[ { "uniprot_canonical_ac": "Q6AYS4-1", "uniprot_id": [ { "id": "FUCO2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYS4", "type": "external" } ], "mass": 53258.0, "length": 459, "protein_name": "Plasma alpha-L-fucosidase", "gene_name": "Fuca2", "organism": "Rat", "refseq_name": "plasma alpha-L-fucosidase precursor", "refseq_ac": [ { "id": "NP_001004218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004218", "type": "external" } ], "gene_names_uniprotkb": "Fuca2", "gene_names_refseq": "Fuca2", "protein_names_uniprotkb": "Plasma alpha-L-fucosidase; 3.2.1.51; Alpha-L-fucosidase 2; Alpha-L-fucoside fucohydrolase 2", "protein_names_refseq": "alpha-L-fucoside fucohydrolase 2; fucosidase, alpha-L- 2, plasma; plasma alpha-L-fucosidase precursor; plasma alpha-L-fucosidase", "tax_id": 10116, "disease": "", "pathway": " (rno:292485); (R-RNO-381426); (R-RNO-6798695); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.2", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.4.21.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.20", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0004560 alpha-L-fucosidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:2000535 regulation of entry of bacterium into host cell;GO:0009617 response to bacterium;GO:0016139 glycoside catabolic process;GO:0006004 fucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYS4-1", "record_type": "protein", "filter_code": "0000000.1000001.100000.000000000000001000.0000000010001.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYT4-1", "uniprot_id": [ { "id": "PBIR1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYT4", "type": "external" } ], "mass": 30472.0, "length": 286, "protein_name": "P2R1A-PPP2R2A-interacting phosphatase regulator 1", "gene_name": "Pabir1", "organism": "Rat", "refseq_name": "P2R1A-PPP2R2A-interacting phosphatase regulator 1", "refseq_ac": [ { "id": "NP_001014051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014051", "type": "external" } ], "gene_names_uniprotkb": "Pabir1; Fam122a", "gene_names_refseq": "Fam122a; Pabir1; RGD1310316", "protein_names_uniprotkb": "P2R1A-PPP2R2A-interacting phosphatase regulator 1; PABIR family member 1", "protein_names_refseq": "P2R1A-PPP2R2A-interacting phosphatase regulator 1; PABIR family member 1; family with sequence similarity 122A; protein FAM122A", "tax_id": 10116, "disease": "", "pathway": " (rno:309420)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (By similarity). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (By similarity). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (By similarity). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0051721 protein phosphatase 2A binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0044818 mitotic G2/M transition checkpoint", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYT7-1", "uniprot_id": [ { "id": "ABD12_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYT7", "type": "external" } ], "mass": 45296.0, "length": 398, "protein_name": "Lysophosphatidylserine lipase ABHD12", "gene_name": "Abhd12", "organism": "Rat", "refseq_name": "lysophosphatidylserine lipase ABHD12", "refseq_ac": [ { "id": "NP_001019485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019485", "type": "external" } ], "gene_names_uniprotkb": "Abhd12", "gene_names_refseq": "Abhd12", "protein_names_uniprotkb": "Lysophosphatidylserine lipase ABHD12; 2-arachidonoylglycerol hydrolase ABHD12; 3.1.-.-; 3.1.1.-; 3.1.1.23; Abhydrolase domain-containing protein 12; Monoacylglycerol lipase ABHD12; Oxidized phosphatidylserine lipase ABHD12", "protein_names_refseq": "2-arachidonoylglycerol hydrolase ABHD12; abhydrolase domain-containing protein 12; lysophosphatidylserine lipase ABHD12; monoacylglycerol lipase ABHD12; oxidized phosphatidylserine lipase ABHD12", "tax_id": 10116, "disease": "PHARC syndrome (Disease Ontology:DOID:0080181)", "pathway": " (rno:499913); (R-RNO-426048)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.3.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0120560 phosphatidylserine lysophospholipase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032281 AMPA glutamate receptor complex;GO:0032839 dendrite cytoplasm", "go_biological_process": "GO:0009395 phospholipid catabolic process;GO:0046464 acylglycerol catabolic process;GO:0052651 monoacylglycerol catabolic process;GO:0006660 phosphatidylserine catabolic process;GO:0007628 adult walking behavior", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6AYT7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYT9-1", "uniprot_id": [ { "id": "ACSM5_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYT9", "type": "external" } ], "mass": 64623.0, "length": 578, "protein_name": "Acyl-coenzyme A synthetase ACSM5, mitochondrial", "gene_name": "Acsm5", "organism": "Rat", "refseq_name": "acyl-coenzyme A synthetase