_id": 10116, "disease": "hereditary spastic paraplegia 56 (Disease Ontology:DOID:0110808)", "pathway": " (rno:310848); (R-RNO-211958); (R-RNO-2142816)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "14975754", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" }, { "id": "1.14.14.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.94", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395 steroid hydroxylase activity;GO:0052869 arachidonate omega-hydroxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097267 omega-hydroxylase P450 pathway;GO:0006805 xenobiotic metabolic process;GO:0008202 steroid metabolic process;GO:0006082 organic acid metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V8D1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8E9-1", "uniprot_id": [ { "id": "NRIF1_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8E9", "type": "external" } ], "mass": 93628.0, "length": 822, "protein_name": "Neurotrophin receptor-interacting factor 1", "gene_name": "Nrif1; Zfp110", "organism": "Rat", "refseq_name": "neurotrophin receptor-interacting factor 1", "refseq_ac": [ { "id": "NP_001019946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019946", "type": "external" } ], "gene_names_uniprotkb": "Nrif1; Zfp110; Zfp110", "gene_names_refseq": "Nrif1; Zfp110", "protein_names_uniprotkb": "Neurotrophin receptor-interacting factor 1; Zinc finger protein 110", "protein_names_refseq": "neurotrophin receptor-interacting factor 1; zinc finger protein 274", "tax_id": 10116, "disease": "", "pathway": " (rno:308362); (R-RNO-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription regulator which may participate in NGFR/p75(NTR)-mediated apoptosis. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051402 neuron apoptotic process;GO:0046328 regulation of JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8E9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8G2-1", "uniprot_id": [ { "id": "EID3_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8G2", "type": "external" } ], "mass": 44785.0, "length": 387, "protein_name": "EP300-interacting inhibitor of differentiation 3", "gene_name": "Eid3", "organism": "Rat", "refseq_name": "EP300-interacting inhibitor of differentiation 3", "refseq_ac": [ { "id": "NP_001037769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037769", "type": "external" } ], "gene_names_uniprotkb": "Eid3", "gene_names_refseq": "Eid3; NS4EB", "protein_names_uniprotkb": "EP300-interacting inhibitor of differentiation 3; E1A-like inhibitor of differentiation 3; EID-1-like inhibitor of differentiation 3; EID-3; NS4EB; Non-SMC element 4 homolog B; Non-structural maintenance of chromosomes element 4 homolog B", "protein_names_refseq": "E1A-like inhibitor of differentiation 3; EID-1-like inhibitor of differentiation 3; EID-3; EP300-interacting inhibitor of differentiation 3; non-SMC element 4 homolog B; non-structural maintenance of chromosomes element 4 homolog B", "tax_id": 10116, "disease": "", "pathway": " (rno:691688); (R-RNO-3108214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors (By similarity)., [UniProtKB]; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8G2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q505J6-1", "uniprot_id": [ { "id": "GHC2_RAT", "url": "https://www.uniprot.org/uniprot/Q505J6", "type": "external" } ], "mass": 34170.0, "length": 320, "protein_name": "Mitochondrial glutamate carrier 2", "gene_name": "Slc25a18", "organism": "Rat", "refseq_name": "mitochondrial glutamate carrier 2", "refseq_ac": [ { "id": "NP_001037745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037745", "type": "external" } ], "gene_names_uniprotkb": "Slc25a18", "gene_names_refseq": "Slc25a18", "protein_names_uniprotkb": "Mitochondrial glutamate carrier 2; GC-2; Glutamate/H(+) symporter 2; Solute carrier family 25 member 18", "protein_names_refseq": "GC-2; glutamate carrier 2, mitochondrial; glutamate/H(+) symporter 2; mitochondrial glutamate carrier 2; solute carrier family 25 (glutamate carrier), member 18; solute carrier family 25 (mitochondrial carrier), member 18", "tax_id": 10116, "disease": "intrahepatic cholestasis (Disease Ontology:DOID:1852); common bile duct disease (Disease Ontology:DOID:4137); citrullinemia (Disease Ontology:DOID:9273)", "pathway": " (rno:681896); (R-RNO-442660); (R-RNO-9856872)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19584051", "class_list": "", "function": "Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005280 amino acid:proton symporter activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015810 aspartate transmembrane transport;GO:0015813 L-glutamate transmembrane transport;GO:0043490 malate-aspartate shuttle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q505J6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q561R0-1", "uniprot_id": [ { "id": "MZB1_RAT", "url": "https://www.uniprot.org/uniprot/Q561R0", "type": "external" } ], "mass": 20712.0, "length": 188, "protein_name": "Marginal zone B- and B1-cell-specific protein", "gene_name": "Mzb1", "organism": "Rat", "refseq_name": "marginal zone B- and B1-cell-specific protein precursor", "refseq_ac": [ { "id": "NP_001019411", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019411", "type": "external" } ], "gene_names_uniprotkb": "Mzb1; Pacap", "gene_names_refseq": "Mzb1; Pacap; RGD1310251; pERp1", "protein_names_uniprotkb": "Marginal zone B- and B1-cell-specific protein; Plasma cell-induced resident ER protein; Plasma cell-induced resident endoplasmic reticulum protein; Proapoptotic caspase adapter protein; pERp1", "protein_names_refseq": "marginal zone B- and B1-cell-specific protein precursor; plasma cell-induced resident ER protein; plasma cell-induced resident endoplasmic reticulum protein; proapoptotic caspase adapter protein", "tax_id": 10116, "disease": "", "pathway": " (rno:291675)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20379803;20387008;20699230;20703829;20728507", "class_list": "", "function": "Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance (By similarity)., [UniProtKB]; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation., [UniProtKB]; Data show that the presence of PACAP-38 in the small bowel tissue has a key role in the protection against intestinal cold preservation injury., [RefSeq, PubMed]; Data suggest that exogenous PACAP is able to counteract NMDA-induced toxicity, and that endogenous PACAP exerts a neuroprotective effect in the retina., [RefSeq, PubMed]; It is evident that PACAP-induced prodynorphin mRNA expression is mediated by the activation of the protein kinase A (PKA) pathway., [RefSeq, PubMed]; Results propose an important protective effect of endogenous PACAP-38 against intestinal warm ischemia, which provides basis for further investigation to elucidate the mechanism of this protective effect., [RefSeq, PubMed]; VIP and CRF, originating from interneurons, and PACAP, expressed mainly by pyramidal cells, finely tune the excitability and gene expression in the neocortical network, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0030888 regulation of B cell proliferation;GO:0033622 integrin activation;GO:0046626 regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q561R0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q566E5-1", "uniprot_id": [ { "id": "PLGT3_RAT", "url": "https://www.uniprot.org/uniprot/Q566E5", "type": "external" } ], "mass": 58701.0, "length": 508, "protein_name": "Protein O-glucosyltransferase 3", "gene_name": "Poglut3", "organism": "Rat", "refseq_name": "protein O-glucosyltransferase 3 precursor", "refseq_ac": [ { "id": "NP_001020294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020294", "type": "external" } ], "gene_names_uniprotkb": "Poglut3; Kdelc2", "gene_names_refseq": "Kdelc2; Poglut3", "protein_names_uniprotkb": "Protein O-glucosyltransferase 3; 2.4.1.-; 2.4.2.-; KDEL motif-containing protein 2; Protein O-xylosyltransferase POGLUT3", "protein_names_refseq": "KDEL (Lys-Asp-Glu-Leu) containing 2; KDEL motif containing 2; KDEL motif-containing protein 2; protein O-glucosyltransferase 3 precursor; protein O-xylosyltransferase POGLUT3", "tax_id": 10116, "disease": "", "pathway": " (rno:315664)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "glycogene;glycosyltransferase", "function": "Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q497C8", "ec_number_list": [ { "id": "2.4.1.376", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.376", "type": "external" }, { "id": "2.4.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.63", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0046527 glucosyltransferase activity;GO:0035252 UDP-xylosyltransferase activity;GO:0035251 UDP-glucosyltransferase activity;GO:0140561 EGF-domain serine glucosyltransferase activity;GO:0140562 EGF-domain serine xylosyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0012505 endomembrane system", "go_biological_process": "GO:0180059 protein O-linked glycosylation via glucose", "synthesized_glycan_count": 6710, "hit_score": 0.2, "record_id": "Q566E5-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q568Z9-1", "uniprot_id": [ { "id": "PHYIP_RAT", "url": "https://www.uniprot.org/uniprot/Q568Z9", "type": "external" } ], "mass": 37555.0, "length": 330, "protein_name": "Phytanoyl-CoA hydroxylase-interacting protein", "gene_name": "Phyhip", "organism": "Rat", "refseq_name": "phytanoyl-CoA hydroxylase-interacting protein", "refseq_ac": [ { "id": "NP_001017376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017376", "type": "external" } ], "gene_names_uniprotkb": "Phyhip", "gene_names_refseq": "Phyhip", "protein_names_uniprotkb": "Phytanoyl-CoA hydroxylase-interacting protein; PAHX-AP1; PAHXAP1; Phytanoyl-CoA hydroxylase-associated protein 1", "protein_names_refseq": "PAHX-AP1; PAHXAP1; phytanoyl-CoA hydroxylase-associated protein 1; phytanoyl-CoA hydroxylase-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:290356)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Its interaction with PHYH suggests a role in the development of the central system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q568Z9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJQ6-1", "uniprot_id": [ { "id": "CSTF1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJQ6", "type": "external" } ], "mass": 48382.0, "length": 431, "protein_name": "Cleavage stimulation factor subunit 1", "gene_name": "Cstf1", "organism": "Rat", "refseq_name": "cleavage stimulation factor subunit 1", "refseq_ac": [ { "id": "NP_001013179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013179", "type": "external" } ], "gene_names_uniprotkb": "Cstf1", "gene_names_refseq": "Cstf1", "protein_names_uniprotkb": "Cleavage stimulation factor subunit 1; CSTF 50 kDa subunit; Cleavage stimulation factor 50 kDa subunit; CstF-50", "protein_names_refseq": "CF-1 50 kDa subunit; CSTF 50 kDa subunit; cleavage stimulation factor 50 kDa subunit; cleavage stimulation factor subunit 1; cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa; cstF-50", "tax_id": 10116, "disease": "", "pathway": " (rno:311670); (R-RNO-73856); (R-RNO-77595); (R-RNO-9770562)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (By similarity). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005848 mRNA cleavage stimulating factor complex", "go_biological_process": "GO:0031124 mRNA 3'-end processing;GO:0031440 regulation of mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJQ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJS2-1", "uniprot_id": [ { "id": "LHPL6_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJS2", "type": "external" } ], "mass": 21666.0, "length": 200, "protein_name": "LHFPL tetraspan subfamily member 6 protein", "gene_name": "Lhfpl6", "organism": "Rat", "refseq_name": "LHFPL tetraspan subfamily member 6 protein precursor", "refseq_ac": [ { "id": "NP_001102653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102653", "type": "external" } ], "gene_names_uniprotkb": "Lhfpl6; Lhfp", "gene_names_refseq": "Lhfpl6; Lhfp; RGD1560177", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 6 protein; Lipoma HMGIC fusion partner", "protein_names_refseq": "LHFPL tetraspan subfamily member 6 protein precursor; LHFPL tetraspan subfamily member 6 protein; lipoma HMGIC fusion partner", "tax_id": 10116, "disease": "", "pathway": " (rno:499615)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJS2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK54-1", "uniprot_id": [ { "id": "LAG3_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK54", "type": "external" } ], "mass": 57988.0, "length": 525, "protein_name": "Lymphocyte activation gene 3 protein", "gene_name": "Lag3", "organism": "Rat", "refseq_name": "lymphocyte activation gene 3 protein precursor", "refseq_ac": [ { "id": "NP_997678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997678", "type": "external" } ], "gene_names_uniprotkb": "Lag3", "gene_names_refseq": "CD223; Lag3", "protein_names_uniprotkb": "Lymphocyte activation gene 3 protein; LAG-3", "protein_names_refseq": "LAG-3; lymphocyte activation gene 3 protein precursor; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3", "tax_id": 10116, "disease": "", "pathway": " (rno:297596); (R-RNO-2132295)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17785860;18091527", "class_list": "", "function": "LAG-3 binds to a minority of histocompatibility class II-positive cells in peripheral blood mononuclear leukocytes, including all myeloid dendritic cells, and a small fraction of monocytes., [RefSeq, PubMed]; Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with TCR-CD3 in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells. Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear., [UniProtKB, UniProtKB]; May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response., [UniProtKB, UniProtKB]; Targeting LAG-3-positive cells with cytotoxic antibodies is immunosuppressive in transplantation by depleting effectors T cells, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042289 MHC class II protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002270 plasmacytoid dendritic cell activation;GO:0032703 negative regulation of interleukin-2 production;GO:0007166 cell surface receptor signaling pathway;GO:0050776 regulation of immune response;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5BK54-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5D1Z3-1", "uniprot_id": [ { "id": "NOL12_RAT", "url": "https://www.uniprot.org/uniprot/Q5D1Z3", "type": "external" } ], "mass": 25186.0, "length": 216, "protein_name": "Nucleolar protein 12", "gene_name": "Nol12", "organism": "Rat", "refseq_name": "nucleolar protein 12", "refseq_ac": [ { "id": "NP_001012765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012765", "type": "external" } ], "gene_names_uniprotkb": "Nol12; Nop25", "gene_names_refseq": "Nol12; Nop25; RGD1305327", "protein_names_uniprotkb": "Nucleolar protein 12; 25 kDa nucleolar protein", "protein_names_refseq": "25 kDa nucleolar protein; nucleolar protein 12; nucleolar protein, 25 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:362955)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16430885;16515785;29393594", "class_list": "", "function": "Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly., [UniProtKB, UniProtKB]; These data suggest that the nucleolar targeting sequence might play an important role in the binding of Nop25 to RNA molecules and that the RNA binding of Nop25 might be essential for the nucleolar localization of Nop25., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0019843 rRNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5D1Z3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EAJ6-1", "uniprot_id": [ { "id": "IKIP_RAT", "url": "https://www.uniprot.org/uniprot/Q5EAJ6", "type": "external" } ], "mass": 42361.0, "length": 373, "protein_name": "Inhibitor of nuclear factor kappa-B kinase-interacting protein", "gene_name": "Ikbip", "organism": "Rat", "refseq_name": "inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 1", "refseq_ac": [ { "id": "NP_001009430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009430", "type": "external" } ], "gene_names_uniprotkb": "Ikbip; Ikip", "gene_names_refseq": "IKIP; Ikbip; RGD1305457", "protein_names_uniprotkb": "Inhibitor of nuclear factor kappa-B kinase-interacting protein; I kappa-B kinase-interacting protein; IKBKB-interacting protein; IKK-interacting protein", "protein_names_refseq": "IKK-interacting protein; i kappa-B kinase-interacting protein; inhibitor of nuclear factor kappa-B kinase-interacting protein isoform 1; inhibitor of nuclear factor kappa-B kinase-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:314730)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15389287", "class_list": "", "function": "Target of p53/TP53 with pro-apoptotic function., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5M859", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0032496 response to lipopolysaccharide;GO:0034612 response to tumor necrosis factor;GO:0070555 response to interleukin-1", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EAJ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVI3-1", "uniprot_id": [ { "id": "LRC57_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVI3", "type": "external" } ], "mass": 26724.0, "length": 239, "protein_name": "Leucine-rich repeat-containing protein 57", "gene_name": "Lrrc57", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 57", "refseq_ac": [ { "id": "NP_001012354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012354", "type": "external" } ], "gene_names_uniprotkb": "Lrrc57", "gene_names_refseq": "Lrrc57; RGD1307128", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 57", "protein_names_refseq": "leucine-rich repeat-containing protein 57-like; leucine-rich repeat-containing protein 57", "tax_id": 10116, "disease": "", "pathway": " (rno:311346)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVI3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVQ5-1", "uniprot_id": [ { "id": "LAX1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVQ5", "type": "external" } ], "mass": 43936.0, "length": 406, "protein_name": "Lymphocyte transmembrane adapter 1", "gene_name": "Lax1", "organism": "Rat", "refseq_name": "lymphocyte transmembrane adapter 1", "refseq_ac": [ { "id": "NP_001017491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017491", "type": "external" } ], "gene_names_uniprotkb": "Lax1; Lax", "gene_names_refseq": "Lax1", "protein_names_uniprotkb": "Lymphocyte transmembrane adapter 1; Membrane-associated adapter protein LAX", "protein_names_refseq": "lymphocyte transmembrane adapter 1; membrane-associated adapter protein LAX", "tax_id": 10116, "disease": "", "pathway": " (rno:498232)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0046649 lymphocyte activation;GO:0006955 immune response;GO:0035556 intracellular signal transduction;GO:0042113 B cell activation;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVQ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FX52-1", "uniprot_id": [ { "id": "PLCZ1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FX52", "type": "external" } ], "mass": 74315.0, "length": 645, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1", "gene_name": "Plcz1", "organism": "Rat", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1", "refseq_ac": [ { "id": "NP_001012234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012234", "type": "external" } ], "gene_names_uniprotkb": "Plcz1", "gene_names_refseq": "Plcz1", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; 3.1.4.11; PLC-zeta-1; Phosphoinositide phospholipase C-zeta-1; Phospholipase C-zeta-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; PLC-zeta-1; phosphoinositide phospholipase C-zeta-1", "tax_id": 10116, "disease": "spermatogenic failure 17 (Disease Ontology:DOID:0070174)", "pathway": " (rno:497197); (R-RNO-1855204)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18322275", "class_list": "", "function": "All PLCZ1 proteins including fish could induce Ca(2+) oscillations in mouse eggs, but the activity was variable in the order of human >> mouse > medaka >> rat, estimated from minimal RNA concentration to induce Ca(2+) spikes., [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0004629 phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0061827 sperm head;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0035556 intracellular signal transduction;GO:0006816 calcium ion transport;GO:0016042 lipid catabolic process;GO:0007343 egg activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FX52-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I034-1", "uniprot_id": [ { "id": "CSTOS_RAT", "url": "https://www.uniprot.org/uniprot/Q5I034", "type": "external" } ], "mass": 30056.0, "length": 277, "protein_name": "Protein CUSTOS", "gene_name": "C12h12orf43; Custos", "organism": "Rat", "refseq_name": "protein CUSTOS", "refseq_ac": [ { "id": "NP_001009630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009630", "type": "external" } ], "gene_names_uniprotkb": "C12h12orf43; Custos", "gene_names_refseq": "C12h12orf43; C12orf43l; Custos; RGD1311899", "protein_names_uniprotkb": "Protein CUSTOS", "protein_names_refseq": "chromosome 12 open reading frame 43 like; protein CUSTOS; uncharacterized protein C12orf43 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:288704)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a role in the regulation of Wnt signaling pathway during early development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005730 nucleolus", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0060061 Spemann organizer formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I034-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0C5-1", "uniprot_id": [ { "id": "FMT_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0C5", "type": "external" } ], "mass": 42997.0, "length": 385, "protein_name": "Methionyl-tRNA formyltransferase, mitochondrial", "gene_name": "Mtfmt", "organism": "Rat", "refseq_name": "methionyl-tRNA formyltransferase, mitochondrial", "refseq_ac": [ { "id": "NP_001009697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009697", "type": "external" } ], "gene_names_uniprotkb": "Mtfmt", "gene_names_refseq": "Mtfmt; RGD1309462", "protein_names_uniprotkb": "Methionyl-tRNA formyltransferase, mitochondrial; 2.1.2.9; MtFMT", "protein_names_refseq": "methionyl-tRNA formyltransferase, mitochondrial", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 15 (Disease Ontology:DOID:0111491); nuclear type mitochondrial complex I deficiency 27 (Disease Ontology:DOID:0112090)", "pathway": " (rno:315763)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.9", "type": "external" } ], "go_molecular_function": "GO:0004479 methionyl-tRNA formyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0071951 conversion of methionyl-tRNA to N-formyl-methionyl-tRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0C5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0H3-1", "uniprot_id": [ { "id": "SUMO1_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0H3", "type": "external" } ], "mass": 11557.0, "length": 101, "protein_name": "Small ubiquitin-related modifier 1", "gene_name": "Sumo1", "organism": "Rat", "refseq_name": "small ubiquitin-related modifier 1", "refseq_ac": [ { "id": "NP_001009672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009672", "type": "external" } ], "gene_names_uniprotkb": "Sumo1; LOC120102380", "gene_names_refseq": "Sumo1", "protein_names_uniprotkb": "Small ubiquitin-related modifier 1; SUMO-1", "protein_names_refseq": "SMT3 suppressor of mif two 3 homolog 1; SUMO-1; small ubiquitin-related modifier 1; ubiquitin-like 1 (sentrin)", "tax_id": 10116, "disease": "orofacial cleft 10 (Disease Ontology:DOID:0080403); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:301442); (R-RNO-3065676); (R-RNO-3065678); (R-RNO-3065679); (R-RNO-3108214); (R-RNO-3232118); (R-RNO-3232142); (R-RNO-3899300); (R-RNO-4085377); (R-RNO-4090294); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-4655427); (R-RNO-4755510); (R-RNO-5693565); (R-RNO-5696395); (R-RNO-877312); (R-RNO-8866904); (R-RNO-9615933); (R-RNO-9793242); (R-RNO-9856649); (R-RNO-9937850)", "pathway_count": 23, "publication_count": 8, "publication_id_list": "16955485;22673903;25867063;25976847;26979866;28902364;31642335;35002525", "class_list": "", "function": "Activity-Induced SUMOylation of Neuronal Nitric Oxide Synthase Is Associated with Plasticity of Synaptic Transmission and Extracellular Signal-Regulated Kinase 1/2 Signaling., [RefSeq, PubMed]; C/EBPalpha played a role in lung development and provided the insight into the mechanism underlying SUMO-modification., [RefSeq, PubMed]; SUMO1 knockdown worsened ischemic damage and reduced the protective effect of preconditioning. NCX3 sumoylation participates in SUMO1 protective role during ischemic preconditioning., [RefSeq, PubMed]; SUMO1 may participate in the modulation of HIF1alpha through sumoylation in hypoxic pulmonary hypertension., [RefSeq, PubMed]; The cross-talk between PARylation and SUMOylation in C/EBPbeta at K134 site participates in pathological cardiac hypertrophy. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0015459 potassium channel regulator activity;GO:0031625 ubiquitin protein ligase binding;GO:1990381 ubiquitin-specific protease binding;GO:0044389 ubiquitin-like protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0030578 PML body organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation;GO:0006355 regulation of DNA-templated transcription;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5I0H3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0L7-1", "uniprot_id": [ { "id": "KTI12_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0L7", "type": "external" } ], "mass": 38358.0, "length": 350, "protein_name": "Protein KTI12 homolog", "gene_name": "Kti12", "organism": "Rat", "refseq_name": "protein KTI12 homolog", "refseq_ac": [ { "id": "NP_001037753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037753", "type": "external" } ], "gene_names_uniprotkb": "Kti12", "gene_names_refseq": "Kti12", "protein_names_uniprotkb": "Protein KTI12 homolog", "protein_names_refseq": "KTI12 chromatin associated homolog; KTI12 homolog, chromatin associated; protein KTI12 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:685656)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding", "go_cellular_component": "", "go_biological_process": "GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5I0L7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5KR61-1", "uniprot_id": [ { "id": "PIGV_RAT", "url": "https://www.uniprot.org/uniprot/Q5KR61", "type": "external" } ], "mass": 54701.0, "length": 492, "protein_name": "GPI alpha-1,6-mannosyltransferase 2", "gene_name": "Pigv", "organism": "Rat", "refseq_name": "GPI alpha-1,6-mannosyltransferase 2 isoform a", "refseq_ac": [ { "id": "NP_001010966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010966", "type": "external" } ], "gene_names_uniprotkb": "Pigv", "gene_names_refseq": "Pigv; RGD1309526", "protein_names_uniprotkb": "GPI alpha-1,6-mannosyltransferase 2; 2.4.1.-; GPI mannosyltransferase II; GPI-MT-II; PIG-V; Phosphatidylinositol-glycan biosynthesis class V protein", "protein_names_refseq": "GPI alpha-1,6-mannosyltransferase 2 isoform a; GPI alpha-1,6-mannosyltransferase 2; GPI mannosyltransferase 2; GPI mannosyltransferase II; GPI-MT-II; PIG-V; phosphatidylinositol glycan, class V; phosphatidylinositol-glycan biosynthesis class V protein", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); hyperphosphatasia with impaired intellectual development syndrome 1 (Disease Ontology:DOID:0070433); Diamond-Blackfan anemia 4 (Disease Ontology:DOID:0111890); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (rno:366478); (R-RNO-162710)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15623507", "class_list": "glycogene;glycosyltransferase", "function": "Alpha-1,6-mannosyltransferase that catalyzes the transfer of the second mannose, via an alpha-1,6 bond, from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H3) and participates in the seventh step of the glycosylphosphatidylinositol-anchor biosynthesis (PubMed:15623507). May also transfer the second mannose on a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H5), but less effectively (By similarity)., [UniProtKB, PubMed, UniProtKB]; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0000009 alpha-1,6-mannosyltransferase activity;GO:0120563 dol-P-Man:Man(1)GlcN-acyl-PI alpha-1,6-mannosyltransferase activity;GO:0004376 GPI mannosyltransferase activity", "go_cellular_component": "GO:0031501 mannosyltransferase complex;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5KR61-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M843-1", "uniprot_id": [ { "id": "OGFD3_RAT", "url": "https://www.uniprot.org/uniprot/Q5M843", "type": "external" } ], "mass": 35385.0, "length": 315, "protein_name": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3", "gene_name": "Ogfod3", "organism": "Rat", "refseq_name": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3", "refseq_ac": [ { "id": "NP_001013998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013998", "type": "external" } ], "gene_names_uniprotkb": "Ogfod3", "gene_names_refseq": "Ogfod3; RGD1305007", "protein_names_uniprotkb": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3; 1.14.11.-", "protein_names_refseq": "2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3; PKHD domain-containing transmembrane protein C17orf101 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:303749)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0051213 dioxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M843-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M872-1", "uniprot_id": [ { "id": "DPEP2_RAT", "url": "https://www.uniprot.org/uniprot/Q5M872", "type": "external" } ], "mass": 53285.0, "length": 481, "protein_name": "Dipeptidase 2", "gene_name": "Dpep2", "organism": "Rat", "refseq_name": "dipeptidase 2 precursor", "refseq_ac": [ { "id": "NP_001011928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011928", "type": "external" } ], "gene_names_uniprotkb": "Dpep2", "gene_names_refseq": "Dpep2", "protein_names_uniprotkb": "Dipeptidase 2; 3.4.13.19", "protein_names_refseq": "dipeptidase 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:291984); (R-RNO-2142691); (R-RNO-5423646)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) and cystinyl-bis-glycine., [UniProtKB, UniProtKB]; Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappa-B inflammatory signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.13.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.19", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008238 exopeptidase activity;GO:0070573 metallodipeptidase activity;GO:0016805 dipeptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006691 leukotriene metabolic process;GO:1901749 leukotriene D4 catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M872-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M8C6-1", "uniprot_id": [ { "id": "FGL1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M8C6", "type": "external" } ], "mass": 36476.0, "length": 314, "protein_name": "Fibrinogen-like protein 1", "gene_name": "Fgl1", "organism": "Rat", "refseq_name": "fibrinogen-like protein 1 precursor", "refseq_ac": [ { "id": "NP_742007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742007", "type": "external" } ], "gene_names_uniprotkb": "Fgl1", "gene_names_refseq": "Fgl1; Frep1; Lfire1", "protein_names_uniprotkb": "Fibrinogen-like protein 1", "protein_names_refseq": "fibrinogen-like protein 1 precursor; fibrinogen-like protein 1; fibrinogen-related protein 1; fibronigen-like protein 1; liver fibrinogen-related protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:246186)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18039467;25901902", "class_list": "", "function": "Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a ligand of LAG3. LAG3-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell activation. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The expression of FGL1 and p-STAT3 were elevated concurrently with the improvement of liver function., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0072574 hepatocyte proliferation;GO:0008203 cholesterol metabolic process;GO:0060612 adipose tissue development;GO:0007596 blood coagulation;GO:0010906 regulation of glucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5M8C6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPI4-1", "uniprot_id": [ { "id": "LAMP5_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPI4", "type": "external" } ], "mass": 31505.0, "length": 280, "protein_name": "Lysosome-associated membrane glycoprotein 5", "gene_name": "Lamp5", "organism": "Rat", "refseq_name": "lysosome-associated membrane glycoprotein 5 precursor", "refseq_ac": [ { "id": "NP_001014205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014205", "type": "external" } ], "gene_names_uniprotkb": "Lamp5", "gene_names_refseq": "BAD-LAMP; LAMP-5; Lamp5; RGD1306991", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 5; BAD-LAMP; Brain and dendritic cell-associated LAMP; Brain-associated LAMP-like protein; LAMP-5; Lysosome-associated membrane protein 5", "protein_names_refseq": "LAMP family protein C20orf103 homolog; brain and dendritic cell-associated LAMP; brain-associated LAMP-like protein; lysosomal-associated membrane protein family, member 5; lysosome-associated membrane glycoprotein 5 precursor; lysosome-associated membrane glycoprotein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:362220)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10.1039/D0MO00044B;34106099", "class_list": "", "function": "Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0099171 presynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5PPI4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPI7-1", "uniprot_id": [ { "id": "LHPL5_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPI7", "type": "external" } ], "mass": 24186.0, "length": 219, "protein_name": "LHFPL tetraspan subfamily member 5 protein", "gene_name": "Lhfpl5", "organism": "Rat", "refseq_name": "LHFPL tetraspan subfamily member 5 protein", "refseq_ac": [ { "id": "NP_001013928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013928", "type": "external" } ], "gene_names_uniprotkb": "Lhfpl5; Tmhs", "gene_names_refseq": "Lhfpl5; Tmhs", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 5 protein; Lipoma HMGIC fusion partner-like 5 protein; Tetraspan membrane protein of hair cell stereocilia", "protein_names_refseq": "LHFPL tetraspan subfamily member 5 protein; lipoma HMGIC fusion partner-like 5 protein; tetraspan membrane protein of hair cell stereocilia; tetraspan transmembrane protein, hair cell stereocilia", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 67 (Disease Ontology:DOID:0110518)", "pathway": " (rno:294303)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16752389", "class_list": "", "function": "Auxiliary subunit of the mechanotransducer (MET) non-specific cation channel complex located at the tips of the shorter stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. Functionally couples PCDH15 to the transduction channel., [UniProtKB, UniProtKB]; LHFPL5 is essential for normal function of the human cochlea., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0032426 stereocilium tip;GO:0032421 stereocilium bundle", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0007605 sensory perception of sound;GO:0050974 detection of mechanical stimulus involved in sensory perception;GO:0060088 auditory receptor cell stereocilium organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PPI7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPL3-1", "uniprot_id": [ { "id": "NSDHL_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPL3", "type": "external" } ], "mass": 40412.0, "length": 362, "protein_name": "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "gene_name": "Nsdhl", "organism": "Rat", "refseq_name": "sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "refseq_ac": [ { "id": "NP_001009399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009399", "type": "external" } ], "gene_names_uniprotkb": "Nsdhl", "gene_names_refseq": "Nsdhl", "protein_names_uniprotkb": "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; 1.1.1.170", "protein_names_refseq": "NAD(P) dependent steroid dehydrogenase-like; sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating", "tax_id": 10116, "disease": "X-linked chondrodysplasia punctata 1 (Disease Ontology:DOID:0060292); CHILD syndrome (Disease Ontology:DOID:0111822); CK syndrome (Disease Ontology:DOID:0111898); Bloch-Sulzberger syndrome (Disease Ontology:DOID:12305); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:309262); (R-RNO-6807047); (R-RNO-6807062)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Catalyzes the NAD(P)(+)-dependent oxidative decarboxylation of the C4 methyl groups of 4-alpha-carboxysterols in post-squalene cholesterol biosynthesis. Also plays a role in the regulation of the endocytic trafficking of EGFR., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.170", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.170", "type": "external" } ], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0000252 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity;GO:0102175 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0001942 hair follicle development;GO:0060716 labyrinthine layer blood vessel development;GO:0007224 smoothened signaling pathway;GO:0033489 cholesterol biosynthetic process via desmosterol", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5PPL3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQJ6-1", "uniprot_id": [ { "id": "P5CR3_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQJ6", "type": "external" } ], "mass": 28878.0, "length": 274, "protein_name": "Pyrroline-5-carboxylate reductase 3", "gene_name": "Eef1d; Pycr3", "organism": "Rat", "refseq_name": "pyrroline-5-carboxylate reductase 3", "refseq_ac": [ { "id": "NP_001011993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011993", "type": "external" } ], "gene_names_uniprotkb": "Eef1d; Pycr3; Eef1d; Pycr3; Pycrl", "gene_names_refseq": "Pycr3; Pycrl", "protein_names_uniprotkb": "Pyrroline-5-carboxylate reductase 3; 1.5.1.2; P5C reductase 3; P5CR 3; Pyrroline-5-carboxylate reductase-like protein", "protein_names_refseq": "P5C reductase 3; P5CR 3; pyrroline-5-carboxylate reductase 3; pyrroline-5-carboxylate reductase-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:300035); (R-RNO-8964539)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H. Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0004735 pyrroline-5-carboxylate reductase activity;GO:0042802 identical protein binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm;GO:0005853 eukaryotic translation elongation factor 1 complex;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0055129 L-proline biosynthetic process;GO:0071479 cellular response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQJ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQQ7-1", "uniprot_id": [ { "id": "LIX1L_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQQ7", "type": "external" } ], "mass": 36663.0, "length": 338, "protein_name": "LIX1-like protein", "gene_name": "Lix1l", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lix1l", "gene_names_refseq": "", "protein_names_uniprotkb": "LIX1-like protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0030036 actin cytoskeleton organization;GO:0003174 mitral valve development;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQQ7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQT7-1", "uniprot_id": [ { "id": "PHLA3_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQT7", "type": "external" } ], "mass": 13735.0, "length": 125, "protein_name": "Pleckstrin homology-like domain family A member 3", "gene_name": "Phlda3", "organism": "Rat", "refseq_name": "pleckstrin homology-like domain family A member 3", "refseq_ac": [ { "id": "NP_001012206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012206", "type": "external" } ], "gene_names_uniprotkb": "Phlda3; Tih1", "gene_names_refseq": "Phlda3", "protein_names_uniprotkb": "Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1", "protein_names_refseq": "TDAG51/Ipl homolog 1; pleckstrin homology-like domain family A member 3", "tax_id": 10116, "disease": "", "pathway": " (rno:363989)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "31426686;34351043", "class_list": "", "function": "Novel Role for Pleckstrin Homology-Like Domain Family A, Member 3 in the Regulation of Pathological Cardiac Hypertrophy., [RefSeq, PubMed]; PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis., [RefSeq, PubMed]; p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5PQT7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63663-1", "uniprot_id": [ { "id": "GBP2_RAT", "url": "https://www.uniprot.org/uniprot/Q63663", "type": "external" } ], "mass": 67109.0, "length": 589, "protein_name": "Guanylate-binding protein 2", "gene_name": "Gbp2", "organism": "Rat", "refseq_name": "guanylate-binding protein 2", "refseq_ac": [ { "id": "NP_598308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598308", "type": "external" } ], "gene_names_uniprotkb": "Gbp2", "gene_names_refseq": "Gbp2", "protein_names_uniprotkb": "Guanylate-binding protein 2; 3.6.5.-; GBP-2; GTP-binding protein 2; Guanine nucleotide-binding protein 2; Interferon-induced guanylate-binding protein 2; p67", "protein_names_refseq": "GBP-2; GTP-binding protein 2; guanine nucleotide-binding protein 2; guanylate binding protein 2, interferon-inducible; guanylate nucleotide binding protein 2; guanylate-binding protein 1; guanylate-binding protein 2; interferon-induced guanylate-binding protein 2; isoprenylated 67 kDa protein; p67", "tax_id": 10116, "disease": "", "pathway": " (rno:171164); (R-RNO-9953170)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "28239766;29393594;8148370", "class_list": "", "function": "Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol. Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome. Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity by inhibiting FURIN-mediated maturation of viral envelope proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Neuronal cells overexpressing GBP2 exhibited up-regulation of GBP2 in the cerebral cortex following traumatic brain injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0140678 molecular function inhibitor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0044406 adhesion of symbiont to host;GO:0050830 defense response to Gram-positive bacterium;GO:0051607 defense response to virus;GO:0006605 protein targeting;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63663-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QJC9-1", "uniprot_id": [ { "id": "BAG5_RAT", "url": "https://www.uniprot.org/uniprot/Q5QJC9", "type": "external" } ], "mass": 51030.0, "length": 447, "protein_name": "BAG family molecular chaperone regulator 5", "gene_name": "Bag5", "organism": "Rat", "refseq_name": "BAG family molecular chaperone regulator 5", "refseq_ac": [ { "id": "NP_001008526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008526", "type": "external" } ], "gene_names_uniprotkb": "Bag5", "gene_names_refseq": "Bag5l1; Bag5", "protein_names_uniprotkb": "BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5", "protein_names_refseq": "BAG family molecular chaperone regulator 5; BAG-5; BCL2-associated athanogene 5-like 1; BCL2-associated athanogene 5; bcl-2-associated athanogene 5", "tax_id": 10116, "disease": "dilated cardiomyopathy 2F (Disease Ontology:DOID:0081162)", "pathway": " (rno:366734); (R-RNO-3371453)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15603737;23146300;26729625;31922242", "class_list": "", "function": "BAG5 enhances dopamine neuron death in a rat model of Parkinson's disease, whereas a mutant that inhibits BAG5 activity attenuates dopaminergic neurodegeneration., [RefSeq, PubMed]; BAG5 induction inhibits MPP(+)-induced apoptosis through both endogenous and mitochondria-mediated pathways of apoptosis., [RefSeq, PubMed]; Bag5 protein expression is significantly increased in the ER during ER stress and that this in turn modulates GRP78 protein stability and reduces ER stress., [RefSeq, PubMed]; Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (By similarity). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (PubMed:15603737)., [UniProtKB, PubMed, UniProtKB]; MiR155 inhibition represents a potential valuable regulator in mitigating myocardial hypoxia/reoxygenation injury through targeting BAG5 and MAPK/JNK signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0010977 negative regulation of neuron projection development;GO:0050821 protein stabilization;GO:0031397 negative regulation of protein ubiquitination;GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5QJC9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJR8-1", "uniprot_id": [ { "id": "LRC59_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJR8", "type": "external" } ], "mass": 34869.0, "length": 307, "protein_name": "Leucine-rich repeat-containing protein 59", "gene_name": "Lrrc59", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 59", "refseq_ac": [ { "id": "NP_001008281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008281", "type": "external" } ], "gene_names_uniprotkb": "Lrrc59; Rbp34", "gene_names_refseq": "Lrrc59", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 59; Protein p34", "protein_names_refseq": "leucine-rich repeat-containing protein 59; protein p34", "tax_id": 10116, "disease": "", "pathway": " (rno:287633)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "38843836;7690545", "class_list": "", "function": "Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63742", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0042645 mitochondrial nucleoid;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5RJR8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RK09-1", "uniprot_id": [ { "id": "EIF3G_RAT", "url": "https://www.uniprot.org/uniprot/Q5RK09", "type": "external" } ], "mass": 35651.0, "length": 320, "protein_name": "Eukaryotic translation initiation factor 3 subunit G", "gene_name": "Eif3g", "organism": "Rat", "refseq_name": "eukaryotic translation initiation factor 3 subunit G", "refseq_ac": [ { "id": "NP_001013113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013113", "type": "external" } ], "gene_names_uniprotkb": "Eif3g; EIF3G; EIF3S4; Eif3s4", "gene_names_refseq": "Eif3g; Eif3s4; eIF3 p42; eIF3 p44", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit G; Eukaryotic translation initiation factor 3 RNA-binding subunit; Eukaryotic translation initiation factor 3 subunit 4; eIF-3 RNA-binding subunit; eIF-3-delta; eIF3 p42; eIF3 p44; eIF3g", "protein_names_refseq": "eIF-3 RNA-binding subunit; eIF-3-delta; eukaryotic translation initiation factor 3 RNA-binding subunit; eukaryotic translation initiation factor 3 subunit 4; eukaryotic translation initiation factor 3 subunit G; eukaryotic translation initiation factor 3, subunit 4 (delta)", "tax_id": 10116, "disease": "", "pathway": " (rno:298700); (R-RNO-156827); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RK09-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKH6-1", "uniprot_id": [ { "id": "OS9_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKH6", "type": "external" } ], "mass": 75365.0, "length": 666, "protein_name": "Protein OS-9", "gene_name": "Os9", "organism": "Rat", "refseq_name": "protein OS-9 precursor", "refseq_ac": [ { "id": "NP_001007266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007266", "type": "external" } ], "gene_names_uniprotkb": "Os9", "gene_names_refseq": "Os-9; Os9", "protein_names_uniprotkb": "Protein OS-9", "protein_names_refseq": "amplified in osteosarcoma; osteosarcoma amplified 9, endoplasmic reticulum lectin; protein OS-9 precursor; protein OS-9", "tax_id": 10116, "disease": "", "pathway": " (rno:362891); (R-RNO-382556); (R-RNO-5358346); (R-RNO-9931269)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "12093806;19084021;21186601", "class_list": "", "function": "Characterized alternatively spliced form and found that only the non-spliced form binds to meprin beta, suggesting the possible mechanism of the regulation of OS-9 function., [RefSeq, PubMed]; HIF-1alpha, procollagen-proline dioxygenases and OS-9 are all involved in the pathogenesis of hypoxic pulmonary hypertension in rats., [RefSeq, PubMed]; Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 as well as hyperglycosylated HSP90B1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0030246 carbohydrate binding;GO:0140032 glycosylation-dependent protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0000836 Hrd1p ubiquitin ligase complex", "go_biological_process": "GO:0006605 protein targeting;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5RKH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1W7-1", "uniprot_id": [ { "id": "EMC9_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1W7", "type": "external" } ], "mass": 22941.0, "length": 206, "protein_name": "ER membrane protein complex subunit 9", "gene_name": "Emc9", "organism": "Rat", "refseq_name": "ER membrane protein complex subunit 9", "refseq_ac": [ { "id": "NP_001008297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008297", "type": "external" } ], "gene_names_uniprotkb": "Emc9; Fam158a", "gene_names_refseq": "Emc9; Fam158a; RGD1308113", "protein_names_uniprotkb": "ER membrane protein complex subunit 9; Protein FAM158A", "protein_names_refseq": "ER membrane protein complex subunit 9; UPF0172 protein FAM158A; family with sequence similarity 158, member A", "tax_id": 10116, "disease": "", "pathway": " (rno:290224)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U1W7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2N8-1", "uniprot_id": [ { "id": "IFT56_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2N8", "type": "external" } ], "mass": 64135.0, "length": 554, "protein_name": "Intraflagellar transport protein 56", "gene_name": "Ift56", "organism": "Rat", "refseq_name": "intraflagellar transport protein 56", "refseq_ac": [ { "id": "NP_001020216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020216", "type": "external" } ], "gene_names_uniprotkb": "Ift56; Ttc26", "gene_names_refseq": "Ift56; Ttc26", "protein_names_uniprotkb": "Intraflagellar transport protein 56; TPR repeat protein 26; Tetratricopeptide repeat protein 26", "protein_names_refseq": "TPR repeat protein 26; intraflagellar transport protein 56; tetratricopeptide repeat domain 26; tetratricopeptide repeat protein 26", "tax_id": 10116, "disease": "", "pathway": " (rno:500086); (R-RNO-5620924)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22718903", "class_list": "", "function": "Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0120170 intraciliary transport particle B binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0036064 ciliary basal body;GO:0097546 ciliary base;GO:0030991 intraciliary transport particle A", "go_biological_process": "GO:0015031 protein transport;GO:0007286 spermatid development;GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:0035735 intraciliary transport involved in cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2N8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2T4-1", "uniprot_id": [ { "id": "FIBIN_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2T4", "type": "external" } ], "mass": 24754.0, "length": 217, "protein_name": "Fin bud initiation factor homolog", "gene_name": "Fibin", "organism": "Rat", "refseq_name": "fin bud initiation factor homolog precursor", "refseq_ac": [ { "id": "NP_001020213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020213", "type": "external" } ], "gene_names_uniprotkb": "Fibin", "gene_names_refseq": "Fibin", "protein_names_uniprotkb": "Fin bud initiation factor homolog", "protein_names_refseq": "fin bud initiation factor homolog precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:499856)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2T4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2T6-1", "uniprot_id": [ { "id": "PLAG1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2T6", "type": "external" } ], "mass": 55640.0, "length": 499, "protein_name": "Zinc finger protein PLAG1", "gene_name": "Plag1", "organism": "Rat", "refseq_name": "zinc finger protein PLAG1 isoform a", "refseq_ac": [ { "id": "NP_001008317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008317", "type": "external" } ], "gene_names_uniprotkb": "Plag1", "gene_names_refseq": "Plag1", "protein_names_uniprotkb": "Zinc finger protein PLAG1; Pleiomorphic adenoma gene 1 protein", "protein_names_refseq": "pleiomorphic adenoma gene 1 protein; zinc finger protein PLAG1 isoform a; zinc finger protein PLAG1", "tax_id": 10116, "disease": "Silver-Russell syndrome (Disease Ontology:DOID:14681); pleomorphic adenoma (Disease Ontology:DOID:452)", "pathway": " (rno:297804)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36201855", "class_list": "", "function": "PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/beta-Catenin Signalling Pathway., [RefSeq, PubMed]; Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Cooperates with CBFB-MYH11 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2T6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2V4-1", "uniprot_id": [ { "id": "LYLAP_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2V4", "type": "external" } ], "mass": 63027.0, "length": 550, "protein_name": "Lysosomal leucine aminopeptidase", "gene_name": "Plbd1", "organism": "Rat", "refseq_name": "lysosomal leucine aminopeptidase precursor", "refseq_ac": [ { "id": "NP_001013949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013949", "type": "external" } ], "gene_names_uniprotkb": "Plbd1", "gene_names_refseq": "LyLAP; Plbd1; RGD1308734", "protein_names_uniprotkb": "Lysosomal leucine aminopeptidase; 3.4.11.-; LAMA-like protein 1; Lamina ancestor homolog 1; LyLAP; Phospholipase B domain-containing protein 1; Phospholipase B-like 1", "protein_names_refseq": "LAMA-like protein 1; lamina ancestor homolog 1; lysosomal leucine aminopeptidase precursor; lysosomal leucine aminopeptidase; phospholipase B domain-containing protein 1; putative phospholipase B-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:297694); (R-RNO-1482788); (R-RNO-1482839); (R-RNO-1482922); (R-RNO-1483115)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "21454685", "class_list": "", "function": "Lysosomal processive monoaminopeptidase that preferentially cleaves hydrophobic amino acids, with strong preference for leucine residues. Plays a key role in the degradation of hydrophobic transmembrane domains within the lysosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:1905146 lysosomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2V4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2V5-1", "uniprot_id": [ { "id": "CRLS1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2V5", "type": "external" } ], "mass": 32628.0, "length": 302, "protein_name": "Cardiolipin synthase (CMP-forming)", "gene_name": "Crls1", "organism": "Rat", "refseq_name": "cardiolipin synthase (CMP-forming)", "refseq_ac": [ { "id": "NP_001014280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014280", "type": "external" } ], "gene_names_uniprotkb": "Crls1", "gene_names_refseq": "Crls1; RGD1311037", "protein_names_uniprotkb": "Cardiolipin synthase (CMP-forming); 2.7.8.41; CLS", "protein_names_refseq": "CLS; cardiolipin synthase (CMP-forming); cardiolipin synthetase", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 57 (Disease Ontology:DOID:0070430)", "pathway": " (rno:366196); (R-RNO-1482925); (R-RNO-1483076)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "18454555;29325722", "class_list": "", "function": "CL has roles in in neuronal signaling, mitochondrial bioenergetics, and apoptosis, [RefSeq, PubMed]; Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Knock-down of cardiolipin synthase affected the cellular CL content in the presence of linoleic acid (LA) in the culture medium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.41", "type": "external" } ], "go_molecular_function": "GO:0043337 cardiolipin synthase (CMP-forming)", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0016020 membrane", "go_biological_process": "GO:0097068 response to thyroxine;GO:1905711 response to phosphatidylethanolamine;GO:0032049 cardiolipin biosynthetic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U2V5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2V8-1", "uniprot_id": [ { "id": "EMC3_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2V8", "type": "external" } ], "mass": 29980.0, "length": 261, "protein_name": "ER membrane protein complex subunit 3", "gene_name": "Emc3", "organism": "Rat", "refseq_name": "ER membrane protein complex subunit 3", "refseq_ac": [ { "id": "NP_001008356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008356", "type": "external" } ], "gene_names_uniprotkb": "Emc3; Tmem111", "gene_names_refseq": "Emc3; Pob; RGD1311566; Tmem111", "protein_names_uniprotkb": "ER membrane protein complex subunit 3; Transmembrane protein 111", "protein_names_refseq": "30 kDa protein; ER membrane protein complex subunit 3; partial optokinetic response b; transmembrane protein 111", "tax_id": 10116, "disease": "intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (rno:312640); (R-RNO-8980692)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2V8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5VJS5-1", "uniprot_id": [ { "id": "DAAF4_RAT", "url": "https://www.uniprot.org/uniprot/Q5VJS5", "type": "external" } ], "mass": 48119.0, "length": 420, "protein_name": "Dynein axonemal assembly factor 4", "gene_name": "Dnaaf4", "organism": "Rat", "refseq_name": "dynein axonemal assembly factor 4", "refseq_ac": [ { "id": "NP_001007011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007011", "type": "external" } ], "gene_names_uniprotkb": "Dnaaf4; Dyx1c1; Ekn1", "gene_names_refseq": "Dnaaf4; Dyx1c1; Edem2; Ekn1", "protein_names_uniprotkb": "Dynein axonemal assembly factor 4; Dyslexia susceptibility 1 candidate gene 1 protein homolog", "protein_names_refseq": "dynein assembly factor 4, axonemal; dynein axonemal assembly factor 4; dyslexia susceptibility 1 candidate 1 homolog; dyslexia susceptibility 1 candidate gene 1 protein homolog", "tax_id": 10116, "disease": "Robinow syndrome (Disease Ontology:DOID:0060254); primary ciliary dyskinesia 25 (Disease Ontology:DOID:0110615); sensorineural hearing loss (Disease Ontology:DOID:10003); dyslexia (Disease Ontology:DOID:4428)", "pathway": " (rno:363096)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16989952;19423554;20977651;21070838;23594585", "class_list": "", "function": "DYX1C1 comlexes with ERalpha or ERbeta at endogenous levels along neurites of primary rat hippocampal neurons., [RefSeq, PubMed]; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Study describes the impact of Dyx1c1 on behavioral functions similar to those affected in language-impaired populations as well as information about changes to the brain following early disruption of this candidate dyslexia susceptibility gene, [RefSeq, PubMed]; These results provide further support for the role of Dyx1c1 in neuronal migration and working memory, [RefSeq, PubMed]; Transfection with Dyx1c1 small hairpin shRNA results from both cell autonomous and non-cell autonomous effects. There is no evidence to support non-cell autonomous disruption of neuronal position in the cerebral cortex itself., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0007507 heart development;GO:0007611 learning or memory;GO:0001764 neuron migration;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q5VJS5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI63-1", "uniprot_id": [ { "id": "KIFC1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI63", "type": "external" } ], "mass": 76141.0, "length": 693, "protein_name": "Kinesin-like protein KIFC1", "gene_name": "Kifc1", "organism": "Rat", "refseq_name": "kinesin-like protein KIFC1", "refseq_ac": [ { "id": "NP_001005878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005878", "type": "external" } ], "gene_names_uniprotkb": "Kifc1; Krp1", "gene_names_refseq": "Kifc1", "protein_names_uniprotkb": "Kinesin-like protein KIFC1; Kinesin-related protein 1", "protein_names_refseq": "kinesin-like protein KIFC1; kinesin-related protein 1; kinesin-related protein KRP1", "tax_id": 10116, "disease": "", "pathway": " (rno:294286); (R-RNO-6811434); (R-RNO-983189)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12826589;29393594;30804089;8688559", "class_list": "", "function": "KIFC1, perhaps in association with nuclear factors, assists in the formation and/or elongation of the spermatid acrosome, [RefSeq, PubMed]; Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study shows that KIFC1, a molecular motor well characterized in mitosis, is robustly expressed in neurons, where it has profound influence on the organization of microtubules in a number of different functional contexts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O54719", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0008569 minus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0072382 minus-end-directed vesicle transport along microtubule;GO:0007283 spermatogenesis;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5XI63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI68-1", "uniprot_id": [ { "id": "NC2B_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI68", "type": "external" } ], "mass": 19430.0, "length": 176, "protein_name": "Protein Dr1", "gene_name": "Dr1", "organism": "Rat", "refseq_name": "protein Dr1", "refseq_ac": [ { "id": "NP_001011914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011914", "type": "external" } ], "gene_names_uniprotkb": "Dr1", "gene_names_refseq": "Dr1", "protein_names_uniprotkb": "Protein Dr1; Down-regulator of transcription 1; NC2-beta; Negative cofactor 2-beta; TATA-binding protein-associated phosphoprotein", "protein_names_refseq": "NC2-beta; TATA-binding protein-associated phosphoprotein; down-regulator of transcription 1, TBP-binding (negative cofactor 2); negative cofactor 2-beta; protein Dr1-like; protein Dr1", "tax_id": 10116, "disease": "", "pathway": " (rno:289881); (R-RNO-9772755)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "36197015", "class_list": "", "function": "DR1-CSE/H2S pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose., [RefSeq, PubMed]; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0017025 TBP-class protein binding;GO:0016251 RNA polymerase II general transcription initiation factor activity;GO:0140223 general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0017054 negative cofactor 2 complex;GO:0140672 ATAC complex", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI68-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI69-1", "uniprot_id": [ { "id": "DHX40_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI69", "type": "external" } ], "mass": 88514.0, "length": 779, "protein_name": "Probable ATP-dependent RNA helicase DHX40", "gene_name": "Dhx40", "organism": "Rat", "refseq_name": "probable ATP-dependent RNA helicase DHX40", "refseq_ac": [ { "id": "NP_001005873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005873", "type": "external" } ], "gene_names_uniprotkb": "Dhx40", "gene_names_refseq": "Dhx40", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DHX40; 3.6.4.13; DEAH box protein 40", "protein_names_refseq": "DEAH (Asp-Glu-Ala-His) box polypeptide 40; DEAH box protein 40; probable ATP-dependent RNA helicase DHX40", "tax_id": 10116, "disease": "", "pathway": " (rno:287595)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable ATP-dependent RNA helicase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0034458 3'-5' RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI69-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI73-1", "uniprot_id": [ { "id": "GDIR1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI73", "type": "external" } ], "mass": 23407.0, "length": 204, "protein_name": "Rho GDP-dissociation inhibitor 1", "gene_name": "Arhgdia", "organism": "Rat", "refseq_name": "rho GDP-dissociation inhibitor 1", "refseq_ac": [ { "id": "NP_001007006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007006", "type": "external" } ], "gene_names_uniprotkb": "Arhgdia", "gene_names_refseq": "Arhgdia; Bles01; Rho GDI 1", "protein_names_uniprotkb": "Rho GDP-dissociation inhibitor 1; Rho GDI 1; Rho-GDI alpha", "protein_names_refseq": "Rho GDP dissociation inhibitor (GDI) alpha; rho GDP-dissociation inhibitor 1; rho-GDI alpha", "tax_id": 10116, "disease": "nephrotic syndrome type 8 (Disease Ontology:DOID:0080389); hypertension (Disease Ontology:DOID:10763); nephrotic syndrome (Disease Ontology:DOID:1184)", "pathway": " (rno:360678); (R-RNO-193634); (R-RNO-209563); (R-RNO-8980692); (R-RNO-9013106); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013407); (R-RNO-9013408)", "pathway_count": 10, "publication_count": 12, "publication_id_list": "17506542;19103160;19343716;20696765;22673903;25961457;26593060;26971292;27841340;31029634;34502162;35080740", "class_list": "", "function": "A direct interaction between RhoGDIalpha/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia., [RefSeq, PubMed]; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; EIF5A1 upregulates RhoGDIalpha to promote neuroplasticity caudal to the spinal cord injury and functional recovery after spinal cord injury. Publication Status: Online-Only, [RefSeq, PubMed]; Results show that RhoGDIalpha is transcriptionally regulated by ATF4 in neurons and that RhoGDIalpha knockown reduces Cdc42 expression supporting the view that RhoGDIalpha mediates the effects of ATF4 on Cdc42 and therefore on mushroom spines and excitatory synapses. Publication Status: Online-Only, [RefSeq, PubMed]; Rho GDP dissociation inhibitor alpha silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling, [RefSeq, PubMed]; The siRNA-mediated suppression of expression of alphaGDI especially affected vesicle dynamics., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005094 Rho GDP-dissociation inhibitor activity;GO:0005096 GTPase activator activity;GO:0005504 fatty acid binding;GO:0019901 protein kinase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0071461 cellular response to redox state;GO:0097338 response to clozapine;GO:0071526 semaphorin-plexin signaling pathway;GO:0030336 negative regulation of cell migration;GO:0007266 Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q5XI73-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI79-1", "uniprot_id": [ { "id": "NDUF7_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI79", "type": "external" } ], "mass": 48716.0, "length": 436, "protein_name": "Protein arginine methyltransferase NDUFAF7, mitochondrial", "gene_name": "Ndufaf7", "organism": "Rat", "refseq_name": "protein arginine methyltransferase NDUFAF7, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001008319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008319", "type": "external" } ], "gene_names_uniprotkb": "Ndufaf7", "gene_names_refseq": "Ndufaf7; RGD1311578", "protein_names_uniprotkb": "Protein arginine methyltransferase NDUFAF7, mitochondrial; 2.1.1.320; NADH dehydrogenase [ubiquinone] complex I, assembly factor 7; Protein midA homolog", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 7; NADH dehydrogenase [ubiquinone] complex I, assembly factor 7; protein arginine methyltransferase NDUFAF7, mitochondrial precursor; protein arginine methyltransferase NDUFAF7, mitochondrial; protein midA homolog, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:298748); (R-RNO-6799198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0035243 protein-arginine omega-N symmetric methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI79-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI99-1", "uniprot_id": [ { "id": "LAMP3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI99", "type": "external" } ], "mass": 44388.0, "length": 408, "protein_name": "Lysosome-associated membrane glycoprotein 3", "gene_name": "Lamp3", "organism": "Rat", "refseq_name": "lysosome-associated membrane glycoprotein 3 precursor", "refseq_ac": [ { "id": "NP_001012015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012015", "type": "external" } ], "gene_names_uniprotkb": "Lamp3", "gene_names_refseq": "Lamp3", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 3; LAMP-3; Lysosomal-associated membrane protein 3", "protein_names_refseq": "LAMP-3; lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3 precursor; lysosome-associated membrane glycoprotein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:303801)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0006629 lipid metabolic process;GO:0010506 regulation of autophagy;GO:0010628 positive regulation of gene expression;GO:0043129 surfactant homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI99-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIA8-1", "uniprot_id": [ { "id": "GHITM_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIA8", "type": "external" } ], "mass": 37178.0, "length": 346, "protein_name": "Growth hormone-inducible transmembrane protein", "gene_name": "Ghitm", "organism": "Rat", "refseq_name": "growth hormone-inducible transmembrane protein", "refseq_ac": [ { "id": "NP_001005908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005908", "type": "external" } ], "gene_names_uniprotkb": "Ghitm; Mics1", "gene_names_refseq": "Ghitm; MICS1", "protein_names_uniprotkb": "Growth hormone-inducible transmembrane protein; MICS1; Mitochondrial morphology and cristae structure 1", "protein_names_refseq": "growth hormone-inducible transmembrane protein; mitochondrial morphology and cristae structure 1", "tax_id": 10116, "disease": "", "pathway": " (rno:290596)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (By similarity). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Required for the mitochondrial tubular network and cristae organization (By similarity). Involved in apoptotic release of cytochrome c (By similarity). Inhibits AFG3L2 proteolytic activity, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (By similarity). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the proteome (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015369 calcium:proton antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006915 apoptotic process;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0090201 negative regulation of release of cytochrome c from mitochondria;GO:0099093 calcium export from the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIA8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIG4-1", "uniprot_id": [ { "id": "OCAD1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIG4", "type": "external" } ], "mass": 27659.0, "length": 247, "protein_name": "OCIA domain-containing protein 1", "gene_name": "Ociad1", "organism": "Rat", "refseq_name": "OCIA domain-containing protein 1", "refseq_ac": [ { "id": "NP_001013896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013896", "type": "external" } ], "gene_names_uniprotkb": "Ociad1; Asrij", "gene_names_refseq": "Ociad1", "protein_names_uniprotkb": "OCIA domain-containing protein 1", "protein_names_refseq": "OCIA domain-containing protein 1; ovarian carcinoma immunoreactive antigen", "tax_id": 10116, "disease": "", "pathway": " (rno:289590)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity)., [UniProtKB, UniProtKB]; Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome", "go_biological_process": "GO:2000736 regulation of stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XIG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIH4-1", "uniprot_id": [ { "id": "LIAS_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIH4", "type": "external" } ], "mass": 41874.0, "length": 373, "protein_name": "Lipoyl synthase, mitochondrial", "gene_name": "Lias", "organism": "Rat", "refseq_name": "lipoyl synthase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001012037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012037", "type": "external" } ], "gene_names_uniprotkb": "Lias; LIAS", "gene_names_refseq": "Lias", "protein_names_uniprotkb": "Lipoyl synthase, mitochondrial; 2.8.1.8; LS; Lip-syn; Lipoate synthase; Lipoic acid synthase", "protein_names_refseq": "LS; lip-syn; lipoate synthase; lipoic acid synthase; lipoyl synthase, mitochondrial precursor; lipoyl synthase, mitochondrial", "tax_id": 10116, "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649)", "pathway": " (rno:305348); (R-RNO-9857492)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.8", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016992 lipoate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006954 inflammatory response;GO:0006979 response to oxidative stress;GO:0032496 response to lipopolysaccharide;GO:0001843 neural tube closure;GO:0009249 protein lipoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIH4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIJ8-1", "uniprot_id": [ { "id": "DRC2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIJ8", "type": "external" } ], "mass": 59004.0, "length": 502, "protein_name": "Dynein regulatory complex subunit 2", "gene_name": "Drc2", "organism": "Rat", "refseq_name": "dynein regulatory complex subunit 2", "refseq_ac": [ { "id": "NP_001014225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014225", "type": "external" } ], "gene_names_uniprotkb": "Drc2; Ccdc65", "gene_names_refseq": "Ccdc65; Drc2", "protein_names_uniprotkb": "Dynein regulatory complex subunit 2; Coiled-coil domain-containing protein 65", "protein_names_refseq": "coiled-coil domain containing 65; coiled-coil domain-containing protein 65; dynein regulatory complex subunit 2", "tax_id": 10116, "disease": "primary ciliary dyskinesia 27 (Disease Ontology:DOID:0110611)", "pathway": " (rno:362994)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031514 motile cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0005858 axonemal dynein complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0007420 brain development;GO:0045184 establishment of protein localization;GO:0060271 cilium assembly;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIJ8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIN6-1", "uniprot_id": [ { "id": "LETM1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIN6", "type": "external" } ], "mass": 83060.0, "length": 739, "protein_name": "Mitochondrial proton/calcium exchanger protein", "gene_name": "Letm1", "organism": "Rat", "refseq_name": "mitochondrial proton/calcium exchanger protein precursor", "refseq_ac": [ { "id": "NP_001005884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005884", "type": "external" } ], "gene_names_uniprotkb": "Letm1", "gene_names_refseq": "KHE; Letm1", "protein_names_uniprotkb": "Mitochondrial proton/calcium exchanger protein; Electroneutral mitochondrial K(+)/H(+)exchanger; KHE; Leucine zipper-EF-hand-containing transmembrane protein 1", "protein_names_refseq": "LETM1 and EF-hand domain-containing protein 1, mitochondrial; electroneutral mitochondrial K(+)/H(+)exchanger; leucine zipper-EF-hand-containing transmembrane protein 1; mitochondrial proton/calcium exchanger protein precursor; mitochondrial proton/calcium exchanger protein", "tax_id": 10116, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:305457); (R-RNO-9013408)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18628306;23645710;25077561", "class_list": "", "function": "Letm1 expression is decreased in patients with intractable TLE and a rat model of epilepsy. Down-regulation of Letm1 leads to increases mitochondrial swelling and decreased MT-CYB expression, which is associated with susceptibility to seizures., [RefSeq, PubMed]; Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (By similarity). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). Essential for early embryonic development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics Erratum:[FASEB J. 2015 Aug;29(8):3593. doi: 10.1096/fj.14-256453ERR. PMID: 26232296], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0043022 ribosome binding;GO:0015369 calcium:proton antiporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0051562 negative regulation of mitochondrial calcium ion concentration;GO:0051260 protein homooligomerization;GO:0006816 calcium ion transport;GO:0007005 mitochondrion organization;GO:0006851 mitochondrial calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5XIN6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIN7-1", "uniprot_id": [ { "id": "PMGT1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIN7", "type": "external" } ], "mass": 75148.0, "length": 660, "protein_name": "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "gene_name": "Pomgnt1", "organism": "Rat", "refseq_name": "protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "refseq_ac": [ { "id": "NP_001007748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007748", "type": "external" } ], "gene_names_uniprotkb": "Pomgnt1", "gene_names_refseq": "Pomgnt1", "protein_names_uniprotkb": "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; 2.4.1.-; POMGnT1", "protein_names_refseq": "O-linked mannose beta1,2-N-acetylglucosaminyltransferase; protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase; protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); retinitis pigmentosa 76 (Disease Ontology:DOID:0061103); autosomal recessive limb-girdle muscular dystrophy type 2O (Disease Ontology:DOID:0110292); congenital muscular dystrophy-dystroglycanopathy type A3 (Disease Ontology:DOID:0111236); muscular dystrophy-dystroglycanopathy type B3 (Disease Ontology:DOID:0112378); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:362567); (R-RNO-8932504); (R-RNO-8932506); (R-RNO-9939291)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans., [UniProtKB, UniProtKB]; Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.101", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.101", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0030246 carbohydrate binding;GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity;GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0009101 glycoprotein biosynthetic process;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0042552 myelination;GO:0007420 brain development", "synthesized_glycan_count": 198, "hit_score": 0.1, "record_id": "Q5XIN7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIP6-1", "uniprot_id": [ { "id": "FEN1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIP6", "type": "external" } ], "mass": 42609.0, "length": 380, "protein_name": "Flap endonuclease 1", "gene_name": "Fen1", "organism": "Rat", "refseq_name": "flap endonuclease 1", "refseq_ac": [ { "id": "NP_001401385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401385", "type": "external" } ], "gene_names_uniprotkb": "Fen1", "gene_names_refseq": "FEN-1; Fen1", "protein_names_uniprotkb": "Flap endonuclease 1; 3.1.-.-; FEN-1; Flap structure-specific endonuclease 1", "protein_names_refseq": "flap endonuclease 1", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:84490); (R-RNO-110362); (R-RNO-174437); (R-RNO-5651801); (R-RNO-5685939); (R-RNO-69166)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "19420241", "class_list": "", "function": "Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA., [UniProtKB, HAMAP]; This study defines the fen-1 endonuclease as a new DNA recombination/repair factor involved in the formation of long-term memories., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHW7", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0030145 manganese ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity;GO:0004527 exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006281 DNA repair;GO:0007613 memory;GO:0006284 base-excision repair;GO:0006260 DNA replication;GO:0043137 DNA replication, removal of RNA primer", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIP6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIX0-1", "uniprot_id": [ { "id": "DJC14_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIX0", "type": "external" } ], "mass": 79017.0, "length": 703, "protein_name": "DnaJ homolog subfamily C member 14", "gene_name": "Dnajc14", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 14", "refseq_ac": [ { "id": "NP_446142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446142", "type": "external" } ], "gene_names_uniprotkb": "Dnajc14; Drip78", "gene_names_refseq": "Dnajc14; Drip78", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 14; DRiP78; Dopamine receptor-interacting protein of 78 kDa", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 14; dnaJ homolog subfamily C member 14-like; dnaJ homolog subfamily C member 14; dopamine receptor interacting protein; dopamine receptor-interacting protein of 78 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:114481)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11331877", "class_list": "", "function": "Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q925G7", "ec_number_list": [], "go_molecular_function": "GO:0050780 dopamine receptor binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIX0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62633-1", "uniprot_id": [ { "id": "NTCP2_RAT", "url": "https://www.uniprot.org/uniprot/Q62633", "type": "external" } ], "mass": 38024.0, "length": 348, "protein_name": "Ileal sodium/bile acid cotransporter", "gene_name": "Slc10a2", "organism": "Rat", "refseq_name": "ileal sodium/bile acid cotransporter", "refseq_ac": [ { "id": "NP_058918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058918", "type": "external" } ], "gene_names_uniprotkb": "Slc10a2; Ntcp2", "gene_names_refseq": "ASBT; IBAT; ISBAT; ISBT; Slc10a2", "protein_names_uniprotkb": "Ileal sodium/bile acid cotransporter; ASBT; Apical sodium-dependent bile acid transporter; IBAT; ISBT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; Na(+)-dependent ileal bile acid transporter; Sodium/taurocholate-cotransporting polypeptide, ileal; Solute carrier family 10 member 2", "protein_names_refseq": "Na(+)-dependent ileal bile acid transporter; apical sodium-dependent bile acid transporter; ileal Na(+)/bile acid cotransporter; ileal sodium-dependent bile acid transporter; ileal sodium/bile acid cotransporter; sodium/taurocholate-cotransporting polypeptide, ileal; solute carrier family 10 (sodium/bile acid cotransporter family), member 2; solute carrier family 10 (sodium/bile acid cotransporter), member 2", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); intestinal disease (Disease Ontology:DOID:5295)", "pathway": " (rno:29500); (R-RNO-159418)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15133850;21526375;24498857;28299817;7860756", "class_list": "", "function": "Among the up-regulated hepatic genes that were identified, the expression of Olr59, Ethe1, and Slc10a2 increased specifically in rats neonatally exposed to triiodothyronine., [RefSeq, PubMed]; Data demonstrate that expression of ASBT and t-ASBT in cholangiocytes is regulated by a negative feedback loop while the expression of these transporters in terminal ileum is modified via positive feedback [ASBT], [RefSeq, PubMed]; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7860756). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate. Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity)., [UniProtKB, UniProtKB, PubMed]; The beneficial effect of rifampicin in cholestasis is associated with an increase in DME expression involved in toxic, bile acid and cholesterol metabolism, as well as a reduction in the bile acid importing system in hepatocytes., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008508 bile acid:sodium symporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0005902 microvillus;GO:0000502 proteasome complex", "go_biological_process": "GO:0015721 bile acid and bile salt transport;GO:0009617 response to bacterium;GO:0008206 bile acid metabolic process;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62633-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62755-1", "uniprot_id": [ { "id": "NR1H2_RAT", "url": "https://www.uniprot.org/uniprot/Q62755", "type": "external" } ], "mass": 49736.0, "length": 446, "protein_name": "Oxysterols receptor LXR-beta", "gene_name": "Nr1h2", "organism": "Rat", "refseq_name": "oxysterols receptor LXR-beta isoform b", "refseq_ac": [ { "id": "NP_113814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113814", "type": "external" } ], "gene_names_uniprotkb": "Nr1h2; Lxrb", "gene_names_refseq": "LXR beta; LXRB; LXRbeta; Nr1h2; OR-1", "protein_names_uniprotkb": "Oxysterols receptor LXR-beta; Liver X receptor beta; Nuclear receptor subfamily 1 group H member 2; Orphan nuclear receptor OR-1; UR; Ubiquitously-expressed nuclear receptor", "protein_names_refseq": "UR; liver X receptor beta; nuclear orphan receptor LXR-beta; orphan nuclear receptor OR-1; oxysterols receptor LXR-beta isoform b; oxysterols receptor LXR-beta; ubiquitous receptor; ubiquitously-expressed nuclear receptor", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:58851); (R-RNO-383280); (R-RNO-4090294); (R-RNO-8866427); (R-RNO-9029569); (R-RNO-9623433)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "29654801;30471864;31161476;7892230;7971966", "class_list": "", "function": "Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (By similarity). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results show that hippocampal LXRbeta levels were negatively correlated with the severity of the depressive-like behaviors. LXRbeta knockdown in hippocampus produced depression-like behaviors and impaired hippocampal neurogenesis, and conversely, the LXRbeta activation improved the depression-like behaviors and reversed the impaired hippocampal neurogenesis in rats., [RefSeq, PubMed]; The present work's main objective was to study the effect of different high fat diets on LXRs expression (in hypothalamus and liver), and lipid profile., [RefSeq, PubMed]; We observed increased expression of LXRalpha from an early stage of nephrosis. To explore the role of increased LXRalpha in diseased kidney in vitro, NRK52E, normal kidney tubular epithelial cells, were forced to overexpress LXRalpha. These cells showed significantly lower lipid accumulation than mock cells did. In contrast, LXRbeta knockdown led to increased lipid accumulation in mock cells, and constancy in overexpre..., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62694", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0034191 apolipoprotein A-I receptor binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0048550 negative regulation of pinocytosis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62755-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62833-1", "uniprot_id": [ { "id": "GRK5_RAT", "url": "https://www.uniprot.org/uniprot/Q62833", "type": "external" } ], "mass": 67783.0, "length": 590, "protein_name": "G protein-coupled receptor kinase 5", "gene_name": "Grk5", "organism": "Rat", "refseq_name": "G protein-coupled receptor kinase 5", "refseq_ac": [ { "id": "NP_110456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110456", "type": "external" } ], "gene_names_uniprotkb": "Grk5; Gprk5", "gene_names_refseq": "Gprk5; Grk5", "protein_names_uniprotkb": "G protein-coupled receptor kinase 5; 2.7.11.16; G protein-coupled receptor kinase GRK5", "protein_names_refseq": "G protein-coupled receptor kinase 5; g protein-coupled receptor kinase GRK5", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:59075); (R-RNO-418555)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11687284;11709416;12052842;12384166;12810562;27613164;29080472;29543709;37380112;8626574;8631993;9826657", "class_list": "", "function": "Acute and chronic morphine treatments and morphine withdrawal differentially regulate GRK2 and GRK5 gene expression in rat brain, [RefSeq, PubMed]; Expression of (K215R)GRK5 had no effect on beta-adrenergic signaling in myometrium., [RefSeq, PubMed]; Overexpression of GRK5-NT in cardiomyoblasts significantly reduced the activation and the nuclear translocation of NFAT and its cofactor GATA-4 in response to phenylephrine. Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that GRK5 may be involved in a UII-mediated hypertrophic response via activation of NF-kappaB and HDAC5 at least in part by ERK1/2 and GSK3alpha/beta-independent pathways., [RefSeq, PubMed]; Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor, LRP6 during Wnt signaling (in vitro) (By similarity)., [UniProtKB, PubMed]; TRPA1 deficiency attenuates cardiac fibrosis via regulating GRK5/NFAT signaling in diabetic rats., [RefSeq, PubMed]; This study showed that the GRK5 was involved in the development of epilepsy. It was associated with dendritic formation in epilepsy. Erratum:[Epilepsy Res. 2018 Jan;139:180. doi: 10.1016/j.eplepsyres.2017.12.007. PMID: 29273340], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008289 lipid binding;GO:0004703 G protein-coupled receptor kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck;GO:0031965 nuclear membrane;GO:0005634 nucleus", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0042220 response to cocaine;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q62833-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62867-1", "uniprot_id": [ { "id": "GGH_RAT", "url": "https://www.uniprot.org/uniprot/Q62867", "type": "external" } ], "mass": 35830.0, "length": 317, "protein_name": "Gamma-glutamyl hydrolase", "gene_name": "Ggh", "organism": "Rat", "refseq_name": "gamma-glutamyl hydrolase precursor", "refseq_ac": [ { "id": "NP_037092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037092", "type": "external" } ], "gene_names_uniprotkb": "Ggh", "gene_names_refseq": "Ggh", "protein_names_uniprotkb": "Gamma-glutamyl hydrolase; 3.4.19.9; Conjugase; GH; Gamma-Glu-X carboxypeptidase", "protein_names_refseq": "GH; conjugase; gamma-Glu-X carboxypeptidase; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); gamma-glutamyl hydrolase precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:25455); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "24090084;26432773;29393594;38843836;8343522;8621474", "class_list": "", "function": "Hepatic microRNA rno-miR-125b-3p is suppressed by quercetin-induced hepatic gamma-glutamyl hydrolase expression in rats, [RefSeq, PubMed]; Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates (PubMed:8343522, PubMed:8621474). Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Exhibits either endo- or exopeptidase activity depending upon the tissue of origin. When secreted, it acts primarily as an endopeptidase (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "1.4.3.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.22", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0034722 gamma-glutamyl-peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0042470 melanosome;GO:0005773 vacuole", "go_biological_process": "GO:0046900 tetrahydrofolylpolyglutamate metabolic process;GO:0010043 response to zinc ion;GO:0045471 response to ethanol;GO:0032868 response to insulin;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q62867-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62896-1", "uniprot_id": [ { "id": "BET1_RAT", "url": "https://www.uniprot.org/uniprot/Q62896", "type": "external" } ], "mass": 13230.0, "length": 118, "protein_name": "BET1 homolog", "gene_name": "Bet1", "organism": "Rat", "refseq_name": "BET1 homolog", "refseq_ac": [ { "id": "NP_062124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062124", "type": "external" } ], "gene_names_uniprotkb": "Bet1", "gene_names_refseq": "Bet1", "protein_names_uniprotkb": "BET1 homolog; Golgi vesicular membrane-trafficking protein p18; rBET1", "protein_names_refseq": "BET1 homolog; Golgi vesicular membrane-trafficking protein p18; golgi vesicular membrane trafficking protein p18; rBET1", "tax_id": 10116, "disease": "porencephaly (Disease Ontology:DOID:0060263); congenital muscular dystrophy with rapid progression (Disease Ontology:DOID:0061202); autosomal recessive brain small vessel disease 2B (Disease Ontology:DOID:0061233); autosomal dominant brain small vessel disease 2A (Disease Ontology:DOID:0112314); severe pre-eclampsia (Disease Ontology:DOID:13129); uterine fibroid (Disease Ontology:DOID:13223); atherosclerosis (Disease Ontology:DOID:1936); myopathy (Disease Ontology:DOID:423); collagen disease (Disease Ontology:DOID:854)", "pathway": " (rno:29631); (R-RNO-204005); (R-RNO-6807878)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10930465;12566453;14742712;22673903;8621431;9382863", "class_list": "", "function": "Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; SNARE motif contributes to rbet1 intracellular targeting and dynamics independently of SNARE interactions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005801 cis-Golgi network;GO:0031201 SNARE complex", "go_biological_process": "GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048280 vesicle fusion with Golgi apparatus;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62896-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62949-1", "uniprot_id": [ { "id": "CORT_RAT", "url": "https://www.uniprot.org/uniprot/Q62949", "type": "external" } ], "mass": 12201.0, "length": 112, "protein_name": "Cortistatin", "gene_name": "Cort", "organism": "Rat", "refseq_name": "cortistatin preproprotein", "refseq_ac": [ { "id": "NP_036967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036967", "type": "external" } ], "gene_names_uniprotkb": "Cort", "gene_names_refseq": "Cort", "protein_names_uniprotkb": "Cortistatin", "protein_names_refseq": "Preprocortistatin; cortistatin preproprotein", "tax_id": 10116, "disease": "Leber congenital amaurosis 7 (Disease Ontology:DOID:0110333); cone-rod dystrophy 2 (Disease Ontology:DOID:0111005); brain infarction (Disease Ontology:DOID:3454); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:25305)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11817718;17481746;23619555;27480534;28636167;29436118;8622767", "class_list": "", "function": "CST directly inhibited beta-GP-induced calcification of VSMCs in vitro, probably by suppressing ERS and phenotypic transformation of VSMCs into osteoblastic cells., [RefSeq, PubMed]; Inhibits aortic calcification and osteogenic differentiation of vascular smooth muscle cells likely via the GSK3beta/beta-catenin and PKC signalling pathways, but not JNK signalling pathway, [RefSeq, PubMed]; Neuropeptide with neuronal depressant and sleep-modulating properties (PubMed:11817718, PubMed:8622767). Acts as an inhibitor of growth hormone secretion (PubMed:11817718). Acts as a ligand for Mrgprb2 receptor in mast cells (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Oral berberine exerted anti-arthritic effect through inhibiting the Th17 cell response, which was closely associated with the induction of cortistatin generation from gut through augmenting autocrine/paracrine action between enteric nerve cells and endocrine cells., [RefSeq, PubMed]; Precursor of neuropeptides that bind to all somatostatin receptor (SSTR) subtypes (By similarity). Inhibits cAMP production induced by forskolin through SSTRs (By similarity)., [UniProtKB, UniProtKB]; RT-PCR and immunocytochemistry studies support the presence of cortistatin in rat Kupffer cells., [RefSeq, PubMed]; The DDAH/asymmetric dimethylarginine pathway participates in the pathogenesis of rheumatoid arthritis and may be mediated by cortistatin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62949-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62951-1", "uniprot_id": [ { "id": "DPYL4_RAT", "url": "https://www.uniprot.org/uniprot/Q62951", "type": "external" } ], "mass": 61086.0, "length": 564, "protein_name": "Dihydropyrimidinase-related protein 4", "gene_name": "Dpysl4", "organism": "Rat", "refseq_name": "dihydropyrimidinase-related protein 4", "refseq_ac": [ { "id": "NP_037065", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037065", "type": "external" } ], "gene_names_uniprotkb": "Dpysl4; Crmp3; Ulip4", "gene_names_refseq": "Crmp3; Dpys4; Dpysl4", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 4; CRMP-3; Collapsin response mediator protein 3; DRP-4; ULIP-4; UNC33-like phosphoprotein 4", "protein_names_refseq": "CRMP-3; Collapsin response mediator protein 3; DRP-4; ULIP-4; ULIP4 protein; UNC33-like phosphoprotein 4; dihydropyrimidinase-related protein 4", "tax_id": 10116, "disease": "cataract 39 multiple types (Disease Ontology:DOID:0110236)", "pathway": " (rno:25417); (R-RNO-399956)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18683930;19639589;8815901", "class_list": "", "function": "Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The findings demonstrated that calpain-truncated CRMP-3 and -4 act as pro-apoptotic players when CGNs undergo apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051219 phosphoprotein binding;GO:0031005 filamin binding;GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62951-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63016-1", "uniprot_id": [ { "id": "LAT1_RAT", "url": "https://www.uniprot.org/uniprot/Q63016", "type": "external" } ], "mass": 55903.0, "length": 512, "protein_name": "Large neutral amino acids transporter small subunit 1", "gene_name": "Slc7a5", "organism": "Rat", "refseq_name": "large neutral amino acids transporter small subunit 1", "refseq_ac": [ { "id": "NP_059049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059049", "type": "external" } ], "gene_names_uniprotkb": "Slc7a5; Lat1; Mpe16; Ta1", "gene_names_refseq": "E16; LAT-1; Slc7a5; TA1", "protein_names_uniprotkb": "Large neutral amino acids transporter small subunit 1; 4F2 LC; 4F2 light chain; 4F2LC; Integral membrane protein E16; L-type amino acid transporter 1; LAT-1; Protein TA1; Solute carrier family 7 member 5", "protein_names_refseq": "4F2 LC; 4F2 light chain; 4F2LC; L-type amino acid transporter 1; TA1/LAT-1/CD98 light chain region; integral membrane protein E16; large neutral amino acids transporter small subunit 1; solute carrier family 7 (amino acid transporter light chain, L system), member 5; solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; tumor-associated protein 1", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); large cell neuroendocrine carcinoma (Disease Ontology:DOID:0050872); autism spectrum disorder (Disease Ontology:DOID:0060041); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); lung pleomorphic carcinoma (Disease Ontology:DOID:0080899); stomach cancer (Disease Ontology:DOID:10534); esophageal carcinoma (Disease Ontology:DOID:1107); esophagitis (Disease Ontology:DOID:11963); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); gastric adenocarcinoma (Disease Ontology:DOID:3717); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); bile duct adenocarcinoma (Disease Ontology:DOID:4896); bile duct carcinoma (Disease Ontology:DOID:4897); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); malignant pleural mesothelioma (Disease Ontology:DOID:7474); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:50719); (R-RNO-210991); (R-RNO-352230); (R-RNO-71240)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "11095508;11311135;12614332;15120633;15980244;16027961;33540026;35048187;7532544;9726963", "class_list": "", "function": "Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain., [RefSeq, PubMed]; Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats., [RefSeq, PubMed]; The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, histidine, methionine, valine and alanine (By similarity). The heterodimer with SLC3A2 mediates the uptake of leucine, isoleucine and tryptophan (PubMed:11311135, PubMed:12614332, PubMed:15980244, PubMed:9726963). Functions as an amino acid exchanger (By similarity). May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (By similarity). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (Probable). Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane (By similarity). Mediates the uptake of 3-iodo-L-tyrosine (MIT) and 3,5-diiodo-L-tyrosine (DIT) (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWL4", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015196 L-tryptophan transmembrane transporter activity;GO:0042605 peptide antigen binding;GO:0015171 amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:0032740 positive regulation of interleukin-17 production;GO:0015820 L-leucine transport;GO:0015824 proline transport;GO:0032328 alanine transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q63016-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63054-1", "uniprot_id": [ { "id": "ICA69_RAT", "url": "https://www.uniprot.org/uniprot/Q63054", "type": "external" } ], "mass": 54663.0, "length": 480, "protein_name": "Islet cell autoantigen 1", "gene_name": "Ica1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ica1", "gene_names_refseq": "", "protein_names_uniprotkb": "Islet cell autoantigen 1; 69 kDa islet cell autoantigen; ICA69; ICAp69; Islet cell autoantigen p69; p69", "protein_names_refseq": "", "tax_id": 10116, "disease": "diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7918678", "class_list": "", "function": "May play a role in neurotransmitter secretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P3W0", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0140090 membrane curvature sensor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0097753 membrane bending;GO:0043254 regulation of protein-containing complex assembly;GO:0051046 regulation of secretion;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63054-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63111-1", "uniprot_id": [ { "id": "CEAM3_RAT", "url": "https://www.uniprot.org/uniprot/Q63111", "type": "external" } ], "mass": 78311.0, "length": 709, "protein_name": "Cell adhesion molecule CEACAM3", "gene_name": "Ceacam3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ceacam3; Cea1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cell adhesion molecule CEACAM3; CEA cell adhesion molecule 3; Carcinoembryonic antigen CGM1; Carcinoembryonic antigen-related cell adhesion molecule 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2335509;2708349", "class_list": "", "function": "Possibly involved in cell adhesion., [UniProtKB, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 16, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q63101", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63111-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63245-1", "uniprot_id": [ { "id": "FOXD3_RAT", "url": "https://www.uniprot.org/uniprot/Q63245", "type": "external" } ], "mass": 11943.0, "length": 101, "protein_name": "Forkhead box protein D3", "gene_name": "Foxd3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Foxd3; Hfh2", "gene_names_refseq": "", "protein_names_uniprotkb": "Forkhead box protein D3; HFH-2; HNF3/FH transcription factor genesis; Hepatocyte nuclear factor 3 forkhead homolog 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "vitiligo (Disease Ontology:DOID:12306); glaucoma (Disease Ontology:DOID:1686)", "pathway": " (rno:29203)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "40272767;7683413;9571051", "class_list": "", "function": "Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator (By similarity). Negatively regulates transcription of transcriptional repressor Rhit/Zfp13 (By similarity). Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63245-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63246-1", "uniprot_id": [ { "id": "FOXC2_RAT", "url": "https://www.uniprot.org/uniprot/Q63246", "type": "external" } ], "mass": 52854.0, "length": 494, "protein_name": "Forkhead box protein C2", "gene_name": "Foxc2", "organism": "Rat", "refseq_name": "forkhead box protein C2", "refseq_ac": [ { "id": "NP_001095150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095150", "type": "external" } ], "gene_names_uniprotkb": "Foxc2; Hfhbf3", "gene_names_refseq": "Fkh14; Fkhl14; Foxc2; Hfhbf3", "protein_names_uniprotkb": "Forkhead box protein C2; BF-3; Brain factor 3; HFH-BF-3", "protein_names_refseq": "BF-3; HFH-BF-3; brain factor 3; forkhead box C2 (MFH-1, mesenchyme forkhead 1); forkhead box protein C2", "tax_id": 10116, "disease": "ptosis (Disease Ontology:DOID:0060260); lymphedema-distichiasis syndrome (Disease Ontology:DOID:0111509); nephritis (Disease Ontology:DOID:10952); lymphedema (Disease Ontology:DOID:4977); eyelid disease (Disease Ontology:DOID:530); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:171356)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22673903;26824865;33423166;34739190;7683413", "class_list": "", "function": "Adenovirus-mediated FoxC2 expression enhances BMP7-facilitated anabolism in nucleus pulposus cells of the intervertebral discs. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-26a regulated adipogenic differentiation of ADSCs induced by insulin through CDK5/FOXC2 pathway. Erratum:[Mol Cell Biochem. 2021 Aug;476(8):3217. doi: 10.1007/s11010-021-04212-3. PMID: 34156588], [RefSeq, PubMed]; Micro ribonucleic acid-363 regulates the phosphatidylinositol 3-kinase/threonine protein kinase axis by targeting NOTCH1 and forkhead box C2, leading to hepatic glucose and lipids metabolism disorder in type 2 diabetes mellitus., [RefSeq, PubMed]; Transcriptional activator., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "M0R736", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0048341 paraxial mesoderm formation;GO:0035470 positive regulation of vascular wound healing;GO:0048343 paraxial mesodermal cell fate commitment;GO:1902257 negative regulation of apoptotic process involved in outflow tract morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63246-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63248-1", "uniprot_id": [ { "id": "FOXI2_RAT", "url": "https://www.uniprot.org/uniprot/Q63248", "type": "external" } ], "mass": 11988.0, "length": 101, "protein_name": "Forkhead box protein I2", "gene_name": "Foxi2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Foxi2; Foxi1; Hfh5", "gene_names_refseq": "", "protein_names_uniprotkb": "Forkhead box protein I2; HFH-5; Hepatocyte nuclear factor 3 forkhead homolog 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7683413", "class_list": "", "function": "Possible transcriptional activator., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63248-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63249-1", "uniprot_id": [ { "id": "FOXD4_RAT", "url": "https://www.uniprot.org/uniprot/Q63249", "type": "external" } ], "mass": 11799.0, "length": 101, "protein_name": "Forkhead box protein D4", "gene_name": "Foxd4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Foxd4; Fkhl9; Freac5; Hfh6", "gene_names_refseq": "", "protein_names_uniprotkb": "Forkhead box protein D4; FREAC-5; Forkhead-related protein FKHL9; Forkhead-related transcription factor 5; HFH-6; Hepatocyte nuclear factor 3 forkhead homolog 6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7683413", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63249-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63273-1", "uniprot_id": [ { "id": "GRIK5_RAT", "url": "https://www.uniprot.org/uniprot/Q63273", "type": "external" } ], "mass": 109276.0, "length": 979, "protein_name": "Glutamate receptor ionotropic, kainate 5", "gene_name": "Grik5", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, kainate 5 precursor", "refseq_ac": [ { "id": "NP_113696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113696", "type": "external" } ], "gene_names_uniprotkb": "Grik5", "gene_names_refseq": "GluK5; Grik5; iGlu5", "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 5; GluK5; Glutamate receptor KA-2; KA2", "protein_names_refseq": "glutamate receptor KA-2; glutamate receptor KA2; glutamate receptor ionotropic, kainate 5 precursor; glutamate receptor, ionotropic, kainate 5", "tax_id": 10116, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (rno:24407); (R-RNO-451308)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "12954862;1373632;20951142;21791290;22509486;23288040;23975096;25139762;38843836;9254673;9390526", "class_list": "", "function": "CaMKII-dependent phosphorylation of GluK5 is responsible for synaptic depression by untrapping of KARs from the PSD and increased diffusion away from synaptic sites., [RefSeq, PubMed]; Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and produces channel activity only in heteromeric assembly with GRIK1, GRIK2 and GRIK3 subunits., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB]; These findings indicate that ligand binding to only the GluK5 subunit is both necessary and sufficient to allow trafficking of recombinant GluK2/K5 heteromers to the cell membrane, but that occupancy of the GluK2 site alone is not., [RefSeq, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 6, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 6, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 6, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q62643", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0030165 PDZ domain binding;GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0060079 excitatory postsynaptic potential;GO:0071333 cellular response to glucose stimulus;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q63273-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63340-1", "uniprot_id": [ { "id": "DUS7_RAT", "url": "https://www.uniprot.org/uniprot/Q63340", "type": "external" } ], "mass": 45067.0, "length": 419, "protein_name": "Dual specificity protein phosphatase 7", "gene_name": "Dusp7", "organism": "Rat", "refseq_name": "dual specificity protein phosphatase 7", "refseq_ac": [ { "id": "NP_001094017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094017", "type": "external" } ], "gene_names_uniprotkb": "Dusp7; Mkpx", "gene_names_refseq": "Dusp7; mkp-X", "protein_names_uniprotkb": "Dual specificity protein phosphatase 7; 3.1.3.16; 3.1.3.48; Dual specificity protein phosphatase MKP-X", "protein_names_refseq": "MAP kinase phosphatase; dual specificity protein phosphatase 7; dual specificity protein phosphatase MKP-X", "tax_id": 10116, "disease": "", "pathway": " (rno:300980); (R-RNO-112409); (R-RNO-202670); (R-RNO-5675221)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "26435497;27783954;8626780", "class_list": "", "function": "Dual specificity protein phosphatase (By similarity). Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex., [UniProtKB, UniProtKB, UniProtKB]; The expression of DUSP6 and DUSP7 is mediated by ERK1/ERK2 activity in microglia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1M7V9", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0033550 MAP kinase tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0043407 negative regulation of MAP kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63340-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63345-1", "uniprot_id": [ { "id": "MOG_RAT", "url": "https://www.uniprot.org/uniprot/Q63345", "type": "external" } ], "mass": 27882.0, "length": 245, "protein_name": "Myelin-oligodendrocyte glycoprotein", "gene_name": "Mog", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mog", "gene_names_refseq": "", "protein_names_uniprotkb": "Myelin-oligodendrocyte glycoprotein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 9, "publication_id_list": "1453482;19487416;24090084;7525700;7684687;8367453;8557821;9083925;9210466", "class_list": "", "function": "Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 20, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 74, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0050852 T cell receptor signaling pathway;GO:0033993 response to lipid;GO:0001817 regulation of cytokine production;GO:0051593 response to folic acid", "synthesized_glycan_count": 0, "hit_score": 8.5, "record_id": "Q63345-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63371-1", "uniprot_id": [ { "id": "P2RY6_RAT", "url": "https://www.uniprot.org/uniprot/Q63371", "type": "external" } ], "mass": 36677.0, "length": 328, "protein_name": "P2Y purinoceptor 6", "gene_name": "P2ry6", "organism": "Rat", "refseq_name": "P2Y purinoceptor 6", "refseq_ac": [ { "id": "NP_476465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476465", "type": "external" } ], "gene_names_uniprotkb": "P2ry6", "gene_names_refseq": "P2ry6; P2y6", "protein_names_uniprotkb": "P2Y purinoceptor 6; P2Y6", "protein_names_refseq": "P2Y ATP receptor 6; P2Y purinoceptor 6; pyrimidinergic receptor P2Y, G-protein coupled, 6", "tax_id": 10116, "disease": "", "pathway": " (rno:117264); (R-RNO-416476); (R-RNO-417957)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "11934835;25449358;31106899;31638262;35349212;7592819", "class_list": "", "function": "In conclusion, the changes in the expression of lncRNAs, mRNAs and proteins (Adamts7, P2ry6, Dlx3 and TP53) may possibly affect endometrial receptivity in rats with endometriosis during the implantation window, probably resulting in implantation failure of the embryo., [RefSeq, PubMed]; Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress., [RefSeq, PubMed]; Prominent role for the UDP receptor, P2Y(6), in UTP-induced rat ASMC migration, [RefSeq, PubMed]; Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C., [UniProtKB]; Results suggest that peripheral activation of P2Y1, P2Y6 and P2Y11 receptors plays a pronociceptive role in formalin-induced pain., [RefSeq, PubMed]; The role of P2Y6 receptors in the maintenance of neuropathic pain and its improvement of oxidative stress in rats., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001621 G protein-coupled ADP receptor activity;GO:0045029 G protein-coupled UDP receptor activity;GO:0045030 G protein-coupled UTP receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0006909 phagocytosis;GO:0071380 cellular response to prostaglandin E stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63371-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63410-1", "uniprot_id": [ { "id": "OTX1_RAT", "url": "https://www.uniprot.org/uniprot/Q63410", "type": "external" } ], "mass": 37603.0, "length": 355, "protein_name": "Homeobox protein OTX1", "gene_name": "Otx1", "organism": "Rat", "refseq_name": "homeobox protein OTX1", "refseq_ac": [ { "id": "NP_037241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037241", "type": "external" } ], "gene_names_uniprotkb": "Otx1", "gene_names_refseq": "OTX1X; Otx1", "protein_names_uniprotkb": "Homeobox protein OTX1; Orthodenticle homolog 1", "protein_names_refseq": "homeobox protein OTX1-like; homeobox protein OTX1", "tax_id": 10116, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:25646)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11906214;38635011;7931541;8613727", "class_list": "", "function": "MiR-497-5p ameliorates the oxyhemoglobin-induced subarachnoid hemorrhage injury in vitro by targeting orthodenticle homeobox protein 1 (Otx1) to activate the Nrf2/HO-1 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3' (By similarity). May play a role in the specification or differentiation of neurons in the deep layers of the cerebral cortex, and also in cerebellar regionalization during early development., [UniProtKB]; Ventricular cells actively sequester Otx1 in the cytoplasm, either by preventing nuclear import or by promoting a balance of export over import signals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64203", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048852 diencephalon morphogenesis;GO:0022037 metencephalon development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q63410-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63634-1", "uniprot_id": [ { "id": "NPY5R_RAT", "url": "https://www.uniprot.org/uniprot/Q63634", "type": "external" } ], "mass": 50408.0, "length": 445, "protein_name": "Neuropeptide Y receptor type 5", "gene_name": "Npy5r", "organism": "Rat", "refseq_name": "neuropeptide Y receptor type 5", "refseq_ac": [ { "id": "NP_037001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037001", "type": "external" } ], "gene_names_uniprotkb": "Npy5r; Npyr5", "gene_names_refseq": "NPYR5; Npy5r", "protein_names_uniprotkb": "Neuropeptide Y receptor type 5; NPY-Y5 receptor; NPY5-R; NPYY5-R; Y5 receptor", "protein_names_refseq": "NPY-Y5 receptor; NPY5-R; NPYY5-R; Neuropeptide Y5 receptor; Y5 receptor; neuropeptide Y receptor type 5", "tax_id": 10116, "disease": "peripheral artery disease (Disease Ontology:DOID:0050830); absence epilepsy (Disease Ontology:DOID:0070309); alcohol use disorder (Disease Ontology:DOID:1574); hyperinsulinism (Disease Ontology:DOID:2018); lipid metabolism disorder (Disease Ontology:DOID:3146); coronary restenosis (Disease Ontology:DOID:4247); prolactinoma (Disease Ontology:DOID:5394); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:25340); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "24444822;25993471;28057538;8700207;8824284;9669502", "class_list": "", "function": "Long-term over-expression of NPY in paraventricular nucleus contributes to the establishment of adipose tissue insulin resistance, at least partly via the Y5 receptor Publication Status: Online-Only, [RefSeq, PubMed]; NPY and agonists of Y2R and Y5R may be neuroprotective against oxygen-glucose deprivation-induced neuronal cell death in primary cortical cell cultures after delayed treatment. A Y2R agonist not only diminished transient cerebral ischemia-induced neuronal injury, but also improved functional outcome after delayed treatment. Y5 and especially Y2 receptors may be promising targets for neuroprotection against ischemic damage, [RefSeq, PubMed]; Our results showed the altered expression of NPY, Y1R and Y2R but not Y5R in hippocampus and temporal lobe cortex of tremor rat brain., [RefSeq, PubMed]; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P70586", "ec_number_list": [], "go_molecular_function": "GO:0004983 neuropeptide Y receptor activity;GO:0001601 peptide YY receptor activity;GO:0001602 pancreatic polypeptide receptor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043005 neuron projection;GO:0098793 presynapse", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0045471 response to ethanol;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q63634-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63704-1", "uniprot_id": [ { "id": "CPT1B_RAT", "url": "https://www.uniprot.org/uniprot/Q63704", "type": "external" } ], "mass": 88217.0, "length": 772, "protein_name": "Carnitine O-palmitoyltransferase 1, muscle isoform", "gene_name": "Cpt1b", "organism": "Rat", "refseq_name": "carnitine O-palmitoyltransferase 1, muscle isoform", "refseq_ac": [ { "id": "NP_037332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037332", "type": "external" } ], "gene_names_uniprotkb": "Cpt1b", "gene_names_refseq": "CPT-IB; Cpt1b; M-CPTI", "protein_names_uniprotkb": "Carnitine O-palmitoyltransferase 1, muscle isoform; 2.3.1.21; CPT I; CPT1-M; CPTI-M; Carnitine O-palmitoyltransferase I, muscle isoform; Carnitine palmitoyltransferase 1B; Carnitine palmitoyltransferase I-like protein", "protein_names_refseq": "CPT I; CPT-Ibeta 1; CPT-Ibeta 3; CPT1-M; CPTI-M; Carnitine palmitoyltransferase 1, muscle; carnitine O-palmitoyltransferase 1, muscle isoform; carnitine palmitoyltransferase 1b, muscle; carnitine palmitoyltransferase I-like protein; carnitine palmitoyltransferase Ibeta 1; carnitine palmitoyltransferase Ibeta 2; carnitine palmitoyltransferase Ibeta 3", "tax_id": 10116, "disease": "cataract 17 multiple types (Disease Ontology:DOID:0110270); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:25756); (R-RNO-200425)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11879187;22928974;24222496;25855307;26080315;27213235;27558315;34502162;7729550;8636126", "class_list": "", "function": "A novel region in the first exon/intron of the CPT-Ibeta gene acts as a non-classical transcriptional enhancer, [RefSeq, PubMed]; CPT1B was significantly over-expressed in the amygdala and in the blood of stressed rats compared with non-stressed controls. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion., [UniProtKB, PubMed, PubMed]; In summary, our results show that oxfenicine-induced inhibition of CPT-1b markedly affects WAT metabolism, leading to reduced adiposity through a mechanism that involves reduced lipogenesis in the SC Ing and Epid fat depots of rats., [RefSeq, PubMed]; Increased fat accumulation characterizing obesity may be caused by impaired oxidative capacity due to decreased carnitine palmitoyltransferase 1b levels in the white adipose tissue., [RefSeq, PubMed]; The ratio of [P-CoA]/[M-CoA] is critical for regulating CPT-I activity & may partially rectify the in vivo disconnect between M-CoA content & CPT-I flux within the context of exercise & Type 2 diabetes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0004095 carnitine O-palmitoyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006853 carnitine shuttle;GO:0015909 long-chain fatty acid transport;GO:0009437 carnitine metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q63704-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63788-1", "uniprot_id": [ { "id": "P85B_RAT", "url": "https://www.uniprot.org/uniprot/Q63788", "type": "external" } ], "mass": 81329.0, "length": 722, "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "Pik3r2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pik3r2", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase regulatory subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; PtdIns-3-kinase regulatory subunit p85-beta", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); colon cancer (Disease Ontology:DOID:219); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (R-RNO-109704); (R-RNO-112399); (R-RNO-114604); (R-RNO-1257604); (R-RNO-1266695); (R-RNO-1433557); (R-RNO-1660499); (R-RNO-186763); (R-RNO-198203); (R-RNO-201556); (R-RNO-202424); (R-RNO-2029485); (R-RNO-210993); (R-RNO-2424491); (R-RNO-2730905); (R-RNO-389357); (R-RNO-416476); (R-RNO-4420097); (R-RNO-512988); (R-RNO-5673001); (R-RNO-6811558); (R-RNO-8853659); (R-RNO-8980692); (R-RNO-9009391); (R-RNO-9013026); (R-RNO-9013148); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013409); (R-RNO-9013420); (R-RNO-9013423); (R-RNO-9035034); (R-RNO-912526); (R-RNO-912631); (R-RNO-9696264); (R-RNO-9696270); (R-RNO-9696273); (R-RNO-9842663); (R-RNO-9927354)", "pathway_count": 39, "publication_count": 1, "publication_id_list": "8621382", "class_list": "", "function": "Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. Promotes nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005096 GTPase activator activity;GO:0046982 protein heterodimerization activity;GO:0030971 receptor tyrosine kinase binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0005943 phosphatidylinositol 3-kinase complex, class IA", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0010506 regulation of autophagy;GO:0015031 protein transport;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63788-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64119-2", "uniprot_id": [ { "id": "MYL6_RAT", "url": "https://www.uniprot.org/uniprot/Q64119", "type": "external" } ], "mass": 16975.0, "length": 151, "protein_name": "Myosin light polypeptide 6", "gene_name": "Myl6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myl6", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin light polypeptide 6; 17 kDa myosin light chain; LC17; MLC-3; Myosin light chain 3; Myosin light chain A3; Myosin light chain alkali 3; Smooth muscle and nonmuscle myosin light chain alkali 6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7733921", "class_list": "", "function": "Regulatory light chain of myosin. Does not bind calcium., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0003774 cytoskeletal motor activity;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005903 brush border;GO:0016459 myosin complex;GO:0016461 unconventional myosin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0030049 muscle filament sliding;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64119-2", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Y0-1", "uniprot_id": [ { "id": "OST48_RAT", "url": "https://www.uniprot.org/uniprot/Q641Y0", "type": "external" } ], "mass": 48896.0, "length": 441, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "gene_name": "Ddost", "organism": "Rat", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor", "refseq_ac": [ { "id": "NP_001012104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012104", "type": "external" } ], "gene_names_uniprotkb": "Ddost", "gene_names_refseq": "Ddost", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; DDOST 48 kDa subunit; Oligosaccharyl transferase 48 kDa subunit", "protein_names_refseq": "DDOST 48 kDa subunit; dolichyl-di-phosphooligosaccharide-protein glycotransferase; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic); dolichyl-diphosphooligosaccharide-protein glycosyltransferase; oligosaccharyl transferase 48 kDa subunit", "tax_id": 10116, "disease": "congenital disorder of glycosylation Ir (Disease Ontology:DOID:0080569)", "pathway": " (rno:313648); (R-RNO-6798695); (R-RNO-9768727); (R-RNO-9931295)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "26824730;38843836", "class_list": "", "function": "Data suggest expression of Rage (advanced glycosylation end product-specific receptor) and Ager1/Ddost can be altered by dietary factors; diet high in AGE (advanced glycation end products) up-regulates expression of Rage and Ager1/Ddost after 2 weeks., [RefSeq, PubMed]; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0042110 T cell activation;GO:0031647 regulation of protein stability;GO:0034097 response to cytokine;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q641Y0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Y9-1", "uniprot_id": [ { "id": "DALD3_RAT", "url": "https://www.uniprot.org/uniprot/Q641Y9", "type": "external" } ], "mass": 59045.0, "length": 538, "protein_name": "DALR anticodon-binding domain-containing protein 3", "gene_name": "Dalrd3", "organism": "Rat", "refseq_name": "DALR anticodon-binding domain-containing protein 3", "refseq_ac": [ { "id": "NP_001014236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014236", "type": "external" } ], "gene_names_uniprotkb": "Dalrd3", "gene_names_refseq": "Dalrd3", "protein_names_uniprotkb": "DALR anticodon-binding domain-containing protein 3", "protein_names_refseq": "DALR anticodon-binding domain-containing protein 3", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 86 (Disease Ontology:DOID:0112220)", "pathway": " (rno:363146)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Involved in tRNA methylation. Facilitates the recognition and targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-methylcytidine modification by METTL2., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004814 arginine-tRNA ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0006420 arginyl-tRNA aminoacylation;GO:0106217 tRNA C3-cytosine methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q641Y9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Z4-1", "uniprot_id": [ { "id": "CDK9_RAT", "url": "https://www.uniprot.org/uniprot/Q641Z4", "type": "external" } ], "mass": 42762.0, "length": 372, "protein_name": "Cyclin-dependent kinase 9", "gene_name": "Cdk9", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 9", "refseq_ac": [ { "id": "NP_001007744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007744", "type": "external" } ], "gene_names_uniprotkb": "Cdk9", "gene_names_refseq": "Cdk9", "protein_names_uniprotkb": "Cyclin-dependent kinase 9; 2.7.11.22; 2.7.11.23; Cell division protein kinase 9", "protein_names_refseq": "cell division protein kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); cyclin-dependent kinase 9", "tax_id": 10116, "disease": "renal carcinoma (Disease Ontology:DOID:4451); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:362110); (R-RNO-112382); (R-RNO-2173796); (R-RNO-674695); (R-RNO-6796648); (R-RNO-6807505); (R-RNO-75955); (R-RNO-9018519)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "32341082;38167752", "class_list": "", "function": "Differential Activation of P-TEFb Complexes in the Development of Cardiomyocyte Hypertrophy following Activation of Distinct G Protein-Coupled Receptors. Publication Status: Online-Only, [RefSeq, PubMed]; Long noncoding RNA small nucleolar RNA host gene 5 facilitates neuropathic pain in spinal nerve injury by promoting SCN9A expression via CDK9., [RefSeq, PubMed]; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. Also catalyzes phosphorylation of histone H1.4 (H1-4) at Ser-187' (H1.4S187Ph), a modification associated with transcription activation. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation. Catalyzes phosphorylation of KAT5, promoting KAT5 recruitment to chromatin and histone acetyltransferase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0008023 transcription elongation factor complex;GO:0016605 PML body;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006468 protein phosphorylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0071345 cellular response to cytokine stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q641Z4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q642A4-1", "uniprot_id": [ { "id": "CH082_RAT", "url": "https://www.uniprot.org/uniprot/Q642A4", "type": "external" } ], "mass": 24397.0, "length": 218, "protein_name": "UPF0598 protein C8orf82 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "UPF0598 protein C8orf82 homolog", "refseq_ac": [ { "id": "NP_001007752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007752", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "C7h8orf82", "protein_names_uniprotkb": "UPF0598 protein C8orf82 homolog", "protein_names_refseq": "UPF0598 protein C8orf82 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:362946)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q642A4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64559-2", "uniprot_id": [ { "id": "BACH_RAT", "url": "https://www.uniprot.org/uniprot/Q64559", "type": "external" } ], "mass": 42735.0, "length": 381, "protein_name": "Cytosolic acyl coenzyme A thioester hydrolase", "gene_name": "Acot7", "organism": "Rat", "refseq_name": "cytosolic acyl coenzyme A thioester hydrolase isoform 1", "refseq_ac": [ { "id": "NP_001139533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139533", "type": "external" } ], "gene_names_uniprotkb": "Acot7; Bach", "gene_names_refseq": "ACH1; ACT; Acot7; Bach; CTE-IIa; CTE-IIb; CTE-II; LACH1; MTE-II", "protein_names_uniprotkb": "Cytosolic acyl coenzyme A thioester hydrolase; 3.1.2.2; ACH1; ACT; Acyl-CoA thioesterase 7; BACH; Brain acyl-CoA hydrolase; CTE-IIa; CTE-IIb; CTE-II; LACH1; Long chain acyl-CoA thioester hydrolase; MTE-II", "protein_names_refseq": "brain acyl-CoA hydrolase; cytosolic acyl coenzyme A thioester hydrolase isoform 1; cytosolic acyl coenzyme A thioester hydrolase; long chain acyl-CoA thioester hydrolase", "tax_id": 10116, "disease": "", "pathway": " (rno:26759); (R-RNO-77289)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11755680;18683930;22673903;7906114;8631842;9125130;9163348", "class_list": "", "function": "Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:7906114). Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:7906114). May play an important physiological function in brain (PubMed:7906114)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08652;O09041", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0052689 carboxylic ester hydrolase activity;GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0043005 neuron projection;GO:0044297 cell body", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0009062 fatty acid catabolic process;GO:0015937 coenzyme A biosynthetic process;GO:0036114 medium-chain fatty-acyl-CoA catabolic process;GO:0036116 long-chain fatty-acyl-CoA catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64559-2", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64623-1", "uniprot_id": [ { "id": "DUS1_RAT", "url": "https://www.uniprot.org/uniprot/Q64623", "type": "external" } ], "mass": 39541.0, "length": 367, "protein_name": "Dual specificity protein phosphatase 1", "gene_name": "Dusp1; ENSRNOG00000069024", "organism": "Rat", "refseq_name": "dual specificity protein phosphatase 1", "refseq_ac": [ { "id": "NP_446221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446221", "type": "external" } ], "gene_names_uniprotkb": "Dusp1; ENSRNOG00000069024; Cl100; Dusp1; Mkp1; Ptpn16", "gene_names_refseq": "3CH134; CL100; Dusp1; MKP-1; Mkp1; Ptpn16", "protein_names_uniprotkb": "Dual specificity protein phosphatase 1; 3.1.3.16; 3.1.3.48; MAP kinase phosphatase 1; MKP-1; Mitogen-activated protein kinase phosphatase 1; Protein-tyrosine phosphatase CL100; Protein-tyrosine phosphatase non-receptor type 16", "protein_names_refseq": "3CH134/CL100 PTPase; MAP kinase phosphatase-1; dual specificity protein phosphatase 1; mitogen-activated protein (MAP) kinase phosphatase-1; mitogen-activated protein kinase phosphatase 1; oxidative stress-inducible protein tyrosine phosphatase; protein-tyrosine phosphatase CL100; protein-tyrosine phosphatase non-receptor type 16", "tax_id": 10116, "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); prostate cancer (Disease Ontology:DOID:10283); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); Huntington's disease (Disease Ontology:DOID:12858); major depressive disorder (Disease Ontology:DOID:1470); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian carcinoma (Disease Ontology:DOID:4001); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pancreatitis (Disease Ontology:DOID:4989); psoriasis (Disease Ontology:DOID:8893); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:114856); (R-RNO-112409); (R-RNO-5675221)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11423551;15527789;19103603;36336032;37340011;37776398;38424085;38499157;8106404", "class_list": "", "function": "DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with M feminine Teresa along the purinergic pathways of Eden., [RefSeq, PubMed]; Differential expression of Dusp1 and immediate early response genes in the hippocampus of rats, subjected to forced swim test. Publication Status: Online-Only, [RefSeq, PubMed]; Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle., [UniProtKB, UniProtKB]; MKP1 may be involved in the occurrence of depression by regulating hippocampal autophagy in rats., [RefSeq, PubMed]; RGD1564534 represses NLRP3 inflammasome activity in cerebral injury following ischemia-reperfusion by impairing miR-101a-3p-mediated Dusp1 inhibition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q548G6", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0019838 growth factor binding;GO:0051019 mitogen-activated protein kinase binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:1990869 cellular response to chemokine;GO:0090027 negative regulation of monocyte chemotaxis;GO:0007162 negative regulation of cell adhesion;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q64623-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64680-1", "uniprot_id": [ { "id": "CP2D4_RAT", "url": "https://www.uniprot.org/uniprot/Q64680", "type": "external" } ], "mass": 56684.0, "length": 500, "protein_name": "Cytochrome P450 2D4", "gene_name": "Cyp2d4", "organism": "Rat", "refseq_name": "cytochrome P450 2D4", "refseq_ac": [ { "id": "NP_612524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612524", "type": "external" } ], "gene_names_uniprotkb": "Cyp2d4; Cyp2d-18; Cyp2d-4; Cyp2d18", "gene_names_refseq": "Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2; Cyp2d4; Cyp2d6", "protein_names_uniprotkb": "Cytochrome P450 2D4; 1.14.14.1; CYPIID18; CYPIID4; Cytochrome P450 2D-29; Cytochrome P450 2D-35; Cytochrome P450 2D18; Cytochrome P450-CMF3; Cytochrome P450-DB4; Debrisoquine 4-hydroxylase", "protein_names_refseq": "CYPIID18; CYPIID4; Cytochrome P450, subfamily IID4; P450 2D-29/2D-35; P450-CMF3; P450-DB4; cytochrome P450 2D-29; cytochrome P450 2D-35; cytochrome P450 2D4; cytochrome P450 2d18; cytochrome P450, family 2, subfamily d, polypeptide 22; cytochrome P450, subfamily 2D, polypeptide 6; cytochrome P450, subfamily IID, polypeptide 6; cytochrome P450-CMF3; cytochrome P450-DB4; debrisoquine 4-hydroxylase", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); traumatic brain injury (Disease Ontology:DOID:0081292); extrapyramidal and movement disease (Disease Ontology:DOID:13839); major depressive disorder (Disease Ontology:DOID:1470); autoimmune hepatitis (Disease Ontology:DOID:2048); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); acute myeloid leukemia (Disease Ontology:DOID:9119); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:171522); (R-RNO-211935); (R-RNO-211958); (R-RNO-211981); (R-RNO-211999); (R-RNO-9027307); (R-RNO-9749641)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "2107330;29393594;3190674;34096834;39063146;7733922;8578766;9434752", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]; Metabolic activation of zolmitriptan mediated by CYP2D6., [RefSeq, PubMed]; The Effect of Maternal High-Fat or High-Carbohydrate Diet during Pregnancy and Lactation on Cytochrome P450 2D (CYP2D) in the Liver and Brain of Rat Offspring. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35107;P13108;Q566D3", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0016098 monoterpenoid metabolic process;GO:0042572 retinol metabolic process;GO:0006805 xenobiotic metabolic process;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q64680-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H63-1", "uniprot_id": [ { "id": "GDAP2_RAT", "url": "https://www.uniprot.org/uniprot/Q66H63", "type": "external" } ], "mass": 56130.0, "length": 497, "protein_name": "Ganglioside-induced differentiation-associated-protein 2", "gene_name": "Gdap2", "organism": "Rat", "refseq_name": "ganglioside-induced differentiation-associated-protein 2", "refseq_ac": [ { "id": "NP_001013219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013219", "type": "external" } ], "gene_names_uniprotkb": "Gdap2", "gene_names_refseq": "Gdap2", "protein_names_uniprotkb": "Ganglioside-induced differentiation-associated-protein 2", "protein_names_refseq": "ganglioside-induced differentiation-associated-protein 2", "tax_id": 10116, "disease": "autosomal recessive spinocerebellar ataxia 27 (Disease Ontology:DOID:0111616)", "pathway": " (rno:362004)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0032526 response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H63-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H86-1", "uniprot_id": [ { "id": "OLFL1_RAT", "url": "https://www.uniprot.org/uniprot/Q66H86", "type": "external" } ], "mass": 45600.0, "length": 402, "protein_name": "Olfactomedin-like protein 1", "gene_name": "Olfml1", "organism": "Rat", "refseq_name": "olfactomedin-like protein 1 precursor", "refseq_ac": [ { "id": "NP_001013210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013210", "type": "external" } ], "gene_names_uniprotkb": "Olfml1", "gene_names_refseq": "Olfml1", "protein_names_uniprotkb": "Olfactomedin-like protein 1", "protein_names_refseq": "olfactomedin-like protein 1 precursor; olfactomedin-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361621)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H86-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H89-1", "uniprot_id": [ { "id": "CEP83_RAT", "url": "https://www.uniprot.org/uniprot/Q66H89", "type": "external" } ], "mass": 81909.0, "length": 692, "protein_name": "Centrosomal protein of 83 kDa", "gene_name": "Cep83", "organism": "Rat", "refseq_name": "centrosomal protein of 83 kDa", "refseq_ac": [ { "id": "NP_001014288", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014288", "type": "external" } ], "gene_names_uniprotkb": "Cep83; Ccdc41", "gene_names_refseq": "Ccdc41; Cep83; RGD1359593", "protein_names_uniprotkb": "Centrosomal protein of 83 kDa; Cep83; Coiled-coil domain-containing protein 41", "protein_names_refseq": "centrosomal protein of 83 kDa; coiled-coil domain containing 41; coiled-coil domain-containing protein 41", "tax_id": 10116, "disease": "nephronophthisis 18 (Disease Ontology:DOID:0111125)", "pathway": " (rno:366872); (R-RNO-5620912)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005814 centriole;GO:0097539 ciliary transition fiber", "go_biological_process": "GO:0060271 cilium assembly;GO:0071539 protein localization to centrosome;GO:0048278 vesicle docking;GO:0051660 establishment of centrosome localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H89-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H94-1", "uniprot_id": [ { "id": "FKBP9_RAT", "url": "https://www.uniprot.org/uniprot/Q66H94", "type": "external" } ], "mass": 63127.0, "length": 570, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP9", "gene_name": "Fkbp9", "organism": "Rat", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP9 precursor", "refseq_ac": [ { "id": "NP_001007647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007647", "type": "external" } ], "gene_names_uniprotkb": "Fkbp9", "gene_names_refseq": "FKBP-9; Fkbp9", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP9; 5.2.1.8; FK506-binding protein 9; FKBP-9; PPIase FKBP9; Rotamase", "protein_names_refseq": "FK506 binding protein 9, 63 kDa; FK506-binding protein 9; PPIase FKBP9; peptidyl-prolyl cis-trans isomerase FKBP9 precursor; peptidyl-prolyl cis-trans isomerase FKBP9; rotamase", "tax_id": 10116, "disease": "", "pathway": " (rno:297123)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PPIases accelerate the folding of proteins during protein synthesis., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H94-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HC9-1", "uniprot_id": [ { "id": "DNAI2_RAT", "url": "https://www.uniprot.org/uniprot/Q66HC9", "type": "external" } ], "mass": 70318.0, "length": 619, "protein_name": "Dynein axonemal intermediate chain 2", "gene_name": "Dnai2", "organism": "Rat", "refseq_name": "dynein axonemal intermediate chain 2", "refseq_ac": [ { "id": "NP_001007727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007727", "type": "external" } ], "gene_names_uniprotkb": "Dnai2; Dnaic2", "gene_names_refseq": "Dnai2; Dnaic2", "protein_names_uniprotkb": "Dynein axonemal intermediate chain 2; Axonemal dynein intermediate chain 2", "protein_names_refseq": "axonemal dynein intermediate chain 2; dynein axonemal intermediate chain 2; dynein intermediate chain 2, axonemal; dynein, axonemal, intermediate polypeptide 2", "tax_id": 10116, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); primary ciliary dyskinesia 9 (Disease Ontology:DOID:0110622); sensorineural hearing loss (Disease Ontology:DOID:10003); primary ciliary dyskinesia (Disease Ontology:DOID:9562)", "pathway": " (rno:360654)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Part of the dynein complex of respiratory cilia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003777 microtubule motor activity;GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0009897 external side of plasma membrane;GO:0036126 sperm flagellum", "go_biological_process": "GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0003341 cilium movement;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HC9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FT1-1", "uniprot_id": [ { "id": "COQ9_RAT", "url": "https://www.uniprot.org/uniprot/Q68FT1", "type": "external" } ], "mass": 35146.0, "length": 312, "protein_name": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "gene_name": "Coq9", "organism": "Rat", "refseq_name": "ubiquinone biosynthesis protein COQ9, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001030334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030334", "type": "external" } ], "gene_names_uniprotkb": "Coq9", "gene_names_refseq": "Coq9", "protein_names_uniprotkb": "Ubiquinone biosynthesis protein COQ9, mitochondrial", "protein_names_refseq": "coenzyme Q9 homolog; ubiquinone biosynthesis protein COQ9, mitochondrial precursor; ubiquinone biosynthesis protein COQ9, mitochondrial", "tax_id": 10116, "disease": "coenzyme Q10 deficiency disease (Disease Ontology:DOID:0050730); primary coenzyme Q10 deficiency 5 (Disease Ontology:DOID:0070242)", "pathway": " (rno:498909); (R-RNO-2142789)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17824807;22673903", "class_list": "", "function": "Administration of simvastatin under the condition of nitric oxide-deficiency reduced the level of coenzyme Q9/10 in the heart and skeletal muscle., [RefSeq, PubMed]; Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to COQ7, therefore facilitating the COQ7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L109", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0042803 protein homodimerization activity;GO:0008289 lipid binding;GO:0019840 isoprenoid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0110142 ubiquinone biosynthesis complex", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q68FT1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FU1-1", "uniprot_id": [ { "id": "PKHF1_RAT", "url": "https://www.uniprot.org/uniprot/Q68FU1", "type": "external" } ], "mass": 31441.0, "length": 279, "protein_name": "Pleckstrin homology domain-containing family F member 1", "gene_name": "Plekhf1", "organism": "Rat", "refseq_name": "pleckstrin homology domain-containing family F member 1", "refseq_ac": [ { "id": "NP_001013166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013166", "type": "external" } ], "gene_names_uniprotkb": "Plekhf1", "gene_names_refseq": "Plekhf1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family F member 1; PH domain-containing family F member 1", "protein_names_refseq": "PH domain-containing family F member 1; pleckstrin homology domain containing, family F (with FYVE domain) member 1; pleckstrin homology domain-containing family F member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:308543)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in endosome function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0008270 zinc ion binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005769 early endosome;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006915 apoptotic process;GO:0007032 endosome organization;GO:0008333 endosome to lysosome transport;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FU1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXT9-1", "uniprot_id": [ { "id": "ODFP4_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXT9", "type": "external" } ], "mass": 33146.0, "length": 290, "protein_name": "Outer dense fiber protein 4", "gene_name": "Odf4", "organism": "Rat", "refseq_name": "outer dense fiber protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001007671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007671", "type": "external" } ], "gene_names_uniprotkb": "Odf4", "gene_names_refseq": "Odf4", "protein_names_uniprotkb": "Outer dense fiber protein 4; Outer dense fiber of sperm tails protein 4", "protein_names_refseq": "OPPO 1; outer dense fiber of sperm tails protein 4; outer dense fiber protein 4 isoform 2; outer dense fiber protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:303236)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001520 outer dense fiber;GO:0005886 plasma membrane;GO:0031514 motile cilium;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXT9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXU5-1", "uniprot_id": [ { "id": "CXL16_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXU5", "type": "external" } ], "mass": 27196.0, "length": 247, "protein_name": "C-X-C motif chemokine 16", "gene_name": "Cxcl16", "organism": "Rat", "refseq_name": "C-X-C motif chemokine 16 precursor", "refseq_ac": [ { "id": "NP_001017478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017478", "type": "external" } ], "gene_names_uniprotkb": "Cxcl16", "gene_names_refseq": "Cxcl16", "protein_names_uniprotkb": "C-X-C motif chemokine 16; Small-inducible cytokine B16; Transmembrane chemokine CXCL16", "protein_names_refseq": "C-X-C motif chemokine 16 precursor; C-X-C motif chemokine 16; chemokine (C-X-C motif) ligand 16; small-inducible cytokine B16; transmembrane chemokine CXCL16", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); systemic scleroderma (Disease Ontology:DOID:418)", "pathway": " (rno:497942); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15890643;19919988;29030988;35512476", "class_list": "", "function": "IL-18 induces CXCL16 expression via a MyD88, IRAK1-IRAK4-TRAF6, c-Src, PI3K, Akt, JNK, AP-1 pathway, [RefSeq, PubMed]; Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity)., [UniProtKB]; JNK and Jag1/Notch2 co-regulate CXCL16 to facilitate cypermethrin-induced kidney damage., [RefSeq, PubMed]; MiR-145-5p inhibited proliferation and inflammatory responses of RMCs through regulation of AKT/GSK pathway by targeting CXCL16, [RefSeq, PubMed]; Report increased production of CXCL16 in experimental heart failure: a possible role in extracellular matrix remodeling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005041 low-density lipoprotein particle receptor activity;GO:0008009 chemokine activity;GO:0042379 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration;GO:0034612 response to tumor necrosis factor;GO:0071222 cellular response to lipopolysaccharide;GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6AXU5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY34-1", "uniprot_id": [ { "id": "OSR2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY34", "type": "external" } ], "mass": 30513.0, "length": 276, "protein_name": "Protein odd-skipped-related 2", "gene_name": "Osr2", "organism": "Rat", "refseq_name": "protein odd-skipped-related 2 isoform 1", "refseq_ac": [ { "id": "NP_001012118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012118", "type": "external" } ], "gene_names_uniprotkb": "Osr2", "gene_names_refseq": "Osr2", "protein_names_uniprotkb": "Protein odd-skipped-related 2", "protein_names_refseq": "odd-skipped related 2; odd-skipped related transciption factor 2; protein odd-skipped-related 2 isoform 1; protein odd-skipped-related 2", "tax_id": 10116, "disease": "", "pathway": " (rno:315039)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in the development of the mandibular molar tooth germ at the bud stage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0033687 osteoblast proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY34-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY39-1", "uniprot_id": [ { "id": "B3GL1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY39", "type": "external" } ], "mass": 39215.0, "length": 331, "protein_name": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1", "gene_name": "B3galnt1", "organism": "Rat", "refseq_name": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 1", "refseq_ac": [ { "id": "NP_001013176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013176", "type": "external" } ], "gene_names_uniprotkb": "B3galnt1; B3galt3", "gene_names_refseq": "B3galnt1; B3galt3", "protein_names_uniprotkb": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1; 2.4.1.79; Beta-1,3-GalNAc-T1; Beta-1,3-GalTase 3; Beta-1,3-galactosyltransferase 3; Beta-3-Gx-T3; Beta3Gal-T3; Beta3GalT3; Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase; Globoside synthase; UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase; b3Gal-T3", "protein_names_refseq": "UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3; UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 1; UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1; UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase; b3Gal-T3; beta-1,3-GalNAc-T1; beta-1,3-GalTase 3; beta-1,3-galactosyltransferase 3; beta-3-GalNAc-T1; beta-3-Gx-T3; beta3Gal-T3; beta3GalT3; galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase; globoside synthase", "tax_id": 10116, "disease": "", "pathway": " (rno:310508); (R-RNO-9840309)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 4, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.79", "type": "external" } ], "go_molecular_function": "GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity;GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY39-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY47-1", "uniprot_id": [ { "id": "FICD_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY47", "type": "external" } ], "mass": 51754.0, "length": 458, "protein_name": "Protein adenylyltransferase FICD", "gene_name": "Ficd", "organism": "Rat", "refseq_name": "protein adenylyltransferase FICD", "refseq_ac": [ { "id": "NP_001010946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010946", "type": "external" } ], "gene_names_uniprotkb": "Ficd", "gene_names_refseq": "Ficd", "protein_names_uniprotkb": "Protein adenylyltransferase FICD; 2.7.7.108; 3.1.4.-; AMPylator FICD; De-AMPylase FICD; FIC domain-containing protein", "protein_names_refseq": "AMPylator FICD; FIC domain containing; FIC domain-containing protein; adenosine monophosphate-protein transferase FICD; de-AMPylase FICD; huntingtin interactor protein E; protein adenylyltransferase FICD", "tax_id": 10116, "disease": "hereditary spastic paraplegia 92 (Disease Ontology:DOID:0070644); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:288741)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (By similarity). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.7.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.108", "type": "external" } ], "go_molecular_function": "GO:0044603 protein adenylylhydrolase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:1903894 regulation of IRE1-mediated unfolded protein response;GO:0044602 protein deadenylylation;GO:0034976 response to endoplasmic reticulum stress;GO:0006986 response to unfolded protein;GO:0018117 protein adenylylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AY47-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY64-1", "uniprot_id": [ { "id": "CF120_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY64", "type": "external" } ], "mass": 20903.0, "length": 185, "protein_name": "UPF0669 protein C6orf120 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "UPF0669 protein C6orf120 homolog precursor", "refseq_ac": [ { "id": "NP_001096826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096826", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "C1h6orf120; C6orf120", "protein_names_uniprotkb": "UPF0669 protein C6orf120 homolog", "protein_names_refseq": "UPF0669 protein C6orf120 homolog precursor; UPF0669 protein C6orf120 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:100125364); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "34896761;38523410", "class_list": "", "function": "C6orf120 gene knockout in rats mitigates concanavalin Ainduced autoimmune hepatitis via regulating NKT cells., [RefSeq, PubMed]; May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes., [UniProtKB]; Novel protein C6ORF120 promotes liver fibrosis by activating hepatic stellate cells through the PI3K/Akt/mTOR pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AY64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY75-1", "uniprot_id": [ { "id": "PHF23_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY75", "type": "external" } ], "mass": 36232.0, "length": 334, "protein_name": "PHD finger protein 23", "gene_name": "Phf23", "organism": "Rat", "refseq_name": "PHD finger protein 23 isoform 2", "refseq_ac": [ { "id": "NP_001004272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004272", "type": "external" } ], "gene_names_uniprotkb": "Phf23", "gene_names_refseq": "Phf23", "protein_names_uniprotkb": "PHD finger protein 23; PDH-containing protein JUNE-1", "protein_names_refseq": "PDH-containing protein JUNE-1; PHD finger protein 23 isoform 2; PHD zinc finger containing protein JUNE1", "tax_id": 10116, "disease": "", "pathway": " (rno:360550)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:1901097 negative regulation of autophagosome maturation;GO:1902902 negative regulation of autophagosome assembly;GO:0006914 autophagy;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY75-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY91-1", "uniprot_id": [ { "id": "NRK1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY91", "type": "external" } ], "mass": 22321.0, "length": 195, "protein_name": "Nicotinamide riboside kinase 1", "gene_name": "Nmrk1", "organism": "Rat", "refseq_name": "nicotinamide riboside kinase 1", "refseq_ac": [ { "id": "NP_001019463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019463", "type": "external" } ], "gene_names_uniprotkb": "Nmrk1; Nrk1", "gene_names_refseq": "Nmrk1; Nrk1", "protein_names_uniprotkb": "Nicotinamide riboside kinase 1; 2.7.1.173; 2.7.1.22; NRK 1; Nicotinic acid riboside kinase 1; NmR-K 1; RNK 1; Ribosylnicotinamide kinase 1; Ribosylnicotinic acid kinase 1", "protein_names_refseq": "RNK 1; nicotinamide riboside kinase 1; nicotinic acid riboside kinase 1; nmR-K 1; ribosylnicotinamide kinase 1; ribosylnicotinic acid kinase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:499330); (R-RNO-196807)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.173", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.173", "type": "external" }, { "id": "2.7.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.22", "type": "external" } ], "go_molecular_function": "GO:0050262 ribosylnicotinamide kinase activity;GO:0061769 nicotinate riboside kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004634 phosphopyruvate hydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000015 phosphopyruvate hydratase complex", "go_biological_process": "GO:0006741 NADP+ biosynthetic process;GO:0034355 NAD+ biosynthetic process via the salvage pathway;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY91-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYA8-1", "uniprot_id": [ { "id": "PGKA1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYA8", "type": "external" } ], "mass": 33838.0, "length": 313, "protein_name": "PDCD10 and GCKIII kinases-associated protein 1", "gene_name": "Pgcka1", "organism": "Rat", "refseq_name": "PDCD10 and GCKIII kinases-associated protein 1", "refseq_ac": [ { "id": "NP_001017500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017500", "type": "external" } ], "gene_names_uniprotkb": "Pgcka1", "gene_names_refseq": "C14h4orf19; Pgcka1", "protein_names_uniprotkb": "PDCD10 and GCKIII kinases-associated protein 1", "protein_names_refseq": "ADP/ATP translocase 3-like; ADP/ATP translocase 3; PDCD10 and GCKIII kinases-associated protein 1; uncharacterized protein C4orf19 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:498368)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a tumor suppressor. Acts as a tumor suppressor for colorectal cancer cell proliferation by targeting KEAP1/USP17/ELK1/CDK6 axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6JDI0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYA8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYE5-1", "uniprot_id": [ { "id": "OAF_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYE5", "type": "external" } ], "mass": 31776.0, "length": 282, "protein_name": "Out at first protein homolog", "gene_name": "Oaf", "organism": "Rat", "refseq_name": "out at first protein homolog precursor", "refseq_ac": [ { "id": "NP_001014112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014112", "type": "external" } ], "gene_names_uniprotkb": "Oaf", "gene_names_refseq": "Oaf; RGD1305890", "protein_names_uniprotkb": "Out at first protein homolog", "protein_names_refseq": "OAF homolog; out at first protein homolog precursor; out at first protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:315594)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYE5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYH4-1", "uniprot_id": [ { "id": "CYREN_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYH4", "type": "external" } ], "mass": 17487.0, "length": 160, "protein_name": "Cell cycle regulator of non-homologous end joining", "gene_name": "Cyren", "organism": "Rat", "refseq_name": "cell cycle regulator of non-homologous end joining", "refseq_ac": [ { "id": "NP_001019496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019496", "type": "external" } ], "gene_names_uniprotkb": "Cyren; Mri", "gene_names_refseq": "Cyren; Mri", "protein_names_uniprotkb": "Cell cycle regulator of non-homologous end joining; Cell cycle regulator of NHEJ; Modulator of retrovirus infection homolog", "protein_names_refseq": "cell cycle regulator of non-homologous end joining; modulator of retrovirus infection homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500077)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17043244", "class_list": "", "function": "Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (By similarity). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present. Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination. Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (By similarity). In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination (By similarity). May also act as an indirect regulator of proteasome (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035861 site of double-strand break;GO:1990391 DNA repair complex", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0051260 protein homooligomerization;GO:0006974 DNA damage response;GO:0006303 double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYH4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYK9-1", "uniprot_id": [ { "id": "CDYL_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYK9", "type": "external" } ], "mass": 65031.0, "length": 589, "protein_name": "Chromodomain Y-like protein", "gene_name": "Cdyl", "organism": "Rat", "refseq_name": "chromodomain Y-like protein", "refseq_ac": [ { "id": "NP_001014167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014167", "type": "external" } ], "gene_names_uniprotkb": "Cdyl", "gene_names_refseq": "Cdyl", "protein_names_uniprotkb": "Chromodomain Y-like protein; 2.3.1.-; 4.2.1.-; CDY-like; Crotonyl-CoA hydratase; Putative tubulin acetyltransferase Cdyl", "protein_names_refseq": "CDY-like; chromodomain Y-like protein; chromodomain protein, Y chromosome-like; chromodomain protein, Y-like; crotonyl-CoA hydratase; putative tubulin acetyltransferase Cdyl", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:361237)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22673903;28681565;28842554;30665597;34888944", "class_list": "", "function": "Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (By similarity). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (By similarity). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (PubMed:28842554). In addition to acting as a chromatin reader, acts as a hydro-lyase. Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (By similarity). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). Displays acetyltransferase activity toward tubulin in vitro; such activity is however unsure in vivo and additional evidences would be required to confirm this result (PubMed:28681565)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Studies convincingly demonstrate the ability of CDYL to moonlight as a tubulin acetyltransferase., [RefSeq, PubMed]; The epigenetic factor CDYL regulates the gene expression of the voltage gated sodium channel, Nav1.6, which contributes to seizures in a rat model of epilepsy. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin ligase TRIM32 promotes dendrite arborization by mediating degradation of the epigenetic factor CDYL., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "4.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0003714 transcription corepressor activity;GO:0061628 histone H3K27me3 reader activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005694 chromosome", "go_biological_process": "GO:0060816 random inactivation of X chromosome;GO:0006351 DNA-templated transcription;GO:0007286 spermatid development;GO:0120094 negative regulation of peptidyl-lysine crotonylation;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6AYK9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYM1-1", "uniprot_id": [ { "id": "CE034_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYM1", "type": "external" } ], "mass": 72365.0, "length": 640, "protein_name": "Uncharacterized protein C5orf34 homolog", "gene_name": "C2h5orf34", "organism": "Rat", "refseq_name": "uncharacterized protein C5orf34 homolog", "refseq_ac": [ { "id": "NP_001014059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014059", "type": "external" } ], "gene_names_uniprotkb": "C2h5orf34", "gene_names_refseq": "C2h5orf34; RGD1306227", "protein_names_uniprotkb": "Uncharacterized protein C5orf34 homolog", "protein_names_refseq": "uncharacterized protein C5orf34 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:310377)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYM1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYT8-1", "uniprot_id": [ { "id": "MPZL1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYT8", "type": "external" } ], "mass": 29502.0, "length": 270, "protein_name": "Myelin protein zero-like protein 1", "gene_name": "Mpzl1", "organism": "Rat", "refseq_name": "myelin protein zero-like protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001007729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007729", "type": "external" } ], "gene_names_uniprotkb": "Mpzl1", "gene_names_refseq": "Mpzl1", "protein_names_uniprotkb": "Myelin protein zero-like protein 1", "protein_names_refseq": "myelin protein zero-like protein 1 isoform 1 precursor; myelin protein zero-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:360871)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. May be involved in regulation of integrin-mediated cell motility (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYT8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYU3-1", "uniprot_id": [ { "id": "DNJB6_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYU3", "type": "external" } ], "mass": 38922.0, "length": 357, "protein_name": "DnaJ homolog subfamily B member 6", "gene_name": "Dnajb6", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily B member 6", "refseq_ac": [ { "id": "NP_001013227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013227", "type": "external" } ], "gene_names_uniprotkb": "Dnajb6", "gene_names_refseq": "Dnajb6", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 6; HSJ-2; Heat shock protein J2; Hsp40 homolog; MRJ; MSJ-1", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 6; HSJ-2; MRJ; MSJ-1; dnaJ homolog subfamily B member 6; heat shock protein J2; hsp40 homolog", "tax_id": 10116, "disease": "autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305)", "pathway": " (rno:362293); (R-RNO-3371453)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11896048;26476842;29393594;9915854", "class_list": "", "function": "Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity., [UniProtKB, UniProtKB]; These results conclude that neurotoxicity resulting from elevated DNAJB6 is cell cycle dependent., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0060717 chorion development;GO:0030198 extracellular matrix organization;GO:0045892 negative regulation of DNA-templated transcription;GO:0050877 nervous system process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6AYU3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GMN2-1", "uniprot_id": [ { "id": "BAIP2_RAT", "url": "https://www.uniprot.org/uniprot/Q6GMN2", "type": "external" } ], "mass": 59183.0, "length": 535, "protein_name": "BAR/IMD domain-containing adapter protein 2", "gene_name": "Baiap2", "organism": "Rat", "refseq_name": "BAR/IMD domain-containing adapter protein 2", "refseq_ac": [ { "id": "NP_476544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476544", "type": "external" } ], "gene_names_uniprotkb": "Baiap2", "gene_names_refseq": "Baiap2; Irsp53", "protein_names_uniprotkb": "BAR/IMD domain-containing adapter protein 2; BAI-associated protein 2; BAI1-associated protein 2; Brain-specific angiogenesis inhibitor 1-associated protein 2; IRSp53; Insulin receptor substrate p53; Insulin receptor substrate protein of 53 kDa; Insulin receptor tyrosine kinase substrate protein p53", "protein_names_refseq": "BAI-associated protein 2; BAI1-associated protein 2; BAR/IMD domain-containing adapter protein 2; brain-specific angiogenesis inhibitor 1-associated protein 2-like; brain-specific angiogenesis inhibitor 1-associated protein 2; insulin receptor substrate 53; insulin receptor substrate p53; insulin receptor substrate protein of 53 kDa; insulin receptor tyrosine kinase substrate protein p53", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119)", "pathway": " (rno:117542); (R-RNO-2029482); (R-RNO-4420097); (R-RNO-5663213); (R-RNO-9013149); (R-RNO-9013423)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "11514062;11741283;15899863;22673903;25586189;29284046;33506012", "class_list": "", "function": "Adapter protein that links membrane-bound small G proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity)., [UniProtKB, UniProtKB]; Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions., [UniProtKB, UniProtKB, UniProtKB]; IRSp53 molecules may have a structural role organizing the Shank scaffold and/or linking the PSD to the actin cytoskeleton Publication Status: Online-Only, [RefSeq, PubMed]; Insulin Receptor Substrate p53 Ameliorates High-Glucose-Induced Activation of NF-kappaB and Impaired Mobility of HUVECs. Publication Status: Online-Only, [RefSeq, PubMed]; These findings suggest that SH2B1-IRSp53 complexes promote the formation of filopodia, neurite initiation, and neuronal branching., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q923H3", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0008093 cytoskeletal anchor activity;GO:0070064 proline-rich region binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0010976 positive regulation of neuron projection development;GO:0016358 dendrite development;GO:0032956 regulation of actin cytoskeleton organization;GO:0046847 filopodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6GMN2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6HA10-1", "uniprot_id": [ { "id": "GDF6_RAT", "url": "https://www.uniprot.org/uniprot/Q6HA10", "type": "external" } ], "mass": 51013.0, "length": 452, "protein_name": "Growth/differentiation factor 6", "gene_name": "Gdf6", "organism": "Rat", "refseq_name": "growth/differentiation factor 6 precursor", "refseq_ac": [ { "id": "NP_001013056", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013056", "type": "external" } ], "gene_names_uniprotkb": "Gdf6; Bmp13; Gdf16", "gene_names_refseq": "BMP-13; Gdf6; gdf16", "protein_names_uniprotkb": "Growth/differentiation factor 6; BMP-13; Bone morphogenetic protein 13; GDF-6; Growth/differentiation factor 16", "protein_names_refseq": "GDF-6; bone morphogenetic protein 13; growth differentiation factor 16; growth/differentiation factor 6 precursor", "tax_id": 10116, "disease": "isolated microphthalmia 4 (Disease Ontology:DOID:0060836); Klippel-Feil syndrome 1 (Disease Ontology:DOID:0080589); multiple synostoses syndrome 4 (Disease Ontology:DOID:0081320); Leber congenital amaurosis 17 (Disease Ontology:DOID:0110217); microphthalmia (Disease Ontology:DOID:10629); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (rno:252834)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12598543;21469182", "class_list": "", "function": "Expression regulated during tendon healing, [RefSeq, PubMed]; Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38., [UniProtKB, UniProtKB, UniProtKB]; Involved in the formation of periodontal ligament, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 1, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4X4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016477 cell migration;GO:0045666 positive regulation of neuron differentiation;GO:0006915 apoptotic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6HA10-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE08-1", "uniprot_id": [ { "id": "GGT6_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE08", "type": "external" } ], "mass": 51559.0, "length": 498, "protein_name": "Glutathione hydrolase 6", "gene_name": "Ggt6", "organism": "Rat", "refseq_name": "glutathione hydrolase 6", "refseq_ac": [ { "id": "NP_001002820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002820", "type": "external" } ], "gene_names_uniprotkb": "Ggt6", "gene_names_refseq": "Ggt6", "protein_names_uniprotkb": "Glutathione hydrolase 6; 2.3.2.2; 3.4.19.13; GGT 6; Gamma-glutamyltransferase 6; Gamma-glutamyltranspeptidase 6", "protein_names_refseq": "GGT 6; gamma-glutamyltransferase 6; gamma-glutamyltranspeptidase 6; glutathione hydrolase 6", "tax_id": 10116, "disease": "", "pathway": " (rno:408206); (R-RNO-174403); (R-RNO-5423646); (R-RNO-9753281)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.2", "type": "external" }, { "id": "3.4.19.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.13", "type": "external" }, { "id": "3.4.19.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.14", "type": "external" } ], "go_molecular_function": "GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006750 glutathione biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE08-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE75-1", "uniprot_id": [ { "id": "BACE2_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE75", "type": "external" } ], "mass": 55858.0, "length": 514, "protein_name": "Beta-secretase 2", "gene_name": "Bace2", "organism": "Rat", "refseq_name": "beta-secretase 2 precursor", "refseq_ac": [ { "id": "NP_001002802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002802", "type": "external" } ], "gene_names_uniprotkb": "Bace2", "gene_names_refseq": "Bace2", "protein_names_uniprotkb": "Beta-secretase 2; 3.4.23.45; Beta-site APP cleaving enzyme 2; Beta-site amyloid precursor protein cleaving enzyme 2; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase", "protein_names_refseq": "beta-secretase 2 precursor; beta-site APP-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; memapsin-1; membrane-associated aspartic protease 1; theta-secretase", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (rno:288227)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15060002;21073551;25342134", "class_list": "", "function": "Data show that astrocytes possess beta-secretase activity and produce amyloid-beta because of the activity of BACE2, but not BACE1, the expression of which is blocked at the translational level., [RefSeq, PubMed]; Found by global gene expression profiling that BACE2 was up-regulated in the rat pancreatic beta-cell line INS1E stably transfected with human IAPP gene, [RefSeq, PubMed]; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B2GVB0", "ec_number_list": [], "go_molecular_function": "GO:0008233 peptidase activity;GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0016485 protein processing;GO:0048143 astrocyte activation;GO:0050435 amyloid-beta metabolic process;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6IE75-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IMK0-1", "uniprot_id": [ { "id": "DPPA3_RAT", "url": "https://www.uniprot.org/uniprot/Q6IMK0", "type": "external" } ], "mass": 18834.0, "length": 158, "protein_name": "Developmental pluripotency-associated protein 3", "gene_name": "Dppa3", "organism": "Rat", "refseq_name": "developmental pluripotency-associated protein 3", "refseq_ac": [ { "id": "NP_001041329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041329", "type": "external" } ], "gene_names_uniprotkb": "Dppa3; Stella", "gene_names_refseq": "Dppa3", "protein_names_uniprotkb": "Developmental pluripotency-associated protein 3", "protein_names_refseq": "developmental pluripotency-associated protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:297576)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14654002", "class_list": "", "function": "Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001939 female pronucleus;GO:0000785 chromatin;GO:0001940 male pronucleus", "go_biological_process": "GO:0040016 embryonic cleavage;GO:0044726 epigenetic programing of female pronucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IMK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IN36-1", "uniprot_id": [ { "id": "WIPF1_RAT", "url": "https://www.uniprot.org/uniprot/Q6IN36", "type": "external" } ], "mass": 49751.0, "length": 487, "protein_name": "WAS/WASL-interacting protein family member 1", "gene_name": "Wipf1", "organism": "Rat", "refseq_name": "WAS/WASL-interacting protein family member 1", "refseq_ac": [ { "id": "NP_476540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476540", "type": "external" } ], "gene_names_uniprotkb": "Wipf1; Waspip; Wip", "gene_names_refseq": "Waspip; Wipf1; Wip", "protein_names_uniprotkb": "WAS/WASL-interacting protein family member 1; WASP-interacting protein; Wiskott-Aldrich syndrome protein-interacting protein", "protein_names_refseq": "WAS/WASL-interacting protein family member 1; WASP-interacting protein; Wiskott-Aldrich syndrome protein interacting protein; translation initiation factor IF-2-like; wiskott-Aldrich syndrome protein-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:117538); (R-RNO-2029482); (R-RNO-5663213)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11687573;17229736;22673903;29393594", "class_list": "", "function": "Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. Plays a role in the formation of cell ruffles (By similarity). May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation., [UniProtKB, PubMed]; WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VDA4", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0008093 cytoskeletal anchor activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0031410 cytoplasmic vesicle;GO:0001726 ruffle", "go_biological_process": "GO:0051707 response to other organism;GO:0046827 positive regulation of protein export from nucleus;GO:0030036 actin cytoskeleton organization;GO:0030048 actin filament-based movement;GO:0030029 actin filament-based process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6IN36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IUP3-1", "uniprot_id": [ { "id": "ELP5_RAT", "url": "https://www.uniprot.org/uniprot/Q6IUP3", "type": "external" } ], "mass": 35490.0, "length": 318, "protein_name": "Elongator complex protein 5", "gene_name": "Elp5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Elp5; Derp6; Rai12", "gene_names_refseq": "", "protein_names_uniprotkb": "Elongator complex protein 5; Dermal papilla-derived protein 6 homolog; Retinoic acid-induced protein 12", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287446)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in cell migration (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0033588 elongator holoenzyme complex", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0006400 tRNA modification;GO:0002098 tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6IUP3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IUR5-1", "uniprot_id": [ { "id": "NENF_RAT", "url": "https://www.uniprot.org/uniprot/Q6IUR5", "type": "external" } ], "mass": 18992.0, "length": 171, "protein_name": "Neudesin", "gene_name": "Nenf", "organism": "Rat", "refseq_name": "neudesin precursor", "refseq_ac": [ { "id": "NP_001002851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002851", "type": "external" } ], "gene_names_uniprotkb": "Nenf; Scirp10", "gene_names_refseq": "Nenf; SCIRP10; Spuf", "protein_names_uniprotkb": "Neudesin; Neuron-derived neurotrophic factor; SCIRP10-related protein; Spinal cord injury-related protein 10", "protein_names_refseq": "SCIRP10-related protein; Spinal cord injury related protein 10; neudesin precursor; neuron-derived neurotrophic factor; secreted protein of unknown function; spinal cord injury-related protein 10", "tax_id": 10116, "disease": "", "pathway": " (rno:289380)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31536960", "class_list": "", "function": "Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960). Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Also acts as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade;GO:0032099 negative regulation of appetite", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IUR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG12-1", "uniprot_id": [ { "id": "CF136_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG12", "type": "external" } ], "mass": 20445.0, "length": 172, "protein_name": "Uncharacterized protein C6orf136 homolog", "gene_name": "", "organism": "Rat", "refseq_name": "uncharacterized protein C6orf136 homolog", "refseq_ac": [ { "id": "NP_998775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998775", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "C20h6orf136; RGD1302996", "protein_names_uniprotkb": "Uncharacterized protein C6orf136 homolog", "protein_names_refseq": "hypothetical protein MGC:15854; uncharacterized protein C6orf136 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:294231)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MG12-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG14-1", "uniprot_id": [ { "id": "NRM_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG14", "type": "external" } ], "mass": 29382.0, "length": 262, "protein_name": "Nurim", "gene_name": "Nrm", "organism": "Rat", "refseq_name": "nurim", "refseq_ac": [ { "id": "NP_997673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997673", "type": "external" } ], "gene_names_uniprotkb": "Nrm; Ppp1r18", "gene_names_refseq": "Nrm", "protein_names_uniprotkb": "Nurim; Nuclear envelope membrane protein; Nuclear rim protein", "protein_names_refseq": "nuclear envelope membrane protein; nuclear rim protein; nurim", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (rno:361791)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MG14-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG71-1", "uniprot_id": [ { "id": "CTL4_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG71", "type": "external" } ], "mass": 78737.0, "length": 707, "protein_name": "Choline transporter-like protein 4", "gene_name": "Slc44a4", "organism": "Rat", "refseq_name": "choline transporter-like protein 4", "refseq_ac": [ { "id": "NP_997706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997706", "type": "external" } ], "gene_names_uniprotkb": "Slc44a4; Ctl4; Ng22; TPPT1", "gene_names_refseq": "Ng22; Slc44a4", "protein_names_uniprotkb": "Choline transporter-like protein 4; Solute carrier family 44 member 4; Thiamine pyrophosphate transporter 1", "protein_names_refseq": "choline transporter-like protein 4; thiamine pyrophosphate transporter 1", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 72 (Disease Ontology:DOID:0080268); sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (rno:294255); (R-RNO-1483191); (R-RNO-9958517)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15060004;15715662", "class_list": "", "function": "Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0015220 choline transmembrane transporter activity;GO:0090422 thiamine pyrophosphate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0008292 acetylcholine biosynthetic process;GO:0015871 choline transport;GO:0030974 thiamine pyrophosphate transmembrane transport;GO:0032475 otolith formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6MG71-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG81-1", "uniprot_id": [ { "id": "FKBPL_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG81", "type": "external" } ], "mass": 37960.0, "length": 347, "protein_name": "FK506-binding protein-like", "gene_name": "Fkbpl", "organism": "Rat", "refseq_name": "FK506-binding protein-like", "refseq_ac": [ { "id": "NP_001002818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002818", "type": "external" } ], "gene_names_uniprotkb": "Fkbpl", "gene_names_refseq": "Fkbpl", "protein_names_uniprotkb": "FK506-binding protein-like; WAF-1/CIP1 stabilizing protein 39; WISp39", "protein_names_refseq": "FK506 binding protein-like; FK506-binding protein-like; WAF-1/CIP1 stabilizing protein 39; WISp39", "tax_id": 10116, "disease": "", "pathway": " (rno:406168); (R-RNO-8852276)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0045765 regulation of angiogenesis;GO:1905553 regulation of blood vessel branching", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MG81-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG84-1", "uniprot_id": [ { "id": "EGFL8_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG84", "type": "external" } ], "mass": 31667.0, "length": 291, "protein_name": "Epidermal growth factor-like protein 8", "gene_name": "Egfl8", "organism": "Rat", "refseq_name": "epidermal growth factor-like protein 8 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001004070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004070", "type": "external" } ], "gene_names_uniprotkb": "Egfl8; Ng3", "gene_names_refseq": "Egfl8; Ng3", "protein_names_uniprotkb": "Epidermal growth factor-like protein 8; EGF-like protein 8", "protein_names_refseq": "EGF-like domain 8; EGF-like domain-containing protein 8; EGF-like protein 8; epidermal growth factor-like protein 8 isoform 1 precursor; epidermal growth factor-like protein 8; multiple EGF-like domain protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:406166)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0JPK1", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0001570 vasculogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MG84-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P0K8-1", "uniprot_id": [ { "id": "PLAK_RAT", "url": "https://www.uniprot.org/uniprot/Q6P0K8", "type": "external" } ], "mass": 81801.0, "length": 745, "protein_name": "Junction plakoglobin", "gene_name": "Jup", "organism": "Rat", "refseq_name": "junction plakoglobin", "refseq_ac": [ { "id": "NP_112309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112309", "type": "external" } ], "gene_names_uniprotkb": "Jup; Pg", "gene_names_refseq": "Jup", "protein_names_uniprotkb": "Junction plakoglobin", "protein_names_refseq": "gamma-catenin (plakoglobin); junction plakoglobin", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); cardiomyopathy (Disease Ontology:DOID:0050700); endometrial hyperplasia (Disease Ontology:DOID:0080365); Naxos disease (Disease Ontology:DOID:0080551); arrhythmogenic right ventricular dysplasia 12 (Disease Ontology:DOID:0110083); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); cancer (Disease Ontology:DOID:162); nephroblastoma (Disease Ontology:DOID:2154); ovarian cancer (Disease Ontology:DOID:2394); invasive ductal carcinoma (Disease Ontology:DOID:3008); carcinoma (Disease Ontology:DOID:305); palmoplantar keratosis (Disease Ontology:DOID:3390); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); epidermolytic hyperkeratosis (Disease Ontology:DOID:4603); neuropathy (Disease Ontology:DOID:870); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:81679); (R-RNO-418990); (R-RNO-5218920); (R-RNO-6798695); (R-RNO-6805567); (R-RNO-6809371); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013406); (R-RNO-9013407); (R-RNO-9762292); (R-RNO-9764561); (R-RNO-9766229); (R-RNO-9768727); (R-RNO-9958810); (R-RNO-9958825)", "pathway_count": 17, "publication_count": 8, "publication_id_list": "11125272;18683930;21617128;22673903;23747726;26858265;34502162;38843836", "class_list": "", "function": "Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity)., [UniProtKB, UniProtKB]; Gamma-Catenin regulates expression of HDAC4, but not HDAC1 and HDAC2 in Rat-K-Ras cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0045296 cadherin binding;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6P0K8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P686-1", "uniprot_id": [ { "id": "OSTF1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P686", "type": "external" } ], "mass": 23669.0, "length": 214, "protein_name": "Osteoclast-stimulating factor 1", "gene_name": "Ostf1", "organism": "Rat", "refseq_name": "osteoclast-stimulating factor 1", "refseq_ac": [ { "id": "NP_683690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683690", "type": "external" } ], "gene_names_uniprotkb": "Ostf1", "gene_names_refseq": "Ostf1; Sh3d3", "protein_names_uniprotkb": "Osteoclast-stimulating factor 1", "protein_names_refseq": "osteoclast-stimulating factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:259275); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3X7", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P686-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6Q6-1", "uniprot_id": [ { "id": "MTEF3_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6Q6", "type": "external" } ], "mass": 46666.0, "length": 409, "protein_name": "Transcription termination factor 3, mitochondrial", "gene_name": "Mterf3", "organism": "Rat", "refseq_name": "transcription termination factor 3, mitochondrial precursor", "refseq_ac": [ { "id": "NP_955419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955419", "type": "external" } ], "gene_names_uniprotkb": "Mterf3; Mterfd1", "gene_names_refseq": "Cgi12; Mterf3; Mterfd1", "protein_names_uniprotkb": "Transcription termination factor 3, mitochondrial; Mitochondrial transcription termination factor 3; mTERF domain-containing protein 1, mitochondrial; mTERF3", "protein_names_refseq": "MTERF domain containing 1; mTERF domain-containing protein 1, mitochondrial; transcription termination factor 3, mitochondrial precursor; transcription termination factor 3, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:299514); (R-RNO-5205685)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function. Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0061668 mitochondrial ribosome assembly;GO:1903108 regulation of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P6Q6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6R0-1", "uniprot_id": [ { "id": "LFG1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6R0", "type": "external" } ], "mass": 38594.0, "length": 348, "protein_name": "Protein lifeguard 1", "gene_name": "Grina", "organism": "Rat", "refseq_name": "protein lifeguard 1", "refseq_ac": [ { "id": "NP_695220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695220", "type": "external" } ], "gene_names_uniprotkb": "Grina; Lfg1; Nmdara1", "gene_names_refseq": "Grina", "protein_names_uniprotkb": "Protein lifeguard 1; Glutamate [NMDA] receptor-associated protein 1; NMDA receptor glutamate-binding subunit", "protein_names_refseq": "N-methyl-D-aspartate receptor glutamate-binding chain; NMDA receptor glutamate-binding chain; NMDA receptor glutamate-binding subunit; glutamate [NMDA] receptor-associated protein 1; glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding); protein lifeguard 1", "tax_id": 10116, "disease": "", "pathway": " (rno:266668)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potential apoptotic regulator., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0044325 transmembrane transporter binding;GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0043524 negative regulation of neuron apoptotic process;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0032469 endoplasmic reticulum calcium ion homeostasis;GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P6R0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P734-1", "uniprot_id": [ { "id": "IC1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P734", "type": "external" } ], "mass": 55611.0, "length": 504, "protein_name": "Plasma protease C1 inhibitor", "gene_name": "Serping1", "organism": "Rat", "refseq_name": "plasma protease C1 inhibitor precursor", "refseq_ac": [ { "id": "NP_954524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954524", "type": "external" } ], "gene_names_uniprotkb": "Serping1", "gene_names_refseq": "C1-IA; Serping1", "protein_names_uniprotkb": "Plasma protease C1 inhibitor; C1 Inh; C1 esterase inhibitor; C1-inhibiting factor; C1Inh; Serpin G1", "protein_names_refseq": "C1 Inh; C1 esterase inhibitor; C1-inactivator; C1-inhibiting factor; C1Inh; plasma protease C1 inhibitor precursor; plasma protease C1 inhibitor; serine (or cysteine) peptidase inhibitor, clade G, member 1; serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary); serpin G1; serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; serpin peptidase inhibitor, clade G, member 1", "tax_id": 10116, "disease": "familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); COVID-19 (Disease Ontology:DOID:0080600); hereditary angioedema type I (Disease Ontology:DOID:0080939); toxic shock syndrome (Disease Ontology:DOID:14115); hereditary angioedema (Disease Ontology:DOID:14735); angioedema (Disease Ontology:DOID:1558); glioblastoma (Disease Ontology:DOID:3068); cerebral infarction (Disease Ontology:DOID:3526); macular degeneration (Disease Ontology:DOID:4448); pancreatitis (Disease Ontology:DOID:4989); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:295703); (R-RNO-114608); (R-RNO-9769739); (R-RNO-977606); (R-RNO-9855719)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "26476955;29393594", "class_list": "", "function": "Serine protease inhibitor, which acrs as a regulator of the classical complement pathway. Forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May also regulate blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Suggest that endogenous C1-inhibitor is likely involved in the regulation of complement activity in the myocardium following acute myocardial infarction., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001869 negative regulation of complement activation, lectin pathway;GO:0007596 blood coagulation;GO:0042730 fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P734-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P742-1", "uniprot_id": [ { "id": "PLP2_RAT", "url": "https://www.uniprot.org/uniprot/Q6P742", "type": "external" } ], "mass": 16557.0, "length": 151, "protein_name": "Proteolipid protein 2", "gene_name": "Plp2", "organism": "Rat", "refseq_name": "proteolipid protein 2", "refseq_ac": [ { "id": "NP_997484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997484", "type": "external" } ], "gene_names_uniprotkb": "Plp2", "gene_names_refseq": "A4-LSB; Plp2", "protein_names_uniprotkb": "Proteolipid protein 2", "protein_names_refseq": "Proteolipid protein 2 (intestinal membrane A4 protein); proteolipid protein 2 (colonic epithelium-enriched); proteolipid protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:302562)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in cell differentiation in the intestinal epithelium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019956 chemokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P742-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P768-1", "uniprot_id": [ { "id": "B4GT3_RAT", "url": "https://www.uniprot.org/uniprot/Q6P768", "type": "external" } ], "mass": 44031.0, "length": 395, "protein_name": "Beta-1,4-galactosyltransferase 3", "gene_name": "B4galt3", "organism": "Rat", "refseq_name": "beta-1,4-galactosyltransferase 3", "refseq_ac": [ { "id": "NP_001009539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009539", "type": "external" } ], "gene_names_uniprotkb": "B4galt3", "gene_names_refseq": "B4galt3", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase 3; 2.4.1.-; 2.4.1.275; 2.4.1.38; 2.4.1.90; Beta-1,4-GalTase 3; Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; Beta4Gal-T3; N-acetyllactosamine synthase; Nal synthase; Neolactotriaosylceramide beta-1,4-galactosyltransferase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; b4Gal-T3", "protein_names_refseq": "N-acetyllactosamine synthase; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; b4Gal-T3; beta-1,4-GalTase 3; beta-1,4-galactosyltransferase 3; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; beta4Gal-T3; nal synthase; neolactotriaosylceramide beta-1,4-galactosyltransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:494342); (R-RNO-2022854); (R-RNO-975577)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.274", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.274", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" } ], "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945 N-acetyllactosamine synthase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006682 galactosylceramide biosynthetic process;GO:0006678 glucosylceramide metabolic process", "synthesized_glycan_count": 10105, "hit_score": 0.1, "record_id": "Q6P768-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7Q1-1", "uniprot_id": [ { "id": "BABA2_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7Q1", "type": "external" } ], "mass": 43559.0, "length": 383, "protein_name": "BRISC and BRCA1-A complex member 2", "gene_name": "Babam2", "organism": "Rat", "refseq_name": "BRISC and BRCA1-A complex member 2", "refseq_ac": [ { "id": "NP_954891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954891", "type": "external" } ], "gene_names_uniprotkb": "Babam2; Bre", "gene_names_refseq": "Babam2", "protein_names_uniprotkb": "BRISC and BRCA1-A complex member 2; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein", "protein_names_refseq": "BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; BRISC and BRCA1-A complex member 2; brain and reproductive organ-expressed (TNFRSF1A modulator); brain and reproductive organ-expressed protein", "tax_id": 10116, "disease": "", "pathway": " (rno:362704); (R-RNO-5689901); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-69473)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF signaling through its interactions with TNFRSF1A; however these effects may be indirect., [UniProtKB, UniProtKB]; May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070552 BRISC complex;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0006915 apoptotic process;GO:0006974 DNA damage response;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P7Q1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7Q4-1", "uniprot_id": [ { "id": "LGUL_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7Q4", "type": "external" } ], "mass": 20820.0, "length": 184, "protein_name": "Lactoylglutathione lyase", "gene_name": "Glo1", "organism": "Rat", "refseq_name": "lactoylglutathione lyase", "refseq_ac": [ { "id": "NP_997477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997477", "type": "external" } ], "gene_names_uniprotkb": "Glo1", "gene_names_refseq": "Glo1", "protein_names_uniprotkb": "Lactoylglutathione lyase; 4.4.1.5; Aldoketomutase; Glx I; Glyoxalase I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase", "protein_names_refseq": "S-D-lactoylglutathione methylglyoxal lyase; aldoketomutase; glx I; glyoxalase I; glyoxylase 1; ketone-aldehyde mutase; lactoylglutathione lyase; methylglyoxalase", "tax_id": 10116, "disease": "autistic disorder (Disease Ontology:DOID:12849); vascular disease (Disease Ontology:DOID:178); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:294320); (R-RNO-70268)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "24498315;27296676;28231326;28241483;31420161;8719777", "class_list": "", "function": "Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:8719777). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Required for normal osteoclastogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Data suggest that the high dynamics of glyoxalase 1 expression and distribution following neuronal injury may indicate a role of Glyoxalase 1. Publication Status: Online-Only, [RefSeq, PubMed]; Diabetes-induced impairment of arteriogenic adaptation can be partially rescued by overexpressing of GLO-I, indicating a role of AGEs in diabetes-induced impaired collateral formation, [RefSeq, PubMed]; Increased biosynthesis of collagens 1 and 4 was detected at mRNA and protein level following knockdown of glyoxalase 1 in L6 myoblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Knockdown of GLO1 promoted while overexpression of GLO1 prevented angiotensin II -induced cell proliferation and cell cycle transition in rat basilar smooth muscle cells., [RefSeq, PubMed]; These results show the importance of Glo-I as major detoxifying enzyme for methylglyoxal in cirrhosis. The reduced expression of Glo-I in cirrhosis demonstrates a possible explanation for increased inflammatory injury and suggests a 'vicious circle' in liver disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.4.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.5", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004462 lactoylglutathione lyase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0009438 methylglyoxal metabolic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6P7Q4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9Z8-1", "uniprot_id": [ { "id": "ORC4_RAT", "url": "https://www.uniprot.org/uniprot/Q6P9Z8", "type": "external" } ], "mass": 50105.0, "length": 434, "protein_name": "Origin recognition complex subunit 4", "gene_name": "Orc4", "organism": "Rat", "refseq_name": "origin recognition complex subunit 4", "refseq_ac": [ { "id": "NP_954523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954523", "type": "external" } ], "gene_names_uniprotkb": "Orc4; Orc4l", "gene_names_refseq": "Orc4", "protein_names_uniprotkb": "Origin recognition complex subunit 4", "protein_names_refseq": "origin recognition complex subunit 4", "tax_id": 10116, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); Meier-Gorlin syndrome 2 (Disease Ontology:DOID:0080513)", "pathway": " (rno:295596); (R-RNO-176187); (R-RNO-68616); (R-RNO-68689); (R-RNO-68949); (R-RNO-68962)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding;GO:0000166 nucleotide binding;GO:0016887 ATP hydrolysis activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005664 nuclear origin of replication recognition complex", "go_biological_process": "GO:0006260 DNA replication;GO:0051258 protein polymerization;GO:0006270 DNA replication initiation;GO:0040038 polar body extrusion after meiotic divisions", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P9Z8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q0N3-1", "uniprot_id": [ { "id": "NT5D2_RAT", "url": "https://www.uniprot.org/uniprot/Q6Q0N3", "type": "external" } ], "mass": 63653.0, "length": 553, "protein_name": "5'-nucleotidase domain-containing protein 2", "gene_name": "Nt5dc2", "organism": "Rat", "refseq_name": "5'-nucleotidase domain-containing protein 2", "refseq_ac": [ { "id": "NP_001009271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009271", "type": "external" } ], "gene_names_uniprotkb": "Nt5dc2", "gene_names_refseq": "Nt5dc2; RGD1305524", "protein_names_uniprotkb": "5'-nucleotidase domain-containing protein 2; 3.1.3.-", "protein_names_refseq": "5'-nucleotidase domain-containing protein 2; eye irido-corneal angle unknown protein", "tax_id": 10116, "disease": "", "pathway": " (rno:290558)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15326124;31279527;32778969;38382359", "class_list": "", "function": "Promotes dephosphorylation of tyrosine 3-monooxygenase TH which decreases TH catalytic activity and leads to reduced synthesis of catecholamines including dopamine, noradrenaline and adrenaline (PubMed:31279527, PubMed:32778969, PubMed:38382359). The exact mechanism of activity is unknown but may act as a phosphatase or promote the activity of phosphatases or may inhibit phosphorylation by acting as a barrier to interfere with protein kinase access (PubMed:32778969, PubMed:38382359)., [UniProtKB, PubMed, PubMed, PubMed]; These results indicate that NT5DC2 inhibited the synthesis of dopamine by decreasing the enzymatic activity of tyrosine hydroxylase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M7U9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008253 5'-nucleotidase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:1903180 negative regulation of dopamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6Q0N3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6W3B0-1", "uniprot_id": [ { "id": "DSG4_RAT", "url": "https://www.uniprot.org/uniprot/Q6W3B0", "type": "external" } ], "mass": 114367.0, "length": 1040, "protein_name": "Desmoglein-4", "gene_name": "Dsg4", "organism": "Rat", "refseq_name": "desmoglein-4 precursor", "refseq_ac": [ { "id": "NP_955784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955784", "type": "external" } ], "gene_names_uniprotkb": "Dsg4", "gene_names_refseq": "Dsg4", "protein_names_uniprotkb": "Desmoglein-4", "protein_names_refseq": "desmoglein-4 precursor", "tax_id": 10116, "disease": "hypotrichosis 6 (Disease Ontology:DOID:0110703); hypotrichosis (Disease Ontology:DOID:4535); alopecia (Disease Ontology:DOID:987)", "pathway": " (rno:291754); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "15081105;15606503;15617564;16382669;19683850;33995349", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). Plays a role in moderating lymphocyte migration to inflamed skin and maintaining homeostasis of the epidermal inflammatory response (PubMed:33995349)., [UniProtKB, UniProtKB, PubMed]; A large intragenic deletion encompassing nine exons of the desmoglein 4 gene underlies the skin phenotype in the Iffa Credo 'hairless' rat., [RefSeq, PubMed]; A spontaneous mutation in dsg4 underlies hypotrichosis in a new lanceolate hair rat model., [RefSeq, PubMed]; Cloning and identification of the rat Dsg4 gene, and identification of a missense mutation in a naturally occurring lanceolate hair (lah) rat mutant, [RefSeq, PubMed]; Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4. Publication Status: Online-Only, [RefSeq, PubMed]; Show that HOXC13, LEF1 and FOXN1 repress DSG4 transcription and provide in vitro and in vivo evidence correlating the Notch pathway with the activation and/or maintenance of DSG4 expression in the hair follicle., [RefSeq, PubMed]; We identified a homozygous missense mutation in the lanceolate (lah/lah) rat., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030057 desmosome", "go_biological_process": "GO:0007155 cell adhesion;GO:0030216 keratinocyte differentiation;GO:0098609 cell-cell adhesion;GO:0030509 BMP signaling pathway;GO:0001942 hair follicle development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6W3B0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XUX2-1", "uniprot_id": [ { "id": "DUSTY_RAT", "url": "https://www.uniprot.org/uniprot/Q6XUX2", "type": "external" } ], "mass": 104898.0, "length": 927, "protein_name": "Dual serine/threonine and tyrosine protein kinase", "gene_name": "Dstyk", "organism": "Rat", "refseq_name": "dual serine/threonine and tyrosine protein kinase", "refseq_ac": [ { "id": "NP_955750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955750", "type": "external" } ], "gene_names_uniprotkb": "Dstyk; Ripk5", "gene_names_refseq": "Dstyk; DustyPK; Ripk5", "protein_names_uniprotkb": "Dual serine/threonine and tyrosine protein kinase; 2.7.12.1; Dusty PK; Dusty protein kinase; Receptor-interacting serine/threonine-protein kinase 5", "protein_names_refseq": "dual serine/threonine and tyrosine protein kinase; dusty PK; dusty protein kinase; receptor interacting protein kinase 5; receptor-interacting serine/threonine-protein kinase 5", "tax_id": 10116, "disease": "congenital anomalies of the kidney and urinary tract 1 (Disease Ontology:DOID:0080206); hereditary spastic paraplegia 23 (Disease Ontology:DOID:0110774)", "pathway": " (rno:304791)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17123648", "class_list": "", "function": "Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0033674 positive regulation of kinase activity;GO:0044344 cellular response to fibroblast growth factor stimulus;GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6XUX2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Y1R5-1", "uniprot_id": [ { "id": "OXGR1_RAT", "url": "https://www.uniprot.org/uniprot/Q6Y1R5", "type": "external" } ], "mass": 38377.0, "length": 337, "protein_name": "2-oxoglutarate receptor 1", "gene_name": "Oxgr1", "organism": "Rat", "refseq_name": "2-oxoglutarate receptor 1", "refseq_ac": [ { "id": "NP_997471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997471", "type": "external" } ], "gene_names_uniprotkb": "Oxgr1; Gpr80; P2y15", "gene_names_refseq": "Gpr80; Oxgr1; P2Y15", "protein_names_uniprotkb": "2-oxoglutarate receptor 1; Alpha-ketoglutarate receptor 1; G protein-coupled receptor 80; P2Y purinoceptor 15; P2Y15", "protein_names_refseq": "2-oxoglutarate receptor 1; G protein-coupled receptor 80; P2Y purinoceptor 15; alpha-ketoglutarate receptor 1; oxoglutarate (alpha-ketoglutarate) receptor 1", "tax_id": 10116, "disease": "calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652)", "pathway": " (rno:290493); (R-RNO-373076); (R-RNO-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15001573", "class_list": "", "function": "G protein-coupled receptor for dicarboxylates and amino dicarboxylates. Receptor for itaconate, a metabolite produced by myeloid lineages. In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11 and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens (By similarity). Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation. Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens. Regulates mucin-producing goblet cell homeostasis (By similarity). Receptor for alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis. In an intrarenal paracrine signaling pathway, binds alpha-ketoglutarate and drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; P2Y15 is a cell surface receptor for AMP and adenosine, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045087 innate immune response;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6Y1R5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6YDN7-1", "uniprot_id": [ { "id": "CDC26_RAT", "url": "https://www.uniprot.org/uniprot/Q6YDN7", "type": "external" } ], "mass": 9802.0, "length": 85, "protein_name": "Anaphase-promoting complex subunit CDC26", "gene_name": "Cdc26", "organism": "Rat", "refseq_name": "anaphase-promoting complex subunit CDC26", "refseq_ac": [ { "id": "NP_001013258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013258", "type": "external" } ], "gene_names_uniprotkb": "Cdc26", "gene_names_refseq": "BWK-2; Cdc26", "protein_names_uniprotkb": "Anaphase-promoting complex subunit CDC26; Cell division cycle protein 26 homolog; Protein BWK-2", "protein_names_refseq": "anaphase-promoting complex subunit CDC26", "tax_id": 10116, "disease": "", "pathway": " (rno:366381); (R-RNO-141430); (R-RNO-174048); (R-RNO-174084); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-176407); (R-RNO-176408); (R-RNO-176412); (R-RNO-179409); (R-RNO-2467813); (R-RNO-2559582); (R-RNO-68867); (R-RNO-69017); (R-RNO-983168)", "pathway_count": 16, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). Together with the RING-H2 protein ANAPC11, forms the catalytic component of the E3 ubiquitin ligase complex (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6YDN7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6YFQ1-1", "uniprot_id": [ { "id": "CX6B2_RAT", "url": "https://www.uniprot.org/uniprot/Q6YFQ1", "type": "external" } ], "mass": 10472.0, "length": 88, "protein_name": "Cytochrome c oxidase subunit 6B2", "gene_name": "Cox6b2", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 6B2", "refseq_ac": [ { "id": "NP_001034174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034174", "type": "external" } ], "gene_names_uniprotkb": "Cox6b2", "gene_names_refseq": "Cox6b2", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6B2; COX VIb-2; Cytochrome c oxidase subunit VIb isoform 2; Cytochrome c oxidase subunit VIb, testis-specific isoform", "protein_names_refseq": "COX VIb-2; cytochrome c oxidase subunit 6B2; cytochrome c oxidase subunit VIb polypeptide 2", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (rno:654441); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "12874793", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045277 respiratory chain complex IV;GO:0030061 mitochondrial crista", "go_biological_process": "GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6YFQ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q75PQ8-1", "uniprot_id": [ { "id": "ORC2_RAT", "url": "https://www.uniprot.org/uniprot/Q75PQ8", "type": "external" } ], "mass": 65850.0, "length": 576, "protein_name": "Origin recognition complex subunit 2", "gene_name": "Orc2", "organism": "Rat", "refseq_name": "origin recognition complex subunit 2", "refseq_ac": [ { "id": "NP_001012003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012003", "type": "external" } ], "gene_names_uniprotkb": "Orc2; Orc2l", "gene_names_refseq": "Orc2l; Orc2", "protein_names_uniprotkb": "Origin recognition complex subunit 2", "protein_names_refseq": "origin recognition complex subunit 2", "tax_id": 10116, "disease": "", "pathway": " (rno:301430); (R-RNO-176187); (R-RNO-68616); (R-RNO-68689); (R-RNO-68949); (R-RNO-68962)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding", "go_cellular_component": "GO:0000939 inner kinetochore;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0000785 chromatin", "go_biological_process": "GO:0006270 DNA replication initiation;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q75PQ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76EI6-1", "uniprot_id": [ { "id": "FFAR2_RAT", "url": "https://www.uniprot.org/uniprot/Q76EI6", "type": "external" } ], "mass": 36994.0, "length": 330, "protein_name": "Free fatty acid receptor 2", "gene_name": "Ffar2", "organism": "Rat", "refseq_name": "free fatty acid receptor 2", "refseq_ac": [ { "id": "NP_001005877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005877", "type": "external" } ], "gene_names_uniprotkb": "Ffar2; Gpr43", "gene_names_refseq": "Ffar2; Gpr43", "protein_names_uniprotkb": "Free fatty acid receptor 2; G protein-coupled receptor 43", "protein_names_refseq": "G-protein coupled receptor 43; free fatty acid receptor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:292794); (R-RNO-416476); (R-RNO-444209)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "16453106;23589301;25310566;29369009;31728701;33754024;34216575", "class_list": "", "function": "By acting through GPR41 and 43, butyrate enhanced intracellular free cytosolic Ca2+. Gene-specific silencing of these receptors led to a partial inhibition of the butyrate-induced intracellular Ca2+ rise resulting in a decrease of hGH secretion. Publication Status: Online-Only, [RefSeq, PubMed]; Depends on the afferent colonic vagus nerve signaling and GPR41/43 receptors., [RefSeq, PubMed]; G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes., [UniProtKB, PubMed]; GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKalpha activity. Publication Status: Online-Only, [RefSeq, PubMed]; Short-chain fatty acid receptors involved in epithelial acetylcholine release in rat caecum., [RefSeq, PubMed]; The results suggest that the PYY-containing enteroendocrine cells and 5-HT-containing mucosal mast cells sense SCFAs via the GPR43 receptor., [RefSeq, PubMed]; These present data have shown for the first time that total mRNA isolation and protein expression from both adipose tissues (abdominal and subcutaneous) of rat in obesity condition yield significative statistical difference among the control versus obese groups, showing that the diet high in carbohydrates modifies the total presence of mRNA and protein level expression of the receptors GPR41, 43 and 120, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032722 positive regulation of chemokine production;GO:0042593 glucose homeostasis;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q76EI6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q792I0-1", "uniprot_id": [ { "id": "LIN7C_RAT", "url": "https://www.uniprot.org/uniprot/Q792I0", "type": "external" } ], "mass": 21834.0, "length": 197, "protein_name": "Protein lin-7 homolog C", "gene_name": "Lin7c", "organism": "Rat", "refseq_name": "protein lin-7 homolog C", "refseq_ac": [ { "id": "NP_068623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068623", "type": "external" } ], "gene_names_uniprotkb": "Lin7c; Mals3; Veli3", "gene_names_refseq": "Lin7c; MALS-3; Veli3", "protein_names_uniprotkb": "Protein lin-7 homolog C; Lin-7C; MALS-3; Mammalian lin-seven protein 3; Veli-3; Vertebrate lin-7 homolog 3", "protein_names_refseq": "lin-7 homolog C, crumbs cell polarity complex component; mammalian lin-seven protein 3; protein lin-7 homolog C; veli-3 protein; vertebrate lin-7 homolog 3", "tax_id": 10116, "disease": "", "pathway": " (rno:60442); (R-RNO-212676)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10341223;10362251;12040031;14960569;15024025;15494546;18403412;9753324", "class_list": "", "function": "MALS-3 plays a role in maintaining apicobasal polarity and is required for normal neurogenesis in the developing cortex., [RefSeq, PubMed]; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; Specific Veli isoforms participate in forming distinct protein complexes in brain, where Veli-1 stably associates with CASK and SAP97, Veli-2 associates with CASK and Mint1, and Veli-3 associates with CASK, SAP97, and Mint1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0008092 cytoskeletal protein binding;GO:0030165 PDZ domain binding;GO:0097016 L27 domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0015031 protein transport;GO:0007269 neurotransmitter secretion;GO:0006887 exocytosis;GO:0002011 morphogenesis of an epithelial sheet;GO:0048489 synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q792I0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNY1-1", "uniprot_id": [ { "id": "BACD2_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNY1", "type": "external" } ], "mass": 36046.0, "length": 316, "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2", "gene_name": "Tnfaip1", "organism": "Rat", "refseq_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2", "refseq_ac": [ { "id": "NP_891995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_891995", "type": "external" } ], "gene_names_uniprotkb": "Tnfaip1", "gene_names_refseq": "Edp1; Tnfaip1", "protein_names_uniprotkb": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; Tumor necrosis factor-induced protein 1", "protein_names_refseq": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; tumor necrosis factor, alpha induced protein 1; tumor necrosis factor, alpha-induced protein 1 (endothelial); tumor necrosis factor-induced protein 1", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:287543); (R-RNO-9696264); (R-RNO-9696270)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15726626;29115665;37217807", "class_list": "", "function": "LncRNA NKILA Exacerbates Alzheimer's Disease Progression by Regulating the FOXA1-Mediated Transcription of TNFAIP1., [RefSeq, PubMed]; Our current study indicates that XIST can positively regulate neuropathic pain in rats through regulating the expression of miR-137 and TNFAIP1. Our results imply that XIST/miR-137/TNFAIP1 axis may serve as a novel therapeutic target in neuropathic pain., [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis (By similarity). May enhance the PCNA-dependent DNA polymerase delta activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0006955 immune response;GO:0016477 cell migration;GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TNY1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNY6-1", "uniprot_id": [ { "id": "GCP60_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNY6", "type": "external" } ], "mass": 60479.0, "length": 526, "protein_name": "Golgi resident protein GCP60", "gene_name": "Acbd3", "organism": "Rat", "refseq_name": "Golgi resident protein GCP60", "refseq_ac": [ { "id": "NP_878263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_878263", "type": "external" } ], "gene_names_uniprotkb": "Acbd3; Gcp60", "gene_names_refseq": "Acbd3; DAP; GOCAP1; GOLPH1", "protein_names_uniprotkb": "Golgi resident protein GCP60; Acyl-CoA-binding domain-containing protein 3; DAP; DMT1-associated protein; GOCAP1; GOLPH1; Golgi complex-associated protein 1; Golgi phosphoprotein 1", "protein_names_refseq": "DMT1-associated protein; Golgi resident protein GCP60; acyl-CoA-binding domain-containing protein 3; acyl-Coenzyme A binding domain containing 3; golgi complex-associated protein 1; golgi phosphoprotein 1; neurotrophin receptor alike death domain protein; p75-like apoptosis-inducing death domain protein", "tax_id": 10116, "disease": "", "pathway": " (rno:289312); (R-RNO-432722)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006694 steroid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TNY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQM3-1", "uniprot_id": [ { "id": "FGRL1_RAT", "url": "https://www.uniprot.org/uniprot/Q7TQM3", "type": "external" } ], "mass": 57144.0, "length": 529, "protein_name": "Fibroblast growth factor receptor-like 1", "gene_name": "Fgfrl1", "organism": "Rat", "refseq_name": "fibroblast growth factor receptor-like 1 precursor", "refseq_ac": [ { "id": "NP_954545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954545", "type": "external" } ], "gene_names_uniprotkb": "Fgfrl1", "gene_names_refseq": "Fgfr5; Fgfrl1", "protein_names_uniprotkb": "Fibroblast growth factor receptor-like 1; FGF receptor-like protein 1", "protein_names_refseq": "FGF receptor-like protein 1; alpha-L-iduronidase; fibroblast growth factor receptor 5; fibroblast growth factor receptor-like 1 precursor; fibroblast growth factor receptor-like protein", "tax_id": 10116, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460)", "pathway": " (rno:360903); (R-RNO-5658623)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12813049;16019430;16804967;20938900", "class_list": "", "function": "Analysis of Fgf18 and Fgfr5 (Fgfrl1) expression in primary endothelial cells and vascular smooth muscle cells., [RefSeq, PubMed]; Downregulation of the FGFRL1 gene during the late stages of gestation may contribute to the development of the diaphragmatic defect in nitrofen-induced CDH Erratum:[Eur J Pediatr Surg. 2014 Aug;24(4):e5], [RefSeq, PubMed]; EGFR, FGFR and TNFR1 mRNA expression was equal or lower than in resting liver, HGFR expression after I/R was stronger than in the control., [RefSeq, PubMed]; Has a negative effect on cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8P8", "ec_number_list": [], "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030658 transport vesicle membrane;GO:0030133 transport vesicle", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0098609 cell-cell adhesion;GO:0001501 skeletal system development;GO:0060412 ventricular septum morphogenesis;GO:0060539 diaphragm development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7TQM3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQN4-1", "uniprot_id": [ { "id": "TF65_RAT", "url": "https://www.uniprot.org/uniprot/Q7TQN4", "type": "external" } ], "mass": 60267.0, "length": 550, "protein_name": "Transcription factor p65", "gene_name": "Rela", "organism": "Rat", "refseq_name": "transcription factor p65", "refseq_ac": [ { "id": "NP_954888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954888", "type": "external" } ], "gene_names_uniprotkb": "Rela; nos2", "gene_names_refseq": "NFkB; Rela; nos2", "protein_names_uniprotkb": "Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit", "protein_names_refseq": "nuclear factor NF-kappa-B p65 subunit; nuclear factor kappa B subunit p65; nuclear factor kappaB subunit p65; transcription factor p65; v-rel avian reticuloendotheliosis viral oncogene homolog A; v-rel reticuloendotheliosis viral oncogene homolog A", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); obstructive sleep apnea (Disease Ontology:DOID:0050848); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); lymphoma (Disease Ontology:DOID:0060058); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colitis (Disease Ontology:DOID:0060180); mastoiditis (Disease Ontology:DOID:0060322); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); bacterial infectious disease (Disease Ontology:DOID:104); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); primary biliary cholangitis (Disease Ontology:DOID:12236); uveitis (Disease Ontology:DOID:13141); renovascular hypertension (Disease Ontology:DOID:1591); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); arteriosclerosis (Disease Ontology:DOID:2349); prostate adenocarcinoma (Disease Ontology:DOID:2526); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); steatotic liver disease (Disease Ontology:DOID:9452); encephalitis (Disease Ontology:DOID:9588); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:309165); (R-RNO-1169091); (R-RNO-1810476); (R-RNO-193692); (R-RNO-202424); (R-RNO-209560); (R-RNO-2871837); (R-RNO-3134963); (R-RNO-3214841); (R-RNO-445989); (R-RNO-448706); (R-RNO-4755510); (R-RNO-5607764); (R-RNO-5621575); (R-RNO-9020702); (R-RNO-933542); (R-RNO-9860927); (R-RNO-9958825)", "pathway_count": 18, "publication_count": 11, "publication_id_list": "20737476;21904602;23312093;23457503;26407569;28688099;37493703;37976702;37980653;38679120;38710294", "class_list": "", "function": "Allograft inflammatory factor-1 enhances inflammation and oxidative stress via the NF-kappaB pathway of bladder urothelium in diabetic rat model., [RefSeq, PubMed]; Fengshi Liuhe Decoction treatment for rheumatoid arthritis via the Fzd6/NF-kappaB signaling axis., [RefSeq, PubMed]; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Besides its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells. The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection., [UniProtKB, UniProtKB]; Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150., [RefSeq, PubMed]; Role of cAMP/pCREB and GSK-3beta/NF-kappaB p65 signaling pathways in the renoprotective effect of mirabegron against renal ischemia-reperfusion injury in rats., [RefSeq, PubMed]; TIPE2 regulates periodontal inflammation by inhibiting NF-kappaB p65 phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 35, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1904385 cellular response to angiotensin;GO:0070498 interleukin-1-mediated signaling pathway;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7TQN4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSY2-1", "uniprot_id": [ { "id": "LHPL4_RAT", "url": "https://www.uniprot.org/uniprot/Q7TSY2", "type": "external" } ], "mass": 27050.0, "length": 247, "protein_name": "LHFPL tetraspan subfamily member 4 protein", "gene_name": "Lhfpl4", "organism": "Rat", "refseq_name": "LHFPL tetraspan subfamily member 4 protein", "refseq_ac": [ { "id": "NP_852052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852052", "type": "external" } ], "gene_names_uniprotkb": "Lhfpl4", "gene_names_refseq": "Lhfpl4", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 4 protein; Lipoma HMGIC fusion partner-like 4 protein", "protein_names_refseq": "HMGIC fusion partner-like protein 4; LHFPL tetraspan subfamily member 4 protein; lipoma HMGIC fusion partner-like 4 protein; lipoma HMGIC fusion partner-like protein 4", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 67 (Disease Ontology:DOID:0110518)", "pathway": " (rno:353230)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "28279354;28978485;29742426", "class_list": "", "function": "Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs., [UniProtKB, UniProtKB]; The results establish LHFPL4 as a synapse-specific tetraspanin essential for inhibitory synapse function and provide fresh insights into the molecular make-up of inhibitory synapses., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045211 postsynaptic membrane;GO:0060077 inhibitory synapse", "go_biological_process": "GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0007605 sensory perception of sound;GO:1905702 regulation of inhibitory synapse assembly;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7TSY2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P84-1", "uniprot_id": [ { "id": "PLCE1_RAT", "url": "https://www.uniprot.org/uniprot/Q99P84", "type": "external" } ], "mass": 255393.0, "length": 2281, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1", "gene_name": "Plce1", "organism": "Rat", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1", "refseq_ac": [ { "id": "NP_446210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446210", "type": "external" } ], "gene_names_uniprotkb": "Plce1; Plce", "gene_names_refseq": "Plce1; Plce", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; 3.1.4.11; PLC-epsilon-1; Phosphoinositide phospholipase C-epsilon-1; Phospholipase C-epsilon-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; PLC-epsilon-1; phosphoinositide phospholipase C-epsilon-1; phosphoinositide-specific phospholipase C epsilon-1", "tax_id": 10116, "disease": "nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); nephrotic syndrome type 3 (Disease Ontology:DOID:0080382); nephrotic syndrome (Disease Ontology:DOID:1184); gastric adenocarcinoma (Disease Ontology:DOID:3717)", "pathway": " (rno:114633); (R-RNO-1855204)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11179219;11641393;11788587;12721365;12900402;15322077;16314422;17086182;22673903;29885334;31217261;31433293;32796910;33662817", "class_list": "", "function": "PLCE1 promotes myocardial ischemia-reperfusion injury in H/R H9c2 cells and I/R rats by promoting inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; PLCepsilon1 mediates one-lung ventilation injury by regulating the p38/RhoA/NFkappaB activation loop., [RefSeq, PubMed]; Structure of phospholipase Cepsilon reveals an integrated RA1 domain and previously unidentified regulatory elements. Publication Status: Online-Only, [RefSeq, PubMed]; The authors demonstrate that endogenous beta1-adrenergic receptors at the Golgi apparatus in cardiac myocytes are required to stimulate hypertrophic Epac/PLCe-dependent phosphatidylinositol 4-phosphate hydrolysis at the Golgi, and that these intracellular beta1-adrenergic receptors can be accessed by physiological neurotransmitters, and synthetic b-blockers and agonists. Publication Status: Online-Only, [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; These results reveal distinct pools of cyclic nucleotides that either inhibit PLCepsilon at the Golgi through PKA/PKG, or activate PLCepsilon at the Golgi through Epac. These data together reveal a new mechanism by which ANF and selective PDE inhibitors can protect against cardiac hypertrophy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0004629 phospholipase C activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process;GO:0007265 Ras protein signal transduction;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q99P84-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QW07-1", "uniprot_id": [ { "id": "PLCB4_RAT", "url": "https://www.uniprot.org/uniprot/Q9QW07", "type": "external" } ], "mass": 134497.0, "length": 1175, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4", "gene_name": "Plcb4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Plcb4", "gene_names_refseq": "", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; 3.1.4.11; PLC-beta-4; Phosphoinositide phospholipase C-beta-4; Phospholipase C-beta-4", "protein_names_refseq": "", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); retinal disease (Disease Ontology:DOID:5679); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:25031); (R-RNO-112043); (R-RNO-1855204); (R-RNO-416476)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "22673903;7688223;8407970;9931434", "class_list": "", "function": "Activated phosphatidylinositol-specific phospholipase C enzymes catalyze the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) involved in G-protein coupled receptor signaling pathways. PLCB4 is a direct effector of the endothelin receptor signaling pathway that plays an essential role in lower jaw and middle ear structures development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88356;Q9Z0G6", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0051019 mitogen-activated protein kinase binding;GO:0005509 calcium ion binding;GO:0120548 phosphatidylinositol phospholipase C activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0051209 release of sequestered calcium ion into cytosol;GO:0043267 negative regulation of potassium ion transport;GO:0050804 modulation of chemical synaptic transmission;GO:0048015 phosphatidylinositol-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QW07-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JE6-1", "uniprot_id": [ { "id": "PLCB3_RAT", "url": "https://www.uniprot.org/uniprot/Q99JE6", "type": "external" } ], "mass": 139450.0, "length": 1234, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3", "gene_name": "Plcb3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Plcb3", "gene_names_refseq": "", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; 3.1.4.11; PLC-beta-3; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3", "protein_names_refseq": "", "tax_id": 10116, "disease": "spondylometaphyseal dysplasia with corneal dystrophy (Disease Ontology:DOID:0112303); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:29322); (R-RNO-112043); (R-RNO-1855204); (R-RNO-399997); (R-RNO-416476); (R-RNO-434316)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "11278298;15632121;22673903;8454637;9332346", "class_list": "", "function": "Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62887;Q9QW29", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005516 calmodulin binding;GO:0004629 phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0042383 sarcolemma;GO:0032991 protein-containing complex", "go_biological_process": "GO:0031161 phosphatidylinositol catabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0051209 release of sequestered calcium ion into cytosol;GO:0007208 phospholipase C-activating serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99JE6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QX67-1", "uniprot_id": [ { "id": "DAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QX67", "type": "external" } ], "mass": 11166.0, "length": 102, "protein_name": "Death-associated protein 1", "gene_name": "Dap", "organism": "Rat", "refseq_name": "death-associated protein 1", "refseq_ac": [ { "id": "NP_071971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071971", "type": "external" } ], "gene_names_uniprotkb": "Dap; Rap7a", "gene_names_refseq": "Dap; Rap7a", "protein_names_uniprotkb": "Death-associated protein 1; DAP-1; Rap7a", "protein_names_refseq": "DAP-1; death-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:64322)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation. Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation. Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "", "go_biological_process": "GO:0006915 apoptotic process;GO:0097190 apoptotic signaling pathway;GO:0006914 autophagy;GO:0010507 negative regulation of autophagy;GO:0141014 ribosome hibernation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QX67-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV87-1", "uniprot_id": [ { "id": "NOX1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WV87", "type": "external" } ], "mass": 65177.0, "length": 563, "protein_name": "NADPH oxidase 1", "gene_name": "Nox1", "organism": "Rat", "refseq_name": "NADPH oxidase 1", "refseq_ac": [ { "id": "NP_446135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446135", "type": "external" } ], "gene_names_uniprotkb": "Nox1; Mox1; Noh1", "gene_names_refseq": "Nox1", "protein_names_uniprotkb": "NADPH oxidase 1; 1.6.3.-; MOX-1; Mitogenic oxidase 1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NOH-1; NOX-1", "protein_names_refseq": "MOX-1; MOX1; NADH/NADPH mitogenic oxidase subunit p65-mox; NADPH oxidase 1; NOH-1; NOX-1; mitogenic oxidase 1", "tax_id": 10116, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary hypertension (Disease Ontology:DOID:6432); vascular dementia (Disease Ontology:DOID:8725); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:114243); (R-RNO-5668599); (R-RNO-9013149); (R-RNO-9013423)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10485709;24361341;25228390;33658472;34843718;35354309;37985248", "class_list": "", "function": "Advanced glycated end-products inhibit dilation through constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal muscle arteries., [RefSeq, PubMed]; CCR5 antagonist treatment inhibits vascular injury by regulating NADPH oxidase 1., [RefSeq, PubMed]; MiR-145-5p attenuates inflammatory response and apoptosis in myocardial ischemia-reperfusion injury by inhibiting (NADPH) oxidase homolog 1., [RefSeq, PubMed]; NADPH Oxidase 1 Mediates Acute Blood Pressure Response to Angiotensin II by Contributing to Calcium Influx in Vascular Smooth Muscle Cells., [RefSeq, PubMed]; NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0031267 small GTPase binding;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0016175 superoxide-generating NAD(P)H oxidase activity;GO:0106292 superoxide-generating NADPH oxidase activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0014043 negative regulation of neuron maturation;GO:0001525 angiogenesis;GO:0006952 defense response;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9WV87-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1H268-1", "uniprot_id": [ { "id": "MCMBP_RAT", "url": "https://www.uniprot.org/uniprot/B1H268", "type": "external" } ], "mass": 73007.0, "length": 642, "protein_name": "Mini-chromosome maintenance complex-binding protein", "gene_name": "Mcmbp", "organism": "Rat", "refseq_name": "mini-chromosome maintenance complex-binding protein", "refseq_ac": [ { "id": "NP_001034697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034697", "type": "external" } ], "gene_names_uniprotkb": "Mcmbp", "gene_names_refseq": "MCM-BP; Mcmbp; RGD1306730", "protein_names_uniprotkb": "Mini-chromosome maintenance complex-binding protein; MCM-BP; MCM-binding protein", "protein_names_refseq": "MCM-binding protein; mini-chromosome maintenance complex-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:309009)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0042555 MCM complex", "go_biological_process": "GO:0051301 cell division;GO:0007062 sister chromatid cohesion;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1H268-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU68-1", "uniprot_id": [ { "id": "PKHB1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WU68", "type": "external" } ], "mass": 25244.0, "length": 223, "protein_name": "Pleckstrin homology domain-containing family B member 1", "gene_name": "Plekhb1", "organism": "Rat", "refseq_name": "pleckstrin homology domain-containing family B member 1", "refseq_ac": [ { "id": "NP_742030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742030", "type": "external" } ], "gene_names_uniprotkb": "Plekhb1; Evt1; Kpl1", "gene_names_refseq": "Evt1; Kpl1; Plekhb1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family B member 1; Evectin-1; PH domain-containing family B member 1", "protein_names_refseq": "PH domain-containing family B member 1; evectin-1; pleckstrin homology domain containing, family B (evectins) member 1; pleckstrin homology domain-containing family B member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:64471)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10200314;10923244", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WU68-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MB5-1", "uniprot_id": [ { "id": "LMO3_RAT", "url": "https://www.uniprot.org/uniprot/Q99MB5", "type": "external" } ], "mass": 16624.0, "length": 145, "protein_name": "LIM domain only protein 3", "gene_name": "Lmo1; Lmo3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lmo1; Lmo3", "gene_names_refseq": "", "protein_names_uniprotkb": "LIM domain only protein 3; LMO-3; Neuronal-specific transcription factor DAT1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:245979); (R-RNO-8939236)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0046013 regulation of T cell homeostatic proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045600 positive regulation of fat cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q99MB5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0W1-1", "uniprot_id": [ { "id": "PITX2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0W1", "type": "external" } ], "mass": 35758.0, "length": 324, "protein_name": "Pituitary homeobox 2", "gene_name": "Pitx2", "organism": "Rat", "refseq_name": "pituitary homeobox 2 isoform 1", "refseq_ac": [ { "id": "NP_001035970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035970", "type": "external" } ], "gene_names_uniprotkb": "Pitx2; Ptx2", "gene_names_refseq": "Pitx-2; Pitx2c; Pitx2; Ptx2", "protein_names_uniprotkb": "Pituitary homeobox 2; Homeobox protein PITX2; Paired-like homeodomain transcription factor 2; rPtx2", "protein_names_refseq": "homeobox protein PITX2; paired-like homeodomain transcription factor 2; pituitary homeobox 2 isoform 1; pituitary homeobox 2; rPtx2", "tax_id": 10116, "disease": "Arts syndrome (Disease Ontology:DOID:0050647); X-linked Emery-Dreifuss muscular dystrophy 1 (Disease Ontology:DOID:0070246); anterior segment dysgenesis 4 (Disease Ontology:DOID:0080609); Axenfeld-Rieger syndrome type 1 (Disease Ontology:DOID:0110120); ring dermoid of cornea (Disease Ontology:DOID:0111548); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); dilated cardiomyopathy (Disease Ontology:DOID:12930); hypothyroidism (Disease Ontology:DOID:1459); Axenfeld-Rieger syndrome (Disease Ontology:DOID:14686); glaucoma (Disease Ontology:DOID:1686); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898)", "pathway": " (rno:54284)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11032870;24908044;35639924;9748586", "class_list": "", "function": "May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. Involved in the establishment of left-right asymmetry in the developing embryo., [UniProtKB, UniProtKB]; Pitx2 suppression at meiotic stages associates with seasonal inhibition of testis development in Rattus norvegicus caraco., [RefSeq, PubMed]; The present study suggests the presence of age-dependent left atrial Pitx2 down-regulation in SHRs, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060971 embryonic heart tube left/right pattern formation;GO:0003350 pulmonary myocardium development;GO:0003171 atrioventricular valve development;GO:0021763 subthalamic nucleus development;GO:0060577 pulmonary vein morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9R0W1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QX69-1", "uniprot_id": [ { "id": "LANC1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QX69", "type": "external" } ], "mass": 45240.0, "length": 399, "protein_name": "Glutathione S-transferase LANCL1", "gene_name": "Lancl1", "organism": "Rat", "refseq_name": "glutathione S-transferase LANCL1", "refseq_ac": [ { "id": "NP_446175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446175", "type": "external" } ], "gene_names_uniprotkb": "Lancl1; Gpr69a", "gene_names_refseq": "GPR69A; Lancl1; p40", "protein_names_uniprotkb": "Glutathione S-transferase LANCL1; 2.5.1.18; 40 kDa erythrocyte membrane protein; LanC-like protein 1; p40", "protein_names_refseq": "40 kDa erythrocyte membrane protein; LanC lantibiotic synthetase component C-like 1; LanC like 1; LanC-like 1(bacterial); glutathione S-transferase LANCL1; lanC (bacterial lantibiotic synthetase component C)-like 1; lanC-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:114515)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10944443;11376939;14514412;19528316;22673903;22891245;29393594", "class_list": "", "function": "Expression of LanCL1 mutants defective in Eps8 interaction inhibits nerve growth factor (NGF)-induced neurite outgrowth, [RefSeq, PubMed]; Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; LanC-like protein 1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse., [RefSeq, PubMed]; Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ER29", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0050750 low-density lipoprotein particle receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0031179 peptide modification;GO:1990748 cellular detoxification", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9QX69-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLS8-1", "uniprot_id": [ { "id": "OBRG_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLS8", "type": "external" } ], "mass": 14320.0, "length": 131, "protein_name": "Leptin receptor gene-related protein", "gene_name": "Leprot", "organism": "Rat", "refseq_name": "leptin receptor gene-related protein", "refseq_ac": [ { "id": "NP_064484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064484", "type": "external" } ], "gene_names_uniprotkb": "Leprot; Lepr; Obr", "gene_names_refseq": "Leprot; Ob-Rgrp; Obrgrp", "protein_names_uniprotkb": "Leptin receptor gene-related protein; Endospanin-1; OB-R gene-related protein; OB-RGRP", "protein_names_refseq": "OB-R gene-related protein; OB-receptor gene related protein (OB-RGRP); endospanin-1; leptin receptor gene-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:56766)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19907080;23772379;31841394", "class_list": "", "function": "Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin (By similarity). Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability., [UniProtKB, PubMed]; OB-RGRP regulated the phosphorylation of JAK2 and STAT3 in primary rat adipocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0010008 endosome membrane", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:2000009 negative regulation of protein localization to cell surface;GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JLS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K5E0-1", "uniprot_id": [ { "id": "LPAR3_RAT", "url": "https://www.uniprot.org/uniprot/Q8K5E0", "type": "external" } ], "mass": 40287.0, "length": 354, "protein_name": "Lysophosphatidic acid receptor 3", "gene_name": "Lpar3", "organism": "Rat", "refseq_name": "lysophosphatidic acid receptor 3", "refseq_ac": [ { "id": "NP_001426345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001426345", "type": "external" } ], "gene_names_uniprotkb": "Lpar3; Edg7; Lpa3", "gene_names_refseq": "Edg7; Lpar3", "protein_names_uniprotkb": "Lysophosphatidic acid receptor 3; LPA receptor 3; LPA-3; Lysophosphatidic acid receptor Edg-7; snGPCR32", "protein_names_refseq": "LPA receptor 3; LPA-3; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7; lysophosphatidic acid receptor 3; lysophosphatidic acid receptor Edg-7; putative G protein-coupled receptor snGPCR32; snGPCR32", "tax_id": 10116, "disease": "", "pathway": " (rno:66025); (R-RNO-416476); (R-RNO-418594); (R-RNO-419408)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "23711961;23790320;23867992;26473723;28922661", "class_list": "", "function": "Data showed that lysophosphatidic acid receptors LPA1-3, are phosphoproteins whose phosphorylation state is modulated by the natural agonist, LPA. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that signal transduction involving lysophosphatidic acid and Lpar3 is involved in uterine vascularization and decidualization, two main processes that prepare uterine milieu for embryo invasion during implantation., [RefSeq, PubMed]; Lysophosphatidic acid signaling through LPA3 may be involved in cell motile activity stimulated by ethionine in WB-F344 cells., [RefSeq, PubMed]; Pretreatment of primary hepatocytes with lysophosphatidic acid (LPA) resulted in an inhibition of insulin-mediated Gck expression, PI3K activation and glycogen synthesis. Pharmacological approaches revealed that the LPA3-receptor subtype is responsible for the inhibitory effect of LPA on insulin signaling., [RefSeq, PubMed]; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins (By similarity)., [UniProtKB]; These findings identified opposite subtype-specific functions for LPA1 and LPA3 in mediating cardiomyocyte hypertrophy and indicated LPA1 to be a target of miR-23a, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9ESJ6", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005543 phospholipid binding;GO:0001965 G-protein alpha-subunit binding;GO:0070915 lysophosphatidic acid receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0032060 bleb assembly;GO:0051928 positive regulation of calcium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8K5E0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R012-1", "uniprot_id": [ { "id": "PLK2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R012", "type": "external" } ], "mass": 77920.0, "length": 682, "protein_name": "Serine/threonine-protein kinase PLK2", "gene_name": "Plk2", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase PLK2", "refseq_ac": [ { "id": "NP_114009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114009", "type": "external" } ], "gene_names_uniprotkb": "Plk2; Snk", "gene_names_refseq": "Plk2; Snk", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK2; 2.7.11.21; PLK-2; Polo-like kinase 2; Serine/threonine-protein kinase SNK; Serum-inducible kinase", "protein_names_refseq": "PLK-2; polo-like kinase 1; serine/threonine-protein kinase PLK2; serine/threonine-protein kinase SNK; serum-inducible kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:83722); (R-RNO-6804115)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10523297;18498738;18723513;20802490;21382555;29066438;29393594;31134620;34047419;37654026", "class_list": "", "function": "Overexpression of PLK2 reverses the effect of upregulation of miR-27a on synovial angiogenesis and chondrocyte injury in KOA rats. Our study suggests that upregulation of miR-27a inhibits synovial angiogenesis and chondrocyte apoptosis in KOA rats through the inhibition of PLK2., [RefSeq, PubMed]; PLK2 protects retinal ganglion cells from oxidative stress by potentiating Nrf2 signaling via GSK-3beta., [RefSeq, PubMed]; Plk2 acts as coordinator of cell proliferation and early lineage commitment in cardiac progenitor cells downstream of Yes-associated protein 1. Publication Status: Online-Only, [RefSeq, PubMed]; Plk2 promotes synaptic destabilization through disruption of N-cadherin adhesion complexes during homeostatic adaptation to hyperexcitation., [RefSeq, PubMed]; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CPAP, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CPAP and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0051117 ATPase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030425 dendrite", "go_biological_process": "GO:0032486 Rap protein signal transduction;GO:0000278 mitotic cell cycle;GO:0006468 protein phosphorylation;GO:0007613 memory;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9R012-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JXT6-1", "uniprot_id": [ { "id": "MTMR6_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JXT6", "type": "external" } ], "mass": 75577.0, "length": 655, "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6", "gene_name": "Mtmr6", "organism": "Rat", "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform 1", "refseq_ac": [ { "id": "NP_001381640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381640", "type": "external" } ], "gene_names_uniprotkb": "Mtmr6", "gene_names_refseq": "Mtmr6", "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6; 3.1.3.95; Myotubularin-related protein 6; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6 isoform 1; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 10116, "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); centronuclear myopathy (Disease Ontology:DOID:14717)", "pathway": " (rno:305935); (R-RNO-1660499)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;23188820", "class_list": "", "function": "Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (By similarity). Negatively regulates ER-Golgi protein transport (PubMed:23188820). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm;GO:0032587 ruffle membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0046856 phosphatidylinositol dephosphorylation;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2JXT6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924S1-1", "uniprot_id": [ { "id": "PLCD_RAT", "url": "https://www.uniprot.org/uniprot/Q924S1", "type": "external" } ], "mass": 43794.0, "length": 378, "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase delta", "gene_name": "Agpat4", "organism": "Rat", "refseq_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase delta", "refseq_ac": [ { "id": "NP_596897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596897", "type": "external" } ], "gene_names_uniprotkb": "Agpat4", "gene_names_refseq": "Agpat4", "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase delta; 1-AGP acyltransferase 4; 1-AGPAT 4; 1-acylglycerol-3-phosphate O-acyltransferase 4; 2.3.1.51; LPAAT-delta; Lysophosphatidic acid acyltransferase delta", "protein_names_refseq": "1-AGP acyltransferase 4; 1-AGPAT 4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, delta); 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta); LPAAT-delta; lysophosphatidic acid acyltransferase delta", "tax_id": 10116, "disease": "", "pathway": " (rno:170919); (R-RNO-1483166)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0042171 lysophosphatidic acid acyltransferase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006644 phospholipid metabolic process;GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q924S1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JD3-1", "uniprot_id": [ { "id": "ODC_RAT", "url": "https://www.uniprot.org/uniprot/Q99JD3", "type": "external" } ], "mass": 33279.0, "length": 298, "protein_name": "Mitochondrial 2-oxodicarboxylate carrier", "gene_name": "Slc25a21", "organism": "Rat", "refseq_name": "mitochondrial 2-oxodicarboxylate carrier", "refseq_ac": [ { "id": "NP_598298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598298", "type": "external" } ], "gene_names_uniprotkb": "Slc25a21; Odc", "gene_names_refseq": "Odc1; Slc25a21", "protein_names_uniprotkb": "Mitochondrial 2-oxodicarboxylate carrier; Solute carrier family 25 member 21", "protein_names_refseq": "mitochondrial 2-oxodicarboxylate carrier; oxodicarboxylate carrier; solute carrier family 25 (mitochondrial oxoadipate carrier), member 21; solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21", "tax_id": 10116, "disease": "mitochondrial DNA depletion syndrome 18 (Disease Ontology:DOID:0070449)", "pathway": " (rno:171151); (R-RNO-71064)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11083877", "class_list": "", "function": "Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006869 lipid transport;GO:1990550 mitochondrial alpha-ketoglutarate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99JD3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K5A9-1", "uniprot_id": [ { "id": "NRADD_RAT", "url": "https://www.uniprot.org/uniprot/Q8K5A9", "type": "external" } ], "mass": 24400.0, "length": 228, "protein_name": "Death domain-containing membrane protein NRADD", "gene_name": "Nradd", "organism": "Rat", "refseq_name": "death domain-containing membrane protein NRADD", "refseq_ac": [ { "id": "NP_640352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_640352", "type": "external" } ], "gene_names_uniprotkb": "Nradd; Nrh2; Plaidd", "gene_names_refseq": "NRH2; Nradd; PLAIDD", "protein_names_uniprotkb": "Death domain-containing membrane protein NRADD; NRH2; Neurotrophin receptor homolog-2; Neurotrophin receptor-alike death domain protein; P75-like apoptosis-inducing death domain protein; PLAIDD", "protein_names_refseq": "death domain-containing membrane protein NRADD; neurotrophin receptor homolog-2; neurotrophin receptor-alike death domain protein; p75-like apoptosis-inducing death domain protein PLAIDD", "tax_id": 10116, "disease": "", "pathway": " (rno:246143)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12095158;12728256;19407813", "class_list": "", "function": "Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR (By similarity). Both isoform 1 and isoform 2 promote apoptosis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "G3V8U7;Q8K5A8", "ec_number_list": [], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0015026 coreceptor activity;GO:0005166 neurotrophin p75 receptor binding;GO:0005035 death receptor activity", "go_cellular_component": "GO:0032589 neuron projection membrane;GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006915 apoptotic process;GO:0007266 Rho protein signal transduction;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K5A9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A1F2-3", "uniprot_id": [ { "id": "MICA2_RAT", "url": "https://www.uniprot.org/uniprot/D4A1F2", "type": "external" } ], "mass": 217484.0, "length": 1948, "protein_name": "[F-actin]-monooxygenase MICAL2", "gene_name": "Mical2", "organism": "Rat", "refseq_name": "[F-actin]-monooxygenase MICAL2 isoform 2", "refseq_ac": [ { "id": "NP_001132980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001132980", "type": "external" } ], "gene_names_uniprotkb": "Mical2; Micalcl", "gene_names_refseq": "Mical-2; Mical2; Micalcl; RGD1311773; RSB-11-77", "protein_names_uniprotkb": "[F-actin]-monooxygenase MICAL2; 1.14.13.225; MICAL C-terminal-like protein; MICAL-2; Mical-cL; Molecule interacting with CasL protein 2; Protein RSB-11-77", "protein_names_refseq": "ERK2-binding testicular protein 1; F-actin-monooxygenase MICAL2; MICAL C-terminal like; MICAL C-terminal-like protein; [F-actin]-methionine sulfoxide oxidase MICAL2; [F-actin]-monooxygenase MICAL2 isoform 2; [F-actin]-monooxygenase MICAL2; ebitein-1; mical-cL; molecule interacting with CasL protein 2; protein MICAL-2; protein-methionine sulfoxide oxidase MICAL2", "tax_id": 10116, "disease": "", "pathway": " (rno:365352)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16230022;22673903", "class_list": "", "function": "Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Tesults implicate MICALs in neuronal regeneration and support the possibility to attenuate axon repulsion in the injured spinal cord., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LW55;Q498N8;Q4G091;Q80WN5", "ec_number_list": [ { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" } ], "go_molecular_function": "GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0071949 FAD binding;GO:0051019 mitogen-activated protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030036 actin cytoskeleton organization;GO:0007010 cytoskeleton organization;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A1F2-3", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3E7-1", "uniprot_id": [ { "id": "DPY30_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3E7", "type": "external" } ], "mass": 11201.0, "length": 99, "protein_name": "Protein dpy-30 homolog", "gene_name": "Dpy30", "organism": "Rat", "refseq_name": "protein dpy-30 homolog", "refseq_ac": [ { "id": "NP_775140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775140", "type": "external" } ], "gene_names_uniprotkb": "Dpy30; Aip1", "gene_names_refseq": "Aip1; Dpy30", "protein_names_uniprotkb": "Protein dpy-30 homolog; Dpy-30-like protein; Dpy-30L; Protein rAIP1", "protein_names_refseq": "dpy-30 homolog; dpy-30-like protein; dpy-30L; protein dpy-30 homolog; protein rAIP1", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:286897)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19651892", "class_list": "", "function": "As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity)., [UniProtKB]; The mDpy-30 functions in the endosome to trans-Golgi network transport of cation-independent mannose 6-phosphate receptor(CIMPR)and that its knockdown results in the enrichment of internalized CIMPR and recycling endosomes near cell protrusions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005802 trans-Golgi network;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0016197 endosomal transport;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K3E7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZH2-1", "uniprot_id": [ { "id": "BARD1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZH2", "type": "external" } ], "mass": 84548.0, "length": 768, "protein_name": "BRCA1-associated RING domain protein 1", "gene_name": "Bard1", "organism": "Rat", "refseq_name": "BRCA1-associated RING domain protein 1", "refseq_ac": [ { "id": "NP_072144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072144", "type": "external" } ], "gene_names_uniprotkb": "Bard1", "gene_names_refseq": "Bard1", "protein_names_uniprotkb": "BRCA1-associated RING domain protein 1; 2.3.2.27; BARD-1; RING-type E3 ubiquitin transferase BARD1", "protein_names_refseq": "BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:64557); (R-RNO-5685938); (R-RNO-5685942); (R-RNO-5689603); (R-RNO-5689901); (R-RNO-5693537); (R-RNO-5693565); (R-RNO-5693568); (R-RNO-5693571); (R-RNO-5693579); (R-RNO-5693607); (R-RNO-5693616); (R-RNO-6804756); (R-RNO-69473)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "11156388;11856892", "class_list": "", "function": "Assignment of the BRCA1-associated RING domain gene (Bard1) to rat chromosome 9q34 by in situ hybridization and radiation hybrid mapping, [RefSeq, PubMed]; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.1.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0006281 DNA repair;GO:0007283 spermatogenesis;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process;GO:0071394 cellular response to testosterone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZH2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2F5-1", "uniprot_id": [ { "id": "CTBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2F5", "type": "external" } ], "mass": 46628.0, "length": 430, "protein_name": "C-terminal-binding protein 1", "gene_name": "Ctbp1", "organism": "Rat", "refseq_name": "C-terminal-binding protein 1", "refseq_ac": [ { "id": "NP_062074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062074", "type": "external" } ], "gene_names_uniprotkb": "Ctbp1; Bars; Ctbp3", "gene_names_refseq": "50-kDaBFA-inducedADP-ribosylatedsubstrate; BARS-50; Bars; CtBP3/BARS; Ctbp1", "protein_names_uniprotkb": "C-terminal-binding protein 1; 1.1.1.-; 50 kDa BFA-dependent ADP-ribosylation substrate; BARS-50; C-terminal-binding protein 3; CtBP1; CtBP3", "protein_names_refseq": "50 kDa BFA-dependent ADP-ribosylation substrate; 50-kDa BFA-induced ADP-ribosylated substrate; C-terminal-binding protein 1; C-terminal-binding protein 3; C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate; brefeldin A-ADP-riboslyated substrate; ctBP3", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); isolated growth hormone deficiency type II (Disease Ontology:DOID:0060872); osteoporosis (Disease Ontology:DOID:11476); alcohol use disorder (Disease Ontology:DOID:1574); primary ovarian insufficiency (Disease Ontology:DOID:5426); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:29382); (R-RNO-3769402); (R-RNO-3899300); (R-RNO-4641265); (R-RNO-9764725)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "10364211;11864595;12805226;16940172;18683930;19351597;25652077;28408745;31340205;7624370", "class_list": "", "function": "CTBP1 Confers Protection for Hippocampal and Cortical Neurons in Rat Models of Alzheimer's Disease., [RefSeq, PubMed]; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; CtBp proteins repress transcription in a histone deacetylase dependent or independent manner. Review article, [RefSeq, PubMed]; Results shed light on the binding of CtBP1 protein to SUMOylated Foxp1 to repress the genetic transcription and drive dendritic morphogenesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9Z2F5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPI9-1", "uniprot_id": [ { "id": "LR74A_RAT", "url": "https://www.uniprot.org/uniprot/A0JPI9", "type": "external" } ], "mass": 53227.0, "length": 479, "protein_name": "Leucine-rich repeat-containing protein 74A", "gene_name": "Lrrc74a", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 74A", "refseq_ac": [ { "id": "NP_001032872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032872", "type": "external" } ], "gene_names_uniprotkb": "Lrrc74a; Lrrc74", "gene_names_refseq": "Lrrc74a; Lrrc74", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 74A; Leucine-rich repeat-containing protein 74", "protein_names_refseq": "leucine rich repeat containing 74; leucine-rich repeat-containing protein 74A; leucine-rich repeat-containing protein 74; uncharacterized protein C14orf166B homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:314328)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KLZ5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JPI9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ31-1", "uniprot_id": [ { "id": "CUL5_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJ31", "type": "external" } ], "mass": 90890.0, "length": 780, "protein_name": "Cullin-5", "gene_name": "Cul5", "organism": "Rat", "refseq_name": "cullin-5", "refseq_ac": [ { "id": "NP_073174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073174", "type": "external" } ], "gene_names_uniprotkb": "Cul5; Vacm1", "gene_names_refseq": "Cul5", "protein_names_uniprotkb": "Cullin-5; CUL-5; VACM-1; Vasopressin-activated calcium-mobilizing receptor 1", "protein_names_refseq": "CUL-5; VACM-1; cullin-5; vasopressin-activated calcium-mobilizing receptor 1; vasopressin-activated calcium-mobilizing receptor protein", "tax_id": 10116, "disease": "", "pathway": " (rno:64624); (R-RNO-8863795); (R-RNO-8951664); (R-RNO-9705462); (R-RNO-983168)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "10849213;11794467;12631466;22581383;23171819", "class_list": "", "function": "Core component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Acts a scaffold protein that contributes to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable SOCS box-containing substrate recognition component (By similarity). Acts as a key regulator of neuron positioning during cortex development: component of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (By similarity). ECS(SOCS1) seems to direct ubiquitination of JAK2. The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR. The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS. ECS(KLHDC1) complex is part of the DesCEND (destruction via C-end degrons) pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine. The ECS(ASB9) complex mediates ubiquitination and degradation of CKB. As part of some ECS complex, promotes 'Lys-11'-linked ubiquitination and degradation of BTRC. As part of a multisubunit ECS complex, polyubiquitinates monoubiquitinated POLR2A. As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration. As part of the ECS(RAB40A) complex, mediates RHOU 'Lys-48'-linked ubiquitination and degradation, thus inhibiting focal adhesion disassembly during cell migration. As part of the ECS(RAB40B) complex, mediates LIMA1/EPLIN and RAP2 ubiquitination, thereby regulating actin cytoskeleton dynamics and stress fiber formation during cell migration. The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1. As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism. May form a cell surface vasopressin receptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Cullin-5 mRNA levels are significantly increased in the rat cerebral cortex, hypothalamus and kidney following 48 h of water deprivation., [RefSeq, PubMed]; The data demonstrate that VACM-1 is involved in the regulation of AQP2 protein concentration and may play a role in regulating water balance., [RefSeq, PubMed]; Transcript encoding vasopressin-activated calcium-mobilizing (VACM-1) receptor appears to be ubiquitously expressed in various tissues of the laboratory rat, [RefSeq, PubMed]; VACM-1 mRNA and protein levels were significantly higher in rat mesenteric arteries, skeletal muscle and the heart ventricle but not in the heart atrium from 24-h water-deprived rats when compared to the controls., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0004842 ubiquitin-protein transferase activity;GO:0005000 vasopressin receptor activity;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0019005 SCF ubiquitin ligase complex;GO:0031466 Cul5-RING ubiquitin ligase complex;GO:0090734 site of DNA damage;GO:0031461 cullin-RING ubiquitin ligase complex", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0016477 cell migration;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JJ31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQH5-1", "uniprot_id": [ { "id": "CTBP2_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQH5", "type": "external" } ], "mass": 48987.0, "length": 445, "protein_name": "C-terminal-binding protein 2", "gene_name": "Ctbp2", "organism": "Rat", "refseq_name": "C-terminal-binding protein 2", "refseq_ac": [ { "id": "NP_445787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445787", "type": "external" } ], "gene_names_uniprotkb": "Ctbp2", "gene_names_refseq": "Ctbp2", "protein_names_uniprotkb": "C-terminal-binding protein 2; CtBP2", "protein_names_refseq": "C-terminal-binding protein 2", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (rno:81717); (R-RNO-4641265); (R-RNO-9764725)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11163272;22673903;25447313;31518606;35969153", "class_list": "", "function": "Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Isoform 2 probably acts as a scaffold for specialized synapses (By similarity)., [UniProtKB]; Esults indicated that Brn4 promoted the neuronal differentiation of neural stem cells via inhibition of CtBP2 and is a potential tool for generating neurons in cell replacement therapy of neurodegenerative diseases and brain injury, [RefSeq, PubMed]; Microenvironmental oxygen levels influence the dimerization and acetylation levels, and thereby the activity, of CtBP2 in proliferating neural stem cells., [RefSeq, PubMed]; The dorsal hippocampal CA3 regulates spatial reference memory through the CtBP2/GluR2 pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005634 nucleus;GO:0045202 synapse", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050872 white fat cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EQH5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU82-1", "uniprot_id": [ { "id": "CTNB1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WU82", "type": "external" } ], "mass": 85455.0, "length": 781, "protein_name": "Catenin beta-1", "gene_name": "Ctnnb1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ctnnb1; Catnb", "gene_names_refseq": "", "protein_names_uniprotkb": "Catenin beta-1; Beta-catenin", "protein_names_refseq": "", "tax_id": 10116, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); medulloblastoma (Disease Ontology:DOID:0050902); stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 19 (Disease Ontology:DOID:0070049); exudative vitreoretinopathy 7 (Disease Ontology:DOID:0080264); traumatic brain injury (Disease Ontology:DOID:0081292); progressive osseous heteroplasia (Disease Ontology:DOID:0111535); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); calcinosis (Disease Ontology:DOID:182); endodermal sinus tumor (Disease Ontology:DOID:1911); hepatitis B (Disease Ontology:DOID:2043); nephroblastoma (Disease Ontology:DOID:2154); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); granulosa cell tumor (Disease Ontology:DOID:2999); carcinoma (Disease Ontology:DOID:305); teratoma (Disease Ontology:DOID:3307); invasive lobular carcinoma (Disease Ontology:DOID:3457); lung carcinoma (Disease Ontology:DOID:3905); lung squamous cell carcinoma (Disease Ontology:DOID:3907); papillary thyroid carcinoma (Disease Ontology:DOID:3969); renal cell carcinoma (Disease Ontology:DOID:4450); fibrolamellar carcinoma (Disease Ontology:DOID:5015); pilomatrixoma (Disease Ontology:DOID:5374); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); neuropathy (Disease Ontology:DOID:870); in situ carcinoma (Disease Ontology:DOID:8719); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:84353); (R-RNO-195253); (R-RNO-196299); (R-RNO-201681); (R-RNO-201722); (R-RNO-3134973); (R-RNO-351906); (R-RNO-3769402); (R-RNO-4086398); (R-RNO-418990); (R-RNO-4641262); (R-RNO-5218920); (R-RNO-525793); (R-RNO-5626467); (R-RNO-8951430); (R-RNO-9762292); (R-RNO-9764561); (R-RNO-9766229); (R-RNO-9768727); (R-RNO-9825892); (R-RNO-9943962); (R-RNO-9958810); (R-RNO-9958825)", "pathway_count": 23, "publication_count": 25, "publication_id_list": "10497305;10921920;11867232;12640114;16237183;16641100;16682528;16815997;17639448;22540008;22673903;23198873;23754802;26739494;26964897;27558955;28220106;29193729;29230196;29299199;29752762;30409165;32390823;38843836;39704274", "class_list": "", "function": "Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Also acts as a coactivator for other transcription factors, such as NR5A2 (By similarity). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (By similarity). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 39, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0090279 regulation of calcium ion import;GO:0030316 osteoclast differentiation;GO:0030997 regulation of centriole-centriole cohesion;GO:1904888 cranial skeletal system development", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "Q9WU82-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1E1-1", "uniprot_id": [ { "id": "FLOT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1E1", "type": "external" } ], "mass": 47499.0, "length": 428, "protein_name": "Flotillin-1", "gene_name": "Flot1", "organism": "Rat", "refseq_name": "flotillin-1", "refseq_ac": [ { "id": "NP_073192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073192", "type": "external" } ], "gene_names_uniprotkb": "Flot1; Reg2", "gene_names_refseq": "Flot1; Rareg", "protein_names_uniprotkb": "Flotillin-1; REG-2; Reggie-2", "protein_names_refseq": "REG-2; flotillin-1; reggie-2", "tax_id": 10116, "disease": "", "pathway": " (rno:64665); (R-RNO-5213460); (R-RNO-5675482); (R-RNO-8849932); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "25732136;27676653;30452906;38843836;9858255", "class_list": "", "function": "Data suggest that flotillin-1 and flotillin-2 function as thyroglobulin-binding proteins in lipid rafts of thyrocytes; these interactions appear to exert negative-feedback effects on gene expression in thyrocytes., [RefSeq, PubMed]; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles., [UniProtKB]; Study illustrates early developmental changes in the cellular and subcellular localization of flotillin-1 in the rat visual cortex and suggests that flotillin-1 was transported mainly into presynaptic terminals, [RefSeq, PubMed]; The presence of Flotillin-1, in addition to Flotillin-2 in the cardiac intercalated disc, is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z1E2", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0022617 extracellular matrix disassembly;GO:0035556 intracellular signal transduction;GO:0072659 protein localization to plasma membrane;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z1E1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYV8-1", "uniprot_id": [ { "id": "DPOG1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYV8", "type": "external" } ], "mass": 136856.0, "length": 1216, "protein_name": "DNA polymerase subunit gamma-1", "gene_name": "Polg", "organism": "Rat", "refseq_name": "DNA polymerase subunit gamma-1", "refseq_ac": [ { "id": "NP_445980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445980", "type": "external" } ], "gene_names_uniprotkb": "Polg; Mip1; Polg1", "gene_names_refseq": "Polg", "protein_names_uniprotkb": "DNA polymerase subunit gamma-1; 2.7.7.7; 3'-5' exodeoxyribonuclease; 3.1.11.-; 4.2.99.-; 5'-deoxyribose-phosphate lyase; Mitochondrial DNA polymerase catalytic subunit; PolG-alpha", "protein_names_refseq": "3'-5' exodeoxyribonuclease; 5'-deoxyribose-phosphate lyase; DNA polymerase subunit gamma-1; DNA-directed DNA polymerase gamma; mitochondrial DNA polymerase catalytic subunit; polG-alpha; polymerase (DNA directed), gamma; polymerase (DNA) gamma, catalytic subunit", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); cerebellar ataxia (Disease Ontology:DOID:0050753); myelodysplastic syndrome (Disease Ontology:DOID:0050908); Alpers-Huttenlocher syndrome (Disease Ontology:DOID:0080122); mitochondrial DNA depletion syndrome 4b (Disease Ontology:DOID:0080123); sensory ataxic neuropathy, dysarthria, and ophthalmoparesis (Disease Ontology:DOID:0111276); autosomal dominant progressive external ophthalmoplegia 1 (Disease Ontology:DOID:0111521); autosomal recessive progressive external ophthalmoplegia 1 (Disease Ontology:DOID:0111522); premature menopause (Disease Ontology:DOID:10787); chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); multiple sclerosis (Disease Ontology:DOID:2377); bipolar disorder (Disease Ontology:DOID:3312); mood disorder (Disease Ontology:DOID:3324); progeria (Disease Ontology:DOID:3911); primary ovarian insufficiency (Disease Ontology:DOID:5426); peripheral nervous system disease (Disease Ontology:DOID:574); hepatocellular carcinoma (Disease Ontology:DOID:684); mitochondrial metabolism disease (Disease Ontology:DOID:700); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (rno:85472); (R-RNO-9913635)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Catalytic subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Replicates both heavy and light strands of the circular mtDNA genome using a single-stranded DNA template, RNA primers and the four deoxyribonucleoside triphosphates as substrates (By similarity). Has 5' -> 3' polymerase activity. Functionally interacts with TWNK and SSBP1 at the replication fork to form a highly processive replisome, where TWNK unwinds the double-stranded DNA template prior to replication and SSBP1 covers the parental heavy strand to enable continuous replication of the entire mitochondrial genome. A single nucleotide incorporation cycle includes binding of the incoming nucleotide at the insertion site, a phosphodiester bond formation reaction that extends the 3'-end of the primer DNA, and translocation of the primer terminus to the post-insertion site. After completing replication of a mtDNA strand, mediates 3' -> 5' exonucleolytic degradation at the nick to enable proper ligation (By similarity). Highly accurate due to high nucleotide selectivity and 3' -> 5' exonucleolytic proofreading. Proficiently corrects base substitutions, single-base additions and deletions in non-repetitive sequences and short repeats, but displays lower proofreading activity when replicating longer homopolymeric stretches. Exerts exonuclease activity toward single-stranded DNA and double-stranded DNA containing 3'-terminal mispairs. When a misincorporation occurs, transitions from replication to a pro-nucleolytic editing mode and removes the missincorporated nucleoside in the exonuclease active site. Proceeds via an SN2 nucleolytic mechanism in which Asp-198 catalyzes phosphodiester bond hydrolysis and Glu-200 stabilizes the leaving group. As a result the primer strand becomes one nucleotide shorter and is positioned in the post-insertion site, ready to resume DNA synthesis (By similarity). Exerts 5'-deoxyribose phosphate (dRP) lyase activity and mediates repair-associated mtDNA synthesis (gap filling) in base-excision repair pathway. Catalyzes the release of the 5'-terminal 2-deoxyribose-5-phosphate sugar moiety from incised apurinic/apyrimidinic (AP) sites to produce a substrate for DNA ligase. The dRP lyase reaction does not require divalent metal ions and likely proceeds via a Schiff base intermediate in a beta-elimination reaction mechanism (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYV7", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0002020 protease binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0043195 terminal bouton;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006287 base-excision repair, gap-filling;GO:0045004 DNA replication proofreading;GO:0010332 response to gamma radiation;GO:0071333 cellular response to glucose stimulus;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QYV8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ09-1", "uniprot_id": [ { "id": "NPT2B_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJ09", "type": "external" } ], "mass": 75992.0, "length": 695, "protein_name": "Sodium-dependent phosphate transport protein 2B", "gene_name": "Slc34a2", "organism": "Rat", "refseq_name": "sodium-dependent phosphate transport protein 2B", "refseq_ac": [ { "id": "NP_445832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445832", "type": "external" } ], "gene_names_uniprotkb": "Slc34a2", "gene_names_refseq": "Slc34a2", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; NaPi-2b; Sodium-phosphate transport protein 2B; Sodium/phosphate cotransporter 2B; Solute carrier family 34 member 2; rNaPi IIb", "protein_names_refseq": "Na(+)-dependent phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; naPi-2b; rNaPi IIb; sodium-dependent phosphate transport protein 2B; sodium-phosphate transport protein 2B; sodium/phosphate cotransporter 2B; solute carrier family 34 (sodium phosphate), member 2; solute carrier family 34 (type II sodium/phosphate contransporter), member 2; solute carrier family 34 (type II sodium/phosphate cotransporter), member 2; type IIb sodium-phosphate transporter", "tax_id": 10116, "disease": "pulmonary alveolar microlithiasis (Disease Ontology:DOID:12117)", "pathway": " (rno:84395); (R-RNO-427589); (R-RNO-5683826)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10880371;12893629;22235299;22673903;22904329;28179233;33846411", "class_list": "", "function": "Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal mortality. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in actively transporting phosphate into cells via Na(+) cotransport., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; NaPi-IIb is upregulated in the kidney in response to the active excretion of phosphate in HP diet-fed rats, [RefSeq, PubMed]; That NHERF1 associates with NaPi-2b in enterocytes and regulates NaPi-2b adaptation., [RefSeq, PubMed]; This is the first evidence of an active Si transport protein in mammals and points towards an important role for Si in vertebrates and explains interactions between dietary phosphate and silicon., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8VI55", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0019904 protein domain specific binding;GO:0031402 sodium ion binding;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016020 membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0032355 response to estradiol;GO:0043627 response to estrogen;GO:0006817 phosphate ion transport;GO:0009750 response to fructose", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JJ09-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN72-1", "uniprot_id": [ { "id": "MCRI1_RAT", "url": "https://www.uniprot.org/uniprot/B0BN72", "type": "external" } ], "mass": 11101.0, "length": 97, "protein_name": "Mapk-regulated corepressor-interacting protein 1", "gene_name": "Mcrip1", "organism": "Rat", "refseq_name": "mapk-regulated corepressor-interacting protein 1", "refseq_ac": [ { "id": "NP_001101781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101781", "type": "external" } ], "gene_names_uniprotkb": "Mcrip1; Fam195b", "gene_names_refseq": "Fam195b; Mcrip1; RGD1311925", "protein_names_uniprotkb": "Mapk-regulated corepressor-interacting protein 1; Protein FAM195B", "protein_names_refseq": "family with sequence similarity 195, member B; mapk-regulated corepressor-interacting protein 1; protein FAM195B", "tax_id": 10116, "disease": "", "pathway": " (rno:360677)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0045814 negative regulation of gene expression, epigenetic;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0BN72-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIA3-1", "uniprot_id": [ { "id": "IKBB_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIA3", "type": "external" } ], "mass": 38081.0, "length": 359, "protein_name": "NF-kappa-B inhibitor beta", "gene_name": "Nfkbib", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nfkbib; Ikbb", "gene_names_refseq": "", "protein_names_uniprotkb": "NF-kappa-B inhibitor beta; I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; NF-kappa-BIB", "protein_names_refseq": "", "tax_id": 10116, "disease": "collagen disease (Disease Ontology:DOID:854)", "pathway": " (R-RNO-1169091); (R-RNO-1810476); (R-RNO-445989); (R-RNO-933542)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10827092;16822942", "class_list": "", "function": "Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0071222 cellular response to lipopolysaccharide;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JIA3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZH12-1", "uniprot_id": [ { "id": "D3ZH12_RAT", "url": "https://www.uniprot.org/uniprot/D3ZH12", "type": "external" } ], "mass": 33257.0, "length": 301, "protein_name": "Nitric oxide synthase-interacting protein", "gene_name": "Nosip", "organism": "Rat", "refseq_name": "nitric oxide synthase-interacting protein", "refseq_ac": [ { "id": "NP_001424388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001424388", "type": "external" } ], "gene_names_uniprotkb": "Nosip", "gene_names_refseq": "Nosip", "protein_names_uniprotkb": "Nitric oxide synthase-interacting protein", "protein_names_refseq": "nitric oxide synthase-interacting protein", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (rno:292894); (R-RNO-203754)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23135205", "class_list": "", "function": "Data suggested that NOSIP may play an important roles in astrogliogenesis after a spinal cord injury., [RefSeq, PubMed]; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0043086 negative regulation of catalytic activity;GO:0051001 negative regulation of nitric-oxide synthase activity;GO:0045428 regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZH12-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AB50-1", "uniprot_id": [ { "id": "D4AB50_RAT", "url": "https://www.uniprot.org/uniprot/D4AB50", "type": "external" } ], "mass": 89441.0, "length": 786, "protein_name": "Rho GTPase-activating protein 10", "gene_name": "Arhgap10", "organism": "Rat", "refseq_name": "rho GTPase-activating protein 10", "refseq_ac": [ { "id": "NP_001102971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102971", "type": "external" } ], "gene_names_uniprotkb": "Arhgap10", "gene_names_refseq": "Arhgap10", "protein_names_uniprotkb": "Rho GTPase-activating protein 10; Rho-type GTPase-activating protein 10", "protein_names_refseq": "rho GTPase-activating protein 10", "tax_id": 10116, "disease": "Billuart-type X-linked syndromic intellectual developmental disorder (Disease Ontology:DOID:0080311)", "pathway": " (rno:688429); (R-RNO-8980692); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes. Also converts Cdc42 to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0010008 endosome membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AB50-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYI5-1", "uniprot_id": [ { "id": "B2RYI5_RAT", "url": "https://www.uniprot.org/uniprot/B2RYI5", "type": "external" } ], "mass": 40490.0, "length": 363, "protein_name": "Ankyrin repeat domain 40", "gene_name": "Ankrd40", "organism": "Rat", "refseq_name": "ankyrin repeat domain-containing protein 40", "refseq_ac": [ { "id": "NP_001128171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128171", "type": "external" } ], "gene_names_uniprotkb": "Ankrd40", "gene_names_refseq": "Ankrd40", "protein_names_uniprotkb": "Ankyrin repeat domain 40", "protein_names_refseq": "ankyrin repeat domain-containing protein 40", "tax_id": 10116, "disease": "", "pathway": " (rno:690586)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E9PTM3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYI5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2QC54-1", "uniprot_id": [ { "id": "A0A0G2QC54_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2QC54", "type": "external" } ], "mass": 28445.0, "length": 263, "protein_name": "TPD52 like 3", "gene_name": "Tpd52l3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tpd52l3", "gene_names_refseq": "", "protein_names_uniprotkb": "TPD52 like 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2QC54-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFF9-1", "uniprot_id": [ { "id": "B5DFF9_RAT", "url": "https://www.uniprot.org/uniprot/B5DFF9", "type": "external" } ], "mass": 55512.0, "length": 507, "protein_name": "E3 SUMO-protein ligase PIAS4", "gene_name": "Pias4", "organism": "Rat", "refseq_name": "E3 SUMO-protein ligase PIAS4", "refseq_ac": [ { "id": "NP_001094227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094227", "type": "external" } ], "gene_names_uniprotkb": "Pias4", "gene_names_refseq": "Pias4", "protein_names_uniprotkb": "E3 SUMO-protein ligase PIAS4; 2.3.2.27; PIASy; Protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma", "protein_names_refseq": "E3 SUMO-protein ligase PIAS4", "tax_id": 10116, "disease": "hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (rno:362827); (R-RNO-196791); (R-RNO-3108214); (R-RNO-3232118); (R-RNO-3232142); (R-RNO-3899300); (R-RNO-4085377); (R-RNO-4090294); (R-RNO-4615885); (R-RNO-4755510); (R-RNO-5693565); (R-RNO-5693571); (R-RNO-5693607); (R-RNO-69473)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "21454665;37014755", "class_list": "", "function": "Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; The increase of NCOA3 is essential for SYT-SSX1-mediated synovial sarcoma formation. SYT-SSX1 does so by increasing the sumoylation of NCOA3 through interaction with a SUMO E3 ligase, PIASy, as well as the sumoylation of NEMO., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "5.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016740 transferase activity;GO:0061665 SUMO ligase activity;GO:0003677 DNA binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0016604 nuclear body;GO:1990234 transferase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0016925 protein sumoylation;GO:0060255 regulation of macromolecule metabolic process;GO:1902174 positive regulation of keratinocyte apoptotic process;GO:0060887 limb epidermis development;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B5DFF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91ZN7-1", "uniprot_id": [ { "id": "CHK1_RAT", "url": "https://www.uniprot.org/uniprot/Q91ZN7", "type": "external" } ], "mass": 54428.0, "length": 476, "protein_name": "Serine/threonine-protein kinase Chk1", "gene_name": "Chek1; Stt3a", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase Chk1", "refseq_ac": [ { "id": "NP_536325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536325", "type": "external" } ], "gene_names_uniprotkb": "Chek1; Stt3a; Chek1; Chk1", "gene_names_refseq": "Chek1", "protein_names_uniprotkb": "Serine/threonine-protein kinase Chk1; 2.7.11.1; CHK1 checkpoint homolog; Checkpoint kinase-1", "protein_names_refseq": "CHK1 checkpoint homolog; checkpoint kinase 1 homolog; serine/threonine-protein kinase Chk1", "tax_id": 10116, "disease": "congenital disorder of glycosylation Iw (Disease Ontology:DOID:0080572); pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (rno:140583); (R-RNO-1433557); (R-RNO-176187); (R-RNO-5693607); (R-RNO-5693616); (R-RNO-6804756); (R-RNO-69473); (R-RNO-69601); (R-RNO-8953750)", "pathway_count": 9, "publication_count": 5, "publication_id_list": "11687578;23861943;24090084;24158981;25880015", "class_list": "", "function": "Casein kinase 1 delta activity is modulated by Chk1-mediated phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]; Chaperone-mediated autophagy, in response to genotoxic stress, is regulated by degradation of activated Chk1. Publication Status: Online-Only, [RefSeq, PubMed]; KIM-1 expression increased significantly in a manner that corresponded temporally and regionally with increased phosphorylation of checkpoint kinase 1 (Chk1) and STAT3 in acute kidney injury., [RefSeq, PubMed]; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA (By similarity). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest. Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (By similarity). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZN6", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0035402 histone H3T11 kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0046602 regulation of mitotic centrosome separation;GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006468 protein phosphorylation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q91ZN7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZE91-1", "uniprot_id": [ { "id": "D3ZE91_RAT", "url": "https://www.uniprot.org/uniprot/D3ZE91", "type": "external" } ], "mass": 42503.0, "length": 389, "protein_name": "BTB/POZ domain-containing protein KCTD9", "gene_name": "Kctd9", "organism": "Rat", "refseq_name": "BTB/POZ domain-containing protein KCTD9", "refseq_ac": [ { "id": "NP_001102341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102341", "type": "external" } ], "gene_names_uniprotkb": "Kctd9", "gene_names_refseq": "Kctd9", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD9", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD9; potassium channel tetramerisation domain containing 9", "tax_id": 10116, "disease": "", "pathway": " (rno:364410)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0097602 cullin family protein binding", "go_cellular_component": "", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001779 natural killer cell differentiation;GO:0035556 intracellular signal transduction;GO:0009615 response to virus;GO:0048469 cell maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZE91-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEI6-1", "uniprot_id": [ { "id": "D3ZEI6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEI6", "type": "external" } ], "mass": 65317.0, "length": 578, "protein_name": "Nuclear receptor coactivator 5", "gene_name": "Ncoa5", "organism": "Rat", "refseq_name": "nuclear receptor coactivator 5 isoform 1", "refseq_ac": [ { "id": "NP_001100013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100013", "type": "external" } ], "gene_names_uniprotkb": "Ncoa5", "gene_names_refseq": "Ncoa5", "protein_names_uniprotkb": "Nuclear receptor coactivator 5; Coactivator independent of AF-2", "protein_names_refseq": "nuclear receptor coactivator 5 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:296372)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0015629 actin cytoskeleton;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0042593 glucose homeostasis;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZEI6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WC42-1", "uniprot_id": [ { "id": "B1WC42_RAT", "url": "https://www.uniprot.org/uniprot/B1WC42", "type": "external" } ], "mass": 52325.0, "length": 494, "protein_name": "Thyroid hormone receptor interactor 6", "gene_name": "Trip6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trip6", "gene_names_refseq": "", "protein_names_uniprotkb": "Thyroid hormone receptor interactor 6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:686323)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0019900 kinase binding;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005925 focal adhesion", "go_biological_process": "GO:0007165 signal transduction;GO:0030335 positive regulation of cell migration;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0043009 chordate embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WC42-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIZ5-1", "uniprot_id": [ { "id": "DMBT1_RAT", "url": "https://www.uniprot.org/uniprot/Q8CIZ5", "type": "external" } ], "mass": 155720.0, "length": 1418, "protein_name": "Scavenger receptor cysteine-rich domain-containing protein DMBT1", "gene_name": "Dmbt1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dmbt1", "gene_names_refseq": "", "protein_names_uniprotkb": "Scavenger receptor cysteine-rich domain-containing protein DMBT1; Deleted in malignant brain tumors 1 protein; Ebnerin; Hensin; Pancrin", "protein_names_refseq": "", "tax_id": 10116, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (rno:170568); (R-RNO-5683826)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11121438;12368192;29393594;7629065", "class_list": "", "function": "May play roles in mucosal defense system, cellular immune defense and epithelial differentiation (By similarity). May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophages tissues throughout the body, including epithelial cells lining the gastrointestinal tract (By similarity). Required for terminal differentiation of columnar epithelial cells during early embryogenesis. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell (By similarity)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 20, "predicted_n_glycosites": 15, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "Q62827;Q6QD54", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005044 scavenger receptor activity;GO:1904399 heparan sulfate binding;GO:0001530 lipopolysaccharide binding;GO:0035375 zymogen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0030658 transport vesicle membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0030858 positive regulation of epithelial cell differentiation;GO:0015031 protein transport;GO:0030154 cell differentiation;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CIZ5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEL9-1", "uniprot_id": [ { "id": "D3ZEL9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEL9", "type": "external" } ], "mass": 35953.0, "length": 317, "protein_name": "Olfactory receptor", "gene_name": "Or8b56g; Or8b56", "organism": "Rat", "refseq_name": "olfactory receptor Olr1266 isoform X1", "refseq_ac": [ { "id": "XP_063122017", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063122017", "type": "external" } ], "gene_names_uniprotkb": "Or8b56g; Or8b56; Olr1266; Or8b56g", "gene_names_refseq": "Olr1266; Or8b56g", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor Olr1266 isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZEL9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZE77-1", "uniprot_id": [ { "id": "D3ZE77_RAT", "url": "https://www.uniprot.org/uniprot/D3ZE77", "type": "external" } ], "mass": 64770.0, "length": 580, "protein_name": "MIER family member 3", "gene_name": "Mier3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mier3", "gene_names_refseq": "", "protein_names_uniprotkb": "MIER family member 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "breast cancer (Disease Ontology:DOID:1612); invasive ductal carcinoma (Disease Ontology:DOID:3008); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcriptional repressor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0032991 protein-containing complex;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZE77-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A0H4-1", "uniprot_id": [ { "id": "D4A0H4_RAT", "url": "https://www.uniprot.org/uniprot/D4A0H4", "type": "external" } ], "mass": 86969.0, "length": 745, "protein_name": "Cullin-2", "gene_name": "Cul2", "organism": "Rat", "refseq_name": "cullin-2", "refseq_ac": [ { "id": "NP_001386142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386142", "type": "external" } ], "gene_names_uniprotkb": "Cul2", "gene_names_refseq": "Cul2", "protein_names_uniprotkb": "Cullin-2", "protein_names_refseq": "cullin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:361258); (R-RNO-1234176); (R-RNO-8951664); (R-RNO-983168); (R-RNO-9954709)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0031461 cullin-RING ubiquitin ligase complex;GO:0030891 VCB complex;GO:0005730 nucleolus;GO:0031462 Cul2-RING ubiquitin ligase complex;GO:0005634 nucleus", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030163 protein catabolic process;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A0H4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZNV6-1", "uniprot_id": [ { "id": "D3ZNV6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZNV6", "type": "external" } ], "mass": 34783.0, "length": 293, "protein_name": "ELMO domain containing 2", "gene_name": "Elmod2", "organism": "Rat", "refseq_name": "ELMO domain-containing protein 2", "refseq_ac": [ { "id": "NP_001102976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102976", "type": "external" } ], "gene_names_uniprotkb": "Elmod2; LOC100910164; LOC120098139", "gene_names_refseq": "Elmod2; RGD1307344", "protein_names_uniprotkb": "ELMO domain containing 2", "protein_names_refseq": "ELMO domain-containing protein 2-like; ELMO domain-containing protein 2; ELMO/CED-12 domain containing 2", "tax_id": 10116, "disease": "", "pathway": " (rno:688581)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "", "go_biological_process": "GO:0050688 regulation of defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZNV6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHY8-1", "uniprot_id": [ { "id": "DNLI1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHY8", "type": "external" } ], "mass": 102482.0, "length": 918, "protein_name": "DNA ligase 1", "gene_name": "Lig1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lig1", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA ligase 1; 6.5.1.1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "immunodeficiency 96 (Disease Ontology:DOID:0061066); cancer (Disease Ontology:DOID:162); primary immunodeficiency disease (Disease Ontology:DOID:612); inherited metabolic disorder (Disease Ontology:DOID:655); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725)", "pathway": " (R-RNO-110362); (R-RNO-174414); (R-RNO-5358565); (R-RNO-5358606); (R-RNO-5651801); (R-RNO-5685938); (R-RNO-6782210); (R-RNO-69183)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "DNA ligase that seals nicks in double-stranded during DNA repair. Also involved in DNA replication and DNA recombination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0003909 DNA ligase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003910 DNA ligase (ATP) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006273 lagging strand elongation;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JHY8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2KBC9-1", "uniprot_id": [ { "id": "LRB3L_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2KBC9", "type": "external" } ], "mass": 84944.0, "length": 761, "protein_name": "Leukocyte immunoglobulin-like receptor subfamily B member 3-like", "gene_name": "Lilrb1; Lilrb3l; Pira2; Pirb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lilrb1; Lilrb3l; Pira2; Pirb; Lilrb1; Lilrb3l; Pir-A1; Pirb", "gene_names_refseq": "", "protein_names_uniprotkb": "Leukocyte immunoglobulin-like receptor subfamily B member 3-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:100912456); (rno:361493)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10586026", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A2JHX5;A2JHX6", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0001540 amyloid-beta binding;GO:0032396 inhibitory MHC class I receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0007611 learning or memory;GO:1900271 regulation of long-term synaptic potentiation;GO:0001782 B cell homeostasis;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2KBC9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ76-1", "uniprot_id": [ { "id": "FMO3_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQ76", "type": "external" } ], "mass": 59960.0, "length": 531, "protein_name": "Flavin-containing monooxygenase 3", "gene_name": "Fmo3", "organism": "Rat", "refseq_name": "flavin-containing monooxygenase 3", "refseq_ac": [ { "id": "NP_445885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445885", "type": "external" } ], "gene_names_uniprotkb": "Fmo3", "gene_names_refseq": "Fmo3", "protein_names_uniprotkb": "Flavin-containing monooxygenase 3; 1.14.13.148; 1.14.13.32; 1.14.13.8; Dimethylaniline monooxygenase [N-oxide-forming] 3; Dimethylaniline oxidase 3; FMO 3; Hepatic flavin-containing monooxygenase 3; Trimethylamine monooxygenase", "protein_names_refseq": "FMO 3; dimethylaniline monooxygenase [N-oxide-forming] 3; dimethylaniline oxidase 3; flavin containing monooxygenase 3; flavin-containing monooxygenase 3; hepatic flavin-containing monooxygenase 3; trimethylamine monooxygenase", "tax_id": 10116, "disease": "chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411); trimethylaminuria (Disease Ontology:DOID:0080361); hypertension (Disease Ontology:DOID:10763); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (rno:84493); (R-RNO-217271)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11414682;11996886;18775983;19307449;3739217;7736906", "class_list": "", "function": "Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes., [RefSeq, PubMed]; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Results demonstrate many similar properties between rat hepatic and renal FMO3 forms and suggest that renal FMO3 may play an important role in kidney metabolism of xenobiotics containing sulfur and selenium atoms., [RefSeq, PubMed]; The relationship between gender and development in the expression of FMO3 in the liver and kidney was determined, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PQV6", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.148", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.148", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.14.13.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.32", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0016597 amino acid binding;GO:0034899 trimethylamine monooxygenase activity;GO:0050661 NADP binding;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0042412 taurine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EQ76-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBU2-1", "uniprot_id": [ { "id": "NDRG2_RAT", "url": "https://www.uniprot.org/uniprot/Q8VBU2", "type": "external" } ], "mass": 40779.0, "length": 371, "protein_name": "Protein NDRG2", "gene_name": "Ndrg2", "organism": "Rat", "refseq_name": "protein NDRG2 isoform a", "refseq_ac": [ { "id": "NP_001257791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257791", "type": "external" } ], "gene_names_uniprotkb": "Ndrg2", "gene_names_refseq": "Ndrg2", "protein_names_uniprotkb": "Protein NDRG2; Antidepressant-related protein ADRG123; N-myc downstream-regulated gene 2 protein; NDRG1-related protein", "protein_names_refseq": "N-myc downstream regulated gene 2; N-myc downstream-regulated gene 2 protein; NDRG1-related protein; antidepressant-related protein ADRG123; protein NDRG2 isoform a; protein NDRG2", "tax_id": 10116, "disease": "", "pathway": " (rno:171114)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12072429;14985363;14993068;15769300;16039777;16396499;22673903;32329820;32688030;32990844;33583230;38411782", "class_list": "", "function": "Association between NDRG2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats., [RefSeq, PubMed]; Astrocytic NDRG2 is critical in the maintenance of neuropathic pain., [RefSeq, PubMed]; Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; MiR-130a/Ndrg2 Axis Inhibits the Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis., [RefSeq, PubMed]; N-myc downstream regulated gene 2 ameliorates myocardial remodeling and cardiac function in heart failure rats., [RefSeq, PubMed]; Results indicate that NDRG2 regulation by aldosterone is an early mineralocorticoid-specific effect, [RefSeq, PubMed]; Review concludes that the study of Ndrg2 regulation and function in glia could contribute to understanding the pathogenesis and treatment of depression. Review article, [RefSeq, PubMed]; Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VBW2;Q8VI00;Q8VI01", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030426 growth cone", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8VBU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2N4-1", "uniprot_id": [ { "id": "NXPH4_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2N4", "type": "external" } ], "mass": 32945.0, "length": 304, "protein_name": "Neurexophilin-4", "gene_name": "Nxph4", "organism": "Rat", "refseq_name": "neurexophilin-4 precursor", "refseq_ac": [ { "id": "NP_067712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067712", "type": "external" } ], "gene_names_uniprotkb": "Nxph4; Nph4", "gene_names_refseq": "Nph4; Nxph4", "protein_names_uniprotkb": "Neurexophilin-4", "protein_names_refseq": "neurexophilin-4 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:59316)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9570794", "class_list": "", "function": "May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors., [UniProtKB]; May be signaling molecules that resemble neuropeptides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q642D9", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005576 extracellular region;GO:0045202 synapse", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z2N4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK72-1", "uniprot_id": [ { "id": "CCS_RAT", "url": "https://www.uniprot.org/uniprot/Q9JK72", "type": "external" } ], "mass": 28890.0, "length": 274, "protein_name": "Copper chaperone for superoxide dismutase", "gene_name": "Ccs", "organism": "Rat", "refseq_name": "copper chaperone for superoxide dismutase", "refseq_ac": [ { "id": "NP_445877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445877", "type": "external" } ], "gene_names_uniprotkb": "Ccs", "gene_names_refseq": "Ccs", "protein_names_uniprotkb": "Copper chaperone for superoxide dismutase; Superoxide dismutase copper chaperone", "protein_names_refseq": "copper chaperone for superoxide dismutase; superoxide dismutase copper chaperone", "tax_id": 10116, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003); neurodegenerative disease (Disease Ontology:DOID:1289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:84485); (R-RNO-3299685)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10964676;12832419;15337829;15722349", "class_list": "", "function": "Associated with copper deficiency were higher levels of Ccs in erythrocytes., [RefSeq, PubMed]; Beta-site amyloid precursor (APP) cleaving enzyme BACE1 expression reduces the activity of superoxide dismutase (SOD1) in cells consistent with direct competition for available CCS, as overexpression of CCS restores SOD1 activity., [RefSeq, PubMed]; Copper modulates the degradation of this protein, which prioritizes the utilization of copper when it is scarce., [RefSeq, PubMed]; Delivers copper to copper zinc superoxide dismutase (SOD1)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0BMW1", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.14.12.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0005507 copper ion binding;GO:0016532 superoxide dismutase copper chaperone activity;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051353 positive regulation of oxidoreductase activity;GO:0019430 removal of superoxide radicals;GO:0006801 superoxide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JK72-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2S9-1", "uniprot_id": [ { "id": "FLOT2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2S9", "type": "external" } ], "mass": 47038.0, "length": 428, "protein_name": "Flotillin-2", "gene_name": "Flot2", "organism": "Rat", "refseq_name": "flotillin-2 isoform 2", "refseq_ac": [ { "id": "NP_001257729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257729", "type": "external" } ], "gene_names_uniprotkb": "Flot2; Reg1", "gene_names_refseq": "Flot2", "protein_names_uniprotkb": "Flotillin-2; REG-1; Reggie-1", "protein_names_refseq": "REG-1; flotillin-2 isoform 2; reggie-1; reggie1-1", "tax_id": 10116, "disease": "", "pathway": " (rno:83764); (R-RNO-5213460); (R-RNO-5675482); (R-RNO-8849932); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9696264); (R-RNO-9696273)", "pathway_count": 9, "publication_count": 4, "publication_id_list": "14599293;27676653;30452906;9858255", "class_list": "", "function": "Data suggest that flotillin-1 and flotillin-2 function as thyroglobulin-binding proteins in lipid rafts of thyrocytes; these interactions appear to exert negative-feedback effects on gene expression in thyrocytes., [RefSeq, PubMed]; May play a role in axon growth and regeneration. May be involved in epidermal cell adhesion and epidermal structure and function., [UniProtKB, PubMed]; Myristoylation and palmitoylation of flotillin-2 are necessary for raft membrane association., [RefSeq, PubMed]; The presence of Flotillin-1, in addition to Flotillin-2 in the cardiac intercalated disc, is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QX33;Q9Z2S8", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0044860 protein localization to plasma membrane raft;GO:1903905 positive regulation of establishment of T cell polarity;GO:0007155 cell adhesion;GO:0010629 negative regulation of gene expression;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z2S9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDA1-1", "uniprot_id": [ { "id": "CSTN2_RAT", "url": "https://www.uniprot.org/uniprot/Q8VDA1", "type": "external" } ], "mass": 107729.0, "length": 965, "protein_name": "Calsyntenin-2", "gene_name": "Clstn2", "organism": "Rat", "refseq_name": "calsyntenin-2 precursor", "refseq_ac": [ { "id": "NP_599204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599204", "type": "external" } ], "gene_names_uniprotkb": "Clstn2; Cs2; Cstn2", "gene_names_refseq": "Clstn2; Cs2; Cstn2", "protein_names_uniprotkb": "Calsyntenin-2", "protein_names_refseq": "alc-gamma; alcadein-gamma; calsyntenin-2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:171394)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12498782", "class_list": "", "function": "Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0009986 cell surface;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0008306 associative learning;GO:0007268 chemical synaptic transmission;GO:0051965 positive regulation of synapse assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050806 positive regulation of synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VDA1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5M4-1", "uniprot_id": [ { "id": "OPTN_RAT", "url": "https://www.uniprot.org/uniprot/Q8R5M4", "type": "external" } ], "mass": 67014.0, "length": 585, "protein_name": "Optineurin", "gene_name": "Optn", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Optn", "gene_names_refseq": "", "protein_names_uniprotkb": "Optineurin; FIP-2-like protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis type 12 (Disease Ontology:DOID:0060203); neuronal intranuclear inclusion disease (Disease Ontology:DOID:0081294); open-angle glaucoma (Disease Ontology:DOID:1067); primary open angle glaucoma (Disease Ontology:DOID:1070); Huntington's disease (Disease Ontology:DOID:12858); low tension glaucoma (Disease Ontology:DOID:13544); bladder neck obstruction (Disease Ontology:DOID:13948); Parkinson's disease (Disease Ontology:DOID:14330); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Paget's disease of bone (Disease Ontology:DOID:5408); proteinuria (Disease Ontology:DOID:576); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (rno:246294); (R-RNO-2565942); (R-RNO-5205685); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-8854214); (R-RNO-936964); (R-RNO-9824878)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May act by regulating membrane trafficking and cellular morphogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR); regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5PQX8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0003407 neural retina development;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R5M4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUL6-1", "uniprot_id": [ { "id": "NSF_RAT", "url": "https://www.uniprot.org/uniprot/Q9QUL6", "type": "external" } ], "mass": 82652.0, "length": 744, "protein_name": "Vesicle-fusing ATPase", "gene_name": "Nsf", "organism": "Rat", "refseq_name": "vesicle-fusing ATPase", "refseq_ac": [ { "id": "NP_068516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068516", "type": "external" } ], "gene_names_uniprotkb": "Nsf; Erg1", "gene_names_refseq": "Nsf", "protein_names_uniprotkb": "Vesicle-fusing ATPase; 3.6.4.6; N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; Vesicular-fusion protein NSF", "protein_names_refseq": "N-ethylmaleimide-sensitive factor; N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; vesicle-fusing ATPase; vesicular-fusion protein NSF", "tax_id": 10116, "disease": "oculocutaneous albinism (Disease Ontology:DOID:0050632); autism spectrum disorder (Disease Ontology:DOID:0060041); developmental and epileptic encephalopathy 96 (Disease Ontology:DOID:0070377); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); temporal lobe epilepsy (Disease Ontology:DOID:3328); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:60355); (R-RNO-204005); (R-RNO-416993); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811438); (R-RNO-6811440)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "11278345;16461345;18683930;20802490;22673903;26766634;26839712;31932584", "class_list": "", "function": "Once trans-SNARE complexes that form large, stable pores by Ca2+-synaptotagmin 1, they can only be closed by the action of the N-ethylmaleimide sensitive factor(NSF). Time-resolved measurements reveal that NSF-mediated pore closure occurs via a complex 'stuttering' mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicate that glucocorticoid hormones increase AMPA receptor mediated synaptic transmission and synaptic insertion of AMPA receptors via a mechanism that requires NSF/GluA2 interaction. This may contribute to the memory enhancing effects of glucocorticoid hormones., [RefSeq, PubMed]; We have found increased expression of NSF gene in basolateral amygdala and perirhinal cortex in groups of rats undergoing taste habituation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0006886 intracellular protein transport;GO:0051260 protein homooligomerization;GO:2000463 positive regulation of excitatory postsynaptic potential;GO:0043278 response to morphine", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9QUL6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERC5-1", "uniprot_id": [ { "id": "OTOF_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERC5", "type": "external" } ], "mass": 226339.0, "length": 1993, "protein_name": "Otoferlin", "gene_name": "Otof", "organism": "Rat", "refseq_name": "otoferlin isoform X5", "refseq_ac": [ { "id": "XP_006239895", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006239895", "type": "external" } ], "gene_names_uniprotkb": "Otof; Fer1l2", "gene_names_refseq": "Otof", "protein_names_uniprotkb": "Otoferlin; Fer-1-like protein 2", "protein_names_refseq": "otoferlin isoform X5", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 9 (Disease Ontology:DOID:0110535); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (rno:84573)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "17229086;18772196;21216247", "class_list": "", "function": "Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0035612 AP-2 adaptor complex binding;GO:0044877 protein-containing complex binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0016323 basolateral plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0010996 response to auditory stimulus;GO:0007605 sensory perception of sound;GO:0036465 synaptic vesicle recycling;GO:0016079 synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ERC5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHJ1-1", "uniprot_id": [ { "id": "PIGU_RAT", "url": "https://www.uniprot.org/uniprot/Q8CHJ1", "type": "external" } ], "mass": 49953.0, "length": 435, "protein_name": "GPI-anchor transamidase component PIGU", "gene_name": "Pigu", "organism": "Rat", "refseq_name": "GPI-anchor transamidase component PIGU", "refseq_ac": [ { "id": "NP_853668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853668", "type": "external" } ], "gene_names_uniprotkb": "Pigu; Cdc91l1", "gene_names_refseq": "Cdc91l1; LRRGT00059; Pigu; sakura", "protein_names_uniprotkb": "GPI-anchor transamidase component PIGU; Cell division cycle protein 91-like 1; GPI transamidase component PIG-U; Liver regeneration-related protein LRRGT00059; Phosphatidylinositol glycan anchor biosynthesis class U protein; Protein CDC91-like 1", "protein_names_refseq": "CDC91 cell division cycle 91-like 1; GPI transamidase component PIG-U; GPI-anchor transamidase component PIGU; cell division cycle protein 91-like 1; liver regeneration-related protein LRRGT00059; phosphatidylinositol glycan anchor biosynthesis class U protein; protein CDC91-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:353304); (R-RNO-162791)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12802054", "class_list": "", "function": "Component of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis (PubMed:12802054). Binds the lipid portion of GPI-anchor. May act as an organizer in the transmembrane layer to recruit other subunits, and thus is essential for assembly of the complex (By similarity)., [UniProtKB, PubMed, UniProtKB]; Plays an important role in the elongation step of protein synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034235 GPI anchor binding;GO:0003923 GPI-anchor transamidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042765 GPI-anchor transamidase complex;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein;GO:0180046 GPI anchored protein biosynthesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CHJ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUQ3-1", "uniprot_id": [ { "id": "OLIG1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WUQ3", "type": "external" } ], "mass": 27239.0, "length": 261, "protein_name": "Oligodendrocyte transcription factor 1", "gene_name": "Olig1", "organism": "Rat", "refseq_name": "oligodendrocyte transcription factor 1", "refseq_ac": [ { "id": "NP_068538", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068538", "type": "external" } ], "gene_names_uniprotkb": "Olig1", "gene_names_refseq": "Olg1; Olig1; oligo1", "protein_names_uniprotkb": "Oligodendrocyte transcription factor 1; Olg-1 bHLH protein; Oligo1", "protein_names_refseq": "Olg-1 bHLH protein; oligodendrocyte transcription factor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:60394)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10719888;17872503;23973956;30143582;31702031", "class_list": "", "function": "Olig1 and Olig2 expression are enhanced during antipsychotic drug induced differentiation of oligodendrocyte progenitor cells., [RefSeq, PubMed]; Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, activates oligodendrocyte precursor cells (OPCs) formation while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN) through transcriptional regulation of GSX2. Mechanistically, binds and silences multiple conserved enhancer elements of GSX2. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube., [UniProtKB, UniProtKB]; Overexpression of olig1 and olig2 inhibits astrocyte differentiation and promotes oligodendrocyte differentiation of adult oligodendrocyte precursor cells., [RefSeq, PubMed]; Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube., [UniProtKB, UniProtKB]; The data of the present study may help clinicians understand the expression pattern of Olig1 and its potential role in endogenous remyelination after ischemia, which may have implications for the treatment of diseases that lead to demyelination., [RefSeq, PubMed]; These data strongly suggest that bone marrow stromal cells (BMSCs) can promote the differentiation of Neural stem cells (NSCs) into oligodendrocytes through mediating Id2 and Olig1/2 expression by blocking the BMP/Smad signaling pathway Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the oligodendrocyte lineage gene family which encode basic helix-loop-helix transcription factors. Studies in mice show that it is coexpressed with Olig2 in neural progenitors, and has a role in the development and maturation of oligodendrocytes. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0014003 oligodendrocyte development;GO:0048663 neuron fate commitment;GO:0061564 axon development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WUQ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET32-1", "uniprot_id": [ { "id": "BGAT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ET32", "type": "external" } ], "mass": 40375.0, "length": 348, "protein_name": "Histo-blood group ABO system transferase 1", "gene_name": "Abo3; Abo", "organism": "Rat", "refseq_name": "histo-blood group ABO system transferase 1", "refseq_ac": [ { "id": "NP_075582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075582", "type": "external" } ], "gene_names_uniprotkb": "Abo3; Abo; Abo1; Gbgt1", "gene_names_refseq": "Abo3; Abol1; Abo", "protein_names_uniprotkb": "Histo-blood group ABO system transferase 1; 2.4.1.37; 2.4.1.40; A transferase; B transferase; Blood group A glycosyltransferase 1; Cis-AB transferase 1; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Histo-blood group A transferase; Histo-blood group B transferase; N-acetylgalactosaminyltransferase A blood group-like enzyme; NAGAT 1", "protein_names_refseq": "ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase); ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; ABO blood group (transferase B, alpha 1-3-galactosyltransferase); ABO blood group-like 1; B blood group galactosyltransferase; N-acetylgalactosaminyltransferase A blood group-like enzyme; NAGAT 1; a transferase; alpha 1-3-N-acetylgalactosaminyltransferase-like 1; b transferase; blood group A glycosyltransferase 1; cis-AB transferase 1; fucosylglycoprotein 3-alpha-galactosyltransferase; fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; glycoprotein-fucosylgalactoside alpha-galactosyltransferase; histo-blood group A transferase; histo-blood group ABO system transferase 1; histo-blood group B transferase; transferase B, alpha 1-3-galactosyltransferase)", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); graft-versus-host disease (Disease Ontology:DOID:0081267); hypertension (Disease Ontology:DOID:10763); leukemia (Disease Ontology:DOID:1240); pulmonary sarcoidosis (Disease Ontology:DOID:13406); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); echinococcosis (Disease Ontology:DOID:1496); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis (Disease Ontology:DOID:2237); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); gallbladder carcinoma (Disease Ontology:DOID:4948); pneumonia (Disease Ontology:DOID:552); hemolytic anemia (Disease Ontology:DOID:583); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:65270)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11842091;12180981;12237302;12799344", "class_list": "glycogene;glycosyltransferase", "function": "Data indicate that rats have at least two distinct Abo genes, one monomorphic gene encoding a B-specific enzyme and one or more genes in some cases encoding an A-specific enzyme, [RefSeq, PubMed]; Possesses strong A transferase activity and weak B transferase activity., [UniProtKB, PubMed]; The complete coding sequence of a BDIX rat gene homologous to the human ABO gene was determined. It had strong UDP-GalNAc:Fucalpha1,2GalalphaGalNAc transferase activity and a small UDP-Gal:Fucalpha1,2GalalphaGal transferase activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 8, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8CFC5;Q8CFC6;Q8R005;Q8R4Y3;Q8R552", "ec_number_list": [ { "id": "2.4.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.37", "type": "external" }, { "id": "2.4.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.40", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004380 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity;GO:0004381 fucosylgalactoside 3-alpha-galactosyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0031982 vesicle;GO:0032580 Golgi cisterna membrane;GO:0016020 membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 1051, "hit_score": 0.5, "record_id": "Q9ET32-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIJ5-1", "uniprot_id": [ { "id": "OGA_RAT", "url": "https://www.uniprot.org/uniprot/Q8VIJ5", "type": "external" } ], "mass": 102918.0, "length": 916, "protein_name": "Protein O-GlcNAcase", "gene_name": "Oga", "organism": "Rat", "refseq_name": "protein O-GlcNAcase", "refseq_ac": [ { "id": "NP_571979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571979", "type": "external" } ], "gene_names_uniprotkb": "Oga; Hexc; Mea5; Mgea5", "gene_names_refseq": "Mgea5; Ncoat; Oga", "protein_names_uniprotkb": "Protein O-GlcNAcase; 3.2.1.169; Beta-N-acetylhexosaminidase; Beta-hexosaminidase; Bifunctional protein NCOAT; Meningioma-expressed antigen 5; N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; OGA", "protein_names_refseq": "N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; beta-N-acetylhexosaminidase; beta-hexosaminidase; bifunctional protein NCOAT; meningioma expressed antigen 5 (hyaluronidase); meningioma-expressed antigen 5; nuclear cytoplasmic O-GlcNAcase and acetyltransferase; protein O-GlcNAcase-like; protein O-GlcNAcase", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:154968)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "12242036;15485860;16517082;17496889;19023128;19322778;20657584;22673903;22928023;25183011;25916824;8034696", "class_list": "glycogene;glycosylhydrolase", "function": "Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:8034696). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (By similarity). Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:8034696). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]; Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Lacks enzyme activity., [UniProtKB, PubMed]; NCOAT may be regulated to reduce the state of glycosylation of transcriptional activators while increasing the acetylation of histones to allow for the concerted activation of eukaryotic gene transcription, [RefSeq, PubMed]; Present results provide definitive evidence that O-GlcNAcase antagonizes posthypoxic cardiac myocyte survival, [RefSeq, PubMed]; Protein O-GlcNAcylation, OGT, and OGA in the rat brain at various ages from embryonic day 15 to the age of 2 years, [RefSeq, PubMed]; Streptozotocin inhibition of O-GlcNAcase induces an insulin secretory defect in isolated rat islet cells, and a growth hormone secretory defect, and impairment of intracellular secretory vesicle trafficking., [RefSeq, PubMed]; This work identifies the first target of miR-539 in the heart and the first miRNA that regulates OGA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.169", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.169", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004402 histone acetyltransferase activity;GO:0016231 beta-N-acetylglucosaminidase activity;GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity;GO:0015929 hexosaminidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0046060 dATP metabolic process;GO:0032024 positive regulation of insulin secretion;GO:0043065 positive regulation of apoptotic process;GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8VIJ5-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0100010000001.010.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CH84-1", "uniprot_id": [ { "id": "ELAV2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CH84", "type": "external" } ], "mass": 39506.0, "length": 359, "protein_name": "ELAV-like protein 2", "gene_name": "Elavl2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Elavl2; Hub", "gene_names_refseq": "", "protein_names_uniprotkb": "ELAV-like protein 2; Hu-antigen B; HuB", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:286973)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0140517 protein-RNA adaptor activity", "go_cellular_component": "GO:0045202 synapse;GO:1990904 ribonucleoprotein complex;GO:0150048 cerebellar granule cell to Purkinje cell synapse", "go_biological_process": "GO:1990830 cellular response to leukemia inhibitory factor;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CH84-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIH8-1", "uniprot_id": [ { "id": "CSTD1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VIH8", "type": "external" } ], "mass": 14981.0, "length": 130, "protein_name": "Cystatin domain-containing protein 1", "gene_name": "Cstdc1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cstdc1; Cst14; LOC257643", "gene_names_refseq": "", "protein_names_uniprotkb": "Cystatin domain-containing protein 1; Cystatin SC; Cystatin-14", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:257643)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12444065", "class_list": "", "function": "May play a specialized role in spermatogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VIH8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z330-1", "uniprot_id": [ { "id": "DNMT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z330", "type": "external" } ], "mass": 182774.0, "length": 1622, "protein_name": "DNA (cytosine-5)-methyltransferase 1", "gene_name": "Dnmt1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dnmt1", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 1; 2.1.1.37; DNA MTase RnoIP; DNA methyltransferase I; Dnmt1; M.RnoIP; MCMT", "protein_names_refseq": "", "tax_id": 10116, "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); autosomal dominant cerebellar ataxia, deafness and narcolepsy (Disease Ontology:DOID:0050968); hereditary sensory neuropathy type 1E (Disease Ontology:DOID:0070158); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Graves' disease (Disease Ontology:DOID:12361); lung cancer (Disease Ontology:DOID:1324); congenital heart disease (Disease Ontology:DOID:1682); endometriosis of uterus (Disease Ontology:DOID:288); endometriosis (Disease Ontology:DOID:289); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); mucoepidermoid carcinoma (Disease Ontology:DOID:4531); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); choline deficiency disease (Disease Ontology:DOID:8456); chronic myeloid leukemia (Disease Ontology:DOID:8552); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); alopecia areata (Disease Ontology:DOID:986)", "pathway": " (rno:84350); (R-RNO-212300); (R-RNO-4655427)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "22673903;29393594;8667030;9722504;9878564", "class_list": "", "function": "DNA methyltransferase that methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70487;Q9R252;Q9WTX3;Q9WU57", "ec_number_list": [ { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005657 replication fork;GO:0032991 protein-containing complex;GO:0000792 heterochromatin", "go_biological_process": "GO:0043045 epigenetic programming of gene expression;GO:0097305 response to alcohol;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010288 response to lead ion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z330-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VDA6-1", "uniprot_id": [ { "id": "AVPI1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VDA6", "type": "external" } ], "mass": 16412.0, "length": 146, "protein_name": "Arginine vasopressin-induced protein 1", "gene_name": "Avpi1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Avpi1; Esau", "gene_names_refseq": "", "protein_names_uniprotkb": "Arginine vasopressin-induced protein 1; AVP-induced protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VDA6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZT0-1", "uniprot_id": [ { "id": "CUZD1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZT0", "type": "external" } ], "mass": 68640.0, "length": 607, "protein_name": "CUB and zona pellucida-like domain-containing protein 1", "gene_name": "Cuzd1", "organism": "Rat", "refseq_name": "CUB and zona pellucida-like domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_446457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446457", "type": "external" } ], "gene_names_uniprotkb": "Cuzd1; Erg1", "gene_names_refseq": "Cuzd1; ERG1; Itmap1; UO-44; Uo; Utczp", "protein_names_uniprotkb": "CUB and zona pellucida-like domain-containing protein 1; CUB and ZP domain-containing protein 1; Estrogen-regulated protein 1; Uterus/ovary-specific protein 44", "protein_names_refseq": "CUB and ZP domain-containing protein 1; CUB and zona pellucida-like domain-containing protein 1 precursor; CUB and zona pellucida-like domain-containing protein 1; estrogen-regulated gene 1; estrogen-regulated protein 1; integral membrane-associated protein 1; uterine-ovarian-specific gene 44; uterus/ovary-specific protein 44", "tax_id": 10116, "disease": "", "pathway": " (rno:117179)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10542259;11416020;23499927", "class_list": "", "function": "Localized to zymogen granules, where it functions in trypsinogen activation (By similarity). May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Localized to zymogen granules, where it functions in trypsinogen activation. May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions., [UniProtKB, UniProtKB]; The arrhythmogenic effect of a crude extract from sea anemone Condylactis gigantea possibly involves rErg1 channels., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O35360;Q5D000", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0016020 membrane;GO:0042589 zymogen granule membrane", "go_biological_process": "GO:0007565 female pregnancy;GO:0009755 hormone-mediated signaling pathway;GO:0032023 trypsinogen activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QZT0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHZ8-1", "uniprot_id": [ { "id": "DSCAM_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHZ8", "type": "external" } ], "mass": 222254.0, "length": 2013, "protein_name": "Cell adhesion molecule DSCAM", "gene_name": "Dscam", "organism": "Rat", "refseq_name": "cell adhesion molecule DSCAM precursor", "refseq_ac": [ { "id": "NP_598271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598271", "type": "external" } ], "gene_names_uniprotkb": "Dscam", "gene_names_refseq": "Dscam", "protein_names_uniprotkb": "Cell adhesion molecule DSCAM; Down syndrome cell adhesion molecule homolog", "protein_names_refseq": "Down syndrome cell adhesion molecule homolog; cell adhesion molecule DSCAM precursor; cell adhesion molecule DSCAM", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (rno:171119); (R-RNO-376172)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "18585357;19558816;21360594", "class_list": "", "function": "Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (By similarity). Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC (PubMed:18585357). Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity). In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (By similarity). Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; DSCAM may play an important role in mesenchymal stem cells (MSCs) differentiation into neural cells., [RefSeq, PubMed]; Dscam is highly expressed in rat brain during the different phases of experimental epilepsy., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity;GO:1990782 protein tyrosine kinase binding;GO:1990890 netrin receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0007626 locomotory behavior;GO:0035249 synaptic transmission, glutamatergic;GO:0007417 central nervous system development;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VHZ8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYM0-1", "uniprot_id": [ { "id": "MRP5_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYM0", "type": "external" } ], "mass": 160514.0, "length": 1436, "protein_name": "ATP-binding cassette sub-family C member 5", "gene_name": "Abcc5", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family C member 5 isoform 1", "refseq_ac": [ { "id": "NP_446376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446376", "type": "external" } ], "gene_names_uniprotkb": "Abcc5; Mrp5", "gene_names_refseq": "Abcc5a; Abcc5; Mrp5", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 5; 7.6.2.-; 7.6.2.2; Multidrug resistance-associated protein 5", "protein_names_refseq": "ATP-binding cassette sub-family C (CFTR/MRP) member 5a; ATP-binding cassette sub-family C member 5 isoform 1; ATP-binding cassette sub-family C member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette, subfamily C (CFTR/MRP), member 5; multidrug resistance-associated protein 5", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (rno:116721); (R-RNO-2142845); (R-RNO-382556); (R-RNO-9748787); (R-RNO-9753281)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "14715514;22015764;26244301", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (By similarity). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Important role for MRP5-mediated cGMP efflux in the regulation of NO-induced cerebral arteriolar relaxation, [RefSeq, PubMed]; In olfactory epithelium, high levels of expression of xenobiotic transporters Mrp1, Mrp3, Mrp5, Mdr1a, Oatp2 and Oat6 are expressed., [RefSeq, PubMed]; Multidrug resistance-associated proteins 1, 4, 5, and Oatp1a4 were present at the transcript level, but only Mrp1, 4, and 5 were detected at the protein level., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K6R4", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0015232 heme transmembrane transporter activity", "go_cellular_component": "GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0055085 transmembrane transport;GO:0032868 response to insulin;GO:0015865 purine nucleotide transport;GO:0098838 folate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QYM0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QY10-1", "uniprot_id": [ { "id": "FGFP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QY10", "type": "external" } ], "mass": 26887.0, "length": 238, "protein_name": "Fibroblast growth factor-binding protein 1", "gene_name": "Fgfbp1", "organism": "Rat", "refseq_name": "fibroblast growth factor-binding protein 1 precursor", "refseq_ac": [ { "id": "NP_072125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072125", "type": "external" } ], "gene_names_uniprotkb": "Fgfbp1", "gene_names_refseq": "Fgfbp1", "protein_names_uniprotkb": "Fibroblast growth factor-binding protein 1; FGF-BP1; FGF-BP; FGF-binding protein 1; FGFBP-1; Growth factor-binding protein 1", "protein_names_refseq": "FGF-BP1; FGF-BP; FGF-binding protein 1; FGFBP-1; fibroblast growth factor-binding protein 1 precursor; growth factor-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:64535); (R-RNO-190377)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10831072;17553847", "class_list": "", "function": "Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth (By similarity)., [UniProtKB]; FGF-BP is an early response gene after spinal cord injury and that its upregulation in regenerating spinal cord tissue may provide a molecular mechanism for enhancing the initial FGF2-mediated neurotrophic effects occurring after such tissue damage, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019838 growth factor binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis;GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway;GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QY10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4B7-1", "uniprot_id": [ { "id": "FMO4_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4B7", "type": "external" } ], "mass": 63660.0, "length": 560, "protein_name": "Dimethylaniline monooxygenase [N-oxide-forming] 4", "gene_name": "Fmo4", "organism": "Rat", "refseq_name": "dimethylaniline monooxygenase [N-oxide-forming] 4 long isoform", "refseq_ac": [ { "id": "NP_653147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653147", "type": "external" } ], "gene_names_uniprotkb": "Fmo4", "gene_names_refseq": "Fmo4", "protein_names_uniprotkb": "Dimethylaniline monooxygenase [N-oxide-forming] 4; 1.14.13.8; Dimethylaniline oxidase 4; FMO 4; Hepatic flavin-containing monooxygenase 4", "protein_names_refseq": "FMO 4; dimethylaniline monooxygenase [N-oxide-forming] 4 long isoform; dimethylaniline monooxygenase [N-oxide-forming] 4; dimethylaniline oxidase 4; flavin containing monooxygenase 4; hepatic flavin-containing monooxygenase 4", "tax_id": 10116, "disease": "chromosome 1q21.1 deletion syndrome (Disease Ontology:DOID:0060411)", "pathway": " (rno:246247)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12488558;19307449", "class_list": "", "function": "Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine., [UniProtKB, UniProtKB, UniProtKB]; By Western blotting using the two different forms of FMO4 antibodies, a long FMO4 protein was detected in the rat kidney, whereas in the rat brain, only the short form of FMO4 was observed., [RefSeq, PubMed]; Data show a compelling visual demonstration of the isoform-specific localization patterns of FMO1, -3, and -4 in the rat liver and kidney and the first evidence for expression of FMO4 at the protein level in mouse and human liver and kidney microsomes., [RefSeq, PubMed]; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66HR6", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.148", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.148", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.14.13.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.32", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0050661 NADP binding;GO:0004497 monooxygenase activity;GO:0004499 N,N-dimethylaniline monooxygenase activity;GO:0034899 trimethylamine monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046322 negative regulation of fatty acid oxidation;GO:0097009 energy homeostasis;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K4B7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2G8-1", "uniprot_id": [ { "id": "NP1L1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2G8", "type": "external" } ], "mass": 45314.0, "length": 390, "protein_name": "Nucleosome assembly protein 1-like 1", "gene_name": "Nap1l1", "organism": "Rat", "refseq_name": "nucleosome assembly protein 1-like 1", "refseq_ac": [ { "id": "NP_446013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446013", "type": "external" } ], "gene_names_uniprotkb": "Nap1l1; Nrp", "gene_names_refseq": "Nap1l1", "protein_names_uniprotkb": "Nucleosome assembly protein 1-like 1; Histone H2A-H2B chaperone NAP1L1; NAP-1-related protein", "protein_names_refseq": "NAP-1-related protein; histone H2A-H2B chaperone NAP1L1; nucleosome assembly protein 1-like 1", "tax_id": 10116, "disease": "appendiceal neoplasm (Disease Ontology:DOID:11240); pancreatic cancer (Disease Ontology:DOID:1793); hepatoblastoma (Disease Ontology:DOID:687)", "pathway": " (rno:89825)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;24893663;29209909", "class_list": "", "function": "Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Also participates in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Also stimulates homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Molecular dynamic simulation (MDS) of the two structures also revealed that rNAP1 dimer is more stable owing to the extensive hydrogen bonding in comparison to yNAP1. Further, in vitro kinase assay showed that the phosphorylation of rNAP1 favors oligomerization with no effect on its histone binding capacity, [RefSeq, PubMed]; The molecular interaction between DGKzeta and Nap1l1 was attenuated after hypoxic stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0019900 kinase binding;GO:0042393 histone binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042470 melanosome;GO:0000785 chromatin", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0071375 cellular response to peptide hormone stimulus;GO:2000179 positive regulation of neural precursor cell proliferation;GO:0014010 Schwann cell proliferation;GO:0050769 positive regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9Z2G8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80Z32-1", "uniprot_id": [ { "id": "ORC1_RAT", "url": "https://www.uniprot.org/uniprot/Q80Z32", "type": "external" } ], "mass": 95760.0, "length": 848, "protein_name": "Origin recognition complex subunit 1", "gene_name": "Orc1", "organism": "Rat", "refseq_name": "origin recognition complex subunit 1", "refseq_ac": [ { "id": "NP_808792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808792", "type": "external" } ], "gene_names_uniprotkb": "Orc1; Orc1l", "gene_names_refseq": "Orc1l; Orc1", "protein_names_uniprotkb": "Origin recognition complex subunit 1", "protein_names_refseq": "origin recognition complex subunit 1", "tax_id": 10116, "disease": "Meier-Gorlin syndrome 1 (Disease Ontology:DOID:0080512)", "pathway": " (rno:313479); (R-RNO-176187); (R-RNO-68616); (R-RNO-68689); (R-RNO-68949); (R-RNO-68962)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "18499104", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ORC1 gene silencing causes rat VSMCs to enter a reversible G(0) quiescent, growth arrested state; thus, ORC1 gene may be an important new target for suppressing VSMCs proliferation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005664 nuclear origin of replication recognition complex;GO:0000781 chromosome, telomeric region;GO:0000808 origin recognition complex", "go_biological_process": "GO:0048661 positive regulation of smooth muscle cell proliferation;GO:0006270 DNA replication initiation;GO:0070318 positive regulation of G0 to G1 transition;GO:0033314 mitotic DNA replication checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q80Z32-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R553-1", "uniprot_id": [ { "id": "CSTN3_RAT", "url": "https://www.uniprot.org/uniprot/Q8R553", "type": "external" } ], "mass": 105945.0, "length": 957, "protein_name": "Calsyntenin-3", "gene_name": "Clstn3", "organism": "Rat", "refseq_name": "calsyntenin-3 precursor", "refseq_ac": [ { "id": "NP_599203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599203", "type": "external" } ], "gene_names_uniprotkb": "Clstn3; Cs3; Cstn3", "gene_names_refseq": "Clstn3; Cs3; Cstn3", "protein_names_uniprotkb": "Calsyntenin-3", "protein_names_refseq": "alc-beta; alcadein-beta; calsyntenin-3 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:171393)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12498782;18158283;24094106", "class_list": "", "function": "Adipose-specific isoform that plays a key role in adaptive thermogenesis. Facilitates the efficient use of stored triglyceride by promoting multilocular morphology of thermogenic adipocytes: acts by inhibiting the activity of CIDEA and CIDEC on lipid droplets, thereby preventing lipid droplet fusion and facilitating lipid utilization. May also participate in adaptive thermogenesis by promoting sympathetic innervation of thermogenic adipose tissue: acts by driving secretion of neurotrophic factor S100B from brown adipocytes, stimulating neurite outgrowth from sympathetic neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with both neurexin-alpha and neurexin-beta proteins at the presynaptic membrane. Regulates the balance between excitatory and inhibitory synapses by inhibiting formation of excitatory parallel-fiber synapses and promoting formation of inhibitory synapses in the same neuron. May also be involved in ascorbate (vitamin C) uptake via its interaction with SLC23A2/SVCT2 (By similarity). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicate that calsyntenins function outside the nervous system and potentially are modulators of endocrine function., [RefSeq, PubMed]; The transmembrane form of calsyntenin-3 can trigger excitatory and inhibitory presynapse differentiation in contacting axons., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I5ZY11", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0005509 calcium ion binding;GO:0098632 cell-cell adhesion mediator activity;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0044232 organelle membrane contact site;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0097490 sympathetic neuron projection extension;GO:0010888 negative regulation of lipid storage;GO:1904861 excitatory synapse assembly;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8R553-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1S7-1", "uniprot_id": [ { "id": "OMD_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1S7", "type": "external" } ], "mass": 49783.0, "length": 423, "protein_name": "Osteomodulin", "gene_name": "Omd", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Omd", "gene_names_refseq": "", "protein_names_uniprotkb": "Osteomodulin; KSPG osteomodulin; Keratan sulfate proteoglycan osteomodulin; OSAD; Osteoadherin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:83717); (R-RNO-2022854); (R-RNO-2022857)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10607915", "class_list": "", "function": "May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0030500 regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z1S7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZK9-1", "uniprot_id": [ { "id": "DNS2B_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZK9", "type": "external" } ], "mass": 40472.0, "length": 356, "protein_name": "Deoxyribonuclease-2-beta", "gene_name": "Dnase2b", "organism": "Rat", "refseq_name": "deoxyribonuclease-2-beta precursor", "refseq_ac": [ { "id": "NP_067696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067696", "type": "external" } ], "gene_names_uniprotkb": "Dnase2b; Dlad", "gene_names_refseq": "Dlad; Dnase2b; UOX", "protein_names_uniprotkb": "Deoxyribonuclease-2-beta; 3.1.22.1; DNase II beta; DNase II-like acid DNase; DNase2-like acid DNase; Deoxyribonuclease II beta; Endonuclease DLAD", "protein_names_refseq": "DNA for uricase; DNase II beta; DNase II-like acid DNase; DNase2-like acid DNase; DNaseII-like acid DNase; deoxyribonuclease DLAD; deoxyribonuclease II beta; deoxyribonuclease-2-beta precursor; endonuclease DLAD", "tax_id": 10116, "disease": "cataract (Disease Ontology:DOID:83)", "pathway": " (rno:59296)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10558878", "class_list": "", "function": "Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004520 DNA endonuclease activity;GO:0004531 deoxyribonuclease II activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0006309 apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QZK9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1L0-1", "uniprot_id": [ { "id": "PK3CB_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1L0", "type": "external" } ], "mass": 122608.0, "length": 1070, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform", "gene_name": "Pik3cb", "organism": "Rat", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform", "refseq_ac": [ { "id": "NP_445933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445933", "type": "external" } ], "gene_names_uniprotkb": "Pik3cb", "gene_names_refseq": "Pik3cb", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; 2.7.1.153; 2.7.11.1; PI3-kinase subunit beta; PI3K-beta; PI3Kbeta; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; Serine/threonine protein kinase PIK3CB; p110beta", "protein_names_refseq": "PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K-beta; PI3Kbeta; PI3K; catalytic phosphatidylinositol 3-kinase beta; p110beta; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphoinositide-3-kinase, catalytic, beta polypeptide; ptdIns-3-kinase p110; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; serine/threonine protein kinase PIK3CB", "tax_id": 10116, "disease": "thrombosis (Disease Ontology:DOID:0060903); prostate cancer (Disease Ontology:DOID:10283); heart disease (Disease Ontology:DOID:114); endometrial cancer (Disease Ontology:DOID:1380); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); rectal benign neoplasm (Disease Ontology:DOID:1984); prostate adenocarcinoma (Disease Ontology:DOID:2526); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); glucose metabolism disease (Disease Ontology:DOID:4194); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:85243); (R-RNO-109704); (R-RNO-112399); (R-RNO-114604); (R-RNO-1257604); (R-RNO-1660499); (R-RNO-186763); (R-RNO-198203); (R-RNO-201556); (R-RNO-202424); (R-RNO-2029485); (R-RNO-210993); (R-RNO-2424491); (R-RNO-2730905); (R-RNO-389357); (R-RNO-4420097); (R-RNO-512988); (R-RNO-5673001); (R-RNO-6811558); (R-RNO-8853659); (R-RNO-9027276); (R-RNO-912526); (R-RNO-912631); (R-RNO-9842663); (R-RNO-9927354)", "pathway_count": 25, "publication_count": 7, "publication_id_list": "11931646;12213821;12360484;35717938;36739310;37338759;37815888", "class_list": "", "function": "Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats., [RefSeq, PubMed]; Blocking of PI3-kinase beta protects against cerebral ischemia/reperfusion injury by reducing platelet activation and downstream microvascular thrombosis in rats. Publication Status: Online-Only, [RefSeq, PubMed]; Data show a spatial separation of the inositol lipid signalling system between brush border membranes (BBM) and basolateral membranes (BLM); hepatocyte growth factor causes activation of PLC and PI3K in BLM leading to activation of PI3K-C2 beta in BBM, [RefSeq, PubMed]; In vivo regulation in retina through light-induced tyrosine phosphorylation of the insulin receptor beta-subunit, [RefSeq, PubMed]; MiR-107 Attenuates Sepsis-Induced Myocardial Injury by Targeting PTEN and Activating the PI3K/AKT Signaling Pathway., [RefSeq, PubMed]; Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G protein-coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Also has a protein kinase activity showing autophosphorylation., [UniProtKB, UniProtKB]; Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective Effect of Deltorphin II during Cardiac Reperfusion., [RefSeq, PubMed]; Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling. Erratum:[Aging (Albany NY). 2023 Dec 29;15(24):15703-15704. doi: 10.18632/aging.205458. PMID: 38157439], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "2.7.1.151", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.151", "type": "external" }, { "id": "2.7.1.140", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.140", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0043560 insulin receptor substrate binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0002931 response to ischemia;GO:0006897 endocytosis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z1L0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MF5-1", "uniprot_id": [ { "id": "IL11_RAT", "url": "https://www.uniprot.org/uniprot/Q99MF5", "type": "external" } ], "mass": 21555.0, "length": 199, "protein_name": "Interleukin-11", "gene_name": "Il11", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Il11", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-11; IL-11", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171040); (R-RNO-6788467)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11570967", "class_list": "", "function": "Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005142 interleukin-11 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0043235 receptor complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0033138 positive regulation of peptidyl-serine phosphorylation;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046888 negative regulation of hormone secretion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99MF5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0J6-1", "uniprot_id": [ { "id": "GDF15_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0J6", "type": "external" } ], "mass": 33439.0, "length": 303, "protein_name": "Growth/differentiation factor 15", "gene_name": "Gdf15", "organism": "Rat", "refseq_name": "growth/differentiation factor 15 precursor", "refseq_ac": [ { "id": "NP_062089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062089", "type": "external" } ], "gene_names_uniprotkb": "Gdf15; Sbf", "gene_names_refseq": "Gdf15", "protein_names_uniprotkb": "Growth/differentiation factor 15; GDF-15", "protein_names_refseq": "GDF-15; growth/differentiation factor 15 precursor", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); uterine fibroid (Disease Ontology:DOID:13223); anemia (Disease Ontology:DOID:2355)", "pathway": " (rno:29455)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "19103603;23435960;28846099;28953886;29144449;30554141;31852204;31928886;34019665;34187898;36336027;37060902;37584611", "class_list": "", "function": "Chronic peripheral ghrelin injection exerts antifibrotic effects by increasing growth differentiation factor 15 in rat hearts with myocardial fibrosis induced by isoproterenol., [RefSeq, PubMed]; Circulating GDF-15 is a biomarker of muscle loss in pulmonary arterial hypertension that is responsive to treatment., [RefSeq, PubMed]; Cross-species comparison of pregnancy-induced GDF15., [RefSeq, PubMed]; GDF15 Promotes Cardiac Fibrosis and Proliferation of Cardiac Fibroblasts via the MAPK/ERK1/2 Pathway after Irradiation in Rats., [RefSeq, PubMed]; GDF15 alleviates the progression of benign tracheobronchial stenosis by inhibiting epithelial-mesenchymal transition and inactivating fibroblasts., [RefSeq, PubMed]; Gdf15 expression exhibits increases >10-fold at night in the rat pineal gland, reaching levels that are >15-fold higher than the median in other tissues., [RefSeq, PubMed]; Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea and/or loss of appetite (PubMed:28846099, PubMed:28953886, PubMed:31928886, PubMed:34187898, PubMed:37060902). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (By similarity). Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28846099, PubMed:28953886, PubMed:37060902). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions (PubMed:37060902). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (By similarity). Contributes to the effect of metformin, an anti-diabetic drug, on appetite reduction and weight loss: produced in the kidney in response to metformin treatment, thereby activating the GDF15-GFRAL response, leading to reduced appetite and weight (PubMed:37060902). Required for avoidance behavior in response to food allergens: induced downstream of mast cell activation to promote aversion and minimize harmful effects of exposure to noxious substances (By similarity). Produced in response to anticancer drugs, such as camptothecin or cisplatin, promoting nausea and contributing to malnutrition (By similarity). Overproduced in many cancers, promoting anorexia in cancer (cachexia) (By similarity). Responsible for the risk of nausea during pregnancy: high levels of GDF15 during pregnancy, mostly originating from embryos, are associated with increased nausea (By similarity). Maternal sensitivity to nausea is probably determined by pre-pregnancy exposure to GDF15, females with naturally high level of GDF15 being less susceptible to nausea than female rats with low levels of GDF15 before pregnancy (By similarity). Promotes metabolic adaptation in response to systemic inflammation caused by bacterial and viral infections in order to promote tissue tolerance and prevent tissue damage (By similarity). Required for tissue tolerance in response to myocardial infarction by acting as an inhibitor of leukocyte integring activation, thereby protecting against cardiac rupture (By similarity). Inhibits growth hormone signaling on hepatocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Up-regulation of EGR-1 and NAG-1, along with higher reactive oxygen species load may positively regulate the intrinsic pathway of apoptosis for the NSAID mediated chemoprevention of colorectal cancer., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0002686 negative regulation of leukocyte migration;GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9Z0J6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGL2-1", "uniprot_id": [ { "id": "NTAL_RAT", "url": "https://www.uniprot.org/uniprot/Q8CGL2", "type": "external" } ], "mass": 23130.0, "length": 204, "protein_name": "Linker for activation of T-cells family member 2", "gene_name": "Lat2", "organism": "Rat", "refseq_name": "linker for activation of T-cells family member 2", "refseq_ac": [ { "id": "NP_776212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776212", "type": "external" } ], "gene_names_uniprotkb": "Lat2; Lab; Ntal; Wbscr5", "gene_names_refseq": "Lat2; Ntal; Wbscr5", "protein_names_uniprotkb": "Linker for activation of T-cells family member 2; Linker for activation of B-cells; Non-T-cell activation linker", "protein_names_refseq": "LAT-2 like; Williams-Beuren syndrome chromosome region 5 homolog; Williams-Beuren syndrome chromosome region 5-like protein; linker for activation of B-cells; linker for activation of T-cells family member 2; non-T cell activation linker", "tax_id": 10116, "disease": "Williams-Beuren syndrome (Disease Ontology:DOID:1928)", "pathway": " (rno:317676); (R-RNO-2730905)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15477348;21403644;23443658;26448619;29099056", "class_list": "", "function": "Chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family, [RefSeq, PubMed]; Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2 (By similarity)., [UniProtKB]; LAT2 and LAT1 form separate membrane microdomains in rat basophilic leukemia cells., [RefSeq, PubMed]; The Saturday night forecast called for possible showers or thunderstorms, with winds of 20 to 26 mph. The expected total rainfall Saturday ranges from six-tenths of an inch to an inch, with more possible in thunderstorms, the weather service said., [RefSeq, PubMed]; These results suggest that increased asymmetric dimethylarginine (ADMA) efflux mediated by upregulated yLAT2 may be a mechanism by which ammonia interferes with intra-astrocytic (and possibly intra-endothelial cell) ADMA content and subsequently, NO synthesis in both cell types. Publication Status: Online-Only, [RefSeq, PubMed]; Up-regulation of y(+)LAT2 transporter is coupled with increased inducible nitric oxide synthase (iNOS) expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042169 SH2 domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0035556 intracellular signal transduction;GO:0042113 B cell activation;GO:0002250 adaptive immune response;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8CGL2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z250-1", "uniprot_id": [ { "id": "LIN7A_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z250", "type": "external" } ], "mass": 25865.0, "length": 232, "protein_name": "Protein lin-7 homolog A", "gene_name": "Lin7a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lin7a; Mals1; Veli1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein lin-7 homolog A; Lin-7A; MALS-1; Mammalian lin-seven protein 1; Veli-1; Vertebrate lin-7 homolog 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:85327); (R-RNO-212676)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10341223;10362251;12040031;12393911;14960569;15024025;15494546;17604280;9753324", "class_list": "", "function": "Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z251", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0030165 PDZ domain binding;GO:0097016 L27 domain binding", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0015031 protein transport;GO:0007269 neurotransmitter secretion;GO:0048839 inner ear development;GO:0006887 exocytosis;GO:0048489 synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9Z250-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K582-1", "uniprot_id": [ { "id": "DUS1L_RAT", "url": "https://www.uniprot.org/uniprot/Q8K582", "type": "external" } ], "mass": 49709.0, "length": 438, "protein_name": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like", "gene_name": "Dus1l", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dus1l; Pp3111", "gene_names_refseq": "", "protein_names_uniprotkb": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; 1.3.1.88; Liver regeneration-related protein LRRG08/LRRG09; tRNA-dihydrouridine synthase 1-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:246185)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U16 and U17 in cytoplasmic tRNAs. Affects the level of some mature tRNA and thereby the total cellular translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.88", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.88", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0017150 tRNA dihydrouridine synthase activity;GO:0102262 tRNA-dihydrouridine16 synthase activity;GO:0102263 tRNA-dihydrouridine17 synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002943 tRNA dihydrouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K582-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTS8-1", "uniprot_id": [ { "id": "FCN1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTS8", "type": "external" } ], "mass": 36627.0, "length": 335, "protein_name": "Ficolin-1", "gene_name": "Fcn1; Fcna", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fcn1; Fcna; Fcn1; Fcna", "gene_names_refseq": "", "protein_names_uniprotkb": "Ficolin-1; Collagen/fibrinogen domain-containing protein 1; Ficolin-A; Ficolin-alpha; M-ficolin", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:83517); (R-RNO-2855086); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Extracellular lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding;GO:0003823 antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032757 positive regulation of interleukin-8 production;GO:0001867 complement activation, lectin pathway;GO:0002752 cell surface pattern recognition receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WTS8-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WE5-1", "uniprot_id": [ { "id": "LHPL1_RAT", "url": "https://www.uniprot.org/uniprot/Q80WE5", "type": "external" } ], "mass": 23746.0, "length": 220, "protein_name": "LHFPL tetraspan subfamily member 1 protein", "gene_name": "Lhfpl1", "organism": "Rat", "refseq_name": "LHFPL tetraspan subfamily member 1 protein precursor", "refseq_ac": [ { "id": "NP_851599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851599", "type": "external" } ], "gene_names_uniprotkb": "Lhfpl1; Lhfp", "gene_names_refseq": "Lhfpl1; Lhfp", "protein_names_uniprotkb": "LHFPL tetraspan subfamily member 1 protein; Lipoma HMGIC fusion partner-like 1 protein", "protein_names_refseq": "LHFPL tetraspan subfamily member 1 protein precursor; LHFPL tetraspan subfamily member 1 protein; lipoma HMGIC fusion partner-like 1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:300286)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80WE5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80XF7-1", "uniprot_id": [ { "id": "CXG2_RAT", "url": "https://www.uniprot.org/uniprot/Q80XF7", "type": "external" } ], "mass": 46990.0, "length": 440, "protein_name": "Gap junction gamma-2 protein", "gene_name": "Gjc2", "organism": "Rat", "refseq_name": "gap junction gamma-2 protein", "refseq_ac": [ { "id": "NP_001094254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094254", "type": "external" } ], "gene_names_uniprotkb": "Gjc2; Gja12", "gene_names_refseq": "Cx47; Gja12; Gjc2", "protein_names_uniprotkb": "Gap junction gamma-2 protein; Connexin-47; Cx47; Gap junction alpha-12 protein", "protein_names_refseq": "connexin-47; gap junction alpha-12 protein; gap junction gamma-2 protein; gap junction membrane channel protein alpha 12; gap junction protein, alpha 12", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy 2 (Disease Ontology:DOID:0060787); hereditary lymphedema IC (Disease Ontology:DOID:0070208); hereditary spastic paraplegia 44 (Disease Ontology:DOID:0110796); Parkinson's disease (Disease Ontology:DOID:14330); lymphedema (Disease Ontology:DOID:4977)", "pathway": " (rno:497913); (R-RNO-190861)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15293232;16194882;28278052;28634078;31002152", "class_list": "", "function": "Astrocytes can cause Ca(2+) signaling activation, ERK1/2 phosphorylation, and Id4 expression stimulation in oligodendrocyte progenitor cells inducing proliferation of these cells, mainly through Cx47., [RefSeq, PubMed]; Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of Chi3l1 expression., [RefSeq, PubMed]; Astrocytes regulate the expression of S1pR3 in oligodendrocyte progenitor cells via Cx47, which could be a valuable approach for promoting oligodendrocyte progenitor cells proliferation., [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems (By similarity)., [UniProtKB]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1903763 gap junction channel activity involved in cell communication by electrical coupling;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0043209 myelin sheath;GO:0005921 gap junction", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0010628 positive regulation of gene expression;GO:0009636 response to toxic substance;GO:0001932 regulation of protein phosphorylation;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q80XF7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q812E8-1", "uniprot_id": [ { "id": "NADE_RAT", "url": "https://www.uniprot.org/uniprot/Q812E8", "type": "external" } ], "mass": 81511.0, "length": 725, "protein_name": "Glutamine-dependent NAD(+) synthetase", "gene_name": "Nadsyn1", "organism": "Rat", "refseq_name": "glutamine-dependent NAD(+) synthetase", "refseq_ac": [ { "id": "NP_852145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852145", "type": "external" } ], "gene_names_uniprotkb": "Nadsyn1; Qns1", "gene_names_refseq": "Nadsyn1", "protein_names_uniprotkb": "Glutamine-dependent NAD(+) synthetase; 6.3.5.1; NAD(+) synthase [glutamine-hydrolyzing]; NAD(+) synthetase", "protein_names_refseq": "NAD(+) synthase; NAD(+) synthetase; glutamine-dependent NAD(+) synthetase", "tax_id": 10116, "disease": "high grade glioma (Disease Ontology:DOID:3070)", "pathway": " (rno:353255); (R-RNO-196807)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity;GO:0004359 glutaminase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009435 NAD+ biosynthetic process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q812E8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CG08-1", "uniprot_id": [ { "id": "CTHR1_RAT", "url": "https://www.uniprot.org/uniprot/Q8CG08", "type": "external" } ], "mass": 26424.0, "length": 245, "protein_name": "Collagen triple helix repeat-containing protein 1", "gene_name": "Cthrc1", "organism": "Rat", "refseq_name": "collagen triple helix repeat-containing protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_758836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758836", "type": "external" } ], "gene_names_uniprotkb": "Cthrc1", "gene_names_refseq": "Cthrc1", "protein_names_uniprotkb": "Collagen triple helix repeat-containing protein 1", "protein_names_refseq": "collagen triple helix repeat-containing protein 1 isoform 1 precursor; collagen triple helix repeat-containing protein 1", "tax_id": 10116, "disease": "Barrett's esophagus (Disease Ontology:DOID:9206)", "pathway": " (rno:282836)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15618538;17322174;18467647;28647773;29357417;29393342", "class_list": "", "function": "CTHRC1 downregulation suppresses IL-1beta-induced JNK1/2 activation., [RefSeq, PubMed]; CTHRC1 is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration., [RefSeq, PubMed]; Cthrc1 has role in bladder growth following denervation., [RefSeq, PubMed]; Cthrc1 is a cell-type-specific inhibitor of transforming growth factor-beta, which in turn impacts collagen type I and III deposition, neointimal formation, and dedifferentiation of smooth muscle cells. Erratum:[Circ Res. 2012 May 11;110(10):e72], [RefSeq, PubMed]; Intracellular localization of Cthrc1 characterizes differentiated smooth muscle., [RefSeq, PubMed]; Its overexpression in smooth muscle cell lines increases their migratory ability and inhibits collagen type I expression. May act as a negative regulator of collagen matrix deposition., [UniProtKB]; Overexpression of CHTRC1 increased osteogenic differentiation of periodontal ligament stem cells, which could be abolished by TAZ siRNA., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004666 prostaglandin-endoperoxide synthase activity;GO:0005109 frizzled binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0043005 neuron projection", "go_biological_process": "GO:0016477 cell migration;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0033690 positive regulation of osteoblast proliferation;GO:0060071 Wnt signaling pathway, planar cell polarity pathway;GO:0045669 positive regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8CG08-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJH6-1", "uniprot_id": [ { "id": "NPAS4_RAT", "url": "https://www.uniprot.org/uniprot/Q8CJH6", "type": "external" } ], "mass": 87318.0, "length": 802, "protein_name": "Neuronal PAS domain-containing protein 4", "gene_name": "Npas4", "organism": "Rat", "refseq_name": "neuronal PAS domain-containing protein 4", "refseq_ac": [ { "id": "NP_705890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705890", "type": "external" } ], "gene_names_uniprotkb": "Npas4; Nxf", "gene_names_refseq": "Npas4; Nxf", "protein_names_uniprotkb": "Neuronal PAS domain-containing protein 4; HLH-PAS transcription factor NXF; Neuronal PAS4", "protein_names_refseq": "HLH-PAS transcription factor NXF; bHLH-PAS type transcription factor NXF; neuronal PAS domain-containing protein 4; neuronal PAS4", "tax_id": 10116, "disease": "", "pathway": " (rno:266734); (R-RNO-9768919)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "14701734;18815592;19001414;19083991;21887312;28957664;29196218;29899116;31041873;31883511", "class_list": "", "function": "In healthy cerebellar granule neurons HDAC3 associates weakly with the Npas4 promoter, however, this association is robustly increased in neurons primed to die. Study found that HDAC3 also associates differentially with the Bdnfr gene promoter, with higher association in dying neurons. Overexpression of HDAC3 leads to a suppression of Npas4 and Bdnf expression in cortical neurons. Publication Status: Online-Only, [RefSeq, PubMed]; NXF gene could be induced in response to several neurodegenerative stimuli/excitations for the cell protection, and thus provide an 'on demand' cell-protection system in nervous tissue, [RefSeq, PubMed]; NXF, is a new member genes under the control of neurotrophin BDNF., [RefSeq, PubMed]; Nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model. We also discovered that HDAC5 associates with an activity-sensitive enhancer of the Npas4 gene and negatively regulates NPAS4 expression., [RefSeq, PubMed]; Preoperative anxiety led to GABAergic system impairment in spinal cord and thus caused hyperalgesia due to glucocorticoid-induced downregulation of neuronal PAS domain protein 4., [RefSeq, PubMed]; The main discovery of this study is that the spontaneously expressed hippocampus Npas4 mRNA level under stressful conditions is associated with differences in hippocampus activation and behavior, [RefSeq, PubMed]; The presence of multiple localization signals and the differentiated localization of NPAS4 suggest a precise, multifactor-dependent regulation of NPAS4 trafficking, potentially crucial for its ability to act as a cellular stress sensor and transcription factor., [RefSeq, PubMed]; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (PubMed:21887312). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (By similarity). Can activate the CME (CNS midline enhancer) element (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0098794 postsynapse;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007612 learning;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q8CJH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4D6-1", "uniprot_id": [ { "id": "CP4X1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4D6", "type": "external" } ], "mass": 58574.0, "length": 507, "protein_name": "Cytochrome P450 4X1", "gene_name": "Cyp4x1", "organism": "Rat", "refseq_name": "cytochrome P450 4X1", "refseq_ac": [ { "id": "NP_663708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663708", "type": "external" } ], "gene_names_uniprotkb": "Cyp4x1", "gene_names_refseq": "Cyp4x1", "protein_names_uniprotkb": "Cytochrome P450 4X1; 1.14.14.-; CYPIVX1", "protein_names_refseq": "CYPIVX1; cytochrome P450 4X1", "tax_id": 10116, "disease": "", "pathway": " (rno:246767)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12176035;25055826", "class_list": "", "function": "A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB]; Molecular cloning & specific localization of Cyp4x1 to the brain, [RefSeq, PubMed]; These data suggest there is circadian regulation of Cyp4x1 and Cyp2c11 gene expression, and that eicosanoid production may contribute to circadian changes in blood flow and alter the risk of adverse cardiovascular events throughout the day., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0062189 anandamide 14,15 epoxidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K4D6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4Q9-1", "uniprot_id": [ { "id": "CXA8_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4Q9", "type": "external" } ], "mass": 49401.0, "length": 440, "protein_name": "Gap junction alpha-8 protein", "gene_name": "Gja8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gja8", "gene_names_refseq": "", "protein_names_uniprotkb": "Gap junction alpha-8 protein; Connexin-50; Cx50", "protein_names_refseq": "", "tax_id": 10116, "disease": "cataract 1 multiple types (Disease Ontology:DOID:0110231); microphthalmia (Disease Ontology:DOID:10629); cataract (Disease Ontology:DOID:83)", "pathway": " (R-RNO-190861)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12356818;1325220", "class_list": "", "function": "Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0043010 camera-type eye development;GO:0002088 lens development in camera-type eye;GO:1990349 gap junction-mediated intercellular transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8K4Q9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4Y5-1", "uniprot_id": [ { "id": "LGI1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4Y5", "type": "external" } ], "mass": 63728.0, "length": 557, "protein_name": "Leucine-rich glioma-inactivated protein 1", "gene_name": "Lgi1", "organism": "Rat", "refseq_name": "leucine-rich glioma-inactivated protein 1 precursor", "refseq_ac": [ { "id": "NP_665712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665712", "type": "external" } ], "gene_names_uniprotkb": "Lgi1", "gene_names_refseq": "Lgi1", "protein_names_uniprotkb": "Leucine-rich glioma-inactivated protein 1", "protein_names_refseq": "leucine-rich glioma-inactivated protein 1 precursor; leucine-rich glioma-inactivated protein 1-like; leucine-rich glioma-inactivated protein 1; leucine-rich repeat LGI family, member 1", "tax_id": 10116, "disease": "familial temporal lobe epilepsy 1 (Disease Ontology:DOID:0060748); epilepsy (Disease Ontology:DOID:1826); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725)", "pathway": " (rno:252892); (R-RNO-5682910)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12217514;16504945;16990550;24406746;30598502;30813600;35294724;38700985;38843836", "class_list": "", "function": "ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment. Publication Status: Online-Only, [RefSeq, PubMed]; Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission., [RefSeq, PubMed]; He down-regulation of Kir4.1 channels in astrocytes is involved in audiogenic epileptogenesis caused by Lgi1 mutation. Publication Status: Online-Only, [RefSeq, PubMed]; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; TLR4 activation inhibits the proliferation and osteogenic differentiation of skeletal muscle stem cells by downregulating LGI1., [RefSeq, PubMed]; These results of this study suggest that Lgi1(L385R/+) rats are useful as an animal model of human autosomal dominant lateral temporal lobe epilepsy., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5FWS7", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043083 synaptic cleft", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0031175 neuron projection development;GO:0007411 axon guidance;GO:0050806 positive regulation of synaptic transmission;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8K4Y5-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K560-1", "uniprot_id": [ { "id": "OTOSP_RAT", "url": "https://www.uniprot.org/uniprot/Q8K560", "type": "external" } ], "mass": 10095.0, "length": 89, "protein_name": "Otospiralin", "gene_name": "Otos", "organism": "Rat", "refseq_name": "otospiralin precursor", "refseq_ac": [ { "id": "NP_631927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631927", "type": "external" } ], "gene_names_uniprotkb": "Otos", "gene_names_refseq": "Otos", "protein_names_uniprotkb": "Otospiralin", "protein_names_refseq": "otospiralin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:246044)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11880501", "class_list": "", "function": "May be essential for the survival of the neurosensory epithelium of the inner ear., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K560-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K5A3-1", "uniprot_id": [ { "id": "CST11_RAT", "url": "https://www.uniprot.org/uniprot/Q8K5A3", "type": "external" } ], "mass": 16686.0, "length": 139, "protein_name": "Cystatin-11", "gene_name": "Cst11", "organism": "Rat", "refseq_name": "cystatin-11 precursor", "refseq_ac": [ { "id": "NP_620785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620785", "type": "external" } ], "gene_names_uniprotkb": "Cst11", "gene_names_refseq": "Cst11", "protein_names_uniprotkb": "Cystatin-11", "protein_names_refseq": "cystatin-11 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:245916)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0061827 sperm head;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0036126 sperm flagellum", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0048678 response to axon injury;GO:0030521 androgen receptor signaling pathway;GO:0031640 killing of cells of another organism;GO:0007431 salivary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K5A3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R456-1", "uniprot_id": [ { "id": "OPN4_RAT", "url": "https://www.uniprot.org/uniprot/Q8R456", "type": "external" } ], "mass": 52407.0, "length": 474, "protein_name": "Melanopsin", "gene_name": "Opn4", "organism": "Rat", "refseq_name": "melanopsin", "refseq_ac": [ { "id": "NP_620215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620215", "type": "external" } ], "gene_names_uniprotkb": "Opn4", "gene_names_refseq": "Opn4", "protein_names_uniprotkb": "Melanopsin; Opsin-4", "protein_names_refseq": "melanopsin", "tax_id": 10116, "disease": "retinitis pigmentosa 4 (Disease Ontology:DOID:0110372); sensorineural hearing loss (Disease Ontology:DOID:10003); retinitis pigmentosa (Disease Ontology:DOID:10584); retinal disease (Disease Ontology:DOID:5679); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:192223); (R-RNO-416476); (R-RNO-419771)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11834834;12904470;14500998;15073514;19413349;23541830;25378407;26176868;26572076", "class_list": "", "function": "Data indicate that the phosphorylation status of melanopsin influences its functions., [RefSeq, PubMed]; During rat retinal development melanopsin is expressed at prenatal day 18 in cells of the inner neuroblast layer. and During early postnatal development a melanopsin immunoreactive dendritic network is formed in the inner plexiform layer., [RefSeq, PubMed]; During retinal degeneration, the expression of melanopsin was significantly decreased, while vector-mediated overexpression of melanopsin delayed the loss of visual function in rats., [RefSeq, PubMed]; Early light exposure can increase the number of melanopsin immunopositive retinal ganalion cells through a process dependent on intrinsic photosensitive spiking activity., [RefSeq, PubMed]; Following ON injury or retrograde tracing there is a transient melanopsin downregulation that should be taken into account when assessing m(+)RGC survival., [RefSeq, PubMed]; G protein-coupled photoreceptor that signals through the G(q/11) family of G proteins in response to light in intrinsically photosensitive retinal ganglion cells (ipRGCs). Can also activate other G proteins, including G(i/o) and G(s), depending on the cell type, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent signaling. Activation occurs when opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (By similarity). Acts as a bistable protein, allowing photoreversible regeneration of the cis-retinal chromophore after stimulation (By similarity). Contributes to non-image-forming visual response to light in ipRGCs, including the pupillary light reflex and the regulation of circadian rhythms. In M1 ipRGCs (non-image forming) subtypes, activates a G(q)-phospholipase C (PLC) signaling cascade leading to depolarization through opening of TRPC6/7 channels and decreased intrisic excitability. Mediates phototransduction in M4 ipRGCs (image forming) subtypes across dim to bright light conditions via G(q)-PLC signaling, resulting in increased intrisic excitability through closure of potassium leak channels (most likely TASK channels), thereby enhancing contrast sensitivity. At bright light intensities, further enhances depolarization in M4 ipRGCs via activation of TRPC channels. Functions in the iris to control the intrinsic pupillary light reflex in nocturnal/crepuscular non-primate mammals. May be involved in the optokinetic visual tracking response. May also play a role in regulating retinal hyaloid vessel growth and regression (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Melanopsin expression defines a subset of RGCs that play a broad role in regulation of nonvisual photoreception, providing projections that contribute to circadian entrainment, negative masking, regulation of sleep-wake states, and the pupillary reflex, [RefSeq, PubMed]; Melanopsin, in itself, is not necessary for circadian photoreception. In fact, it appears that of the known photoreceptor systems, none, in and of itself, is necessary for circadian photoreception., [RefSeq, PubMed]; Photoreceptor that binds cis-retinaldehydes. Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light. May be involved in the optokinetic visual tracking response. May be involved in the regulation of retinal hyaloid vessel growth and regression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005502 11-cis retinal binding;GO:0008020 G protein-coupled photoreceptor activity;GO:0004930 G protein-coupled receptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:1990384 hyaloid vascular plexus regression;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0045938 positive regulation of circadian sleep/wake cycle, sleep", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8R456-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4G1-1", "uniprot_id": [ { "id": "MRGX1_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4G1", "type": "external" } ], "mass": 37074.0, "length": 323, "protein_name": "Mas-related G protein-coupled receptor member X1", "gene_name": "Mrgprx1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mrgprx1; Mrgc; Mrgprc11; Mrgprc; Mrgprx4; Snsr1; Snsr", "gene_names_refseq": "", "protein_names_uniprotkb": "Mas-related G protein-coupled receptor member X1; Sensory neuron-specific G protein-coupled receptor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:282547)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11850634;12909716", "class_list": "", "function": "G protein-coupled receptor specifically expressed in sensory neurons of dorsal root ganglion, and which is involved in itch perception and pain transmission. Specifically activated by a variety of enkephalin (PENK) neuropeptides, such as BAM22 and BAM8-22, which induce itch in a histamine-independent manner. Activated by some tick defensins, such as I.persulcatus Def1 and I.ricinus Def2, evoking itch. Also activated following cleavage by the dust mite cysteine protease Der p1. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. MRGPRX1 is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, leading to sensitize TRPV1 in pruriceptors, while G(i) coupling mediates inhibition of adenylate cyclase activity. Activation of MRGPRX1 in the peripheral nervous system elicits itch, evoking scratching (By similarity). MRGPRX1 activation in sensory neurons of the nasal mucosa mediates sneezing responses to irritants or influenza-virus (By similarity). Activation in the central nervous system dampens chronic pain: BAM8-22-binding at the central terminals prevents pain signals passing to spinal cord neurons, attenuating spinal nociceptive transmission (By similarity). Activation by CXCL17 induces chemotactic movement (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN42", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0016493 C-C chemokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:1904057 negative regulation of sensory perception of pain;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R4G1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VBX1-1", "uniprot_id": [ { "id": "LIPG_RAT", "url": "https://www.uniprot.org/uniprot/Q8VBX1", "type": "external" } ], "mass": 55924.0, "length": 493, "protein_name": "Endothelial lipase", "gene_name": "Lipg", "organism": "Rat", "refseq_name": "endothelial lipase precursor", "refseq_ac": [ { "id": "NP_001012759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012759", "type": "external" } ], "gene_names_uniprotkb": "Lipg", "gene_names_refseq": "Lipg; lipase", "protein_names_uniprotkb": "Endothelial lipase; 3.1.1.32; 3.1.1.3; EDL; Endothelial-derived lipase; Phospholipase A1", "protein_names_refseq": "EDL; endothelial lipase precursor; endothelial lipase; endothelial-derived lipase; lipase, endothelial; phospholipase A1", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); cardiovascular system disease (Disease Ontology:DOID:1287); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); myocardial infarction (Disease Ontology:DOID:5844); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:291437); (R-RNO-8964058)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11924532;15914124;19931348", "class_list": "", "function": "Data show that endothelial lipase (EL) was upregulated in rat atherosclerosis and taht lipopolysaccharide stimulates EL expression in vitro through NFkappaB activation., [RefSeq, PubMed]; Exerts both phospholipase and triglyceride lipase activities (By similarity). More active as a phospholipase than a triglyceride lipase (By similarity). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (By similarity). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (By similarity)., [UniProtKB, UniProtKB]; Exerts both phospholipase and triglyceride lipase activities. More active as a phospholipase than a triglyceride lipase. Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5D216", "ec_number_list": [ { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" } ], "go_molecular_function": "GO:0008201 heparin binding;GO:0004620 phospholipase activity;GO:0008970 phospholipase A1 activity;GO:0004806 triacylglycerol lipase activity;GO:0004465 lipoprotein lipase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0009986 cell surface;GO:0005576 extracellular region", "go_biological_process": "GO:0007584 response to nutrient;GO:0006633 fatty acid biosynthetic process;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis;GO:0043691 reverse cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8VBX1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHZ4-1", "uniprot_id": [ { "id": "PNMA1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHZ4", "type": "external" } ], "mass": 39793.0, "length": 353, "protein_name": "Paraneoplastic antigen Ma1 homolog", "gene_name": "Pnma1", "organism": "Rat", "refseq_name": "paraneoplastic antigen Ma1 homolog", "refseq_ac": [ { "id": "NP_570833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570833", "type": "external" } ], "gene_names_uniprotkb": "Pnma1; Ma1", "gene_names_refseq": "MA1; Pnma1", "protein_names_uniprotkb": "Paraneoplastic antigen Ma1 homolog", "protein_names_refseq": "paraneoplastic Ma antigen 1; paraneoplastic antigen Ma1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:170636)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10050892;20936693", "class_list": "", "function": "PNMA1 functions to promote neuronal death. PNMA1-mediated apoptosis can be prevented by Bcl2. Although the detailed mechanism remains to be delineated, it is likely to involve association of proteins with PNMA1 through its BH3-like sequence., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8N4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002437 inflammatory response to antigenic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VHZ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XJ0-1", "uniprot_id": [ { "id": "CREST_RAT", "url": "https://www.uniprot.org/uniprot/Q91XJ0", "type": "external" } ], "mass": 43999.0, "length": 401, "protein_name": "Calcium-responsive transcription coactivator", "gene_name": "Ss18l1", "organism": "Rat", "refseq_name": "calcium-responsive transcription coactivator", "refseq_ac": [ { "id": "NP_620273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620273", "type": "external" } ], "gene_names_uniprotkb": "Ss18l1; Crest", "gene_names_refseq": "CREST; Ss18l1", "protein_names_uniprotkb": "Calcium-responsive transcription coactivator; SS18-like protein 1", "protein_names_refseq": "SS18-like protein 1; SS18L1, nBAF chromatin remodeling complex subunit; calcium-responsive transactivator; calcium-responsive transcription coactivator; synovial sarcoma translocation gene on chromosome 18-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:192352); (R-RNO-9933937); (R-RNO-9933947)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "14716005;15488321;15866867;19081374;23160962;30228227;33398438", "class_list": "", "function": "Analysis of the CREST domain that inhibits dendritic growth in cultured neurons, [RefSeq, PubMed]; CREST in the nucleus accumbens core is required for cocaine-induced conditioned place preference, synaptic plasticity and cocaine-seeking behavior., [RefSeq, PubMed]; Calcium activation of CREST-mediated transcription helps regulate neuronal morphogenesis, [RefSeq, PubMed]; Protein expression pattern of calcium-responsive transactivator in early postnatal and adult testes., [RefSeq, PubMed]; The results indicated that CREST is implicated in beta-cell apoptosis induced by culture in high glucose. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0071565 nBAF complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016358 dendrite development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q91XJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XN4-1", "uniprot_id": [ { "id": "BAMBI_RAT", "url": "https://www.uniprot.org/uniprot/Q91XN4", "type": "external" } ], "mass": 29143.0, "length": 260, "protein_name": "BMP and activin membrane-bound inhibitor homolog", "gene_name": "Bambi", "organism": "Rat", "refseq_name": "BMP and activin membrane-bound inhibitor homolog precursor", "refseq_ac": [ { "id": "NP_620782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620782", "type": "external" } ], "gene_names_uniprotkb": "Bambi", "gene_names_refseq": "Bambi", "protein_names_uniprotkb": "BMP and activin membrane-bound inhibitor homolog; Kinase-deficient TGFbeta superfamily receptor subunit", "protein_names_refseq": "BMP and activin membrane-bound inhibitor homolog precursor; BMP and activin membrane-bound inhibitor, homolog; kinase-deficient TGFbeta superfamily receptor subunit", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); prostatitis (Disease Ontology:DOID:14654); aortic valve stenosis (Disease Ontology:DOID:1712); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung non-small cell carcinoma (Disease Ontology:DOID:3908); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:83837); (R-RNO-2173788)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12933693;28035406;29424488;31636010", "class_list": "", "function": "BAMBI plays a neuroprotective role by decreasing inflammation and activating autophagy in rats with SCI., [RefSeq, PubMed]; Downregulation of circDNMT3B contributes to vascular dysfunction in diabetic retinas through regulating miR-20b-5p and BAMBI, providing a potential treatment strategy for diabetic retinopathy, [RefSeq, PubMed]; Negatively regulates TGF-beta signaling., [UniProtKB, UniProtKB, UniProtKB]; Regulated Bambi mRNA synthesis may contribute to TGF beta superfamily signaling modulation in several organs, as suggested by its discrete expression switch in male germ cells., [RefSeq, PubMed]; These findings indicate that LPS increases TGF-beta1 production through paracrine and autocrine mechanisms and that LPS enhances TGF-beta1 signalling in PSCs by repressing BAMBI via TLR4/MyD88/NF-kB activation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0045893 positive regulation of DNA-templated transcription;GO:0030514 negative regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q91XN4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XU7-1", "uniprot_id": [ { "id": "CDHR1_RAT", "url": "https://www.uniprot.org/uniprot/Q91XU7", "type": "external" } ], "mass": 93764.0, "length": 859, "protein_name": "Cadherin-related family member 1", "gene_name": "Cdhr1", "organism": "Rat", "refseq_name": "cadherin-related family member 1 precursor", "refseq_ac": [ { "id": "NP_446024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446024", "type": "external" } ], "gene_names_uniprotkb": "Cdhr1; Kiaa1775; Pcdh21; Prcad", "gene_names_refseq": "Cdhr1; Pcdh21", "protein_names_uniprotkb": "Cadherin-related family member 1; MT-protocadherin; Photoreceptor cadherin; Protocadherin-21; prCAD", "protein_names_refseq": "MT-protocadherin; cadherin-related family member 1 precursor; photoreceptor cadherin; prCAD; protocadherin-21", "tax_id": 10116, "disease": "cone-rod dystrophy 15 (Disease Ontology:DOID:0111021)", "pathway": " (rno:93662)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11597768;11738025", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0045494 photoreceptor cell maintenance;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0035845 photoreceptor cell outer segment organization;GO:0008594 photoreceptor cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91XU7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Y94-1", "uniprot_id": [ { "id": "COX42_RAT", "url": "https://www.uniprot.org/uniprot/Q91Y94", "type": "external" } ], "mass": 20170.0, "length": 172, "protein_name": "Cytochrome c oxidase subunit 4 isoform 2, mitochondrial", "gene_name": "Cox4i2", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform 2 precursor", "refseq_ac": [ { "id": "NP_445924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445924", "type": "external" } ], "gene_names_uniprotkb": "Cox4i2; Cox4b", "gene_names_refseq": "Cox4b; Cox4i2; CoxIV-2", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 4 isoform 2, mitochondrial; COX IV-2; Cytochrome c oxidase subunit IV isoform 2", "protein_names_refseq": "COX IV-2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform 2 precursor; cytochrome c oxidase subunit IV; cytochrome c oxidase, subunit 4b; cytochrome c oxidase, subunit IVb", "tax_id": 10116, "disease": "cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762)", "pathway": " (rno:84683); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11311561;21641552;29991768", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Microwave induced mitochondrial ROS production activated HIF-1alpha and regulated COXIV-1 expression to restore mitochondria functions. Therefore, HIF-1alpha might be a potential target to impair microwave induced injuries. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial energy metabolism regulation by phosphorylation of COXIV-1 is coupled with prevention of COX allosteric inhibition by ATP, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0071456 cellular response to hypoxia;GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q91Y94-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920L6-1", "uniprot_id": [ { "id": "ELOV6_RAT", "url": "https://www.uniprot.org/uniprot/Q920L6", "type": "external" } ], "mass": 31624.0, "length": 267, "protein_name": "Very long chain fatty acid elongase 6", "gene_name": "Elovl6", "organism": "Rat", "refseq_name": "very long chain fatty acid elongase 6", "refseq_ac": [ { "id": "NP_599210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599210", "type": "external" } ], "gene_names_uniprotkb": "Elovl6; Face; Lce", "gene_names_refseq": "Elovl6; Lce2; rELO2", "protein_names_uniprotkb": "Very long chain fatty acid elongase 6; 2.3.1.199; 3-keto acyl-CoA synthase Elovl6; ELOVL FA elongase 6; ELOVL fatty acid elongase 6; Elongation of very long chain fatty acids protein 6; Fatty acid elongase 2; Fatty acyl-CoA elongase; Long-chain fatty-acyl elongase; Very long chain 3-ketoacyl-CoA synthase 6; Very long chain 3-oxoacyl-CoA synthase 6; rELO2", "protein_names_refseq": "3-keto acyl-CoA synthase Elovl6; ELOVL FA elongase 6; ELOVL family member 6, elongation of long chain fatty acids; elongation of very long chain fatty acids protein 6-like; elongation of very long chain fatty acids protein 6; fatty acid elongase 2; fatty acyl-CoA elongase; long-chain fatty-acyl elongase; very long chain 3-ketoacyl-CoA synthase 6; very long chain 3-oxoacyl-CoA synthase 6; very long chain fatty acid elongase 6", "tax_id": 10116, "disease": "", "pathway": " (rno:171402); (R-RNO-75876)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12005057;19429849;20228221;20721682;21266672;27881420", "class_list": "", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, PubMed, PubMed, HAMAP]; Dysregulation of Elovl6-driven long-chain fatty acid metabolism induces phenotypic switching of VSMC via ROS production and AMPK/KLF4 signaling that leads to growth arrest and downregulation of VSMC marker expression. Publication Status: Online-Only, [RefSeq, PubMed]; Gene expressions of ELOVL6 and SPC24 were upregulated, and SERPINA7 was downregulated in the livers of rats with ventromedial hypothalamic lesions., [RefSeq, PubMed]; Increased expression genes encoding Scd1, Elovl6, and other key lipogenic enzymes may favor fat storage after chronic food restriction/refeeding and may be part of the molecular mechanism by which food restriction/refeeding increases body weight, [RefSeq, PubMed]; Overt type 2 diabetes is associated with diminished islet expression of SCD and Elovl6, and this can disrupt desaturation of saturated FAs to MUFAs, rendering beta-cells more susceptible to saturated FA-induced ER stress and apoptosis., [RefSeq, PubMed]; These findings demonstrate that coordinated induction of fatty acid elongases Elovl5 and 6 and desaturase activity is required for balanced synthesis of specific n-7 versus n-9 MUFA species., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" } ], "go_molecular_function": "GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0009923 fatty acid elongase complex", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0030497 fatty acid elongation;GO:0034625 fatty acid elongation, monounsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q920L6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921A4-1", "uniprot_id": [ { "id": "CYGB_RAT", "url": "https://www.uniprot.org/uniprot/Q921A4", "type": "external" } ], "mass": 21497.0, "length": 190, "protein_name": "Cytoglobin", "gene_name": "Cygb", "organism": "Rat", "refseq_name": "cytoglobin", "refseq_ac": [ { "id": "NP_570100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570100", "type": "external" } ], "gene_names_uniprotkb": "Cygb; Stap", "gene_names_refseq": "Cygb; Glnf; Staap; Stap", "protein_names_uniprotkb": "Cytoglobin; 1.11.1.-; 1.14.12.-; 1.15.1.1; 1.7.-.-; Nitric oxygen dioxygenase CYGB; Nitrite reductase CYGB; Pseudoperoxidase CYGB; Stellate cell activation-associated protein; Superoxide dismutase CYGB", "protein_names_refseq": "HGb; cytoglobin; globin f; histoglobin; nitric oxygen dioxygenase CYGB; nitrite reductase CYGB; pseudoperoxidase CYGB; stellate cell activation-associated protein; superoxide dismutase CYGB", "tax_id": 10116, "disease": "renal fibrosis (Disease Ontology:DOID:0050855); chronic pancreatitis (Disease Ontology:DOID:0051065); liver cirrhosis (Disease Ontology:DOID:5082); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:170520); (R-RNO-203615); (R-RNO-8981607)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11320098;14647402;14660570;21224051;23306842;23585565;26312997;28393874;29393594", "class_list": "", "function": "Cygb has a critical role in the regulation of vascular tone and disease. We suggest that modulation of the expression and NOD activity of Cygb represents a strategy for the treatment of cardiovascular disease Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in the healing process of gastric mucosal injuries in the late phase without angiogenesis, [RefSeq, PubMed]; Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability (PubMed:28393874). Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption (PubMed:28393874). By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone (PubMed:28393874). Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress. Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier (By similarity)., [UniProtKB, PubMed, UniProtKB]; The reduction of neonatal HI injury by CYGB may be due in part to antioxidant and antiapoptotic mechanisms and by promoting angiogenesis., [RefSeq, PubMed]; These findings show for the first that Cygb serves as a defensive mechanism against oxidative stress both in vitro and in vivo., [RefSeq, PubMed]; This result suggests that Cygb possibly participates in the development of degenerative diseases; our findings also support the possible biological role of Cygb related to peroxidase activity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" }, { "id": "1.14.12.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016491 oxidoreductase activity;GO:0020037 heme binding;GO:0004096 catalase activity;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0043025 neuronal cell body", "go_biological_process": "GO:0010764 negative regulation of fibroblast migration;GO:0006979 response to oxidative stress;GO:0001666 response to hypoxia;GO:0019395 fatty acid oxidation;GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q921A4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924R9-1", "uniprot_id": [ { "id": "NP1L3_RAT", "url": "https://www.uniprot.org/uniprot/Q924R9", "type": "external" } ], "mass": 60891.0, "length": 536, "protein_name": "Nucleosome assembly protein 1-like 3", "gene_name": "Nap1l3", "organism": "Rat", "refseq_name": "nucleosome assembly protein 1-like 3", "refseq_ac": [ { "id": "NP_596893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596893", "type": "external" } ], "gene_names_uniprotkb": "Nap1l3", "gene_names_refseq": "Nap1l3", "protein_names_uniprotkb": "Nucleosome assembly protein 1-like 3; Histone chaperone NAP1L3", "protein_names_refseq": "histone chaperone NAP1L3; nucleosome assembly protein 1-like 3", "tax_id": 10116, "disease": "", "pathway": " (rno:170914)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone chaperone (By similarity). May play a role in cellular differentiation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q924R9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924S5-1", "uniprot_id": [ { "id": "LONM_RAT", "url": "https://www.uniprot.org/uniprot/Q924S5", "type": "external" } ], "mass": 105793.0, "length": 950, "protein_name": "Lon protease homolog, mitochondrial", "gene_name": "Lonp1", "organism": "Rat", "refseq_name": "lon protease homolog, mitochondrial precursor", "refseq_ac": [ { "id": "NP_596895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596895", "type": "external" } ], "gene_names_uniprotkb": "Lonp1; LONP1; Lon; Prss15", "gene_names_refseq": "Lonp1; Lon; Prss15", "protein_names_uniprotkb": "Lon protease homolog, mitochondrial; 3.4.21.53; 3.6.4.10; LONP; Lon protease-like protein; Mitochondrial ATP-dependent protease Lon; Mitochondrial chaperone LONP1; Serine protease 15", "protein_names_refseq": "LONP; lon protease homolog, mitochondrial precursor; lon protease homolog, mitochondrial; lon protease-like protein; mitochondrial ATP-dependent protease Lon; protease, serine, 15; serine protease 15", "tax_id": 10116, "disease": "CODAS syndrome (Disease Ontology:DOID:0111274); brain ischemia (Disease Ontology:DOID:2316); ischemia (Disease Ontology:DOID:326)", "pathway": " (rno:170916); (R-RNO-9837999)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12082077;12752449;15560797;23858469;30625302;33668863;36064070;7961901", "class_list": "", "function": "ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters., [UniProtKB, HAMAP, UniProtKB, PubMed, PubMed, UniProtKB]; Changes in nuclear gene expression (Lon) triggered by ER stress had the potential to impact important mitochondrial processes such as assembly and/or degradation of cytochrome c oxidase, [RefSeq, PubMed]; LONP1 Regulates Mitochondrial Accumulations of HMGB1 and Caspase-3 in CA1 and PV Neurons Following Status Epilepticus. Publication Status: Online-Only, [RefSeq, PubMed]; LONP1 downregulation with ageing contributes to osteoarthritis via mitochondrial dysfunction., [RefSeq, PubMed]; Lon protease, a major degradation enzyme in mitochondrial matrix, recognized and degraded mitochondrial CBS by specifically targeting at the oxygenated heme group of CBS proteins., [RefSeq, PubMed]; Upregulation of LonP1 mitigates cardiac injury by preventing oxidative damage of proteins and lipids, preserving mitochondrial redox balance and reprogramming bioenergetics by reducing Complex I content and activity. Mechanisms that promote the upregulation of LonP1 could be beneficial in protecting the myocardium from cardiac stress and limiting I/R injury, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0001018 mitochondrial promoter sequence-specific DNA binding;GO:0004252 serine-type endopeptidase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006508 proteolysis;GO:0001666 response to hypoxia;GO:0050730 regulation of peptidyl-tyrosine phosphorylation;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q924S5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924T4-1", "uniprot_id": [ { "id": "LFNG_RAT", "url": "https://www.uniprot.org/uniprot/Q924T4", "type": "external" } ], "mass": 41958.0, "length": 378, "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe", "gene_name": "Lfng", "organism": "Rat", "refseq_name": "beta-1,3-N-acetylglucosaminyltransferase lunatic fringe precursor", "refseq_ac": [ { "id": "NP_596884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596884", "type": "external" } ], "gene_names_uniprotkb": "Lfng", "gene_names_refseq": "Lfng", "protein_names_uniprotkb": "Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "protein_names_refseq": "O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe precursor; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; lunatic fringe gene homolog", "tax_id": 10116, "disease": "spondylocostal dysostosis 3 (Disease Ontology:DOID:0112361)", "pathway": " (rno:170905)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12167404;29393594", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning., [UniProtKB, UniProtKB, UniProtKB]; Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.222", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.222", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0051446 positive regulation of meiotic cell cycle;GO:0045747 positive regulation of Notch signaling pathway;GO:0001756 somitogenesis;GO:0001541 ovarian follicle development;GO:0014807 regulation of somitogenesis", "synthesized_glycan_count": 19, "hit_score": 0.3, "record_id": "Q924T4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99J82-1", "uniprot_id": [ { "id": "ILK_RAT", "url": "https://www.uniprot.org/uniprot/Q99J82", "type": "external" } ], "mass": 51373.0, "length": 452, "protein_name": "Scaffold protein ILK", "gene_name": "Ilk", "organism": "Rat", "refseq_name": "scaffold protein ILK", "refseq_ac": [ { "id": "NP_596900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596900", "type": "external" } ], "gene_names_uniprotkb": "Ilk; ILK1; ILK2", "gene_names_refseq": "ILK-1; ILK-2; Ilk; p59ILK", "protein_names_uniprotkb": "Scaffold protein ILK; ILK-1; ILK-2; Inactive integrin-linked kinase; p59ILK", "protein_names_refseq": "59 kDa serine/threonine-protein kinase; beta-integrin-linked kinase; inactive integrin-linked kinase; integrin-linked protein kinase; scaffold protein ILK", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); dilated cardiomyopathy (Disease Ontology:DOID:12930); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); prostate adenocarcinoma (Disease Ontology:DOID:2526)", "pathway": " (rno:170922); (R-RNO-446343)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11304546;19299337;26520903;27111285;30657569;31255599;34012255", "class_list": "", "function": "Accompanied by the TGF-beta1-induced phenotype change in rat kidney epithelial cell line NRK-52E, both mRNA and protein levels of ILK were upregulated. Overexpression of ILK remarkably stimulated the phenotype change in NRK-52E cells. ILK is upregulated during renal fibrosis. ILK participates in the development of renal fibrosis by altering phenotypes of renal tubular epithelial cells via a TGF-beta1/smad pathway., [RefSeq, PubMed]; Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects on vascular smooth muscle cell proliferation/migration., [RefSeq, PubMed]; ILK initiates the phenotypic transition of pulmonary artery smooth muscle cells., [RefSeq, PubMed]; Investigated the role of ILK in cutaneous wound contraction. We found that ILK was involved in cutaneous wound healing, and ILK and PI3K/AKT inhibitors inhibited wound contraction and re-epithelialization, consequently delaying wound healing in vivo., [RefSeq, PubMed]; PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (By similarity). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (PubMed:19299337). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (By similarity). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (By similarity). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes. Acts as an upstream effector of both AKT1/PKB and GSK3 (By similarity). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (By similarity). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0072697 protein localization to cell cortex;GO:0006468 protein phosphorylation;GO:0007229 integrin-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q99J82-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MH9-1", "uniprot_id": [ { "id": "BBS2_RAT", "url": "https://www.uniprot.org/uniprot/Q99MH9", "type": "external" } ], "mass": 79918.0, "length": 721, "protein_name": "BBSome complex member BBS2", "gene_name": "Bbs2", "organism": "Rat", "refseq_name": "BBSome complex member BBS2", "refseq_ac": [ { "id": "NP_446070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446070", "type": "external" } ], "gene_names_uniprotkb": "Bbs2", "gene_names_refseq": "Bbs2", "protein_names_uniprotkb": "BBSome complex member BBS2; Bardet-Biedl syndrome 2 protein homolog", "protein_names_refseq": "BBSome complex member BBS2; Bardet-Biedl syndrome 2 homolog; bardet-Biedl syndrome 2 protein homolog", "tax_id": 10116, "disease": "Bardet-Biedl syndrome 2 (Disease Ontology:DOID:0110124); retinitis pigmentosa 74 (Disease Ontology:DOID:0110401); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:113948); (R-RNO-5620922)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11285252", "class_list": "", "function": "The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0031514 motile cilium;GO:0043005 neuron projection;GO:0034451 centriolar satellite", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0030534 adult behavior;GO:0021766 hippocampus development;GO:0021987 cerebral cortex development;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99MH9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MZ8-1", "uniprot_id": [ { "id": "LASP1_RAT", "url": "https://www.uniprot.org/uniprot/Q99MZ8", "type": "external" } ], "mass": 29970.0, "length": 263, "protein_name": "LIM and SH3 domain protein 1", "gene_name": "Lasp1", "organism": "Rat", "refseq_name": "LIM and SH3 domain protein 1", "refseq_ac": [ { "id": "NP_116002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116002", "type": "external" } ], "gene_names_uniprotkb": "Lasp1", "gene_names_refseq": "Lasp1", "protein_names_uniprotkb": "LIM and SH3 domain protein 1; LASP-1", "protein_names_refseq": "LASP-1; LIM and SH3 domain protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:29278)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10806114;15372503;19726686;22514729;22673903;29739492;32997597;33144090", "class_list": "", "function": "Binding sites necessary for Krp1-Lasp1 interaction in vitro and function in vivo, [RefSeq, PubMed]; Data indicate that Lasp-1 is a novel component of podosomes and is involved in the regulation of podosomal function., [RefSeq, PubMed]; LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development., [RefSeq, PubMed]; Lasp-1 is strongly expressed by central nervous system neurons and is concentrated at synaptic sites., [RefSeq, PubMed]; Lasp-1 was increased in the uterus at the time of implantation compared with the time of fertilization., [RefSeq, PubMed]; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types., [UniProtKB, PubMed]; Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson's disease via suppression of LASP1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q499R9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0015075 monoatomic ion transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0098794 postsynapse", "go_biological_process": "GO:0006811 monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q99MZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NA7-1", "uniprot_id": [ { "id": "PITX1_RAT", "url": "https://www.uniprot.org/uniprot/Q99NA7", "type": "external" } ], "mass": 34207.0, "length": 315, "protein_name": "Pituitary homeobox 1", "gene_name": "Pitx1", "organism": "Rat", "refseq_name": "pituitary homeobox 1", "refseq_ac": [ { "id": "NP_446076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446076", "type": "external" } ], "gene_names_uniprotkb": "Pitx1; Ptx1", "gene_names_refseq": "Bft; Pitx1", "protein_names_uniprotkb": "Pituitary homeobox 1; Homeobox protein PITX1; Paired-like homeodomain transcription factor 1", "protein_names_refseq": "homeobox protein PITX1; paired-like homeodomain transcription factor 1; pituitary homeobox 1", "tax_id": 10116, "disease": "clubfoot (Disease Ontology:DOID:11836)", "pathway": " (rno:113983)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11250922;25258388;26306672;31527569", "class_list": "", "function": "Orchestrated Egr1 and Pitx1 activities depending on specific central and peripheral regulatory inputs could be responsible for physiologically variable Lhb gene promoter activation in vivo., [RefSeq, PubMed]; Pitx1 binds to the promoter region of SIRT1 and promotes the transcription of SIRT1. Publication Status: Online-Only, [RefSeq, PubMed]; Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb., [UniProtKB, UniProtKB]; This study idnetifed that the PITX1 as inhibitors of neurite outgrowth., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99NA7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPB1-1", "uniprot_id": [ { "id": "DPP2_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPB1", "type": "external" } ], "mass": 55114.0, "length": 500, "protein_name": "Dipeptidyl peptidase 2", "gene_name": "Dpp7", "organism": "Rat", "refseq_name": "dipeptidyl peptidase 2 precursor", "refseq_ac": [ { "id": "NP_114179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114179", "type": "external" } ], "gene_names_uniprotkb": "Dpp7; Dpp2", "gene_names_refseq": "Dpp2; Dpp7", "protein_names_uniprotkb": "Dipeptidyl peptidase 2; 3.4.14.2; DPP II; Dipeptidyl aminopeptidase II; Dipeptidyl peptidase 7; Dipeptidyl peptidase II; Quiescent cell proline dipeptidase", "protein_names_refseq": "DPP II; dipeptidyl aminopeptidase II; dipeptidyl peptidase 2 precursor; dipeptidyl peptidase 2; dipeptidyl peptidase II; quiescent cell proline dipeptidase", "tax_id": 10116, "disease": "", "pathway": " (rno:83799); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11139392;11173530;24090084", "class_list": "", "function": "Plays an important role in the degradation of some oligopeptides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" } ], "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0004177 aminopeptidase activity;GO:0070008 serine-type exopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome;GO:0031410 cytoplasmic vesicle;GO:0031982 vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process;GO:1905146 lysosomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9EPB1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPI2-1", "uniprot_id": [ { "id": "GFRA4_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPI2", "type": "external" } ], "mass": 29682.0, "length": 273, "protein_name": "GDNF family receptor alpha-4", "gene_name": "Gfra4", "organism": "Rat", "refseq_name": "GDNF family receptor alpha-4 isoform 2 precursor", "refseq_ac": [ { "id": "NP_076457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076457", "type": "external" } ], "gene_names_uniprotkb": "Gfra4", "gene_names_refseq": "Gfra4", "protein_names_uniprotkb": "GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; GFR-alpha-4; Persephin receptor", "protein_names_refseq": "GDNF family receptor alpha-4 isoform 2 precursor; GDNF receptor alpha-4; GDNFR-alpha-4; GFR-alpha-4; glial cell line derived neurotrophic factor family receptor alpha 4; persephin receptor", "tax_id": 10116, "disease": "", "pathway": " (rno:66023); (R-RNO-5673001); (R-RNO-8853659)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "10958791", "class_list": "", "function": "Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons (PubMed:10958791). Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor (By similarity). May be important in C-cell development and, in the postnatal development of the adrenal medulla (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9EPI3", "ec_number_list": [], "go_molecular_function": "GO:0016167 glial cell-derived neurotrophic factor receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007399 nervous system development;GO:0030279 negative regulation of ossification;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EPI2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQY6-1", "uniprot_id": [ { "id": "PIGM_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQY6", "type": "external" } ], "mass": 49594.0, "length": 423, "protein_name": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit", "gene_name": "Pigm", "organism": "Rat", "refseq_name": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit", "refseq_ac": [ { "id": "NP_077058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077058", "type": "external" } ], "gene_names_uniprotkb": "Pigm", "gene_names_refseq": "GPI-MT-I; Pigm", "protein_names_uniprotkb": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit; 2.4.1.-; GPI mannosyltransferase I; GPI-MT-I; PIG-M; Phosphatidylinositol-glycan biosynthesis class M protein", "protein_names_refseq": "GPI alpha-1,4-mannosyltransferase I, catalytic subunit; GPI mannosyltransferase 1; GPI mannosyltransferase I; PIG-M mRNA for mannosyltransferase; phosphatidylinositol glycan, class M; phosphatidylinositol-glycan biosynthesis class M protein", "tax_id": 10116, "disease": "", "pathway": " (rno:79112); (R-RNO-162710)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11226175;15635094", "class_list": "glycogene;glycosyltransferase", "function": "Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-alpha-D-glucosaminyl-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl acyl phosphatidylinositol, GlcN-(acyl)PI) intermediate to generate 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0000030 mannosyltransferase activity;GO:0180041 dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1990529 glycosylphosphatidylinositol-mannosyltransferase I complex", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EQY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER24-1", "uniprot_id": [ { "id": "ATX10_RAT", "url": "https://www.uniprot.org/uniprot/Q9ER24", "type": "external" } ], "mass": 53727.0, "length": 475, "protein_name": "Ataxin-10", "gene_name": "Atxn10", "organism": "Rat", "refseq_name": "ataxin-10", "refseq_ac": [ { "id": "NP_579847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579847", "type": "external" } ], "gene_names_uniprotkb": "Atxn10; Sca10", "gene_names_refseq": "Atxn10; Sca10", "protein_names_uniprotkb": "Ataxin-10; Neuronal beta-catenin-like protein; Spinocerebellar ataxia type 10 protein homolog", "protein_names_refseq": "ataxin 10 homolog; ataxin-10; neuronal beta-catenin-like protein; spinocerebellar ataxia 10 homolog; spinocerebellar ataxia type 10 protein homolog", "tax_id": 10116, "disease": "spinocerebellar ataxia 10 (Disease Ontology:DOID:0050960)", "pathway": " (rno:170821)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15201271;16498633;16714295;23462879", "class_list": "", "function": "Findings suggested that Ataxin-10 may be involved in the pathophysiology of sciatic nerve after SNC., [RefSeq, PubMed]; Knock down of SCA10 in primary neuronal cells resulted in an increased apoptosis of cerebellar neurons, [RefSeq, PubMed]; May play a role in the regulation of cytokinesis (By similarity). May play a role in signaling by stimulating protein glycosylation (PubMed:16714295). Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons (PubMed:15201271, PubMed:16498633). Does not appear to play a major role in ciliogenesis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis., [UniProtKB, UniProtKB, UniProtKB]; Neurodegenerative disease protein ataxin-10 (Atx-10) is associated with cytoplasmic O-linked beta-N-acetylglucosamine transferase in in the brain, [RefSeq, PubMed]; Our data suggest that the ataxin 10-Gbeta2 interaction represents a novel mechanism for inducing neuritogenesis in PC12 cells by activating the Ras-MAP kinase-Elk-1 cascade, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007399 nervous system development;GO:0031175 neuron projection development;GO:0051301 cell division;GO:0060271 cilium assembly;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9ER24-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERW3-1", "uniprot_id": [ { "id": "FGF13_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERW3", "type": "external" } ], "mass": 27588.0, "length": 245, "protein_name": "Fibroblast growth factor 13", "gene_name": "Fgf13", "organism": "Rat", "refseq_name": "fibroblast growth factor 13 isoform 4", "refseq_ac": [ { "id": "NP_445880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445880", "type": "external" } ], "gene_names_uniprotkb": "Fgf13", "gene_names_refseq": "FGF-13; Fgf13; Fgf1c", "protein_names_uniprotkb": "Fibroblast growth factor 13; FGF-13", "protein_names_refseq": "fibroblast growth factor 13 isoform 4; fibroblast growth factor 1c", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); developmental and epileptic encephalopathy 90 (Disease Ontology:DOID:0070381); developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:84488)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12244047;15282281;23804213", "class_list": "", "function": "FHF2B is selectively localized at nodes of dorsal root sensory but not ventral root motor axons. This may provide a basis for physiological differences in Na currents that have been reported at the nodes of Ranvier in sensory versus motor axons., [RefSeq, PubMed]; Fibroblast growth factor homologous factors (FGF11-14) modulate cardiac calcium channels., [RefSeq, PubMed]; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). Regulates voltage-gated sodium channel transport and function (By similarity). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008083 growth factor activity;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0048755 branching morphogenesis of a nerve;GO:0007611 learning or memory;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9ERW3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHU0-1", "uniprot_id": [ { "id": "DPYL5_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHU0", "type": "external" } ], "mass": 61540.0, "length": 564, "protein_name": "Dihydropyrimidinase-related protein 5", "gene_name": "Dpysl5", "organism": "Rat", "refseq_name": "dihydropyrimidinase-related protein 5", "refseq_ac": [ { "id": "NP_075412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075412", "type": "external" } ], "gene_names_uniprotkb": "Dpysl5; Ulip6", "gene_names_refseq": "Crmp5; Dpysl5; Ulip6", "protein_names_uniprotkb": "Dihydropyrimidinase-related protein 5; DRP-5; ULIP-6; UNC33-like phosphoprotein 6", "protein_names_refseq": "DRP-5; ULIP-6; UNC33-like phosphoprotein 6; dihydropyrimidinase-related protein 5-like; dihydropyrimidinase-related protein 5", "tax_id": 10116, "disease": "Ritscher-Schinzel syndrome (Disease Ontology:DOID:0060565)", "pathway": " (rno:65208); (R-RNO-399956)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11034345;18683930;19805073;26677106", "class_list": "", "function": "CRMP5 is able to interact with the actin cytoskeleton network in the growth cone and affect growth cone development and neurite outgrowth via this interaction in developing hippocampal neurons., [RefSeq, PubMed]; Involved in the negative regulation of dendrite outgrowth., [UniProtKB, UniProtKB]; Results provide marker proteins Gap-43 and newly identified candidate neuronal growth-associated proteins MAP1B, CRMP5, crmp5 and catenins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050774 negative regulation of dendrite morphogenesis;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JHU0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JII9-1", "uniprot_id": [ { "id": "CXCR3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JII9", "type": "external" } ], "mass": 40935.0, "length": 367, "protein_name": "C-X-C chemokine receptor type 3", "gene_name": "Cxcr3", "organism": "Rat", "refseq_name": "C-X-C chemokine receptor type 3", "refseq_ac": [ { "id": "NP_445867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445867", "type": "external" } ], "gene_names_uniprotkb": "Cxcr3", "gene_names_refseq": "Cxcr3; Gpr9", "protein_names_uniprotkb": "C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; IP-10 receptor; Interferon-inducible protein 10 receptor", "protein_names_refseq": "C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; G protein-coupled receptor 9; IP-10 receptor; chemokine (C-X-C motif) receptor 3; interferon-inducible protein 10 receptor", "tax_id": 10116, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); dilated cardiomyopathy (Disease Ontology:DOID:12930); pulmonary sarcoidosis (Disease Ontology:DOID:13406); thoracic aortic aneurysm (Disease Ontology:DOID:14004); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); asthma (Disease Ontology:DOID:2841); high grade glioma (Disease Ontology:DOID:3070); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); middle cerebral artery infarction (Disease Ontology:DOID:3525); systemic scleroderma (Disease Ontology:DOID:418); coronary restenosis (Disease Ontology:DOID:4247); myasthenia gravis (Disease Ontology:DOID:437); rheumatoid arthritis (Disease Ontology:DOID:7148); myocarditis (Disease Ontology:DOID:820); extrinsic allergic alveolitis (Disease Ontology:DOID:841); ulcerative colitis (Disease Ontology:DOID:8577); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:84475); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10825390;26572542;26835911;28046003;30448292;32782146", "class_list": "", "function": "CXCR3 contributes to neuropathic pain via ERK activation in the anterior cingulate cortex., [RefSeq, PubMed]; Chemokine CXCL10 promotes the development of experimental acute respiratory distress syndrome by binding to its receptor CXCR3 Publication Status: Online-Only, [RefSeq, PubMed]; Dats show that CXCL10 chemokine treatment promoted the activation of p38 MAPK pathway through CXCR3 receptor signaling, thereby up-regulating focal adhesion kinase (FAK) activation and promoted cardiac microvascular endothelial cell migration., [RefSeq, PubMed]; Receptor for the C-X-C chemokines CXCL9, CXCL10 and CXCL11, and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G protein signaling pathway. Probably promotes cell chemotaxis response (By similarity). Receptor for chemokine CCL21. Upon activation by PF4, induces activated T-lymphocyte migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Study showed that CXCL10 and CXCR3 expression was induced predominantly in activated neurons after chronic constriction injury. And, it is likely that CXCL10/CXCR3 participates in neuropathic pain via the p-ERK pathway., [RefSeq, PubMed]; The present study leads to an assumption that CXCL10/CXCR3 signaling mediates inhibition of the corticotropin-releasing factor-stimulated adrenocorticotropin-release by interferon-gamma., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0016494 C-X-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0019958 C-X-C chemokine binding;GO:0019956 chemokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JII9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIX3-1", "uniprot_id": [ { "id": "FHIT_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIX3", "type": "external" } ], "mass": 17348.0, "length": 150, "protein_name": "Bis(5'-adenosyl)-triphosphatase", "gene_name": "Fhit", "organism": "Rat", "refseq_name": "bis(5'-adenosyl)-triphosphatase isoform 1", "refseq_ac": [ { "id": "NP_068542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068542", "type": "external" } ], "gene_names_uniprotkb": "Fhit", "gene_names_refseq": "Fhit", "protein_names_uniprotkb": "Bis(5'-adenosyl)-triphosphatase; 2.7.7.51; 3.6.1.29; 3.6.2.1; 3.9.1.-; AP3A hydrolase; AP3Aase; Adenosine 5'-monophosphoramidase FHIT; Adenylylsulfatase; Adenylylsulfate-ammonia adenylyltransferase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein", "protein_names_refseq": "AP3A hydrolase; AP3Aase; adenosine 5'-monophosphoramidase FHIT; adenylylsulfatase; adenylylsulfate-ammonia adenylyltransferase; bis(5'-adenosyl)-triphosphatase isoform 1; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase; dinucleosidetriphosphatase; fragile histidine triad protein", "tax_id": 10116, "disease": "Muir-Torre syndrome (Disease Ontology:DOID:0050465); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); squamous cell carcinoma (Disease Ontology:DOID:1749); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); lung non-small cell carcinoma (Disease Ontology:DOID:3908); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:60398)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36637791", "class_list": "", "function": "CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain., [RefSeq, PubMed]; Possesses dinucleoside triphosphate hydrolase activity (By similarity). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (By similarity). Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (By similarity). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (By similarity). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (By similarity). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (By similarity). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (By similarity). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (By similarity). Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (By similarity). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity) Functions as a tumor suppressor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "2.7.7.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51", "type": "external" }, { "id": "3.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0031625 ubiquitin protein ligase binding;GO:0016151 nickel cation binding;GO:0047710 bis(5'-adenosyl)-triphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0015964 diadenosine triphosphate catabolic process;GO:0006351 DNA-templated transcription;GO:0006260 DNA replication;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JIX3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJW3-1", "uniprot_id": [ { "id": "ATPMK_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJW3", "type": "external" } ], "mass": 6408.0, "length": 58, "protein_name": "ATP synthase F(0) complex subunit k, mitochondrial", "gene_name": "Atp5mk", "organism": "Rat", "refseq_name": "ATP synthase F(0) complex subunit k, mitochondrial", "refseq_ac": [ { "id": "NP_598228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598228", "type": "external" } ], "gene_names_uniprotkb": "Atp5mk; Atp5md; Dapit; Usmg5", "gene_names_refseq": "Atp5md; Atp5mk; Dapit; Usmg5", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit k, mitochondrial; ATP synthase membrane subunit DAPIT, mitochondrial; Diabetes-associated protein in insulin-sensitive tissues; Up-regulated during skeletal muscle growth protein 5", "protein_names_refseq": "ATP synthase F(0) complex subunit k, mitochondrial; ATP synthase membrane subunit DAPIT, mitochondrial; ATP synthase membrane subunit K, mitochondrial; diabetes-associated protein in insulin-sensitive tissues; up-regulated during skeletal muscle growth 5 homolog; up-regulated during skeletal muscle growth protein 5; upregulated during skeletal muscle growth 5", "tax_id": 10116, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 6 (Disease Ontology:DOID:0111749)", "pathway": " (rno:171069); (R-RNO-163210); (R-RNO-8949613)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11757806;17575325;22688299", "class_list": "", "function": "Confirm the mitochondrial presence of DAPIT on cellular level. We also show that DAPIT is localized in lysosomes of HUVEC and HEK 293T cells Publication Status: Online-Only, [RefSeq, PubMed]; Down-regulated in insulin-sensitive tissues (skeletal muscle, myocardium)in streptozotocin-induced diabetes, [RefSeq, PubMed]; Subunit k, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (By similarity). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (By similarity). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Required for dimerization of the ATP synthase complex and as such regulates ATP synthesis in the mitochondria (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JJW3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJZ1-1", "uniprot_id": [ { "id": "SL2A8_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJZ1", "type": "external" } ], "mass": 51459.0, "length": 478, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 8", "gene_name": "Slc2a8", "organism": "Rat", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 8 isoform 1", "refseq_ac": [ { "id": "NP_445946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445946", "type": "external" } ], "gene_names_uniprotkb": "Slc2a8; Glut8; Glutx1", "gene_names_refseq": "Glut8; Slc2a8", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 8; GLUT-8; Glucose transporter type 8; Glucose transporter type X1", "protein_names_refseq": "GLUT-8; glucose transporter type 8; glucose transporter type X1; solute carrier family 2, (facilitated glucose transporter) member 8; solute carrier family 2, facilitated glucose transporter member 8 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:85256); (R-RNO-189200); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10671487;10821868;16109784;19194835;23396969;24382486", "class_list": "", "function": "Hippocampal mRNA abundance of GLUT8 decreases with age in males and females, [RefSeq, PubMed]; In cells normally expressing it, GLUT8 was associated with a specific intracellular compartment in which it may play an as-yet-uncharacterized role., [RefSeq, PubMed]; Insulin depletion and hyperglycemia do not regulate the expression of GLUT8 in testes., [RefSeq, PubMed]; Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:10671487). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate (PubMed:23396969)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JMA6", "ec_number_list": [], "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0005536 D-glucose binding;GO:0055056 D-glucose transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0001666 response to hypoxia;GO:0008286 insulin receptor signaling pathway;GO:0015755 fructose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJZ1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWE9-1", "uniprot_id": [ { "id": "GGT5_RAT", "url": "https://www.uniprot.org/uniprot/Q9QWE9", "type": "external" } ], "mass": 61569.0, "length": 572, "protein_name": "Glutathione hydrolase 5 proenzyme", "gene_name": "Ggt5", "organism": "Rat", "refseq_name": "glutathione hydrolase 5 proenzyme", "refseq_ac": [ { "id": "NP_062108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062108", "type": "external" } ], "gene_names_uniprotkb": "Ggt5; Ggtla1", "gene_names_refseq": "Ggt5; Ggta1; Ggtla1", "protein_names_uniprotkb": "Glutathione hydrolase 5 proenzyme; 2.3.2.2; 3.4.19.13; 3.4.19.14; GGL; GGT 5; GGT-rel; Gamma-glutamyl leukotrienase; Gamma-glutamyl transpeptidase-related enzyme; Gamma-glutamyltransferase 5; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Leukotriene-C4 hydrolase", "protein_names_refseq": "GGL; GGT 5; GGT-rel; gamma-glutamyl leukotrienase; gamma-glutamyl transpeptidase-related enzyme; gamma-glutamyltransferase-like activity 1; gamma-glutamyltranspeptidase 5; glutathione hydrolase 5 proenzyme; leukotriene-C4 hydrolase", "tax_id": 10116, "disease": "", "pathway": " (rno:29566); (R-RNO-174403); (R-RNO-2142691); (R-RNO-5423646); (R-RNO-9753281)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "9374738", "class_list": "", "function": "Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates (By similarity). Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis (By similarity). Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine. Converts extracellular LTC4 to LTD4 during acute inflammatory response. Acts as a negative regulator of GGG bioactivity. GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to bone marrow parenchyma (By similarity). The transpeptidation reaction, i.e. the transfer of gamma-glutamyl moiety to an acceptor molecule to yield a new gamma-glutamyl compound requires high concentration of dipeptide acceptor and is considered nonphysiological (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q5PQV0", "ec_number_list": [ { "id": "2.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.2", "type": "external" }, { "id": "3.4.19.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.13", "type": "external" }, { "id": "3.4.19.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.14", "type": "external" } ], "go_molecular_function": "GO:0000048 peptidyltransferase activity;GO:0002951 leukotriene-C(4) hydrolase;GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0006751 glutathione catabolic process;GO:0006508 proteolysis;GO:0006631 fatty acid metabolic process;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QWE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXS4-1", "uniprot_id": [ { "id": "NT8F3_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXS4", "type": "external" } ], "mass": 26038.0, "length": 228, "protein_name": "N-acetyltransferase family 8 member 3", "gene_name": "Nat8f3", "organism": "Rat", "refseq_name": "N-acetyltransferase family 8 member 3", "refseq_ac": [ { "id": "NP_543159", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543159", "type": "external" } ], "gene_names_uniprotkb": "Nat8f3; Cml3", "gene_names_refseq": "Nat8f3", "protein_names_uniprotkb": "N-acetyltransferase family 8 member 3; 2.3.1.48; Camello-like protein 3; N-acetyltransferase CML3", "protein_names_refseq": "N-acetyltransferase family 8 member 3; camello-like 3; camello-like protein 3; probable N-acetyltransferase CML3", "tax_id": 10116, "disease": "", "pathway": " (rno:113892)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11397015", "class_list": "", "function": "Has histone acetyltransferase activity in vitro, with specificity for histone H4., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0010485 histone H4 acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001702 gastrulation with mouth forming second", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QXS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXY4-1", "uniprot_id": [ { "id": "OGFR_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXY4", "type": "external" } ], "mass": 64728.0, "length": 580, "protein_name": "Opioid growth factor receptor", "gene_name": "Ogfr", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ogfr", "gene_names_refseq": "", "protein_names_uniprotkb": "Opioid growth factor receptor; OGFr; Zeta-type opioid receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10592296;11890982;22673903", "class_list": "", "function": "Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140625 opioid growth factor receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QXY4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYN5-1", "uniprot_id": [ { "id": "BCL10_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYN5", "type": "external" } ], "mass": 25999.0, "length": 233, "protein_name": "B-cell lymphoma/leukemia 10", "gene_name": "Bcl10", "organism": "Rat", "refseq_name": "B-cell lymphoma/leukemia 10", "refseq_ac": [ { "id": "NP_112618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112618", "type": "external" } ], "gene_names_uniprotkb": "Bcl10", "gene_names_refseq": "Bcl10", "protein_names_uniprotkb": "B-cell lymphoma/leukemia 10; B-cell CLL/lymphoma 10; Bcl-10; R-RCD1; RCD", "protein_names_refseq": "B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; R-RCD1; RCD; bcl-10", "tax_id": 10116, "disease": "extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Disease Ontology:DOID:0050909); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); immunodeficiency 37 (Disease Ontology:DOID:0111939); malignant mesothelioma (Disease Ontology:DOID:1790)", "pathway": " (rno:83477); (R-RNO-1169091); (R-RNO-202424); (R-RNO-2871837); (R-RNO-5607764); (R-RNO-8866654)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "10753917", "class_list": "", "function": "Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex. This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity. Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0002020 protease binding;GO:0003713 transcription coactivator activity;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045121 membrane raft;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0006968 cellular defense response;GO:0032094 response to food", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QYN5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYP2-1", "uniprot_id": [ { "id": "CELR2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYP2", "type": "external" } ], "mass": 233481.0, "length": 2144, "protein_name": "Cadherin EGF LAG seven-pass G-type receptor 2", "gene_name": "Celsr2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Celsr2; Megf3", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin EGF LAG seven-pass G-type receptor 2; Multiple EGF-like domains protein 3; Multiple epidermal growth factor-like domains protein 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "22673903;24090084;38843836;9693030", "class_list": "", "function": "Receptor that may have an important role in cell/cell signaling during nervous system formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 13, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 1, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0001764 neuron migration;GO:0006355 regulation of DNA-templated transcription;GO:0022407 regulation of cell-cell adhesion;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9QYP2-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R011-1", "uniprot_id": [ { "id": "PLK3_RAT", "url": "https://www.uniprot.org/uniprot/Q9R011", "type": "external" } ], "mass": 71768.0, "length": 647, "protein_name": "Serine/threonine-protein kinase PLK3", "gene_name": "Plk3", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase PLK3", "refseq_ac": [ { "id": "NP_071523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071523", "type": "external" } ], "gene_names_uniprotkb": "Plk3; Cnk; Fnk", "gene_names_refseq": "Cnk; Fnk; Plk3", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK3; 2.7.11.21; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; PLK-3; Polo-like kinase 3", "protein_names_refseq": "FGF-inducible kinase; PLK-3; cytokine inducible kinase; cytokine-inducible serine/threonine-protein kinase; serine-threonine kinase; serine/threonine-protein kinase PLK3", "tax_id": 10116, "disease": "ovary epithelial cancer (Disease Ontology:DOID:2152); breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (rno:58936); (R-RNO-6804115); (R-RNO-6804756); (R-RNO-69601)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10523297;22870256;38906226", "class_list": "", "function": "PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1 (By similarity)., [UniProtKB]; The increase in Plk2 and Plk3 expression contributes to the cell cycle arrest of granulosa cells which is important for the luteinization of granulosa cells during the periovulatory period. Erratum:[PLoS One. 2012;7(8): doi/10.1371/annotation/1a9779fe-f0ab-4937-a3ce-1bc7fb0268df], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0002039 p53 binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0044819 mitotic G1/S transition checkpoint signaling;GO:1904716 positive regulation of chaperone-mediated autophagy;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0006970 response to osmotic stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9R011-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R066-1", "uniprot_id": [ { "id": "CXAR_RAT", "url": "https://www.uniprot.org/uniprot/Q9R066", "type": "external" } ], "mass": 39949.0, "length": 365, "protein_name": "Coxsackievirus and adenovirus receptor homolog", "gene_name": "Cxadr", "organism": "Rat", "refseq_name": "coxsackievirus and adenovirus receptor homolog isoform 2 precursor", "refseq_ac": [ { "id": "NP_446022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446022", "type": "external" } ], "gene_names_uniprotkb": "Cxadr; Car", "gene_names_refseq": "Car1; Cxadr", "protein_names_uniprotkb": "Coxsackievirus and adenovirus receptor homolog; CAR; rCAR", "protein_names_refseq": "CAR; CXADR, Ig-like cell adhesion molecule; coxsackie virus and adenovirus receptor; coxsackievirus and adenovirus receptor homolog isoform 2 precursor; coxsackievirus and adenovirus receptor homolog; rCAR", "tax_id": 10116, "disease": "", "pathway": " (rno:89843); (R-RNO-198933); (R-RNO-202733)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10490761;22673903;22875787;24057874;25497012;38843836", "class_list": "", "function": "CAR is not only a structural protein: it is involved in conferring the phosphorylation status of other adhesion proteins at the blood-testis barrier., [RefSeq, PubMed]; CAR-positive cells are pituitary stem/progenitor cells and compose putative stem/progenitor cell niches in the MCL and parenchyma., [RefSeq, PubMed]; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair (By similarity)., [UniProtKB]; Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5M817;Q9R067", "ec_number_list": [], "go_molecular_function": "GO:0071253 connexin binding;GO:0005102 signaling receptor binding;GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0007507 heart development;GO:0051607 defense response to virus;GO:0030036 actin cytoskeleton organization;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9R066-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0J8-1", "uniprot_id": [ { "id": "LGMN_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0J8", "type": "external" } ], "mass": 49466.0, "length": 435, "protein_name": "Legumain", "gene_name": "Lgmn", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lgmn; Prsc1", "gene_names_refseq": "", "protein_names_uniprotkb": "Legumain; 3.4.22.34; Asparaginyl endopeptidase; Protease, cysteine 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "lymphatic system disease (Disease Ontology:DOID:75)", "pathway": " (rno:63865); (R-RNO-1679131); (R-RNO-196791); (R-RNO-2132295)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9742219", "class_list": "", "function": "Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9JLN3", "ec_number_list": [ { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.22.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.34", "type": "external" } ], "go_molecular_function": "GO:0008233 peptidase activity;GO:0061133 endopeptidase activator activity;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0045177 apical part of cell;GO:0048471 perinuclear region of cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0006508 proteolysis;GO:0007613 memory;GO:0008284 positive regulation of cell population proliferation;GO:0008306 associative learning", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9R0J8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTV1-1", "uniprot_id": [ { "id": "CH3L1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTV1", "type": "external" } ], "mass": 42392.0, "length": 381, "protein_name": "Chitinase-3-like protein 1", "gene_name": "Chi3l1", "organism": "Rat", "refseq_name": "chitinase-3-like protein 1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001296749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001296749", "type": "external" } ], "gene_names_uniprotkb": "Chi3l1", "gene_names_refseq": "CGP-39; Chi3l1; Chil1; GP-39; YKL-40; YKL40", "protein_names_uniprotkb": "Chitinase-3-like protein 1; CGP-39; Cartilage glycoprotein 39; GP-39", "protein_names_refseq": "cartilage glycoprotein 39; chitinase 3-like 1 (cartilage glycoprotein-39); chitinase 3-like 1 protein; chitinase-3-like protein 1 isoform 1 precursor; chitinase-3-like protein 1", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); small cell carcinoma (Disease Ontology:DOID:0050685); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate carcinoma (Disease Ontology:DOID:10286); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); temporal arteritis (Disease Ontology:DOID:13375); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); chondrosarcoma (Disease Ontology:DOID:3371); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); neuromyelitis optica (Disease Ontology:DOID:8869); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:89824); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "33744763;34168643;38634621", "class_list": "glycogene;glycosylhydrolase", "function": "Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity)., [UniProtKB]; Effects of chitinase-3-like protein 1 on brain death-induced hepatocyte apoptosis via PAR2-JNK-caspase-3., [RefSeq, PubMed]; M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Ralpha2/MAPK Pathway in Rat Intervertebral Disc Degeneration. Publication Status: Online-Only, [RefSeq, PubMed]; YKL-40 Knockdown Decreases Oxidative Stress Damage in Ovarian Granulosa Cells., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 2, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5BJR6", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0010800 positive regulation of peptidyl-threonine phosphorylation;GO:0034612 response to tumor necrosis factor;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WTV1-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVH8-1", "uniprot_id": [ { "id": "FBLN5_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVH8", "type": "external" } ], "mass": 50160.0, "length": 448, "protein_name": "Fibulin-5", "gene_name": "Fbln5", "organism": "Rat", "refseq_name": "fibulin-5 precursor", "refseq_ac": [ { "id": "NP_062026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062026", "type": "external" } ], "gene_names_uniprotkb": "Fbln5; Dance", "gene_names_refseq": "Fbln5", "protein_names_uniprotkb": "Fibulin-5; Dance; Developmental arteries and neural crest EGF-like protein; EVEC; Embryonic vascular EGF repeat-containing protein; FIBL-5", "protein_names_refseq": "EVEC; FIBL-5; dance; developmental arteries and neural crest EGF-like protein; embryonic vascular EGF repeat-containing protein; fibulin-5 precursor", "tax_id": 10116, "disease": "autosomal recessive cutis laxa type IA (Disease Ontology:DOID:0070135); autosomal dominant cutis laxa 2 (Disease Ontology:DOID:0070136); aromatase excess syndrome (Disease Ontology:DOID:0090122); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); age related macular degeneration (Disease Ontology:DOID:10871); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); protein-energy malnutrition (Disease Ontology:DOID:11801); urethral obstruction (Disease Ontology:DOID:12577); Sjogren's syndrome (Disease Ontology:DOID:12894); endometrial cancer (Disease Ontology:DOID:1380); bladder neck obstruction (Disease Ontology:DOID:13948); hypothyroidism (Disease Ontology:DOID:1459); prostatitis (Disease Ontology:DOID:14654); breast cancer (Disease Ontology:DOID:1612); disorder of sexual development (Disease Ontology:DOID:1923); ovarian cancer (Disease Ontology:DOID:2394); endometriosis (Disease Ontology:DOID:289); cutis laxa (Disease Ontology:DOID:3144); placental insufficiency (Disease Ontology:DOID:3891); esophagus adenocarcinoma (Disease Ontology:DOID:4914); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:29158); (R-RNO-1566948); (R-RNO-2129379)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10347091;10428823;26021746;28251683;32286390", "class_list": "", "function": "Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Fibulin-5 overexpression attenuated reactive oxygen species expression, which in turn decreased apoptosis and blood-brain barrier (BBB) permeability following middle cerebral artery occlusion and reperfusion., [RefSeq, PubMed]; Protease Inhibition Improves Healing of The Vaginal Wall after Obstetrical Injury: Results from a Preclinical Animal Model. Publication Status: Online-Only, [RefSeq, PubMed]; Upregulation of fibulin-5 is involved in the beneficial effect of RIPostC against cerebral I/R injury, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9R284", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0071953 elastic fiber", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WVH8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z217-1", "uniprot_id": [ { "id": "GDF11_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z217", "type": "external" } ], "mass": 44921.0, "length": 405, "protein_name": "Growth/differentiation factor 11", "gene_name": "Gdf11", "organism": "Rat", "refseq_name": "growth/differentiation factor 11 precursor", "refseq_ac": [ { "id": "NP_058899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058899", "type": "external" } ], "gene_names_uniprotkb": "Gdf11; Bmp11", "gene_names_refseq": "BMP-11; Gdf11", "protein_names_uniprotkb": "Growth/differentiation factor 11; BMP-11; Bone morphogenetic protein 11; GDF-11", "protein_names_refseq": "GDF-11; bone morphogenetic protein 11; growth/differentiation factor 11 precursor", "tax_id": 10116, "disease": "Perrault syndrome 7 (Disease Ontology:DOID:0061073); vertebral hypersegmentation and orofacial anomalies (Disease Ontology:DOID:0070418)", "pathway": " (rno:29454)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10072786;35461108;36293138;36749472;37220327;37827256", "class_list": "", "function": "Effect of growth differentiation factor 11 expression after peripheral nerve injury in Sprague-Dawley rats., [RefSeq, PubMed]; GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFbetaR1/SMAD-2 pathway., [RefSeq, PubMed]; GDF11 mediates H2S to prevent chronic stress-induced cognitive impairment by reducing hippocampal NLRP3/caspase-1-dependent pyroptosis., [RefSeq, PubMed]; GDF11, a target of miR-32-5p, suppresses high-glucose-induced mitochondrial dysfunction and apoptosis in HK-2 cells through PI3K/AKT signaling activation., [RefSeq, PubMed]; Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "G3V6Y2", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045665 negative regulation of neuron differentiation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0001501 skeletal system development;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z217-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z252-1", "uniprot_id": [ { "id": "LIN7B_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z252", "type": "external" } ], "mass": 22900.0, "length": 207, "protein_name": "Protein lin-7 homolog B", "gene_name": "Lin7b", "organism": "Rat", "refseq_name": "protein lin-7 homolog B", "refseq_ac": [ { "id": "NP_068526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068526", "type": "external" } ], "gene_names_uniprotkb": "Lin7b; Mals2; Veli1a; Veli2", "gene_names_refseq": "Lin7b; MALS2; Veli1a; Veli2", "protein_names_uniprotkb": "Protein lin-7 homolog B; Lin-7B; MALS-2; Mammalian lin-seven protein 2; Veli-2; Vertebrate lin-7 homolog 2", "protein_names_refseq": "MALS-2; lin 7 homolog b; lin-7 homolog B, crumbs cell polarity complex component; lin-7-A; lin-7B; mammalian lin-seven protein 2; protein lin-7 homolog B; veli-2 protein; vertebrate homolog of C. elegans Lin-7 type 2; vertebrate lin-7 homolog 2", "tax_id": 10116, "disease": "", "pathway": " (rno:60377); (R-RNO-212676); (R-RNO-5666185)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10341223;10362251;12040031;12393911;14960569;15494546;9753324", "class_list": "", "function": "Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity)., [UniProtKB, UniProtKB, PubMed]; Specific Veli isoforms participate in forming distinct protein complexes in brain, where Veli-1 stably associates with CASK and SAP97, Veli-2 associates with CASK and Mint1, and Veli-3 associates with CASK, SAP97, and Mint1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0016323 basolateral plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0015031 protein transport;GO:0007043 cell-cell junction assembly;GO:0007269 neurotransmitter secretion;GO:0006887 exocytosis;GO:0048489 synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z252-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z254-1", "uniprot_id": [ { "id": "GIPC1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z254", "type": "external" } ], "mass": 36133.0, "length": 333, "protein_name": "PDZ domain-containing protein GIPC1", "gene_name": "Gipc1", "organism": "Rat", "refseq_name": "PDZ domain-containing protein GIPC1", "refseq_ac": [ { "id": "NP_445793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445793", "type": "external" } ], "gene_names_uniprotkb": "Gipc1; Gipc; Rgs19ip1", "gene_names_refseq": "Gipc1; Gipc; Rgs19ip1; Rgs19", "protein_names_uniprotkb": "PDZ domain-containing protein GIPC1; GAIP C-terminus-interacting protein; GLUT1 C-terminal-binding protein; GLUT1CBP; RGS-GAIP-interacting protein; RGS19-interacting protein 1; Synectin", "protein_names_refseq": "GAIP C-terminus-interacting protein; GLUT1 C-terminal-binding protein; GLUT1CBP; PDZ domain-containing protein GIPC1; RGS-GAIP interacting protein, C-terminus; RGS-GAIP-interacting protein; RGS19-interacting protein 1; regulator of G-protein signaling 19 interacting protein 1; synectin", "tax_id": 10116, "disease": "oculopharyngodistal myopathy 2 (Disease Ontology:DOID:0081298); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:83823); (R-RNO-190370); (R-RNO-190373); (R-RNO-9839389); (R-RNO-9839397)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10198040;16467373;22673903;9770488", "class_list": "", "function": "May be involved in G protein-linked signaling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6GR70;Q9QUQ4", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0017022 myosin binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005903 brush border;GO:0005938 cell cortex", "go_biological_process": "GO:0006605 protein targeting;GO:0007268 chemical synaptic transmission;GO:0048167 regulation of synaptic plasticity;GO:0031647 regulation of protein stability;GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z254-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2H4-1", "uniprot_id": [ { "id": "LGR4_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2H4", "type": "external" } ], "mass": 104241.0, "length": 951, "protein_name": "Leucine-rich repeat-containing G protein-coupled receptor 4", "gene_name": "Lgr4", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing G-protein coupled receptor 4 precursor", "refseq_ac": [ { "id": "NP_775450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775450", "type": "external" } ], "gene_names_uniprotkb": "Lgr4; Gpr48", "gene_names_refseq": "Gpr48; Lgr4", "protein_names_uniprotkb": "Leucine-rich repeat-containing G protein-coupled receptor 4; G protein-coupled receptor 48", "protein_names_refseq": "G-protein coupled receptor 48; leucine-rich repeat-containing G-protein coupled receptor 4 precursor", "tax_id": 10116, "disease": "glaucoma (Disease Ontology:DOID:1686)", "pathway": " (rno:286994)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21454685;24280058;25188337;35772369;9849958", "class_list": "", "function": "Low levels of cadmium exposure affect bone by inhibiting Lgr4 expression in osteoblasts and osteoclasts., [RefSeq, PubMed]; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP. Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin-mediated Lgr4-Wnt signaling during gonadal development. Publication Status: Online-Only, [RefSeq, PubMed]; These data indicate that Rspo1 and Rspo3 and their receptor LGR4 form novel circuits in the brain to regulate energy homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "G3V6R1", "ec_number_list": [], "go_molecular_function": "GO:0016500 protein-hormone receptor activity;GO:0004888 transmembrane signaling receptor activity;GO:0008201 heparin binding;GO:0048495 Roundabout binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007283 spermatogenesis;GO:0045087 innate immune response;GO:0007623 circadian rhythm;GO:0046849 bone remodeling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z2H4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2N5-1", "uniprot_id": [ { "id": "NXPH3_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2N5", "type": "external" } ], "mass": 28225.0, "length": 252, "protein_name": "Neurexophilin-3", "gene_name": "Nxph3", "organism": "Rat", "refseq_name": "neurexophilin-3 precursor", "refseq_ac": [ { "id": "NP_067711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067711", "type": "external" } ], "gene_names_uniprotkb": "Nxph3; Nph3", "gene_names_refseq": "Nph3; Nxph3", "protein_names_uniprotkb": "Neurexophilin-3", "protein_names_refseq": "neurexophilin-3 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:59315)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9570794", "class_list": "", "function": "May be signaling molecules that resemble neuropeptides., [UniProtKB, UniProtKB]; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z2N5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZDX9-1", "uniprot_id": [ { "id": "MCIN_RAT", "url": "https://www.uniprot.org/uniprot/D3ZDX9", "type": "external" } ], "mass": 41162.0, "length": 379, "protein_name": "Multicilin", "gene_name": "Mcidas", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mcidas; Idas; Mcin; Mci", "gene_names_refseq": "", "protein_names_uniprotkb": "Multicilin; McIdas protein; Multiciliate differentiation and DNA synthesis-associated cell cycle protein; Protein Idas", "protein_names_refseq": "", "tax_id": 10116, "disease": "primary ciliary dyskinesia 42 (Disease Ontology:DOID:0111855)", "pathway": " (rno:688802)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4AE60", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:1903251 multi-ciliated epithelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZDX9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPN6-1", "uniprot_id": [ { "id": "D3ZPN6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPN6", "type": "external" } ], "mass": 21540.0, "length": 190, "protein_name": "C-type lectin domain family 5 member A", "gene_name": "Clec5a", "organism": "Rat", "refseq_name": "C-type lectin domain family 5 member A isoform 1", "refseq_ac": [ { "id": "NP_001102847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102847", "type": "external" } ], "gene_names_uniprotkb": "Clec5a", "gene_names_refseq": "Clec5a", "protein_names_uniprotkb": "C-type lectin domain family 5 member A; C-type lectin superfamily member 5; Myeloid DAP12-associating lectin 1", "protein_names_refseq": "C-type lectin domain family 5 member A isoform 1; C-type lectin domain family 5, member A", "tax_id": 10116, "disease": "", "pathway": " (rno:679787); (R-RNO-2172127); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "39187376", "class_list": "", "function": "CLEC5A Promotes Neuronal Pyroptosis in Rat Spinal Cord Injury Models by Interacting with TREM1 and Elevating NLRC4 Expression. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0045087 innate immune response;GO:0043066 negative regulation of apoptotic process;GO:0001819 positive regulation of cytokine production;GO:0002076 osteoblast development;GO:0033033 negative regulation of myeloid cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZPN6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JVD9-1", "uniprot_id": [ { "id": "A0A0G2JVD9_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JVD9", "type": "external" } ], "mass": 62051.0, "length": 562, "protein_name": "IKAROS family zinc finger 1", "gene_name": "Ikzf1", "organism": "Rat", "refseq_name": "DNA-binding protein Ikaros isoform X1", "refseq_ac": [ { "id": "XP_006251556", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006251556", "type": "external" } ], "gene_names_uniprotkb": "Ikzf1", "gene_names_refseq": "Ikzf1; RGD1562979", "protein_names_uniprotkb": "IKAROS family zinc finger 1", "protein_names_refseq": "DNA-binding protein Ikaros isoform X1", "tax_id": 10116, "disease": "B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); common variable immunodeficiency 13 (Disease Ontology:DOID:0081155); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:305501); (R-RNO-9940951)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032993 protein-DNA complex;GO:0032991 protein-containing complex;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2JVD9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZDS9-1", "uniprot_id": [ { "id": "D3ZDS9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZDS9", "type": "external" } ], "mass": 72021.0, "length": 643, "protein_name": "Interferon alpha/beta receptor 1", "gene_name": "Ifnar1", "organism": "Rat", "refseq_name": "interferon alpha/beta receptor 1 isoform X1", "refseq_ac": [ { "id": "XP_063126497", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063126497", "type": "external" } ], "gene_names_uniprotkb": "Ifnar1", "gene_names_refseq": "Ifnar1", "protein_names_uniprotkb": "Interferon alpha/beta receptor 1; Type I interferon receptor 1", "protein_names_refseq": "interferon alpha/beta receptor 1 isoform X1", "tax_id": 10116, "disease": "immunodeficiency 106 (Disease Ontology:DOID:0061075); hepatitis C (Disease Ontology:DOID:1883)", "pathway": " (rno:288264); (R-RNO-909733); (R-RNO-912694)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019955 cytokine binding;GO:0004904 interferon receptor activity;GO:0008269 JAK pathway signal transduction adaptor activity;GO:0004905 type I interferon receptor activity;GO:0019962 type I interferon binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0032496 response to lipopolysaccharide;GO:0051607 defense response to virus;GO:0042110 T cell activation;GO:0060337 type I interferon-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZDS9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JZE8-1", "uniprot_id": [ { "id": "A0A0G2JZE8_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JZE8", "type": "external" } ], "mass": 56197.0, "length": 504, "protein_name": "Target of EGR1 protein 1", "gene_name": "Toe1", "organism": "Rat", "refseq_name": "target of EGR1 protein 1 isoform 1", "refseq_ac": [ { "id": "NP_001385980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385980", "type": "external" } ], "gene_names_uniprotkb": "Toe1", "gene_names_refseq": "Toe1", "protein_names_uniprotkb": "Target of EGR1 protein 1", "protein_names_refseq": "target of EGR1 protein 1 isoform 1; target of EGR1 protein 1; target of EGR1, member 1 (nuclear)", "tax_id": 10116, "disease": "pontocerebellar hypoplasia type 7 (Disease Ontology:DOID:0060276)", "pathway": " (rno:298443)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0017069 snRNA binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0034472 snRNA 3'-end processing;GO:0016070 RNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A0G2JZE8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K2H4-1", "uniprot_id": [ { "id": "A0A0G2K2H4_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K2H4", "type": "external" } ], "mass": 110151.0, "length": 977, "protein_name": "Serine/threonine-protein kinase/endoribonuclease IRE1", "gene_name": "Ern1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase/endoribonuclease IRE1 precursor", "refseq_ac": [ { "id": "NP_001430595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001430595", "type": "external" } ], "gene_names_uniprotkb": "Ern1", "gene_names_refseq": "Ern1; RGD1559716", "protein_names_uniprotkb": "Serine/threonine-protein kinase/endoribonuclease IRE1; 2.7.11.1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; Ire1-alpha", "protein_names_refseq": "endoplasmic reticulum (ER) to nucleus signalling 1; serine/threonine-protein kinase/endoribonuclease IRE1 precursor; serine/threonine-protein kinase/endoribonuclease IRE1", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); oropharynx cancer (Disease Ontology:DOID:8557)", "pathway": " (rno:498013); (R-RNO-381070)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "32272965;32950473;33179109;35085541;38336929", "class_list": "", "function": "Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization. Publication Status: Online-Only, [RefSeq, PubMed]; Endoplasmic reticulum stress related factor IRE1alpha regulates TXNIP/NLRP3-mediated pyroptosis in diabetic nephropathy., [RefSeq, PubMed]; Hyperoxia induces endoplasmic reticulum stressassociated apoptosis via the IRE1α pathway in rats with bronchopulmonary dysplasia., [RefSeq, PubMed]; Inhibition of IRE1 suppresses the catabolic effect of IL-1beta on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo., [RefSeq, PubMed]; Novel insight on IRE1 in the regulation of chondrocyte dedifferentiation through ER stress independent pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, 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"2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:1990604 IRE1-TRAF2-ASK1 complex;GO:1990630 IRE1-RACK1-PP2A complex;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation;GO:1901142 insulin metabolic process;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A0G2K2H4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEN0-1", "uniprot_id": [ { "id": "MILK2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEN0", "type": "external" } ], "mass": 108382.0, "length": 1014, "protein_name": "MICAL-like protein 2", "gene_name": "Micall2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Micall2; Jrab", "gene_names_refseq": "", "protein_names_uniprotkb": "MICAL-like protein 2; Junctional Rab13-binding protein; MICAL-L2; Molecule interacting with CasL-like 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:288515)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20008558;29393594", "class_list": "", "function": "Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth. Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0031267 small GTPase binding;GO:0031005 filamin binding;GO:0042805 actinin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0055037 recycling endosome;GO:0001725 stress fiber", "go_biological_process": "GO:0031175 neuron projection development;GO:0030036 actin cytoskeleton organization;GO:0034446 substrate adhesion-dependent cell spreading;GO:0030041 actin filament polymerization;GO:0070830 bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZEN0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2KB91-1", "uniprot_id": [ { "id": "A0A0G2KB91_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2KB91", "type": "external" } ], "mass": 40435.0, "length": 386, "protein_name": "Zinc finger protein 385A", "gene_name": "Zfp385a", "organism": "Rat", "refseq_name": "zinc finger protein 385A isoform 2", "refseq_ac": [ { "id": "NP_001102940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102940", "type": "external" } ], "gene_names_uniprotkb": "Zfp385a", "gene_names_refseq": "Zfp385a; Zfp385", "protein_names_uniprotkb": "Zinc finger protein 385A", "protein_names_refseq": "zinc finger protein 385A isoform 2; zinc finger protein 385", "tax_id": 10116, "disease": "", "pathway": " (rno:685474); (R-RNO-6804759); (R-RNO-69895)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0003730 mRNA 3'-UTR binding;GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0000785 chromatin", "go_biological_process": "GO:2000765 regulation of cytoplasmic translation;GO:0010609 mRNA localization resulting in post-transcriptional regulation of gene expression;GO:0006915 apoptotic process;GO:0006974 DNA damage response;GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2KB91-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K4A8-1", "uniprot_id": [ { "id": "A0A0G2K4A8_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K4A8", "type": "external" } ], "mass": 115364.0, "length": 1042, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "Lats2", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase LATS2", "refseq_ac": [ { "id": "NP_001100737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100737", "type": "external" } ], "gene_names_uniprotkb": "Lats2", "gene_names_refseq": "Lats2", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "large tumor suppressor 2; large tumor suppressor, homolog 2; serine/threonine-protein kinase LATS2", "tax_id": 10116, "disease": "benign neoplasm (Disease Ontology:DOID:0060072); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); peripheral nerve sheath neoplasm (Disease Ontology:DOID:3193); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:305922); (R-RNO-2028269)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "31829064;32054526;32375631", "class_list": "", "function": "Exosomal miR-135a derived from human amnion mesenchymal stem cells promotes cutaneous wound healing in rats and fibroblast migration by directly inhibiting LATS2 expression. Publication Status: Online-Only, [RefSeq, PubMed]; The overexpression of LATS2 induces mitochondrial stress by repressing protective mitophagy in a manner dependent on Prx3-Mfn2 pathways, thus reducing the survival of H9C2 cells., [RefSeq, PubMed]; Upregulation of miR-215 attenuates propofol-induced apoptosis and oxidative stress in developing neurons by targeting LATS2. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A0G2K4A8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9C4-1", "uniprot_id": [ { "id": "D3Z9C4_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9C4", "type": "external" } ], "mass": 57015.0, "length": 504, "protein_name": "Hexosyltransferase", "gene_name": "B3galnt2", "organism": "Rat", "refseq_name": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 2", "refseq_ac": [ { "id": "NP_001138323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138323", "type": "external" } ], "gene_names_uniprotkb": "B3galnt2", "gene_names_refseq": "B3galnt2; RGD1306946", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 2; UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2", "tax_id": 10116, "disease": "congenital muscular dystrophy-dystroglycanopathy type A11 (Disease Ontology:DOID:0111230)", "pathway": " (rno:291212); (R-RNO-8932505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0016758 hexosyltransferase activity;GO:0008194 UDP-glycosyltransferase activity;GO:0008376 acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z9C4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K5L2-1", "uniprot_id": [ { "id": "GHC1_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K5L2", "type": "external" } ], "mass": 34662.0, "length": 323, "protein_name": "Mitochondrial glutamate carrier 1", "gene_name": "Slc25a22", "organism": "Rat", "refseq_name": "mitochondrial glutamate carrier 1 isoform 3", "refseq_ac": [ { "id": "NP_001014049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014049", "type": "external" } ], "gene_names_uniprotkb": "Slc25a22; Gc1", "gene_names_refseq": "GC-1; GC1; RGD1307826; Slc25a22", "protein_names_uniprotkb": "Mitochondrial glutamate carrier 1; GC-1; Glutamate/H(+) symporter 1; Solute carrier family 25 member 22", "protein_names_refseq": "glutamate/H(+) symporter 1; mitochondrial glutamate carrier 1 isoform 3; mitochondrial glutamate carrier 1-like; mitochondrial glutamate carrier 1; solute carrier family 25 (mitochondrial carrier, glutamate), member 22", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 3 (Disease Ontology:DOID:0080440)", "pathway": " (rno:309111); (R-RNO-442660); (R-RNO-9856872)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19584051;38843836", "class_list": "", "function": "Insulin-secreting cells depend on GC1 for maximal glucose response., [RefSeq, PubMed]; Mitochondrial glutamate/H(+) symporter (By similarity). Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (Probable). Plays a role in the control of glucose-stimulated insulin secretion (PubMed:19584051)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZRF5;Q5FVG4", "ec_number_list": [], "go_molecular_function": "GO:0005280 amino acid:proton symporter activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0050796 regulation of insulin secretion;GO:0015810 aspartate transmembrane transport;GO:0015813 L-glutamate transmembrane transport;GO:0043490 malate-aspartate shuttle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A0G2K5L2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZRC4-1", "uniprot_id": [ { "id": "PLPL8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZRC4", "type": "external" } ], "mass": 87961.0, "length": 776, "protein_name": "Calcium-independent phospholipase A2-gamma", "gene_name": "Pnpla8", "organism": "Rat", "refseq_name": "calcium-independent phospholipase A2-gamma", "refseq_ac": [ { "id": "NP_001101490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101490", "type": "external" } ], "gene_names_uniprotkb": "Pnpla8", "gene_names_refseq": "Pnpla8; RGD1311444", "protein_names_uniprotkb": "Calcium-independent phospholipase A2-gamma; 3.1.1.-; 3.1.1.5; Intracellular membrane-associated calcium-independent phospholipase A2 gamma; Patatin-like phospholipase domain-containing protein 8; iPLA2-gamma", "protein_names_refseq": "calcium-independent phospholipase A2-gamma; iPLA2-gamma; intracellular membrane-associated calcium-independent phospholipase A2 gamma; patatin-like phospholipase domain containing 8; patatin-like phospholipase domain-containing protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:314075); (R-RNO-1482788); (R-RNO-1482839)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15908428;29393594", "class_list": "", "function": "Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors. Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former. Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine. However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates. Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers. Can also hydrolyze lysophosphatidylcholine. In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" } ], "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0004620 phospholipase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0046338 phosphatidylethanolamine catabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0006631 fatty acid metabolic process;GO:0035556 intracellular signal transduction;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZRC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ADE6-1", "uniprot_id": [ { "id": "D4ADE6_RAT", "url": "https://www.uniprot.org/uniprot/D4ADE6", "type": "external" } ], "mass": 104906.0, "length": 1004, "protein_name": "Sal-like protein 2", "gene_name": "Sall2", "organism": "Rat", "refseq_name": "sal-like protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001100732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100732", "type": "external" } ], "gene_names_uniprotkb": "Sall2", "gene_names_refseq": "Sall2", "protein_names_uniprotkb": "Sal-like protein 2; Zinc finger protein Spalt-2", "protein_names_refseq": "sal-like 2; sal-like protein 2 isoform 2; sal-like protein 2", "tax_id": 10116, "disease": "coloboma (Disease Ontology:DOID:12270); carcinoma (Disease Ontology:DOID:305)", "pathway": " (rno:305854)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19131967", "class_list": "", "function": "Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure., [UniProtKB, UniProtKB, UniProtKB]; These data establish Sall2 as a link between p75 neurotrophin receptor and transcriptional events that regulate the growth and development of neuronal cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4ADE6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5R8-1", "uniprot_id": [ { "id": "SANBR_RAT", "url": "https://www.uniprot.org/uniprot/A1A5R8", "type": "external" } ], "mass": 84345.0, "length": 737, "protein_name": "SANT and BTB domain regulator of class switch recombination", "gene_name": "Sanbr", "organism": "Rat", "refseq_name": "SANT and BTB domain regulator of class switch recombination isoform 1", "refseq_ac": [ { "id": "NP_001094441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094441", "type": "external" } ], "gene_names_uniprotkb": "Sanbr; RGD1305110", "gene_names_refseq": "RGD1305110; Sanbr", "protein_names_uniprotkb": "SANT and BTB domain regulator of class switch recombination; SANT and BTB domain regulator of CSR", "protein_names_refseq": "SANT and BTB domain regulator of class switch recombination isoform 1; SANT and BTB domain regulator of class switch recombination", "tax_id": 10116, "disease": "", "pathway": " (rno:305579)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Negatively regulates class switch recombination or isotype switching in splenic B-cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0045190 isotype switching", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1A5R8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2K9E9-1", "uniprot_id": [ { "id": "A0A0G2K9E9_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2K9E9", "type": "external" } ], "mass": 28472.0, "length": 258, "protein_name": "Ciliogenesis and planar polarity effector 2", "gene_name": "Cplane2", "organism": "Rat", "refseq_name": "ciliogenesis and planar polarity effector 2 isoform 1", "refseq_ac": [ { "id": "NP_001425258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001425258", "type": "external" } ], "gene_names_uniprotkb": "Cplane2; LOC120103024; Rsg1", "gene_names_refseq": "Cplane2; RGD1561421; Rsg1", "protein_names_uniprotkb": "Ciliogenesis and planar polarity effector 2; REM2- and Rab-like small GTPase 1", "protein_names_refseq": "REM2 and RAB-like small GTPase 1; ciliogenesis and planar polarity effector 2 isoform 1; ciliogenesis and planar polarity effector 2", "tax_id": 10116, "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); VACTERL association (Disease Ontology:DOID:14679)", "pathway": " (rno:500576)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for efficient primary cilia initiation, regulating a late step in cilia initiation. Plays a role in the final maturation of the mother centriole and ciliary vesicle that allows extension of the ciliary axoneme., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005814 centriole;GO:0036064 ciliary basal body;GO:0097546 ciliary base;GO:0035869 ciliary transition zone", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0015031 protein transport;GO:0016485 protein processing;GO:0060271 cilium assembly;GO:0060173 limb development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2K9E9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2KAY0-1", "uniprot_id": [ { "id": "A0A0G2KAY0_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2KAY0", "type": "external" } ], "mass": 72558.0, "length": 678, "protein_name": "Growth arrest-specific 2 like 1", "gene_name": "Gas2l1", "organism": "Rat", "refseq_name": "GAS2-like protein 1", "refseq_ac": [ { "id": "NP_001388335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388335", "type": "external" } ], "gene_names_uniprotkb": "Gas2l1", "gene_names_refseq": "Gas2l1", "protein_names_uniprotkb": "Growth arrest-specific 2 like 1", "protein_names_refseq": "GAS2-like protein 1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "31486213", "class_list": "", "function": "The microtubule-binding tail region of Gas2L1 directs its actin-stabilizing activity towards the axon. We propose that Gas2L1 acts as an actin regulator, the function of which is spatially modulated by microtubules., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008093 cytoskeletal anchor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005884 actin filament;GO:0001725 stress fiber;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0007026 negative regulation of microtubule depolymerization;GO:0009267 cellular response to starvation;GO:0001578 microtubule bundle formation;GO:1904825 protein localization to microtubule plus-end", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A0G2KAY0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2KB27-1", "uniprot_id": [ { "id": "A0A0G2KB27_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2KB27", "type": "external" } ], "mass": 31284.0, "length": 273, "protein_name": "Nucleoporin 62 C-terminal like", "gene_name": "Nup62cl", "organism": "Rat", "refseq_name": "nucleoporin-62 C-terminal-like protein", "refseq_ac": [ { "id": "NP_001414534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414534", "type": "external" } ], "gene_names_uniprotkb": "Nup62cl", "gene_names_refseq": "Nup62cl; RGD1564353", "protein_names_uniprotkb": "Nucleoporin 62 C-terminal like", "protein_names_refseq": "nucleoporin-62 C-terminal-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:300923)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0006405 RNA export from nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0G2KB27-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZL9-1", "uniprot_id": [ { "id": "GCC2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZL9", "type": "external" } ], "mass": 195083.0, "length": 1679, "protein_name": "GRIP and coiled-coil domain-containing protein 2", "gene_name": "Gcc2", "organism": "Rat", "refseq_name": "GRIP and coiled-coil domain-containing protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001101103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101103", "type": "external" } ], "gene_names_uniprotkb": "Gcc2; Gcc185", "gene_names_refseq": "Gcc2", "protein_names_uniprotkb": "GRIP and coiled-coil domain-containing protein 2; 185 kDa Golgi coiled-coil protein", "protein_names_refseq": "185 kDa Golgi coiled-coil protein; GRIP and coiled-coil domain-containing protein 2 isoform 2; GRIP and coiled-coil domain-containing protein 2; LIM and senescent cell antigen-like domains 1", "tax_id": 10116, "disease": "", "pathway": " (rno:309798); (R-RNO-6811440)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16885419;29393594", "class_list": "", "function": "Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006622 protein targeting to lysosome;GO:0042147 retrograde transport, endosome to Golgi;GO:0090161 Golgi ribbon formation;GO:0034067 protein localization to Golgi apparatus;GO:0034453 microtubule anchoring", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZZL9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPN6-1", "uniprot_id": [ { "id": "MED22_RAT", "url": "https://www.uniprot.org/uniprot/A0JPN6", "type": "external" } ], "mass": 22312.0, "length": 200, "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "Med22", "organism": "Rat", "refseq_name": "mediator of RNA polymerase II transcription subunit 22", "refseq_ac": [ { "id": "NP_001071147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071147", "type": "external" } ], "gene_names_uniprotkb": "Med22; Surf5", "gene_names_refseq": "Med22; RGD1564893; Surf5", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 22; Mediator complex subunit 22; Surfeit locus protein 5", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 22-like; mediator of RNA polymerase II transcription subunit 22; surfeit 5; surfeit locus protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:499762)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JPN6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPP7-1", "uniprot_id": [ { "id": "DDI1_RAT", "url": "https://www.uniprot.org/uniprot/A0JPP7", "type": "external" } ], "mass": 45451.0, "length": 408, "protein_name": "Protein DDI1 homolog 1", "gene_name": "Ddi1", "organism": "Rat", "refseq_name": "protein DDI1 homolog 1", "refseq_ac": [ { "id": "NP_001078944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078944", "type": "external" } ], "gene_names_uniprotkb": "Ddi1", "gene_names_refseq": "Ddi1; RGD1559430", "protein_names_uniprotkb": "Protein DDI1 homolog 1; 3.4.23.-", "protein_names_refseq": "DNA-damage inducible 1 homolog 1; protein DDI1 homolog 1", "tax_id": 10116, "disease": "", "pathway": " (rno:367012)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redundantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0031647 regulation of protein stability;GO:0010498 proteasomal protein catabolic process;GO:0097752 regulation of DNA stability;GO:0072711 cellular response to hydroxyurea", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JPP7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5P9-1", "uniprot_id": [ { "id": "MAGE1_RAT", "url": "https://www.uniprot.org/uniprot/A1A5P9", "type": "external" } ], "mass": 102181.0, "length": 933, "protein_name": "Melanoma-associated antigen E1", "gene_name": "Magee1", "organism": "Rat", "refseq_name": "melanoma-associated antigen E1", "refseq_ac": [ { "id": "NP_001073360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073360", "type": "external" } ], "gene_names_uniprotkb": "Magee1", "gene_names_refseq": "DAMAGE; Magee1; RGD1560259", "protein_names_uniprotkb": "Melanoma-associated antigen E1; Alpha-dystrobrevin-associated MAGE Protein; DAMAGE; MAGE-E1 antigen", "protein_names_refseq": "MAGE-E1 antigen; alpha-dystrobrevin-associated MAGE Protein; hepatocellular carcinoma-associated protein HCA1; melanoma antigen, family E, 1; melanoma-associated antigen E1", "tax_id": 10116, "disease": "", "pathway": " (rno:317232)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045211 postsynaptic membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1A5P9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4L9P5-1", "uniprot_id": [ { "id": "HIPK1_RAT", "url": "https://www.uniprot.org/uniprot/A4L9P5", "type": "external" } ], "mass": 130801.0, "length": 1211, "protein_name": "Homeodomain-interacting protein kinase 1", "gene_name": "Hipk1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hipk1", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeodomain-interacting protein kinase 1; 2.7.11.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:365895); (R-RNO-6804756)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation (By similarity). Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4L9P6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0060059 embryonic retina morphogenesis in camera-type eye;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0008284 positive regulation of cell population proliferation;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4L9P5-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4ZYQ5-1", "uniprot_id": [ { "id": "GTR7_RAT", "url": "https://www.uniprot.org/uniprot/A4ZYQ5", "type": "external" } ], "mass": 55691.0, "length": 512, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 7", "gene_name": "Slc2a7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc2a7; GLUT7; LOC100362644", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 7; GLUT-7; Glucose transporter type 7", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-189200)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable sugar transporter. Even if its physiological substrate is subject to discussion, it is able to transport glucose and fructose. Does not transport galactose, 2-deoxy-d-glucose and xylose., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0015755 fructose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4ZYQ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9UMV8-1", "uniprot_id": [ { "id": "H2AJ_RAT", "url": "https://www.uniprot.org/uniprot/A9UMV8", "type": "external" } ], "mass": 14045.0, "length": 129, "protein_name": "Histone H2A.J", "gene_name": "H2aj", "organism": "Rat", "refseq_name": "histone H2A.J", "refseq_ac": [ { "id": "NP_001103080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103080", "type": "external" } ], "gene_names_uniprotkb": "H2aj; H2ac20; H2ax", "gene_names_refseq": "H2a/j; H2afj; H2aj", "protein_names_uniprotkb": "Histone H2A.J; H2a/j", "protein_names_refseq": "H2A histone family, member J; histone H2A.J-like; histone H2A.J", "tax_id": 10116, "disease": "", "pathway": " (rno:690795); (R-RNO-110330); (R-RNO-110331); (R-RNO-212300); (R-RNO-2299718); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559586); (R-RNO-427359); (R-RNO-427413); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-5625886); (R-RNO-606279); (R-RNO-68616); (R-RNO-73728); (R-RNO-73772); (R-RNO-8936459); (R-RNO-9018519); (R-RNO-9764725); (R-RNO-9841922); (R-RNO-9843940); (R-RNO-9843970); (R-RNO-9909649); (R-RNO-9940951); (R-RNO-9943411); (R-RNO-9943962)", "pathway_count": 27, "publication_count": 2, "publication_id_list": "38843836;9211995", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome;GO:0005654 nucleoplasm", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A9UMV8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BMX9-1", "uniprot_id": [ { "id": "MEIOB_RAT", "url": "https://www.uniprot.org/uniprot/B0BMX9", "type": "external" } ], "mass": 52819.0, "length": 470, "protein_name": "Meiosis-specific with OB domain-containing protein", "gene_name": "Meiob", "organism": "Rat", "refseq_name": "meiosis-specific with OB domain-containing protein", "refseq_ac": [ { "id": "NP_001108505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108505", "type": "external" } ], "gene_names_uniprotkb": "Meiob", "gene_names_refseq": "Meiob", "protein_names_uniprotkb": "Meiosis-specific with OB domain-containing protein; 3.1.-.-", "protein_names_refseq": "meiosis specific with OB domains; meiosis-specific with OB domain-containing protein; uncharacterized protein C16orf73 homolog", "tax_id": 10116, "disease": "spermatogenic failure 22 (Disease Ontology:DOID:0070177); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (rno:685099)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0003682 chromatin binding;GO:0003697 single-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0007144 female meiosis I;GO:0009566 fertilization;GO:0007140 male meiotic nuclear division;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BMX9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN95-1", "uniprot_id": [ { "id": "HARB1_RAT", "url": "https://www.uniprot.org/uniprot/B0BN95", "type": "external" } ], "mass": 38741.0, "length": 349, "protein_name": "Putative nuclease HARBI1", "gene_name": "Harbi1", "organism": "Rat", "refseq_name": "putative nuclease HARBI1", "refseq_ac": [ { "id": "NP_001107265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107265", "type": "external" } ], "gene_names_uniprotkb": "Harbi1", "gene_names_refseq": "Harbi1", "protein_names_uniprotkb": "Putative nuclease HARBI1; 3.1.-.-; Harbinger transposase-derived nuclease", "protein_names_refseq": "Harbinger transposase-derived nuclease; putative nuclease HARBI1", "tax_id": 10116, "disease": "", "pathway": " (rno:690164)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004518 nuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BN95-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BND5-1", "uniprot_id": [ { "id": "B0BND5_RAT", "url": "https://www.uniprot.org/uniprot/B0BND5", "type": "external" } ], "mass": 52503.0, "length": 478, "protein_name": "U3 small nucleolar RNA-interacting protein 2", "gene_name": "Rrp9", "organism": "Rat", "refseq_name": "U3 small nucleolar RNA-interacting protein 2", "refseq_ac": [ { "id": "NP_001102248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102248", "type": "external" } ], "gene_names_uniprotkb": "Rrp9", "gene_names_refseq": "Rnu3ip2; Rrp9", "protein_names_uniprotkb": "U3 small nucleolar RNA-interacting protein 2; RRP9 homolog; U3 small nucleolar ribonucleoprotein-associated 55 kDa protein", "protein_names_refseq": "RNA, U3 small nucleolar interacting protein 2; RRP9, small subunit (SSU) processome component, homolog; U3 small nucleolar RNA-interacting protein 2; ribosomal RNA processing 9, small subunit (SSU) processome component, homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:363134); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding;GO:0034511 U3 snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0031428 box C/D methylation guide snoRNP complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0BND5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0JYS4-1", "uniprot_id": [ { "id": "B0JYS4_RAT", "url": "https://www.uniprot.org/uniprot/B0JYS4", "type": "external" } ], "mass": 27981.0, "length": 263, "protein_name": "Mitogen-activated protein kinase 1 interacting protein 1", "gene_name": "Mapk1ip1", "organism": "Rat", "refseq_name": "MAPK-interacting and spindle-stabilizing protein", "refseq_ac": [ { "id": "NP_001406432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406432", "type": "external" } ], "gene_names_uniprotkb": "Mapk1ip1", "gene_names_refseq": "Mapk1ip1; RGD1565431", "protein_names_uniprotkb": "Mitogen-activated protein kinase 1 interacting protein 1", "protein_names_refseq": "MAPK-interacting and spindle-stabilizing protein", "tax_id": 10116, "disease": "", "pathway": " (rno:499280)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0JYS4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1H245-1", "uniprot_id": [ { "id": "B1H245_RAT", "url": "https://www.uniprot.org/uniprot/B1H245", "type": "external" } ], "mass": 22252.0, "length": 202, "protein_name": "BAF chromatin remodeling complex subunit BCL7B", "gene_name": "Bcl7b", "organism": "Rat", "refseq_name": "B-cell CLL/lymphoma 7 protein family member B", "refseq_ac": [ { "id": "NP_001407864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001407864", "type": "external" } ], "gene_names_uniprotkb": "Bcl7b", "gene_names_refseq": "Bcl7b", "protein_names_uniprotkb": "BAF chromatin remodeling complex subunit BCL7B", "protein_names_refseq": "B-cell CLL/lymphoma 7 protein family member B; B-cell CLL/lymphoma 7B; BCL tumor suppressor 7B; BCL7B, BAF complex component", "tax_id": 10116, "disease": "", "pathway": " (rno:368001); (R-RNO-9933937); (R-RNO-9933939); (R-RNO-9933946); (R-RNO-9933947); (R-RNO-9934037)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LP28", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016514 SWI/SNF complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1H245-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1Q005-1", "uniprot_id": [ { "id": "MBOA4_RAT", "url": "https://www.uniprot.org/uniprot/B1Q005", "type": "external" } ], "mass": 50008.0, "length": 435, "protein_name": "Membrane-bound ghrelin O-acyltransferase MBOAT4", "gene_name": "Mboat4", "organism": "Rat", "refseq_name": "membrane-bound ghrelin O-acyltransferase MBOAT4", "refseq_ac": [ { "id": "NP_001100787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100787", "type": "external" } ], "gene_names_uniprotkb": "Mboat4; Goat", "gene_names_refseq": "Mboat4; RGD1566335", "protein_names_uniprotkb": "Membrane-bound ghrelin O-acyltransferase MBOAT4; 2.3.1.-; Membrane-bound O-acyltransferase domain-containing protein 4", "protein_names_refseq": "ghrelin O-acyltransferase; membrane bound O-acyltransferase domain containing 4; membrane-bound O-acyltransferase domain-containing protein 4; membrane-bound ghrelin O-acyltransferase MBOAT4", "tax_id": 10116, "disease": "", "pathway": " (rno:306515); (R-RNO-422085)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "18443287;18835978;19628676;20059966;20149910;21063108;26028164;29063591;35180934", "class_list": "", "function": "Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (By similarity) (PubMed:18443287). In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient (By similarity)., [UniProtKB, PubMed, UniProtKB]; Expression of hypothalamic ghrelin O-acyltransferase have an effect on body mass of rats fed a high-fat diet., [RefSeq, PubMed]; Findings suggest that increased GOAT mRNA levels may have a role in mediating the physiological responses to chronic undernutrition and could represent an adaptive response to prevent long-lasting alterations in energy balance and body weight homeostasis, [RefSeq, PubMed]; GOAT immunoreactivity is aggregated at the base of the dentate granule cell layer in the rat. This immunoreactivity was not affected by the pharmacological inhibition of GHSR1a or the metabolic state-dependent fluctuation of systemic ghrelin levels., [RefSeq, PubMed]; Ghrelin O-acyltransferase is present in murine pancreatic islet cells and that insulin inhibits the expression of ghrelin O-acyltransferase by the mediation of mTOR signaling., [RefSeq, PubMed]; Ghrelin-O-acyltransferase (GOAT) acylates ghrelin in the hippocampus., [RefSeq, PubMed]; Ghrelin-O-acyltransferase (GOAT) mRNA in the stomach was up-regulated 21-fold in adult rats compared to young rats and 14-fold compared to adult dietary restriction rats., [RefSeq, PubMed]; The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin., [RefSeq, PubMed]; These data suggest species differences between rats and mice in gastric GOAT expression perhaps resulting in a different role of the MBOAT4 enzyme in the rat stomach., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" } ], "go_molecular_function": "GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:0016412 serine O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0018191 peptidyl-serine octanoylation;GO:0030258 lipid modification;GO:0018190 protein octanoylation;GO:0043543 protein acylation;GO:0051366 protein decanoylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "B1Q005-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WC37-1", "uniprot_id": [ { "id": "MTU1_RAT", "url": "https://www.uniprot.org/uniprot/B1WC37", "type": "external" } ], "mass": 49724.0, "length": 441, "protein_name": "Mitochondrial tRNA-specific 2-thiouridylase 1", "gene_name": "Trmu", "organism": "Rat", "refseq_name": "mitochondrial tRNA-specific 2-thiouridylase 1 isoform 2", "refseq_ac": [ { "id": "NP_001388104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388104", "type": "external" } ], "gene_names_uniprotkb": "Trmu; Mtu1", "gene_names_refseq": "Mtu1; Trmu", "protein_names_uniprotkb": "Mitochondrial tRNA-specific 2-thiouridylase 1; 2.8.1.14", "protein_names_refseq": "mitochondrial tRNA-specific 2-thiouridylase 1 isoform 2; mitochondrial tRNA-specific 2-thiouridylase 1; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 1; tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase", "tax_id": 10116, "disease": "infantile liver failure syndrome (Disease Ontology:DOID:0080716); transient infantile liver failure (Disease Ontology:DOID:0080778); aminoglycoside-induced deafness (Disease Ontology:DOID:0111734); inner ear disease (Disease Ontology:DOID:2952); MERRF syndrome (Disease Ontology:DOID:310); liver disease (Disease Ontology:DOID:409)", "pathway": " (rno:362976)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0061708 tRNA-5-taurinomethyluridine 2-sulfurtransferase", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WC37-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WC68-1", "uniprot_id": [ { "id": "HDAC8_RAT", "url": "https://www.uniprot.org/uniprot/B1WC68", "type": "external" } ], "mass": 41754.0, "length": 377, "protein_name": "Histone deacetylase 8", "gene_name": "Hdac8", "organism": "Rat", "refseq_name": "histone deacetylase 8", "refseq_ac": [ { "id": "NP_001119845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119845", "type": "external" } ], "gene_names_uniprotkb": "Hdac8", "gene_names_refseq": "HD8; Hdac8; RGD1562895", "protein_names_uniprotkb": "Histone deacetylase 8; 3.5.1.-; 3.5.1.98; HD8; Protein deacetylase HDAC8; Protein decrotonylase HDAC8", "protein_names_refseq": "histone deacetylase 8; protein deacetylase HDAC8; protein decrotonylase HDAC8", "tax_id": 10116, "disease": "Wilson-Turner syndrome (Disease Ontology:DOID:0060814); Cornelia de Lange syndrome 5 (Disease Ontology:DOID:0080509); Hirschsprung's disease (Disease Ontology:DOID:10487); hypertension (Disease Ontology:DOID:10763); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); renovascular hypertension (Disease Ontology:DOID:1591); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (rno:363481); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3214815); (R-RNO-350054)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "29393346;29393594", "class_list": "", "function": "Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that HDAC4 and HDAC8 may serve as key upstream mediators of MAPK in regulating the IL1betainduced cartilage catabolic and degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.5.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48", "type": "external" }, { "id": "3.5.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0019213 deacetylase activity;GO:0051879 Hsp90 protein binding;GO:0004407 histone deacetylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0000118 histone deacetylase complex;GO:0005634 nucleus", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:1904322 cellular response to forskolin;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "B1WC68-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2BKZ7-1", "uniprot_id": [ { "id": "B2BKZ7_RAT", "url": "https://www.uniprot.org/uniprot/B2BKZ7", "type": "external" } ], "mass": 20862.0, "length": 190, "protein_name": "Ring finger protein 227", "gene_name": "Rnf227", "organism": "Rat", "refseq_name": "RING finger protein 227", "refseq_ac": [ { "id": "NP_001119764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119764", "type": "external" } ], "gene_names_uniprotkb": "Rnf227; RGD1563441", "gene_names_refseq": "RGD1563441; Rnf227", "protein_names_uniprotkb": "Ring finger protein 227", "protein_names_refseq": "RING finger protein 227", "tax_id": 10116, "disease": "", "pathway": " (rno:497935)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2BKZ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYH9-1", "uniprot_id": [ { "id": "S71A2_RAT", "url": "https://www.uniprot.org/uniprot/B2RYH9", "type": "external" } ], "mass": 54936.0, "length": 507, "protein_name": "Solute carrier family 71 member 2", "gene_name": "Slc71a2", "organism": "Rat", "refseq_name": "solute carrier family 71 member 2", "refseq_ac": [ { "id": "NP_001100804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100804", "type": "external" } ], "gene_names_uniprotkb": "Slc71a2; Hiatl1; Mfsd14b", "gene_names_refseq": "Hiatl1; Mfsd14b; RGD1308377; Slc71a2", "protein_names_uniprotkb": "Solute carrier family 71 member 2; Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain-containing 14B", "protein_names_refseq": "hippocampus abundant transcript-like 1; hippocampus abundant transcript-like protein 1; major facilitator superfamily domain containing 14B; solute carrier family 71 member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:306687)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable membrane-bound transporter. May play a role in neuronal nutrient sensing and energy homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYH9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYT6-1", "uniprot_id": [ { "id": "B2RYT6_RAT", "url": "https://www.uniprot.org/uniprot/B2RYT6", "type": "external" } ], "mass": 12698.0, "length": 104, "protein_name": "Transcription elongation factor A like 9", "gene_name": "Tceal9", "organism": "Rat", "refseq_name": "transcription elongation factor A protein-like 9", "refseq_ac": [ { "id": "NP_001120974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120974", "type": "external" } ], "gene_names_uniprotkb": "Tceal9; Wbp5", "gene_names_refseq": "RGD1560111; Tceal9; Wbp5", "protein_names_uniprotkb": "Transcription elongation factor A like 9", "protein_names_refseq": "WW domain-binding protein 5; transcription elongation factor A protein-like 9", "tax_id": 10116, "disease": "", "pathway": " (rno:680354)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050699 WW domain binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYT6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZ87-1", "uniprot_id": [ { "id": "MADL2_RAT", "url": "https://www.uniprot.org/uniprot/B2RZ87", "type": "external" } ], "mass": 33165.0, "length": 307, "protein_name": "Myeloid-associated differentiation marker-like protein 2", "gene_name": "Myadml2", "organism": "Rat", "refseq_name": "myeloid-associated differentiation marker-like protein 2", "refseq_ac": [ { "id": "NP_001121657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121657", "type": "external" } ], "gene_names_uniprotkb": "Myadml2", "gene_names_refseq": "Myadml2; 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The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004526 ribonuclease P activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:0030678 mitochondrial ribonuclease P complex", "go_biological_process": "GO:0001682 tRNA 5'-leader removal;GO:0097745 mitochondrial tRNA 5'-end processing;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DF07-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B6CZ61-1", "uniprot_id": [ { "id": "LRC51_RAT", "url": "https://www.uniprot.org/uniprot/B6CZ61", "type": "external" } ], "mass": 22162.0, "length": 192, "protein_name": "Leucine-rich repeat-containing protein 51", "gene_name": "Lrrc51", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 51", "refseq_ac": [ { "id": "NP_001099754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099754", "type": "external" } ], "gene_names_uniprotkb": "Lrrc51", "gene_names_refseq": "Lrrc51; RGD1565856", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 51", "protein_names_refseq": "leucine-rich repeat-containing protein 51", "tax_id": 10116, "disease": "", "pathway": " (rno:293156)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18953341", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B6CZ61-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B8ZHC9-1", "uniprot_id": [ { "id": "S2541_RAT", "url": "https://www.uniprot.org/uniprot/B8ZHC9", "type": "external" } ], "mass": 34557.0, "length": 312, "protein_name": "Calcium-independent mitochondrial carrier protein SCaMC-3L", "gene_name": "Slc25a41", "organism": "Rat", "refseq_name": "calcium-independent mitochondrial carrier protein SCaMC-3L", "refseq_ac": [ { "id": "NP_001100344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100344", "type": "external" } ], "gene_names_uniprotkb": "Slc25a41; rCG_45007", "gene_names_refseq": "SCaMC-3L; Slc25a41", "protein_names_uniprotkb": "Calcium-independent mitochondrial carrier protein SCaMC-3L; Mitochondrial ATP-Mg/Pi carrier protein SLC25A41; SCaMC-3-like; SCaMC-3L; Small calcium-binding mitochondrial carrier protein 3-like; Solute carrier family 25 member 41", "protein_names_refseq": "SCaMC-3-like; calcium-independent mitochondrial carrier protein SCaMC-3L; mitochondrial ATP-Mg/Pi carrier protein SLC25A41; mitochondrial ATP-Mg/Pi carrier protein; small calcium-binding mitochondrial carrier protein 3-like", "tax_id": 10116, "disease": "", "pathway": " (rno:301114)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18928449", "class_list": "", "function": "Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005347 ATP transmembrane transporter activity;GO:0015217 ADP transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0015866 ADP transport;GO:0015867 ATP transport;GO:0140021 mitochondrial ADP transmembrane transport;GO:1990544 mitochondrial ATP transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B8ZHC9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HJX2-1", "uniprot_id": [ { "id": "LRB3A_RAT", "url": "https://www.uniprot.org/uniprot/C0HJX2", "type": "external" } ], "mass": 82704.0, "length": 744, "protein_name": "Leukocyte immunoglobulin-like receptor subfamily B member 3A", "gene_name": "Lilrb3a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lilrb3a", "gene_names_refseq": "", "protein_names_uniprotkb": "Leukocyte immunoglobulin-like receptor subfamily B member 3A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:683463)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as receptor for class I MHC antigens. Becomes activated upon coligation with immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0001540 amyloid-beta binding;GO:0032396 inhibitory MHC class I receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0007611 learning or memory;GO:1900271 regulation of long-term synaptic potentiation;GO:0001782 B cell homeostasis;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "C0HJX2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HJX3-1", "uniprot_id": [ { "id": "LRB3B_RAT", "url": "https://www.uniprot.org/uniprot/C0HJX3", "type": "external" } ], "mass": 82704.0, "length": 744, "protein_name": "Leukocyte immunoglobulin-like receptor subfamily B member 3B", "gene_name": "Lilrb3b", "organism": "Rat", "refseq_name": "leukocyte immunoglobulin-like receptor subfamily B member 3A precursor", "refseq_ac": [ { "id": "NP_001300853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300853", "type": "external" } ], "gene_names_uniprotkb": "Lilrb3b", "gene_names_refseq": "Lilrb3a; Lilrb3b; Lilrb3l; Pir-A1; Pirb", "protein_names_uniprotkb": "Leukocyte immunoglobulin-like receptor subfamily B member 3B", "protein_names_refseq": "Leukocyte immunoglobulin-like receptor subfamily B member 3A; Leukocyte immunoglobulin-like receptor subfamily B member 3B; leukocyte immunoglobulin-like receptor subfamily B member 3-like; leukocyte immunoglobulin-like receptor subfamily B member 3A precursor; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3A; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3B", "tax_id": 10116, "disease": "", "pathway": " (rno:683463)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0001540 amyloid-beta binding;GO:0032396 inhibitory MHC class I receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0007611 learning or memory;GO:1900271 regulation of long-term synaptic potentiation;GO:0001782 B cell homeostasis;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "C0HJX3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D2KX21-1", "uniprot_id": [ { "id": "PLAT1_RAT", "url": "https://www.uniprot.org/uniprot/D2KX21", "type": "external" } ], "mass": 18521.0, "length": 167, "protein_name": "Phospholipase A and acyltransferase 1", "gene_name": "Plaat1", "organism": "Rat", "refseq_name": "phospholipase A and acyltransferase 1", "refseq_ac": [ { "id": "NP_001099341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099341", "type": "external" } ], "gene_names_uniprotkb": "Plaat1; A-C1; Hrasls; Hrasrs; RLP-2; rCG_36537", "gene_names_refseq": "A-C1; HRSL1; Hrasls; Plaat1; RLP-2", "protein_names_uniprotkb": "Phospholipase A and acyltransferase 1; 2.3.1.-; 3.1.1.32; 3.1.1.4; HRAS-like suppressor 1; HRSL1; Phospholipid-metabolizing enzyme A-C1; RLP-2; Rat LRAT-like protein-2", "protein_names_refseq": "HRAS-like suppressor 1; LRAT-like protein-2; phospholipase A and acyltransferase 1; phospholipid-metabolizing enzyme A-C1", "tax_id": 10116, "disease": "", "pathway": " (rno:288025); (R-RNO-1482839)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17158102;21880860", "class_list": "", "function": "A possible enzyme activity of A-C1, [RefSeq, PubMed]; Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0016410 N-acyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:1903008 organelle disassembly;GO:0007031 peroxisome organization;GO:0016042 lipid catabolic process;GO:0046470 phosphatidylcholine metabolic process;GO:0046485 ether lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D2KX21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z7Z4-1", "uniprot_id": [ { "id": "D3Z7Z4_RAT", "url": "https://www.uniprot.org/uniprot/D3Z7Z4", "type": "external" } ], "mass": 41936.0, "length": 371, "protein_name": "Lipoyl amidotransferase LIPT1, mitochondrial", "gene_name": "Lipt1", "organism": "Rat", "refseq_name": "lipoyl amidotransferase LIPT1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001101682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101682", "type": "external" } ], "gene_names_uniprotkb": "Lipt1", "gene_names_refseq": "Lipt1", "protein_names_uniprotkb": "Lipoyl amidotransferase LIPT1, mitochondrial; 2.3.1.200; Lipoate biosynthesis protein; Lipoate-protein ligase; Lipoyl ligase; Lipoyltransferase 1", "protein_names_refseq": "lipoyl amidotransferase LIPT1, mitochondrial precursor; lipoyl amidotransferase LIPT1, mitochondrial; lipoyltransferase 1, mitochondrial", "tax_id": 10116, "disease": "Leigh disease (Disease Ontology:DOID:3652)", "pathway": " (rno:316342); (R-RNO-9857492)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "Lipoyl amidotransferase that catalyzes the transfer of lipoyl moieties from lipoyl-protein H of the glycine cleavage system (lipoyl-GCSH) to E2 subunits of the pyruvate dehydrogenase complex (PDCE2). Unable to catalyze the transfer of octanoyl from octanoyl-GCSH to PDCE2. In vitro, it is also able to catalyze the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes but this reaction may not be physiologically relevant., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.200", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.200", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "2.3.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.61", "type": "external" } ], "go_molecular_function": "GO:0016410 N-acyltransferase activity;GO:0017118 lipoyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0009249 protein lipoylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z7Z4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z851-1", "uniprot_id": [ { "id": "D3Z851_RAT", "url": "https://www.uniprot.org/uniprot/D3Z851", "type": "external" } ], "mass": 49061.0, "length": 434, "protein_name": "F-box and leucine-rich repeat protein 21", "gene_name": "Fbxl21", "organism": "Rat", "refseq_name": "F-box/LRR-repeat protein 21", "refseq_ac": [ { "id": "NP_001278337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278337", "type": "external" } ], "gene_names_uniprotkb": "Fbxl21; Fbxl3-ps1", "gene_names_refseq": "Fbxl21; Fbxl3-ps1; Fbxl3p", "protein_names_uniprotkb": "F-box and leucine-rich repeat protein 21", "protein_names_refseq": "F-box and leucine-rich repeat protein 3, pseudogene 1; F-box/LRR-repeat protein 21", "tax_id": 10116, "disease": "", "pathway": " (rno:306750); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0048511 rhythmic process;GO:0043153 entrainment of circadian clock by photoperiod;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z851-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8D9-1", "uniprot_id": [ { "id": "MD2L2_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8D9", "type": "external" } ], "mass": 24402.0, "length": 211, "protein_name": "Mitotic spindle assembly checkpoint protein MAD2B", "gene_name": "Mad2l2", "organism": "Rat", "refseq_name": "mitotic spindle assembly checkpoint protein MAD2B isoform 2", "refseq_ac": [ { "id": "NP_001012106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012106", "type": "external" } ], "gene_names_uniprotkb": "Mad2l2", "gene_names_refseq": "Mad2l2", "protein_names_uniprotkb": "Mitotic spindle assembly checkpoint protein MAD2B; MAD2-like protein 2; Mitotic arrest deficient 2-like protein 2", "protein_names_refseq": "MAD2 mitotic arrest deficient-like 2; MAD2-like protein 2; mitotic arrest deficient 2-like protein 2; mitotic spindle assembly checkpoint protein MAD2B isoform 2; mitotic spindle assembly checkpoint protein MAD2B", "tax_id": 10116, "disease": "Fanconi anemia complementation group V (Disease Ontology:DOID:0111080)", "pathway": " (rno:313702); (R-RNO-110312); (R-RNO-5655862); (R-RNO-5656121); (R-RNO-5656169)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "24444371;25651564;27488450;27957796", "class_list": "", "function": "Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation., [UniProtKB, UniProtKB]; Hyperglycaemia induced neuronal apoptosis through inducing expression of MAD2B, which represents a novel mechanism of diabetic encephalopathy., [RefSeq, PubMed]; Skp2, a confirmed APC/C-CDH1 substrate and E-cadherin destroyer, was increased in TGF-beta1-treated proximal tubular epithelial cells, which could be blocked by MAD2B depletion., [RefSeq, PubMed]; That MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression, [RefSeq, PubMed]; This study demonstrates that AMPK acts as a key regulator of MAD2B expression, suggesting that activation of AMPK signalling might be crucial for the treatment of high glucose-induced neuronal injury, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PPH8", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3Z8D9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8E0-1", "uniprot_id": [ { "id": "D3Z8E0_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8E0", "type": "external" } ], "mass": 83724.0, "length": 740, "protein_name": "Ribosomal protein S6 kinase", "gene_name": "Rps6ka3", "organism": "Rat", "refseq_name": "ribosomal protein S6 kinase alpha-3", "refseq_ac": [ { "id": "NP_001178933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178933", "type": "external" } ], "gene_names_uniprotkb": "Rps6ka3", "gene_names_refseq": "RGD1563860; Rps6ka3", "protein_names_uniprotkb": "Ribosomal protein S6 kinase; 2.7.11.1", "protein_names_refseq": "ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase polypeptide 3", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability 19 (Disease Ontology:DOID:0112019); intellectual disability (Disease Ontology:DOID:1059); Coffin-Lowry syndrome (Disease Ontology:DOID:3783)", "pathway": " (rno:501560); (R-RNO-198753); (R-RNO-199920); (R-RNO-2559582); (R-RNO-442742); (R-RNO-444257); (R-RNO-881907)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0038202 TORC1 signaling;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z8E0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z8E2-1", "uniprot_id": [ { "id": "D3Z8E2_RAT", "url": "https://www.uniprot.org/uniprot/D3Z8E2", "type": "external" } ], "mass": 89482.0, "length": 775, "protein_name": "Semaphorin 3E", "gene_name": "Sema3e", "organism": "Rat", "refseq_name": "semaphorin-3E precursor", "refseq_ac": [ { "id": "NP_001100049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100049", "type": "external" } ], "gene_names_uniprotkb": "Sema3e", "gene_names_refseq": "Sema3e", "protein_names_uniprotkb": "Semaphorin 3E", "protein_names_refseq": "sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; semaphorin-3E precursor", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:296789); (R-RNO-416700)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "30007159", "class_list": "", "function": "Study found that depletion of Sema3E/PlexinD1 signaling with lentivirus-mediated PlexinD1-specific-shRNA improves tissue survival and functional outcome following stroke. 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RGD1307983", "protein_names_uniprotkb": "SOSS complex subunit C; SOSS-C; SSB-interacting protein 1; Sensor of single-strand DNA complex subunit C; Sensor of ssDNA subunit C; Single-stranded DNA-binding protein-interacting protein 1", "protein_names_refseq": "SOSS complex subunit C", "tax_id": 10116, "disease": "", "pathway": " (rno:298032)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. 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Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. 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"id": "D3Z946_RAT", "url": "https://www.uniprot.org/uniprot/D3Z946", "type": "external" } ], "mass": 28399.0, "length": 253, "protein_name": "Transmembrane protein 70", "gene_name": "Tmem70", "organism": "Rat", "refseq_name": "transmembrane protein 70, mitochondrial", "refseq_ac": [ { "id": "NP_001102728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102728", "type": "external" } ], "gene_names_uniprotkb": "Tmem70", "gene_names_refseq": "RGD1566224; Tmem70", "protein_names_uniprotkb": "Transmembrane protein 70", "protein_names_refseq": "transmembrane protein 70, mitochondrial", "tax_id": 10116, "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 2 (Disease Ontology:DOID:0060331)", "pathway": " (rno:500384)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27914986", "class_list": "", "function": "The effect of thioacetamide on neoplastic liver changes and hypermethylation and downregulation of proteins, especially Tmem70 and Ube2e2, are 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containing 4; stAR-related lipid transfer protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:291699); (R-RNO-196108)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0070859 positive regulation of bile acid biosynthetic process;GO:0032367 intracellular cholesterol transport;GO:0070508 cholesterol import;GO:0090205 positive regulation of cholesterol metabolic process;GO:0010879 cholesterol transport involved in cholesterol storage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z9I9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9M3-1", "uniprot_id": [ { "id": "GLIAD_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9M3", "type": "external" } ], "mass": 12547.0, "length": 109, "protein_name": "Gliadoralin-A", "gene_name": "Glal", "organism": "Rat", "refseq_name": "gliadoralin-A precursor", "refseq_ac": [ { "id": "NP_001102119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102119", "type": "external" } ], "gene_names_uniprotkb": "Glal; RGD1306750", "gene_names_refseq": "Glal; RGD1306750", "protein_names_uniprotkb": "Gliadoralin-A", "protein_names_refseq": "gliadoralin-A precursor; gliadoralin-A", "tax_id": 10116, "disease": "", "pathway": " (rno:362451)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23637100", "class_list": "", "function": "May play a role in the formation of the protective mucosal protein pellicle involved in the reinforcement and protection of oral mucosal epithelial surface., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3Z9M3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3Z9X9-1", "uniprot_id": [ { "id": "D3Z9X9_RAT", "url": "https://www.uniprot.org/uniprot/D3Z9X9", "type": "external" } ], "mass": 12557.0, "length": 109, "protein_name": "Prostate and testis expressed 7", "gene_name": "Pate7", "organism": "Rat", "refseq_name": "uncharacterized protein LOC363043 precursor", "refseq_ac": [ { "id": "NP_001102228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102228", "type": "external" } ], "gene_names_uniprotkb": "Pate7; RGD1304554", "gene_names_refseq": "Pate-E; Pate7; RGD1304554", "protein_names_uniprotkb": "Prostate and testis expressed 7", "protein_names_refseq": "prostate and testis expressed protein E; uncharacterized protein LOC363043 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:363043)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3Z9X9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZA67-1", "uniprot_id": [ { "id": "D3ZA67_RAT", "url": "https://www.uniprot.org/uniprot/D3ZA67", "type": "external" } ], "mass": 27305.0, "length": 254, "protein_name": "BARX homeobox 1", "gene_name": "Barx1", "organism": "Rat", "refseq_name": "homeobox protein BarH-like 1", "refseq_ac": [ { "id": "NP_001102350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102350", "type": "external" } ], "gene_names_uniprotkb": "Barx1", "gene_names_refseq": "Barx1", "protein_names_uniprotkb": "BARX homeobox 1", "protein_names_refseq": "BarH-like homeobox 1; homeobox protein BarH-like 1", "tax_id": 10116, "disease": "", "pathway": " (rno:364680)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007267 cell-cell signaling;GO:0030855 epithelial cell differentiation;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZA67-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAC5-1", "uniprot_id": [ { "id": "D3ZAC5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAC5", "type": "external" } ], "mass": 26582.0, "length": 241, "protein_name": "DnaJ heat shock protein family (Hsp40) member B3", "gene_name": "Dnajb3", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily B member 3", "refseq_ac": [ { "id": "NP_001102866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102866", "type": "external" } ], "gene_names_uniprotkb": "Dnajb3", "gene_names_refseq": "Dnajb3", "protein_names_uniprotkb": "DnaJ heat shock protein family (Hsp40) member B3", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 3; dnaJ homolog subfamily B member 3", "tax_id": 10116, "disease": "autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305)", "pathway": " (rno:680216)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0030544 Hsp70 protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZAC5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAL8-1", "uniprot_id": [ { "id": "LRRT3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAL8", "type": "external" } ], "mass": 66030.0, "length": 582, "protein_name": "Leucine-rich repeat transmembrane neuronal protein 3", "gene_name": "Lrrtm3", "organism": "Rat", "refseq_name": "leucine-rich repeat transmembrane neuronal protein 3 precursor", "refseq_ac": [ { "id": "NP_001099857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099857", "type": "external" } ], "gene_names_uniprotkb": "Lrrtm3", "gene_names_refseq": "Lrrtm3", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane neuronal protein 3", "protein_names_refseq": "leucine-rich repeat transmembrane neuronal protein 3 precursor; leucine-rich repeat transmembrane neuronal protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:294380); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19285470;38843836", "class_list": "", "function": "May play a role in the development and maintenance of the nervous system (By similarity). Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0050808 synapse organization;GO:1902004 positive regulation of amyloid-beta formation;GO:0051965 positive regulation of synapse assembly;GO:1905606 regulation of presynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZAL8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZAP3-1", "uniprot_id": [ { "id": "MAP10_RAT", "url": "https://www.uniprot.org/uniprot/D3ZAP3", "type": "external" } ], "mass": 96280.0, "length": 888, "protein_name": "Microtubule-associated protein 10", "gene_name": "Map10", "organism": "Rat", "refseq_name": "microtubule-associated protein 10", "refseq_ac": [ { "id": "NP_001264320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264320", "type": "external" } ], "gene_names_uniprotkb": "Map10", "gene_names_refseq": "Map10; RGD1308644", "protein_names_uniprotkb": "Microtubule-associated protein 10; Microtubule regulator of 120 KDa", "protein_names_refseq": "microtubule regulator of 120 KDa; microtubule-associated protein 10", "tax_id": 10116, "disease": "", "pathway": " (rno:307948)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0030496 midbody;GO:0005881 cytoplasmic microtubule;GO:0097431 mitotic spindle pole;GO:1990023 mitotic spindle midzone", "go_biological_process": "GO:0051301 cell division;GO:0032886 regulation of microtubule-based process;GO:0032467 positive regulation of cytokinesis;GO:0051256 mitotic spindle midzone assembly;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZAP3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZBD1-1", "uniprot_id": [ { "id": "D3ZBD1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZBD1", "type": "external" } ], "mass": 28869.0, "length": 262, "protein_name": "R-spondin-1", "gene_name": "Rspo1", "organism": "Rat", "refseq_name": "R-spondin-1 precursor", "refseq_ac": [ { "id": "NP_001101450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101450", "type": "external" } ], "gene_names_uniprotkb": "Rspo1", "gene_names_refseq": "RGD1565558; Rspo1", "protein_names_uniprotkb": "R-spondin-1; Roof plate-specific spondin-1", "protein_names_refseq": "R-spondin-1 precursor", "tax_id": 10116, "disease": "type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:313589); (R-RNO-4641263)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "24280058", "class_list": "", "function": "Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1., [UniProtKB, UniProtKB, UniProtKB]; These data indicate that Rspo1 and Rspo3 and their receptor LGR4 form novel circuits in the brain to regulate energy homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0060255 regulation of macromolecule metabolic process;GO:1903999 negative regulation of eating behavior;GO:2000254 regulation of male germ cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZBD1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZBM7-1", "uniprot_id": [ { "id": "HACE1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZBM7", "type": "external" } ], "mass": 102159.0, "length": 909, "protein_name": "E3 ubiquitin-protein ligase HACE1", "gene_name": "Hace1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase HACE1", "refseq_ac": [ { "id": "NP_001102009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102009", "type": "external" } ], "gene_names_uniprotkb": "Hace1", "gene_names_refseq": "Hace1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HACE1; 2.3.2.26; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1", "protein_names_refseq": "E3 ubiquitin-protein ligase HACE1; HECT-type E3 ubiquitin transferase HACE1", "tax_id": 10116, "disease": "", "pathway": " (rno:361866); (R-RNO-983168); (R-RNO-9958825)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15254018;38332367", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases (By similarity). Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion (By similarity). Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division (By similarity). Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (By similarity). May also act as a transcription regulator via its interaction with RARB (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB., [UniProtKB, UniProtKB, UniProtKB]; Expression analysis of the human Hace1 ortholog and demonstration of its ubiquitin ligase activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZBM8", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0031267 small GTPase binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0030334 regulation of cell migration;GO:0061025 membrane fusion;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZBM7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZBN0-1", "uniprot_id": [ { "id": "H15_RAT", "url": "https://www.uniprot.org/uniprot/D3ZBN0", "type": "external" } ], "mass": 22649.0, "length": 222, "protein_name": "Histone H1.5", "gene_name": "H1-5", "organism": "Rat", "refseq_name": "histone H1.5", "refseq_ac": [ { "id": "NP_001102887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102887", "type": "external" } ], "gene_names_uniprotkb": "H1-5; H1f5; HIf5; Hist1h1b", "gene_names_refseq": "H1-5; H1f5; Hist1h1b", "protein_names_uniprotkb": "Histone H1.5", "protein_names_refseq": "histone H1.5; histone cluster 1 H1 family member b; histone cluster 1, H1b", "tax_id": 10116, "disease": "", "pathway": " (rno:680522); (R-RNO-140342); (R-RNO-2559584)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0003690 double-stranded DNA binding;GO:0031490 chromatin DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000791 euchromatin;GO:0000792 heterochromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0050821 protein stabilization;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZBN0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZCG9-1", "uniprot_id": [ { "id": "D3ZCG9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZCG9", "type": "external" } ], "mass": 117014.0, "length": 1052, "protein_name": "Integrin alpha-3", "gene_name": "Itga3", "organism": "Rat", "refseq_name": "integrin alpha-3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001101762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101762", "type": "external" } ], "gene_names_uniprotkb": "Itga3", "gene_names_refseq": "Itga3", "protein_names_uniprotkb": "Integrin alpha-3; CD49 antigen-like family member C; Galactoprotein B3; VLA-3 subunit alpha", "protein_names_refseq": "integrin alpha-3 isoform 1 precursor; integrin, alpha 3", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); glomerulonephritis (Disease Ontology:DOID:2921); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:360606); (R-RNO-210991); (R-RNO-216083); (R-RNO-8874081)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "28701000", "class_list": "", "function": "Decreased expression of Itga3, Itga6, and Itga8 in the pulmonary mesenchyme may lead to disruptions in airway branching morphogenesis, thus contributing to pulmonary hypoplasia in the nitrofen-induced congenital diaphragmatic hernia model., [RefSeq, PubMed]; Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0019904 protein domain specific binding;GO:0046982 protein heterodimerization activity;GO:0005518 collagen binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0072006 nephron development;GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZCG9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZCH1-1", "uniprot_id": [ { "id": "D3ZCH1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZCH1", "type": "external" } ], "mass": 233253.0, "length": 2047, "protein_name": "Ankyrin repeat domain 12", "gene_name": "Ankrd12", "organism": "Rat", "refseq_name": "ankyrin repeat domain-containing protein 12", "refseq_ac": [ { "id": "NP_001101708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101708", "type": "external" } ], "gene_names_uniprotkb": "Ankrd12", "gene_names_refseq": "Ankrd12", "protein_names_uniprotkb": "Ankyrin repeat domain 12", "protein_names_refseq": "ankyrin repeat domain-containing protein 12-like; ankyrin repeat domain-containing protein 12", "tax_id": 10116, "disease": "", "pathway": " (rno:316775)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZCH1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZD23-1", "uniprot_id": [ { "id": "D3ZD23_RAT", "url": "https://www.uniprot.org/uniprot/D3ZD23", "type": "external" } ], "mass": 62752.0, "length": 558, "protein_name": "ATP binding cassette subfamily E member 1", "gene_name": "Abce1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Abce1", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP binding cassette subfamily E member 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "breast carcinoma (Disease Ontology:DOID:3459); lung adenocarcinoma (Disease Ontology:DOID:3910); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0060698 endoribonuclease inhibitor activity;GO:0017111 ribonucleoside triphosphate phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006415 translational termination;GO:0060702 negative regulation of endoribonuclease activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZD23-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZD88-1", "uniprot_id": [ { "id": "D3ZD88_RAT", "url": "https://www.uniprot.org/uniprot/D3ZD88", "type": "external" } ], "mass": 95464.0, "length": 852, "protein_name": "B-cell receptor CD22", "gene_name": "Cd22", "organism": "Rat", "refseq_name": "B-cell receptor CD22 precursor", "refseq_ac": [ { "id": "NP_001100973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100973", "type": "external" } ], "gene_names_uniprotkb": "Cd22", "gene_names_refseq": "Cd22", "protein_names_uniprotkb": "B-cell receptor CD22; Sialic acid-binding Ig-like lectin 2", "protein_names_refseq": "B-cell receptor CD22 precursor; B-cell receptor CD22; CD22 antigen", "tax_id": 10116, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745)", "pathway": " (rno:308501); (R-RNO-198933); (R-RNO-5690714); (R-RNO-983695)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow. Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration. Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling. If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042609 CD4 receptor binding;GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0055037 recycling endosome;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050849 negative regulation of calcium-mediated signaling;GO:0007155 cell adhesion;GO:0030100 regulation of endocytosis;GO:0042113 B cell activation;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZD88-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZD89-1", "uniprot_id": [ { "id": "D3ZD89_RAT", "url": "https://www.uniprot.org/uniprot/D3ZD89", "type": "external" } ], "mass": 101010.0, "length": 865, "protein_name": "N(alpha)-acetyltransferase 15, NatA auxiliary subunit", "gene_name": "Naa15", "organism": "Rat", "refseq_name": "N-alpha-acetyltransferase 15, NatA auxiliary subunit", "refseq_ac": [ { "id": "NP_001101144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101144", "type": "external" } ], "gene_names_uniprotkb": "Naa15", "gene_names_refseq": "Naa15; Narg1", "protein_names_uniprotkb": "N(alpha)-acetyltransferase 15, NatA auxiliary subunit", "protein_names_refseq": "N-alpha-acetyltransferase 15, NatA auxiliary subunit; NMDA receptor regulated 1; NMDA receptor-regulated gene 1", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant intellectual developmental disorder 50 (Disease Ontology:DOID:0080233); intellectual disability (Disease Ontology:DOID:1059); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:310399)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding;GO:0010698 acetyltransferase activator activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZD89-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZDM6-1", "uniprot_id": [ { "id": "D3ZDM6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZDM6", "type": "external" } ], "mass": 56613.0, "length": 501, "protein_name": "cyclin-dependent kinase", "gene_name": "Cdk19", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 19", "refseq_ac": [ { "id": "NP_001101104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101104", "type": "external" } ], "gene_names_uniprotkb": "Cdk19", "gene_names_refseq": "Cdc2l6; Cdk11; Cdk19", "protein_names_uniprotkb": "cyclin-dependent kinase; 2.7.11.22", "protein_names_refseq": "cell division cycle 2-like 6 (CDK8-like); cell division protein kinase 19; cyclin-dependent kinase (CDC2-like) 11; cyclin-dependent kinase 19", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 87 (Disease Ontology:DOID:0112221)", "pathway": " (rno:309804)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:1990508 CKM complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZDM6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZDT0-1", "uniprot_id": [ { "id": "D3ZDT0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZDT0", "type": "external" } ], "mass": 38021.0, "length": 350, "protein_name": "Kelch domain-containing protein 9", "gene_name": "Klhdc9", "organism": "Rat", "refseq_name": "kelch domain-containing protein 9", "refseq_ac": [ { "id": "NP_001101820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101820", "type": "external" } ], "gene_names_uniprotkb": "Klhdc9", "gene_names_refseq": "Klhdc9; RGD1561025", "protein_names_uniprotkb": "Kelch domain-containing protein 9", "protein_names_refseq": "kelch domain-containing protein 9", "tax_id": 10116, "disease": "", "pathway": " (rno:360878)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030332 cyclin binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZDT0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZDW9-1", "uniprot_id": [ { "id": "D3ZDW9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZDW9", "type": "external" } ], "mass": 63022.0, "length": 598, "protein_name": "Docking protein 7", "gene_name": "Dok7", "organism": "Rat", "refseq_name": "protein Dok-7 isoform X1", "refseq_ac": [ { "id": "XP_017454694", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017454694", "type": "external" } ], "gene_names_uniprotkb": "Dok7", "gene_names_refseq": "Dok7; RGD1566416", "protein_names_uniprotkb": "Docking protein 7", "protein_names_refseq": "protein Dok-7 isoform X1", "tax_id": 10116, "disease": "congenital myasthenic syndrome 10 (Disease Ontology:DOID:0110668); fetal akinesia deformation sequence syndrome 3 (Disease Ontology:DOID:0111376)", "pathway": " (rno:305448)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0035591 signaling adaptor activity;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0031594 neuromuscular junction;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0035022 positive regulation of Rac protein signal transduction;GO:0007167 enzyme-linked receptor protein signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0007528 neuromuscular junction development;GO:0061098 positive regulation of protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZDW9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEM1-1", "uniprot_id": [ { "id": "D3ZEM1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEM1", "type": "external" } ], "mass": 42731.0, "length": 399, "protein_name": "Homeobox protein aristaless-like 4", "gene_name": "Alx4", "organism": "Rat", "refseq_name": "homeobox protein aristaless-like 4", "refseq_ac": [ { "id": "NP_001100023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100023", "type": "external" } ], "gene_names_uniprotkb": "Alx4", "gene_names_refseq": "Alx4", "protein_names_uniprotkb": "Homeobox protein aristaless-like 4", "protein_names_refseq": "aristaless 4; aristaless-like homeobox 4; homeobox protein aristaless-like 4", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); parietal foramina (Disease Ontology:DOID:0060285); frontonasal dysplasia 2 (Disease Ontology:DOID:0081046); non-syndromic X-linked intellectual disability 1 (Disease Ontology:DOID:0112038); lung cancer (Disease Ontology:DOID:1324); craniosynostosis (Disease Ontology:DOID:2340); gastric adenocarcinoma (Disease Ontology:DOID:3717); lung adenocarcinoma (Disease Ontology:DOID:3910); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:296511)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development;GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZEM1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEM3-1", "uniprot_id": [ { "id": "D3ZEM3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEM3", "type": "external" } ], "mass": 25644.0, "length": 222, "protein_name": "TGFB-induced factor homeobox 2-like, X-linked 2", "gene_name": "Tgif2lx2", "organism": "Rat", "refseq_name": "TGFB-induced factor homeobox 2-like, X-linked 2", "refseq_ac": [ { "id": "NP_001420361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001420361", "type": "external" } ], "gene_names_uniprotkb": "Tgif2lx2", "gene_names_refseq": "RGD1561826; Tgif2lx2", "protein_names_uniprotkb": "TGFB-induced factor homeobox 2-like, X-linked 2", "protein_names_refseq": "TGFB-induced factor homeobox 2-like, X-linked 2; homeobox protein TGIF2LX", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0010470 regulation of gastrulation;GO:1902871 positive regulation of amacrine cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0038092 nodal signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZEM3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZEM7-1", "uniprot_id": [ { "id": "D3ZEM7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZEM7", "type": "external" } ], "mass": 74788.0, "length": 671, "protein_name": "Solute carrier family 5 member 1 like 1", "gene_name": "Slc5a1l1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc5a1l1; RGD1563815", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 5 member 1 like 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZEM7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZES2-1", "uniprot_id": [ { "id": "D3ZES2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZES2", "type": "external" } ], "mass": 17977.0, "length": 158, "protein_name": "Trafficking protein particle complex subunit 6B", "gene_name": "Trappc6b", "organism": "Rat", "refseq_name": "trafficking protein particle complex subunit 6B", "refseq_ac": [ { "id": "NP_001100203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100203", "type": "external" } ], "gene_names_uniprotkb": "Trappc6b", "gene_names_refseq": "RGD1309325; Trappc6b", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 6B", "protein_names_refseq": "trafficking protein particle complex 6B; trafficking protein particle complex subunit 6B", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy (Disease Ontology:DOID:0060934)", "pathway": " (rno:299075); (R-RNO-204005); (R-RNO-8876198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005801 cis-Golgi network;GO:0005802 trans-Golgi network;GO:0030008 TRAPP complex;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007399 nervous system development;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZES2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZF56-1", "uniprot_id": [ { "id": "D3ZF56_RAT", "url": "https://www.uniprot.org/uniprot/D3ZF56", "type": "external" } ], "mass": 25658.0, "length": 230, "protein_name": "Transmembrane protein 134", "gene_name": "Tmem134", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmem134", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein 134", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:361695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, 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"protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFS3-1", "uniprot_id": [ { "id": "D3ZFS3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFS3", "type": "external" } ], "mass": 73378.0, "length": 670, "protein_name": "Zinc finger and BTB domain-containing protein 5", "gene_name": "Zbtb5", "organism": "Rat", "refseq_name": "zinc finger and BTB domain-containing protein 5", "refseq_ac": [ { "id": "NP_001100127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100127", "type": "external" } ], "gene_names_uniprotkb": "Zbtb5", "gene_names_refseq": "Zbtb5", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 5", "protein_names_refseq": "zinc finger and BTB domain-containing protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:298084)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZFS3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFY0-1", "uniprot_id": [ { "id": "D3ZFY0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFY0", "type": "external" } ], "mass": 42893.0, "length": 392, "protein_name": "selenide, water dikinase", "gene_name": "Sephs1", "organism": "Rat", "refseq_name": "selenide, water dikinase 1", "refseq_ac": [ { "id": "NP_001098100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098100", "type": "external" } ], "gene_names_uniprotkb": "Sephs1", "gene_names_refseq": "Sephs1", "protein_names_uniprotkb": "selenide, water dikinase; 2.7.9.3; Selenium donor protein 1; Selenophosphate synthase 1", "protein_names_refseq": "selenide, water dikinase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:291314)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;38105759", "class_list": "", "function": "Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression. The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif. Within the complex, SEPHS1, recognizes and binds the backbone of zinc fingers of transcription factors in a sequence-independent manner via its arginine clamp, enhancing their DNA-binding stability. Plays an essential role in redox homeostasis. May also be involved in selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP. Its role in selenocysteine biosynthesis is however unclear and several studies suggest that it does not act as a selenophosphate synthase in vivo or plays an non-essential role. Required for cardiac differentiation., [UniProtKB, UniProtKB]; SEPHS1 attenuates intervertebral disc degeneration by delaying nucleus pulposus cell senescence through the Hippo-Yap/Taz pathway., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.9.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.9.3", "type": "external" } ], "go_molecular_function": "GO:0004756 selenide, water dikinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0016260 selenocysteine biosynthetic process;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZFY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZG07-1", "uniprot_id": [ { "id": "D3ZG07_RAT", "url": "https://www.uniprot.org/uniprot/D3ZG07", "type": "external" } ], "mass": 9128.0, "length": 80, "protein_name": "U6 snRNA-associated Sm-like protein LSm6", "gene_name": "Lsm6", "organism": "Rat", "refseq_name": "U6 snRNA-associated Sm-like protein LSm6", "refseq_ac": [ { "id": "NP_001119557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119557", "type": "external" } ], "gene_names_uniprotkb": "Lsm6; LOC100360750; Lsm6l1", "gene_names_refseq": "Lsm6; RGD1561937", "protein_names_uniprotkb": "U6 snRNA-associated Sm-like protein LSm6", "protein_names_refseq": "LSM6 U6 small nuclear RNA and mRNA degradation associated; LSM6 homolog, U6 small nuclear RNA associated; Sm protein F; U6 snRNA-associated Sm-like protein LSm6; rCG63582-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100360750); (rno:498934); (R-RNO-430039)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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"external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase 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nucleus;GO:0010498 proteasomal protein catabolic process;GO:0000724 double-strand break repair via homologous recombination;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZHW9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZIG3-1", "uniprot_id": [ { "id": "D3ZIG3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZIG3", "type": "external" } ], "mass": 57720.0, "length": 503, "protein_name": "Zinc finger protein 3", "gene_name": "Zfp3", "organism": "Rat", "refseq_name": "zinc finger protein 3 homolog", "refseq_ac": [ { "id": "NP_001102504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102504", "type": "external" } ], "gene_names_uniprotkb": "Zfp3", "gene_names_refseq": "RGD1565881; Zfp3", "protein_names_uniprotkb": "Zinc finger protein 3", "protein_names_refseq": "zinc finger protein 3 homolog", "tax_id": 10116, 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"0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZIH3-1", "uniprot_id": [ { "id": "D3ZIH3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZIH3", "type": "external" } ], "mass": 34664.0, "length": 326, "protein_name": "Hes-related family bHLH transcription factor with YRPW motif-like", "gene_name": "Heyl", "organism": "Rat", "refseq_name": "hairy/enhancer-of-split related with YRPW motif-like protein", "refseq_ac": [ { "id": "NP_001101447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101447", "type": "external" } ], "gene_names_uniprotkb": "Heyl", "gene_names_refseq": "Heyl", "protein_names_uniprotkb": "Hes-related family bHLH transcription factor with YRPW motif-like", "protein_names_refseq": "hairy/enhancer-of-split related with YRPW motif-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:313575)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", 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"glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0003208 cardiac ventricle morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZIH3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZIH4-1", "uniprot_id": [ { "id": "D3ZIH4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZIH4", "type": "external" } ], "mass": 48572.0, "length": 431, "protein_name": "F-box only protein 4", "gene_name": "Fbxo4", "organism": "Rat", "refseq_name": "F-box only protein 4", "refseq_ac": [ { "id": "NP_001101142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101142", "type": "external" } ], "gene_names_uniprotkb": "Fbxo4", "gene_names_refseq": "Fbxo4", "protein_names_uniprotkb": "F-box only protein 4", "protein_names_refseq": "F-box only protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:310363); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of cyclin-D1 (CCND1) and its subsequent proteasomal degradation. However, it does not act as a major regulator of CCND1 stability during the G1/S transition. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0019725 cellular homeostasis;GO:1900181 negative regulation of protein localization to nucleus;GO:0010608 post-transcriptional regulation of gene expression;GO:0000723 telomere maintenance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZIH4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZII8-1", "uniprot_id": [ { "id": "D3ZII8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZII8", "type": "external" } ], "mass": 47068.0, "length": 417, "protein_name": "Protein-lysine N-trimethyltransferase SMYD5", "gene_name": "Smyd5", "organism": "Rat", "refseq_name": "histone-lysine N-trimethyltransferase SMYD5", "refseq_ac": [ { "id": "NP_001101340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101340", "type": "external" } ], "gene_names_uniprotkb": "Smyd5", "gene_names_refseq": "Smyd5", "protein_names_uniprotkb": "Protein-lysine N-trimethyltransferase SMYD5; 2.1.1.359; 2.1.1.372; Protein NN8-4AG; Retinoic acid-induced protein 15; SET and MYND domain-containing protein 5; [histone H3]-lysine20 N-trimethyltransferase SMYD5; [histone H4]-lysine36 N-trimethyltransferase SMYD5", "protein_names_refseq": "SET and MYND domain containing 5; SET and MYND domain-containing protein 5; histone-lysine N-trimethyltransferase SMYD5", "tax_id": 10116, "disease": "", "pathway": " (rno:312503)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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"url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016279 protein-lysine N-methyltransferase activity;GO:0042799 histone H4K20 methyltransferase activity;GO:0140955 histone H3K36 trimethyltransferase activity;GO:0140943 histone H4K20 trimethyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045814 negative regulation of gene expression, epigenetic;GO:0032259 methylation;GO:2000035 regulation of stem cell division;GO:2000736 regulation of stem cell differentiation;GO:0141005 transposable element silencing by heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZII8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZJ15-1", "uniprot_id": [ { "id": "D3ZJ15_RAT", "url": "https://www.uniprot.org/uniprot/D3ZJ15", "type": "external" } ], "mass": 24813.0, "length": 226, "protein_name": "Transmembrane 4 L six family member 20", "gene_name": "Tm4sf20", "organism": "Rat", "refseq_name": "transmembrane 4 L6 family member 20", "refseq_ac": [ { "id": "NP_001103088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103088", "type": "external" } ], "gene_names_uniprotkb": "Tm4sf20", "gene_names_refseq": "Tm4sf20", "protein_names_uniprotkb": "Transmembrane 4 L six family member 20", "protein_names_refseq": "transmembrane 4 L6 family member 20-like; transmembrane 4 L6 family member 20", "tax_id": 10116, "disease": "specific language impairment (Disease Ontology:DOID:0060244)", "pathway": " (rno:691066)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045861 negative regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZJ15-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZJ70-1", "uniprot_id": [ { "id": "D3ZJ70_RAT", "url": "https://www.uniprot.org/uniprot/D3ZJ70", "type": "external" } ], "mass": 30075.0, "length": 276, "protein_name": "Kallikrein related-peptidase 13", "gene_name": "Klk13", "organism": "Rat", "refseq_name": "kallikrein-13 precursor", "refseq_ac": [ { "id": "NP_001163876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163876", "type": "external" } ], "gene_names_uniprotkb": "Klk13", "gene_names_refseq": "Klk13; Klnl", "protein_names_uniprotkb": "Kallikrein related-peptidase 13", "protein_names_refseq": "kallikrein l; kallikrein-13 precursor; kallikrein-13", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); ovarian carcinoma (Disease Ontology:DOID:4001)", "pathway": " (rno:292848); (R-RNO-381426); (R-RNO-6809371)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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"ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZLE3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZLI2-1", "uniprot_id": [ { "id": "D3ZLI2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZLI2", "type": "external" } ], "mass": 21596.0, "length": 182, "protein_name": "IQ motif containing F1", "gene_name": "Iqcf1", "organism": "Rat", "refseq_name": "IQ domain-containing protein F1", "refseq_ac": [ { "id": "NP_001102831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102831", "type": "external" } ], "gene_names_uniprotkb": "Iqcf1", "gene_names_refseq": "Iqcf1; RGD1565640", "protein_names_uniprotkb": "IQ motif containing F1", "protein_names_refseq": "IQ domain-containing protein F1", "tax_id": 10116, "disease": "", "pathway": " (rno:503227)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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"0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZLT1-1", "uniprot_id": [ { "id": "D3ZLT1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZLT1", "type": "external" } ], "mass": 16568.0, "length": 137, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7", "gene_name": "Ndufb7", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7", "refseq_ac": [ { "id": "NP_001101912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101912", "type": "external" } ], "gene_names_uniprotkb": "Ndufb7", "gene_names_refseq": "Ndufb7", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Complex I-B18; NADH-ubiquinone oxidoreductase B18 subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7", "tax_id": 10116, "disease": "nuclear type 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Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZLT1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZLY5-1", "uniprot_id": [ { "id": "D3ZLY5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZLY5", "type": "external" } ], "mass": 12369.0, "length": 101, "protein_name": "Cilia and flagella associated protein 141", "gene_name": "Cfap141", "organism": "Rat", "refseq_name": "cilia- and flagella-associated protein 141", "refseq_ac": [ { "id": "NP_001102656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102656", "type": "external" } ], "gene_names_uniprotkb": "Cfap141; 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Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004828 serine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070158 mitochondrial seryl-tRNA aminoacylation;GO:0006434 seryl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZM09-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZMP6-1", "uniprot_id": [ { "id": "D3ZMP6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZMP6", "type": "external" } ], "mass": 7706.0, "length": 64, "protein_name": "H/ACA ribonucleoprotein complex subunit 3", "gene_name": "Nop10", "organism": "Rat", "refseq_name": "H/ACA ribonucleoprotein complex subunit 3", "refseq_ac": [ { "id": "NP_001119572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119572", "type": "external" } ], "gene_names_uniprotkb": "Nop10; LOC100360065", "gene_names_refseq": "Nola3; Nop10", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit 3; Nucleolar protein 10; Nucleolar protein family A member 3; snoRNP protein NOP10", "protein_names_refseq": "H/ACA ribonucleoprotein complex subunit 3; NOP10 ribonucleoprotein homolog; nucleolar protein family A, member 3", "tax_id": 10116, "disease": "autosomal recessive dyskeratosis congenita 1 (Disease Ontology:DOID:0070015); dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (rno:691534); (R-RNO-171319); (R-RNO-174430)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0034513 box H/ACA snoRNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0016604 nuclear body;GO:0005697 telomerase holoenzyme complex;GO:0031429 box H/ACA snoRNP complex;GO:0090661 box H/ACA telomerase RNP complex", "go_biological_process": "GO:0031118 rRNA pseudouridine synthesis;GO:0031120 snRNA pseudouridine synthesis;GO:0007004 telomere maintenance via telomerase;GO:0000454 snoRNA guided rRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZMP6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZN46-1", "uniprot_id": [ { "id": "D3ZN46_RAT", "url": "https://www.uniprot.org/uniprot/D3ZN46", "type": "external" } ], "mass": 34902.0, "length": 303, "protein_name": "DnaJ homolog subfamily B member 6", "gene_name": "Dnajb7", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily B member 7", "refseq_ac": [ { "id": "NP_001123982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123982", "type": "external" } ], "gene_names_uniprotkb": "Dnajb7", "gene_names_refseq": "Dnajb7", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 6; Heat shock protein J2; MRJ", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 7; dnaJ homolog subfamily B member 7", "tax_id": 10116, "disease": "autosomal dominant limb-girdle muscular dystrophy type 1 (Disease Ontology:DOID:0110305)", "pathway": " (rno:685839)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0030544 Hsp70 protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZN46-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZNB1-1", "uniprot_id": [ { "id": "D3ZNB1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZNB1", "type": "external" } ], "mass": 16725.0, "length": 141, "protein_name": "Cystatin 13", "gene_name": "Cst13", "organism": "Rat", "refseq_name": "cystatin-13 precursor", "refseq_ac": [ { "id": "NP_001102813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102813", "type": "external" } ], "gene_names_uniprotkb": "Cst13", "gene_names_refseq": "Cst13; RGD1564873", "protein_names_uniprotkb": "Cystatin 13", "protein_names_refseq": "cystatin-13 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:502679)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "", "go_biological_process": "GO:0048678 response to axon injury;GO:0007431 salivary gland development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZNB1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZNE6-1", "uniprot_id": [ { "id": "D3ZNE6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZNE6", "type": "external" } ], "mass": 34880.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or4f58", "organism": "Rat", "refseq_name": "olfactory receptor Olr784", "refseq_ac": [ { "id": "NP_001000604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000604", "type": "external" } ], "gene_names_uniprotkb": "Or4f58", "gene_names_refseq": "Olr784; Or4f58", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 4F6-like; olfactory receptor 784; olfactory receptor Olr784; olfactory receptor gene Olr784", "tax_id": 10116, "disease": "", "pathway": " (rno:404793)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZAT6", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZNE6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZNQ3-1", "uniprot_id": [ { "id": "GL6D1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZNQ3", "type": "external" } ], "mass": 36613.0, "length": 311, "protein_name": "Glycosyltransferase 6 domain-containing protein 1", "gene_name": "Glt6d1", "organism": "Rat", "refseq_name": "glycosyltransferase 6 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001100029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100029", "type": "external" } ], "gene_names_uniprotkb": "Glt6d1", "gene_names_refseq": "GT6m7; Glt6d1; Gltdc1", "protein_names_uniprotkb": "Glycosyltransferase 6 domain-containing protein 1; 2.4.1.-", "protein_names_refseq": "galactosyltransferase family 6 domain containing 1; glycosyltransferase 6 domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:296577)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0031982 vesicle", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZNQ3-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZNT6-1", "uniprot_id": [ { "id": "MAFA_RAT", "url": "https://www.uniprot.org/uniprot/D3ZNT6", "type": "external" } ], "mass": 37780.0, "length": 361, "protein_name": "Transcription factor MafA", "gene_name": "Mafa", "organism": "Rat", "refseq_name": "transcription factor MafA", "refseq_ac": [ { "id": "NP_001386702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386702", "type": "external" } ], "gene_names_uniprotkb": "Mafa", "gene_names_refseq": "Mafa; RGD1562627", "protein_names_uniprotkb": "Transcription factor MafA; Pancreatic beta-cell-specific transcriptional activator", "protein_names_refseq": "pancreatic beta-cell-specific transcriptional activator; transcription factor MafA; v-maf avian musculoaponeurotic fibrosarcoma oncogene A; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A; v-maf musculoaponeurotic fibrosarcoma oncogene homolog A", "tax_id": 10116, "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:366949)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15665000;18042454;22466807;34871948", "class_list": "", "function": "L-Methionine prevents beta-cell damage by modulating the expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats., [RefSeq, PubMed]; PPAR-gamma may regulate the expression of MafA, [RefSeq, PubMed]; Transcription factor that activates insulin gene expression (PubMed:15665000). Acts synergistically with NEUROD1/BETA2 and PDX1 (By similarity). Binds the insulin enhancer C1/RIPE3b element (PubMed:15665000). Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZNT6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPA1-1", "uniprot_id": [ { "id": "D3ZPA1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPA1", "type": "external" } ], "mass": 87749.0, "length": 778, "protein_name": "GRIP and coiled-coil domain-containing protein 1", "gene_name": "Gcc1", "organism": "Rat", "refseq_name": "GRIP and coiled-coil domain-containing protein 1", "refseq_ac": [ { "id": "NP_001414052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414052", "type": "external" } ], "gene_names_uniprotkb": "Gcc1", "gene_names_refseq": "Gcc1", "protein_names_uniprotkb": "GRIP and coiled-coil domain-containing protein 1; Golgi coiled-coil protein 1", "protein_names_refseq": "GRIP and coiled-coil domain-containing protein 1; rCG28300-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100361513); (R-RNO-6811440)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Probably involved in maintaining Golgi structure., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZPA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPM4-1", "uniprot_id": [ { "id": "D3ZPM4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPM4", "type": "external" } ], "mass": 32934.0, "length": 289, "protein_name": "Coiled-coil domain containing 190", "gene_name": "Ccdc190", "organism": "Rat", "refseq_name": "coiled-coil domain-containing protein 190 isoform 2", "refseq_ac": [ { "id": "NP_001416793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416793", "type": "external" } ], "gene_names_uniprotkb": "Ccdc190; RGD1560672", "gene_names_refseq": "Ccdc190; RGD1560672", "protein_names_uniprotkb": "Coiled-coil domain containing 190", "protein_names_refseq": "coiled-coil domain-containing protein 190 isoform 2; coiled-coil domain-containing protein 190; coiled-coil domain-containing protein C1orf110 homolog", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZPM4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZPS2-1", "uniprot_id": [ { "id": "D3ZPS2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZPS2", "type": "external" } ], "mass": 34854.0, "length": 314, "protein_name": "Olfactory receptor", "gene_name": "Or5b12b", "organism": "Rat", "refseq_name": "olfactory receptor Olr340", "refseq_ac": [ { "id": "NP_001000253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000253", "type": "external" } ], "gene_names_uniprotkb": "Or5b12b", "gene_names_refseq": "Olr340; Or5b12b", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 340; olfactory receptor Olr340; olfactory receptor gene Olr340", "tax_id": 10116, "disease": "", "pathway": " (rno:293785)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZPS2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQ25-1", "uniprot_id": [ { "id": "D3ZQ25_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQ25", "type": "external" } ], "mass": 78072.0, "length": 705, "protein_name": "Fibulin-1", "gene_name": "Fbln1", "organism": "Rat", "refseq_name": "fibulin-1 precursor", "refseq_ac": [ { "id": "NP_001121019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121019", "type": "external" } ], "gene_names_uniprotkb": "Fbln1", "gene_names_refseq": "Fbln1", "protein_names_uniprotkb": "Fibulin-1", "protein_names_refseq": "Fbln1 protein-like; fibulin-1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:315191)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32640908", "class_list": "", "function": "Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus., [RefSeq, PubMed]; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0016504 peptidase activator activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0071953 elastic fiber;GO:0005576 extracellular region", "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate;GO:2000647 negative regulation of stem cell proliferation;GO:0007162 negative regulation of cell adhesion;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZQ25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQ42-1", "uniprot_id": [ { "id": "D3ZQ42_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQ42", "type": "external" } ], "mass": 34711.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or2y15", "organism": "Rat", "refseq_name": "olfactory receptor Olr1393", "refseq_ac": [ { "id": "NP_001000524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000524", "type": "external" } ], "gene_names_uniprotkb": "Or2y15", "gene_names_refseq": "Olr1393; Or2y15; ratchr10-34852920-34853855_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1393; olfactory receptor Olr1393; olfactory receptor gene Olr1393", "tax_id": 10116, "disease": "", "pathway": " (rno:363585)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQ42-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQ50-1", "uniprot_id": [ { "id": "D3ZQ50_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQ50", "type": "external" } ], "mass": 34751.0, "length": 308, "protein_name": "Olfactory receptor", "gene_name": "Or1q1", "organism": "Rat", "refseq_name": "olfactory receptor Olr420", "refseq_ac": [ { "id": "NP_001000389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000389", "type": "external" } ], "gene_names_uniprotkb": "Or1q1; Olr420", "gene_names_refseq": "Olr420; Or1q1; ratchr3-16368867-16369793_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 420; olfactory receptor Olr420; olfactory receptor gene Olr420", "tax_id": 10116, "disease": "", "pathway": " (rno:296682)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQ50-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQB7-1", "uniprot_id": [ { "id": "D3ZQB7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQB7", "type": "external" } ], "mass": 115090.0, "length": 1010, "protein_name": "PHD finger protein 20", "gene_name": "Phf20", "organism": "Rat", "refseq_name": "PHD finger protein 20", "refseq_ac": [ { "id": "NP_001101265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101265", "type": "external" } ], "gene_names_uniprotkb": "Phf20", "gene_names_refseq": "Phf20; RGD1305020", "protein_names_uniprotkb": "PHD finger protein 20", "protein_names_refseq": "PHD finger protein 20", "tax_id": 10116, "disease": "", "pathway": " (rno:311575); (R-RNO-3214847); (R-RNO-6804757); (R-RNO-6804759); (R-RNO-69541); (R-RNO-9772755)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0071339 MLL1 complex;GO:0000123 histone acetyltransferase complex;GO:0044545 NSL complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQB7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQC1-1", "uniprot_id": [ { "id": "D3ZQC1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQC1", "type": "external" } ], "mass": 37148.0, "length": 325, "protein_name": "Hexosyltransferase", "gene_name": "B3galt6", "organism": "Rat", "refseq_name": "beta-1,3-galactosyltransferase 6", "refseq_ac": [ { "id": "NP_001100169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100169", "type": "external" } ], "gene_names_uniprotkb": "B3galt6", "gene_names_refseq": "B3galt6", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "UDP-Gal:betaGal beta 1,3-galactosyltransferase 6; UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6; beta-1,3-galactosyltransferase 6", "tax_id": 10116, "disease": "Ehlers-Danlos syndrome spondylodysplastic type 2 (Disease Ontology:DOID:0050802); spondyloepimetaphyseal dysplasia with joint laxity type 1 (Disease Ontology:DOID:0112198); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359)", "pathway": " (rno:298690); (R-RNO-1971475)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0035250 UDP-galactosyltransferase activity;GO:0047220 galactosylxylosylprotein 3-beta-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005797 Golgi medial cisterna", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0050651 dermatan sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQC1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQF9-1", "uniprot_id": [ { "id": "LX12E_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQF9", "type": "external" } ], "mass": 75466.0, "length": 662, "protein_name": "Polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type", "gene_name": "Alox12e", "organism": "Rat", "refseq_name": "polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type", "refseq_ac": [ { "id": "NP_001100484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100484", "type": "external" } ], "gene_names_uniprotkb": "Alox12e", "gene_names_refseq": "12-LOX-e; 12-LOX; Alox12e", "protein_names_uniprotkb": "Polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type; 1.13.11.-; 1.13.11.31; 12-LOX-e; Arachidonate (12S)-lipoxygenase, epidermal-type; Linoleate (13S)-lipoxygenase; e(12S)-LOX", "protein_names_refseq": "arachidonate (12S)-lipoxygenase, epidermal-type; arachidonate 12-lipoxygenase, epidermal-type; arachidonate lipoxygenase, epidermal; e(12S)-LOX; linoleate (13S)-lipoxygenase; polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type", "tax_id": 10116, "disease": "", "pathway": " (rno:303252)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23382512;29393594", "class_list": "", "function": "Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:23382512). Shows increasing catalytic activity within the series arachidonic acid < 5,8,11-eicosatrienoic acid < linoleic acid < 8,11,14-eicosatrienoic acid (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.31", "type": "external" }, { "id": "1.13.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.33", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0016165 linoleate 13S-lipoxygenase activity;GO:0050473 arachidonate 15-lipoxygenase activity;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0034440 lipid oxidation;GO:0019372 lipoxygenase pathway;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZQF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQL6-1", "uniprot_id": [ { "id": "MILK1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQL6", "type": "external" } ], "mass": 92644.0, "length": 855, "protein_name": "MICAL-like protein 1", "gene_name": "Micall1", "organism": "Rat", "refseq_name": "MICAL-like protein 1", "refseq_ac": [ { "id": "NP_001406561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406561", "type": "external" } ], "gene_names_uniprotkb": "Micall1", "gene_names_refseq": "Micall1; RGD1305415", "protein_names_uniprotkb": "MICAL-like protein 1", "protein_names_refseq": "MICAL-like protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362958)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;23572513", "class_list": "", "function": "Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane. Also involved in cargo protein delivery to the plasma membrane. Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (By similarity). May indirectly play a role in neurite outgrowth (PubMed:23572513)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0008093 cytoskeletal anchor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005929 cilium;GO:0030054 cell junction", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0031175 neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus;GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZQL6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZQQ9-1", "uniprot_id": [ { "id": "D3ZQQ9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZQQ9", "type": "external" } ], "mass": 21228.0, "length": 178, "protein_name": "RNA polymerase I subunit H, antisense", "gene_name": "Polr1has", "organism": "Rat", "refseq_name": "uncharacterized protein LOC685722", "refseq_ac": [ { "id": "NP_001102949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102949", "type": "external" } ], "gene_names_uniprotkb": "Polr1has; LOC685722; Znrd1-as1; Znrd1as", "gene_names_refseq": "Polr1has; Znrd1-as1; Znrd1asp; Znrd1as", "protein_names_uniprotkb": "RNA polymerase I subunit H, antisense", "protein_names_refseq": "ZNRD1 antisense RNA 1; uncharacterized protein LOC685722; zinc ribbon domain containing 1 antisense", "tax_id": 10116, "disease": "", "pathway": " (rno:685722)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZQQ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZR08-1", "uniprot_id": [ { "id": "D3ZR08_RAT", "url": "https://www.uniprot.org/uniprot/D3ZR08", "type": "external" } ], "mass": 48362.0, "length": 432, "protein_name": "DNA damage-binding protein 2", "gene_name": "Ddb2", "organism": "Rat", "refseq_name": "DNA damage-binding protein 2", "refseq_ac": [ { "id": "NP_001258275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258275", "type": "external" } ], "gene_names_uniprotkb": "Ddb2", "gene_names_refseq": "Ddb2", "protein_names_uniprotkb": "DNA damage-binding protein 2; Damage-specific DNA-binding protein 2", "protein_names_refseq": "DNA damage-binding protein 2", "tax_id": 10116, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); xeroderma pigmentosum group E (Disease Ontology:DOID:0110846)", "pathway": " (rno:100362121); (R-RNO-5689880); (R-RNO-5696394); (R-RNO-5696395); (R-RNO-5696400); (R-RNO-8951664)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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[provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZSJ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZSX8-1", "uniprot_id": [ { "id": "D3ZSX8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZSX8", "type": "external" } ], "mass": 88177.0, "length": 779, "protein_name": "Cysteine-rich protein 2-binding protein", "gene_name": "Kat14", "organism": "Rat", "refseq_name": "cysteine-rich protein 2-binding protein", "refseq_ac": [ { "id": "NP_001178784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178784", "type": "external" } ], "gene_names_uniprotkb": "Kat14; Csrp2bp", "gene_names_refseq": "Csrp2bp; Kat14", "protein_names_uniprotkb": "Cysteine-rich protein 2-binding protein; ADA2A-containing complex subunit 2; CRP2-binding partner; Lysine acetyltransferase 14", "protein_names_refseq": "CSRP2 binding protein; cysteine and glycine-rich protein 2 binding protein; cysteine-rich protein 2-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:362224); (R-RNO-9772755)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004402 histone acetyltransferase activity;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0140672 ATAC complex", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZSX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZSY6-1", "uniprot_id": [ { "id": "D3ZSY6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZSY6", "type": "external" } ], "mass": 21263.0, "length": 185, "protein_name": "DNA replication complex GINS protein PSF2", "gene_name": "Gins2", "organism": "Rat", "refseq_name": "DNA replication complex GINS protein PSF2", "refseq_ac": [ { "id": "NP_001099660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099660", "type": "external" } ], "gene_names_uniprotkb": "Gins2", "gene_names_refseq": "Gins2; RGD1311055", "protein_names_uniprotkb": "DNA replication complex GINS protein PSF2", "protein_names_refseq": "DNA replication complex GINS protein PSF2; GINS complex subunit 2 (Psf2 homolog)", "tax_id": 10116, "disease": "", "pathway": " (rno:292058); (R-RNO-176974)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZSY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZSY8-1", "uniprot_id": [ { "id": "D3ZSY8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZSY8", "type": "external" } ], "mass": 86649.0, "length": 795, "protein_name": "TBC1 domain family, member 10b", "gene_name": "Tbc1d10b", "organism": "Rat", "refseq_name": "TBC1 domain family member 10B", "refseq_ac": [ { "id": "NP_001102391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102391", "type": "external" } ], "gene_names_uniprotkb": "Tbc1d10b", "gene_names_refseq": "RGD1309191; Tbc1d10b", "protein_names_uniprotkb": "TBC1 domain family, member 10b", "protein_names_refseq": "TBC1 domain family member 10B", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); Ewing sarcoma (Disease Ontology:DOID:3369)", "pathway": " (rno:365372); (R-RNO-8854214)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "19077034;22673903;38843836", "class_list": "", "function": "FLJ13130 is a novel type of Rab-GAP that exhibits broad GAP specificity and inactivates several distinct Rab isoforms, including Rab3A, just near the plasma membrane., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3ZSY8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTJ8-1", "uniprot_id": [ { "id": "D3ZTJ8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTJ8", "type": "external" } ], "mass": 13849.0, "length": 122, "protein_name": "Similar to human chromosome 11 open reading frame 86", "gene_name": "C1h11orf86", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "C1h11orf86; LOC689065", "gene_names_refseq": "", "protein_names_uniprotkb": "Similar to human chromosome 11 open reading frame 86", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:689065)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTJ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTW8-1", "uniprot_id": [ { "id": "D3ZTW8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTW8", "type": "external" } ], "mass": 15545.0, "length": 145, "protein_name": "Large ribosomal subunit protein bL27m", "gene_name": "Mrpl27", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mrpl27", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein bL27m; 39S ribosomal protein L27, mitochondrial", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:287635); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZTW8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUA0-1", "uniprot_id": [ { "id": "MTD2L_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUA0", "type": "external" } ], "mass": 36426.0, "length": 338, "protein_name": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial", "gene_name": "Mthfd2l", "organism": "Rat", "refseq_name": "bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial", "refseq_ac": [ { "id": "NP_001100681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100681", "type": "external" } ], "gene_names_uniprotkb": "Mthfd2l", "gene_names_refseq": "Mthfd2l; RGD1310879", "protein_names_uniprotkb": "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial; MTHFD2-like; NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein", "protein_names_refseq": "MTHFD2-like; NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein; bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial; methylenetetrahydrofolate dehydrogenase 2-like; probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:305248); (R-RNO-196757)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21163947;24733394", "class_list": "", "function": "A new mitochondrial CH(2)-THF dehydrogenase isozyme, encoded by the MTHFD2L gene, has now been identified. The recombinant protein exhibits robust NADP(+)-dependent CH(2)-THF dehydrogenase activity when expressed in yeast., [RefSeq, PubMed]; Bifunctional mitochondrial folate-interconverting enzyme that has both NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities., [UniProtKB, PubMed, PubMed]; Has no NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase activity., [UniProtKB, PubMed]; We show here that the MTHFD2L enzyme is bifunctional, possessing both CH2-THF dehydrogenase and 5,10-methenyl-THF cyclohydrolase activities., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.9", "type": "external" }, { "id": "6.3.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.3", "type": "external" }, { "id": "1.5.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.5", "type": "external" }, { "id": "1.5.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.15", "type": "external" } ], "go_molecular_function": "GO:0004477 methenyltetrahydrofolate cyclohydrolase activity;GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity;GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0035999 tetrahydrofolate interconversion;GO:0006164 purine nucleotide biosynthetic process;GO:0009086 methionine biosynthetic process;GO:0009256 10-formyltetrahydrofolate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZUA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUB4-1", "uniprot_id": [ { "id": "D3ZUB4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUB4", "type": "external" } ], "mass": 10566.0, "length": 99, "protein_name": "Transmembrane protein 14A", "gene_name": "Tmem14a", "organism": "Rat", "refseq_name": "transmembrane protein 14A", "refseq_ac": [ { "id": "NP_001102260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102260", "type": "external" } ], "gene_names_uniprotkb": "Tmem14a", "gene_names_refseq": "Tmem14a", "protein_names_uniprotkb": "Transmembrane protein 14A", "protein_names_refseq": "transmembrane protein 14A", "tax_id": 10116, "disease": "", "pathway": " (rno:363206)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38054547", "class_list": "", "function": "Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway., [UniProtKB, UniProtKB]; Transmembrane protein 14A protects glomerular filtration barrier integrity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZUB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUI0-1", "uniprot_id": [ { "id": "D3ZUI0_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUI0", "type": "external" } ], "mass": 62890.0, "length": 572, "protein_name": "Golgi associated RAB2 interactor family member 4", "gene_name": "Garin4", "organism": "Rat", "refseq_name": "Golgi-associated RAB2 interactor protein 4", "refseq_ac": [ { "id": "NP_001102554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102554", "type": "external" } ], "gene_names_uniprotkb": "Garin4; Fam71a", "gene_names_refseq": "Fam71a; Garin4; RGD1561646", "protein_names_uniprotkb": "Golgi associated RAB2 interactor family member 4", "protein_names_refseq": "Golgi-associated RAB2 interactor protein 4; family with sequence similarity 71, member A", "tax_id": 10116, "disease": "", "pathway": " (rno:498311)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0061827 sperm head;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0007286 spermatid development;GO:0007341 penetration of zona pellucida;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZUI0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUJ9-1", "uniprot_id": [ { "id": "D3ZUJ9_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUJ9", "type": "external" } ], "mass": 52658.0, "length": 463, "protein_name": "Sorting nexin-8", "gene_name": "Snx8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Snx8", "gene_names_refseq": "", "protein_names_uniprotkb": "Sorting nexin-8", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:288504)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0030904 retromer complex;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0034498 early endosome to Golgi transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZUJ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUL5-1", "uniprot_id": [ { "id": "D3ZUL5_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUL5", "type": "external" } ], "mass": 20984.0, "length": 188, "protein_name": "Myc target 1", "gene_name": "Myct1", "organism": "Rat", "refseq_name": "myc target protein 1", "refseq_ac": [ { "id": "NP_001099677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099677", "type": "external" } ], "gene_names_uniprotkb": "Myct1", "gene_names_refseq": "Myct1", "protein_names_uniprotkb": "Myc target 1", "protein_names_refseq": "myc target protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:292264)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16365299;22673903", "class_list": "", "function": "The properties imparted by MT-MC1 are the result of its control of a small and select c-Myc target gene population, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZUL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUU2-1", "uniprot_id": [ { "id": "GZF1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUU2", "type": "external" } ], "mass": 79887.0, "length": 707, "protein_name": "GDNF-inducible zinc finger protein 1", "gene_name": "Gzf1", "organism": "Rat", "refseq_name": "GDNF-inducible zinc finger protein 1", "refseq_ac": [ { "id": "NP_001101258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101258", "type": "external" } ], "gene_names_uniprotkb": "Gzf1; Zfp336", "gene_names_refseq": "Gzf1; RGD1562321; Zfp336", "protein_names_uniprotkb": "GDNF-inducible zinc finger protein 1; Zinc finger protein 336", "protein_names_refseq": "GDNF-inducible zinc finger protein 1; zinc finger protein 336", "tax_id": 10116, "disease": "", "pathway": " (rno:311508)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0001658 branching involved in ureteric bud morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZUU2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUW6-1", "uniprot_id": [ { "id": "D3ZUW6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUW6", "type": "external" } ], "mass": 19679.0, "length": 179, "protein_name": "Ubiquitin-conjugating enzyme E2 C", "gene_name": "Ube2c", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 C", "refseq_ac": [ { "id": "NP_001100012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100012", "type": "external" } ], "gene_names_uniprotkb": "Ube2c", "gene_names_refseq": "Ube2c", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 C; (E3-independent) E2 ubiquitin-conjugating enzyme C; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme C; Ubiquitin carrier protein C; Ubiquitin-protein ligase C", "protein_names_refseq": "ubiquitin-conjugating enzyme E2 C", "tax_id": 10116, "disease": "", "pathway": " (rno:296368); (R-RNO-141430); (R-RNO-174048); (R-RNO-174084); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-176407); (R-RNO-176408); (R-RNO-176412); (R-RNO-179409); (R-RNO-2467813); (R-RNO-2559582); (R-RNO-68867); (R-RNO-69017); (R-RNO-8866652); (R-RNO-983168)", "pathway_count": 17, "publication_count": 2, "publication_id_list": "17167411;21448667", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit., [UniProtKB, UniProtKB, UniProtKB]; Data show that changes in Ube2c (UbcH10) levels correlate with VSMC proliferation and neointimal hyperplasia, making UbcH10 a promising therapeutic target for inhibiting this proliferative disease., [RefSeq, PubMed]; Oxidative stress upregulated ubiquitin proteasome pathway(UPP) and increased turnover of ubiquitin conjugates. Upregulation of UPP may account for cell response to stress in conditions where oxidative stress is overexpressed. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0044389 ubiquitin-like protein ligase binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005680 anaphase-promoting complex;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZUW6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUX1-1", "uniprot_id": [ { "id": "D3ZUX1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUX1", "type": "external" } ], "mass": 42476.0, "length": 376, "protein_name": "Hydroxylysine kinase", "gene_name": "Hykk", "organism": "Rat", "refseq_name": "hydroxylysine kinase", "refseq_ac": [ { "id": "NP_001100293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100293", "type": "external" } ], "gene_names_uniprotkb": "Hykk; Agphd1", "gene_names_refseq": "Agphd1; Hykk; RGD1308677", "protein_names_uniprotkb": "Hydroxylysine kinase; 2.7.1.81; Aminoglycoside phosphotransferase domain-containing protein 1", "protein_names_refseq": "aminoglycoside phosphotransferase domain containing 1; aminoglycoside phosphotransferase domain-containing protein 1; hydroxylysine kinase", "tax_id": 10116, "disease": "chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:300723); (R-RNO-71064)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.81", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.81", "type": "external" } ], "go_molecular_function": "GO:0047992 hydroxylysine kinase activity;GO:0019202 amino acid kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZUX1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVA3-1", "uniprot_id": [ { "id": "D3ZVA3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVA3", "type": "external" } ], "mass": 36873.0, "length": 327, "protein_name": "Olfactory receptor family 52 subfamily S member 1", "gene_name": "Or52s1", "organism": "Rat", "refseq_name": "olfactory receptor Olr84", "refseq_ac": [ { "id": "NP_001000137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000137", "type": "external" } ], "gene_names_uniprotkb": "Or52s1", "gene_names_refseq": "Olr84; Or52s1", "protein_names_uniprotkb": "Olfactory receptor family 52 subfamily S member 1", "protein_names_refseq": "olfactory receptor 84; olfactory receptor Olr84; olfactory receptor gene Olr84", "tax_id": 10116, "disease": "", "pathway": " (rno:293227)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]; Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVA3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVS6-1", "uniprot_id": [ { "id": "D3ZVS6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVS6", "type": "external" } ], "mass": 71330.0, "length": 623, "protein_name": "Kelch repeat and BTB domain containing 2", "gene_name": "Kbtbd2", "organism": "Rat", "refseq_name": "kelch repeat and BTB domain-containing protein 2", "refseq_ac": [ { "id": "NP_001101331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101331", "type": "external" } ], "gene_names_uniprotkb": "Kbtbd2", "gene_names_refseq": "Kbtbd2", "protein_names_uniprotkb": "Kelch repeat and BTB domain containing 2", "protein_names_refseq": "kelch repeat and BTB (POZ) domain containing 2; kelch repeat and BTB domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:312372)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:1900076 regulation of cellular response to insulin stimulus;GO:0006629 lipid metabolic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006006 glucose metabolic process;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVS6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVT3-1", "uniprot_id": [ { "id": "D3ZVT3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVT3", "type": "external" } ], "mass": 124947.0, "length": 1126, "protein_name": "Caspase recruitment domain family, member 6", "gene_name": "Card6", "organism": "Rat", "refseq_name": "caspase recruitment domain-containing protein 6", "refseq_ac": [ { "id": "NP_001381996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381996", "type": "external" } ], "gene_names_uniprotkb": "Card6", "gene_names_refseq": "Card6", "protein_names_uniprotkb": "Caspase recruitment domain family, member 6", "protein_names_refseq": "caspase recruitment domain-containing protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:294770)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0033344 cholesterol efflux;GO:0042981 regulation of apoptotic process;GO:0070508 cholesterol import;GO:0010467 gene expression;GO:0042116 macrophage activation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVT3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVT4-1", "uniprot_id": [ { "id": "D3ZVT4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVT4", "type": "external" } ], "mass": 22565.0, "length": 207, "protein_name": "Vexin", "gene_name": "Vxn", "organism": "Rat", "refseq_name": "vexin", "refseq_ac": [ { "id": "NP_001102730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102730", "type": "external" } ], "gene_names_uniprotkb": "Vxn; RGD1561849", "gene_names_refseq": "RGD1561849; Vxn", "protein_names_uniprotkb": "Vexin", "protein_names_refseq": "uncharacterized protein C8orf46 homolog; vexin", "tax_id": 10116, "disease": "", "pathway": " (rno:500393)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane", "go_biological_process": "GO:0030182 neuron differentiation;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZVT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZW55-1", "uniprot_id": [ { "id": "ITPA_RAT", "url": "https://www.uniprot.org/uniprot/D3ZW55", "type": "external" } ], "mass": 21927.0, "length": 198, "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "Itpa", "organism": "Rat", "refseq_name": "inosine triphosphate pyrophosphatase", "refseq_ac": [ { "id": "NP_001101244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101244", "type": "external" } ], "gene_names_uniprotkb": "Itpa; ITPA", "gene_names_refseq": "Itpa", "protein_names_uniprotkb": "Inosine triphosphate pyrophosphatase; 3.6.1.66; ITPase; Inosine triphosphatase; NTPase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; XTP/dITP diphosphatase", "protein_names_refseq": "ITPase; NTPase; XTP/dITP diphosphatase; inosine triphosphatase (nucleoside triphosphate pyrophosphatase); inosine triphosphate pyrophosphatase; non-canonical purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase; nucleoside-triphosphate diphosphatase; nucleoside-triphosphate pyrophosphatase", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 35 (Disease Ontology:DOID:0080458); thrombocytopenia (Disease Ontology:DOID:1588); hepatitis C (Disease Ontology:DOID:1883); anemia (Disease Ontology:DOID:2355); hemolytic anemia (Disease Ontology:DOID:583); rheumatoid arthritis (Disease Ontology:DOID:7148); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:311422); (R-RNO-74259); (R-RNO-9755088)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions., [UniProtKB, HAMAP, UniProtKB]; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.66", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0047429 nucleoside triphosphate diphosphatase activity;GO:0035870 dITP diphosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009143 nucleoside triphosphate catabolic process;GO:0051276 chromosome organization;GO:0006193 ITP catabolic process;GO:0009204 deoxyribonucleoside triphosphate catabolic process;GO:0009117 nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZW55-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZW59-1", "uniprot_id": [ { "id": "D3ZW59_RAT", "url": "https://www.uniprot.org/uniprot/D3ZW59", "type": "external" } ], "mass": 38620.0, "length": 349, "protein_name": "Integrin beta-1-binding protein 2", "gene_name": "Itgb1bp2", "organism": "Rat", "refseq_name": "integrin beta-1-binding protein 2", "refseq_ac": [ { "id": "NP_001101715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101715", "type": "external" } ], "gene_names_uniprotkb": "Itgb1bp2", "gene_names_refseq": "Itgb1bp2; RGD1565015", "protein_names_uniprotkb": "Integrin beta-1-binding protein 2; Melusin", "protein_names_refseq": "integrin beta-1-binding protein 2; melusin", "tax_id": 10116, "disease": "", "pathway": " (rno:317258)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21757757;23198998;30904475", "class_list": "", "function": "METH can produce cardiac damage and apoptosis by decreasing melusin., [RefSeq, PubMed]; May play a role during maturation and/or organization of muscles cells., [UniProtKB, UniProtKB]; Multiple hypertrophic stimuli regulate melusin expression predominately in the atria, which may represent a necessary initial step in early adaptive remodelling processes in left ventricular hypertrophy., [RefSeq, PubMed]; PI3K regulates the expression of genes essential for cardiac structure and Z-disc signaling, interacts with melusin, and is critical for Z-disc alignment, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008270 zinc ion binding;GO:0017124 SH3 domain binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0030018 Z disc", "go_biological_process": "GO:0051298 centrosome duplication", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZW59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZWD6-1", "uniprot_id": [ { "id": "D3ZWD6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZWD6", "type": "external" } ], "mass": 66273.0, "length": 587, "protein_name": "Complement C8 alpha chain", "gene_name": "C8a", "organism": "Rat", "refseq_name": "complement component C8 alpha chain precursor", "refseq_ac": [ { "id": "NP_001100140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100140", "type": "external" } ], "gene_names_uniprotkb": "C8a", "gene_names_refseq": "C8a", "protein_names_uniprotkb": "Complement C8 alpha chain", "protein_names_refseq": "complement component 8 alpha subunit; complement component 8, alpha polypeptide; complement component C8 alpha chain precursor; complement component C8 alpha chain", "tax_id": 10116, "disease": "type I complement component 8 deficiency (Disease Ontology:DOID:0060301); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:298288)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18178252", "class_list": "", "function": "The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0022829 wide pore channel activity;GO:0001848 complement binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane", "go_biological_process": "GO:0031640 killing of cells of another organism;GO:0006958 complement activation, classical pathway;GO:0006956 complement activation;GO:0160257 complement activation, GZMK pathway;GO:0006957 complement activation, alternative pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZWD6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZWZ6-1", "uniprot_id": [ { "id": "D3ZWZ6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZWZ6", "type": "external" } ], "mass": 65405.0, "length": 592, "protein_name": "Insulin-like growth factor 2 mRNA-binding protein 2", "gene_name": "Igf2bp2", "organism": "Rat", "refseq_name": "insulin-like growth factor 2 mRNA-binding protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001257527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257527", "type": "external" } ], "gene_names_uniprotkb": "Igf2bp2", "gene_names_refseq": "Igf2bp2; RGD1305614", "protein_names_uniprotkb": "Insulin-like growth factor 2 mRNA-binding protein 2; IGF-II mRNA-binding protein 2; VICKZ family member 2", "protein_names_refseq": "insulin-like growth factor 2 mRNA-binding protein 2 isoform 1", "tax_id": 10116, "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:303824)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22513850;37981258", "class_list": "", "function": "Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to promote osteogenic differentiation of bone marrow mesenchymal stem cells., [RefSeq, PubMed]; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD., [UniProtKB, UniProtKB]; The protein encoded by this gene is a member of a family of mRNA binding proteins that have been shown to bind to several different mRNAs in mammalian cells, including insulin-like growth factor 2 mRNA. Generation of two different isoforms by alternative translation initiation at an internal start codon, has been described for this gene (PMID:22427968). [provided by RefSeq, Jul 2012]., [RefSeq]; Together, these studies provide evidence for regulation of Lamb2 translation by IMP2, an RNA binding protein that targets Lamb2 mRNA to the actin cytoskeleton., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity;GO:0048027 mRNA 5'-UTR binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0000932 P-body", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:0007399 nervous system development;GO:0097009 energy homeostasis;GO:0017148 negative regulation of translation;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZWZ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZWZ9-1", "uniprot_id": [ { "id": "GP107_RAT", "url": "https://www.uniprot.org/uniprot/D3ZWZ9", "type": "external" } ], "mass": 62002.0, "length": 551, "protein_name": "Protein GPR107", "gene_name": "Gpr107", "organism": "Rat", "refseq_name": "protein GPR107 precursor", "refseq_ac": [ { "id": "NP_001101298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101298", "type": "external" } ], "gene_names_uniprotkb": "Gpr107", "gene_names_refseq": "Gpr107", "protein_names_uniprotkb": "Protein GPR107", "protein_names_refseq": "protein GPR107 precursor; protein GPR107", "tax_id": 10116, "disease": "", "pathway": " (rno:311857)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;22933024;26561648", "class_list": "", "function": "GPR107 is a promising candidate receptor for neuronostatin, and neuronostatin, interacting with GPR107, may play an important role in the central control of cardiovascular function., [RefSeq, PubMed]; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024, PubMed:26561648). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (PubMed:26561648)., [UniProtKB, PubMed, PubMed]; Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha-cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032050 clathrin heavy chain binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZWZ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZX04-1", "uniprot_id": [ { "id": "D3ZX04_RAT", "url": "https://www.uniprot.org/uniprot/D3ZX04", "type": "external" } ], "mass": 163378.0, "length": 1495, "protein_name": "ATP-binding cassette sub-family C member 10", "gene_name": "Abcc10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Abcc10", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 10; 7.6.2.2; 7.6.2.3; Multidrug resistance-associated protein 7", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-382556)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity;GO:0140359 ABC-type transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0055085 transmembrane transport;GO:0015711 organic anion transport;GO:0006691 leukotriene metabolic process;GO:0071716 leukotriene transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZX04-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXC8-1", "uniprot_id": [ { "id": "D3ZXC8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXC8", "type": "external" } ], "mass": 23412.0, "length": 206, "protein_name": "EBP like", "gene_name": "Ebpl", "organism": "Rat", "refseq_name": "emopamil-binding protein-like", "refseq_ac": [ { "id": "NP_001101851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101851", "type": "external" } ], "gene_names_uniprotkb": "Ebpl", "gene_names_refseq": "Ebpl", "protein_names_uniprotkb": "EBP like", "protein_names_refseq": "emopamil binding protein-like; emopamil-binding protein-like", "tax_id": 10116, "disease": "", "pathway": " (rno:361054)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0047750 cholestenol delta-isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0016125 sterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZXC8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXM2-1", "uniprot_id": [ { "id": "D3ZXM2_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXM2", "type": "external" } ], "mass": 42850.0, "length": 392, "protein_name": "Cell cycle checkpoint control protein", "gene_name": "Rad9a", "organism": "Rat", "refseq_name": "cell cycle checkpoint control protein RAD9A", "refseq_ac": [ { "id": "NP_001414523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001414523", "type": "external" } ], "gene_names_uniprotkb": "Rad9a", "gene_names_refseq": "Rad9a; Rad9", "protein_names_uniprotkb": "Cell cycle checkpoint control protein", "protein_names_refseq": "RAD9 homolog A; cell cycle checkpoint control protein RAD9A; rCG47324-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100361529); (R-RNO-176187); (R-RNO-5685938); (R-RNO-5693607); (R-RNO-6804756); (R-RNO-69473)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0017124 SH3 domain binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0030896 checkpoint clamp complex", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0071479 cellular response to ionizing radiation;GO:0031573 mitotic intra-S DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZXM2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZXU4-1", "uniprot_id": [ { "id": "D3ZXU4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZXU4", "type": "external" } ], "mass": 41829.0, "length": 385, "protein_name": "Serine protease 42", "gene_name": "Prss42", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prss42", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine protease 42", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:301027)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0016485 protein processing;GO:0007281 germ cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZXU4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZY51-1", "uniprot_id": [ { "id": "D3ZY51_RAT", "url": "https://www.uniprot.org/uniprot/D3ZY51", "type": "external" } ], "mass": 80963.0, "length": 728, "protein_name": "Plakophilin-1", "gene_name": "Pkp1", "organism": "Rat", "refseq_name": "plakophilin-1", "refseq_ac": [ { "id": "NP_001381145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381145", "type": "external" } ], "gene_names_uniprotkb": "Pkp1", "gene_names_refseq": "Pkp1", "protein_names_uniprotkb": "Plakophilin-1", "protein_names_refseq": "plakophilin-1", "tax_id": 10116, "disease": "ectodermal dysplasia (Disease Ontology:DOID:2121)", "pathway": " (rno:304822); (R-RNO-351906); (R-RNO-6798695); (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0045296 cadherin binding;GO:0005521 lamin binding", "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0045110 intermediate filament bundle assembly;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZY51-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZY65-1", "uniprot_id": [ { "id": "D3ZY65_RAT", "url": "https://www.uniprot.org/uniprot/D3ZY65", "type": "external" } ], "mass": 51846.0, "length": 475, "protein_name": "Transmembrane protease serine 3", "gene_name": "Tmprss3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmprss3", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protease serine 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 8 (Disease Ontology:DOID:0110527); sensorineural hearing loss (Disease Ontology:DOID:10003); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017080 sodium channel regulator activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016485 protein processing;GO:0006883 intracellular sodium ion homeostasis;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZY65-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZY68-1", "uniprot_id": [ { "id": "GATC_RAT", "url": "https://www.uniprot.org/uniprot/D3ZY68", "type": "external" } ], "mass": 16833.0, "length": 155, "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial", "gene_name": "Gatc", "organism": "Rat", "refseq_name": "glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial", "refseq_ac": [ { "id": "NP_001101809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101809", "type": "external" } ], "gene_names_uniprotkb": "Gatc; GATC; LOC100909836", "gene_names_refseq": "Gatc; RGD1309698", "protein_names_uniprotkb": "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; 6.3.5.-; Glu-AdT subunit C", "protein_names_refseq": "gatC-like protein; glu-AdT subunit C; glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial-like; glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; glutamyl-tRNA(Gln) amidotransferase, subunit C", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 42 (Disease Ontology:DOID:0112118)", "pathway": " (rno:360821)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.-", "type": "external" }, { "id": "6.3.5.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.7", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZY68-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYC1-1", "uniprot_id": [ { "id": "D3ZYC1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYC1", "type": "external" } ], "mass": 102488.0, "length": 937, "protein_name": "Zinc finger protein 507", "gene_name": "Zfp507", "organism": "Rat", "refseq_name": "zinc finger protein 507", "refseq_ac": [ { "id": "NP_001099718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099718", "type": "external" } ], "gene_names_uniprotkb": "Zfp507", "gene_names_refseq": "Zfp507; Znf507", "protein_names_uniprotkb": "Zinc finger protein 507", "protein_names_refseq": "zinc finger protein 507", "tax_id": 10116, "disease": "", "pathway": " (rno:292816)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZYC1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYD4-1", "uniprot_id": [ { "id": "D3ZYD4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYD4", "type": "external" } ], "mass": 13588.0, "length": 141, "protein_name": "Late cornified envelope 1E", "gene_name": "Lce1e", "organism": "Rat", "refseq_name": "late cornified envelope 1E", "refseq_ac": [ { "id": "NP_001102963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102963", "type": "external" } ], "gene_names_uniprotkb": "Lce1e; Lce1l", "gene_names_refseq": "Lce1e; Lce1l", "protein_names_uniprotkb": "Late cornified envelope 1E", "protein_names_refseq": "late cornified envelope 1E; late cornified envelope 1L", "tax_id": 10116, "disease": "", "pathway": " (rno:686125)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0031424 keratinization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZYD4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYQ7-1", "uniprot_id": [ { "id": "D3ZYQ7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYQ7", "type": "external" } ], "mass": 70974.0, "length": 630, "protein_name": "Kelch-like protein 14", "gene_name": "Klhl14", "organism": "Rat", "refseq_name": "kelch-like protein 14", "refseq_ac": [ { "id": "NP_001102355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102355", "type": "external" } ], "gene_names_uniprotkb": "Klhl14", "gene_names_refseq": "Klhl14; RGD1566178", "protein_names_uniprotkb": "Kelch-like protein 14; Protein interactor of Torsin-1A", "protein_names_refseq": "kelch-like 14; kelch-like protein 14", "tax_id": 10116, "disease": "", "pathway": " (rno:364823)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2I4HY32;A6J2H6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane;GO:0043005 neuron projection", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZYQ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYS4-1", "uniprot_id": [ { "id": "D3ZYS4_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYS4", "type": "external" } ], "mass": 80920.0, "length": 748, "protein_name": "Fidgetin", "gene_name": "Fign", "organism": "Rat", "refseq_name": "fidgetin isoform X2", "refseq_ac": [ { "id": "XP_008760111", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008760111", "type": "external" } ], "gene_names_uniprotkb": "Fign", "gene_names_refseq": "Fign", "protein_names_uniprotkb": "Fidgetin", "protein_names_refseq": "fidgetin isoform X2", "tax_id": 10116, "disease": "", "pathway": " (rno:295649)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I5ZRP0", "ec_number_list": [], "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016363 nuclear matrix", "go_biological_process": "GO:0051013 microtubule severing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZYS4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYW8-1", "uniprot_id": [ { "id": "D3ZYW8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYW8", "type": "external" } ], "mass": 57974.0, "length": 529, "protein_name": "Transmembrane protein 266", "gene_name": "Tmem266", "organism": "Rat", "refseq_name": "transmembrane protein 266", "refseq_ac": [ { "id": "NP_001102764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102764", "type": "external" } ], "gene_names_uniprotkb": "Tmem266; RGD1562084", "gene_names_refseq": "RGD1562084; Tmem266", "protein_names_uniprotkb": "Transmembrane protein 266", "protein_names_refseq": "transmembrane protein 266; transmembrane protein C15orf27 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:501002)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZYW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZ04-1", "uniprot_id": [ { "id": "D3ZZ04_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZ04", "type": "external" } ], "mass": 36343.0, "length": 317, "protein_name": "Methyltransferase 9, His-X-His N1(pi)-histidine", "gene_name": "Mettl9", "organism": "Rat", "refseq_name": "protein-L-histidine N-pros-methyltransferase isoform X1", "refseq_ac": [ { "id": "XP_006230216", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006230216", "type": "external" } ], "gene_names_uniprotkb": "Mettl9", "gene_names_refseq": "Mettl9", "protein_names_uniprotkb": "Methyltransferase 9, His-X-His N1(pi)-histidine", "protein_names_refseq": "protein-L-histidine N-pros-methyltransferase isoform X1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0106370 protein-L-histidine N-pros-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZZ04-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZ37-1", "uniprot_id": [ { "id": "D3ZZ37_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZ37", "type": "external" } ], "mass": 48951.0, "length": 435, "protein_name": "Mitochondrial assembly of ribosomal large subunit protein 1", "gene_name": "Malsu1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Malsu1", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial assembly of ribosomal large subunit protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:297082); (R-RNO-9937383)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. May function as a ribosomal silencing factor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043023 ribosomal large subunit binding;GO:0140978 mitochondrial large ribosomal subunit binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0017148 negative regulation of translation;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0070130 negative regulation of mitochondrial translation;GO:0090071 negative regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZZ37-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZ77-1", "uniprot_id": [ { "id": "D3ZZ77_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZ77", "type": "external" } ], "mass": 35290.0, "length": 316, "protein_name": "Olfactory receptor", "gene_name": "Or51f2", "organism": "Rat", "refseq_name": "olfactory receptor Olr51", "refseq_ac": [ { "id": "NP_001001021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001021", "type": "external" } ], "gene_names_uniprotkb": "Or51f2", "gene_names_refseq": "Olr51; Or51f2", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 51F2-like; olfactory receptor 51F2; olfactory receptor 51; olfactory receptor Olr51; olfactory receptor gene Olr51", "tax_id": 10116, "disease": "", "pathway": " (rno:405904)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0071396 cellular response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZZ77-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZA3-1", "uniprot_id": [ { "id": "D3ZZA3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZA3", "type": "external" } ], "mass": 16232.0, "length": 140, "protein_name": "Cystatin-like 1", "gene_name": "Cstl1", "organism": "Rat", "refseq_name": "cystatin-like 1 precursor", "refseq_ac": [ { "id": "NP_001099992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099992", "type": "external" } ], "gene_names_uniprotkb": "Cstl1", "gene_names_refseq": "Cstl1", "protein_names_uniprotkb": "Cystatin-like 1", "protein_names_refseq": "cystatin-like 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:296220)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008234 cysteine-type peptidase activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "", "go_biological_process": "GO:0048678 response to axon injury;GO:0007431 salivary gland development;GO:0140448 signaling receptor ligand precursor processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZZA3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZA8-1", "uniprot_id": [ { "id": "D3ZZA8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZA8", "type": "external" } ], "mass": 118868.0, "length": 1089, "protein_name": "SEC24 homolog A, COPII coat complex component", "gene_name": "Sec24a", "organism": "Rat", "refseq_name": "protein transport protein Sec24A", "refseq_ac": [ { "id": "NP_001099250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099250", "type": "external" } ], "gene_names_uniprotkb": "Sec24a", "gene_names_refseq": "Sec24a", "protein_names_uniprotkb": "SEC24 homolog A, COPII coat complex component", "protein_names_refseq": "SEC24 family, member A; SEC24 homolog A, COPII coat complex component; SEC24 related gene family, member A; protein transport protein Sec24A", "tax_id": 10116, "disease": "", "pathway": " (rno:287275); (R-RNO-204005); (R-RNO-2132295); (R-RNO-5694530); (R-RNO-983170)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0050714 positive regulation of protein secretion;GO:0042632 cholesterol homeostasis;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZZA8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZL8-1", "uniprot_id": [ { "id": "D3ZZL8_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZL8", "type": "external" } ], "mass": 152989.0, "length": 1407, "protein_name": "Protein crumbs homolog 1", "gene_name": "Crb1", "organism": "Rat", "refseq_name": "protein crumbs homolog 1 precursor", "refseq_ac": [ { "id": "NP_001100652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100652", "type": "external" } ], "gene_names_uniprotkb": "Crb1", "gene_names_refseq": "Crb1", "protein_names_uniprotkb": "Protein crumbs homolog 1", "protein_names_refseq": "crumbs 1, cell polarity complex component; crumbs family member 1, photoreceptor morphogenesis associated; crumbs homolog 1; protein crumbs homolog 1 precursor", "tax_id": 10116, "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); Leber congenital amaurosis 8 (Disease Ontology:DOID:0110079); retinitis pigmentosa 12 (Disease Ontology:DOID:0110358); pigmented paravenous chorioretinal atrophy (Disease Ontology:DOID:0111541); retinitis pigmentosa (Disease Ontology:DOID:10584); Leber congenital amaurosis (Disease Ontology:DOID:14791); retinal disease (Disease Ontology:DOID:5679)", "pathway": " (rno:304825)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25878282;33808129", "class_list": "", "function": "Defining Phenotype, Tropism, and Retinal Gene Therapy Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats with a Spontaneous Mutation in Crb1. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study demonstrate that a new CRB1 rat mutation links Muller glial cells to retinal telangiectasia in rats., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0045177 apical part of cell", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0007009 plasma membrane organization;GO:0001974 blood vessel remodeling;GO:0061024 membrane organization;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZZL8-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZN7-1", "uniprot_id": [ { "id": "D3ZZN7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZN7", "type": "external" } ], "mass": 34541.0, "length": 313, "protein_name": "Olfactory receptor family 1 subfamily I member 2", "gene_name": "Or1i2", "organism": "Rat", "refseq_name": "olfactory receptor Olr1087", "refseq_ac": [ { "id": "NP_001000418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000418", "type": "external" } ], "gene_names_uniprotkb": "Or1i2; Olr1087", "gene_names_refseq": "Olr1087; Or1i2; ratchr7-12543995-12544936_ORF", "protein_names_uniprotkb": "Olfactory receptor family 1 subfamily I member 2", "protein_names_refseq": "olfactory receptor 1087; olfactory receptor Olr1087; olfactory receptor gene Olr1087", "tax_id": 10116, "disease": "", "pathway": " (rno:299586)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. 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Complex I functions in the transfer of electrons from NADH to the respiratory chain. 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LOC100359592", "gene_names_refseq": "Palm3", "protein_names_uniprotkb": "Paralemmin 3", "protein_names_refseq": "paralemmin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:100359592)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:0032496 response to lipopolysaccharide;GO:0008360 regulation of cell shape;GO:0008063 Toll signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A1J3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2D7-1", "uniprot_id": [ { "id": "D4A2D7_RAT", "url": "https://www.uniprot.org/uniprot/D4A2D7", "type": "external" } ], "mass": 118926.0, "length": 1081, "protein_name": "Importin 4", "gene_name": "Ipo4", "organism": "Rat", "refseq_name": "importin-4", "refseq_ac": [ { "id": "NP_001099508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099508", "type": "external" } ], "gene_names_uniprotkb": "Ipo4", "gene_names_refseq": "Ipo4", "protein_names_uniprotkb": "Importin 4", "protein_names_refseq": "importin-4", "tax_id": 10116, "disease": "", "pathway": " (rno:290228)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0034504 protein localization to nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A2D7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2H8-1", "uniprot_id": [ { "id": "D4A2H8_RAT", "url": "https://www.uniprot.org/uniprot/D4A2H8", "type": "external" } ], "mass": 51362.0, "length": 462, "protein_name": "NAD-capped RNA hydrolase NUDT12", "gene_name": "Nudt12", "organism": "Rat", "refseq_name": "NAD-capped RNA hydrolase NUDT12", "refseq_ac": [ { "id": "NP_001102480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102480", "type": "external" } ], "gene_names_uniprotkb": "Nudt12", "gene_names_refseq": "Nudt12", "protein_names_uniprotkb": "NAD-capped RNA hydrolase NUDT12; 3.6.1.22; NADH pyrophosphatase NUDT12; Nucleoside diphosphate-linked moiety X motif 12", "protein_names_refseq": "NAD-capped RNA hydrolase NUDT12; nudix (nucleoside diphosphate linked moiety X)-type motif 12; nudix-type motif 12; peroxisomal NADH pyrophosphatase NUDT12", "tax_id": 10116, "disease": "", "pathway": " (rno:367323); (R-RNO-196807)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress. Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.22", "type": "external" }, { "id": "2.7.7.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.2", "type": "external" }, { "id": "3.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0000210 NAD+ diphosphatase activity;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0035529 NADH pyrophosphatase activity;GO:1990174 phosphodiesterase decapping endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0006402 mRNA catabolic process;GO:0032922 circadian regulation of gene expression;GO:0006742 NADP+ catabolic process;GO:0110155 NAD-cap decapping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2H8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2I6-1", "uniprot_id": [ { "id": "D4A2I6_RAT", "url": "https://www.uniprot.org/uniprot/D4A2I6", "type": "external" } ], "mass": 18331.0, "length": 167, "protein_name": "Transmembrane protein 220", "gene_name": "Tmem220", "organism": "Rat", "refseq_name": "transmembrane protein 220 isoform 1", "refseq_ac": [ { "id": "NP_001292053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292053", "type": "external" } ], "gene_names_uniprotkb": "Tmem220", "gene_names_refseq": "RGD1309576; Tmem220", "protein_names_uniprotkb": "Transmembrane protein 220", "protein_names_refseq": "transmembrane protein 220 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:287405)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2I6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2S8-1", "uniprot_id": [ { "id": "D4A2S8_RAT", "url": "https://www.uniprot.org/uniprot/D4A2S8", "type": "external" } ], "mass": 85754.0, "length": 750, "protein_name": "SUMO specific peptidase 5", "gene_name": "Senp5", "organism": "Rat", "refseq_name": "sentrin-specific protease 5 isoform 1", "refseq_ac": [ { "id": "NP_001389087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001389087", "type": "external" } ], "gene_names_uniprotkb": "Senp5", "gene_names_refseq": "Senp5", "protein_names_uniprotkb": "SUMO specific peptidase 5", "protein_names_refseq": "SUMO/sentrin specific protease 5; SUMO1/sentrin specific peptidase 5; Sumo1/sentrin/SMT3 specific peptidase 5; sentrin-specific protease 5 isoform 1; sentrin-specific protease 5", "tax_id": 10116, "disease": "", "pathway": " (rno:103689978); (R-RNO-3065679)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "37403456", "class_list": "", "function": "SENP5 deteriorates traumatic brain injury via SUMO2-dependent suppression of E2F1 SUMOylation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016929 deSUMOylase activity;GO:0070139 SUMO-specific endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0099523 presynaptic cytosol;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016926 protein desumoylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A2S8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2S9-1", "uniprot_id": [ { "id": "D4A2S9_RAT", "url": "https://www.uniprot.org/uniprot/D4A2S9", "type": "external" } ], "mass": 23649.0, "length": 212, "protein_name": "Claudin 34E", "gene_name": "Cldn34e", "organism": "Rat", "refseq_name": "uncharacterized protein LOC680489", "refseq_ac": [ { "id": "NP_001102885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102885", "type": "external" } ], "gene_names_uniprotkb": "Cldn34e", "gene_names_refseq": "Cldn34e", "protein_names_uniprotkb": "Claudin 34E", "protein_names_refseq": "uncharacterized protein LOC680489", "tax_id": 10116, "disease": "", "pathway": " (rno:680489)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2S9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2V7-1", "uniprot_id": [ { "id": "D4A2V7_RAT", "url": "https://www.uniprot.org/uniprot/D4A2V7", "type": "external" } ], "mass": 67588.0, "length": 617, "protein_name": "F-box/WD repeat-containing protein 4", "gene_name": "Fbxw4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fbxw4", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box/WD repeat-containing protein 4; F-box and WD-40 domain-containing protein 4", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M0RCK6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0060173 limb development;GO:0042733 embryonic digit morphogenesis;GO:0051216 cartilage development;GO:0002053 positive regulation of mesenchymal cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A2V7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A2Y9-1", "uniprot_id": [ { "id": "PEX13_RAT", "url": "https://www.uniprot.org/uniprot/D4A2Y9", "type": "external" } ], "mass": 44264.0, "length": 403, "protein_name": "Peroxisomal membrane protein PEX13", "gene_name": "Pex13", "organism": "Rat", "refseq_name": "peroxisomal membrane protein PEX13", "refseq_ac": [ { "id": "NP_001100712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100712", "type": "external" } ], "gene_names_uniprotkb": "Pex13", "gene_names_refseq": "Pex13", "protein_names_uniprotkb": "Peroxisomal membrane protein PEX13; Peroxin-13", "protein_names_refseq": "peroxin-13; peroxisomal membrane protein PEX13; peroxisome biogenesis factor 13", "tax_id": 10116, "disease": "peroxisome biogenesis disorder 11A (Disease Ontology:DOID:0080485); Peroxisome biogenesis disorder 11B (Disease Ontology:DOID:0081439)", "pathway": " (rno:305581); (R-RNO-8866654); (R-RNO-9033241); (R-RNO-9603798)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "30414318", "class_list": "", "function": "Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Involved in the import of PTS1- and PTS2-type containing proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicate that PEX14 is a bona fide intrinsic membrane protein with a Nin -Cout topology, and that PEX13 adopts a Nout -Cin topology, thus exposing its carboxy-terminal Src homology 3 [SH3] domain into the organelle matrix, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6AVL0", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:1990429 peroxisomal importomer complex;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0001967 suckling behavior;GO:0007626 locomotory behavior;GO:0001764 neuron migration;GO:0021795 cerebral cortex cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A2Y9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A374-1", "uniprot_id": [ { "id": "D4A374_RAT", "url": "https://www.uniprot.org/uniprot/D4A374", "type": "external" } ], "mass": 28745.0, "length": 259, "protein_name": "Sesquipedalian", "gene_name": "Pheta2", "organism": "Rat", "refseq_name": "sesquipedalian-2", "refseq_ac": [ { "id": "NP_001123983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123983", "type": "external" } ], "gene_names_uniprotkb": "Pheta2; Fam109b", "gene_names_refseq": "Fam109b; Pheta2", "protein_names_uniprotkb": "Sesquipedalian; PH domain-containing endocytic trafficking adaptor; Ses", "protein_names_refseq": "family with sequence similarity 109, member B; sesquipedalian-2", "tax_id": 10116, "disease": "", "pathway": " (rno:688685)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6ASM9", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007032 endosome organization;GO:0001881 receptor recycling;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A374-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3U2-1", "uniprot_id": [ { "id": "D4A3U2_RAT", "url": "https://www.uniprot.org/uniprot/D4A3U2", "type": "external" } ], "mass": 27787.0, "length": 248, "protein_name": "Tetraspanin", "gene_name": "Tspan18", "organism": "Rat", "refseq_name": "tetraspanin-18", "refseq_ac": [ { "id": "NP_001101220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101220", "type": "external" } ], "gene_names_uniprotkb": "Tspan18", "gene_names_refseq": "RGD1560411; Tspan18", "protein_names_uniprotkb": "Tetraspanin", "protein_names_refseq": "tetraspanin-18", "tax_id": 10116, "disease": "", "pathway": " (rno:311210)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the cell surface localization of ORAI1 and may participate in the regulation of Ca(2+) signaling and the VWF release in response to inflammatory stimuli., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071944 cell periphery", "go_biological_process": "GO:1990778 protein localization to cell periphery;GO:0006954 inflammatory response;GO:0007599 hemostasis;GO:0017156 calcium-ion regulated exocytosis;GO:1903670 regulation of sprouting angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3U2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A3X9-1", "uniprot_id": [ { "id": "D4A3X9_RAT", "url": "https://www.uniprot.org/uniprot/D4A3X9", "type": "external" } ], "mass": 68068.0, "length": 598, "protein_name": "Zinc finger protein with KRAB and SCAN domains 8", "gene_name": "Zkscan8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zkscan8; Zfp192", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein with KRAB and SCAN domains 8; Zinc finger protein 192", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:306974); (R-RNO-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A3X9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A425-1", "uniprot_id": [ { "id": "D4A425_RAT", "url": "https://www.uniprot.org/uniprot/D4A425", "type": "external" } ], "mass": 119100.0, "length": 1069, "protein_name": "Caspase recruitment domain-containing protein 10", "gene_name": "Card10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Card10", "gene_names_refseq": "", "protein_names_uniprotkb": "Caspase recruitment domain-containing protein 10", "protein_names_refseq": "", "tax_id": 10116, "disease": "immunodeficiency 89 (Disease Ontology:DOID:0061059)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Scaffold protein that plays an important role in mediating the activation of NF-kappa-B via BCL10 or EGFR., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0007165 signal transduction;GO:0050776 regulation of immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A425-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A453-1", "uniprot_id": [ { "id": "D4A453_RAT", "url": "https://www.uniprot.org/uniprot/D4A453", "type": "external" } ], "mass": 51890.0, "length": 481, "protein_name": "E2 ubiquitin-conjugating enzyme", "gene_name": "Cdc34", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdc34", "gene_names_refseq": "", "protein_names_uniprotkb": "E2 ubiquitin-conjugating enzyme; 2.3.2.23", "protein_names_refseq": "", "tax_id": 10116, "disease": "azoospermia (Disease Ontology:DOID:14227); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:299602); (R-RNO-202424); (R-RNO-2871837); (R-RNO-5607764); (R-RNO-8866652); (R-RNO-983168)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A453-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A4E8-1", "uniprot_id": [ { "id": "D4A4E8_RAT", "url": "https://www.uniprot.org/uniprot/D4A4E8", "type": "external" } ], "mass": 33078.0, "length": 296, "protein_name": "Endonuclease III-like protein 1", "gene_name": "Nthl1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nthl1; NTHL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Endonuclease III-like protein 1; 3.2.2.-; 4.2.99.18; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycosylase/AP lyase", "protein_names_refseq": "", "tax_id": 10116, "disease": "familial adenomatous polyposis 3 (Disease Ontology:DOID:0080411)", "pathway": " (rno:29541); (R-RNO-110329); (R-RNO-110357)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006289 nucleotide-excision repair;GO:0006285 base-excision repair, AP site formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A4E8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A4V3-1", "uniprot_id": [ { "id": "D4A4V3_RAT", "url": "https://www.uniprot.org/uniprot/D4A4V3", "type": "external" } ], "mass": 38627.0, "length": 344, "protein_name": "KLF transcription factor 3", "gene_name": "Klf3", "organism": "Rat", "refseq_name": "Krueppel-like factor 3", "refseq_ac": [ { "id": "NP_001099212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099212", "type": "external" } ], "gene_names_uniprotkb": "Klf3", "gene_names_refseq": "Bklf; Klf3; Tef-2", "protein_names_uniprotkb": "KLF transcription factor 3", "protein_names_refseq": "Basic Kruppel- like factor; Krueppel-like factor 3; Kruppel like factor 3; Kruppel-like factor 3 (basic)", "tax_id": 10116, "disease": "", "pathway": " (rno:114845)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;39250818", "class_list": "", "function": "KLF3 impacts insulin sensitivity and glucose uptake in skeletal muscle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:1990859 cellular response to endothelin;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A4V3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A4W6-1", "uniprot_id": [ { "id": "D4A4W6_RAT", "url": "https://www.uniprot.org/uniprot/D4A4W6", "type": "external" } ], "mass": 17416.0, "length": 156, "protein_name": "SRA stem-loop-interacting RNA-binding protein, mitochondrial", "gene_name": "Slirp", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slirp", "gene_names_refseq": "", "protein_names_uniprotkb": "SRA stem-loop-interacting RNA-binding protein, mitochondrial", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0007338 single fertilization;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A4W6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A526-1", "uniprot_id": [ { "id": "D4A526_RAT", "url": "https://www.uniprot.org/uniprot/D4A526", "type": "external" } ], "mass": 16598.0, "length": 151, "protein_name": "Leukocyte cell-derived chemotaxin-2", "gene_name": "Lect2", "organism": "Rat", "refseq_name": "leukocyte cell-derived chemotaxin-2 precursor", "refseq_ac": [ { "id": "NP_001101875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101875", "type": "external" } ], "gene_names_uniprotkb": "Lect2", "gene_names_refseq": "Lect2", "protein_names_uniprotkb": "Leukocyte cell-derived chemotaxin-2", "protein_names_refseq": "leukocyte cell-derived chemotaxin-2 precursor", "tax_id": 10116, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:361205)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A526-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A563-1", "uniprot_id": [ { "id": "D4A563_RAT", "url": "https://www.uniprot.org/uniprot/D4A563", "type": "external" } ], "mass": 191112.0, "length": 1733, "protein_name": "Inactive tyrosine-protein kinase PEAK1", "gene_name": "Peak1", "organism": "Rat", "refseq_name": "inactive tyrosine-protein kinase PEAK1", "refseq_ac": [ { "id": "NP_001101619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101619", "type": "external" } ], "gene_names_uniprotkb": "Peak1; RGD1312026", "gene_names_refseq": "Peak1; RGD1312026", "protein_names_uniprotkb": "Inactive tyrosine-protein kinase PEAK1; Pseudopodium-enriched atypical kinase 1; Sugen kinase 269; Tyrosine-protein kinase SgK269", "protein_names_refseq": "inactive tyrosine-protein kinase PEAK1", "tax_id": 10116, "disease": "", "pathway": " (rno:315686); (R-RNO-9013420); (R-RNO-9013424)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16641100;22673903", "class_list": "", "function": "Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0042802 identical protein binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0016477 cell migration;GO:2000145 regulation of cell motility;GO:0046777 protein autophosphorylation;GO:0034446 substrate adhesion-dependent cell spreading", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4A563-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6H3-1", "uniprot_id": [ { "id": "D4A6H3_RAT", "url": "https://www.uniprot.org/uniprot/D4A6H3", "type": "external" } ], "mass": 55792.0, "length": 489, "protein_name": "STEAP2 metalloreductase", "gene_name": "Steap2", "organism": "Rat", "refseq_name": "metalloreductase STEAP2 isoform 1", "refseq_ac": [ { "id": "NP_001101316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101316", "type": "external" } ], "gene_names_uniprotkb": "Steap2", "gene_names_refseq": "Steap2", "protein_names_uniprotkb": "STEAP2 metalloreductase", "protein_names_refseq": "STEAP family member 2, metalloreductase; metalloreductase STEAP2 isoform 1; metalloreductase STEAP2; six transmembrane epithelial antigen of prostate 2; six transmembrane epithelial antigen of the prostate 2", "tax_id": 10116, "disease": "", "pathway": " (rno:312052)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008823 cupric reductase (NADH) activity;GO:0052851 ferric-chelate reductase (NADPH) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0045055 regulated exocytosis;GO:0009725 response to hormone;GO:0015677 copper ion import;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A6H3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6K7-1", "uniprot_id": [ { "id": "D4A6K7_RAT", "url": "https://www.uniprot.org/uniprot/D4A6K7", "type": "external" } ], "mass": 41081.0, "length": 359, "protein_name": "Leucine-rich repeat-containing protein 19", "gene_name": "Lrrc19", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 19 precursor", "refseq_ac": [ { "id": "NP_001102883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102883", "type": "external" } ], "gene_names_uniprotkb": "Lrrc19", "gene_names_refseq": "Lrrc19", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 19", "protein_names_refseq": "leucine-rich repeat-containing protein 19 precursor; leucine-rich repeat-containing protein 19", "tax_id": 10116, "disease": "", "pathway": " (rno:680478)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines. In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances. In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0050727 regulation of inflammatory response;GO:0001817 regulation of cytokine production;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A6K7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6L5-1", "uniprot_id": [ { "id": "D4A6L5_RAT", "url": "https://www.uniprot.org/uniprot/D4A6L5", "type": "external" } ], "mass": 61663.0, "length": 554, "protein_name": "Zinc finger and SCAN domain containing 25", "gene_name": "Zscan25", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zscan25; Zfp498", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger and SCAN domain containing 25", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-212436)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A6L5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A6T5-1", "uniprot_id": [ { "id": "D4A6T5_RAT", "url": "https://www.uniprot.org/uniprot/D4A6T5", "type": "external" } ], "mass": 28127.0, "length": 263, "protein_name": "Copper homeostasis protein cutC homolog", "gene_name": "Cutc", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cutc", "gene_names_refseq": "", "protein_names_uniprotkb": "Copper homeostasis protein cutC homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:361760)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in copper homeostasis. Can bind one Cu(1+) per subunit., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051262 protein tetramerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A6T5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7C0-1", "uniprot_id": [ { "id": "GPN2_RAT", "url": "https://www.uniprot.org/uniprot/D4A7C0", "type": "external" } ], "mass": 34393.0, "length": 310, "protein_name": "GPN-loop GTPase 2", "gene_name": "Gpn2", "organism": "Rat", "refseq_name": "GPN-loop GTPase 2", "refseq_ac": [ { "id": "NP_001257888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257888", "type": "external" } ], "gene_names_uniprotkb": "Gpn2; Atpbd1B", "gene_names_refseq": "Atpbd1b; Gpn2; RGD1311749", "protein_names_uniprotkb": "GPN-loop GTPase 2; 3.6.5.-; ATP-binding domain 1 family member B", "protein_names_refseq": "ATP-binding domain 1 family member B; GPN-loop GTPase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:362614)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTPase involved in the correct assembly of RNA polymerase RNA polymerase II and III (RNAPII and RNAPIII) complexes, ensuring their proper nuclear import., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A7C0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7C3-1", "uniprot_id": [ { "id": "D4A7C3_RAT", "url": "https://www.uniprot.org/uniprot/D4A7C3", "type": "external" } ], "mass": 41557.0, "length": 380, "protein_name": "N-acetylaspartylglutamate synthase", "gene_name": "Rimkla", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rimkla", "gene_names_refseq": "", "protein_names_uniprotkb": "N-acetylaspartylglutamate synthase; 6.3.2.41", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-8964539)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.2.41", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.41", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A7C3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7L8-1", "uniprot_id": [ { "id": "D4A7L8_RAT", "url": "https://www.uniprot.org/uniprot/D4A7L8", "type": "external" } ], "mass": 12057.0, "length": 110, "protein_name": "Secreted Ly6/Plaur domain containing 1", "gene_name": "Slurp1", "organism": "Rat", "refseq_name": "secreted Ly-6/uPAR-related protein 1 precursor", "refseq_ac": [ { "id": "NP_001124016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124016", "type": "external" } ], "gene_names_uniprotkb": "Slurp1", "gene_names_refseq": "RGD1308768; Slurp1", "protein_names_uniprotkb": "Secreted Ly6/Plaur domain containing 1", "protein_names_refseq": "secreted Ly-6/uPAR-related protein 1 precursor; secreted Ly-6/uPAR-related protein 1", "tax_id": 10116, "disease": "mal de Meleda (Disease Ontology:DOID:0060862); palmoplantar keratosis (Disease Ontology:DOID:3390)", "pathway": " (rno:300016)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19409425", "class_list": "", "function": "These findings suggest that SLURP-1 is expressed in a subset of primary peptidergic sensory neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030549 acetylcholine receptor activator activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0038195 urokinase plasminogen activator signaling pathway;GO:0007626 locomotory behavior;GO:0008285 negative regulation of cell population proliferation;GO:0030336 negative regulation of cell migration;GO:0010839 negative regulation of keratinocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A7L8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7N1-1", "uniprot_id": [ { "id": "MIC25_RAT", "url": "https://www.uniprot.org/uniprot/D4A7N1", "type": "external" } ], "mass": 29211.0, "length": 261, "protein_name": "MICOS complex subunit Mic25", "gene_name": "Chchd6", "organism": "Rat", "refseq_name": "MICOS complex subunit Mic25", "refseq_ac": [ { "id": "NP_001100078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100078", "type": "external" } ], "gene_names_uniprotkb": "Chchd6; Mic25", "gene_names_refseq": "Chchd6", "protein_names_uniprotkb": "MICOS complex subunit Mic25; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6", "protein_names_refseq": "MICOS complex subunit Mic25; coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial", "tax_id": 10116, "disease": "hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (rno:297436)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0061617 MICOS complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4A7N1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A7P2-1", "uniprot_id": [ { "id": "LRRT2_RAT", "url": "https://www.uniprot.org/uniprot/D4A7P2", "type": "external" } ], "mass": 58804.0, "length": 515, "protein_name": "Leucine-rich repeat transmembrane neuronal protein 2", "gene_name": "Lrrtm2", "organism": "Rat", "refseq_name": "leucine-rich repeat transmembrane neuronal protein 2 precursor", "refseq_ac": [ { "id": "NP_001102939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102939", "type": "external" } ], "gene_names_uniprotkb": "Lrrtm2", "gene_names_refseq": "Lrrtm2", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane neuronal protein 2; 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Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. 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Smc6", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 6", "protein_names_refseq": "SMC6 structural maintenance of chromosomes 6-like 1; structural maintenance of chromosomes protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:313961); (R-RNO-3108214)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003684 damaged DNA binding;GO:0016887 ATP hydrolysis activity;GO:0031625 ubiquitin protein ligase binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000775 chromosome, centromeric region;GO:0016605 PML body", "go_biological_process": "GO:0051984 positive regulation of chromosome segregation;GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination;GO:0090398 cellular senescence;GO:0000722 telomere maintenance via recombination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4AB26-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AB67-1", "uniprot_id": [ { "id": "D4AB67_RAT", "url": "https://www.uniprot.org/uniprot/D4AB67", "type": "external" } ], "mass": 12529.0, "length": 106, "protein_name": "Histidine rich carboxyl terminus 1", "gene_name": "Hrct1", "organism": "Rat", "refseq_name": "histidine-rich carboxyl terminus protein 1", "refseq_ac": [ { "id": "NP_001385982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385982", "type": "external" } ], "gene_names_uniprotkb": "Hrct1", "gene_names_refseq": "Hrct1", "protein_names_uniprotkb": "Histidine rich carboxyl terminus 1", "protein_names_refseq": "histidine-rich carboxyl terminus protein 1; rCG54747-like", "tax_id": 10116, "disease": "", "pathway": " (rno:100359865)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AB67-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ABP8-1", "uniprot_id": [ { "id": "D4ABP8_RAT", "url": "https://www.uniprot.org/uniprot/D4ABP8", "type": "external" } ], "mass": 237897.0, "length": 2125, "protein_name": "Oxygen-regulated protein 1", "gene_name": "Rp1", "organism": "Rat", "refseq_name": "oxygen-regulated protein 1", "refseq_ac": [ { "id": "NP_001182605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182605", "type": "external" } ], "gene_names_uniprotkb": "Rp1", "gene_names_refseq": "RGD1560182; Rp1h; Rp1", "protein_names_uniprotkb": "Oxygen-regulated protein 1", "protein_names_refseq": "lipoxygenase homology domain-containing protein 1; oxygen-regulated protein 1; rCG30348-like; retinitis pigmentosa 1 (autosomal dominant); retinitis pigmentosa 1 homolog", "tax_id": 10116, "disease": "retinitis pigmentosa 1 (Disease Ontology:DOID:0110390)", "pathway": " (rno:681377)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme., [UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains, which bind microtubules and regulate microtubule polymerization. The encoded protein is a photoreceptor microtubule-associated protein and is required for correct stacking of outer segment disc. This protein and the RP1L1 protein, another retinal-specific protein, play essential and synergistic roles in affecting photosensitivity and outer segment morphogenesis of rod photoreceptors. Because of its response to in vivo retinal oxygen levels, this protein was initially named ORP1 (oxygen-regulated protein-1). This protein was subsequently designated RP1 (retinitis pigmentosa 1) when it was found that mutations in this gene cause autosomal dominant retinitis pigmentosa. Mutations in this gene also cause autosomal recessive retinitis pigmentosa. [provided by RefSeq, Sep 2010]., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005929 cilium;GO:0001917 photoreceptor inner segment;GO:0005875 microtubule associated complex;GO:0005930 axoneme", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ABP8-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AC07-1", "uniprot_id": [ { "id": "D4AC07_RAT", "url": "https://www.uniprot.org/uniprot/D4AC07", "type": "external" } ], "mass": 79329.0, "length": 698, "protein_name": "Zinc finger, SWIM-type containing 3", "gene_name": "Zswim3", "organism": "Rat", "refseq_name": "zinc finger SWIM domain-containing protein 3", "refseq_ac": [ { "id": "NP_001101271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101271", "type": "external" } ], "gene_names_uniprotkb": "Zswim3", "gene_names_refseq": "Zswim3", "protein_names_uniprotkb": "Zinc finger, SWIM-type containing 3", "protein_names_refseq": "zinc finger SWIM domain-containing protein 3; zinc finger, SWIM domain containing 3", "tax_id": 10116, "disease": "", "pathway": " (rno:311630)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AC07-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AC65-1", "uniprot_id": [ { "id": "D4AC65_RAT", "url": "https://www.uniprot.org/uniprot/D4AC65", "type": "external" } ], "mass": 25711.0, "length": 231, "protein_name": "Cytochrome c oxidase assembly factor 7", "gene_name": "Coa7", "organism": "Rat", "refseq_name": "sel1 repeat-containing protein 1", "refseq_ac": [ { "id": "NP_001100144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100144", "type": "external" } ], "gene_names_uniprotkb": "Coa7; Selrc1", "gene_names_refseq": "Coa7; RGD1305274; Selrc1", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor 7", "protein_names_refseq": "Sel1 repeat containing 1; sel1 repeat-containing protein 1", "tax_id": 10116, "disease": "autosomal recessive spinocerebellar ataxia with axonal neuropathy 3 (Disease Ontology:DOID:0070465)", "pathway": " (rno:298377)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for assembly of mitochondrial respiratory chain complex I and complex IV., [UniProtKB, UniProtKB]; Required for assembly of mitochondrial respiratory chain complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0008535 respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AC65-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AC95-1", "uniprot_id": [ { "id": "D4AC95_RAT", "url": "https://www.uniprot.org/uniprot/D4AC95", "type": "external" } ], "mass": 94195.0, "length": 845, "protein_name": "Centrosomal protein of 97 kDa", "gene_name": "Cep97", "organism": "Rat", "refseq_name": "centrosomal protein of 97 kDa", "refseq_ac": [ { "id": "NP_001100566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100566", "type": "external" } ], "gene_names_uniprotkb": "Cep97", "gene_names_refseq": "Cep97; Lrriq2; RGD1307400", "protein_names_uniprotkb": "Centrosomal protein of 97 kDa; Leucine-rich repeat and IQ domain-containing protein 2", "protein_names_refseq": "centrosomal protein 97kDa; centrosomal protein of 97 kDa; leucine-rich repeats and IQ motif containing 2", "tax_id": 10116, "disease": "", "pathway": " (rno:304007); (R-RNO-5620912); (R-RNO-9013424)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole;GO:0032991 protein-containing complex", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0030030 cell projection organization;GO:1901673 regulation of mitotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D4AC95-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACG2-1", "uniprot_id": [ { "id": "D4ACG2_RAT", "url": "https://www.uniprot.org/uniprot/D4ACG2", "type": "external" } ], "mass": 72270.0, "length": 672, "protein_name": "2-hydroxyacyl-CoA lyase 2", "gene_name": "Hacl2", "organism": "Rat", "refseq_name": "2-hydroxyacyl-CoA lyase 2", "refseq_ac": [ { "id": "NP_001102208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102208", "type": "external" } ], "gene_names_uniprotkb": "Hacl2; Ilvbl", "gene_names_refseq": "Hacl2; Ilvbl", "protein_names_uniprotkb": "2-hydroxyacyl-CoA lyase 2; Acetolactate synthase-like protein; IlvB-like protein", "protein_names_refseq": "2-hydroxyacyl-CoA lyase 2; acetolactate synthase-like protein; ilvB (bacterial acetolactate synthase)-like; ilvB acetolactate synthase like", "tax_id": 10116, "disease": "", "pathway": " (rno:362843)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0016829 lyase activity;GO:0030976 thiamine pyrophosphate binding;GO:0003984 acetolactate synthase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005948 acetolactate synthase complex", "go_biological_process": "GO:0001561 fatty acid alpha-oxidation;GO:0009099 L-valine biosynthetic process;GO:0009097 isoleucine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ACG2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACH7-1", "uniprot_id": [ { "id": "D4ACH7_RAT", "url": "https://www.uniprot.org/uniprot/D4ACH7", "type": "external" } ], "mass": 52820.0, "length": 464, "protein_name": "PRAME like, X-linked 1", "gene_name": "Pramex1", "organism": "Rat", "refseq_name": "PRAME like, X-linked 1", "refseq_ac": [ { "id": "NP_001420085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001420085", "type": "external" } ], "gene_names_uniprotkb": "Pramex1; LOC100365087", "gene_names_refseq": "Pramex1; Prame", "protein_names_uniprotkb": "PRAME like, X-linked 1", "protein_names_refseq": "PRAME like, X-linked 1; PRAME nuclear receptor transcriptional regulator; melanoma antigen preferentially expressed in tumors; preferentially expressed antigen in melanoma; rCG38045-like", "tax_id": 10116, "disease": "mantle cell lymphoma (Disease Ontology:DOID:0050746); myelodysplastic syndrome (Disease Ontology:DOID:0050908); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); osteosarcoma (Disease Ontology:DOID:3347); ovary adenocarcinoma (Disease Ontology:DOID:3713); lung adenocarcinoma (Disease Ontology:DOID:3910); uveal melanoma (Disease Ontology:DOID:6039); neuroblastoma (Disease Ontology:DOID:769); chronic myeloid leukemia (Disease Ontology:DOID:8552); Hodgkin's lymphoma (Disease Ontology:DOID:8567); myeloid leukemia (Disease Ontology:DOID:8692); acute megakaryocytic leukemia (Disease Ontology:DOID:8761); 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3.5.4.34; tRNA-specific adenosine-37 deaminase", "protein_names_refseq": "tRNA-specific adenosine deaminase 1 isoform 1; tRNA-specific adenosine deaminase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:690810)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specifically deaminates adenosine-37 to inosine in tRNA-Ala., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.34", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0008251 tRNA-specific adenosine deaminase activity;GO:0046872 metal ion binding;GO:0043829 tRNA-specific adenosine-37 deaminase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ADL5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ADP4-1", "uniprot_id": [ { "id": "D4ADP4_RAT", "url": "https://www.uniprot.org/uniprot/D4ADP4", "type": "external" } ], "mass": 107712.0, "length": 938, "protein_name": "Family with sequence similarity 186, member B", "gene_name": "Fam186b", "organism": "Rat", "refseq_name": "protein FAM186B", "refseq_ac": [ { "id": "NP_001128105", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128105", "type": "external" } ], "gene_names_uniprotkb": "Fam186b", "gene_names_refseq": "Fam186b; RGD1559522", "protein_names_uniprotkb": "Family with sequence similarity 186, member B", "protein_names_refseq": "protein FAM186B", "tax_id": 10116, "disease": "", "pathway": " (rno:500931)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032991 protein-containing complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ADP4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PSK7-1", "uniprot_id": [ { "id": "JIP3_RAT", "url": "https://www.uniprot.org/uniprot/E9PSK7", "type": "external" } ], "mass": 145650.0, "length": 1322, "protein_name": "C-Jun-amino-terminal kinase-interacting protein 3", "gene_name": "Mapk8ip3", "organism": "Rat", "refseq_name": "C-Jun-amino-terminal kinase-interacting protein 3", "refseq_ac": [ { "id": "NP_001094143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094143", "type": "external" } ], "gene_names_uniprotkb": "Mapk8ip3; Jip3", "gene_names_refseq": "JIP-3; JIP3; JSAP1; Mapk8ip3", "protein_names_uniprotkb": "C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3", "protein_names_refseq": "C-Jun-amino-terminal kinase-interacting protein 3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:302983)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "21076496;21775604;22128169;22673903;23576431;25644797;25944905;29159770", "class_list": "", "function": "Diabetes seems to change spinal cord KIF5B and SYD mRNA and sciatic nerves KIF5B content and exercise training modifies it, which may be attributable to the training-induced decreased hyperglycemia., [RefSeq, PubMed]; JIP3 regulates neuronal axon elongation in a kinesin- and JNK-dependent manner, [RefSeq, PubMed]; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development. Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; These observations indicate that JIP3 may be involved in transporting vesicular cargoes to the growth cones of PC12 cells, possibly targeting JNK to its substrate paxillin, and thus facilitating neurite outgrowth. Erratum:[Mol Cell Biochem. 2018 Jul;444(1-2):15. doi: 10.1007/s11010-018-3354-4. PMID: 29725980], [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B0VXR4", "ec_number_list": [], "go_molecular_function": "GO:0031434 mitogen-activated protein kinase kinase binding;GO:0019894 kinesin binding;GO:0005078 MAP-kinase scaffold activity;GO:0030159 signaling receptor complex adaptor activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0099641 anterograde axonal protein transport;GO:0001701 in utero embryonic development;GO:0030900 forebrain development;GO:0031175 neuron projection development;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "E9PSK7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E9PT53-1", "uniprot_id": [ { "id": "E9PT53_RAT", "url": "https://www.uniprot.org/uniprot/E9PT53", "type": "external" } ], "mass": 105861.0, "length": 943, "protein_name": "Wolframin", "gene_name": "Wfs1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wfs1", "gene_names_refseq": "", "protein_names_uniprotkb": "Wolframin", "protein_names_refseq": "", "tax_id": 10116, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); autosomal dominant Wolfram syndrome (Disease Ontology:DOID:0080584); cataract 41 (Disease Ontology:DOID:0110241); autosomal dominant nonsyndromic deafness 6 (Disease Ontology:DOID:0110584); Wolfram syndrome 1 (Disease Ontology:DOID:0110629); optic atrophy 1 (Disease Ontology:DOID:0111441); sensorineural hearing loss (Disease Ontology:DOID:10003); glucose intolerance (Disease Ontology:DOID:10603); Wolfram syndrome (Disease Ontology:DOID:10632); post-traumatic stress disorder (Disease Ontology:DOID:2055); optic atrophy (Disease Ontology:DOID:5723); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0048306 calcium-dependent protein binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0030141 secretory granule;GO:0005789 endoplasmic reticulum membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:1903892 negative regulation of ATF6-mediated unfolded protein response;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0003091 renal water homeostasis;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "E9PT53-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LN63-1", "uniprot_id": [ { "id": "F1LN63_RAT", "url": "https://www.uniprot.org/uniprot/F1LN63", "type": "external" } ], "mass": 103015.0, "length": 905, "protein_name": "Toll-like receptor 3", "gene_name": "Tlr3", "organism": "Rat", "refseq_name": "toll-like receptor 3 precursor", "refseq_ac": [ { "id": "NP_942086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942086", "type": "external" } ], "gene_names_uniprotkb": "Tlr3", "gene_names_refseq": "Tlr3", "protein_names_uniprotkb": "Toll-like receptor 3", "protein_names_refseq": "toll-like receptor 3 precursor", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); colitis (Disease Ontology:DOID:0060180); critical COVID-19 (Disease Ontology:DOID:0081012); severe COVID-19 (Disease Ontology:DOID:0081013); pre-eclampsia (Disease Ontology:DOID:10591); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); anogenital venereal wart (Disease Ontology:DOID:11168); Behcet's disease (Disease Ontology:DOID:13241); colon carcinoma (Disease Ontology:DOID:1520); alcohol use disorder (Disease Ontology:DOID:1574); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); asthma (Disease Ontology:DOID:2841); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); eye disease (Disease Ontology:DOID:5614); peripheral nervous system disease (Disease Ontology:DOID:574); primary immunodeficiency disease (Disease Ontology:DOID:612); hepatocellular carcinoma (Disease Ontology:DOID:684); autoimmune thyroiditis (Disease Ontology:DOID:7188); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:364594)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "34015428;36334783", "class_list": "", "function": "Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response., [UniProtKB, UniProtKB, UniProtKB]; TLR2- and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner., [RefSeq, PubMed]; Toll-like receptor 3 neuroimmune signaling and behavior change: A strain comparison between Lewis and Wistar rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0003725 double-stranded RNA binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:0002730 regulation of dendritic cell cytokine production;GO:0034346 positive regulation of type III interferon production;GO:0001774 microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1LN63-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LQF7-1", "uniprot_id": [ { "id": "F1LQF7_RAT", "url": "https://www.uniprot.org/uniprot/F1LQF7", "type": "external" } ], "mass": 110349.0, "length": 958, "protein_name": "Transient receptor potential cation channel, subfamily C, member 7", "gene_name": "Trpc7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trpc7", "gene_names_refseq": "", "protein_names_uniprotkb": "Transient receptor potential cation channel, subfamily C, member 7", "protein_names_refseq": "", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (rno:282822); (R-RNO-114508); (R-RNO-139853); (R-RNO-3295583)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005262 calcium channel activity;GO:0005261 monoatomic cation channel activity;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007338 single fertilization;GO:0070588 calcium ion transmembrane transport;GO:0006828 manganese ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LQF7-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LUQ5-1", "uniprot_id": [ { "id": "F1LUQ5_RAT", "url": "https://www.uniprot.org/uniprot/F1LUQ5", "type": "external" } ], "mass": 97012.0, "length": 861, "protein_name": "Protein argonaute-4", "gene_name": "Ago4", "organism": "Rat", "refseq_name": "protein argonaute-4", "refseq_ac": [ { "id": "NP_001381300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001381300", "type": "external" } ], "gene_names_uniprotkb": "Ago4; AGO4; EIF2C4", "gene_names_refseq": "Ago4; Eif2c4", "protein_names_uniprotkb": "Protein argonaute-4; Argonaute4; Eukaryotic translation initiation factor 2C 4; eIF-2C 4; eIF2C 4", "protein_names_refseq": "argonaute 4, RISC catalytic component; argonaute RISC catalytic component 4; eukaryotic translation initiation factor 2C, 4; protein argonaute-4-like; protein argonaute-4", "tax_id": 10116, "disease": "", "pathway": " (rno:298533); (R-RNO-203927); (R-RNO-426486); (R-RNO-426496)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0035198 miRNA binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0016442 RISC complex", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0043066 negative regulation of apoptotic process;GO:0008584 male gonad development;GO:0006402 mRNA catabolic process;GO:0007130 synaptonemal complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LUQ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21139-1", "uniprot_id": [ { "id": "MA2C1_RAT", "url": "https://www.uniprot.org/uniprot/P21139", "type": "external" } ], "mass": 115971.0, "length": 1040, "protein_name": "Alpha-mannosidase 2C1", "gene_name": "Man2c1", "organism": "Rat", "refseq_name": "alpha-mannosidase 2C1", "refseq_ac": [ { "id": "NP_640349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_640349", "type": "external" } ], "gene_names_uniprotkb": "Man2c1", "gene_names_refseq": "AMAN; Man2c1", "protein_names_uniprotkb": "Alpha-mannosidase 2C1; 3.2.1.24; Alpha-D-mannoside mannohydrolase; Mannosidase alpha class 2C member 1", "protein_names_refseq": "alpha-D-mannoside mannohydrolase; alpha-mannosidase 2C1", "tax_id": 10116, "disease": "congenital disorder of deglycosylation 2 (Disease Ontology:DOID:0060990)", "pathway": " (rno:246136); (R-RNO-8853383)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2211613", "class_list": "glycogene;glycosylhydrolase", "function": "Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins (PubMed:2211613). Involved in the degradation of free oligosaccharides in the cytoplasm (By similarity)., [UniProtKB, UniProtKB, PubMed]; Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006013 mannose metabolic process;GO:0009313 oligosaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P21139-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM98-1", "uniprot_id": [ { "id": "MFF_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM98", "type": "external" } ], "mass": 24971.0, "length": 218, "protein_name": "Mitochondrial fission factor", "gene_name": "Mff", "organism": "Rat", "refseq_name": "mitochondrial fission factor isoform 2", "refseq_ac": [ { "id": "NP_001034104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034104", "type": "external" } ], "gene_names_uniprotkb": "Mff", "gene_names_refseq": "Mff; RGD1310230", "protein_names_uniprotkb": "Mitochondrial fission factor", "protein_names_refseq": "mitochondrial fission factor isoform 2", "tax_id": 10116, "disease": "encephalopathy due to defective mitochondrial and peroxisomal fission 2 (Disease Ontology:DOID:0060994); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:301563)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16641100;22673903;23792689;23867156", "class_list": "", "function": "Plays a role in mitochondrial and peroxisomal fission (By similarity). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (By similarity). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (PubMed:23792689)., [UniProtKB, UniProtKB, PubMed]; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study reveals a novel model of mitochondrial fission regulation, which is composed of miR-761 and mitochondrial fission factor, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0031966 mitochondrial membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0016559 peroxisome fission;GO:0006626 protein targeting to mitochondrion;GO:0070301 cellular response to hydrogen peroxide;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4KM98-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54697-1", "uniprot_id": [ { "id": "NALDL_RAT", "url": "https://www.uniprot.org/uniprot/O54697", "type": "external" } ], "mass": 80641.0, "length": 745, "protein_name": "Aminopeptidase NAALADL1", "gene_name": "Naaladl1", "organism": "Rat", "refseq_name": "aminopeptidase NAALADL1", "refseq_ac": [ { "id": "NP_113947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113947", "type": "external" } ], "gene_names_uniprotkb": "Naaladl1; Naaladl", "gene_names_refseq": "I100; Naaladasel; Naaladl1", "protein_names_uniprotkb": "Aminopeptidase NAALADL1; 100 kDa ileum brush border membrane protein; 3.4.11.-; I100; Ileal dipeptidylpeptidase; N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L", "protein_names_refseq": "100 kDa ileum brush border membrane protein; N-acetylated alpha-linked acidic dipeptidase-like (ileal peptidase I100); N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L; aminopeptidase NAALADL1; ileal dipeptidylpeptidase; ileal peptidase I100", "tax_id": 10116, "disease": "", "pathway": " (rno:83568)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9388249", "class_list": "", "function": "Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0004180 carboxypeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O54697-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q497C3-1", "uniprot_id": [ { "id": "MTL26_RAT", "url": "https://www.uniprot.org/uniprot/Q497C3", "type": "external" } ], "mass": 22612.0, "length": 204, "protein_name": "Methyltransferase-like 26", "gene_name": "Mettl26", "organism": "Rat", "refseq_name": "methyltransferase-like 26 isoform 2", "refseq_ac": [ { "id": "NP_001032265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032265", "type": "external" } ], "gene_names_uniprotkb": "Mettl26", "gene_names_refseq": "Mettl26; RGD1307155", "protein_names_uniprotkb": "Methyltransferase-like 26", "protein_names_refseq": "UPF0585 protein C16orf13 homolog; methyltransferase-like 26 isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:302998)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q497C3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50280-1", "uniprot_id": [ { "id": "MMP7_RAT", "url": "https://www.uniprot.org/uniprot/P50280", "type": "external" } ], "mass": 29885.0, "length": 267, "protein_name": "Matrilysin", "gene_name": "Mmp7", "organism": "Rat", "refseq_name": "matrilysin precursor", "refseq_ac": [ { "id": "NP_036996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036996", "type": "external" } ], "gene_names_uniprotkb": "Mmp7; Mmp-7", "gene_names_refseq": "MPMM; Mmp7", "protein_names_uniprotkb": "Matrilysin; 3.4.24.23; MMP-7; Matrin; Matrix metalloproteinase-7; Pump-1 protease; Uterine metalloproteinase", "protein_names_refseq": "MMP-7; Matrix metalloproteinase 7 (matrilysin); matrilysin precursor; matrilysin; matrin; matrix metalloproteinase-7; pump-1 protease; uterine metalloproteinase", "tax_id": 10116, "disease": "endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); endometrial cancer (Disease Ontology:DOID:1380); bladder neck obstruction (Disease Ontology:DOID:13948); glioblastoma (Disease Ontology:DOID:3068); lung non-small cell carcinoma (Disease Ontology:DOID:3908); coronary restenosis (Disease Ontology:DOID:4247)", "pathway": " (rno:25335); (R-RNO-1442490); (R-RNO-1474228); (R-RNO-1592389); (R-RNO-2022090); (R-RNO-9009391)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10660581;28626073;31493243;31791378;38643908;7608162", "class_list": "", "function": "Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase (By similarity)., [UniProtKB]; Increased Mmp/Reck Expression Ratio Is Associated with Increased Recognition Memory Performance in a Parkinson's Disease Animal Model., [RefSeq, PubMed]; Increased uterine arterial tone, stiffness and remodeling with augmented matrix metalloproteinase-1 and -7 in uteroplacental ischemia-induced hypertensive pregnancy., [RefSeq, PubMed]; Placental ischemia, possibly through the release of TNF-alpha, causes increases in the levels of matrix metalloproteinase (MMP)-1 and MMP-7, which could alter collagen deposition and cause inadequate uteroplacental and vascular remodeling in hypertension in pregnancy., [RefSeq, PubMed]; The promoting effect of MMP7 on Schwann cell migration and peripheral nerve regeneration, is reported. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis;GO:0030198 extracellular matrix organization;GO:0030335 positive regulation of cell migration;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P50280-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68943-1", "uniprot_id": [ { "id": "MED28_RAT", "url": "https://www.uniprot.org/uniprot/P68943", "type": "external" } ], "mass": 19524.0, "length": 178, "protein_name": "Mediator of RNA polymerase II transcription subunit 28", "gene_name": "Med28", "organism": "Rat", "refseq_name": "mediator of RNA polymerase II transcription subunit 28", "refseq_ac": [ { "id": "NP_001100687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100687", "type": "external" } ], "gene_names_uniprotkb": "Med28", "gene_names_refseq": "Eg1; FKSG20; Med28; RGD1305875", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 28; Mediator complex subunit 28", "protein_names_refseq": "endothelial-derived; mediator of RNA polymerase II transcription subunit 28; mediator of RNA polymerase II transcription, subunit 28 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:305391)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12149480", "class_list": "", "function": "May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0019827 stem cell population maintenance;GO:0051151 negative regulation of smooth muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P68943-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03386-1", "uniprot_id": [ { "id": "GNDS_RAT", "url": "https://www.uniprot.org/uniprot/Q03386", "type": "external" } ], "mass": 98869.0, "length": 895, "protein_name": "Ral guanine nucleotide dissociation stimulator", "gene_name": "Ralgds", "organism": "Rat", "refseq_name": "ral guanine nucleotide dissociation stimulator isoform 1", "refseq_ac": [ { "id": "NP_062123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062123", "type": "external" } ], "gene_names_uniprotkb": "Ralgds", "gene_names_refseq": "Ralgds; Rgds", "protein_names_uniprotkb": "Ral guanine nucleotide dissociation stimulator; Ral guanine nucleotide exchange factor; RalGDS; RalGEF", "protein_names_refseq": "ral guanine nucleotide dissociation stimulator isoform 1; ral guanine nucleotide exchange factor; ralGEF", "tax_id": 10116, "disease": "", "pathway": " (rno:29622); (R-RNO-171007); (R-RNO-5673001)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "12642511;8094051;9253406", "class_list": "", "function": "Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex., [UniProtKB, UniProtKB, UniProtKB]; Ral GDP dissociation stimulator is involved in myocardial hypertrophy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0030695 GTPase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0007265 Ras protein signal transduction;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q03386-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38062-1", "uniprot_id": [ { "id": "MAP2_RAT", "url": "https://www.uniprot.org/uniprot/P38062", "type": "external" } ], "mass": 53052.0, "length": 478, "protein_name": "Methionine aminopeptidase 2", "gene_name": "Metap2", "organism": "Rat", "refseq_name": "methionine aminopeptidase 2", "refseq_ac": [ { "id": "NP_071984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071984", "type": "external" } ], "gene_names_uniprotkb": "Metap2; METAP2; Mnpep; P67eif2", "gene_names_refseq": "Amp2; Metap2; Mnpep; p67", "protein_names_uniprotkb": "Methionine aminopeptidase 2; 3.4.11.18; Initiation factor 2-associated 67 kDa glycoprotein; MAP 2; MetAP 2; Peptidase M; p67eIF2; p67", "protein_names_refseq": "MAP 2; initiation factor 2 associated 67 kDa protein; initiation factor 2-associated 67 kDa glycoprotein; metAP 2; methionine aminopeptidase 2; p67eIF2; peptidase M 2", "tax_id": 10116, "disease": "", "pathway": " (rno:64370); (R-RNO-2514859)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12731887;15178489;16857189;17446530;21033716;22673903;7644482;8496145;8647865;9705841", "class_list": "", "function": "Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)., [UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB]; Data suggest that methionine aminopeptidase 2 plays a role in the proliferation of fibroblasts and myofibroblasts in fibrotic lung diseases and may serve as a novel pharmacologic target in idiopathic pulmonary fibrosis., [RefSeq, PubMed]; Ectopic expression of rat p67/MetAP2 in transformed cells can inhibit the tumorigenic phenotype by inhibiting the activation and activity of ERK1/2 MAP kinases and, thus, that p67/MetAP2 has tumor suppression activity., [RefSeq, PubMed]; Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis., [UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016485 protein processing;GO:0006446 regulation of translational initiation;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P38062-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EB59-1", "uniprot_id": [ { "id": "MED23_RAT", "url": "https://www.uniprot.org/uniprot/Q5EB59", "type": "external" } ], "mass": 156232.0, "length": 1367, "protein_name": "Mediator of RNA polymerase II transcription subunit 23", "gene_name": "Med23", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Med23; Crsp3", "gene_names_refseq": "", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 23; CRSP complex subunit 3; Cofactor required for Sp1 transcriptional activation subunit 3; Mediator complex subunit 23", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 18 (Disease Ontology:DOID:0081190)", "pathway": " (rno:309565); (R-RNO-9841922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Also required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0006355 regulation of DNA-templated transcription;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5EB59-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2N4-1", "uniprot_id": [ { "id": "MKNK2_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2N4", "type": "external" } ], "mass": 51574.0, "length": 459, "protein_name": "MAP kinase-interacting serine/threonine-protein kinase 2", "gene_name": "Mknk2", "organism": "Rat", "refseq_name": "MAP kinase-interacting serine/threonine-protein kinase 2", "refseq_ac": [ { "id": "NP_001011985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011985", "type": "external" } ], "gene_names_uniprotkb": "Mknk2", "gene_names_refseq": "Mknk2", "protein_names_uniprotkb": "MAP kinase-interacting serine/threonine-protein kinase 2; 2.7.11.1; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2", "protein_names_refseq": "MAP kinase signal-integrating kinase 2; MAP kinase-interacting serine/threonine kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; MAPK signal-integrating kinase 2; mnk2", "tax_id": 10116, "disease": "", "pathway": " (rno:299618)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0016605 PML body;GO:0005829 cytosol", "go_biological_process": "GO:0006417 regulation of translation;GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0030097 hemopoiesis;GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2N4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q569C2-1", "uniprot_id": [ { "id": "LR2BP_RAT", "url": "https://www.uniprot.org/uniprot/Q569C2", "type": "external" } ], "mass": 39633.0, "length": 346, "protein_name": "LRP2-binding protein", "gene_name": "Lrp2bp", "organism": "Rat", "refseq_name": "LRP2-binding protein", "refseq_ac": [ { "id": "NP_001017443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017443", "type": "external" } ], "gene_names_uniprotkb": "Lrp2bp", "gene_names_refseq": "Lrp2bp; RGD1305896", "protein_names_uniprotkb": "LRP2-binding protein", "protein_names_refseq": "LRP2-binding protein; low density lipoprotein receptor-related protein 2 binding protein; megalin-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:290753)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as an adapter that regulates LRP2 function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q569C2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81799-1", "uniprot_id": [ { "id": "NAGK_RAT", "url": "https://www.uniprot.org/uniprot/P81799", "type": "external" } ], "mass": 37196.0, "length": 343, "protein_name": "N-acetyl-D-glucosamine kinase", "gene_name": "Nagk", "organism": "Rat", "refseq_name": "N-acetyl-D-glucosamine kinase", "refseq_ac": [ { "id": "NP_001032857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032857", "type": "external" } ], "gene_names_uniprotkb": "Nagk", "gene_names_refseq": "Nagk", "protein_names_uniprotkb": "N-acetyl-D-glucosamine kinase; 2.7.1.-; 2.7.1.59; 2.7.1.60; GlcNAc kinase; Muramyl dipeptide kinase; N-acetyl-D-mannosamine kinase; N-acetylglucosamine kinase", "protein_names_refseq": "N-acetyl-D-glucosamine kinase; N-acetyl-D-mannosamine kinase; glcNAc kinase; muramyl dipeptide kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:297393); (R-RNO-446210)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "17448495;22673903;24625575;25921606;26272270;26467288;9523722", "class_list": "", "function": "Analysis of oligomeric states of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by biophysical methods, [RefSeq, PubMed]; Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:9523722). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data shows associations between NAGK, speckle, paraspeckle and general transcription factor suggesting its regulatory roles in gene expression., [RefSeq, PubMed]; The interaction between NAGK and Dynlrb1 frequently occurs at dendritic branch points. Publication Status: Online-Only, [RefSeq, PubMed]; This work studied the role played by NAGK in axonal development., [RefSeq, PubMed]; Upregulation of dendritic complexity is a non-canonical function of NAGK., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32Q91", "ec_number_list": [ { "id": "2.7.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.60", "type": "external" }, { "id": "2.7.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0009384 N-acylmannosamine kinase activity;GO:0005524 ATP binding;GO:0045127 N-acetylglucosamine kinase activity;GO:0160047 muramyl dipeptide kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0006046 N-acetylglucosamine catabolic process;GO:0045087 innate immune response;GO:0042742 defense response to bacterium;GO:0006048 UDP-N-acetylglucosamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P81799-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98105-1", "uniprot_id": [ { "id": "LYAM2_RAT", "url": "https://www.uniprot.org/uniprot/P98105", "type": "external" } ], "mass": 60080.0, "length": 549, "protein_name": "E-selectin", "gene_name": "Sele", "organism": "Rat", "refseq_name": "E-selectin isoform 1 precursor", "refseq_ac": [ { "id": "NP_620234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620234", "type": "external" } ], "gene_names_uniprotkb": "Sele; Elam-1", "gene_names_refseq": "Sele", "protein_names_uniprotkb": "E-selectin; CD62 antigen-like family member E; ELAM-1; Endothelial leukocyte adhesion molecule 1; LECAM2; Leukocyte-endothelial cell adhesion molecule 2", "protein_names_refseq": "CD62 antigen-like family member E; E-selectin isoform 1 precursor; E-selectin; ELAM-1; LECAM2; endothelial leukocyte adhesion molecule 1; leukocyte-endothelial cell adhesion molecule 2; selectin, endothelial cell", "tax_id": 10116, "disease": "COVID-19 (Disease Ontology:DOID:0080600); aortic atherosclerosis (Disease Ontology:DOID:10230); brain ischemia (Disease Ontology:DOID:2316); IgA glomerulonephritis (Disease Ontology:DOID:2986); coronary artery disease (Disease Ontology:DOID:3393); cerebrovascular disease (Disease Ontology:DOID:6713); rheumatic myocarditis (Disease Ontology:DOID:8481); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:25544); (R-RNO-202733)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25182537;27033411", "class_list": "", "function": "Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Expression of E-selectin and CAMs was also modified in an age- and ischemia/reperfusion-dependent manner., [RefSeq, PubMed]; The e-selectin/biliverdin reductase pathway participates in the inhibitory process of hypoxia in pulmonary artery endothelial cell apoptosis which is mediated by the mitochondrial-dependent apoptosis pathway., [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0033691 sialic acid binding;GO:0043274 phospholipase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0045121 membrane raft;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0007155 cell adhesion;GO:0007159 leukocyte cell-cell adhesion;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P98105-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C8E4-1", "uniprot_id": [ { "id": "M3K7_RAT", "url": "https://www.uniprot.org/uniprot/P0C8E4", "type": "external" } ], "mass": 67200.0, "length": 606, "protein_name": "Mitogen-activated protein kinase kinase kinase 7", "gene_name": "Map3k7", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase kinase kinase 7", "refseq_ac": [ { "id": "NP_001101390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101390", "type": "external" } ], "gene_names_uniprotkb": "Map3k7", "gene_names_refseq": "Map3k7; Tak1", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 7; 2.7.11.25", "protein_names_refseq": "TGF-beta activated kinase 1; mitogen-activated protein kinase kinase kinase 7-like; mitogen-activated protein kinase kinase kinase 7", "tax_id": 10116, "disease": "frontometaphyseal dysplasia (Disease Ontology:DOID:0111785); frontometaphyseal dysplasia 2 (Disease Ontology:DOID:0111787); prostate cancer (Disease Ontology:DOID:10283); benign hypertensive renal disease (Disease Ontology:DOID:11520); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); arteriosclerosis (Disease Ontology:DOID:2349); coronary artery disease (Disease Ontology:DOID:3393); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:313121); (R-RNO-168638); (R-RNO-202424); (R-RNO-2871837); (R-RNO-4086398); (R-RNO-445989); (R-RNO-450302); (R-RNO-450321); (R-RNO-5357956); (R-RNO-5607764); (R-RNO-5689880); (R-RNO-9020702); (R-RNO-937042); (R-RNO-937072); (R-RNO-9645460); (R-RNO-975163)", "pathway_count": 16, "publication_count": 9, "publication_id_list": "22673903;26473505;28698801;35078016;35842555;36279673;36642184;37329446;38756773", "class_list": "", "function": "DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model., [RefSeq, PubMed]; Exogenous TIPE2 Inhibit TAK1 to Improve Inflammation and Neuropathic Pain Induced by Sciatic Nerve Injury Through Inactivating NF-kappaB and JNK., [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs); both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1). Independently of MAP2Ks and p38 MAPKs, acts as a key activator of NF-kappa-B by promoting activation of the I-kappa-B-kinase (IKK) core complex. Mechanistically, recruited to polyubiquitin chains of RIPK2 and IKBKG/NEMO via TAB2/MAP3K7IP2 and TAB3/MAP3K7IP3, and catalyzes phosphorylation and activation of IKBKB/IKKB component of the IKK complex, leading to NF-kappa-B activation. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity. Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis. Phosphorylates STING1 in response to cGAMP-activation, promoting association between STEEP1 and STING1 and STING1 translocation to COPII vesicles., [UniProtKB, UniProtKB, UniProtKB]; TAK1 Reduces Surgery-induced Overactivation of RIPK1 to Relieve Neuroinflammation and Cognitive Dysfunction in Aged Rats., [RefSeq, PubMed]; TAK1 inhibition mitigates intracerebral hemorrhage-induced brain injury through reduction of oxidative stress and neuronal pyroptosis via the NRF2 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0070498 interleukin-1-mediated signaling pathway;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P0C8E4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57113-1", "uniprot_id": [ { "id": "MAAI_RAT", "url": "https://www.uniprot.org/uniprot/P57113", "type": "external" } ], "mass": 23961.0, "length": 216, "protein_name": "Maleylacetoacetate isomerase", "gene_name": "Gstz1", "organism": "Rat", "refseq_name": "maleylacetoacetate isomerase", "refseq_ac": [ { "id": "NP_001102915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102915", "type": "external" } ], "gene_names_uniprotkb": "Gstz1", "gene_names_refseq": "Gstz1", "protein_names_uniprotkb": "Maleylacetoacetate isomerase; 2.5.1.18; 5.2.1.2; GSTZ1-1; Glutathione S-transferase zeta 1; MAAI", "protein_names_refseq": "GSTZ1-1; MAAI; glutathione S-transferase alpha 3; glutathione transferase zeta 1; maleylacetoacetate isomerase", "tax_id": 10116, "disease": "", "pathway": " (rno:681913); (R-RNO-156590); (R-RNO-204174); (R-RNO-8963684)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "20884751;22673903;29626439;9531472", "class_list": "", "function": "Probable bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Also has low glutathione peroxidase activity with t-butyl and cumene hydroperoxides (By similarity). Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The mitochondrion is a second site of dichloroacetate biotransformation in a reaction catalyzed by GSTZ1, an enzyme colocalized in the mitochondrial matrix and cytosol., [RefSeq, PubMed]; This study evaluated the metabolism of dichloroacetic acid in liver, hear, brain, and kidney via GSTZ1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0BNI1", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016034 maleylacetoacetate isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process;GO:0006749 glutathione metabolic process;GO:1990748 cellular detoxification", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P57113-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18088-1", "uniprot_id": [ { "id": "DCE1_RAT", "url": "https://www.uniprot.org/uniprot/P18088", "type": "external" } ], "mass": 66640.0, "length": 593, "protein_name": "Glutamate decarboxylase 1", "gene_name": "Gad1", "organism": "Rat", "refseq_name": "glutamate decarboxylase 1", "refseq_ac": [ { "id": "NP_058703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058703", "type": "external" } ], "gene_names_uniprotkb": "Gad1; Gad67", "gene_names_refseq": "Gad1; Gad67", "protein_names_uniprotkb": "Glutamate decarboxylase 1; 4.1.1.15; 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform", "protein_names_refseq": "67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 variant GAD67NT; glutamate decarboxylase 1; glutamic acid decarboxylase 1", "tax_id": 10116, "disease": "spastic cerebral palsy (Disease Ontology:DOID:0050669); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); autism spectrum disorder (Disease Ontology:DOID:0060041); hereditary spastic paraplegia 5A (Disease Ontology:DOID:0110810); congenital bile acid synthesis defect 3 (Disease Ontology:DOID:0111070); developmental and epileptic encephalopathy 89 (Disease Ontology:DOID:0112223); alcohol use disorder (Disease Ontology:DOID:1574); drug psychosis (Disease Ontology:DOID:1742); epilepsy (Disease Ontology:DOID:1826); anxiety disorder (Disease Ontology:DOID:2030); transient cerebral ischemia (Disease Ontology:DOID:224); morphine dependence (Disease Ontology:DOID:2560); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24379); (R-RNO-888568); (R-RNO-888590)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1924335;2170798;2299361;36113682;36587827;37586565;38194067", "class_list": "", "function": "Age-related changes in glutamic acid decarboxylase 1 gene expression in the medial prefrontal cortex and ventral hippocampus of fear-potentiated rats subjected to isolation stress., [RefSeq, PubMed]; Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Expression of GAD65/67 and VGLUT2 in Mediobasal Nuclei of Rat Hypothalamus during Aging., [RefSeq, PubMed]; Homotaurine ameliorates the core ASD symptomatology in VPA rats through GABAergic signaling: Role of GAD67., [RefSeq, PubMed]; Parvalbumin in the metabolic pathway of glutamate and gamma-aminobutyric acid: Influence on expression of GAD65 and GAD67., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.15", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004351 glutamate decarboxylase activity;GO:0016595 glutamate binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0090326 positive regulation of locomotion involved in locomotory behavior;GO:0035900 response to isolation stress;GO:0045471 response to ethanol;GO:0071456 cellular response to hypoxia;GO:0032570 response to progesterone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18088-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQR9-1", "uniprot_id": [ { "id": "MEMO1_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQR9", "type": "external" } ], "mass": 33679.0, "length": 297, "protein_name": "Protein MEMO1", "gene_name": "Memo1", "organism": "Rat", "refseq_name": "protein MEMO1", "refseq_ac": [ { "id": "NP_001025088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025088", "type": "external" } ], "gene_names_uniprotkb": "Memo1", "gene_names_refseq": "Memo1; RGD1309929", "protein_names_uniprotkb": "Protein MEMO1; Mediator of ErbB2-driven cell motility 1; Memo-1", "protein_names_refseq": "mediator of ErbB2-driven cell motility 1; memo-1; protein MEMO1; protein memo", "tax_id": 10116, "disease": "", "pathway": " (rno:298787); (R-RNO-6785631)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0032886 regulation of microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4QQR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97607-1", "uniprot_id": [ { "id": "JAG2_RAT", "url": "https://www.uniprot.org/uniprot/P97607", "type": "external" } ], "mass": 129705.0, "length": 1202, "protein_name": "Protein jagged-2", "gene_name": "Jag2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Jag2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein jagged-2; Jagged2", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive limb-girdle muscular dystrophy type 27 (Disease Ontology:DOID:0061133); autosomal dominant nonsyndromic deafness 71 (Disease Ontology:DOID:0080267); developmental and epileptic encephalopathy 81 (Disease Ontology:DOID:0112217); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (R-RNO-9013507)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8948600", "class_list": "", "function": "Putative Notch ligand involved in the mediation of Notch signaling., [UniProtKB, UniProtKB, UniProtKB]; Putative Notch ligand involved in the mediation of Notch signaling. May have a role in neurogenesis in the peripheral nervous system, limb development and in the adult brain., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005112 Notch binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0045061 thymic T cell selection;GO:0001701 in utero embryonic development;GO:0003016 respiratory system process;GO:0007219 Notch signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97607-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12847-1", "uniprot_id": [ { "id": "MYH3_RAT", "url": "https://www.uniprot.org/uniprot/P12847", "type": "external" } ], "mass": 223858.0, "length": 1940, "protein_name": "Myosin-3", "gene_name": "Myh3", "organism": "Rat", "refseq_name": "myosin-3", "refseq_ac": [ { "id": "NP_036736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036736", "type": "external" } ], "gene_names_uniprotkb": "Myh3", "gene_names_refseq": "Myh3; Myhse; RNMHCG", "protein_names_uniprotkb": "Myosin-3; Myosin heavy chain 3; Myosin heavy chain, fast skeletal muscle, embryonic", "protein_names_refseq": "myosin heavy chain, fast skeletal muscle, embryonic; myosin heavy polypeptide 3; myosin, heavy chain 3, skeletal muscle, embryonic; myosin, heavy polypeptide 3, skeletal muscle, embryonic; myosin-3", "tax_id": 10116, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A (Disease Ontology:DOID:0081321); contractures, pterygia, and spondylocarpotarsal fusion syndrome 1B (Disease Ontology:DOID:0081322); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B (Disease Ontology:DOID:0111599); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)", "pathway": " (rno:24583); (R-RNO-390522)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17289664;2981212;2999140;37245538;3783701", "class_list": "", "function": "METTL3 achieves lipopolysaccharide-induced myocardial injury via m[6]A-dependent stabilization of Myh3 mRNA., [RefSeq, PubMed]; Muscle contraction., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0030016 myofibril;GO:0043292 contractile muscle fiber;GO:0016459 myosin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006936 muscle contraction;GO:0046034 ATP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P12847-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5Q0T9-1", "uniprot_id": [ { "id": "METRN_RAT", "url": "https://www.uniprot.org/uniprot/Q5Q0T9", "type": "external" } ], "mass": 31353.0, "length": 291, "protein_name": "Meteorin", "gene_name": "Metrn", "organism": "Rat", "refseq_name": "meteorin precursor", "refseq_ac": [ { "id": "NP_001009962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009962", "type": "external" } ], "gene_names_uniprotkb": "Metrn; Hyrac", "gene_names_refseq": "Hyrac; Metrn; RGD1306222", "protein_names_uniprotkb": "Meteorin; Hypoxia/reoxygenation regulatory factor", "protein_names_refseq": "hypoxia/reoxygenation regulatory factor; meteorin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:287151)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19259827;20840868;22044868", "class_list": "", "function": "Cellular protection afforded by meteorin is associated with normalization of neurological performance on spontaneous forelimb placing and cylinder behavioral tests., [RefSeq, PubMed]; Data show that Meteorin is expressed in the central nervous system both during development and in adult mice., [RefSeq, PubMed]; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity)., [UniProtKB]; Metrn promotes migration of neuroblasts from subventricular zone explants of postnatal rats and stroke-subjected adult rats via a chemokinetic mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0050772 positive regulation of axonogenesis;GO:0010001 glial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5Q0T9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02346-1", "uniprot_id": [ { "id": "MYOD1_RAT", "url": "https://www.uniprot.org/uniprot/Q02346", "type": "external" } ], "mass": 34359.0, "length": 318, "protein_name": "Myoblast determination protein 1", "gene_name": "Myod1", "organism": "Rat", "refseq_name": "myoblast determination protein 1", "refseq_ac": [ { "id": "NP_788268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788268", "type": "external" } ], "gene_names_uniprotkb": "Myod1; Myod", "gene_names_refseq": "Myod1", "protein_names_uniprotkb": "Myoblast determination protein 1", "protein_names_refseq": "myoblast determination protein 1", "tax_id": 10116, "disease": "congenital myopathy 17 (Disease Ontology:DOID:0081349); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:337868); (R-RNO-525793)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1321778;25809587;26914683;31619581;9234731", "class_list": "", "function": "Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation., [UniProtKB, UniProtKB]; Long non-coding RNA MALAT1 promotes cardiac remodeling in hypertensive rats by inhibiting the transcription of MyoD., [RefSeq, PubMed]; Low-level laser therapy (LLLT) administered following muscle injury modulates the mRNA expression of MyoD and myogenin. Moreover, the both forms of LLLT administration were able to modulate the mRNA expression of IL-6 during the muscle repair process., [RefSeq, PubMed]; NMJ formation following reinnervation might prompt recovery of M-cadherin and MyoD mRNA expression to the quiescent level of SCs, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0007518 myoblast fate determination;GO:0014904 myotube cell development;GO:0043335 protein unfolding;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q02346-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1J2-1", "uniprot_id": [ { "id": "MBOA2_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1J2", "type": "external" } ], "mass": 59001.0, "length": 519, "protein_name": "Membrane-bound glycerophospholipid O-acyltransferase 2", "gene_name": "Mboat2", "organism": "Rat", "refseq_name": "membrane-bound glycerophospholipid O-acyltransferase 2", "refseq_ac": [ { "id": "NP_001101486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101486", "type": "external" } ], "gene_names_uniprotkb": "Mboat2; Oact2", "gene_names_refseq": "LPAAT; LPCAT; LPEAT; LPLAT 2; Mboat2; Oact2", "protein_names_uniprotkb": "Membrane-bound glycerophospholipid O-acyltransferase 2; 1-acylglycerophosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 2.3.1.-; 2.3.1.23; 2.3.1.51; 2.3.1.n7; LPAAT; LPCAT; LPEAT; LPLAT 2; Lyso-PA acyltransferase; Lyso-PC acyltransferase 4; Lyso-PC acyltransferase; Lyso-PE acyltransferase; Lysophosphatidic acid acyltransferase; Lysophosphatidylcholine acyltransferase 4; Lysophosphatidylcholine acyltransferase; Lysophosphatidylethanolamine acyltransferase; Lysophospholipid acyltransferase 2; Membrane-bound O-acyltransferase domain-containing protein 2; O-acyltransferase domain-containing protein 2", "protein_names_refseq": "1-acylglycerophosphate O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; O-acyltransferase (membrane bound) domain containing 2; lyso-PA acyltransferase; lyso-PC acyltransferase 4; lyso-PC acyltransferase; lyso-PE acyltransferase; lysophosphatidic acid acyltransferase; lysophosphatidylcholine acyltransferase 4; lysophosphatidylcholine acyltransferase; lysophosphatidylethanolamine acyltransferase; lysophospholipid acyltransferase 2; membrane bound O-acyltransferase domain containing 2; membrane-bound O-acyltransferase domain-containing protein 2; membrane-bound glycerophospholipid O-acyltransferase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:313997); (R-RNO-1482788); (R-RNO-1482839)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. May catalyze preferentially the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) and lysophosphatidic acid (LPA) and to a lesser extend lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS). Prefers oleoyl-CoA as the acyl donor (By similarity). May be involved in chondrocyte differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.15", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0016746 acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity;GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036152 phosphatidylethanolamine acyl-chain remodeling;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0032330 regulation of chondrocyte differentiation;GO:0008654 phospholipid biosynthetic process;GO:0036150 phosphatidylserine acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T1J2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85171-1", "uniprot_id": [ { "id": "MDGA1_RAT", "url": "https://www.uniprot.org/uniprot/P85171", "type": "external" } ], "mass": 105976.0, "length": 956, "protein_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1", "gene_name": "Mdga1", "organism": "Rat", "refseq_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor", "refseq_ac": [ { "id": "NP_001401873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401873", "type": "external" } ], "gene_names_uniprotkb": "Mdga1", "gene_names_refseq": "Mdga1", "protein_names_uniprotkb": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Ig6M", "protein_names_refseq": "MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor; MAM domain-containing glycosylphosphatidylinositol anchor protein 1; ig6M", "tax_id": 10116, "disease": "", "pathway": " (rno:309659); (R-RNO-163125)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15019943;23248271;23358245;37955815;38843836", "class_list": "", "function": "MDGA binding and suppression of synaptogenic activity was selective for neuroligin-2 and not neuroligin-1 excitatory synapse organizer., [RefSeq, PubMed]; MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development. Erratum:[Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2410442121. doi: 10.1073/pnas.2410442121. PMID: 38885391], [RefSeq, PubMed]; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2., [UniProtKB, PubMed, PubMed]; Required for radial migration of cortical neurons in the superficial layer of the neocortex. Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0099054 presynapse assembly;GO:0007399 nervous system development;GO:0001764 neuron migration;GO:0060134 prepulse inhibition", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P85171-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97594-1", "uniprot_id": [ { "id": "MCPT8_RAT", "url": "https://www.uniprot.org/uniprot/P97594", "type": "external" } ], "mass": 27463.0, "length": 248, "protein_name": "Mast cell protease 8", "gene_name": "Mcpt10; Mcpt8; Mcpt9", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mcpt10; Mcpt8; Mcpt9; LOC134481969; Mcpt10; Mcpt8l2; Mcpt8l3; Mcpt8; Mcpt9", "gene_names_refseq": "", "protein_names_uniprotkb": "Mast cell protease 8; 3.4.21.