ACSM5, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001014184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014184", "type": "external" } ], "gene_names_uniprotkb": "Acsm5; Macs3", "gene_names_refseq": "Aa2-174; Acsm5; Cc1-38; RGD1309578", "protein_names_uniprotkb": "Acyl-coenzyme A synthetase ACSM5, mitochondrial; 6.2.1.2", "protein_names_refseq": "acyl-coenzyme A synthetase ACSM5, mitochondrial precursor; acyl-coenzyme A synthetase ACSM5, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:361637); (R-RNO-177128); (R-RNO-9749641)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acyl-CoA synthetase that catalyzes the ATP-dependent activation of fatty acids to their corresponding acyl-CoA thioesters, the first committed step in fatty acid metabolism (By similarity). Negatively regulates lipid accumulation via inhibition of FABP4-PPARgamma signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0004321 fatty-acyl-CoA synthase activity;GO:0015645 fatty acid ligase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYT9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYY8-1", "uniprot_id": [ { "id": "ACATN_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYY8", "type": "external" } ], "mass": 61101.0, "length": 550, "protein_name": "Acetyl-coenzyme A transporter 1", "gene_name": "Slc33a1", "organism": "Rat", "refseq_name": "acetyl-coenzyme A transporter 1", "refseq_ac": [ { "id": "NP_071588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071588", "type": "external" } ], "gene_names_uniprotkb": "Slc33a1; Acatn", "gene_names_refseq": "Acatn; Slc33a1", "protein_names_uniprotkb": "Acetyl-coenzyme A transporter 1; AT-1; Acetyl-CoA transporter 1; Solute carrier family 33 member 1", "protein_names_refseq": "AT-1; acetyl-CoA transporter 1; acetyl-coenzyme A transporter 1-like; acetyl-coenzyme A transporter 1; solute carrier family 33 (acetyl-CoA transporter), member 1", "tax_id": 10116, "disease": "hereditary spastic paraplegia 42 (Disease Ontology:DOID:0110794)", "pathway": " (rno:64018); (R-RNO-425397)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10965123", "class_list": "", "function": "Acetyl-CoA transporter that mediates active acetyl-CoA import through the endoplasmic reticulum (ER) membrane into the ER lumen where specific ER-based acetyl-CoA:lysine acetyltransferases are responsible for the acetylation of ER-based protein substrates, such as BACE1. Necessary for O-acetylation of gangliosides., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9JM68", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008521 acetyl-CoA transmembrane transporter activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035348 acetyl-CoA transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYY8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AZ83-1", "uniprot_id": [ { "id": "G6PC3_RAT", "url": "https://www.uniprot.org/uniprot/Q6AZ83", "type": "external" } ], "mass": 38834.0, "length": 346, "protein_name": "Glucose-6-phosphatase 3", "gene_name": "G6pc3", "organism": "Rat", "refseq_name": "glucose-6-phosphatase 3", "refseq_ac": [ { "id": "NP_788266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788266", "type": "external" } ], "gene_names_uniprotkb": "G6pc3", "gene_names_refseq": "G6pc3", "protein_names_uniprotkb": "Glucose-6-phosphatase 3; 3.1.3.9; G-6-Pase 3; G6Pase 3", "protein_names_refseq": "G-6-Pase 3; G6Pase 3; glucose 6 phosphatase, catalytic, 3; glucose-6-phosphatase 3; glucose-6-phosphatase catalytic subunit-related", "tax_id": 10116, "disease": "severe congenital neutropenia 4 (Disease Ontology:DOID:0112136)", "pathway": " (rno:303565); (R-RNO-70263)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17158265", "class_list": "", "function": "Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q811R7", "ec_number_list": [ { "id": "3.1.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.9", "type": "external" }, { "id": "3.1.3.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.94", "type": "external" }, { "id": "3.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.25", "type": "external" } ], "go_molecular_function": "GO:0004346 glucose-6-phosphatase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0015760 glucose-6-phosphate transport;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AZ83-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DGF6-1", "uniprot_id": [ { "id": "F220A_RAT", "url": "https://www.uniprot.org/uniprot/Q6DGF6", "type": "external" } ], "mass": 27739.0, "length": 259, "protein_name": "Protein FAM220A", "gene_name": "Fam220a", "organism": "Rat", "refseq_name": "protein FAM220A", "refseq_ac": [ { "id": "NP_001017485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017485", "type": "external" } ], "gene_names_uniprotkb": "Fam220a; Sipar", "gene_names_refseq": "Fam220a; Sipar", "protein_names_uniprotkb": "Protein FAM220A; STAT3-interacting protein as a repressor", "protein_names_refseq": "STAT3-interacting protein as a repressor; protein FAM220A", "tax_id": 10116, "disease": "", "pathway": " (rno:498145)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Promotes dephosphorylation of transcriptional activator STAT3 by interacting with both STAT3 and protein phosphatase PTPN2. This promotes interaction of PTPN2 with STAT3 and mediates STAT3 dephosphorylation by PTPN2, leading to negative regulation of STAT3 transcriptional activator activity. May be required for spermiogenesis or sperm function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097677 STAT family protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6DGF6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6EV76-1", "uniprot_id": [ { "id": "FUT8_RAT", "url": "https://www.uniprot.org/uniprot/Q6EV76", "type": "external" } ], "mass": 66485.0, "length": 575, "protein_name": "Alpha-(1,6)-fucosyltransferase", "gene_name": "Fut8", "organism": "Rat", "refseq_name": "alpha-(1,6)-fucosyltransferase", "refseq_ac": [ { "id": "NP_001002289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002289", "type": "external" } ], "gene_names_uniprotkb": "Fut8", "gene_names_refseq": "Fut8", "protein_names_uniprotkb": "Alpha-(1,6)-fucosyltransferase; 2.4.1.68; Alpha1-6FucT; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase", "protein_names_refseq": "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; GDP-fucose--glycoprotein fucosyltransferase; alpha-(1,6)-fucosyltransferase; alpha1-6FucT; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); glycoprotein 6-alpha-L-fucosyltransferase", "tax_id": 10116, "disease": "pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:432392); (R-RNO-975578)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21208406", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Fucosylates the reducing GlcNAc residue in complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs. Fully converts Fc glycoforms containing one or two terminal GlcNAc moieties (G0-GlcNAc and G0)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The cDNAs encoding the rat alpha1,6-fucosyltransferase (FucT VIII) were cloned from YB2/0 cells by polymerase chain reaction-based and 5' RNA-Ligase-Mediated RACE methods. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.68", "type": "external" } ], "go_molecular_function": "GO:0046921 alpha-(1->6)-fucosyltransferase activity;GO:0017124 SH3 domain binding;GO:0016757 glycosyltransferase activity;GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0007585 respiratory gaseous exchange by respiratory system;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 6717, "hit_score": 0.2, "record_id": "Q6EV76-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IFT6-1", "uniprot_id": [ { "id": "ANO7_RAT", "url": "https://www.uniprot.org/uniprot/Q6IFT6", "type": "external" } ], "mass": 97170.0, "length": 860, "protein_name": "Anoctamin-7", "gene_name": "Ano7", "organism": "Rat", "refseq_name": "anoctamin-7", "refseq_ac": [ { "id": "NP_001004071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004071", "type": "external" } ], "gene_names_uniprotkb": "Ano7; Ngep; Tmem16g", "gene_names_refseq": "Ano7; Ngep; Tmem16g", "protein_names_uniprotkb": "Anoctamin-7; New gene expressed in prostate homolog; Transmembrane protein 16G", "protein_names_refseq": "anoctamin-7-like; anoctamin-7; transmembrane protein 16G", "tax_id": 10116, "disease": "", "pathway": " (rno:367318); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "14981236", "class_list": "", "function": "Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). May play a role in cell-cell interactions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0061589 calcium activated phosphatidylserine scrambling;GO:0061590 calcium activated phosphatidylcholine scrambling;GO:0061591 calcium activated galactosylceramide scrambling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IFT6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6T5-1", "uniprot_id": [ { "id": "OCLN_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6T5", "type": "external" } ], "mass": 59186.0, "length": 523, "protein_name": "Occludin", "gene_name": "Ocln", "organism": "Rat", "refseq_name": "occludin", "refseq_ac": [ { "id": "NP_112619", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112619", "type": "external" } ], "gene_names_uniprotkb": "Ocln", "gene_names_refseq": "Ocln", "protein_names_uniprotkb": "Occludin", "protein_names_refseq": "occludin", "tax_id": 10116, "disease": "", "pathway": " (rno:83497); (R-RNO-351906)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11751462;11810420;21454685;22673903;32716860;32807750;33343804;34359845;35908134", "class_list": "", "function": "Function and Biomarkers of the Blood-Brain Barrier in a Neonatal Germinal Matrix Haemorrhage Model. Publication Status: Online-Only, [RefSeq, PubMed]; Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1., [RefSeq, PubMed]; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. May be involved in the organization of actin in endothelial cells., [UniProtKB, PubMed]; Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development. Erratum:[Oxid Med Cell Longev. 