-; Mast cell protease VIII; rMCP-8; rMCP-VIII", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:29269); (rno:54269); (rno:54272)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8996238", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97594-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0S7-1", "uniprot_id": [ { "id": "H2AZ_RAT", "url": "https://www.uniprot.org/uniprot/P0C0S7", "type": "external" } ], "mass": 13553.0, "length": 128, "protein_name": "Histone H2A.Z", "gene_name": "H2az1-ps2; H2az1; H2az2l1; H2az2l2; H2az2l3; H2az2", "organism": "Rat", "refseq_name": "histone H2A.Z", "refseq_ac": [ { "id": "NP_073165", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073165", "type": "external" } ], "gene_names_uniprotkb": "H2az1-ps2; H2az1; H2az2l1; H2az2l2; H2az2l3; H2az2; H2afv; H2afz; H2az1-ps1; H2az2l1; H2az2l2; H2az2l3; H2az2; H2az; LOC689408; RGD1560813", "gene_names_refseq": "H2A.Z-1; H2A/z; H2afz; H2az1", "protein_names_uniprotkb": "Histone H2A.Z; H2A/z", "protein_names_refseq": "H2A histone family, member Z; histone H2A.Z", "tax_id": 10116, "disease": "", "pathway": " (rno:498894); (rno:58940); (rno:685069); (rno:685909); (rno:689408); (R-RNO-110330); (R-RNO-110331); (R-RNO-212300); (R-RNO-2299718); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559586); (R-RNO-427359); (R-RNO-427413); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-5625886); (R-RNO-606279); (R-RNO-68616); (R-RNO-73728); (R-RNO-73772); (R-RNO-8936459); (R-RNO-9018519); (R-RNO-9764725); (R-RNO-9841922); (R-RNO-9843940); (R-RNO-9843970); (R-RNO-9909649); (R-RNO-9940951); (R-RNO-9943411); (R-RNO-9943962); (R-RNO-9970672)", "pathway_count": 32, "publication_count": 5, "publication_id_list": "19343714;28856239;29871976;3344202;37175793", "class_list": "", "function": "H2A.Z occupancy preferentially promotes nucleosome turnover, and facilitates the recruitment of SMAD3 and MED1, thereby activating VSMC marker gene expression., [RefSeq, PubMed]; Immunohistochemical Pattern of Histone H2A Variant Expression in an Experimental Model of Ischemia-Reperfusion-Induced Acute Kidney Injury. Publication Status: Online-Only, [RefSeq, PubMed]; In dissociated rat cortical neurons, H2A.Z.1 and H2A.Z.2 regulate basal expression of largely nonoverlapping gene sets, including genes that code for several synaptic proteins. In response to neuronal activity, rapid transcription of our model gene Arc is impaired by depletion of H2A.Z.2, but not H2A.Z.1. This impairment is partially rescued by codepletion of the H2A.Z chaperone, ANP32E. Publication Status: Online-Only, [RefSeq, PubMed]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17317;Q5U5H6", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000791 euchromatin;GO:0000792 heterochromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071392 cellular response to estradiol stimulus;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C0S7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3SWS9-1", "uniprot_id": [ { "id": "JKIP1_RAT", "url": "https://www.uniprot.org/uniprot/Q3SWS9", "type": "external" } ], "mass": 73107.0, "length": 626, "protein_name": "Janus kinase and microtubule-interacting protein 1", "gene_name": "Jakmip1", "organism": "Rat", "refseq_name": "janus kinase and microtubule-interacting protein 1 isoform 5", "refseq_ac": [ { "id": "NP_001029066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029066", "type": "external" } ], "gene_names_uniprotkb": "Jakmip1; Marlin1", "gene_names_refseq": "Jakmip1; Marlin-1; Marlin1", "protein_names_uniprotkb": "Janus kinase and microtubule-interacting protein 1; Marlin-1; Multiple alpha helices and RNA-linker protein 1", "protein_names_refseq": "janus kinase and microtubule-interacting protein 1 isoform 5; multiple alpha helices and RNA-linker protein 1; multiple coiled-coil GABABR1-binding protein", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:305434)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14718537;17532644;17668444;19386132;22673903;22828129", "class_list": "", "function": "Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements., [UniProtKB, PubMed]; Marlin-1 functions to regulate the cellular levels of GABA(B) R2 subunits, which may have significant effects on the production of functional GABA(B) receptor heterodimers., [RefSeq, PubMed]; Marlin-1 is enriched in restricted areas of the brain including olfactory bulb, cerebral cortex, hippocampus and cerebellum; it is abundant in dendrites and axons of hippocampal neurons, associated with microtubules at the ultrastructural level. Publication Status: Online-Only, [RefSeq, PubMed]; Our findings demonstrate that Marlin-1 associates with a microtubule fraction and with GABA(B) receptors in testis suggesting that the set of protein interactions of Marlin-1 are conserved in different tissues., [RefSeq, PubMed]; RNA interference of Marlin-1 in vivo results in abnormal migration and abnormal morphology of newborn pyramidal neurons during the formation of the cortex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008017 microtubule binding;GO:0019900 kinase binding;GO:0019894 kinesin binding;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0005874 microtubule;GO:0016020 membrane;GO:0015630 microtubule cytoskeleton;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0015031 protein transport;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q3SWS9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJN1-1", "uniprot_id": [ { "id": "Q5BJN1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJN1", "type": "external" } ], "mass": 40442.0, "length": 365, "protein_name": "START domain-containing protein 10", "gene_name": "Stard10", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Stard10", "gene_names_refseq": "", "protein_names_uniprotkb": "START domain-containing protein 10; PCTP-like protein; StAR-related lipid transfer protein 10", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:293150); (R-RNO-1483191)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0046581 intercellular canaliculus;GO:0005902 microvillus", "go_biological_process": "GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0032782 bile acid secretion;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R4W4-1", "uniprot_id": [ { "id": "M0R4W4_RAT", "url": "https://www.uniprot.org/uniprot/M0R4W4", "type": "external" } ], "mass": 31224.0, "length": 276, "protein_name": "protein-serine/threonine phosphatase", "gene_name": "Ctdspl", "organism": "Rat", "refseq_name": "CTD small phosphatase-like protein isoform 1", "refseq_ac": [ { "id": "NP_001382669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382669", "type": "external" } ], "gene_names_uniprotkb": "Ctdspl", "gene_names_refseq": "Ctdspl", "protein_names_uniprotkb": "protein-serine/threonine phosphatase; 3.1.3.16", "protein_names_refseq": "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; CTD small phosphatase-like protein isoform 1; CTD small phosphatase-like protein", "tax_id": 10116, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R4W4-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQN7-1", "uniprot_id": [ { "id": "LZIC_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQN7", "type": "external" } ], "mass": 21394.0, "length": 190, "protein_name": "Protein LZIC", "gene_name": "Lzic", "organism": "Rat", "refseq_name": "protein LZIC", "refseq_ac": [ { "id": "NP_001013259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013259", "type": "external" } ], "gene_names_uniprotkb": "Lzic; Tmem274", "gene_names_refseq": "Lzic", "protein_names_uniprotkb": "Protein LZIC; Leucine zipper and CTNNBIP1 domain-containing protein; Leucine zipper and ICAT homologous domain-containing protein", "protein_names_refseq": "leucine zipper and CTNNBIP1 domain-containing protein; leucine zipper and ICAT homologous domain-containing protein; protein LZIC", "tax_id": 10116, "disease": "osteosarcoma (Disease Ontology:DOID:3347)", "pathway": " (rno:366507)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008013 beta-catenin binding", "go_cellular_component": "", "go_biological_process": "GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQN7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7Z8-1", "uniprot_id": [ { "id": "G3V7Z8_RAT", "url": "https://www.uniprot.org/uniprot/G3V7Z8", "type": "external" } ], "mass": 32311.0, "length": 302, "protein_name": "Polyadenylate-binding protein 2", "gene_name": "Pabpn1", "organism": "Rat", "refseq_name": "polyadenylate-binding protein 2", "refseq_ac": [ { "id": "NP_001128480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128480", "type": "external" } ], "gene_names_uniprotkb": "Pabpn1", "gene_names_refseq": "Pabpn1", "protein_names_uniprotkb": "Polyadenylate-binding protein 2; Nuclear poly(A)-binding protein 1; Poly(A)-binding protein II; Polyadenylate-binding nuclear protein 1", "protein_names_refseq": "polyadenylate-binding protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:116697); (R-RNO-73856); (R-RNO-77595); (R-RNO-9770562); (R-RNO-9930044)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "22673903;35894779", "class_list": "", "function": "Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0070063 RNA polymerase binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:1990904 ribonucleoprotein complex;GO:0042405 nuclear inclusion body;GO:0005634 nucleus", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006397 mRNA processing;GO:0000165 MAPK cascade;GO:0071222 cellular response to lipopolysaccharide;GO:1904247 positive regulation of polynucleotide adenylyltransferase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3V7Z8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32ZG1-1", "uniprot_id": [ { "id": "DFB33_RAT", "url": "https://www.uniprot.org/uniprot/Q32ZG1", "type": "external" } ], "mass": 7253.0, "length": 62, "protein_name": "Beta-defensin 33", "gene_name": "Defb33", "organism": "Rat", "refseq_name": "beta-defensin 33 precursor", "refseq_ac": [ { "id": "NP_001032612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032612", "type": "external" } ], "gene_names_uniprotkb": "Defb33", "gene_names_refseq": "Defb33", "protein_names_uniprotkb": "Beta-defensin 33; BD-33; Defensin, beta 33", "protein_names_refseq": "BD-33; beta-defensin 33 precursor; beta-defensin 33", "tax_id": 10116, "disease": "", "pathway": " (rno:641647)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16033865", "class_list": "", "function": "Has antibacterial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q32ZG1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01946-1", "uniprot_id": [ { "id": "HBA_RAT", "url": "https://www.uniprot.org/uniprot/P01946", "type": "external" } ], "mass": 15329.0, "length": 142, "protein_name": "Hemoglobin subunit alpha-1/2", "gene_name": "Hba-a1; Hba-a3; Hba1; Hbq1b", "organism": "Rat", "refseq_name": "hemoglobin alpha, adult chain 2", "refseq_ac": [ { "id": "NP_001007723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007723", "type": "external" } ], "gene_names_uniprotkb": "Hba-a1; Hba-a3; Hba1; Hbq1b; Hba-a1; Hba-a2; Hba2; Hbq1b", "gene_names_refseq": "Glnc2; Glnc3; Hba-a1; Hba-a2; Hba1; Hba2", "protein_names_uniprotkb": "Hemoglobin subunit alpha-1/2; Alpha-1/2-globin; Hemoglobin alpha-1/2 chain", "protein_names_refseq": "2-alpha globin; 2-alpha-1 globin; Alpha-1/2-globin; Hemoglobin alpha-1/2 chain; Hemoglobin subunit alpha-1/2; globin c2; globin c3; hemoglobin alpha 2 chain; hemoglobin alpha, adult chain 2; hemoglobin, alpha 2", "tax_id": 10116, "disease": "hemoglobin H disease (Disease Ontology:DOID:0110031); Heinz body anemia (Disease Ontology:DOID:0111363); familial erythrocytosis 7 (Disease Ontology:DOID:0111631); Alzheimer's disease (Disease Ontology:DOID:10652); alpha thalassemia (Disease Ontology:DOID:1099)", "pathway": " (rno:100361053); (rno:25632); (rno:287167); (rno:360504); (R-RNO-1237044); (R-RNO-1247673); (R-RNO-2168880); (R-RNO-9707564); (R-RNO-9707616)", "pathway_count": 9, "publication_count": 12, "publication_id_list": "10196478;1191258;12500972;18077343;242324;29393594;34502162;3619896;4676390;6098570;8226096;8334153", "class_list": "", "function": "Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1 (PubMed:18077343). Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling (PubMed:18077343)., [UniProtKB, PubMed]; Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P33583;Q63243;Q80XV2;Q91V15", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0001540 amyloid-beta binding;GO:0001664 G protein-coupled receptor binding;GO:0020037 heme binding;GO:0019825 oxygen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0045776 negative regulation of blood pressure;GO:0042542 response to hydrogen peroxide;GO:0032355 response to estradiol;GO:0042744 hydrogen peroxide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P01946-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0P2-1", "uniprot_id": [ { "id": "GCSH_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0P2", "type": "external" } ], "mass": 18485.0, "length": 170, "protein_name": "Glycine cleavage system H protein, mitochondrial", "gene_name": "Gcshl1; Gcsh", "organism": "Rat", "refseq_name": "glycine cleavage system H protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_598282", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598282", "type": "external" } ], "gene_names_uniprotkb": "Gcshl1; Gcsh; AABR07007134.1; Gcsh; RGD1563099", "gene_names_refseq": "Gcsh", "protein_names_uniprotkb": "Glycine cleavage system H protein, mitochondrial; Lipoic acid-containing protein", "protein_names_refseq": "glycine cleavage system H protein, mitochondrial precursor; glycine cleavage system H protein, mitochondrial; glycine cleavage system protein H (aminomethyl carrier); lipoic acid-containing protein", "tax_id": 10116, "disease": "multiple mitochondrial dysfunctions syndrome (Disease Ontology:DOID:0070330); amino acid metabolic disorder (Disease Ontology:DOID:9252); glycine encephalopathy (Disease Ontology:DOID:9268)", "pathway": " (rno:171133); (R-RNO-6783984); (R-RNO-9857492)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The H protein shuttles the methylamine group of glycine from the P protein to the T protein., [UniProtKB, UniProtKB]; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0004047 aminomethyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005960 glycine cleavage complex", "go_biological_process": "GO:0019464 glycine decarboxylation via glycine cleavage system", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0P2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02803-1", "uniprot_id": [ { "id": "MT1_RAT", "url": "https://www.uniprot.org/uniprot/P02803", "type": "external" } ], "mass": 6006.0, "length": 61, "protein_name": "Metallothionein-1", "gene_name": "Mt1a; Mt1", "organism": "Rat", "refseq_name": "metallothionein-1", "refseq_ac": [ { "id": "NP_620181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620181", "type": "external" } ], "gene_names_uniprotkb": "Mt1a; Mt1; Mt1a; Mt1", "gene_names_refseq": "Mt1a; Mt1; Mt", "protein_names_uniprotkb": "Metallothionein-1; MT-1; MT-I; Metallothionein-I", "protein_names_refseq": "MT-1; MT-I; metallothionein-1; metallothionein-I", "tax_id": 10116, "disease": "kidney failure (Disease Ontology:DOID:1074); transient cerebral ischemia (Disease Ontology:DOID:224); median neuropathy (Disease Ontology:DOID:571)", "pathway": " (rno:24567)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "27523482;27939232;28377323;28760087;2959527;3023830;32495853;6184083;6470004;6687866", "class_list": "", "function": "After passing middle age we observe a huge increase in MT3 transcripts in both cortical and hippocampal areas, while the MT1/2 mRNA content increases slightly, [RefSeq, PubMed]; Although,there is induction of metallothionein due to arsenic toxicity, the sequestration of arsenic(III) ions by metallothionein was not observed. Therefore, it can be concluded that the sequestration of arsenic by metallothionein in liver is not the mechanism for providing protection in case of acute arsenic toxicity unlike cadmium and other toxic heavy elements., [RefSeq, PubMed]; MTIM affects retinal ganglion cells through PI3K/AKT signaling pathway., [RefSeq, PubMed]; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TBI in rats resulted in lower levels of MT1 and MT2; replication of these findings is necessary as is evaluation of the consequences of lower receptor levels., [RefSeq, PubMed]; The increased hepatic MT protein in diabetic rats was not associated with the metal levels, but was associated with the oxidative damage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0010043 response to zinc ion;GO:0043524 negative regulation of neuron apoptotic process;GO:0046686 response to cadmium ion;GO:0007263 nitric oxide mediated signal transduction;GO:0071276 cellular response to cadmium ion", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P02803-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30904-1", "uniprot_id": [ { "id": "MIF_RAT", "url": "https://www.uniprot.org/uniprot/P30904", "type": "external" } ], "mass": 12477.0, "length": 115, "protein_name": "Macrophage migration inhibitory factor", "gene_name": "Mifl2; Mif", "organism": "Rat", "refseq_name": "macrophage migration inhibitory factor", "refseq_ac": [ { "id": "NP_112313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112313", "type": "external" } ], "gene_names_uniprotkb": "Mifl2; Mif; AC127887.1; LOC120102174; LOC679748; Mifl2", "gene_names_refseq": "Mif", "protein_names_uniprotkb": "Macrophage migration inhibitory factor; 5.3.2.1; 5.3.3.12; Glutathione-binding 13 kDa protein; L-dopachrome isomerase; L-dopachrome tautomerase; MIF; Phenylpyruvate tautomerase", "protein_names_refseq": "L-dopachrome isomerase; L-dopachrome tautomerase; glutathione-binding 13 kDa protein; macrophage migration inhibitory factor (glycosylation-inhibiting factor); macrophage migration inhibitory factor; phenylpyruvate tautomerase", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); alcohol-associated liver disease (Disease Ontology:DOID:0070658); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); hypertension (Disease Ontology:DOID:10763); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); allergic disease (Disease Ontology:DOID:1205); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); cystitis (Disease Ontology:DOID:1679); epilepsy (Disease Ontology:DOID:1826); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); hamartoma (Disease Ontology:DOID:3462); retinitis (Disease Ontology:DOID:3612); lung non-small cell carcinoma (Disease Ontology:DOID:3908); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); borna disease (Disease Ontology:DOID:5154); pneumonia (Disease Ontology:DOID:552); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); myocarditis (Disease Ontology:DOID:820); lung disease (Disease Ontology:DOID:850); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:679748); (rno:81683); (R-RNO-202733); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "1436109;21454685;33994866;34242901;35395782;37674165;38740166;7951062;8605628", "class_list": "", "function": "Exosomes from adipose-derived stem cells regulate M1/M2 macrophage phenotypic polarization to promote bone healing via miR-451a/MIF. Publication Status: Online-Only, [RefSeq, PubMed]; MIF inhibition attenuates intervertebral disc degeneration by reducing nucleus pulposus cell apoptosis and inflammation., [RefSeq, PubMed]; MIF-mediated NF-kappaB signaling pathway regulates the pathogenesis of polycystic ovary syndrome in rats., [RefSeq, PubMed]; Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation. Publication Status: Online-Only, [RefSeq, PubMed]; Macrophage migration inhibitory factor regulates joint capsule fibrosis by promoting TGF-beta1 production in fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0007283 spermatogenesis;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P30904-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK20-1", "uniprot_id": [ { "id": "JUPI2_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK20", "type": "external" } ], "mass": 20070.0, "length": 190, "protein_name": "Jupiter microtubule associated homolog 2", "gene_name": "Cramp1; Jpt2", "organism": "Rat", "refseq_name": "jupiter microtubule associated homolog 2", "refseq_ac": [ { "id": "NP_001013200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013200", "type": "external" } ], "gene_names_uniprotkb": "Cramp1; Jpt2; Cramp1l; Cramp1; Hn1l; Jpt2", "gene_names_refseq": "Hn1l; Jpt2; RGD1305117", "protein_names_uniprotkb": "Jupiter microtubule associated homolog 2; HN1-like protein; Hematological and neurological expressed 1-like protein", "protein_names_refseq": "HN1-like protein; hematological and neurological expressed 1-like protein; jupiter microtubule associated homolog 2", "tax_id": 10116, "disease": "", "pathway": " (rno:360492)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "33758062", "class_list": "", "function": "HN1L/JPT2: A signaling protein that connects NAADP generation to Ca(2+) microdomain formation. Publication Status: Online-Only, [RefSeq, PubMed]; Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release. Confers NAADP-sensitivity to the two pore channels (TPCs) complex (By similarity). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed:33758062)., [UniProtKB, PubMed, UniProtKB]; Transcription factor, which specifically drives expression of histone H1 genes. Binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x) together with NPAT and GON4L, positively regulating their transcription., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0035363 histone locus body", "go_biological_process": "GO:0050848 regulation of calcium-mediated signaling;GO:0075509 endocytosis involved in viral entry into host cell;GO:0045893 positive regulation of DNA-templated transcription;GO:0007389 pattern specification process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32362-1", "uniprot_id": [ { "id": "DCUP_RAT", "url": "https://www.uniprot.org/uniprot/P32362", "type": "external" } ], "mass": 40453.0, "length": 364, "protein_name": "Uroporphyrinogen decarboxylase", "gene_name": "Urod", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Urod", "gene_names_refseq": "", "protein_names_uniprotkb": "Uroporphyrinogen decarboxylase; 4.1.1.37; UPD; URO-D", "protein_names_refseq": "", "tax_id": 10116, "disease": "porphyria (Disease Ontology:DOID:13268); breast cancer (Disease Ontology:DOID:1612); porphyria cutanea tarda (Disease Ontology:DOID:3132); hepatoerythropoietic porphyria (Disease Ontology:DOID:5230)", "pathway": " (rno:29421); (R-RNO-189451)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29393594;3658690", "class_list": "", "function": "Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.37", "type": "external" } ], "go_molecular_function": "GO:0008198 ferrous iron binding;GO:0004853 uroporphyrinogen decarboxylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046502 uroporphyrinogen III metabolic process;GO:0001889 liver development;GO:0045471 response to ethanol;GO:0032355 response to estradiol;GO:0006779 porphyrin-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P32362-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04903-1", "uniprot_id": [ { "id": "GSTA2_RAT", "url": "https://www.uniprot.org/uniprot/P04903", "type": "external" } ], "mass": 25559.0, "length": 222, "protein_name": "Glutathione S-transferase alpha-2", "gene_name": "Gsta2; Gsta5", "organism": "Rat", "refseq_name": "glutathione S-transferase alpha-2", "refseq_ac": [ { "id": "NP_001010921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010921", "type": "external" } ], "gene_names_uniprotkb": "Gsta2; Gsta5; Gsta2; Gsta5", "gene_names_refseq": "Gsta2; Gsta5", "protein_names_uniprotkb": "Glutathione S-transferase alpha-2; 2.5.1.18; GST 1b-1b; GST A2-2; GST Ya2; Glutathione S-transferase Ya-2", "protein_names_refseq": "GHS transferase; GST 1b-1b; GST A2-2; GST Ya2; glutathione S-transferase Ya subunit; glutathione S-transferase Ya-2; glutathione S-transferase alpha-2; glutathione transferase YA subunit", "tax_id": 10116, "disease": "ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:494499); (R-RNO-156590); (R-RNO-9748787)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "2645828;3025841;3766257;6292839;6325423;6547043", "class_list": "", "function": "Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63715", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0035731 dinitrosyl-iron complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0009617 response to bacterium;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process;GO:0035634 response to stilbenoid", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P04903-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61295-1", "uniprot_id": [ { "id": "HAND2_RAT", "url": "https://www.uniprot.org/uniprot/P61295", "type": "external" } ], "mass": 23666.0, "length": 217, "protein_name": "Heart- and neural crest derivatives-expressed protein 2", "gene_name": "Hand2", "organism": "Rat", "refseq_name": "heart- and neural crest derivatives-expressed protein 2", "refseq_ac": [ { "id": "NP_073187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073187", "type": "external" } ], "gene_names_uniprotkb": "Hand2; Dhand", "gene_names_refseq": "Hand2", "protein_names_uniprotkb": "Heart- and neural crest derivatives-expressed protein 2; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND", "protein_names_refseq": "dHand protein; deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; heart and neural crest derivatives expressed transcript 2; heart- and neural crest derivatives-expressed protein 2-like; heart- and neural crest derivatives-expressed protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:64637)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21241805;23284944", "class_list": "", "function": "Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity)., [UniProtKB]; HAND2 protein was endothelial specific and showed higher expression in the regions exposed to low WSS with disturbed flow., [RefSeq, PubMed]; These data suggest that cytokines can inhibit norepinephrine transporter expression through downregulation of Hand2 or Gata3 in cultured sympathetic neurons, but axotomy in adult animals selectively suppresses Hand2 expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O95300;O95301;P97833", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0001967 suckling behavior;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61295-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97881-1", "uniprot_id": [ { "id": "MUC13_RAT", "url": "https://www.uniprot.org/uniprot/P97881", "type": "external" } ], "mass": 57652.0, "length": 547, "protein_name": "Mucin-13", "gene_name": "Muc13", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Muc13", "gene_names_refseq": "", "protein_names_uniprotkb": "Mucin-13; MUC-13", "protein_names_refseq": "", "tax_id": 10116, "disease": "ischemia (Disease Ontology:DOID:326)", "pathway": " (R-RNO-913709); (R-RNO-9696264); (R-RNO-9696270); (R-RNO-9696273); (R-RNO-977068)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0016324 apical plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0030277 maintenance of gastrointestinal epithelium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P97881-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35777-1", "uniprot_id": [ { "id": "MAGT1_RAT", "url": "https://www.uniprot.org/uniprot/O35777", "type": "external" } ], "mass": 37993.0, "length": 335, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1", "gene_name": "Magt1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Magt1; Iag2", "gene_names_refseq": "", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1; IAP; Implantation-associated protein; MagT1; Magnesium transporter protein 1; Oligosaccharyl transferase subunit MAGT1", "protein_names_refseq": "", "tax_id": 10116, "disease": "X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia (Disease Ontology:DOID:0080319); congenital disorder of glycosylation Icc (Disease Ontology:DOID:0111839); prostate cancer (Disease Ontology:DOID:10283); bacterial infectious disease (Disease Ontology:DOID:104); primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (rno:116967); (R-RNO-5223345); (R-RNO-6798695); (R-RNO-9931295)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accessory component of the STT3B-containing form of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Also has oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Could indirectly play a role in Mg(2+) transport in epithelial cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160227 oligosaccharyltransferase complex B", "go_biological_process": "GO:0015693 magnesium ion transport;GO:1903830 magnesium ion transmembrane transport;GO:0050890 cognition;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O35777-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7C6-1", "uniprot_id": [ { "id": "GUAA_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7C6", "type": "external" } ], "mass": 76757.0, "length": 693, "protein_name": "GMP synthase [glutamine-hydrolyzing]", "gene_name": "Gmps", "organism": "Rat", "refseq_name": "GMP synthase [glutamine-hydrolyzing]", "refseq_ac": [ { "id": "NP_001019925", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019925", "type": "external" } ], "gene_names_uniprotkb": "Gmps", "gene_names_refseq": "Gmps", "protein_names_uniprotkb": "GMP synthase [glutamine-hydrolyzing]; 6.3.5.2; GMP synthetase; Glutamine amidotransferase", "protein_names_refseq": "GMP synthase [glutamine-hydrolyzing]; GMP synthase; GMP synthetase; glutamine amidotransferase; guanine monophosphate synthase; guanine monophosphate synthetase", "tax_id": 10116, "disease": "acute myelomonocytic leukemia (Disease Ontology:DOID:0081082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:295088); (R-RNO-73817); (R-RNO-9748787)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22673903;3436958", "class_list": "", "function": "Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0003921 GMP synthase activity;GO:0003922 GMP synthase (glutamine-hydrolyzing) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009410 response to xenobiotic stimulus;GO:0006177 GMP biosynthetic process;GO:0032263 GMP salvage;GO:1901367 response to L-cysteine", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4V7C6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98106-1", "uniprot_id": [ { "id": "LYAM3_RAT", "url": "https://www.uniprot.org/uniprot/P98106", "type": "external" } ], "mass": 83517.0, "length": 768, "protein_name": "P-selectin", "gene_name": "Selp", "organism": "Rat", "refseq_name": "P-selectin precursor", "refseq_ac": [ { "id": "NP_037246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037246", "type": "external" } ], "gene_names_uniprotkb": "Selp", "gene_names_refseq": "PSELECT; Selp", "protein_names_uniprotkb": "P-selectin; CD62 antigen-like family member P; GMP-140; Granule membrane protein 140; LECAM3; Leukocyte-endothelial cell adhesion molecule 3; PADGEM; Platelet activation dependent granule-external membrane protein", "protein_names_refseq": "CD62 antigen-like family member P; GMP-140; LECAM3; P-selectin precursor; P-selectin; PADGEM; granule membrane protein 140; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein; selectin, platelet", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); brain small vessel disease (Disease Ontology:DOID:0112313); Alzheimer's disease (Disease Ontology:DOID:10652); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); Sjogren's syndrome (Disease Ontology:DOID:12894); Kawasaki disease (Disease Ontology:DOID:13378); hereditary angioedema (Disease Ontology:DOID:14735); atherosclerosis (Disease Ontology:DOID:1936); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ulcerative colitis (Disease Ontology:DOID:8577); intermediate coronary syndrome (Disease Ontology:DOID:8805); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25651); (R-RNO-114608); (R-RNO-202733)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22575043;29378361;7520013", "class_list": "", "function": "Aortic cyclooxygenase-2 and P-selectin were significantly down-regulated in plant sterols and plant sterols + tripeptides groups., [RefSeq, PubMed]; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; P-selectin may indicate thrombotic risk assessment in atrial fibrillation, [RefSeq, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 10, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane;GO:0031092 platelet alpha granule membrane", "go_biological_process": "GO:0033623 regulation of integrin activation;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006954 inflammatory response;GO:0032496 response to lipopolysaccharide;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P98106-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1HCL7-1", "uniprot_id": [ { "id": "NADK2_RAT", "url": "https://www.uniprot.org/uniprot/Q1HCL7", "type": "external" } ], "mass": 48116.0, "length": 425, "protein_name": "NAD kinase 2, mitochondrial", "gene_name": "Nadk2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nadk2; Mnadk; Nadkd1", "gene_names_refseq": "", "protein_names_uniprotkb": "NAD kinase 2, mitochondrial; 2.7.1.23; Mitochondrial NAD kinase; NAD kinase domain-containing protein 1, mitochondrial", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:365699); (R-RNO-196807); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3B8P3", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0003951 NAD+ kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006741 NADP+ biosynthetic process;GO:0019674 NAD+ metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1HCL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29410-1", "uniprot_id": [ { "id": "KAD2_RAT", "url": "https://www.uniprot.org/uniprot/P29410", "type": "external" } ], "mass": 26379.0, "length": 239, "protein_name": "Adenylate kinase 2, mitochondrial", "gene_name": "Ak2", "organism": "Rat", "refseq_name": "adenylate kinase 2, mitochondrial isoform b", "refseq_ac": [ { "id": "NP_001029139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029139", "type": "external" } ], "gene_names_uniprotkb": "Ak2; AK2", "gene_names_refseq": "Ak2", "protein_names_uniprotkb": "Adenylate kinase 2, mitochondrial; 2.7.4.3; AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; Adenylate monophosphate kinase", "protein_names_refseq": "AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; adenylate kinase 2, mitochondrial isoform b; adenylate kinase 2, mitochondrial; adenylate monophosphate kinase", "tax_id": 10116, "disease": "reticular dysgenesis (Disease Ontology:DOID:0060020); neuronal ceroid lipofuscinosis 6A (Disease Ontology:DOID:0110729); neuronal ceroid lipofuscinosis 6B (Disease Ontology:DOID:0110730); neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (rno:24184); (R-RNO-499943)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22246993;8468325", "class_list": "", "function": "AK2 participates in the pathophysiological process of temporal lobe epilepsy., [RefSeq, PubMed]; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7C6", "ec_number_list": [ { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0097226 sperm mitochondrial sheath;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0036126 sperm flagellum", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046060 dATP metabolic process;GO:0001889 liver development;GO:0097066 response to thyroid hormone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P29410-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18266-1", "uniprot_id": [ { "id": "GSK3B_RAT", "url": "https://www.uniprot.org/uniprot/P18266", "type": "external" } ], "mass": 46742.0, "length": 420, "protein_name": "Glycogen synthase kinase-3 beta", "gene_name": "Gsk3b", "organism": "Rat", "refseq_name": "glycogen synthase kinase-3 beta", "refseq_ac": [ { "id": "NP_114469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114469", "type": "external" } ], "gene_names_uniprotkb": "Gsk3b", "gene_names_refseq": "Gsk3b", "protein_names_uniprotkb": "Glycogen synthase kinase-3 beta; 2.7.11.1; 2.7.11.26; FA; Factor A; GSK-3 beta; Serine/threonine-protein kinase GSK3B", "protein_names_refseq": "FA; GSK-3 beta; factor A; glycogen synthase kinase-3 beta; serine/threonine-protein kinase GSK3B", "tax_id": 10116, "disease": "diabetic encephalopathy (Disease Ontology:DOID:0050850); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); endometrial carcinoma (Disease Ontology:DOID:2871); substance-related disorder (Disease Ontology:DOID:303); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); vascular dementia (Disease Ontology:DOID:8725); degenerative disc disease (Disease Ontology:DOID:90); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (rno:84027); (R-RNO-195253); (R-RNO-196299); (R-RNO-3371453); (R-RNO-399956); (R-RNO-4641262); (R-RNO-5250924); (R-RNO-5610785); (R-RNO-69601); (R-RNO-9762114); (R-RNO-9856649); (R-RNO-9929356)", "pathway_count": 12, "publication_count": 141, "publication_id_list": "10910956;10995469;11094086;11533051;12421827;12526086;12551719;12710887;15073173;15741240;15788447;15877933;15950778;16041621;16051512;16181430;16191209;16478782;16538228;16557150;16611852;16802321;16810687;16815997;16902054;16934435;16996218;17242403;17427960;17570255;17623045;17686886;17996850;18089761;18323734;18424437;18434357;18485099;18660440;18840784;18983912;19033378;19218353;19318234;19652884;19875195;19887077;20154265;20180783;20308788;20362550;20398714;20433952;20549454;21265094;21420928;21457712;21643720;2164470;21945291;22212922;22643085;22673903;22922600;22960175;22975711;23088308;23266915;23302675;23321003;23603260;23701903;23860320;23943518;24211784;24248537;24349798;24583037;24722055;24950409;25234320;25424428;25476250;25535091;25724082;25938237;26131182;26144579;26218875;26300412;26305322;26352537;26386043;26504753;26899575;26918336;27012722;27034732;27107885;27208492;27235578;27768739;27866373;28185129;28197192;28265857;28315454;28446231;28468966;28821999;28868045;28957873;28961505;28964909;29043099;29197866;29298655;29346712;29555592;29656013;30263603;30457911;30868494;31046517;31197456;31201872;31316348;32783850;32823945;33519375;34948265;37714275;37863169;38227464;38372092;38843836;38950736;7686508;8250835;8382613;9482734", "class_list": "", "function": "A novel lncRNA TCONS_00071187 upregulated by activated GSK3beta promotes high glucose-induced mesangial cell proliferation in the diabetic nephropathy. Publication Status: Online-Only, [RefSeq, PubMed]; Cognitive-exercise dual-task intervention ameliorates cognitive decline in natural aging rats via inhibiting the promotion of LncRNA NEAT1/miR-124-3p on caveolin-1-PI3K/Akt/GSK3beta Pathway., [RefSeq, PubMed]; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates (PubMed:9482734). In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis (By similarity). May also mediate the development of insulin resistance by regulating activation of transcription factors (By similarity). Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase (By similarity). In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes (PubMed:9482734). Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF (TNF/TNFA) (By similarity). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes (PubMed:17242403). Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation (By similarity). Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth (By similarity). Phosphorylates MARK2, leading to inhibition of its activity (PubMed:18424437). Phosphorylates SIK1 at 'Thr-182', leading to sustainment of its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates FBXL2 at 'Thr-404' and primes it for ubiquitination by the SCF(FBXO3) complex and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (By similarity). Regulates the circadian rhythmicity of hippocampal long-term potentiation and BMAL1 and PER2 expression (By similarity). Acts as a regulator of autophagy by mediating phosphorylation of KAT5/TIP60 under starvation conditions, activating KAT5/TIP60 acetyltransferase activity and promoting acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer. Negatively regulates extrinsic apoptotic signaling pathway via death domain receptors. Promotes the formation of an anti-apoptotic complex, made of DDX3X, BRIC2 and GSK3B, at death receptors, including TNFRSF10B. The anti-apoptotic function is most effective with weak apoptotic signals and can be overcome by stronger stimulation (By similarity). Phosphorylates E2F1, promoting the interaction between E2F1 and USP11, stabilizing E2F1 and promoting its activity (By similarity). Phosphorylates mTORC2 complex component RICTOR at 'Ser-1235' in response to endoplasmic stress, inhibiting mTORC2 (By similarity). Acts as a negative regulator of smoothened signaling by mediating phosphorylation of GLI2 and GLI3 in absence of smoothened, promoting their processing by the SCF(BTRC) complex (By similarity). Phosphorylates FXR1, promoting FXR1 ubiquitination by the SCF(FBXO4) complex and FXR1 degradation by the proteasome (By similarity). Phosphorylates interleukin-22 receptor subunit IL22RA1, preventing its proteasomal degradation (By similarity). Phosphorylates and inhibits the CTP synthase and protein-asparagine deamidase activities of CTPS1 (By similarity). Phosphorylates DSP at multiple sequential serine residues in the C-terminus tail, promoting its recruitment to developing desmosome cell-cell junctions (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3beta at Thr252 by in Vitro Studies., [RefSeq, PubMed]; Hypoxia ischemia results in blood brain barrier damage via AKT/GSK-3beta/CREB pathway in neonatal rats., [RefSeq, PubMed]; The SIRT3/GSK-3beta/GLUT4 axis might be involved in maternal hypoxia-induced skeletal muscle insulin resistance in old male rat offspring., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0002020 protease binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005178 integrin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0050770 regulation of axonogenesis;GO:0014043 negative regulation of neuron maturation;GO:0035733 hepatic stellate cell activation;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 14.4, "record_id": "P18266-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50575-1", "uniprot_id": [ { "id": "DLX5_RAT", "url": "https://www.uniprot.org/uniprot/P50575", "type": "external" } ], "mass": 31426.0, "length": 289, "protein_name": "Homeobox protein DLX-5", "gene_name": "Dlx5", "organism": "Rat", "refseq_name": "homeobox protein DLX-5", "refseq_ac": [ { "id": "NP_037075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037075", "type": "external" } ], "gene_names_uniprotkb": "Dlx5", "gene_names_refseq": "Dlx5; RDLX", "protein_names_uniprotkb": "Homeobox protein DLX-5; Homeobox protein DLX-3; RDLX", "protein_names_refseq": "DLX-3; homeobox protein DLX-3; homeobox protein DLX-5", "tax_id": 10116, "disease": "split hand-foot malformation 1 (Disease Ontology:DOID:0090021); split hand-foot malformation 1 with sensorineural hearing loss (Disease Ontology:DOID:0090024)", "pathway": " (rno:25431)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "21503878;24042587;29901112;7913069;7915995", "class_list": "", "function": "OA transcription is differentially regulated by Dlx3, Dlx5, and Msx2 during osteoblast differentiation., [RefSeq, PubMed]; Results demonstrate that overexpression of Runx2, Dlx5 or c-Src stimulates BSP transcription, and suggest that Runx2, Dlx5 and c-Src might be crucial transcriptional regulators of mineralization and bone formation, [RefSeq, PubMed]; These results suggest that miR3395p negatively regulated loureirin Ainduced HFSC differentiation by targeting DLX5, resulting in Wnt/betacatenin signaling pathway inhibition., [RefSeq, PubMed]; Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007409 axonogenesis;GO:0008283 cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50575-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIG6-1", "uniprot_id": [ { "id": "GALK2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIG6", "type": "external" } ], "mass": 50198.0, "length": 458, "protein_name": "N-acetylgalactosamine kinase", "gene_name": "Galk2", "organism": "Rat", "refseq_name": "N-acetylgalactosamine kinase isoform 1", "refseq_ac": [ { "id": "NP_001013941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013941", "type": "external" } ], "gene_names_uniprotkb": "Galk2", "gene_names_refseq": "Galk2", "protein_names_uniprotkb": "N-acetylgalactosamine kinase; 2.7.1.157; GalNAc kinase; Galactokinase 2", "protein_names_refseq": "N-acetylgalactosamine kinase isoform 1; N-acetylgalactosamine kinase; galNAc kinase", "tax_id": 10116, "disease": "", "pathway": " (rno:296117)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts on GalNAc (By similarity). Also acts as a galactokinase when galactose is present at high concentrations (By similarity)., [UniProtKB, UniProtKB]; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.157", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.157", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004335 galactokinase activity;GO:0033858 N-acetylgalactosamine kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIG6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30710-1", "uniprot_id": [ { "id": "GPX5_RAT", "url": "https://www.uniprot.org/uniprot/P30710", "type": "external" } ], "mass": 25385.0, "length": 221, "protein_name": "Epididymal secretory glutathione peroxidase", "gene_name": "Gpx5", "organism": "Rat", "refseq_name": "epididymal secretory glutathione peroxidase precursor", "refseq_ac": [ { "id": "NP_001099208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099208", "type": "external" } ], "gene_names_uniprotkb": "Gpx5", "gene_names_refseq": "Gpx5", "protein_names_uniprotkb": "Epididymal secretory glutathione peroxidase; 1.11.1.9; EGLP; Epididymis-specific glutathione peroxidase-like protein; GPx-5; GSHPx-5; Glutathione peroxidase 5", "protein_names_refseq": "EGLP; GPx-5; GSHPx-5; epididymal secretory glutathione peroxidase precursor; epididymal secretory glutathione peroxidase; epididymis-specific glutathione peroxidase-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:113919); (R-RNO-3299685)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1386734;23696541;27025721;37761814", "class_list": "", "function": "Data (from studies with recombinant GPX5) suggest that GPX5 is secreted by epididymis via exocytosis/epididymosomes; then GPX5 is able to associate with (or transfer to) plasma membrane of sperm where it may protect sperm against oxidative damage., [RefSeq, PubMed]; Diabetic testes showed decreased Nrf2, HO-1, SOD1, PCNA, and Bcl-2 expressions whereas increased COX-2, NF-kappaB, MT, IL-6, and p-ERK levels. SOD1 and GPX5 were decreased in the epididymis of diabetic rat, whereas Zn supplementation attenuated these changes., [RefSeq, PubMed]; Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns. Publication Status: Online-Only, [RefSeq, PubMed]; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" } ], "go_molecular_function": "GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0097524 sperm plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P30710-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50617-1", "uniprot_id": [ { "id": "DEND_RAT", "url": "https://www.uniprot.org/uniprot/P50617", "type": "external" } ], "mass": 76004.0, "length": 707, "protein_name": "Dendrin", "gene_name": "Ddn", "organism": "Rat", "refseq_name": "dendrin", "refseq_ac": [ { "id": "NP_112255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112255", "type": "external" } ], "gene_names_uniprotkb": "Ddn; Den", "gene_names_refseq": "Ddn; Den", "protein_names_uniprotkb": "Dendrin", "protein_names_refseq": "dendrin", "tax_id": 10116, "disease": "", "pathway": " (rno:25113)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "16464232;16751601;17537921;19046379;8915891;9073398", "class_list": "", "function": "As Dendrin is an important component of cytoskeletal modifications at the synapse, these results suggest that nicotine influences unique plasticity-related changes in the adolescent forebrain that differ from the adult., [RefSeq, PubMed]; Postsynaptic recruitment of Dendrin depends on both local protein synthesis and association with MAGI/S-SCAM. Its nuclear localization capacity functions in retrograde signaling from the synapse to the nucleus., [RefSeq, PubMed]; Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97543", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P50617-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK57-1", "uniprot_id": [ { "id": "HAUS8_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK57", "type": "external" } ], "mass": 42332.0, "length": 385, "protein_name": "HAUS augmin-like complex subunit 8", "gene_name": "Haus8", "organism": "Rat", "refseq_name": "HAUS augmin-like complex subunit 8", "refseq_ac": [ { "id": "NP_001020142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020142", "type": "external" } ], "gene_names_uniprotkb": "Haus8; Hice1; Ny-sar-48", "gene_names_refseq": "Haus8; Ny-sar-48; RGD1311565", "protein_names_uniprotkb": "HAUS augmin-like complex subunit 8; HEC1/NDC80-interacting centrosome-associated protein 1; Sarcoma antigen NY-SAR-48 homolog", "protein_names_refseq": "HAUS augmin-like complex subunit 8; HEC1/NDC80-interacting centrosome-associated protein 1; sarcoma antigen NY-SAR-48 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:290626); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-8854518)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0070652 HAUS complex;GO:1990498 mitotic spindle microtubule", "go_biological_process": "GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q535K8-1", "uniprot_id": [ { "id": "GON4L_RAT", "url": "https://www.uniprot.org/uniprot/Q535K8", "type": "external" } ], "mass": 247903.0, "length": 2256, "protein_name": "GON-4-like protein", "gene_name": "Gon4l", "organism": "Rat", "refseq_name": "GON-4-like protein", "refseq_ac": [ { "id": "NP_001019968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019968", "type": "external" } ], "gene_names_uniprotkb": "Gon4l; Gon4", "gene_names_refseq": "Dingo; Gon4l; Yarp", "protein_names_uniprotkb": "GON-4-like protein; GON-4 homolog; Protein GON4", "protein_names_refseq": "GON-4 homolog; GON-4-like protein; YY1AP-related protein1", "tax_id": 10116, "disease": "salivary gland cancer (Disease Ontology:DOID:8850)", "pathway": " (rno:499653)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17285227;22673903", "class_list": "", "function": "Acts as a key transcription regulator of histones. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with GON4L and MIZF. Together with CRAMP1, binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x), driving their transcription (By similarity). Also acts as a transcription corepressor, as part of a complex with YY1, SIN3A and HDAC1. Required for B-cell lymphopoiesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Suggest that YARP functions at a late stage of neurogenesis during perinatal development of the rat brain, as well as in mature neurons., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q535K7", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030183 B cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q535K8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29826-1", "uniprot_id": [ { "id": "HB2B_RAT", "url": "https://www.uniprot.org/uniprot/P29826", "type": "external" } ], "mass": 29935.0, "length": 263, "protein_name": "Rano class II histocompatibility antigen, B-1 beta chain", "gene_name": "RT1-Bb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RT1-Bb", "gene_names_refseq": "", "protein_names_uniprotkb": "Rano class II histocompatibility antigen, B-1 beta chain; RT1 class II histocompatibility antigen, B-1 beta chain; RT1.B-beta(1)", "protein_names_refseq": "", "tax_id": 10116, "disease": "autoimmune pancreatitis (Disease Ontology:DOID:0040091); chikungunya (Disease Ontology:DOID:0050012); autoimmune polyendocrine syndrome type 2 (Disease Ontology:DOID:0050168); erythema multiforme (Disease Ontology:DOID:0050185); Stevens-Johnson syndrome (Disease Ontology:DOID:0050426); marginal zone lymphoma (Disease Ontology:DOID:0050748); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); rheumatic heart disease (Disease Ontology:DOID:0050827); cervical dystonia (Disease Ontology:DOID:0050840); stroke (Disease Ontology:DOID:0051061); immunoglobulin alpha deficiency (Disease Ontology:DOID:0060025); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); latex allergy (Disease Ontology:DOID:0060532); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); pemphigus vulgaris (Disease Ontology:DOID:0060851); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); osteomyelitis (Disease Ontology:DOID:1019); pneumoconiosis (Disease Ontology:DOID:10316); silicosis (Disease Ontology:DOID:10325); bacterial infectious disease (Disease Ontology:DOID:104); pre-eclampsia (Disease Ontology:DOID:10591); celiac disease (Disease Ontology:DOID:10608); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); sickle cell anemia (Disease Ontology:DOID:10923); common wart (Disease Ontology:DOID:11165); sarcoidosis (Disease Ontology:DOID:11335); rhinoscleroma (Disease Ontology:DOID:11336); pneumocystosis (Disease Ontology:DOID:11339); cicatricial pemphigoid (Disease Ontology:DOID:11656); degenerative myopia (Disease Ontology:DOID:11829); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); allergic disease (Disease Ontology:DOID:1205); optic neuritis (Disease Ontology:DOID:1210); alveolar echinococcosis (Disease Ontology:DOID:12148); common variable immunodeficiency (Disease Ontology:DOID:12177); beta thalassemia (Disease Ontology:DOID:12241); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); aplastic anemia (Disease Ontology:DOID:12449); vulva cancer (Disease Ontology:DOID:1245); choreatic disease (Disease Ontology:DOID:12859); Sjogren's syndrome (Disease Ontology:DOID:12894); dilated cardiomyopathy (Disease Ontology:DOID:12930); agranulocytosis (Disease Ontology:DOID:12987); uveitis (Disease Ontology:DOID:13141); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); Behcet's disease (Disease Ontology:DOID:13241); typhoid fever (Disease Ontology:DOID:13258); pure red-cell aplasia (Disease Ontology:DOID:1340); Addison's disease (Disease Ontology:DOID:13774); autoimmune polyendocrine syndrome (Disease Ontology:DOID:14040); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); hypothyroidism (Disease Ontology:DOID:1459); cystic echinococcosis (Disease Ontology:DOID:1495); rheumatic fever (Disease Ontology:DOID:1586); glaucoma (Disease Ontology:DOID:1686); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); dental caries (Disease Ontology:DOID:216); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); IgA glomerulonephritis (Disease Ontology:DOID:2986); antiphospholipid syndrome (Disease Ontology:DOID:2988); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); tuberculosis (Disease Ontology:DOID:399); multidrug-resistant tuberculosis (Disease Ontology:DOID:401); autoimmune disease (Disease Ontology:DOID:417); cervical cancer (Disease Ontology:DOID:4362); myasthenia gravis (Disease Ontology:DOID:437); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myositis (Disease Ontology:DOID:633); acute disseminated encephalomyelitis (Disease Ontology:DOID:639); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); stomach disease (Disease Ontology:DOID:76); hyperthyroidism (Disease Ontology:DOID:7998); myocarditis (Disease Ontology:DOID:820); arthritis (Disease Ontology:DOID:848); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); mycosis fungoides (Disease Ontology:DOID:8691); Crohn's disease (Disease Ontology:DOID:8778); neuromyelitis optica (Disease Ontology:DOID:8869); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); atrophic gastritis (Disease Ontology:DOID:8929); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); achalasia (Disease Ontology:DOID:9164); pemphigus (Disease Ontology:DOID:9182); colorectal cancer (Disease Ontology:DOID:9256); iridocyclitis (Disease Ontology:DOID:9383); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (R-RNO-202424); (R-RNO-202427); (R-RNO-202430); (R-RNO-202433); (R-RNO-2132295); (R-RNO-389948)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "1859846;29393594", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 105, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0006955 immune response;GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0042130 negative regulation of T cell proliferation;GO:0050852 T cell receptor signaling pathway;GO:0002503 peptide antigen assembly with MHC class II protein complex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P29826-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKG2-1", "uniprot_id": [ { "id": "HCFC2_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKG2", "type": "external" } ], "mass": 79149.0, "length": 723, "protein_name": "Host cell factor 2", "gene_name": "Hcfc2", "organism": "Rat", "refseq_name": "host cell factor 2", "refseq_ac": [ { "id": "NP_001008358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008358", "type": "external" } ], "gene_names_uniprotkb": "Hcfc2", "gene_names_refseq": "Hcfc2", "protein_names_uniprotkb": "Host cell factor 2; C2 factor; HCF-2", "protein_names_refseq": "C2 factor; HCF-2; host cell factor 2", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:314704); (R-RNO-9772755)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RKG2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08730-1", "uniprot_id": [ { "id": "GLYG_RAT", "url": "https://www.uniprot.org/uniprot/O08730", "type": "external" } ], "mass": 37378.0, "length": 333, "protein_name": "Glycogenin-1", "gene_name": "Gyg1", "organism": "Rat", "refseq_name": "glycogenin-1", "refseq_ac": [ { "id": "NP_112305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112305", "type": "external" } ], "gene_names_uniprotkb": "Gyg1; Gyg", "gene_names_refseq": "Gyg1; Gyg", "protein_names_uniprotkb": "Glycogenin-1; 2.4.1.186; GN-1; GN1", "protein_names_refseq": "GN-1; GN1; glycogenin-1", "tax_id": 10116, "disease": "glycogen storage disease XV (Disease Ontology:DOID:0050579); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (rno:81675); (R-RNO-3322077); (R-RNO-6798695); (R-RNO-70221)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10391131;29393594", "class_list": "glycogene;glycosyltransferase", "function": "Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6IHC8", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.4.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.18", "type": "external" }, { "id": "2.4.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.11", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0008466 glycogenin glucosyltransferase activity;GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1902494 catalytic complex", "go_biological_process": "GO:0005978 glycogen biosynthetic process;GO:0160249 glycogen biosynthetic process via UDP-glucose", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08730-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000001001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIE9-1", "uniprot_id": [ { "id": "MED20_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIE9", "type": "external" } ], "mass": 23180.0, "length": 212, "protein_name": "Mediator of RNA polymerase II transcription subunit 20", "gene_name": "Med20", "organism": "Rat", "refseq_name": "mediator of RNA polymerase II transcription subunit 20 isoform 1", "refseq_ac": [ { "id": "NP_001013196", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013196", "type": "external" } ], "gene_names_uniprotkb": "Med20; MED20; Trfp", "gene_names_refseq": "Med20; Trfp; Usp49", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 20; Mediator complex subunit 20; TRF-proximal protein homolog", "protein_names_refseq": "Trf (TATA binding protein-related factor)-proximal protein homolog; Trf-proximal protein homolog-like; mediator of RNA polymerase II transcription subunit 20 isoform 1; mediator of RNA polymerase II transcription subunit 20; ubiquitin specific protease 49", "tax_id": 10116, "disease": "", "pathway": " (rno:316209); (R-RNO-9841922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000151 ubiquitin ligase complex;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0035914 skeletal muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIE9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46153-1", "uniprot_id": [ { "id": "GATA6_RAT", "url": "https://www.uniprot.org/uniprot/P46153", "type": "external" } ], "mass": 59168.0, "length": 587, "protein_name": "Transcription factor GATA-6", "gene_name": "Gata6", "organism": "Rat", "refseq_name": "transcription factor GATA-6", "refseq_ac": [ { "id": "NP_062058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062058", "type": "external" } ], "gene_names_uniprotkb": "Gata6", "gene_names_refseq": "Gata6", "protein_names_uniprotkb": "Transcription factor GATA-6; DNA-binding protein GATA-GT2; GATA-binding factor 6", "protein_names_refseq": "DNA-binding protein GATA-GT2; GATA-binding factor 6; transcription factor GATA-6", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Fukuyama congenital muscular dystrophy (Disease Ontology:DOID:0050559); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); atrioventricular septal defect (Disease Ontology:DOID:0050651); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); atrial heart septal defect 9 (Disease Ontology:DOID:0110114); autosomal recessive limb-girdle muscular dystrophy type 2D (Disease Ontology:DOID:0110278); autosomal recessive limb-girdle muscular dystrophy type 2P (Disease Ontology:DOID:0110293); congenital muscular dystrophy-dystroglycanopathy type A9 (Disease Ontology:DOID:0111232); pancreatic hypoplasia-diabetes-congenital heart disease syndrome (Disease Ontology:DOID:0111733); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); inclusion body myositis (Disease Ontology:DOID:3429); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); Klatskin's tumor (Disease Ontology:DOID:4927); myocardial infarction (Disease Ontology:DOID:5844); tetralogy of Fallot (Disease Ontology:DOID:6419); pulmonary hypertension (Disease Ontology:DOID:6432); muscular atrophy (Disease Ontology:DOID:767); Barrett's esophagus (Disease Ontology:DOID:9206); type 2 diabetes mellitus (Disease Ontology:DOID:9352); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:29300); (R-RNO-5683826); (R-RNO-983231)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "22673903;28167758;29859221;31949236;37059928;37531826;8083222;8248184", "class_list": "", "function": "GATA4/6 regulate DHH transcription in rat adrenocortical autografts. Publication Status: Online-Only, [RefSeq, PubMed]; GATA6 Inhibits Neuronal Autophagy and Ferroptosis in Cerebral ischemia-reperfusion Injury Through a miR-193b/ATG7 axis-dependent Mechanism., [RefSeq, PubMed]; GATA6 and StAR steroidogeneic genes are hypomethylated at specific CpG sites in prenatally androgenized rats, [RefSeq, PubMed]; GATA6 promotes fibrotic repair of tracheal injury through NLRP3 inflammasome-mediated epithelial pyroptosis., [RefSeq, PubMed]; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051525 NFAT protein binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0002759 regulation of antimicrobial humoral response;GO:0098773 skin epidermis development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0001889 liver development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P46153-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20037-1", "uniprot_id": [ { "id": "HA2B_RAT", "url": "https://www.uniprot.org/uniprot/P20037", "type": "external" } ], "mass": 28602.0, "length": 256, "protein_name": "Rano class II histocompatibility antigen, B alpha chain", "gene_name": "RT1-Ba", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RT1-Ba", "gene_names_refseq": "", "protein_names_uniprotkb": "Rano class II histocompatibility antigen, B alpha chain; RT1 class II antigen, Ba chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "autoimmune polyendocrine syndrome type 2 (Disease Ontology:DOID:0050168); marginal zone lymphoma (Disease Ontology:DOID:0050748); rheumatic heart disease (Disease Ontology:DOID:0050827); extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (Disease Ontology:DOID:0050909); stroke (Disease Ontology:DOID:0051061); paroxysmal nocturnal hemoglobinuria (Disease Ontology:DOID:0060284); lupus nephritis (Disease Ontology:DOID:0080162); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); stomach cancer (Disease Ontology:DOID:10534); glucose intolerance (Disease Ontology:DOID:10603); celiac disease (Disease Ontology:DOID:10608); hypertension (Disease Ontology:DOID:10763); lepromatous leprosy (Disease Ontology:DOID:10887); membranous glomerulonephritis (Disease Ontology:DOID:10976); IgA vasculitis (Disease Ontology:DOID:11123); rhinoscleroma (Disease Ontology:DOID:11336); onchocerciasis (Disease Ontology:DOID:11678); allergic disease (Disease Ontology:DOID:1205); factor VIII deficiency (Disease Ontology:DOID:12134); primary biliary cholangitis (Disease Ontology:DOID:12236); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); aplastic anemia (Disease Ontology:DOID:12449); choreatic disease (Disease Ontology:DOID:12859); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); congenital toxoplasmosis (Disease Ontology:DOID:13336); autoimmune polyendocrine syndrome (Disease Ontology:DOID:14040); colon carcinoma (Disease Ontology:DOID:1520); diffuse scleroderma (Disease Ontology:DOID:1580); rheumatic fever (Disease Ontology:DOID:1586); breast cancer (Disease Ontology:DOID:1612); hepatitis C (Disease Ontology:DOID:1883); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); multiple sclerosis (Disease Ontology:DOID:2377); thrombophilia (Disease Ontology:DOID:2452); asthma (Disease Ontology:DOID:2841); antiphospholipid syndrome (Disease Ontology:DOID:2988); brain infarction (Disease Ontology:DOID:3454); gastric adenocarcinoma (Disease Ontology:DOID:3717); autoimmune disease (Disease Ontology:DOID:417); systemic scleroderma (Disease Ontology:DOID:418); myasthenia gravis (Disease Ontology:DOID:437); rhinitis (Disease Ontology:DOID:4483); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myositis (Disease Ontology:DOID:633); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); rheumatoid arthritis (Disease Ontology:DOID:7148); autoimmune thyroiditis (Disease Ontology:DOID:7188); abdominal aortic aneurysm (Disease Ontology:DOID:7693); arthritis (Disease Ontology:DOID:848); chronic fatigue syndrome (Disease Ontology:DOID:8544); chronic myeloid leukemia (Disease Ontology:DOID:8552); psoriasis (Disease Ontology:DOID:8893); visceral leishmaniasis (Disease Ontology:DOID:9146); achalasia (Disease Ontology:DOID:9164); pemphigus (Disease Ontology:DOID:9182); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (R-RNO-202424); (R-RNO-202427); (R-RNO-202430); (R-RNO-202433); (R-RNO-2132295); (R-RNO-389948)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "3610254", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 67, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0023026 MHC class II protein complex binding;GO:0042605 peptide antigen binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0009897 external side of plasma membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0042130 negative regulation of T cell proliferation;GO:0002503 peptide antigen assembly with MHC class II protein complex;GO:0002250 adaptive immune response;GO:0071385 cellular response to glucocorticoid stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P20037-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CE43-1", "uniprot_id": [ { "id": "GRB10_RAT", "url": "https://www.uniprot.org/uniprot/P0CE43", "type": "external" } ], "mass": 67882.0, "length": 599, "protein_name": "Growth factor receptor-bound protein 10", "gene_name": "Grb10", "organism": "Rat", "refseq_name": "growth factor receptor-bound protein 10 isoform 1", "refseq_ac": [ { "id": "NP_001388332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388332", "type": "external" } ], "gene_names_uniprotkb": "Grb10", "gene_names_refseq": "Grb10; RGD1566234", "protein_names_uniprotkb": "Growth factor receptor-bound protein 10; GRB10 adapter protein", "protein_names_refseq": "GRB10 adapter protein; Growth factor receptor-bound protein 10; growth factor receptor-bound protein 10 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:498416); (R-RNO-1433557); (R-RNO-74713); (R-RNO-74749); (R-RNO-74751); (R-RNO-8853659); (R-RNO-9607240)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "23614367;24149516", "class_list": "", "function": "Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination also has been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2 (By similarity)., [UniProtKB]; Findings indicate that endogenous overexpression of Grb10 functions as a suppressor of the IGF1-IR pathway, which may represent an important mechanism for regulating cognitive disorder in diabetes, [RefSeq, PubMed]; In rat uterus, enforced miR199a expression suppresses cell proliferation partially through targeting Grb10. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0032868 response to insulin;GO:0070371 ERK1 and ERK2 cascade;GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0CE43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35571-1", "uniprot_id": [ { "id": "GPDM_RAT", "url": "https://www.uniprot.org/uniprot/P35571", "type": "external" } ], "mass": 80973.0, "length": 727, "protein_name": "Glycerol-3-phosphate dehydrogenase, mitochondrial", "gene_name": "Gpd2", "organism": "Rat", "refseq_name": "glycerol-3-phosphate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_036868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036868", "type": "external" } ], "gene_names_uniprotkb": "Gpd2", "gene_names_refseq": "Gpd2; mtGPDH", "protein_names_uniprotkb": "Glycerol-3-phosphate dehydrogenase, mitochondrial; 1.1.5.3; GPD-M; GPDH-M", "protein_names_refseq": "GPD-M; GPDH-M; Glycerol-3-phosophate dehydrogenase 2 (mitochondrial); glycerol-3-phosphate dehydrogenase 2, mitochondrial; glycerol-3-phosphate dehydrogenase, mitochondrial precursor; glycerol-3-phosphate dehydrogenase, mitochondrial; mtGPDH gene, promoter region and alternative transcripts", "tax_id": 10116, "disease": "brain ischemia (Disease Ontology:DOID:2316); nephrosis (Disease Ontology:DOID:2527); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); borna disease (Disease Ontology:DOID:5154); ureteral obstruction (Disease Ontology:DOID:5199); myxoid liposarcoma (Disease Ontology:DOID:5363); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); type 2 diabetes mellitus (Disease Ontology:DOID:9352); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (rno:25062); (R-RNO-1483166); (R-RNO-163560)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "17886033;17973206;23999537;7937996;8182039", "class_list": "", "function": "By this approach, we also directly demonstrated that isolated mGPDH itself as well as its supramolecular assemblies are all capable of ROS production., [RefSeq, PubMed]; Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The up-regulation of mGPDH, due to a highly glycolytic environment, contributes to the overall increase in ROS generation and may result in the progression of prostate cancer, [RefSeq, PubMed]; These results show that leptin downregulates mGPD activity, mainly when hyperleptinemia is chronic., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.3", "type": "external" } ], "go_molecular_function": "GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0006127 glycerol-3-phosphate shuttle;GO:0035264 multicellular organism growth;GO:0006094 gluconeogenesis;GO:0006072 glycerol-3-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P35571-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12336-1", "uniprot_id": [ { "id": "GTR2_RAT", "url": "https://www.uniprot.org/uniprot/P12336", "type": "external" } ], "mass": 57086.0, "length": 522, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 2", "gene_name": "Slc2a2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc2a2; Glut2", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 2; GLUT-2; Glucose transporter type 2, liver", "protein_names_refseq": "", "tax_id": 10116, "disease": "Fanconi-Bickel syndrome (Disease Ontology:DOID:0070562); glycogen storage disease (Disease Ontology:DOID:2747); insulinoma (Disease Ontology:DOID:3892); gastrinoma (Disease Ontology:DOID:5577); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-RNO-189200); (R-RNO-422356); (R-RNO-8981373)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21454685;22673903;3048704;7487103", "class_list": "", "function": "Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:3048704). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cells (PubMed:3048704). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (By similarity). Also able to mediate the transport of dehydroascorbate and urate (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6LE98", "ec_number_list": [], "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005158 insulin receptor binding;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005911 cell-cell junction", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0009749 response to glucose;GO:0043434 response to peptide hormone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P12336-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19356-1", "uniprot_id": [ { "id": "HEM3_RAT", "url": "https://www.uniprot.org/uniprot/P19356", "type": "external" } ], "mass": 39361.0, "length": 361, "protein_name": "Porphobilinogen deaminase", "gene_name": "Hmbs", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hmbs", "gene_names_refseq": "", "protein_names_uniprotkb": "Porphobilinogen deaminase; 2.5.1.61; HMBS; Hydroxymethylbilane synthase; PBG-D; Pre-uroporphyrinogen synthase", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate carcinoma (Disease Ontology:DOID:10286); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); cancer (Disease Ontology:DOID:162); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute intermittent porphyria (Disease Ontology:DOID:3890); seminoma (Disease Ontology:DOID:4440); liver carcinoma (Disease Ontology:DOID:686)", "pathway": " (rno:25709); (R-RNO-189451)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15240697;3368319;9344466;9712715", "class_list": "", "function": "As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08568", "ec_number_list": [ { "id": "2.5.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.61", "type": "external" } ], "go_molecular_function": "GO:0004418 hydroxymethylbilane synthase activity;GO:0031406 carboxylic acid binding;GO:0004852 uroporphyrinogen-III synthase activity;GO:0043176 amine binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0033273 response to vitamin;GO:0048708 astrocyte differentiation;GO:0001889 liver development;GO:0010043 response to zinc ion;GO:0010288 response to lead ion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19356-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13697-1", "uniprot_id": [ { "id": "MAOX_RAT", "url": "https://www.uniprot.org/uniprot/P13697", "type": "external" } ], "mass": 64003.0, "length": 572, "protein_name": "NADP-dependent malic enzyme", "gene_name": "Me1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Me1; Mod-1; Mod1", "gene_names_refseq": "", "protein_names_uniprotkb": "NADP-dependent malic enzyme; 1.1.1.40; Malic enzyme 1; NADP-ME", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-70268); (R-RNO-9861718)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22673903;2416344;2699453;2740332;3211151;3753699", "class_list": "", "function": "Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.1.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.40", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.7.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.5", "type": "external" }, { "id": "4.1.1.112", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.112", "type": "external" }, { "id": "5.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.2", "type": "external" } ], "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0042802 identical protein binding;GO:0051287 NAD binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0051289 protein homotetramerization;GO:0019674 NAD+ metabolic process;GO:0009725 response to hormone;GO:0006108 malate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P13697-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQS4-1", "uniprot_id": [ { "id": "GULP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQS4", "type": "external" } ], "mass": 34285.0, "length": 304, "protein_name": "PTB domain-containing engulfment adapter protein 1", "gene_name": "Gulp1", "organism": "Rat", "refseq_name": "PTB domain-containing engulfment adapter protein 1", "refseq_ac": [ { "id": "NP_001013189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013189", "type": "external" } ], "gene_names_uniprotkb": "Gulp1; Ced6", "gene_names_refseq": "CED-6; Gulp1", "protein_names_uniprotkb": "PTB domain-containing engulfment adapter protein 1; Cell death protein 6 homolog; PTB domain adapter protein CED-6; Protein GULP", "protein_names_refseq": "GULP, engulfment adaptor PTB domain containing 1; PTB domain adapter protein CED-6; PTB domain-containing engulfment adapter protein 1; cell death protein 6 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:314543)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17007823", "class_list": "", "function": "May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 (By similarity)., [UniProtKB]; The present findings suggest that CED-6 may have a role in endocytic trafficking or signaling in neurons., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0PYK2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006869 lipid transport;GO:0006911 phagocytosis, engulfment;GO:0006915 apoptotic process;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88387-1", "uniprot_id": [ { "id": "FGD4_RAT", "url": "https://www.uniprot.org/uniprot/O88387", "type": "external" } ], "mass": 86454.0, "length": 766, "protein_name": "FYVE, RhoGEF and PH domain-containing protein 4", "gene_name": "Fgd4", "organism": "Rat", "refseq_name": "FYVE, RhoGEF and PH domain-containing protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001401984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401984", "type": "external" } ], "gene_names_uniprotkb": "Fgd4", "gene_names_refseq": "Fgd4", "protein_names_uniprotkb": "FYVE, RhoGEF and PH domain-containing protein 4; Actin filament-binding protein frabin; FGD1-related F-actin-binding protein", "protein_names_refseq": "FGD1-related F-actin-binding protein; FYVE, RhoGEF and PH domain-containing protein 4 isoform 2; FYVE, RhoGEF and PH domain-containing protein 4; actin filament-binding protein frabin", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 4H (Disease Ontology:DOID:0110192); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); X-linked Aarskog syndrome (Disease Ontology:DOID:6683)", "pathway": " (rno:246174); (R-RNO-193648); (R-RNO-416482); (R-RNO-9013148)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10464238;9668039", "class_list": "", "function": "Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0051015 actin filament binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030027 lamellipodium;GO:0030175 filopodium", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0046847 filopodium assembly;GO:0007010 cytoskeleton organization;GO:0030032 lamellipodium assembly;GO:0030035 microspike assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88387-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G050-1", "uniprot_id": [ { "id": "MKNK1_RAT", "url": "https://www.uniprot.org/uniprot/Q4G050", "type": "external" } ], "mass": 46214.0, "length": 413, "protein_name": "MAP kinase-interacting serine/threonine-protein kinase 1", "gene_name": "Mknk1", "organism": "Rat", "refseq_name": "MAP kinase-interacting serine/threonine-protein kinase 1", "refseq_ac": [ { "id": "NP_001037732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037732", "type": "external" } ], "gene_names_uniprotkb": "Mknk1; Mnk1", "gene_names_refseq": "Mknk1", "protein_names_uniprotkb": "MAP kinase-interacting serine/threonine-protein kinase 1; 2.7.11.1; MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1", "protein_names_refseq": "MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine kinase 1; MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal-integrating kinase 1; mnk1", "tax_id": 10116, "disease": "", "pathway": " (rno:500526); (R-RNO-1295596)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "25453757", "class_list": "", "function": "Long-term potentiation (LTP) consolidation in the dentate gyrus of live rodents requires sustained (hours) BDNF-TrkB signaling and from TrkB to MAP-kinase-interacting kinase., [RefSeq, PubMed]; May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0009651 response to salt stress;GO:0006446 regulation of translational initiation;GO:0018105 peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4G050-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38406-1", "uniprot_id": [ { "id": "GNAL_RAT", "url": "https://www.uniprot.org/uniprot/P38406", "type": "external" } ], "mass": 44248.0, "length": 381, "protein_name": "Guanine nucleotide-binding protein G(olf) subunit alpha", "gene_name": "Gnal", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(olf) subunit alpha", "refseq_ac": [ { "id": "NP_001178765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178765", "type": "external" } ], "gene_names_uniprotkb": "Gnal", "gene_names_refseq": "Gnal; Golf; Olf; RGD1305940", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(olf) subunit alpha; 3.6.5.-; Adenylate cyclase-stimulating G alpha protein, olfactory type", "protein_names_refseq": "Olf-alpha protein (olfactory neuron-specific G protein); adenylate cyclase-stimulating G alpha protein, olfactory type; guanine nucleotide binding protein, alpha activating activity polypeptide, olfactory type; guanine nucleotide binding protein, alpha stimulating, olfactory type; guanine nucleotide-binding protein G(olf) subunit alpha; guanine nucleotide-binding protein G(olf), alpha subunit", "tax_id": 10116, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292); dystonia 25 (Disease Ontology:DOID:0090055); hypertension (Disease Ontology:DOID:10763); cardiovascular system disease (Disease Ontology:DOID:1287); McCune Albright syndrome (Disease Ontology:DOID:1858); coronary artery disease (Disease Ontology:DOID:3393); dystonia (Disease Ontology:DOID:543)", "pathway": " (rno:24611); (R-RNO-170660); (R-RNO-170670)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "2255909;22673903;2499043;26934374;29215295;38182074;7494450", "class_list": "", "function": "CAMP signaling pathway-related proteins, Pde10a and Gnal, may play important roles in the pathogenesis and recovery of mild traumatic brain injury., [RefSeq, PubMed]; Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs) (PubMed:2255909, PubMed:2499043). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (PubMed:2255909, PubMed:2499043). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (PubMed:2255909)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Loss-of-function of GNAL dystonia gene impairs striatal dopamine receptors-mediated adenylyl cyclase/ cyclic AMP signaling pathway., [RefSeq, PubMed]; The major components of the olfactory transduction pathway in the rat choroid plexus have been determined, including odorant receptors, Galphaolf, adenylate cyclase 3 and CNGA2., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q64711", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium;GO:0001669 acrosomal vesicle;GO:0097225 sperm midpiece", "go_biological_process": "GO:1900452 regulation of long-term synaptic depression;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007190 activation of adenylate cyclase activity;GO:0001975 response to amphetamine;GO:0031000 response to caffeine", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P38406-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08462-1", "uniprot_id": [ { "id": "GRPB_RAT", "url": "https://www.uniprot.org/uniprot/P08462", "type": "external" } ], "mass": 26948.0, "length": 247, "protein_name": "Submandibular gland secretory Glx-rich protein CB", "gene_name": "Grpcb; Prr4", "organism": "Rat", "refseq_name": "submandibular gland secretory Glx-rich protein CB precursor", "refseq_ac": [ { "id": "NP_976077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_976077", "type": "external" } ], "gene_names_uniprotkb": "Grpcb; Prr4; Grpcb; LOC100360165", "gene_names_refseq": "CRP; GRP-CA; GRP-CB; Grpca; Grpcb; Prr4", "protein_names_uniprotkb": "Submandibular gland secretory Glx-rich protein CB; CRP; Contiguous repeat polypeptide; GRP-CB", "protein_names_refseq": "Submandibular gland secretory Glx-rich protein CA; contiguous repeat polypeptide; glutamine/glutamic acid-rich protein A; glutamine/glutamic acid-rich protein B; hypothetical gene supported by M31032, NM_181440; rCG29588-like; submandibular gland secretory Glx-rich protein CB precursor; submandibular gland secretory Glx-rich protein CB", "tax_id": 10116, "disease": "", "pathway": " (rno:120093082); (rno:360395)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1995617;3558393", "class_list": "", "function": "GRP proteins have a marked affinity for hydroxyapatite. They may play a role in the formation of the protective acquired pellicle at the saliva-tooth interface., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0031214 biomineral tissue development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P08462-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97609-1", "uniprot_id": [ { "id": "HAIR_RAT", "url": "https://www.uniprot.org/uniprot/P97609", "type": "external" } ], "mass": 127307.0, "length": 1181, "protein_name": "Lysine-specific demethylase hairless", "gene_name": "Hr", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Hr", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysine-specific demethylase hairless; 1.14.11.65; [histone H3]-dimethyl-L-lysine(9) demethylase hairless", "protein_names_refseq": "", "tax_id": 10116, "disease": "alopecia universalis (Disease Ontology:DOID:0050634); atrichia with papular lesions (Disease Ontology:DOID:0060689); hypotrichosis 4 (Disease Ontology:DOID:0110701); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); alcohol use disorder (Disease Ontology:DOID:1574); proteinuria (Disease Ontology:DOID:576); alopecia (Disease Ontology:DOID:987)", "pathway": " (rno:60563)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14570920;8987811", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0044877 protein-containing complex binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0070988 demethylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P97609-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88368-1", "uniprot_id": [ { "id": "MITF_RAT", "url": "https://www.uniprot.org/uniprot/O88368", "type": "external" } ], "mass": 58585.0, "length": 526, "protein_name": "Microphthalmia-associated transcription factor", "gene_name": "Mitf", "organism": "Rat", "refseq_name": "microphthalmia-associated transcription factor isoform 1", "refseq_ac": [ { "id": "NP_001178018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178018", "type": "external" } ], "gene_names_uniprotkb": "Mitf", "gene_names_refseq": "Mitf", "protein_names_uniprotkb": "Microphthalmia-associated transcription factor", "protein_names_refseq": "melanogenesis associated transcription factor; microphthalmia-associated transcription factor isoform 1; microphthalmia-associated transcription factor", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); abdominal obesity-metabolic syndrome 3 (Disease Ontology:DOID:0060612); Tietz syndrome (Disease Ontology:DOID:0090002); ocular albinism with sensorineural deafness (Disease Ontology:DOID:0090100); Waardenburg syndrome type 1 (Disease Ontology:DOID:0110948); Waardenburg syndrome type 2A (Disease Ontology:DOID:0110950); intellectual disability (Disease Ontology:DOID:1059); osteopetrosis (Disease Ontology:DOID:13533); Tietze's syndrome (Disease Ontology:DOID:14021); Down syndrome (Disease Ontology:DOID:14250); melanoma (Disease Ontology:DOID:1909); lysosomal storage disease (Disease Ontology:DOID:3211); Camurati-Engelmann disease (Disease Ontology:DOID:4997); familial melanoma (Disease Ontology:DOID:6846); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (rno:25094); (R-RNO-3232118); (R-RNO-9824594); (R-RNO-9856649)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "26388265;9480987", "class_list": "", "function": "MITF interacts with BRG1 to promote GATA4 expression in cardiac hypertrophy., [RefSeq, PubMed]; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LQV3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005765 lysosomal membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:2001141 regulation of RNA biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88368-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2VUH7-1", "uniprot_id": [ { "id": "DIXC1_RAT", "url": "https://www.uniprot.org/uniprot/Q2VUH7", "type": "external" } ], "mass": 77303.0, "length": 684, "protein_name": "Dixin", "gene_name": "Dixdc1", "organism": "Rat", "refseq_name": "dixin", "refseq_ac": [ { "id": "NP_001382076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382076", "type": "external" } ], "gene_names_uniprotkb": "Dixdc1; Ccd1", "gene_names_refseq": "Ccd1; Dixdc1", "protein_names_uniprotkb": "Dixin; Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain-containing protein 1", "protein_names_refseq": "DIX domain-containing protein 1; coiled-coil protein DIX1; coiled-coil-DIX1; dixin", "tax_id": 10116, "disease": "", "pathway": " (rno:363062)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17554179;19339625;27521891;27873129", "class_list": "", "function": "Findings define a novel SnoN-Ccd1 link that promotes axonal growth in the mammalian brain, with important implications for axonal development and regeneration, [RefSeq, PubMed]; Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The DIX domain of rat axin, which is important for its homooligomerization and interactions with other regulators in the Wnt pathway, has been purified and crystallized., [RefSeq, PubMed]; These data demonstrated that Dixdc1 might participate in Schwann cell proliferation by targeting CyclinD1 and p21 at least partially through the PI3K/AKT activation., [RefSeq, PubMed]; Up-regulation of Dixdc1 protein expression is potentially involved in astrocyte proliferation after traumatic brain injury in the rat., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0043015 gamma-tubulin binding;GO:0031435 mitogen-activated protein kinase kinase kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0021799 cerebral cortex radially oriented cell migration;GO:0021869 forebrain ventricular zone progenitor cell division;GO:0032956 regulation of actin cytoskeleton organization;GO:0045665 negative regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q2VUH7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQS3-1", "uniprot_id": [ { "id": "MELT_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQS3", "type": "external" } ], "mass": 94463.0, "length": 832, "protein_name": "Ventricular zone-expressed PH domain-containing protein homolog 1", "gene_name": "Veph1", "organism": "Rat", "refseq_name": "ventricular zone-expressed PH domain-containing protein homolog 1", "refseq_ac": [ { "id": "NP_001014193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014193", "type": "external" } ], "gene_names_uniprotkb": "Veph1", "gene_names_refseq": "RGD1308217; Veph1", "protein_names_uniprotkb": "Ventricular zone-expressed PH domain-containing protein homolog 1; Protein melted homolog", "protein_names_refseq": "protein melted homolog; ventricular zone expressed PH domain homolog 1; ventricular zone-expressed PH domain-containing protein homolog 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361954)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060392 negative regulation of SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQS3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88281-1", "uniprot_id": [ { "id": "MEGF6_RAT", "url": "https://www.uniprot.org/uniprot/O88281", "type": "external" } ], "mass": 165447.0, "length": 1574, "protein_name": "Multiple epidermal growth factor-like domains protein 6", "gene_name": "Megf6", "organism": "Rat", "refseq_name": "multiple epidermal growth factor-like domains protein 6 precursor", "refseq_ac": [ { "id": "NP_075244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075244", "type": "external" } ], "gene_names_uniprotkb": "Megf6; Egfl3", "gene_names_refseq": "Egfl3; Megf6", "protein_names_uniprotkb": "Multiple epidermal growth factor-like domains protein 6; EGF-like protein 3; Epidermal growth factor-like protein 3; Multiple EGF-like domains protein 6", "protein_names_refseq": "EGF-like domain-containing protein 3; EGF-like-domain, multiple 3; epidermal growth factor-like protein 3; multiple EGF-like domain protein 3; multiple EGF-like domains protein 6; multiple epidermal growth factor-like domains 6; multiple epidermal growth factor-like domains protein 6 precursor; multiple epidermal growth factor-like domains protein 6-like; multiple epidermal growth factor-like domains protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:65049)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9693030", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88281-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8C9-1", "uniprot_id": [ { "id": "LRC56_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8C9", "type": "external" } ], "mass": 60488.0, "length": 548, "protein_name": "Leucine-rich repeat-containing protein 56", "gene_name": "Lrrc56", "organism": "Rat", "refseq_name": "leucine-rich repeat-containing protein 56", "refseq_ac": [ { "id": "NP_001020073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020073", "type": "external" } ], "gene_names_uniprotkb": "Lrrc56", "gene_names_refseq": "Lrrc56; RGD1311654", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 56", "protein_names_refseq": "leucine-rich repeat-containing protein 56", "tax_id": 10116, "disease": "primary ciliary dyskinesia 39 (Disease Ontology:DOID:0111854)", "pathway": " (rno:365389)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the assembly of dynein arms., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8C9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQT2-1", "uniprot_id": [ { "id": "MTMR3_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQT2", "type": "external" } ], "mass": 133500.0, "length": 1194, "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3", "gene_name": "Mtmr3", "organism": "Rat", "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform 1", "refseq_ac": [ { "id": "NP_001012038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012038", "type": "external" } ], "gene_names_uniprotkb": "Mtmr3", "gene_names_refseq": "Mtmr3", "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3; 3.1.3.95; Myotubularin-related protein 3; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3 isoform 1; phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 10116, "disease": "centronuclear myopathy X-linked (Disease Ontology:DOID:0111225); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595)", "pathway": " (rno:305482); (R-RNO-1632852); (R-RNO-1660499)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic. Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0019903 protein phosphatase binding;GO:0008138 protein tyrosine/serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0042149 cellular response to glucose starvation;GO:0060304 regulation of phosphatidylinositol dephosphorylation;GO:0006470 protein dephosphorylation;GO:0006661 phosphatidylinositol biosynthetic process;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQT2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35353-1", "uniprot_id": [ { "id": "GBB4_RAT", "url": "https://www.uniprot.org/uniprot/O35353", "type": "external" } ], "mass": 37363.0, "length": 340, "protein_name": "Guanine nucleotide-binding protein subunit beta-4", "gene_name": "Gnb4", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein subunit beta-4", "refseq_ac": [ { "id": "NP_001013932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013932", "type": "external" } ], "gene_names_uniprotkb": "Gnb4", "gene_names_refseq": "Gnb4", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit beta-4; Transducin beta chain 4", "protein_names_refseq": "G-protein beta 4 subunit; guanine nucleotide binding protein (G protein), beta 4; guanine nucleotide binding protein (G protein), beta polypeptide 4; guanine nucleotide binding protein beta 4 subunit; guanine nucleotide binding protein, beta 4; guanine nucleotide-binding protein subunit beta-4-like; guanine nucleotide-binding protein subunit beta-4; transducin beta chain 4", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease dominant intermediate F (Disease Ontology:DOID:0110206)", "pathway": " (rno:294962); (R-RNO-1296041); (R-RNO-202040); (R-RNO-381676); (R-RNO-392170); (R-RNO-392451); (R-RNO-400042); (R-RNO-4086398); (R-RNO-416476); (R-RNO-418594); (R-RNO-418597); (R-RNO-420092); (R-RNO-428930); (R-RNO-432040); (R-RNO-456926); (R-RNO-6814122); (R-RNO-8964616); (R-RNO-9856530); (R-RNO-997272)", "pathway_count": 19, "publication_count": 2, "publication_id_list": "22711958;9622245", "class_list": "", "function": "Gnb2 and Gnb4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons, [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V8I8;Q6Q8B2", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0044297 cell body;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35353-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52KJ8-1", "uniprot_id": [ { "id": "MSRB1_RAT", "url": "https://www.uniprot.org/uniprot/Q52KJ8", "type": "external" } ], "mass": 12797.0, "length": 116, "protein_name": "Methionine-R-sulfoxide reductase B1", "gene_name": "Msrb1", "organism": "Rat", "refseq_name": "methionine-R-sulfoxide reductase B1", "refseq_ac": [ { "id": "NP_001037750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037750", "type": "external" } ], "gene_names_uniprotkb": "Msrb1; Sepx1", "gene_names_refseq": "Msrb1; Sepx1; selX", "protein_names_uniprotkb": "Methionine-R-sulfoxide reductase B1; 1.8.4.12; 1.8.4.14; MsrB1; SelX; Selenoprotein X", "protein_names_refseq": "methionine-R-sulfoxide reductase B1; selenoprotein R; selenoprotein X, 1", "tax_id": 10116, "disease": "", "pathway": " (rno:685059); (R-RNO-5676934)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "27752786", "class_list": "", "function": "Data show that 15kD selenoprotein (SEP15) protein and selenoprotein R (SELR) protein expression was decreased in the lenses of galactose induced cataract., [RefSeq, PubMed]; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Oct 2016]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.12", "type": "external" }, { "id": "1.8.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.14", "type": "external" } ], "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0033745 L-methionine-(R)-S-oxide reductase activity;GO:0003779 actin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0045087 innate immune response;GO:0030041 actin filament polymerization;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q52KJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7F5A1-1", "uniprot_id": [ { "id": "F7F5A1_RAT", "url": "https://www.uniprot.org/uniprot/F7F5A1", "type": "external" } ], "mass": 49631.0, "length": 463, "protein_name": "E2 ubiquitin-conjugating enzyme", "gene_name": "Ube2e3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ube2e3", "gene_names_refseq": "", "protein_names_uniprotkb": "E2 ubiquitin-conjugating enzyme; 2.3.2.23", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-8866652); (R-RNO-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0ZFT2", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0070534 protein K63-linked ubiquitination;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7F5A1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27645-1", "uniprot_id": [ { "id": "FCGR3_RAT", "url": "https://www.uniprot.org/uniprot/P27645", "type": "external" } ], "mass": 30282.0, "length": 267, "protein_name": "Low affinity immunoglobulin gamma Fc region receptor III", "gene_name": "Fcgr2al1; Fcgr2a; Fcgr2b; Fcgr3", "organism": "Rat", "refseq_name": "low affinity immunoglobulin gamma Fc region receptor III isoform 1", "refseq_ac": [ { "id": "NP_446295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446295", "type": "external" } ], "gene_names_uniprotkb": "Fcgr2al1; Fcgr2a; Fcgr2b; Fcgr3; Fcgr2a-ps1; Fcgr2al1; LOC134481532; LOC498276", "gene_names_refseq": "Fcgr2a; Fcgr3a; Fcgr3; fc-gamma RIII; fcRIII", "protein_names_uniprotkb": "Low affinity immunoglobulin gamma Fc region receptor III; Fc-gamma RIII; FcRIII; IgG Fc receptor III", "protein_names_refseq": "Fc fragment of IgG low affinity IIa receptor for (CD32); Fc fragment of IgG receptor IIa; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc gamma receptor IIa; Fc receptor, IgG, low affinity III; igG Fc receptor III; low affinity immunoglobulin gamma Fc region receptor III isoform 1; low affinity immunoglobulin gamma Fc region receptor III", "tax_id": 10116, "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); stroke (Disease Ontology:DOID:0051061); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); thrombosis (Disease Ontology:DOID:0060903); lupus nephritis (Disease Ontology:DOID:0080162); haemophilus meningitis (Disease Ontology:DOID:0080179); lymphoid leukemia (Disease Ontology:DOID:1037); hemolytic disease of the fetus (Disease Ontology:DOID:1098); factor VIII deficiency (Disease Ontology:DOID:12134); common variable immunodeficiency (Disease Ontology:DOID:12177); dengue disease (Disease Ontology:DOID:12205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); neutropenia (Disease Ontology:DOID:1227); malaria (Disease Ontology:DOID:12365); crescentic glomerulonephritis (Disease Ontology:DOID:13139); temporal arteritis (Disease Ontology:DOID:13375); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); cystic fibrosis (Disease Ontology:DOID:1485); arthus reaction (Disease Ontology:DOID:1556); respiratory system disease (Disease Ontology:DOID:1579); diffuse scleroderma (Disease Ontology:DOID:1580); thrombocytopenia (Disease Ontology:DOID:1588); epilepsy (Disease Ontology:DOID:1826); atherosclerosis (Disease Ontology:DOID:1936); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); hemolytic anemia (Disease Ontology:DOID:583); lymphopenia (Disease Ontology:DOID:614); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); systemic lupus erythematosus (Disease Ontology:DOID:9074); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:116591); (rno:498276)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1692135;1710249;22673903;29393594;38544414;8482840", "class_list": "", "function": "Receptor for the Fc region of complexed immunoglobulins gamma (PubMed:1692135). Low affinity receptor which binds to IgG1, IgG2a and IgG2b (By similarity). Mediates neutrophil activation by IgG complexes redundantly with Fcgr4 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 38, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q04798;Q63204", "ec_number_list": [], "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0019864 IgG binding;GO:0019770 IgG receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway;GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0006911 phagocytosis, engulfment;GO:0007166 cell surface receptor signaling pathway;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P27645-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03957-1", "uniprot_id": [ { "id": "MMP3_RAT", "url": "https://www.uniprot.org/uniprot/P03957", "type": "external" } ], "mass": 53428.0, "length": 475, "protein_name": "Stromelysin-1", "gene_name": "Mmp3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mmp3", "gene_names_refseq": "", "protein_names_uniprotkb": "Stromelysin-1; 3.4.24.17; MMP-3; Matrix metalloproteinase-3; PTR1 protein; SL-1; Transin-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); Parkinsonism (Disease Ontology:DOID:0080855); immunoglobulin light chain amyloidosis (Disease Ontology:DOID:0080933); gastric ulcer (Disease Ontology:DOID:10808); Alport syndrome (Disease Ontology:DOID:10983); cartilage disease (Disease Ontology:DOID:1222); primary biliary cholangitis (Disease Ontology:DOID:12236); Sjogren's syndrome (Disease Ontology:DOID:12894); carotid stenosis (Disease Ontology:DOID:13001); crescentic glomerulonephritis (Disease Ontology:DOID:13139); lung cancer (Disease Ontology:DOID:1324); von Hippel-Lindau disease (Disease Ontology:DOID:14175); cognitive disorder (Disease Ontology:DOID:1561); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); arteriosclerosis (Disease Ontology:DOID:2349); Takayasu's arteritis (Disease Ontology:DOID:2508); glomerulonephritis (Disease Ontology:DOID:2921); allergic contact dermatitis (Disease Ontology:DOID:3042); coronary artery disease (Disease Ontology:DOID:3393); systemic scleroderma (Disease Ontology:DOID:418); conjunctivochalasis (Disease Ontology:DOID:4250); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); cataract (Disease Ontology:DOID:83); osteoarthritis (Disease Ontology:DOID:8398); polymyalgia rheumatica (Disease Ontology:DOID:853); degenerative disc disease (Disease Ontology:DOID:90); psoriatic arthritis (Disease Ontology:DOID:9008); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-RNO-1442490); (R-RNO-1474228); (R-RNO-1592389); (R-RNO-2022090); (R-RNO-2179392); (R-RNO-9009391)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "1963430;1988438;2431284;2841336;3875482", "class_list": "", "function": "Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase., [UniProtKB, PubMed]; Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage. In addition, plays a role in immune response and possesses antiviral activity against various viruses. Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 23, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 40, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "3.4.21.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030425 dendrite;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030335 positive regulation of cell migration;GO:0032496 response to lipopolysaccharide;GO:0034612 response to tumor necrosis factor", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P03957-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13265-1", "uniprot_id": [ { "id": "GPC3_RAT", "url": "https://www.uniprot.org/uniprot/P13265", "type": "external" } ], "mass": 67049.0, "length": 597, "protein_name": "Glypican-3", "gene_name": "Gpc3", "organism": "Rat", "refseq_name": "glypican-3 precursor", "refseq_ac": [ { "id": "NP_036906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036906", "type": "external" } ], "gene_names_uniprotkb": "Gpc3", "gene_names_refseq": "Gpc3; OCI-5", "protein_names_uniprotkb": "Glypican-3; Intestinal protein OCI-5", "protein_names_refseq": "defective in Simpson-Golabi-Behmel overgrowth syndrome; glypican-3 precursor; intestinal protein OCI-5; proteoglycan GPC3", "tax_id": 10116, "disease": "Simpson-Golabi-Behmel syndrome type 1 (Disease Ontology:DOID:0060248); atypical teratoid rhabdoid tumor (Disease Ontology:DOID:2129); nephroblastoma (Disease Ontology:DOID:2154); placental site trophoblastic tumor (Disease Ontology:DOID:3596); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687)", "pathway": " (rno:25236); (R-RNO-1971475); (R-RNO-2022928); (R-RNO-2024096); (R-RNO-381426); (R-RNO-8957275); (R-RNO-975634); (R-RNO-9769739)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "3185547;7487896;9065409", "class_list": "", "function": "Cell surface proteoglycan (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cell surface proteoglycan., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5U326", "ec_number_list": [], "go_molecular_function": "GO:0060422 peptidyl-dipeptidase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0005764 lysosome;GO:0098552 side of membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0045880 positive regulation of smoothened signaling pathway;GO:0010171 body morphogenesis;GO:0072180 mesonephric duct morphogenesis;GO:0072203 cell proliferation involved in metanephros development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P13265-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60756-1", "uniprot_id": [ { "id": "MDGA2_RAT", "url": "https://www.uniprot.org/uniprot/P60756", "type": "external" } ], "mass": 106719.0, "length": 949, "protein_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2", "gene_name": "Mdga2", "organism": "Rat", "refseq_name": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform 1 precursor", "refseq_ac": [ { "id": "NP_954890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954890", "type": "external" } ], "gene_names_uniprotkb": "Mdga2; Mamdc1", "gene_names_refseq": "Mamdc1; Mdga2", "protein_names_uniprotkb": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2; MAM domain-containing protein 1", "protein_names_refseq": "MAM domain-containing glycosylphosphatidylinositol anchor protein 2 isoform 1 precursor; MAM domain-containing glycosylphosphatidylinositol anchor protein 2; MAM domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:314180); (R-RNO-163125)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15019943;23248271", "class_list": "", "function": "MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development. Erratum:[Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2410442121. doi: 10.1073/pnas.2410442121. PMID: 38885391], [RefSeq, PubMed]; May be involved in cell-cell interactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098839 postsynaptic density membrane;GO:0098552 side of membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0050905 neuromuscular process;GO:0001764 neuron migration;GO:0043524 negative regulation of neuron apoptotic process;GO:0021522 spinal cord motor neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P60756-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U308-1", "uniprot_id": [ { "id": "LRC8D_RAT", "url": "https://www.uniprot.org/uniprot/Q5U308", "type": "external" } ], "mass": 97940.0, "length": 858, "protein_name": "Volume-regulated anion channel subunit LRRC8D", "gene_name": "Lrrc8d", "organism": "Rat", "refseq_name": "volume-regulated anion channel subunit LRRC8D", "refseq_ac": [ { "id": "NP_001008339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008339", "type": "external" } ], "gene_names_uniprotkb": "Lrrc8d; Lrrc5", "gene_names_refseq": "Lrrc5; Lrrc8d", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8D; Leucine-rich repeat-containing protein 5; Leucine-rich repeat-containing protein 8D", "protein_names_refseq": "leucine rich repeat containing 8 family, member D; leucine rich repeat containing 8D; leucine-rich repeat-containing 5; leucine-rich repeat-containing protein 5; leucine-rich repeat-containing protein 8D; volume-regulated anion channel subunit LRRC8D", "tax_id": 10116, "disease": "", "pathway": " (rno:305131); (R-RNO-5223345)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "28833202;38843836", "class_list": "", "function": "Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:28833202). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:28833202). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005225 volume-sensitive anion channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0001678 intracellular glucose homeostasis;GO:0015734 taurine transmembrane transport;GO:0071470 cellular response to osmotic stress;GO:0034214 protein hexamerization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5U308-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BKC6-1", "uniprot_id": [ { "id": "HBAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BKC6", "type": "external" } ], "mass": 54209.0, "length": 479, "protein_name": "HSPB1-associated protein 1", "gene_name": "Hspbap1", "organism": "Rat", "refseq_name": "HSPB1-associated protein 1", "refseq_ac": [ { "id": "NP_599246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599246", "type": "external" } ], "gene_names_uniprotkb": "Hspbap1; Pass1", "gene_names_refseq": "Hspbap1; Pass1", "protein_names_uniprotkb": "HSPB1-associated protein 1; 27 kDa heat shock protein-associated protein 1; Protein associated with small stress protein 1", "protein_names_refseq": "27 KdA heat shock protein-associated protein 1; HSPB1-associated protein 1; Hspb associated protein 1; protein associated with small stress protein 1; protein associating with small stress protein PASS1", "tax_id": 10116, "disease": "", "pathway": " (rno:171460)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10751411;29393594", "class_list": "", "function": "May play a role in cellular stress response., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R153", "ec_number_list": [], "go_molecular_function": "GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5BKC6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C1T0-1", "uniprot_id": [ { "id": "MMEL1_RAT", "url": "https://www.uniprot.org/uniprot/P0C1T0", "type": "external" } ], "mass": 89197.0, "length": 774, "protein_name": "Membrane metallo-endopeptidase-like 1", "gene_name": "Mmel1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mmel1; Mell1; Nep2", "gene_names_refseq": "", "protein_names_uniprotkb": "Membrane metallo-endopeptidase-like 1; 3.4.24.11; NEP2(m); NEP2(s); NEP2; NEPII; NL2; Neprilysin II; Neprilysin-2 secreted; Neprilysin-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:313755)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10814502;11964170;12710972;15294904;16081046", "class_list": "", "function": "Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P0C1T0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70132-1", "uniprot_id": [ { "id": "FEV_RAT", "url": "https://www.uniprot.org/uniprot/O70132", "type": "external" } ], "mass": 24991.0, "length": 237, "protein_name": "Protein FEV", "gene_name": "Fev", "organism": "Rat", "refseq_name": "protein FEV", "refseq_ac": [ { "id": "NP_653354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653354", "type": "external" } ], "gene_names_uniprotkb": "Fev; Pet1", "gene_names_refseq": "Fev; Pet1", "protein_names_uniprotkb": "Protein FEV; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1", "protein_names_refseq": "ETS domain transcription factor Pet-1; FEV (ETS oncogene family); FEV, ETS transcription factor; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; pet-1; protein FEV", "tax_id": 10116, "disease": "", "pathway": " (rno:246271)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10575032;19168037;9468386", "class_list": "", "function": "Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; We conclude that a physiologically relevant regimen of estradiol treatment in ovariectomized rats increases Pet-1 and 5-HTT mRNA levels in the midbrain raphe nuclei at a time when the anorexigenic effect of estradiol is apparent., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70132-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U309-1", "uniprot_id": [ { "id": "GT253_RAT", "url": "https://www.uniprot.org/uniprot/Q5U309", "type": "external" } ], "mass": 65223.0, "length": 572, "protein_name": "Probable inactive glycosyltransferase 25 family member 3", "gene_name": "Cercam", "organism": "Rat", "refseq_name": "probable inactive glycosyltransferase 25 family member 3 isoform X1", "refseq_ac": [ { "id": "XP_006233831", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006233831", "type": "external" } ], "gene_names_uniprotkb": "Cercam; Ceecam1; Glt25d3", "gene_names_refseq": "Ceecam1; Cercam", "protein_names_uniprotkb": "Probable inactive glycosyltransferase 25 family member 3; Cerebral endothelial cell adhesion molecule", "protein_names_refseq": "probable inactive glycosyltransferase 25 family member 3 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:296616)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U309-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50442-1", "uniprot_id": [ { "id": "GATM_RAT", "url": "https://www.uniprot.org/uniprot/P50442", "type": "external" } ], "mass": 48242.0, "length": 423, "protein_name": "Glycine amidinotransferase, mitochondrial", "gene_name": "Gatm", "organism": "Rat", "refseq_name": "glycine amidinotransferase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_112293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112293", "type": "external" } ], "gene_names_uniprotkb": "Gatm; Agat", "gene_names_refseq": "AT; Gatm", "protein_names_uniprotkb": "Glycine amidinotransferase, mitochondrial; 2.1.4.1; L-arginine:glycine amidinotransferase; Transamidinase", "protein_names_refseq": "L-arginine: glycine amidinotransferase; glycine amidinotransferase, mitochondrial precursor; glycine amidinotransferase, mitochondrial; l-arginine:glycine amidinotransferase; transamidinase", "tax_id": 10116, "disease": "AGAT deficiency (Disease Ontology:DOID:0050712); Fanconi renotubular syndrome 1 (Disease Ontology:DOID:0080757); pre-eclampsia (Disease Ontology:DOID:10591); acute kidney failure (Disease Ontology:DOID:3021); kidney disease (Disease Ontology:DOID:557); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:81660); (R-RNO-71288)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "11165387;15918910;19826191;3057136;3512696;6384218;6766137;8021264;8035648;9623603", "class_list": "", "function": "Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives (PubMed:6766137, PubMed:8035648). Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine (By similarity). Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (PubMed:6766137)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6ITZ7", "ec_number_list": [ { "id": "2.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.4.1", "type": "external" } ], "go_molecular_function": "GO:0015067 amidinotransferase activity;GO:0015068 glycine amidinotransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:1905395 response to flavonoid;GO:1990402 embryonic liver development;GO:0006979 response to oxidative stress;GO:0007584 response to nutrient;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P50442-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KMM4-1", "uniprot_id": [ { "id": "LX12B_RAT", "url": "https://www.uniprot.org/uniprot/Q2KMM4", "type": "external" } ], "mass": 80741.0, "length": 701, "protein_name": "Arachidonate 12-lipoxygenase, 12R-type", "gene_name": "Alox12b", "organism": "Rat", "refseq_name": "arachidonate 12-lipoxygenase, 12R-type", "refseq_ac": [ { "id": "NP_001034466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034466", "type": "external" } ], "gene_names_uniprotkb": "Alox12b", "gene_names_refseq": "Alox12b", "protein_names_uniprotkb": "Arachidonate 12-lipoxygenase, 12R-type; 1.13.11.