2026 Feb 12;2026:9871853. doi: 10.1155/omcl/9871853. PMID: 41694329] Publication Status: Online-Only, [RefSeq, PubMed]; Present in the junctions of the olfactory epithelium, and in the endothelial cells in the blood vessels in the lamina propria of the olfactory mucosa, [RefSeq, PubMed]; Tear film instability is associated with weakened colocalization between occludin and MUC5AC in scopolamine-induced dry eye disease (DED) rats., [RefSeq, PubMed]; The magnitude of physical exercise-induced hyperthermia is associated with changes in the intestinal permeability and expression of tight junction genes in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z303", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0030054 cell junction", "go_biological_process": "GO:0010631 epithelial cell migration;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0045471 response to ethanol;GO:0090303 positive regulation of wound healing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6P6T5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7B4-1", "uniprot_id": [ { "id": "GAK1B_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7B4", "type": "external" } ], "mass": 58206.0, "length": 516, "protein_name": "Golgi-associated kinase 1B", "gene_name": "Gask1b", "organism": "Rat", "refseq_name": "Golgi-associated kinase 1B", "refseq_ac": [ { "id": "NP_954536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954536", "type": "external" } ], "gene_names_uniprotkb": "Gask1b; Ened; Fam198b", "gene_names_refseq": "Ened; Fam198b; Gask1b", "protein_names_uniprotkb": "Golgi-associated kinase 1B; Expressed in nerve and epithelium during development; Protein Fam198b", "protein_names_refseq": "Golgi-associated kinase 1B; expressed in nerve and epithelium during development; family with sequence similarity 198, member B; protein ENED; protein FAM198B", "tax_id": 10116, "disease": "", "pathway": " (rno:310540)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P7B4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7Q0-1", "uniprot_id": [ { "id": "ETKMT_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7Q0", "type": "external" } ], "mass": 28641.0, "length": 255, "protein_name": "Electron transfer flavoprotein beta subunit lysine methyltransferase", "gene_name": "Etfbkmt", "organism": "Rat", "refseq_name": "electron transfer flavoprotein beta subunit lysine methyltransferase", "refseq_ac": [ { "id": "NP_942067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942067", "type": "external" } ], "gene_names_uniprotkb": "Etfbkmt; Mettl20", "gene_names_refseq": "ETFB-KMT; Etfbkmt; Mettl20", "protein_names_uniprotkb": "Electron transfer flavoprotein beta subunit lysine methyltransferase; 2.1.1.-; ETFB lysine methyltransferase; ETFB-KMT; Protein N-lysine methyltransferase METTL20", "protein_names_refseq": "ETFB lysine methyltransferase; electron transfer flavoprotein beta subunit lysine methyltransferase; methyltransferase like 20; methyltransferase-like protein 20; protein N-lysine methyltransferase METTL20", "tax_id": 10116, "disease": "", "pathway": " (rno:316976); (R-RNO-8876725)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" } ], "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0032991 protein-containing complex", "go_biological_process": "GO:1904736 negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0018023 peptidyl-lysine trimethylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P7Q0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9U3-1", "uniprot_id": [ { "id": "COMD3_RAT", "url": "https://www.uniprot.org/uniprot/Q6P9U3", "type": "external" } ], "mass": 21932.0, "length": 195, "protein_name": "COMM domain-containing protein 3", "gene_name": "Commd3", "organism": "Rat", "refseq_name": "COMM domain-containing protein 3", "refseq_ac": [ { "id": "NP_942027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942027", "type": "external" } ], "gene_names_uniprotkb": "Commd3", "gene_names_refseq": "Commd3", "protein_names_uniprotkb": "COMM domain-containing protein 3", "protein_names_refseq": "COMM domain-containing protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:291339); (R-RNO-6798695); (R-RNO-8951664)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23637203", "class_list": "", "function": "Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (By similarity). May down-regulate activation of NF-kappa-B (By similarity). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (By similarity)., [UniProtKB, UniProtKB]; Suggest that COMMD3 and COMMD9 may be endogenous regulators of ENaC to regulate Na+ transport through altering ENaC cell surface expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6P9U3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PEC0-1", "uniprot_id": [ { "id": "AP4A_RAT", "url": "https://www.uniprot.org/uniprot/Q6PEC0", "type": "external" } ], "mass": 16929.0, "length": 147, "protein_name": "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]", "gene_name": "Nudt2", "organism": "Rat", "refseq_name": "bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]", "refseq_ac": [ { "id": "NP_997479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997479", "type": "external" } ], "gene_names_uniprotkb": "Nudt2", "gene_names_refseq": "Nudt2", "protein_names_uniprotkb": "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; 3.6.1.17; Ap4A hydrolase; Ap4Aase; Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; Diadenosine tetraphosphatase; Nucleoside diphosphate-linked moiety X motif 2; Nudix motif 2", "protein_names_refseq": "ap4A hydrolase; ap4Aase; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; bis(5'-nucleosyl)-tetraphosphatase; diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; diadenosine tetraphosphatase; nucleoside diphosphate-linked moiety X motif 2; nudix (nucleoside diphosphate linked moiety X)-type motif 2; nudix motif 2", "tax_id": 10116, "disease": "", "pathway": " (rno:297998); (R-RNO-3299685)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18644867", "class_list": "", "function": "Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity). Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Evidence provided that Ap(4)A hydrolase is responsible for Ap(4)A degradation following immunologic activation of mast cells; observations show involvement of Ap(4)A hydrolase in gene regulation can also occur in activated cardiac cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" }, { "id": "3.6.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.64", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "3.6.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.17", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity", "go_cellular_component": "", "go_biological_process": "GO:0006754 ATP biosynthetic process;GO:0006167 AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6PEC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q0N2-1", "uniprot_id": [ { "id": "FA89A_RAT", "url": "https://www.uniprot.org/uniprot/Q6Q0N2", "type": "external" } ], "mass": 18593.0, "length": 176, "protein_name": "Protein FAM89A", "gene_name": "Fam89a", "organism": "Rat", "refseq_name": "protein FAM89A", "refseq_ac": [ { "id": "NP_001011711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011711", "type": "external" } ], "gene_names_uniprotkb": "Fam89a", "gene_names_refseq": "Fam89a; RGD1309879", "protein_names_uniprotkb": "Protein FAM89A", "protein_names_refseq": "protein FAM89A", "tax_id": 10116, "disease": "", "pathway": " (rno:361441)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15326124", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6Q0N2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QDP7-1", "uniprot_id": [ { "id": "CR3L2_RAT", "url": "https://www.uniprot.org/uniprot/Q6QDP7", "type": "external" } ], "mass": 57379.0, "length": 521, "protein_name": "Cyclic AMP-responsive element-binding protein 3-like protein 2", "gene_name": "Creb3l2", "organism": "Rat", "refseq_name": "cyclic AMP-responsive element-binding protein 3-like protein 2", "refseq_ac": [ { "id": "NP_001012188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012188", "type": "external" } ], "gene_names_uniprotkb": "Creb3l2; Ra69", "gene_names_refseq": "Creb3l2; Ra69; SCIRR69", "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 3-like protein 2; SCI-related protein Ra69; cAMP-responsive element-binding protein 3-like protein 2", "protein_names_refseq": "SCI-related protein Ra69; cAMP-responsive element-binding protein 3-like protein 2; cyclic AMP-responsive element-binding protein 3-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:362339)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22535319;23842743;27488499;31597097;37555472", "class_list": "", "function": "CREB3L2 Regulates Hemidesmosome Formation during Epithelial Sealing., [RefSeq, PubMed]; Promotion of Axon Growth by the Secreted End of a Transcription Factor., [RefSeq, PubMed]; SCIRR69 functioned as a transcriptional activator and its N-terminal 60 amino acids accounted for the activation ability., [RefSeq, PubMed]; SCIRR69 is widely distributed in the central nervous system. After mechanical injury, it was induced, cleaved, and translocated to the nucleus. It bound BDNF promoter II and is involved in its expression., [RefSeq, PubMed]; SCIRR69 was expressed in response to ER stress at mRNA and protein levels. Its expression pattern was largely consistent with those of ER stress marker (ATF6, BIP and CHOP) at either mRNA level or protein level, implying that SCIRR69 may play important roles in ER stress. Transitional endoplasmic reticulum ATPase (TERA) and sideroflexin-1 (SFXN1) were potential SCIRR69-interacting proteins., [RefSeq, PubMed]; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0035497 cAMP response element binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0010976 positive regulation of neuron projection development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6QDP7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6SKG1-1", "uniprot_id": [ { "id": "ACSM3_RAT", "url": "https://www.uniprot.org/uniprot/Q6SKG1", "type": "external" } ], "mass": 65713.0, "length": 580, "protein_name": "Acyl-coenzyme A synthetase ACSM3, mitochondrial", "gene_name": "Acsm3", "organism": "Rat", "refseq_name": "acyl-coenzyme A synthetase ACSM3, mitochondrial", "refseq_ac": [ { "id": "NP_150234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_150234", "type": "external" } ], "gene_names_uniprotkb": "Acsm3; Sah", "gene_names_refseq": "Acsm3; Sah; Sa", "protein_names_uniprotkb": "Acyl-coenzyme A synthetase ACSM3, mitochondrial; 6.2.1.17; 6.2.1.2; Acyl-CoA synthetase medium-chain family member 3; Butyrate--CoA ligase 3; Butyryl-coenzyme A synthetase 3; Middle-chain acyl-CoA synthetase 3; Propionate--CoA ligase; Protein SA; SA rat hypertension-associated protein", "protein_names_refseq": "SA hypertension-associated homolog; SA rat hypertension-associated homolog; SA rat hypertension-associated protein; acyl-coenzyme A synthetase ACSM3, mitochondrial; butyrate--CoA ligase 3; butyryl-coenzyme A synthetase 3; middle-chain acyl-CoA synthetase 3; propionate--CoA ligase; protein SA; ssubA", "tax_id": 10116, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); hypertension (Disease Ontology:DOID:10763); IgA glomerulonephritis (Disease Ontology:DOID:2986); ulcerative colitis (Disease Ontology:DOID:8577); ocular hypertension (Disease Ontology:DOID:9282)", "pathway": " (rno:24763)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14739236;33923085;8535086", "class_list": "", "function": "Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms (By similarity)., [UniProtKB, UniProtKB]; Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62742", "ec_number_list": [ { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004321 fatty-acyl-CoA synthase activity;GO:0015645 fatty acid ligase activity;GO:0018729 propionate CoA-transferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6SKG1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6UPE1-1", "uniprot_id": [ { "id": "ETFD_RAT", "url": "https://www.uniprot.org/uniprot/Q6UPE1", "type": "external" } ], "mass": 68164.0, "length": 616, "protein_name": "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial", "gene_name": "Etfdh", "organism": "Rat", "refseq_name": "electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_942037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942037", "type": "external" } ], "gene_names_uniprotkb": "Etfdh", "gene_names_refseq": "Etfdh", "protein_names_uniprotkb": "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; 1.5.5.1; ETF dehydrogenase; ETF-QO; ETF-ubiquinone oxidoreductase; Electron-transferring-flavoprotein dehydrogenase", "protein_names_refseq": "ETF dehydrogenase; ETF-QO; ETF-ubiquinone oxidoreductase; electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor; electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; electron transferring flavoprotein dehydrogenase", "tax_id": 10116, "disease": "multiple acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0060358)", "pathway": " (rno:295143); (R-RNO-611105)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16248429;21428728;22673903", "class_list": "", "function": "Accepts electrons from ETF and reduces ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Links fatty acid beta-oxidation and amino acid catabolism to the respiratory chain by transferring electrons from the electron transfer flavoprotein (ETF) to ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.5.1", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0022900 electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6UPE1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71HP2-1", "uniprot_id": [ { "id": "GASP3_RAT", "url": "https://www.uniprot.org/uniprot/Q71HP2", "type": "external" } ], "mass": 59718.0, "length": 539, "protein_name": "G protein-coupled receptor associated sorting protein 3", "gene_name": "Gprasp3", "organism": "Rat", "refseq_name": "G protein-coupled receptor associated sorting protein 3", "refseq_ac": [ { "id": "NP_997494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997494", "type": "external" } ], "gene_names_uniprotkb": "Gprasp3; Bhlhb9", "gene_names_refseq": "Bhlhb9; Gprasp3; KKPROT; p60TRP", "protein_names_uniprotkb": "G protein-coupled receptor associated sorting protein 3; Protein BHLHb9; Transcription regulator of 60 kDa; bHLHb9; p60TRP", "protein_names_refseq": "G protein-coupled receptor associated sorting