-; 12R-LOX; 12R-lipoxygenase; Epidermis-type lipoxygenase 12", "protein_names_refseq": "12R-LOX; 12R-lipoxygenase; arachidonate 12-lipoxygenase, 12R-type; epidermis-type lipoxygenase 12", "tax_id": 10116, "disease": "autosomal recessive congenital ichthyosis 2 (Disease Ontology:DOID:0060710)", "pathway": " (rno:287425); (R-RNO-2142712)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15222128;19235890;23382512", "class_list": "", "function": "Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:23382512). In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins (By similarity)., [UniProtKB, UniProtKB, PubMed]; In summary, our data indicate that vitamin K prevents oxidative cell death by blocking activation of 12-LOX and ROS generation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KMM5", "ec_number_list": [ { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.31", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:1990136 linoleate 9S-lipoxygenase activity;GO:0047677 arachidonate 8(R)-lipoxygenase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0034440 lipid oxidation;GO:0010628 positive regulation of gene expression;GO:0043410 positive regulation of MAPK cascade;GO:0046513 ceramide biosynthetic process;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2KMM4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01812-1", "uniprot_id": [ { "id": "GRIK4_RAT", "url": "https://www.uniprot.org/uniprot/Q01812", "type": "external" } ], "mass": 107223.0, "length": 956, "protein_name": "Glutamate receptor ionotropic, kainate 4", "gene_name": "Grik4", "organism": "Rat", "refseq_name": "glutamate receptor ionotropic, kainate 4 precursor", "refseq_ac": [ { "id": "NP_036704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036704", "type": "external" } ], "gene_names_uniprotkb": "Grik4", "gene_names_refseq": "GluK4; Grik4; KA1", "protein_names_uniprotkb": "Glutamate receptor ionotropic, kainate 4; GluK4; Glutamate receptor KA-1; KA1", "protein_names_refseq": "glutamate receptor KA-1; glutamate receptor ionotropic, kainate 4 precursor; glutamate receptor ionotropic, kainate 4; kainate receceptor", "tax_id": 10116, "disease": "", "pathway": " (rno:24406); (R-RNO-451308)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1648176;19180187;20303934;25139762;27524200;9390526", "class_list": "", "function": "Adrenalectomy results in increased expression of hippocampal KA1 mRNA, an effect which is reversed by treatment with corticosterone..., [RefSeq, PubMed]; Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Cannot form functional channels on its own and shows channel activity only in heteromeric assembly with GRIK1, GRIK2 and GRIK3 subunits., [UniProtKB, PubMed, PubMed, PubMed]; Presynaptic kainate receptors on GABAergic nerve terminals appear to modulate GABAergic transmission, and in doing so may play an important role in the regulation of PAG neuron excitability., [RefSeq, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]; The structure of a high-affinity kainate receptor gluk4 ligand-binding domain crystallized with kainite has been presented., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q62642", "ec_number_list": [], "go_molecular_function": "GO:0004970 glutamate-gated receptor activity;GO:0015277 kainate selective glutamate receptor activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0008328 ionotropic glutamate receptor complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q01812-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI13-1", "uniprot_id": [ { "id": "GRWD1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI13", "type": "external" } ], "mass": 49169.0, "length": 445, "protein_name": "Glutamate-rich WD repeat-containing protein 1", "gene_name": "Grwd1", "organism": "Rat", "refseq_name": "glutamate-rich WD repeat-containing protein 1", "refseq_ac": [ { "id": "NP_001012067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012067", "type": "external" } ], "gene_names_uniprotkb": "Grwd1", "gene_names_refseq": "Grwd1", "protein_names_uniprotkb": "Glutamate-rich WD repeat-containing protein 1", "protein_names_refseq": "glutamate-rich WD repeat-containing protein 1", "tax_id": 10116, "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)", "pathway": " (rno:308592)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone binding protein that regulates chromatin dynamics and loading of minichromosome maintenance (MCM) complex at replication origins, possibly by promoting chromatin openness. Plays a role in ribosomal biogenesis., [UniProtKB, UniProtKB]; Histone binding-protein that regulates chromatin dynamics and loading of minichromosome maintenance (MCM) complex at replication origins, possibly by promoting chromatin openness. Plays a role in ribosomal biogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006260 DNA replication;GO:0042254 ribosome biogenesis;GO:0006334 nucleosome assembly;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI13-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R8C5-1", "uniprot_id": [ { "id": "M0R8C5_RAT", "url": "https://www.uniprot.org/uniprot/M0R8C5", "type": "external" } ], "mass": 39528.0, "length": 357, "protein_name": "ERI1 exoribonuclease family member 3", "gene_name": "Eri3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Eri3", "gene_names_refseq": "", "protein_names_uniprotkb": "ERI1 exoribonuclease family member 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0060906 negative regulation of regulatory ncRNA-mediated heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R8C5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LVW7-1", "uniprot_id": [ { "id": "DIAP3_RAT", "url": "https://www.uniprot.org/uniprot/F1LVW7", "type": "external" } ], "mass": 133833.0, "length": 1172, "protein_name": "Protein diaphanous homolog 3", "gene_name": "Diaph3", "organism": "Rat", "refseq_name": "protein diaphanous homolog 3", "refseq_ac": [ { "id": "NP_001292101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292101", "type": "external" } ], "gene_names_uniprotkb": "Diaph3", "gene_names_refseq": "DRF3; Diap3; Diaph3; mDIA2", "protein_names_uniprotkb": "Protein diaphanous homolog 3; DRF3; Diaphanous-related formin-3; mDIA2", "protein_names_refseq": "diaphanous homolog 3; protein diaphanous homolog 3", "tax_id": 10116, "disease": "autosomal dominant auditory neuropathy 1 (Disease Ontology:DOID:0060690); microcephaly (Disease Ontology:DOID:10907); congenital dyserythropoietic anemia (Disease Ontology:DOID:1338)", "pathway": " (rno:290396); (R-RNO-5663220); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013408); (R-RNO-9013423); (R-RNO-9035034)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "18651670;20624953", "class_list": "", "function": "Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity., [UniProtKB, UniProtKB]; Data suggest that genetic testing for DIAPH3 may be useful for individuals with recessive as well as dominant inheritance of nonsyndromic auditory neuropathy., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K8Y4", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0001701 in utero embryonic development;GO:0007015 actin filament organization;GO:0007059 chromosome segregation;GO:0007229 integrin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1LVW7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLL3-1", "uniprot_id": [ { "id": "LRC55_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLL3", "type": "external" } ], "mass": 33000.0, "length": 298, "protein_name": "Leucine-rich repeat-containing protein 55", "gene_name": "Lrrc55", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Lrrc55", "gene_names_refseq": "", "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 55; BK channel auxiliary gamma subunit LRRC55", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:311171)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity;GO:0099104 potassium channel activator activity", "go_cellular_component": "GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1903818 positive regulation of voltage-gated potassium channel activity;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLL3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85967-1", "uniprot_id": [ { "id": "GSDMC_RAT", "url": "https://www.uniprot.org/uniprot/P85967", "type": "external" } ], "mass": 53252.0, "length": 474, "protein_name": "Gasdermin-C", "gene_name": "Gsdmc", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gsdmc", "gene_names_refseq": "", "protein_names_uniprotkb": "Gasdermin-C", "protein_names_refseq": "", "tax_id": 10116, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (rno:299908)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pore-forming protein that causes membrane permeabilization and pyroptosis. Produced by the cleavage of gasdermin-C by caspase CASP8 in response to death signals. After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis., [UniProtKB, UniProtKB]; This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0001786 phosphatidylserine binding;GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042742 defense response to bacterium;GO:0070269 pyroptotic inflammatory response;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P85967-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88873-1", "uniprot_id": [ { "id": "GMEB2_RAT", "url": "https://www.uniprot.org/uniprot/O88873", "type": "external" } ], "mass": 56571.0, "length": 529, "protein_name": "Glucocorticoid modulatory element-binding protein 2", "gene_name": "Gmeb2", "organism": "Rat", "refseq_name": "glucocorticoid modulatory element-binding protein 2 isoform 1", "refseq_ac": [ { "id": "NP_113991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113991", "type": "external" } ], "gene_names_uniprotkb": "Gmeb2", "gene_names_refseq": "Gmeb2", "protein_names_uniprotkb": "Glucocorticoid modulatory element-binding protein 2; GMEB-2", "protein_names_refseq": "GMEB-2; glucocorticoid modulatory element-binding protein 2 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:83635)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10734202;7665613;9651376", "class_list": "", "function": "Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JL86;Q9JL87;Q9JL88;Q9QUZ7", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88873-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62882-1", "uniprot_id": [ { "id": "GNB5_RAT", "url": "https://www.uniprot.org/uniprot/P62882", "type": "external" } ], "mass": 38732.0, "length": 353, "protein_name": "Guanine nucleotide-binding protein subunit beta-5", "gene_name": "Gnb5", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein subunit beta-5", "refseq_ac": [ { "id": "NP_113958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113958", "type": "external" } ], "gene_names_uniprotkb": "Gnb5", "gene_names_refseq": "Gnb5", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit beta-5; Gbeta5; Transducin beta chain 5", "protein_names_refseq": "gbeta5; guanine nucleotide binding protein (G protein), beta 5; guanine nucleotide binding protein (G protein), beta polypeptide 5; guanine nucleotide binding protein, beta 5; guanine nucleotide-binding protein subunit beta-5; guanine nucleotide-binding protein, beta-5 subunit; transducin beta chain 5", "tax_id": 10116, "disease": "Lodder-Merla syndrome type 1 with impaired intellectual development and cardiac arrhythmia (Disease Ontology:DOID:0081008)", "pathway": " (rno:83579); (R-RNO-1296041); (R-RNO-202040); (R-RNO-2514859); (R-RNO-381676); (R-RNO-392170); (R-RNO-392451); (R-RNO-400042); (R-RNO-4086398); (R-RNO-416476); (R-RNO-418594); (R-RNO-418597); (R-RNO-420092); (R-RNO-428930); (R-RNO-432040); (R-RNO-456926); (R-RNO-6814122); (R-RNO-8964616); (R-RNO-9856530); (R-RNO-997272)", "pathway_count": 20, "publication_count": 1, "publication_id_list": "9622245", "class_list": "", "function": "Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation. Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition. Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors. May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O35354;P54314;Q5FWS8;Q91WB3", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0051087 protein-folding chaperone binding;GO:0032794 GTPase activating protein binding;GO:0030159 signaling receptor complex adaptor activity;GO:0031682 G-protein gamma-subunit binding", "go_cellular_component": "GO:0051286 cell tip;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007212 G protein-coupled dopamine receptor signaling pathway;GO:1990603 dark adaptation;GO:0036367 light adaption;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62882-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43245-1", "uniprot_id": [ { "id": "MDR1_RAT", "url": "https://www.uniprot.org/uniprot/P43245", "type": "external" } ], "mass": 141387.0, "length": 1277, "protein_name": "ATP-dependent translocase ABCB1", "gene_name": "Abcb1a; Abcb1b; Abcb1; Abcb4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Abcb1a; Abcb1b; Abcb1; Abcb4; Abcb1a; Abcb1b; Abcb1; Abcb4; Mdr1b; Mdr1; Pgy1", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent translocase ABCB1; 7.6.2.1; 7.6.2.2; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1", "protein_names_refseq": "", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); familial temporal lobe epilepsy 3 (Disease Ontology:DOID:0060750); progressive familial intrahepatic cholestasis 3 (Disease Ontology:DOID:0070223); intrahepatic cholestasis of pregnancy 3 (Disease Ontology:DOID:0070229); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); inflammatory bowel disease 13 (Disease Ontology:DOID:0110893); osteonecrosis (Disease Ontology:DOID:10159); antisocial personality disorder (Disease Ontology:DOID:10939); familial hyperlipidemia (Disease Ontology:DOID:1168); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); Behcet's disease (Disease Ontology:DOID:13241); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); intrahepatic cholestasis (Disease Ontology:DOID:1852); cholecystitis (Disease Ontology:DOID:1949); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); invasive ductal carcinoma (Disease Ontology:DOID:3008); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); toxic encephalopathy (Disease Ontology:DOID:3602); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); encephalitis (Disease Ontology:DOID:9588); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:170913); (R-RNO-382556); (R-RNO-9754706); (R-RNO-9757110)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "1348630;1682220;21454685;22673903", "class_list": "", "function": "Translocates phospholipids and drugs across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63426;Q63427", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" } ], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016324 apical plasma membrane;GO:0046581 intercellular canaliculus;GO:0098591 external side of apical plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0032496 response to lipopolysaccharide;GO:0001666 response to hypoxia;GO:0001894 tissue homeostasis;GO:0035640 exploration behavior", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P43245-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M868-1", "uniprot_id": [ { "id": "GBA2_RAT", "url": "https://www.uniprot.org/uniprot/Q5M868", "type": "external" } ], "mass": 102747.0, "length": 912, "protein_name": "Non-lysosomal glucosylceramidase", "gene_name": "Gba2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gba2", "gene_names_refseq": "", "protein_names_uniprotkb": "Non-lysosomal glucosylceramidase; 2.4.1.-; 3.2.1.-; 3.2.1.45; 3.2.1.46; Beta-glucocerebrosidase 2; Beta-glucosidase 2; Bile acid beta-glucosidase GBA2; Bile acid glucosyl transferase GBA2; Cholesterol glucosyltransferase GBA2; Cholesteryl-beta-glucosidase GBA2; Glucosylceramidase 2; NLGase; Non-lysosomal cholesterol glycosyltransferase; Non-lysosomal galactosylceramidase; Non-lysosomal glycosylceramidase", "protein_names_refseq": "", "tax_id": 10116, "disease": "hereditary spastic paraplegia 46 (Disease Ontology:DOID:0110798)", "pathway": " (rno:298399); (R-RNO-9840310)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide., [UniProtKB, UniProtKB]; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) to free glucose and ceramides (such as N-acylsphing-4-enine) (By similarity). GlcCers are membrane glycosphingolipids that have a wide intracellular distribution (By similarity). They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties (By similarity). Involved in the transglucosylation of cholesterol, transfers glucose from GlcCer to cholesterol, thereby modifying its water solubility and biological properties (By similarity). Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-3-beta-D-glucoside to ceramide (such as N-acylsphing-4-enine). May play a role in the metabolism of bile acids. Able to hydrolyze bile acid 3-O-glucosides as well as to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the galactosyl transfer between GalCers and cholesterol in vitro with lower activity compared with their activity against GlcCers (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45", "type": "external" }, { "id": "3.2.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.21", "type": "external" }, { "id": "3.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0008422 beta-glucosidase activity;GO:0046527 glucosyltransferase activity;GO:0004336 galactosylceramidase activity;GO:0050295 steryl-beta-glucosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006680 glucosylceramide catabolic process;GO:0008203 cholesterol metabolic process;GO:0005975 carbohydrate metabolic process;GO:0007417 central nervous system development;GO:0009247 glycolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M868-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000001000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82471-1", "uniprot_id": [ { "id": "GNAQ_RAT", "url": "https://www.uniprot.org/uniprot/P82471", "type": "external" } ], "mass": 42144.0, "length": 359, "protein_name": "Guanine nucleotide-binding protein G(q) subunit alpha", "gene_name": "Gnaq", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(q) subunit alpha", "refseq_ac": [ { "id": "NP_112298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112298", "type": "external" } ], "gene_names_uniprotkb": "Gnaq; ENSRNOG00000063937", "gene_names_refseq": "Galphaq; Gnaq", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(q) subunit alpha; 3.6.5.-; Guanine nucleotide-binding protein alpha-q", "protein_names_refseq": "guanine nucleotide binding protein (G protein), q polypeptide; guanine nucleotide binding protein alpha q subunit; guanine nucleotide binding protein, alpha q polypeptide; guanine nucleotide regulatory protein G alpha q; guanine nucleotide-binding protein G(q) subunit alpha; guanine nucleotide-binding protein alpha-q; heterotrimeric guanine nucleotide-binding protein alpha q subunit", "tax_id": 10116, "disease": "familial multiple nevi flammei (Disease Ontology:DOID:0111529); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); dilated cardiomyopathy (Disease Ontology:DOID:12930); McCune Albright syndrome (Disease Ontology:DOID:1858); lung non-small cell carcinoma (Disease Ontology:DOID:3908); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:81666); (R-RNO-112043); (R-RNO-202040); (R-RNO-399997); (R-RNO-416476); (R-RNO-418592); (R-RNO-428930); (R-RNO-434316); (R-RNO-456926); (R-RNO-9856530); (R-RNO-9860927)", "pathway_count": 11, "publication_count": 7, "publication_id_list": "1333286;18683930;27379421;31011763;31825720;32247043;32253686", "class_list": "", "function": "Enhanced activation of protein kinase C delta (PKCdelta) in vascular smooth muscle cell (VSMC) from hypertensive rats (SHR) increases the expression of G alpha protein q (Gqalpha) and phospholipase C beta1 (PLCbeta1) proteins and results in VSMC hypertrophy. Publication Status: Online-Only, [RefSeq, PubMed]; Galphaq-mediated calcium dynamics and membrane tension modulate neurite plasticity., [RefSeq, PubMed]; Gnaq Protects PC12 Cells from Oxidative Damage by Activation of Nrf2 and Inhibition of NF-kB., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, UniProtKB, UniProtKB]; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNAQ activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Required for platelet activation. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity). Together with GNA11, required for heart development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Mechanical Stretch Redefines Membrane Galphaq-Calcium Signaling Complexes., [RefSeq, PubMed]; The Galphaq/phospholipase Cbeta signaling system represses tau aggregation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0003924 GTPase activity;GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:1904888 cranial skeletal system development;GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:0086100 endothelin receptor signaling pathway;GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway;GO:0045634 regulation of melanocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P82471-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M854-1", "uniprot_id": [ { "id": "MGT4A_RAT", "url": "https://www.uniprot.org/uniprot/Q5M854", "type": "external" } ], "mass": 60590.0, "length": 526, "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "Mgat4a", "organism": "Rat", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2", "refseq_ac": [ { "id": "NP_001012225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012225", "type": "external" } ], "gene_names_uniprotkb": "Mgat4a", "gene_names_refseq": "Mgat4a", "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A; 2.4.1.145; GlcNAc-T IVa; GnT-IVa; N-acetylglucosaminyltransferase IVa; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa", "protein_names_refseq": "N-acetylglucosaminyltransferase IVa; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2; glcNAc-T IVa; gnT-IVa; mannoside acetylglucosaminyltransferase 4, isoenzyme A; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (rno:367252); (R-RNO-381426); (R-RNO-8957275); (R-RNO-975577)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "37962815", "class_list": "glycogene;glycosyltransferase", "function": "Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HCV affects KATP channels through GnT-IVa-mediated N-glycosylation of GLUT2 on the surface of pancreatic beta-cells leading to impaired insulin secretion., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0016757 glycosyltransferase activity;GO:0008453 alanine-glyoxylate transaminase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0005795 Golgi stack", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0046487 glyoxylate metabolic process;GO:0006487 protein N-linked glycosylation;GO:0006491 N-glycan processing", "synthesized_glycan_count": 3884, "hit_score": 0.2, "record_id": "Q5M854-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23785-1", "uniprot_id": [ { "id": "GRN_RAT", "url": "https://www.uniprot.org/uniprot/P23785", "type": "external" } ], "mass": 63370.0, "length": 588, "protein_name": "Progranulin", "gene_name": "Grn", "organism": "Rat", "refseq_name": "progranulin isoform a precursor", "refseq_ac": [ { "id": "NP_058809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058809", "type": "external" } ], "gene_names_uniprotkb": "Grn", "gene_names_refseq": "Grn; PEPI; PGRN", "protein_names_uniprotkb": "Progranulin; Acrogranin; Epithelin precursor; Epithelin-1; Epithelin-2; Granulin A; Granulin B; Granulin C; Granulin D; Granulin E; Granulin F; Granulin G; Granulin precursor; PEPI; PGRN; Proepithelin", "protein_names_refseq": "acrogranin; epithelin; granulins; proepithelin; progranulin isoform a precursor; progranulin; prostate cancer cell-derived growth factor", "tax_id": 10116, "disease": "primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); frontotemporal dementia 2 (Disease Ontology:DOID:0060672); neuronal ceroid lipofuscinosis 11 (Disease Ontology:DOID:0110732); Alzheimer's disease (Disease Ontology:DOID:10652); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); autistic disorder (Disease Ontology:DOID:12849); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); frontotemporal dementia (Disease Ontology:DOID:9255)", "pathway": " (rno:29143); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "1618805;2236009;2268320;28609022;29992506;31640144;39218796;8243292", "class_list": "", "function": "Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN., [RefSeq, PubMed]; PGRN is associated with intervertebral disc degeneration through interfering with IL-10 and IL-17, [RefSeq, PubMed]; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (By similarity). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (By similarity). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Sortilin is associated with progranulin deficiency and autism-like behaviors in valproic acid-induced autism rats., [RefSeq, PubMed]; Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study demonstrated that the level of PGRN protein in the cerebral cortex was significantly increased after microsphere-induced cerebral embolism (ME). Furthermore, PGRN was expressed in the microglia of the ipsilateral hemisphere after ME. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005768 endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0060179 male mating behavior;GO:1903979 negative regulation of microglial cell activation;GO:1903334 positive regulation of protein folding;GO:0002265 astrocyte activation involved in immune response", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P23785-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52KK4-1", "uniprot_id": [ { "id": "NAF1_RAT", "url": "https://www.uniprot.org/uniprot/Q52KK4", "type": "external" } ], "mass": 49764.0, "length": 457, "protein_name": "H/ACA ribonucleoprotein complex non-core subunit NAF1", "gene_name": "Naf1", "organism": "Rat", "refseq_name": "H/ACA ribonucleoprotein complex non-core subunit NAF1", "refseq_ac": [ { "id": "NP_001019943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019943", "type": "external" } ], "gene_names_uniprotkb": "Naf1", "gene_names_refseq": "Naf1; RGD1306802", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex non-core subunit NAF1", "protein_names_refseq": "H/ACA ribonucleoprotein complex non-core subunit NAF1; nuclear assembly factor 1 homolog", "tax_id": 10116, "disease": "melanoma (Disease Ontology:DOID:1909)", "pathway": " (rno:306387)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex", "go_biological_process": "GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0042254 ribosome biogenesis;GO:0006364 rRNA processing;GO:0001522 pseudouridine synthesis;GO:1904358 positive regulation of telomere maintenance via telomere lengthening", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q52KK4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0C3-1", "uniprot_id": [ { "id": "MCCA_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0C3", "type": "external" } ], "mass": 79330.0, "length": 715, "protein_name": "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "gene_name": "Mccc1", "organism": "Rat", "refseq_name": "methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial", "refseq_ac": [ { "id": "NP_001009653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009653", "type": "external" } ], "gene_names_uniprotkb": "Mccc1; Mcca", "gene_names_refseq": "Mccc1", "protein_names_uniprotkb": "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; 3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; 6.4.1.4; MCCase subunit alpha", "protein_names_refseq": "3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; MCCase subunit alpha; methylcrotonoyl-CoA carboxylase 1 (alpha); methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)", "tax_id": 10116, "disease": "3-methylcrotonyl-CoA carboxylase 1 deficiency (Disease Ontology:DOID:0080579)", "pathway": " (rno:294972); (R-RNO-196780); (R-RNO-70895)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "34502162", "class_list": "", "function": "Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004485 methylcrotonoyl-CoA carboxylase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1905202 methylcrotonoyl-CoA carboxylase complex", "go_biological_process": "GO:0006552 L-leucine catabolic process;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5I0C3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18298-1", "uniprot_id": [ { "id": "METK2_RAT", "url": "https://www.uniprot.org/uniprot/P18298", "type": "external" } ], "mass": 43716.0, "length": 395, "protein_name": "S-adenosylmethionine synthase isoform type-2", "gene_name": "Mat2al1; Mat2a", "organism": "Rat", "refseq_name": "S-adenosylmethionine synthase isoform type-2", "refseq_ac": [ { "id": "NP_599178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599178", "type": "external" } ], "gene_names_uniprotkb": "Mat2al1; Mat2a; Ams2; Mat2al1; RGD1560523", "gene_names_refseq": "Mat2a; Sams2", "protein_names_uniprotkb": "S-adenosylmethionine synthase isoform type-2; 2.5.1.6; AdoMet synthase 2; MAT 2; MAT-II; Methionine adenosyltransferase 2; Methionine adenosyltransferase II", "protein_names_refseq": "MAT 2; MAT-II; S-adenosylmethionine synthase isoform type-2; adoMet synthase 2; adoMet synthetase 2; methionine adenosyltransferase 2; methionine adenosyltransferase II, alpha; non-hepatic-type S-adenosylmethionine synthetase", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); lung cancer (Disease Ontology:DOID:1324); lipid metabolism disorder (Disease Ontology:DOID:3146); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:171347); (rno:498211); (R-RNO-156581)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15504733;1696256;19103603;33179842;34284075;36555116;9461287", "class_list": "", "function": "CBS and MAT2A improve methionine-mediated DNA synthesis through SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation., [RefSeq, PubMed]; Catalyzes the formation of S-adenosylmethionine from methionine and ATP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate., [UniProtKB, UniProtKB]; Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the miR-125a-5p/MAT2A Axis. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-26b-5p-modified hUB-MSCs derived exosomes attenuate early brain injury during subarachnoid hemorrhage via MAT2A-mediated the p38 MAPK/STAT3 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016597 amino acid binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005829 cytosol;GO:0048269 methionine adenosyltransferase complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0051291 protein heterooligomerization;GO:1990830 cellular response to leukemia inhibitory factor;GO:0007623 circadian rhythm;GO:0006730 one-carbon metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18298-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32301-1", "uniprot_id": [ { "id": "GLP1R_RAT", "url": "https://www.uniprot.org/uniprot/P32301", "type": "external" } ], "mass": 52877.0, "length": 463, "protein_name": "Glucagon-like peptide 1 receptor", "gene_name": "Glp1r", "organism": "Rat", "refseq_name": "glucagon-like peptide 1 receptor precursor", "refseq_ac": [ { "id": "NP_036860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036860", "type": "external" } ], "gene_names_uniprotkb": "Glp1r; Glpr", "gene_names_refseq": "Glip; Glp1r; RATGL1RCP", "protein_names_uniprotkb": "Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R", "protein_names_refseq": "GLP-1 receptor; GLP-1-R; GLP-1R; glucagon-like peptide 1 receptor precursor; pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); hyperglycemia (Disease Ontology:DOID:4195); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25051); (R-RNO-381676); (R-RNO-420092)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1326760;34713714;34943934;35618993;36599141;38069998;7527026;7813606", "class_list": "", "function": "G protein-coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:1326760, PubMed:7527026, PubMed:7813606). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:1326760, PubMed:7813606). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis. Erratum:[Cells. 2022 Nov 30;11(23):3838. doi: 10.3390/cells11233838. PMID: 36497203] Publication Status: Online-Only, [RefSeq, PubMed]; Glucagon-like peptide-1 receptor regulates receptor of advanced glycation end products in high glucose-treated rat mesangial cells., [RefSeq, PubMed]; Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation., [RefSeq, PubMed]; Role of Renal Sympathetic Nerves in GLP-1 (Glucagon-Like Peptide-1) Receptor Agonist Exendin-4-Mediated Diuresis and Natriuresis in Diet-Induced Obese Rats., [RefSeq, PubMed]; Sleeve Gastrectomy Improves High-Fat Diet-Associated Hepatic Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in Rats., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q64073;Q6LD83", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004967 glucagon receptor activity;GO:0044508 glucagon-like peptide 1 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P32301-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499Q5-1", "uniprot_id": [ { "id": "MKS1_RAT", "url": "https://www.uniprot.org/uniprot/Q499Q5", "type": "external" } ], "mass": 64523.0, "length": 561, "protein_name": "Tectonic-like complex member MKS1", "gene_name": "Mks1", "organism": "Rat", "refseq_name": "tectonic-like complex member MKS1", "refseq_ac": [ { "id": "NP_001030089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030089", "type": "external" } ], "gene_names_uniprotkb": "Mks1", "gene_names_refseq": "Mks1", "protein_names_uniprotkb": "Tectonic-like complex member MKS1; Meckel syndrome type 1 protein homolog", "protein_names_refseq": "Meckel syndrome, type 1; meckel syndrome type 1 protein homolog; tectonic-like complex member MKS1", "tax_id": 10116, "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 1 (Disease Ontology:DOID:0070115); Bardet-Biedl syndrome 13 (Disease Ontology:DOID:0110135); Joubert syndrome 28 (Disease Ontology:DOID:0110997); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (rno:287612); (R-RNO-5610787); (R-RNO-5620912)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19515853", "class_list": "", "function": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016020 membrane;GO:0005814 centriole;GO:0036038 MKS complex", "go_biological_process": "GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0001843 neural tube closure;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499Q5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54844-1", "uniprot_id": [ { "id": "MAF_RAT", "url": "https://www.uniprot.org/uniprot/P54844", "type": "external" } ], "mass": 38457.0, "length": 369, "protein_name": "Transcription factor Maf", "gene_name": "Maf", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Maf; Maf2", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor Maf; Proto-oncogene c-Maf; Transcription factor Maf-2; V-maf musculoaponeurotic fibrosarcoma oncogene homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "cataract 21 multiple types (Disease Ontology:DOID:0110256); Ayme-Gripp syndrome (Disease Ontology:DOID:0111688); cataract (Disease Ontology:DOID:83); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:54267)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "9038383;9375588", "class_list": "", "function": "Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T-helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0003690 double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P54844-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LVF4-1", "uniprot_id": [ { "id": "F1LVF4_RAT", "url": "https://www.uniprot.org/uniprot/F1LVF4", "type": "external" } ], "mass": 48705.0, "length": 442, "protein_name": "Protoheme IX farnesyltransferase, mitochondrial", "gene_name": "Cox10", "organism": "Rat", "refseq_name": "cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10", "refseq_ac": [ { "id": "NP_001385926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385926", "type": "external" } ], "gene_names_uniprotkb": "Cox10", "gene_names_refseq": "Cox10", "protein_names_uniprotkb": "Protoheme IX farnesyltransferase, mitochondrial; 2.5.1.-; Heme O synthase", "protein_names_refseq": "COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor; COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase; cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10; cytochrome c oxidase assembly homolog 10; protoheme IX farnesyltransferase, mitochondrial", "tax_id": 10116, "disease": "mitochondrial complex IV deficiency nuclear type 3 (Disease Ontology:DOID:0070492); Parkinson's disease (Disease Ontology:DOID:14330); Leigh disease (Disease Ontology:DOID:3652); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (R-RNO-189451)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Converts protoheme IX and farnesyl diphosphate to heme O., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0004311 geranylgeranyl diphosphate synthase activity;GO:0008495 protoheme IX farnesyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane;GO:0070069 cytochrome complex", "go_biological_process": "GO:0035264 multicellular organism growth;GO:0007005 mitochondrion organization;GO:0055070 copper ion homeostasis;GO:0000266 mitochondrial fission;GO:0017004 cytochrome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LVF4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LW67-1", "uniprot_id": [ { "id": "F1LW67_RAT", "url": "https://www.uniprot.org/uniprot/F1LW67", "type": "external" } ], "mass": 34811.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or2w6", "organism": "Rat", "refseq_name": "olfactory receptor Olr1657", "refseq_ac": [ { "id": "NP_001000536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000536", "type": "external" } ], "gene_names_uniprotkb": "Or2w6", "gene_names_refseq": "Olr1657; Or2w6; ratchr17-50548581-50547643_ORF", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1657; olfactory receptor Olr1657; olfactory receptor gene Olr1657; putative olfactory receptor 2W6", "tax_id": 10116, "disease": "", "pathway": " (rno:364726)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LW67-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LXS7-1", "uniprot_id": [ { "id": "LYSET_RAT", "url": "https://www.uniprot.org/uniprot/F1LXS7", "type": "external" } ], "mass": 18823.0, "length": 163, "protein_name": "Lysosomal enzyme trafficking factor", "gene_name": "Lyset", "organism": "Rat", "refseq_name": "lysosomal enzyme trafficking factor isoform 1", "refseq_ac": [ { "id": "NP_001385481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385481", "type": "external" } ], "gene_names_uniprotkb": "Lyset; Tmem251", "gene_names_refseq": "Lyset; RGD1566396; Tmem251", "protein_names_uniprotkb": "Lysosomal enzyme trafficking factor; Transmembrane protein 251", "protein_names_refseq": "lysosomal enzyme trafficking factor isoform 1; transmembrane protein 251", "tax_id": 10116, "disease": "mucolipidosis (Disease Ontology:DOID:0080488)", "pathway": " (rno:100360358)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36096887", "class_list": "", "function": "Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0031985 Golgi cisterna", "go_biological_process": "GO:0009615 response to virus;GO:0050790 regulation of catalytic activity;GO:0007040 lysosome organization;GO:0031647 regulation of protein stability;GO:0060627 regulation of vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1LXS7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LXU5-1", "uniprot_id": [ { "id": "F1LXU5_RAT", "url": "https://www.uniprot.org/uniprot/F1LXU5", "type": "external" } ], "mass": 43339.0, "length": 378, "protein_name": "Brachyury 2", "gene_name": "T2", "organism": "Rat", "refseq_name": "brachyury 2 isoform 1", "refseq_ac": [ { "id": "NP_001406442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406442", "type": "external" } ], "gene_names_uniprotkb": "T2", "gene_names_refseq": "T2", "protein_names_uniprotkb": "Brachyury 2", "protein_names_refseq": "brachyury 2 isoform 1", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LXU5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LYD3-1", "uniprot_id": [ { "id": "F1LYD3_RAT", "url": "https://www.uniprot.org/uniprot/F1LYD3", "type": "external" } ], "mass": 14736.0, "length": 140, "protein_name": "Transmembrane protein 210", "gene_name": "Tmem210", "organism": "Rat", "refseq_name": "transmembrane protein 210 precursor", "refseq_ac": [ { "id": "NP_001386629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386629", "type": "external" } ], "gene_names_uniprotkb": "Tmem210", "gene_names_refseq": "Tmem210", "protein_names_uniprotkb": "Transmembrane protein 210", "protein_names_refseq": "rCG45731-like; transmembrane protein 210 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:100362365)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0001669 acrosomal vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LYD3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54753-1", "uniprot_id": [ { "id": "H17B6_RAT", "url": "https://www.uniprot.org/uniprot/O54753", "type": "external" } ], "mass": 36145.0, "length": 317, "protein_name": "17-beta-hydroxysteroid dehydrogenase type 6", "gene_name": "ENSRNOG00000067654; Hsd17b6; LOC134479803", "organism": "Rat", "refseq_name": "17-beta-hydroxysteroid dehydrogenase type 6 isoform X2", "refseq_ac": [ { "id": "XP_017450177", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017450177", "type": "external" } ], "gene_names_uniprotkb": "ENSRNOG00000067654; Hsd17b6; LOC134479803; Hsd17b6; Hsd17b9; LOC100362350; LOC134479803", "gene_names_refseq": "Hsd17b6; Hsd17b9", "protein_names_uniprotkb": "17-beta-hydroxysteroid dehydrogenase type 6; 1.1.1.105; 1.1.1.209; 1.1.1.239; 1.1.1.53; 1.1.1.62; 17-beta-HSD 6; 17-beta-HSD6; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; Oxidative 3-alpha hydroxysteroid dehydrogenase", "protein_names_refseq": "17-beta-hydroxysteroid dehydrogenase type 6 isoform X2", "tax_id": 10116, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (rno:286964)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9188497", "class_list": "", "function": "NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro) (By similarity). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). 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"url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0047035 testosterone dehydrogenase (NAD+) activity;GO:0047045 testosterone dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0008209 androgen metabolic process;GO:0008202 steroid metabolic process;GO:0062175 brexanolone catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O54753-1", "record_type": "protein", "filter_code": 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"2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity;GO:0000287 magnesium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0032991 protein-containing complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0006468 protein phosphorylation;GO:0006974 DNA damage response;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1LYY7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M1L9-1", "uniprot_id": [ { "id": "F1M1L9_RAT", "url": "https://www.uniprot.org/uniprot/F1M1L9", "type": "external" } ], "mass": 61122.0, "length": 548, "protein_name": "Copine-2", "gene_name": "Cpne2", "organism": "Rat", "refseq_name": "copine-2", "refseq_ac": [ { "id": "NP_001243395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243395", "type": "external" } ], "gene_names_uniprotkb": "Cpne2; LOC498972", "gene_names_refseq": "Cpne2", "protein_names_uniprotkb": "Copine-2; Copine II", "protein_names_refseq": "copine II; copine-2", "tax_id": 10116, "disease": "", "pathway": " (rno:498972)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "H1UBM7", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M1L9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M5F3-1", "uniprot_id": [ { "id": "MCM9_RAT", "url": "https://www.uniprot.org/uniprot/F1M5F3", "type": "external" } ], "mass": 124125.0, "length": 1124, "protein_name": "DNA helicase MCM9", "gene_name": "Mcm9", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mcm9; Mcmdc1; RGD1560557", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA helicase MCM9; 5.6.2.4; DNA 3'-5' helicase MCM9; Mini-chromosome maintenance deficient domain-containing protein 1; Minichromosome maintenance 9", "protein_names_refseq": "", "tax_id": 10116, "disease": "ovarian dysgenesis 4 (Disease Ontology:DOID:0080496); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:499437)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0097362 MCM8-MCM9 complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination;GO:0007292 female gamete generation;GO:0071168 protein localization to chromatin;GO:0007276 gamete generation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M5F3-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22199-1", "uniprot_id": [ { "id": "MCR_RAT", "url": "https://www.uniprot.org/uniprot/P22199", "type": "external" } ], "mass": 106737.0, "length": 981, "protein_name": "Mineralocorticoid receptor", "gene_name": "Nr3c2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nr3c2; Mlr", "gene_names_refseq": "", "protein_names_uniprotkb": "Mineralocorticoid receptor; MR; Nuclear receptor subfamily 3 group C member 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant pseudohypoaldosteronism type 1 (Disease Ontology:DOID:0060855); opioid abuse (Disease Ontology:DOID:11206); polycystic ovary syndrome (Disease Ontology:DOID:11612); Down syndrome (Disease Ontology:DOID:14250); alcohol use disorder (Disease Ontology:DOID:1574); morphine dependence (Disease Ontology:DOID:2560); pseudohypoaldosteronism (Disease Ontology:DOID:4479); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25672); (R-RNO-3371497); (R-RNO-383280); (R-RNO-4090294)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "10687858;15240697;22673903;2558305;7495694;7982810;8618925;9111344;9677313", "class_list": "", "function": "Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63763;Q64174", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003707 nuclear steroid receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0098831 presynaptic active zone cytoplasmic component;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0097305 response to alcohol;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0007626 locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P22199-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M775-1", "uniprot_id": [ { "id": "DIAP1_RAT", "url": "https://www.uniprot.org/uniprot/F1M775", "type": "external" } ], "mass": 140410.0, "length": 1265, "protein_name": "Protein diaphanous homolog 1", "gene_name": "Diaph1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Diaph1; Diap1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein diaphanous homolog 1; DRF1; Diaphanous-related formin-1; mDIA1", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant auditory neuropathy 1 (Disease Ontology:DOID:0060690); autosomal dominant nonsyndromic deafness 1 (Disease Ontology:DOID:0110541); sensorineural hearing loss (Disease Ontology:DOID:10003); microcephaly (Disease Ontology:DOID:10907)", "pathway": " (rno:307483); (R-RNO-5663220); (R-RNO-6785631); (R-RNO-6798695); (R-RNO-8980692); (R-RNO-9013026); (R-RNO-9013106); (R-RNO-9035034)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "18651670", "class_list": "", "function": "Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0044325 transmembrane transporter binding;GO:0031267 small GTPase binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005884 actin filament;GO:0005903 brush border", "go_biological_process": "GO:0016199 axon midline choice point recognition;GO:0030335 positive regulation of cell migration;GO:0031175 neuron projection development;GO:0048013 ephrin receptor signaling pathway;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1M775-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49864-1", "uniprot_id": [ { "id": "GRAK_RAT", "url": "https://www.uniprot.org/uniprot/P49864", "type": "external" } ], "mass": 28465.0, "length": 258, "protein_name": "Granzyme K", "gene_name": "Gzmk", "organism": "Rat", "refseq_name": "granzyme K precursor", "refseq_ac": [ { "id": "NP_058815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058815", "type": "external" } ], "gene_names_uniprotkb": "Gzmk", "gene_names_refseq": "Gzmk", "protein_names_uniprotkb": "Granzyme K; 3.4.21.-; NK-Tryp-2; NK-tryptase-2", "protein_names_refseq": "NK-Tryp-2; NK-tryptase-2; RNK-Tryp-2; granzyme K precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:29165)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8133042", "class_list": "", "function": "Serine protease that initiates the GZMK pathway of the complement system, a cascade of proteins directly activated by CD8(+) T-cells that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. GZMK is specifically secreted by CD8(+) T-cells and mediates both recognition and initiation steps of GZMK complement pathway. First acts as a pattern recognition receptor, which specifically recognizes and binds heparan sulfate glycosaminoglycans on the pathogen surface to drive opsonization. It then initiates the complement pathway cascade by catalyzing cleavage and activation of C2 and C4, the next components of the complement pathway. GZMK-mediated complement activation is an important contributor to tissue inflammation. Also able to cleave and activate F2R/PAR1 and PAR2/F2RL1, possibly promoting interleukin release. May also regulate apoptosis by catalyzing cleavage and activation of BID, thereby promoting cytochrome C release from mitochrondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005539 glycosaminoglycan binding;GO:0038187 pattern recognition receptor activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0006954 inflammatory response;GO:0050729 positive regulation of inflammatory response;GO:0090200 positive regulation of release of cytochrome c from mitochondria;GO:0051604 protein maturation;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49864-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19218-1", "uniprot_id": [ { "id": "GP2_RAT", "url": "https://www.uniprot.org/uniprot/P19218", "type": "external" } ], "mass": 58708.0, "length": 530, "protein_name": "Pancreatic secretory granule membrane major glycoprotein GP2", "gene_name": "Gp2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Pancreatic secretory granule membrane major glycoprotein GP2; Glycoprotein 80; Pancreatic zymogen granule membrane protein GP-2; gp80", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-163125)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11853552;1999417;2216794;6479170;8352773", "class_list": "", "function": "Functions as an intestinal M-cell transcytotic receptor specific of type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response., [UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003823 antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0002412 antigen transcytosis by M cells in mucosal-associated lymphoid tissue;GO:1990266 neutrophil migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P19218-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MA46-1", "uniprot_id": [ { "id": "F1MA46_RAT", "url": "https://www.uniprot.org/uniprot/F1MA46", "type": "external" } ], "mass": 128065.0, "length": 1180, "protein_name": "Protocadherin-12", "gene_name": "Pcdh12", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pcdh12", "gene_names_refseq": "", "protein_names_uniprotkb": "Protocadherin-12; Vascular cadherin-2; Vascular endothelial cadherin-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Acts as a regulator of cell migration, probably via increasing cell-cell adhesion. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0007283 spermatogenesis;GO:0005977 glycogen metabolic process;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0060711 labyrinthine layer development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MA46-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MAG1-1", "uniprot_id": [ { "id": "F1MAG1_RAT", "url": "https://www.uniprot.org/uniprot/F1MAG1", "type": "external" } ], "mass": 14222.0, "length": 129, "protein_name": "Agouti-related protein", "gene_name": "Agrp", "organism": "Rat", "refseq_name": "agouti-related protein precursor", "refseq_ac": [ { "id": "NP_387499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_387499", "type": "external" } ], "gene_names_uniprotkb": "Agrp", "gene_names_refseq": "Agrp", "protein_names_uniprotkb": "Agouti-related protein", "protein_names_refseq": "agouti-related protein precursor", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25582)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22715380;25509169;26907996;36817590", "class_list": "", "function": "Compared to the rats in the control group, the rats in the HF group had the expression levels of 12 genes with significant changes, Agrp, Ghrl, and Nr3c1, Apoa4, Cntf, Ghr, IL-1beta, Ins1, Lepr,Sort, Adcyap1r1 and Adrb1., [RefSeq, PubMed]; Dieting reverses histone methylation and hypothalamic AgRP regulation in obese rats. Publication Status: Online-Only, [RefSeq, PubMed]; Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptors MC3R and MC4R by precluding agonist-induced signaling, thereby inhibiting cAMP production within the hypothalamus and adrenal gland. Involved in the control of feeding behavior via the central melanocortin system. Has very low activity towards MC5R. Also promotes endocytosis of MC3R and MC4R in an arrestin-dependent mechanism., [UniProtKB, UniProtKB]; Study suggests that passive PNS rats have innate impairments in leptin and ghrelin responses to starvation combined with prenatal stress associated impairments in Agrp and orexin expression in response to starvation., [RefSeq, PubMed]; The obtained data demonstrate the role ofAGRP as a modulator of the functional activity of the dopaminergic brain neurons., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048019 receptor antagonist activity;GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0070996 type 1 melanocortin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0043025 neuronal cell body", "go_biological_process": "GO:0032100 positive regulation of appetite;GO:1904000 positive regulation of eating behavior;GO:0007218 neuropeptide signaling pathway;GO:0042755 eating behavior;GO:0060135 maternal process involved in female pregnancy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1MAG1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z3T4-1", "uniprot_id": [ { "id": "MBNL2_RAT", "url": "https://www.uniprot.org/uniprot/F2Z3T4", "type": "external" } ], "mass": 40156.0, "length": 373, "protein_name": "Muscleblind-like protein 2", "gene_name": "Mbnl2", "organism": "Rat", "refseq_name": "muscleblind-like protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001104534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104534", "type": "external" } ], "gene_names_uniprotkb": "Mbnl2", "gene_names_refseq": "Mbnl2", "protein_names_uniprotkb": "Muscleblind-like protein 2", "protein_names_refseq": "muscleblind-like 2; muscleblind-like protein 2 isoform 1; muscleblind-like protein 2", "tax_id": 10116, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonic disease (Disease Ontology:DOID:450)", "pathway": " (rno:680445)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19457059;31283468;37548402", "class_list": "", "function": "Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (PubMed:37548402). Regulates NCOR2 alternative splicing (PubMed:31283468). Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity)., [UniProtKB, PubMed, PubMed]; Pineal Mbnl2 transcripts and protein levels exhibit marked circadian rhythms; both are neurally regulated by an adrenergic/cyclic adenosine monophosphate (cAMP) mechanism. GeneRIF: Mbnl2 is strongly expressed in the rat pineal gland. Mbnl2 mRNA and protein exhibit a circadian rhythm with ~ sevenfold higher values at night than day levels. Mbnl2 mRNA and protein levels are controlled by an adrenergic/cAMP mechanism., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F2Z3T4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7FEH8-1", "uniprot_id": [ { "id": "F7FEH8_RAT", "url": "https://www.uniprot.org/uniprot/F7FEH8", "type": "external" } ], "mass": 7291.0, "length": 63, "protein_name": "Defensin beta 37", "gene_name": "Defb37", "organism": "Rat", "refseq_name": "beta-defensin 37 precursor", "refseq_ac": [ { "id": "NP_001398743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001398743", "type": "external" } ], "gene_names_uniprotkb": "Defb37", "gene_names_refseq": "Defb37", "protein_names_uniprotkb": "Defensin beta 37", "protein_names_refseq": "beta-defensin 37 precursor; beta-defensin 37-like; beta-defensin 37", "tax_id": 10116, "disease": "", "pathway": " (rno:652921)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7FEH8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7FNG0-1", "uniprot_id": [ { "id": "F7FNG0_RAT", "url": "https://www.uniprot.org/uniprot/F7FNG0", "type": "external" } ], "mass": 27884.0, "length": 256, "protein_name": "Proteinase 3", "gene_name": "Prtn3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prtn3", "gene_names_refseq": "", "protein_names_uniprotkb": "Proteinase 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-6798695); (R-RNO-6803157); (R-RNO-9769739)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0044853 plasma membrane raft;GO:0035578 azurophil granule lumen;GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis;GO:0043547 positive regulation of GTPase activity;GO:0050765 negative regulation of phagocytosis;GO:0097029 mature conventional dendritic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7FNG0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70618-1", "uniprot_id": [ { "id": "MK14_RAT", "url": "https://www.uniprot.org/uniprot/P70618", "type": "external" } ], "mass": 41321.0, "length": 360, "protein_name": "Mitogen-activated protein kinase 14", "gene_name": "Mapk14", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Mapk14; Csbp1; Csbp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase 14; 2.7.11.24; CRK1; MAP kinase 14; MAP kinase p38 alpha; MAPK 14; Mitogen-activated protein kinase p38 alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); interstitial cystitis (Disease Ontology:DOID:13949); Parkinson's disease (Disease Ontology:DOID:14330); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219); gastric adenocarcinoma (Disease Ontology:DOID:3717); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (R-RNO-168638); (R-RNO-171007); (R-RNO-198753); (R-RNO-2559580); (R-RNO-418592); (R-RNO-432142); (R-RNO-4420097); (R-RNO-450302); (R-RNO-450341); (R-RNO-525793); (R-RNO-5668599); (R-RNO-6798695); (R-RNO-6804756); (R-RNO-69601)", "pathway_count": 14, "publication_count": 6, "publication_id_list": "12452429;20626350;22673903;23312093;36642184;9513091", "class_list": "", "function": "Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 also interacts with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Phosphorylates S100A9 at 'Thr-113' (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, 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"5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0051525 NFAT protein binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0042307 positive regulation of protein import into nucleus;GO:0030316 osteoclast differentiation;GO:0071493 cellular response to UV-B;GO:0090400 stress-induced premature senescence", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P70618-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14095-1", "uniprot_id": [ { "id": "GROA_RAT", "url": "https://www.uniprot.org/uniprot/P14095", "type": "external" } ], "mass": 10249.0, "length": 96, "protein_name": "Growth-regulated alpha protein", "gene_name": "Cxcl1", "organism": "Rat", "refseq_name": "growth-regulated alpha protein precursor", "refseq_ac": [ { "id": "NP_110472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110472", "type": "external" } ], "gene_names_uniprotkb": "Cxcl1; Cinc1; Gro; Scyb1", "gene_names_refseq": "CINC-1; Cxcl1; Gro1", "protein_names_uniprotkb": "Growth-regulated alpha protein; C-X-C motif chemokine 1; CINC-1; Cytokine-induced neutrophil chemoattractant 1; Platelet-derived growth factor-inducible protein KC", "protein_names_refseq": "C-X-C motif chemokine 1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); cytokine-induced neutrophil chemoattractant 1; growth-regulated alpha protein precursor; growth-regulated alpha protein; platelet-derived growth factor-inducible protein KC", "tax_id": 10116, "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); stroke (Disease Ontology:DOID:0051061); alcohol-associated liver disease (Disease Ontology:DOID:0070658); COVID-19 (Disease Ontology:DOID:0080600); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); common cold (Disease Ontology:DOID:10459); viral pneumonia (Disease Ontology:DOID:10533); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); dilated cardiomyopathy (Disease Ontology:DOID:12930); interstitial cystitis (Disease Ontology:DOID:13949); prostatitis (Disease Ontology:DOID:14654); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); esophageal cancer (Disease Ontology:DOID:5041); pneumonia (Disease Ontology:DOID:552); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (rno:81503); (R-RNO-380108); (R-RNO-418594); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "1374243;1415488;2684956;33867350;7957925;8482545;8607872;9192722;9504410", "class_list": "", "function": "Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation., [UniProtKB]; MicroRNA-532-5p protects against cerebral ischemia-reperfusion injury by directly targeting CXCL1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010332 response to gamma radiation;GO:0032496 response to lipopolysaccharide;GO:0032930 positive regulation of superoxide anion generation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P14095-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97700-1", "uniprot_id": [ { "id": "M2OM_RAT", "url": "https://www.uniprot.org/uniprot/P97700", "type": "external" } ], "mass": 34244.0, "length": 314, "protein_name": "Mitochondrial 2-oxoglutarate/malate carrier protein", "gene_name": "Slc25a11", "organism": "Rat", "refseq_name": "mitochondrial 2-oxoglutarate/malate carrier protein", "refseq_ac": [ { "id": "NP_071793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071793", "type": "external" } ], "gene_names_uniprotkb": "Slc25a11; Slc20a4", "gene_names_refseq": "Slc25a11", "protein_names_uniprotkb": "Mitochondrial 2-oxoglutarate/malate carrier protein; Alpha-oxoglutarate carrier; OGCP; SLC25A11; Solute carrier family 25 member 11", "protein_names_refseq": "2-oxoglutarate carrier; OGCP; alpha-oxoglutarate carrier; mitochondrial 2-oxoglutarate/malate carrier protein; oxoglutarate carrier), member 11; solute carrier family 25 (mitochondrial carrier", "tax_id": 10116, "disease": "pheochromocytoma/paraganglioma syndrome 6 (Disease Ontology:DOID:0061221)", "pathway": " (rno:64201); (R-RNO-428643); (R-RNO-9856872)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "12939596;16291728;16920706;20356834;22115789;22673903;24606213;26446791;27213235;28100784;3355813;34502162;38843836;5083502;7703504", "class_list": "", "function": "Bcl-2 and 2-oxoglutarate carrier appear to act in a coordinated manner to increase the mitochondrial glutathione pool and enhance resistance of cells to oxidative stress, [RefSeq, PubMed]; Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed:3355813, PubMed:5083502, PubMed:7703504, PubMed:16291728). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (PubMed:3355813, PubMed:7703504). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). Does not transport glutathione (By similarity). In addition can facilitate proton transport in the presence of protonophores such as long-chain fatty acids, contributing to mitochondrial uncoupling and regulation of mitochondrial energetic efficiency (By similarity). Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism (PubMed:3355813, PubMed:5083502). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis (PubMed:16291728)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data provide evidence for a role of the 2-oxoglutarate carrier as a glutathione transporting polypeptide, [RefSeq, PubMed]; Oxoglutarate carrier works in a concerted manner to maintain the mitochondrial glutathione pool which is crucial for neuronal survival., [RefSeq, PubMed]; Porphyrin accumulation in mitochondria is mediated by OGC and porphyrins are able to competitively inhibit 2-oxoglutarate uptake into mitochondria, [RefSeq, PubMed]; The OGC is part of a mechanism of fuel-stimulated insulin secretion that is common to glucose, amino acid, and organic acid secretagogues, involving flux through the pyruvate/isocitrate cycling pathway, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015367 oxoglutarate:malate antiporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0043490 malate-aspartate shuttle;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P97700-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39020-1", "uniprot_id": [ { "id": "MEOX2_RAT", "url": "https://www.uniprot.org/uniprot/P39020", "type": "external" } ], "mass": 33605.0, "length": 303, "protein_name": "Homeobox protein MOX-2", "gene_name": "Meox2", "organism": "Rat", "refseq_name": "homeobox protein MOX-2", "refseq_ac": [ { "id": "NP_058845", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058845", "type": "external" } ], "gene_names_uniprotkb": "Meox2; Gax; Mox-2; Mox2", "gene_names_refseq": "Meox2", "protein_names_uniprotkb": "Homeobox protein MOX-2; Growth arrest-specific homeobox; Mesenchyme homeobox 2", "protein_names_refseq": "growth arrest-specific homeobox; homeobox protein MOX-2; mesenchyme homeo box 2 (growth arrest-specific homeo box)", "tax_id": 10116, "disease": "myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:29279)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15680482;24155330;25280940;36713029;8098844", "class_list": "", "function": "Demonstrated that Ang II down-regulated Gax expression via redox-sensitive ERK1/2 activation in vascular smooth muscle cells [Gax], [RefSeq, PubMed]; Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation. Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (PubMed:8098844). Also acts as a negative regulator of angiogenesis. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (By similarity). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Ski modulates the cardiac myofibroblast phenotype and function through suppression of Zeb2 by upregulating the expression of Meox2., [RefSeq, PubMed]; The present study was designed to investigate whether FAK/Pyk2 and ERK1/2 MAPK signaling pathways participate in Perivascular adipocyte functions, which is activated by insulin-like growth factor 1(IGF-1) and inhibited by Gax., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P39020-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54947-1", "uniprot_id": [ { "id": "HAVR1_RAT", "url": "https://www.uniprot.org/uniprot/O54947", "type": "external" } ], "mass": 33964.0, "length": 307, "protein_name": "Hepatitis A virus cellular receptor 1 homolog", "gene_name": "Havcr1", "organism": "Rat", "refseq_name": "hepatitis A virus cellular receptor 1 homolog precursor", "refseq_ac": [ { "id": "NP_775172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775172", "type": "external" } ], "gene_names_uniprotkb": "Havcr1; Kim1", "gene_names_refseq": "Havcr1; KIM-1; Kim1", "protein_names_uniprotkb": "Hepatitis A virus cellular receptor 1 homolog; HAVcr-1; KIM-1; Kidney injury molecule 1; T cell immunoglobulin and mucin domain-containing protein 1; TIMD-1", "protein_names_refseq": "HAVcr-1; TIMD-1; hepatitis A virus cellular receptor 1 homolog precursor; hepatitis A virus cellular receptor 1 homolog; kidney injury molecule 1; t cell immunoglobulin and mucin domain-containing protein 1", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); hydronephrosis (Disease Ontology:DOID:11111); acute kidney tubular necrosis (Disease Ontology:DOID:12556); renovascular hypertension (Disease Ontology:DOID:1591); hyperuricemia (Disease Ontology:DOID:1920); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); atopic dermatitis (Disease Ontology:DOID:3310); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic kidney disease (Disease Ontology:DOID:784); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (rno:286934)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18414680;33678127;36598304;36934678;9461608", "class_list": "", "function": "Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression., [RefSeq, PubMed]; Kidney injury molecule-1 and podocalyxin dysregulation in an arginine vasopressin induced rodent model of preeclampsia., [RefSeq, PubMed]; Malate reduced kidney injury molecule (KIM-1) expression and selectively upregulated the renal nitric oxide production in obstructive nephropathy., [RefSeq, PubMed]; Phosphatidylserine receptor that plays an important functional role in regulatory B-cell homeostasis including generation, expansion and suppressor functions (By similarity). Involved in efferocytosis, the process by which apoptotic cells are removed, by binding to phosphatidylserine present on apoptotic cells and promoting their engulfment (By similarity). Confers phagocytic ability on injured kidney epithelial cells, allowing them to bind to and internalize apoptotic bodies and necrotic debris following kidney injury (PubMed:18414680). The ectodomain binds to the surface of apoptotic kidney epithelial cells via phosphatidylserine and oxidized phospholipids exposed on the cell membrane of the apoptotic cells (By similarity). HAVCR1-expressing cells are also capable of phagocytosing Gram-negative and Gram-positive bacteria (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (By similarity). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (By similarity). Acts as a regulator of T-cell proliferation. Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001618 virus receptor activity;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005615 extracellular space;GO:0005903 brush border;GO:0009986 cell surface;GO:0031514 motile cilium", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0007584 response to nutrient;GO:0032496 response to lipopolysaccharide;GO:0009611 response to wounding;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54947-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V777-1", "uniprot_id": [ { "id": "G3V777_RAT", "url": "https://www.uniprot.org/uniprot/G3V777", "type": "external" } ], "mass": 76900.0, "length": 683, "protein_name": "Zinc finger and BTB domain-containing protein 48", "gene_name": "Zbtb48", "organism": "Rat", "refseq_name": "telomere zinc finger-associated protein", "refseq_ac": [ { "id": "NP_001013234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013234", "type": "external" } ], "gene_names_uniprotkb": "Zbtb48", "gene_names_refseq": "Hkr3; Zbtb48", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 48; Telomere zinc finger-associated protein", "protein_names_refseq": "GLI-Kruppel family member HKR3; telomere zinc finger-associated protein; zinc finger and BTB domain-containing protein 48", "tax_id": 10116, "disease": "", "pathway": " (rno:362668)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A. Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression. In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region;GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0051252 regulation of RNA metabolic process;GO:0010833 telomere maintenance via telomere lengthening;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V777-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V783-1", "uniprot_id": [ { "id": "G3V783_RAT", "url": "https://www.uniprot.org/uniprot/G3V783", "type": "external" } ], "mass": 60777.0, "length": 539, "protein_name": "Receptor-interacting serine/threonine-protein kinase 2", "gene_name": "Ripk2", "organism": "Rat", "refseq_name": "receptor-interacting serine/threonine-protein kinase 2", "refseq_ac": [ { "id": "NP_001178794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178794", "type": "external" } ], "gene_names_uniprotkb": "Ripk2", "gene_names_refseq": "Ripk2", "protein_names_uniprotkb": "Receptor-interacting serine/threonine-protein kinase 2; 2.7.10.2; 2.7.11.1; Tyrosine-protein kinase RIPK2", "protein_names_refseq": "receptor (TNFRSF)-interacting serine-threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:362491); (R-RNO-168638); (R-RNO-202424); (R-RNO-209543); (R-RNO-450302); (R-RNO-450321); (R-RNO-5689896)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "22673903;26138652;27169686;30352081;37128885;38064597", "class_list": "", "function": "Blocking RIPK2 Function Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating the AKT and NF-kappaB Pathways., [RefSeq, PubMed]; Combined results support the hypothesis that high glucose and LPS can activate the NOD1-RICK-NF-kappaB inflammatory signaling pathway via the NOD1 receptor, and may participate in the development of diabetic nephropathy., [RefSeq, PubMed]; LACC1 Promoted Nerve Injury in an Anesthesia-Induced Cognitive Disorder Model via RIP2 Expression through ROS-NOD2 Induction., [RefSeq, PubMed]; Nod2-Rip2-NFkappaB signaling involved in the small intestinal inflammatory injury caused by muramyl dipeptide which is transported through PepT1., [RefSeq, PubMed]; Receptor-interacting serine-threonine kinase 2 (RIP2) tends to form high-order oligomers at physiological pH while being monomeric under acidic conditions. Publication Status: Online-Only, [RefSeq, PubMed]; Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "G3V783-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07152-1", "uniprot_id": [ { "id": "MMP10_RAT", "url": "https://www.uniprot.org/uniprot/P07152", "type": "external" } ], "mass": 54222.0, "length": 476, "protein_name": "Stromelysin-2", "gene_name": "Mmp10", "organism": "Rat", "refseq_name": "stromelysin-2 precursor", "refseq_ac": [ { "id": "NP_598198", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598198", "type": "external" } ], "gene_names_uniprotkb": "Mmp10", "gene_names_refseq": "Mmp10; SL-2", "protein_names_uniprotkb": "Stromelysin-2; 3.4.24.22; MMP-10; Matrix metalloproteinase-10; SL-2; Transformation-associated protein 34A; Transin-2", "protein_names_refseq": "matrix metalloproteinase-10; stromelysin-2 precursor; stromelysin-2; transformation-associated protein 34A; transin-2", "tax_id": 10116, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588); end stage renal disease (Disease Ontology:DOID:783); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:117061); (R-RNO-1442490); (R-RNO-1474228); (R-RNO-1592389)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "1370458;24339723;31428857;3547333", "class_list": "", "function": "Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase., [UniProtKB]; Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression., [RefSeq, PubMed]; MMP-10 modulates corneal epithelial wound healing. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.24.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.24.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22", "type": "external" }, { "id": "3.4.21.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.24.65", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030334 regulation of cell migration;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P07152-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30553-1", "uniprot_id": [ { "id": "GASR_RAT", "url": "https://www.uniprot.org/uniprot/P30553", "type": "external" } ], "mass": 48957.0, "length": 452, "protein_name": "Gastrin/cholecystokinin type B receptor", "gene_name": "Cckbr", "organism": "Rat", "refseq_name": "gastrin/cholecystokinin type B receptor", "refseq_ac": [ { "id": "NP_037297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037297", "type": "external" } ], "gene_names_uniprotkb": "Cckbr", "gene_names_refseq": "Cck2r; Cckbr; Cholrec", "protein_names_uniprotkb": "Gastrin/cholecystokinin type B receptor; CCK-B receptor; CCK-BR; CCK2-R; Cholecystokinin-2 receptor", "protein_names_refseq": "CCK-B receptor; CCK-BR; CCK2 receptor; CCK2-R; cholecystokinin-2 receptor; gastrin/cholecystokinin type B receptor", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); toxic shock syndrome (Disease Ontology:DOID:14115); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cytochrome-c oxidase deficiency disease (Disease Ontology:DOID:3762); panic disorder (Disease Ontology:DOID:594)", "pathway": " (rno:25706); (R-RNO-375276); (R-RNO-416476); (R-RNO-881907)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "1528881;19959964;20843811;22981453;25601282;35674015", "class_list": "", "function": "CCK-B receptors mediate acetylcholine release through cell bodies of cholinergic interneurons in the corpus striatum., [RefSeq, PubMed]; CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production, [RefSeq, PubMed]; Cholecystokinin was one of the first gastrointestinal peptides discovered in the mammalian brain. Cholecystokinin receptors are members of the G protein-coupled receptor superfamily, stimulating phosphatidylinositol turnover and intracellular calcium mobilization. This gene encodes a cholecystokinin receptor of the B subtype. These receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. [provided by RefSeq, Jul 2008]., [RefSeq]; Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na(+)/H(+) Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway., [RefSeq, PubMed]; Pancreatic islet CCK1/2 receptors initiate somatosatin secretion through constitutive secretion controlled at the level of protein synthesis., [RefSeq, PubMed]; Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS (By similarity). Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by downregulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway (By similarity). In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Treatment with gastrin, a CCK2R agonist, stimulated the secretion of GLP-1, and that this effect was likely due to increased expression of proglucagon and PCSK1 (also known as prohormone convertase 3 (PC3 gene))., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0008188 neuropeptide receptor activity;GO:0015054 gastrin receptor activity;GO:0004951 cholecystokinin receptor activity;GO:0031741 type B gastrin/cholecystokinin receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0090274 positive regulation of somatostatin secretion;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P30553-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8M0-1", "uniprot_id": [ { "id": "G3V8M0_RAT", "url": "https://www.uniprot.org/uniprot/G3V8M0", "type": "external" } ], "mass": 65049.0, "length": 589, "protein_name": "Melanophilin", "gene_name": "Mlph", "organism": "Rat", "refseq_name": "melanophilin isoform 1", "refseq_ac": [ { "id": "NP_001419069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001419069", "type": "external" } ], "gene_names_uniprotkb": "Mlph", "gene_names_refseq": "Mlph", "protein_names_uniprotkb": "Melanophilin", "protein_names_refseq": "melanophilin isoform 1", "tax_id": 10116, "disease": "Griscelli syndrome type 3 (Disease Ontology:DOID:0060834)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66HE9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0017022 myosin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm;GO:0042470 melanosome;GO:0001725 stress fiber", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006605 protein targeting;GO:0043473 pigmentation;GO:0032400 melanosome localization;GO:0030318 melanocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V8M0-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8U1-1", "uniprot_id": [ { "id": "G3V8U1_RAT", "url": "https://www.uniprot.org/uniprot/G3V8U1", "type": "external" } ], "mass": 28024.0, "length": 252, "protein_name": "Transmembrane protein 101", "gene_name": "Tmem101", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmem101", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein 101", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:303564)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8U1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V8Z7-1", "uniprot_id": [ { "id": "G3V8Z7_RAT", "url": "https://www.uniprot.org/uniprot/G3V8Z7", "type": "external" } ], "mass": 11034.0, "length": 97, "protein_name": "Small integral membrane protein 8", "gene_name": "Smim8", "organism": "Rat", "refseq_name": "small integral membrane protein 8", "refseq_ac": [ { "id": "NP_001188303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188303", "type": "external" } ], "gene_names_uniprotkb": "Smim8", "gene_names_refseq": "RGD1305158; Smim8", "protein_names_uniprotkb": "Small integral membrane protein 8", "protein_names_refseq": "small integral membrane protein 8", "tax_id": 10116, "disease": "", "pathway": " (rno:297971)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V8Z7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V923-1", "uniprot_id": [ { "id": "G3V923_RAT", "url": "https://www.uniprot.org/uniprot/G3V923", "type": "external" } ], "mass": 45039.0, "length": 423, "protein_name": "SRY-box transcription factor 17", "gene_name": "Sox17", "organism": "Rat", "refseq_name": "transcription factor SOX-17", "refseq_ac": [ { "id": "NP_001101372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101372", "type": "external" } ], "gene_names_uniprotkb": "Sox17", "gene_names_refseq": "Sox17", "protein_names_uniprotkb": "SRY-box transcription factor 17", "protein_names_refseq": "SRY (sex determining region Y)-box 17; SRY box 17; SRY-box containing gene 17; transcription factor SOX-17", "tax_id": 10116, "disease": "intracranial aneurysm (Disease Ontology:DOID:10941); biliary atresia (Disease Ontology:DOID:13608); patent ductus arteriosus (Disease Ontology:DOID:13832); primary pulmonary hypertension (Disease Ontology:DOID:14557); cholangiocarcinoma (Disease Ontology:DOID:4947); pulmonary hypertension (Disease Ontology:DOID:6432); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (rno:312936); (R-RNO-3769402)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "36913491", "class_list": "", "function": "SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0043279 response to alkaloid;GO:0061010 gallbladder development;GO:0060214 endocardium formation;GO:0001714 endodermal cell fate specification;GO:0061031 endodermal digestive tract morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V923-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V939-1", "uniprot_id": [ { "id": "G3V939_RAT", "url": "https://www.uniprot.org/uniprot/G3V939", "type": "external" } ], "mass": 57007.0, "length": 516, "protein_name": "Keratin 82", "gene_name": "Krt82", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Krt82", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin 82", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-6805567); (R-RNO-6809371)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IG06", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V939-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9C4-1", "uniprot_id": [ { "id": "G3V9C4_RAT", "url": "https://www.uniprot.org/uniprot/G3V9C4", "type": "external" } ], "mass": 59691.0, "length": 520, "protein_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase", "gene_name": "St6galnac1", "organism": "Rat", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 precursor", "refseq_ac": [ { "id": "NP_001099329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099329", "type": "external" } ], "gene_names_uniprotkb": "St6galnac1", "gene_names_refseq": "Siat7A; St6galnac1", "protein_names_uniprotkb": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase; 2.4.3.3", "protein_names_refseq": "ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6 GalNAc alpha-2,6-sialyltransferase 1; ST6GALNAC1, alpha-2,6-sialyltransferase 1; alpha-2,6-sialyltransferase ST6GalNAc I; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 precursor; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) A", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)", "pathway": " (rno:287920); (R-RNO-4085001)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "30854566", "class_list": "", "function": "Sialyltransferase7A promotes angiotensin II-induced cardiomyocyte hypertrophy via HIF-1alpha-TAK1 signalling pathway., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.3", "type": "external" }, { "id": "2.4.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.7", "type": "external" } ], "go_molecular_function": "GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0009312 oligosaccharide biosynthetic process;GO:0048874 host-mediated modulation of intestinal microbiota composition;GO:0051851 host-mediated perturbation of symbiont process", "synthesized_glycan_count": 550, "hit_score": 0.2, "record_id": "G3V9C4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04807-1", "uniprot_id": [ { "id": "GLCM1_RAT", "url": "https://www.uniprot.org/uniprot/Q04807", "type": "external" } ], "mass": 15440.0, "length": 146, "protein_name": "Glycosylation-dependent cell adhesion molecule 1", "gene_name": "Glycam1", "organism": "Rat", "refseq_name": "glycosylation-dependent cell adhesion molecule 1 precursor", "refseq_ac": [ { "id": "NP_036926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036926", "type": "external" } ], "gene_names_uniprotkb": "Glycam1", "gene_names_refseq": "Glycam1", "protein_names_uniprotkb": "Glycosylation-dependent cell adhesion molecule 1; Endothelial ligand FOR L-selectin; GlyCAM-1; SGP50; Sulfated 50 kDa glycoprotein", "protein_names_refseq": "SGP50; endothelial ligand FOR L-selectin; glyCAM-1; glycosylation-dependent cell adhesion molecule 1 precursor; sulfated 50 kDa glycoprotein", "tax_id": 10116, "disease": "synucleinopathy (Disease Ontology:DOID:0050890); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:25258)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8100229", "class_list": "", "function": "Adhesion molecule that accomplishes cell binding by presenting carbohydrate(s) to the lectin domain of L-selectin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q04807-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9M2-1", "uniprot_id": [ { "id": "JIP2_RAT", "url": "https://www.uniprot.org/uniprot/G3V9M2", "type": "external" } ], "mass": 90476.0, "length": 835, "protein_name": "C-Jun-amino-terminal kinase-interacting protein 2", "gene_name": "Mapk8ip2", "organism": "Rat", "refseq_name": "C-Jun-amino-terminal kinase-interacting protein 2", "refseq_ac": [ { "id": "NP_001094190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094190", "type": "external" } ], "gene_names_uniprotkb": "Mapk8ip2; Ib2; Jip2", "gene_names_refseq": "IB-2; JIP-2; Mapk8ip2", "protein_names_uniprotkb": "C-Jun-amino-terminal kinase-interacting protein 2; IB-2; Islet-brain-2; JIP-2; JNK MAP kinase scaffold protein 2; JNK-interacting protein 2; Mitogen-activated protein kinase 8-interacting protein 2", "protein_names_refseq": "C-Jun-amino-terminal kinase-interacting protein 2; JNK MAP kinase scaffold protein 2; JNK-interacting protein 2; islet-brain-2", "tax_id": 10116, "disease": "", "pathway": " (rno:315220)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22128169", "class_list": "", "function": "The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3B8P9", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity;GO:0044877 protein-containing complex binding;GO:0019894 kinesin binding;GO:0005078 MAP-kinase scaffold activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0043025 neuronal cell body;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046958 nonassociative learning;GO:0007617 mating behavior;GO:0098815 modulation of excitatory postsynaptic potential;GO:0000165 MAPK cascade;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V9M2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9N0-1", "uniprot_id": [ { "id": "G3V9N0_RAT", "url": "https://www.uniprot.org/uniprot/G3V9N0", "type": "external" } ], "mass": 72412.0, "length": 660, "protein_name": "Polyadenylate-binding protein", "gene_name": "Pabpc4", "organism": "Rat", "refseq_name": "polyadenylate-binding protein 4 isoform 3", "refseq_ac": [ { "id": "NP_001423635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423635", "type": "external" } ], "gene_names_uniprotkb": "Pabpc4", "gene_names_refseq": "Pabpc4", "protein_names_uniprotkb": "Polyadenylate-binding protein; PABP", "protein_names_refseq": "poly(A) binding protein, cytoplasmic 4 (inducible form); polyadenylate-binding protein 4 isoform 3; polyadenylate-binding protein 4", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds the poly(A) tail of mRNA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2GUY3", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0043488 regulation of mRNA stability;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0061515 myeloid cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V9N0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51111-1", "uniprot_id": [ { "id": "HD_RAT", "url": "https://www.uniprot.org/uniprot/P51111", "type": "external" } ], "mass": 343762.0, "length": 3110, "protein_name": "Huntingtin", "gene_name": "Htt", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Htt; Hdh; Hd", "gene_names_refseq": "", "protein_names_uniprotkb": "Huntingtin; HD protein homolog; Huntington disease protein homolog", "protein_names_refseq": "", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:29424)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;8275091;8528205", "class_list": "", "function": "May play a role in microtubule-mediated transport or vesicle function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Promotes the formation of autophagic vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0031072 heat shock protein binding;GO:0044325 transmembrane transporter binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome", "go_biological_process": "GO:0048341 paraxial mesoderm formation;GO:1901526 positive regulation of mitophagy;GO:0006839 mitochondrial transport;GO:0007283 spermatogenesis;GO:0007611 learning or memory", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51111-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9Q9-1", "uniprot_id": [ { "id": "GTA1L_RAT", "url": "https://www.uniprot.org/uniprot/G3V9Q9", "type": "external" } ], "mass": 38343.0, "length": 321, "protein_name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1", "gene_name": "Ggta1l1", "organism": "Rat", "refseq_name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1", "refseq_ac": [ { "id": "NP_001032672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032672", "type": "external" } ], "gene_names_uniprotkb": "Ggta1l1", "gene_names_refseq": "Ggta1l1; Ggta1; Glt6d1", "protein_names_uniprotkb": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1; 2.4.1.87", "protein_names_refseq": "ABO-family member 5; ABO-family member protein 5; N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1; N-acetyllactosaminide alpha-1,3-galactosyltransferase; UDP-galactose:beta-D-galactosyl-1, 4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase; galactosyltransferase; glycosyltransferase 6 domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:652927)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "glycogene;glycosyltransferase", "function": "Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 3, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.87", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity;GO:0016758 hexosyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031982 vesicle;GO:0032580 Golgi cisterna membrane;GO:0016020 membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G3V9Q9-1", "record_type": "protein", "filter_code": "0000000.1000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EB81-1", "uniprot_id": [ { "id": "NB5R1_RAT", "url": "https://www.uniprot.org/uniprot/Q5EB81", "type": "external" } ], "mass": 34223.0, "length": 305, "protein_name": "NADH-cytochrome b5 reductase 1", "gene_name": "Cyb5r1", "organism": "Rat", "refseq_name": "NADH-cytochrome b5 reductase 1", "refseq_ac": [ { "id": "NP_001013144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013144", "type": "external" } ], "gene_names_uniprotkb": "Cyb5r1", "gene_names_refseq": "Cyb5r1; Nqo3a2", "protein_names_uniprotkb": "NADH-cytochrome b5 reductase 1; 1.6.2.2; b5R.1", "protein_names_refseq": "NAD(P)H:quinone oxidoreductase type 3, polypeptide A2; NADH-cytochrome b5 reductase 1; b5R.1", "tax_id": 10116, "disease": "methemoglobinemia (Disease Ontology:DOID:10783)", "pathway": " (rno:304805); (R-RNO-114608); (R-RNO-1237044)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22200675", "class_list": "", "function": "Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor., [UniProtKB, UniProtKB]; Stimulation and clustering of cytochrome b5 reductase in caveolin-rich lipid microdomains is an early event in oxidative stress-mediated apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016126 sterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EB81-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R410-1", "uniprot_id": [ { "id": "M0R410_RAT", "url": "https://www.uniprot.org/uniprot/M0R410", "type": "external" } ], "mass": 200403.0, "length": 1860, "protein_name": "RP1 like 1", "gene_name": "Rp1l1", "organism": "Rat", "refseq_name": "retinitis pigmentosa 1-like 1 protein", "refseq_ac": [ { "id": "NP_001408014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001408014", "type": "external" } ], "gene_names_uniprotkb": "Rp1l1; LOC683404", "gene_names_refseq": "Rp1l1", "protein_names_uniprotkb": "RP1 like 1", "protein_names_refseq": "retinitis pigmentosa 1-like 1 protein; retinitis pigmentosa 1-like 1", "tax_id": 10116, "disease": "occult macular dystrophy (Disease Ontology:DOID:0050578); retinitis pigmentosa 88 (Disease Ontology:DOID:0112145); eye disease (Disease Ontology:DOID:5614)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005930 axoneme;GO:0032391 photoreceptor connecting cilium;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0045494 photoreceptor cell maintenance;GO:0060041 retina development in camera-type eye;GO:0035845 photoreceptor cell outer segment organization;GO:0042461 photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R410-1", "record_type": "protein", "filter_code": "0000000.0000010.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17209-1", "uniprot_id": [ { "id": "MYL4_RAT", "url": "https://www.uniprot.org/uniprot/P17209", "type": "external" } ], "mass": 21282.0, "length": 193, "protein_name": "Myosin light chain 4", "gene_name": "Myl4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Myl4", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin light chain 4; Myosin light chain 1, atrial isoform", "protein_names_refseq": "", "tax_id": 10116, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (rno:688228); (R-RNO-390522)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2326197", "class_list": "", "function": "Regulatory light chain of myosin. Does not bind calcium., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0031672 A band;GO:0016460 myosin II complex;GO:0016459 myosin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0060048 cardiac muscle contraction;GO:0002026 regulation of the force of heart contraction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P17209-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R501-1", "uniprot_id": [ { "id": "M0R501_RAT", "url": "https://www.uniprot.org/uniprot/M0R501", "type": "external" } ], "mass": 83958.0, "length": 777, "protein_name": "Family with sequence similarity 83, member C", "gene_name": "Fam83c", "organism": "Rat", "refseq_name": "family with sequence similarity 83, member C", "refseq_ac": [ { "id": "NP_001418676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001418676", "type": "external" } ], "gene_names_uniprotkb": "Fam83c; LOC683506", "gene_names_refseq": "Fam83c; Sack1c", "protein_names_uniprotkb": "Family with sequence similarity 83, member C", "protein_names_refseq": "family with sequence similarity 83, member C", "tax_id": 10116, "disease": "", "pathway": " (rno:683506)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R501-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R521-1", "uniprot_id": [ { "id": "M0R521_RAT", "url": "https://www.uniprot.org/uniprot/M0R521", "type": "external" } ], "mass": 39874.0, "length": 355, "protein_name": "Arrestin domain containing 5", "gene_name": "Arrdc5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Arrdc5", "gene_names_refseq": "", "protein_names_uniprotkb": "Arrestin domain containing 5", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:680452)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, 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cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0R521-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0R5R5-1", "uniprot_id": [ { "id": "M0R5R5_RAT", "url": "https://www.uniprot.org/uniprot/M0R5R5", "type": "external" } ], "mass": 23876.0, "length": 215, "protein_name": "Cilia and flagella associated protein 90", "gene_name": "Cfap90", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cfap90", "gene_names_refseq": "", "protein_names_uniprotkb": "Cilia and flagella associated protein 90", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:361192)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", 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LOC684509", "gene_names_refseq": "", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3; Complex I-B9; NADH-ubiquinone oxidoreductase B9 subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RB63-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RC39-1", "uniprot_id": [ { "id": "M0RC39_RAT", "url": "https://www.uniprot.org/uniprot/M0RC39", "type": "external" } ], "mass": 35126.0, "length": 311, "protein_name": "Olfactory receptor", "gene_name": "Or4f60", "organism": "Rat", "refseq_name": "olfactory receptor Olr796", "refseq_ac": [ { "id": "NP_001000600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001000600", "type": "external" } ], "gene_names_uniprotkb": "Or4f60", "gene_names_refseq": "Olr796; Or4f60", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 796; olfactory receptor Olr796; olfactory receptor gene Olr796", "tax_id": 10116, "disease": "", "pathway": " (rno:404788)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RC39-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RD19-1", "uniprot_id": [ { "id": "M0RD19_RAT", "url": "https://www.uniprot.org/uniprot/M0RD19", "type": "external" } ], "mass": 35345.0, "length": 312, "protein_name": "Olfactory receptor", "gene_name": "Or8c19", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Or8c19", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "M0RD19-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55148-1", "uniprot_id": [ { "id": "GAS7_RAT", "url": "https://www.uniprot.org/uniprot/O55148", "type": "external" } ], "mass": 48275.0, "length": 422, "protein_name": "Growth arrest-specific protein 7", "gene_name": "Gas7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gas7", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth arrest-specific protein 7; GAS-7", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:85246)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in promoting maturation and morphological differentiation of cerebellar neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030136 clathrin-coated vesicle", "go_biological_process": "GO:0048812 neuron projection morphogenesis;GO:0051017 actin filament bundle assembly;GO:0030182 neuron differentiation;GO:0008360 regulation of cell shape;GO:0030041 actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O55148-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08725-1", "uniprot_id": [ { "id": "GHSR_RAT", "url": "https://www.uniprot.org/uniprot/O08725", "type": "external" } ], "mass": 40963.0, "length": 364, "protein_name": "Growth hormone secretagogue receptor type 1", "gene_name": "Ghsr", "organism": "Rat", "refseq_name": "growth hormone secretagogue receptor type 1", "refseq_ac": [ { "id": "NP_114464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114464", "type": "external" } ], "gene_names_uniprotkb": "Ghsr", "gene_names_refseq": "Ghsr", "protein_names_uniprotkb": "Growth hormone secretagogue receptor type 1; GH-releasing peptide receptor; GHRP; GHS-R; Ghrelin receptor", "protein_names_refseq": "GH-releasing peptide receptor; GHRP; GHS-R; ghrelin receptor; growth hormone secretagogue receptor type 1", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); isolated growth hormone deficiency (Disease Ontology:DOID:0060870); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); multiple endocrine neoplasia (Disease Ontology:DOID:3125); middle cerebral artery infarction (Disease Ontology:DOID:3525); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:84022); (R-RNO-416476)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10604470;32814069;33264473;35255434;35365872;38187112;9092793;9437732", "class_list": "", "function": "Brain and kidney GHS-R1a underexpression is associated with changes in renal function and hemodynamics during neurogenic hypertension., [RefSeq, PubMed]; Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers., [RefSeq, PubMed]; Energetic demands of lactation produce an increase in the expression of growth hormone secretagogue receptor in the hypothalamus and ventral tegmental area of the rat despite a reduction in circulating ghrelin., [RefSeq, PubMed]; G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach (By similarity). Upon activation, stimulates appetite and promotes growth hormone secretion (PubMed:10604470). Also binds other growth hormone releasing peptides (GHRP) as well as non-peptide, low molecular weight secretagogues (PubMed:10604470)., [UniProtKB, PubMed, UniProtKB]; Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated Intestinal Barrier Dysfunction in a Sepsis Rat Model by Inactivating E2F1/NF-kappaB Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Virus-mediated GHS-R1a expression in the basolateral amygdala blocks extinction of conditioned taste aversion memory in rats., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:0042562 hormone binding;GO:0017046 peptide hormone binding;GO:0001616 growth hormone secretagogue receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft;GO:0098794 postsynapse", "go_biological_process": "GO:0060123 regulation of growth hormone secretion;GO:1903672 positive regulation of sprouting angiogenesis;GO:0032100 positive regulation of appetite;GO:0120058 positive regulation of small intestinal transit;GO:1904000 positive regulation of eating behavior", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O08725-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35115-1", "uniprot_id": [ { "id": "FHL2_RAT", "url": "https://www.uniprot.org/uniprot/O35115", "type": "external" } ], "mass": 32087.0, "length": 279, "protein_name": "Four and a half LIM domains protein 2", "gene_name": "Fhl2", "organism": "Rat", "refseq_name": "four and a half LIM domains protein 2", "refseq_ac": [ { "id": "NP_113865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113865", "type": "external" } ], "gene_names_uniprotkb": "Fhl2; Dral; Slim3", "gene_names_refseq": "Fhl2; SLIM 3", "protein_names_uniprotkb": "Four and a half LIM domains protein 2; FHL-2; LIM domain protein DRAL; SLIM-3; Skeletal muscle LIM-protein 3", "protein_names_refseq": "LIM domain protein DRAL; four and a half LIM domains protein 2; skeletal muscle LIM-protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:63839)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "11001931;11813260;22851699;25103794;29771425;34342639;35176204", "class_list": "", "function": "CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes., [RefSeq, PubMed]; FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply., [RefSeq, PubMed]; FHL2 inhibits hypertrophic growth induced by calcineurin in neonatal rat ventricular myocytes., [RefSeq, PubMed]; FHL2 is involved in renal interstitial fibrosis by altering the phenotype of renal tubular epithelial cells via regulating the beta-catenin pathway., [RefSeq, PubMed]; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:22851699)., [UniProtKB, UniProtKB, PubMed]; This study illustrated the FHL2-driven molecular network controlling SEPT2-mediated apoptosis in mesangial cell and their potential roles in mesangial proliferative nephritis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity;GO:0008134 transcription factor binding;GO:0043425 bHLH transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0030018 Z disc;GO:0031430 M band", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35115-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35532-1", "uniprot_id": [ { "id": "MSMO1_RAT", "url": "https://www.uniprot.org/uniprot/O35532", "type": "external" } ], "mass": 34964.0, "length": 293, "protein_name": "Methylsterol monooxygenase 1", "gene_name": "Msmo1", "organism": "Rat", "refseq_name": "methylsterol monooxygenase 1", "refseq_ac": [ { "id": "NP_543162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543162", "type": "external" } ], "gene_names_uniprotkb": "Msmo1; Sc4mol", "gene_names_refseq": "Msmo1; Sc4mol", "protein_names_uniprotkb": "Methylsterol monooxygenase 1; 1.14.18.9; C-4 methylsterol oxidase; Neuropep 1; RANP-1; Sterol-C4-methyl oxidase", "protein_names_refseq": "C-4 methylsterol oxidase; RANP-1; methylsterol monooxygenase 1; neuropep 1; neurorep 1; sterol-C4-methyl oxidase", "tax_id": 10116, "disease": "chondrodysplasia punctata (Disease Ontology:DOID:2581)", "pathway": " (rno:140910); (R-RNO-6807047)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "28970091;4394229;7228857;9284352", "class_list": "", "function": "Among the identified sterol associated genes, we detected that methylsterol monooxygenase 1 (Msmo1) was more sensitively induced compared to Cyp51, a classical biomarker of this pathway. Therefore, we suggest that Msmo1 could be a better biomarker for screening the fungicidal value of azoles., [RefSeq, PubMed]; Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.18.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.9", "type": "external" } ], "go_molecular_function": "GO:0000254 C-4 methylsterol oxidase activity;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016126 sterol biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0036197 zymosterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35532-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35821-1", "uniprot_id": [ { "id": "MBB1A_RAT", "url": "https://www.uniprot.org/uniprot/O35821", "type": "external" } ], "mass": 152286.0, "length": 1344, "protein_name": "Myb-binding protein 1A", "gene_name": "Mybbp1a", "organism": "Rat", "refseq_name": "myb-binding protein 1A", "refseq_ac": [ { "id": "NP_113856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113856", "type": "external" } ], "gene_names_uniprotkb": "Mybbp1a", "gene_names_refseq": "DBP; Mybbp1a", "protein_names_uniprotkb": "Myb-binding protein 1A; PAR-interacting protein; PIP", "protein_names_refseq": "MYB binding protein (P160) 1a; PAR-interacting protein; PIP; myb-binding protein 1A", "tax_id": 10116, "disease": "", "pathway": " (rno:60571); (R-RNO-5250924)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0043565 sequence-specific DNA binding;GO:0070888 E-box binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0042564 NLS-dependent protein nuclear import complex;GO:0110016 B-WICH complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0042254 ribosome biogenesis;GO:0042149 cellular response to glucose starvation;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35821-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55162-1", "uniprot_id": [ { "id": "LYPD3_RAT", "url": "https://www.uniprot.org/uniprot/O55162", "type": "external" } ], "mass": 36961.0, "length": 352, "protein_name": "Ly6/PLAUR domain-containing protein 3", "gene_name": "Lypd3", "organism": "Rat", "refseq_name": "ly6/PLAUR domain-containing protein 3 precursor", "refseq_ac": [ { "id": "NP_068527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068527", "type": "external" } ], "gene_names_uniprotkb": "Lypd3; C4.4a", "gene_names_refseq": "C4.4a; Lypd3", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 3; GPI-anchored metastasis-associated protein C4.4A", "protein_names_refseq": "GPI-anchored metastasis-associated protein C4.4A; GPI-anchored metastasis-associated protein homolog; ly6/PLAUR domain-containing protein 3 precursor; ly6/PLAUR domain-containing protein 3; metastasis-associated GPI-anchored protein; metastasis-associated molecule", "tax_id": 10116, "disease": "", "pathway": " (rno:60378); (R-RNO-163125)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15729693;21339181;22431918;9788443", "class_list": "", "function": "A possible functional role of C4.4A in early differentiation of stratified squamous epithelia, [RefSeq, PubMed]; Supports cell migration. May be involved in tumor progression., [UniProtKB, PubMed, PubMed]; The first explanation for the C4.4A contribution to wound healing and metastasis., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043236 laminin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0034392 negative regulation of smooth muscle cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O55162-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70351-1", "uniprot_id": [ { "id": "HCD2_RAT", "url": "https://www.uniprot.org/uniprot/O70351", "type": "external" } ], "mass": 27246.0, "length": 261, "protein_name": "3-hydroxyacyl-CoA dehydrogenase type-2", "gene_name": "Hsd17b10", "organism": "Rat", "refseq_name": "3-hydroxyacyl-CoA dehydrogenase type-2", "refseq_ac": [ { "id": "NP_113870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113870", "type": "external" } ], "gene_names_uniprotkb": "Hsd17b10; Erab; Hadh2", "gene_names_refseq": "ABAD; ERAB; HSD10; Hadh2; Hsd17b10; MHBD", "protein_names_uniprotkb": "3-hydroxyacyl-CoA dehydrogenase type-2; 1.1.1.159; 1.1.1.178; 1.1.1.239; 1.1.1.35; 1.1.1.53; 1.1.1.62; 17-beta-estradiol 17-dehydrogenase; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3alpha(or 20beta)-hydroxysteroid dehydrogenase; 7-alpha-hydroxysteroid dehydrogenase; Endoplasmic reticulum-associated amyloid beta-peptide-binding protein; MHBD; Mitochondrial RNase P protein 2; Mitochondrial ribonuclease P protein 2; Short chain dehydrogenase/reductase family 5C member 1; Short-chain type dehydrogenase/reductase XH98G2; Type II HADH", "protein_names_refseq": "17-beta-HSD 10; 17-beta-estradiol 17-dehydrogenase; 17-beta-hydroxysteroid dehydrogenase 10; 17I(2)-hydroxysteroid dehydrogenase type 10; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3-hydroxyacyl-CoA dehydrogenase type-2; 3alpha(or 20beta)-hydroxysteroid dehydrogenase; 7-alpha-hydroxysteroid dehydrogenase; amyloid beta-peptide binding protein; amyloid-beta peptide binding alcohol dehydrogenase; endoplasmic reticulum-associated amyloid beta-peptide-binding protein; hydroxyacyl-Coenzyme A dehydrogenase, type II; mitochondrial RNase P protein 2; mitochondrial ribonuclease P protein 2; short chain L-3-hydroxyacyl-CoA dehydrogenase; short chain dehydrogenase/reductase family 5C member 1; short-chain type dehydrogenase/reductase XH98G2; type II HADH", "tax_id": 10116, "disease": "pheochromocytoma (Disease Ontology:DOID:0050771); syndromic X-linked intellectual disability type 10 (Disease Ontology:DOID:0060810); Alzheimer's disease (Disease Ontology:DOID:10652); osteosarcoma (Disease Ontology:DOID:3347)", "pathway": " (rno:63864); (R-RNO-70895); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11023795;27213235;28100784;34502162", "class_list": "", "function": "In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends. Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly., [UniProtKB, UniProtKB]; Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism. Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA. Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway. Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids. Oxidizes allopregnanolone/brexanolone at the 3alpha-hydroxyl group, which is known to be critical for the activation of gamma-aminobutyric acid receptors (GABAARs) chloride channel. Has phospholipase C-like activity toward cardiolipin and its oxidized species. Likely oxidizes the 2'-hydroxyl in the head group of cardiolipin to form a ketone intermediate that undergoes nucleophilic attack by water and fragments into diacylglycerol, dihydroxyacetone and orthophosphate. Has higher affinity for cardiolipin with oxidized fatty acids and may degrade these species during the oxidative stress response to protect cells from apoptosis. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structural and functional integrity of mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYD4", "ec_number_list": [ { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "1.1.1.211", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.211", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0001540 amyloid-beta binding;GO:0051287 NAD binding;GO:0000049 tRNA binding;GO:0005496 steroid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0042645 mitochondrial nucleoid;GO:1902494 catalytic complex;GO:0030678 mitochondrial ribonuclease P complex", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0062173 brexanolone metabolic process;GO:0006631 fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006699 bile acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70351-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88204-1", "uniprot_id": [ { "id": "LRP3_RAT", "url": "https://www.uniprot.org/uniprot/O88204", "type": "external" } ], "mass": 83017.0, "length": 770, "protein_name": "Low-density lipoprotein receptor-related protein 3", "gene_name": "Lrp3", "organism": "Rat", "refseq_name": "low-density lipoprotein receptor-related protein 3 precursor", "refseq_ac": [ { "id": "NP_445993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445993", "type": "external" } ], "gene_names_uniprotkb": "Lrp3; Lrp105", "gene_names_refseq": "Lrp3", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 3; 105 kDa low-density lipoprotein receptor-related protein; LRP-3; rLRp105", "protein_names_refseq": "105 kDa low-density lipoprotein receptor-related protein; LRP-3; low-density lipoprotein receptor-related protein 3 precursor; low-density lipoprotein receptor-related protein 3; rLRp105", "tax_id": 10116, "disease": "", "pathway": " (rno:89787)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11390366;9693042", "class_list": "", "function": "Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0006897 endocytosis;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045669 positive regulation of osteoblast differentiation;GO:0045599 negative regulation of fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O88204-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88206-1", "uniprot_id": [ { "id": "O88206_RAT", "url": "https://www.uniprot.org/uniprot/O88206", "type": "external" } ], "mass": 13928.0, "length": 124, "protein_name": "Trophoblast specific protein alpha", "gene_name": "Tpbpa", "organism": "Rat", "refseq_name": "trophoblast specific protein alpha precursor", "refseq_ac": [ { "id": "NP_742070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742070", "type": "external" } ], "gene_names_uniprotkb": "Tpbpa", "gene_names_refseq": "Tpbpa; Tpbp", "protein_names_uniprotkb": "Trophoblast specific protein alpha", "protein_names_refseq": "spongiotrophoblast specific protein; trophoblast specific protein alpha precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:64509)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O88206-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88791-1", "uniprot_id": [ { "id": "O88791_RAT", "url": "https://www.uniprot.org/uniprot/O88791", "type": "external" } ], "mass": 11676.0, "length": 107, "protein_name": "High mobility group AT-hook 2", "gene_name": "Hmga2", "organism": "Rat", "refseq_name": "high mobility group protein HMGI-C", "refseq_ac": [ { "id": "NP_114459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114459", "type": "external" } ], "gene_names_uniprotkb": "Hmga2", "gene_names_refseq": "Hmga2; Hmgic", "protein_names_uniprotkb": "High mobility group AT-hook 2", "protein_names_refseq": "high mobility group protein HMGI-C; non-histone chromosomal architectural protein HMGI-C", "tax_id": 10116, "disease": "leiomyoma (Disease Ontology:DOID:127); Silver-Russell syndrome (Disease Ontology:DOID:14681); ovarian cancer (Disease Ontology:DOID:2394); lipoma (Disease Ontology:DOID:3315); hamartoma (Disease Ontology:DOID:3462)", "pathway": " (rno:84017); (R-RNO-2559584)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "22673903;30934671;32068957;32370714;33749722;35966335", "class_list": "", "function": "HMGA2 Promotes Brain Injury in Rats with Cerebral Infarction by Activating TLR4/NF-kappaB Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells., [RefSeq, PubMed]; MicroR-26b Targets High Mobility Group, AT-hook 2 to Ameliorate Myocardial Infarction-induced Fibrosis by Suppression of Cardiac Fibroblasts Activation., [RefSeq, PubMed]; The anti-apoptotic effects of Let-7d-3p mimic during hypoxia challenge are due to direct targeting of HMGA2. Publication Status: Online-Only, [RefSeq, PubMed]; The protective effects of HMGA2 in the senescence process of bone marrow-derived mesenchymal stromal cells., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1M940", "ec_number_list": [], "go_molecular_function": "GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0008301 DNA binding, bending;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032993 protein-DNA complex;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0060123 regulation of growth hormone secretion;GO:2000648 positive regulation of stem cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88791-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89117-1", "uniprot_id": [ { "id": "DEFB1_RAT", "url": "https://www.uniprot.org/uniprot/O89117", "type": "external" } ], "mass": 7837.0, "length": 69, "protein_name": "Beta-defensin 1", "gene_name": "Defb1", "organism": "Rat", "refseq_name": "beta-defensin 1 precursor", "refseq_ac": [ { "id": "NP_113998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113998", "type": "external" } ], "gene_names_uniprotkb": "Defb1", "gene_names_refseq": "CDK4; Defb1", "protein_names_uniprotkb": "Beta-defensin 1; BD-1; Defensin, beta 1; rBD-1", "protein_names_refseq": "BD-1; beta-defensin 1 precursor; beta-defensin 1; rBD-1", "tax_id": 10116, "disease": "pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); pulmonary sarcoidosis (Disease Ontology:DOID:13406); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); pneumonia (Disease Ontology:DOID:552); lung disease (Disease Ontology:DOID:850); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:83687); (R-RNO-1461957); (R-RNO-1461973)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10456937;31637753", "class_list": "", "function": "Expression perturbed in diabetes, [RefSeq, PubMed]; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003690 double-stranded DNA binding;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0097225 sperm midpiece;GO:1990742 microvesicle", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O89117-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00159-1", "uniprot_id": [ { "id": "CYB_RAT", "url": "https://www.uniprot.org/uniprot/P00159", "type": "external" } ], "mass": 43012.0, "length": 380, "protein_name": "Cytochrome b", "gene_name": "Mt-cyb", "organism": "Rat", "refseq_name": "cytochrome b", "refseq_ac": [ { "id": "YP_665641", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_665641", "type": "external" } ], "gene_names_uniprotkb": "Mt-cyb; Cob; Cytb; Mtcyb", "gene_names_refseq": "CYTB", "protein_names_uniprotkb": "Cytochrome b; Complex III subunit 3; Complex III subunit III; Cytochrome b-c1 complex subunit 3; Ubiquinol-cytochrome-c reductase complex cytochrome b subunit", "protein_names_refseq": "cytochrome b", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); ovarian carcinoma (Disease Ontology:DOID:4001); thyrotoxicosis (Disease Ontology:DOID:7997); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:26192); (R-RNO-5419276); (R-RNO-611105); (R-RNO-9865881)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "24186299;2504926;6299885;6326133", "class_list": "", "function": "Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0044877 protein-containing complex binding;GO:0016491 oxidoreductase activity;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0032991 protein-containing complex;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0007584 response to nutrient;GO:0045471 response to ethanol;GO:0051592 response to calcium ion;GO:0001666 response to hypoxia;GO:0046686 response to cadmium ion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P00159-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00388-1", "uniprot_id": [ { "id": "NCPR_RAT", "url": "https://www.uniprot.org/uniprot/P00388", "type": "external" } ], "mass": 76963.0, "length": 678, "protein_name": "NADPH--cytochrome P450 reductase", "gene_name": "Por", "organism": "Rat", "refseq_name": "NADPH--cytochrome P450 reductase", "refseq_ac": [ { "id": "NP_113764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113764", "type": "external" } ], "gene_names_uniprotkb": "Por; POR", "gene_names_refseq": "CYPOR; Por", "protein_names_uniprotkb": "NADPH--cytochrome P450 reductase; 1.6.2.4; CPR; P450R", "protein_names_refseq": "CPR; NADPH--cytochrome P450 reductase; P450 (cytochrome) oxidoreductase; P450R; cytochrome P450 reductase", "tax_id": 10116, "disease": "Antley-Bixler syndrome with disordered steroidogenesis (Disease Ontology:DOID:0050462); congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); cytochrome P450 oxidoreductase deficiency (Disease Ontology:DOID:0080925)", "pathway": " (rno:29441)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11371558;19171935;2125483;21345800;27189945;28684414;29308883;3082610;34196520;3919392;9237990", "class_list": "", "function": "Data suggest CYP17A1, with electron donor NADPH-P450 reductase, is inherently distributive enzyme but that some processivity is present; some 17alpha-hydroxy pregnenolone formed does not dissociate from CYP17A1 before conversion to dehydroepiandrosterone; CYB5A does not enhance reaction by decreasing k(off) of ligands of CYP17A1. (CYP17A1 = cytochrome P450, family 17, subfamily A, polypeptide 1; CYB5A = cytochrome b5), [RefSeq, PubMed]; Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase., [RefSeq, PubMed]; The DeltaGly-143 protein had moderately decreased activity with cytochrome P450 and cytochrome c. It formed a flexible loop, which transiently interacts with the flavin N5, resulting in the generation of both an unstable neutral blue semiquinone and hydroquinone., [RefSeq, PubMed]; The structure of four-electron-reduced, NADP(+)-bound wild type CYPOR shows the plane of the nicotinamide ring positioned perpendicular to the FAD isoalloxazine with its carboxamide group forming H-bonds with N1 of the flavin ring and the Thr535 hydroxyl group., [RefSeq, PubMed]; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0009055 electron transfer activity;GO:0016787 hydrolase activity;GO:0019899 enzyme binding;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007584 response to nutrient;GO:0043066 negative regulation of apoptotic process;GO:0019395 fatty acid oxidation;GO:0032332 positive regulation of chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P00388-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00502-1", "uniprot_id": [ { "id": "GSTA1_RAT", "url": "https://www.uniprot.org/uniprot/P00502", "type": "external" } ], "mass": 25607.0, "length": 222, "protein_name": "Glutathione S-transferase alpha-1", "gene_name": "Gsta1", "organism": "Rat", "refseq_name": "glutathione S-transferase alpha-1", "refseq_ac": [ { "id": "NP_058709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058709", "type": "external" } ], "gene_names_uniprotkb": "Gsta1", "gene_names_refseq": "GST B; Gsta1; Gsta2", "protein_names_uniprotkb": "Glutathione S-transferase alpha-1; 1.11.1.-; 13-hydroperoxyoctadecadienoate peroxidase; 2.5.1.18; 5.3.3.-; Androst-5-ene-3,17-dione isomerase; GST 1-1; GST 1a-1a; GST A1-1; GST B; GST Ya1; Glutathione S-transferase Ya-1; Ligandin", "protein_names_refseq": "13-hydroperoxyoctadecadienoate peroxidase; GST 1-1; GST 1a-1a; GST A1-1; GST Ya1; androst-5-ene-3,17-dione isomerase; glutathione S-transferase A2; glutathione S-transferase Ya subunit; glutathione S-transferase Ya-1; glutathione S-transferase alpha-1; glutathione-S-transferase, alpha type2; ligandin", "tax_id": 10116, "disease": "ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24422); (R-RNO-156590); (R-RNO-9748787)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "11119643;17786629;21905055;6201485;6273441", "class_list": "", "function": "C/EBP alpha and beta are involved in glucocorticoid-dependent repression of GSTA2 gene expression, [RefSeq, PubMed]; Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (By similarity)., [UniProtKB, PubMed, UniProtKB]; The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary alpha-GST and KIM-1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AZ72", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.145", "type": "external" }, { "id": "5.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.1", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0043295 glutathione binding;GO:0042803 protein homodimerization activity;GO:0004769 steroid Delta-isomerase activity;GO:0035731 dinitrosyl-iron complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0009617 response to bacterium;GO:0006805 xenobiotic metabolic process;GO:0042178 xenobiotic catabolic process;GO:0006693 prostaglandin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P00502-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true } ]