protein 3; basic helix-loop-helix domain containing, class B, 9; basic helix-loop-helix family member B9; protein BHLHB9; transcription regulator of 60 kDa", "tax_id": 10116, "disease": "", "pathway": " (rno:317407)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15034937;29393594", "class_list": "", "function": "Survival and differentiation promoting protein that plays a role in the regulation of neurosynaptogenesis. Induces phosphatase PP2A activity which results in APP dephosphorylation and inhibits BACE1-mediated processing of APP., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007611 learning or memory;GO:0043524 negative regulation of neuron apoptotic process;GO:0051965 positive regulation of synapse assembly;GO:0061003 positive regulation of dendritic spine morphogenesis;GO:0050769 positive regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q71HP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q75NT5-1", "uniprot_id": [ { "id": "AHRR_RAT", "url": "https://www.uniprot.org/uniprot/Q75NT5", "type": "external" } ], "mass": 77799.0, "length": 701, "protein_name": "Aryl hydrocarbon receptor repressor", "gene_name": "Ahrr", "organism": "Rat", "refseq_name": "aryl hydrocarbon receptor repressor", "refseq_ac": [ { "id": "NP_001019456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019456", "type": "external" } ], "gene_names_uniprotkb": "Ahrr", "gene_names_refseq": "Ahrr", "protein_names_uniprotkb": "Aryl hydrocarbon receptor repressor; AhR repressor; AhRR", "protein_names_refseq": "ahR repressor; aryl hydrocarbon receptor repressor", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:498999); (R-RNO-211945); (R-RNO-211976); (R-RNO-211981); (R-RNO-8937144)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "15013435;16595894;28485216", "class_list": "", "function": "Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with AHR for heterodimer formation with ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of a variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site., [UniProtKB, PubMed]; The constitutive expression of AhRR mRNA was prominent in males when compared with females in parallel with the sexual difference in AhR, [RefSeq, PubMed]; The expression of AHRR was upregulated in the kidneys of rats with chronic kidney disease., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0034751 aryl hydrocarbon receptor complex", "go_biological_process": "GO:0046209 nitric oxide metabolic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q75NT5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76JQ2-1", "uniprot_id": [ { "id": "FLCN_RAT", "url": "https://www.uniprot.org/uniprot/Q76JQ2", "type": "external" } ], "mass": 64122.0, "length": 579, "protein_name": "Folliculin", "gene_name": "Flcn", "organism": "Rat", "refseq_name": "folliculin", "refseq_ac": [ { "id": "NP_955422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955422", "type": "external" } ], "gene_names_uniprotkb": "Flcn; Bhd", "gene_names_refseq": "Bhd; Flcn", "protein_names_uniprotkb": "Folliculin; Birt-Hogg-Dube syndrome protein homolog", "protein_names_refseq": "birt-Hogg-Dube syndrome protein homolog; folliculin", "tax_id": 10116, "disease": "nonpapillary renal cell carcinoma (Disease Ontology:DOID:0050387); Birt-Hogg-Dube syndrome (Disease Ontology:DOID:0050676); primary spontaneous pneumothorax (Disease Ontology:DOID:0080218); renal cell carcinoma (Disease Ontology:DOID:4450); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:303185); (R-RNO-9639288)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14769940;16447066;22673903", "class_list": "", "function": "A germ-line mutation in the BHD gene caused by the insertion of a single nucleotide in the Nihon rat, results in a frameshift and produces a stop codon 26 aa downstream; the homozygous mutant condition was lethal at an early stage of fetal life, [RefSeq, PubMed]; Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis (By similarity). GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (By similarity). Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1 (By similarity). The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients (By similarity). Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1 (By similarity). In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3 (By similarity). Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3 (By similarity). Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling (By similarity). Involved in the control of embryonic stem cells differentiation; together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation (By similarity). Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3 (By similarity). In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation (By similarity). Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (By similarity). Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34 (By similarity). Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The Nihon rat is a useful tool for analyzing the events leading to renal tumorigenesis and for studying BHD gene functions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0005096 GTPase activator activity;GO:0019899 enzyme binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1901874 negative regulation of post-translational protein modification;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q76JQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76MT4-1", "uniprot_id": [ { "id": "ESF1_RAT", "url": "https://www.uniprot.org/uniprot/Q76MT4", "type": "external" } ], "mass": 97534.0, "length": 842, "protein_name": "ESF1 homolog", "gene_name": "Esf1", "organism": "Rat", "refseq_name": "ESF1 homolog", "refseq_ac": [ { "id": "NP_001094241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094241", "type": "external" } ], "gene_names_uniprotkb": "Esf1; Abtap", "gene_names_refseq": "Esf1; RGD1306067", "protein_names_uniprotkb": "ESF1 homolog; ABT1-associated protein", "protein_names_refseq": "ABT1-associated protein; ESF1 homolog; ESF1 nucleolar pre-rRNA processing protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:366203)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15660422;22673903", "class_list": "", "function": "May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q76MT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q78P75-1", "uniprot_id": [ { "id": "DYL2_RAT", "url": "https://www.uniprot.org/uniprot/Q78P75", "type": "external" } ], "mass": 10350.0, "length": 89, "protein_name": "Dynein light chain 2, cytoplasmic", "gene_name": "Dynll2", "organism": "Rat", "refseq_name": "dynein light chain 2, cytoplasmic", "refseq_ac": [ { "id": "NP_542428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542428", "type": "external" } ], "gene_names_uniprotkb": "Dynll2; Dlc2", "gene_names_refseq": "Dlc2; Dynll2", "protein_names_uniprotkb": "Dynein light chain 2, cytoplasmic; Dynein light chain LC8-type 2", "protein_names_refseq": "dynein light chain 2, cytoplasmic; dynein light chain-2", "tax_id": 10116, "disease": "", "pathway": " (rno:140734); (R-RNO-139910); (R-RNO-141430); (R-RNO-141444); (R-RNO-1632852); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3371497); (R-RNO-5620924); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811436); (R-RNO-68877); (R-RNO-9646399); (R-RNO-9648025)", "pathway_count": 16, "publication_count": 6, "publication_id_list": "11602781;11746667;12097491;12904292;16133941;26344333", "class_list": "", "function": "Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity)., [UniProtKB]; Results suggest that feeding increases excitatory synaptic input on paraventricular nucleus oxytocin neurons via mechanisms involving DYNLL2 upregulation and NMDA receptor-mediated synaptic reorganization., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0097110 scaffold protein binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0031475 myosin V complex;GO:0005813 centrosome;GO:0005856 cytoskeleton;GO:0005874 microtubule", "go_biological_process": "GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q78P75-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNN2-1", "uniprot_id": [ { "id": "COX8C_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNN2", "type": "external" } ], "mass": 8073.0, "length": 72, "protein_name": "Cytochrome c oxidase subunit 8C, mitochondrial", "gene_name": "Cox8c", "organism": "Rat", "refseq_name": "cytochrome c oxidase subunit 8C, mitochondrial", "refseq_ac": [ { "id": "NP_898878", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898878", "type": "external" } ], "gene_names_uniprotkb": "Cox8c", "gene_names_refseq": "COXVIII-3; Cox8c", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 8C, mitochondrial; COX VIII-3; Cytochrome c oxidase polypeptide 8 isoform 3; Cytochrome c oxidase polypeptide VIII isoform 3; Cytochrome c oxidase subunit 8-3", "protein_names_refseq": "COX VIII-3; cytochrome c oxidase polypeptide 8; cytochrome c oxidase polypeptide VIII; cytochrome c oxidase subunit 8-3; cytochrome c oxidase subunit 8C, mitochondrial; cytochrome c oxidase subunit VIII; cytochrome c oxidase, subunit VIIIc", "tax_id": 10116, "disease": "", "pathway": " (rno:360229); (R-RNO-5628897); (R-RNO-611105); (R-RNO-9707564)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "12909344", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TNN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TP52-1", "uniprot_id": [ { "id": "CMBL_RAT", "url": "https://www.uniprot.org/uniprot/Q7TP52", "type": "external" } ], "mass": 27903.0, "length": 245, "protein_name": "Carboxymethylenebutenolidase homolog", "gene_name": "Cmbl", "organism": "Rat", "refseq_name": "carboxymethylenebutenolidase homolog", "refseq_ac": [ { "id": "NP_001008770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008770", "type": "external" } ], "gene_names_uniprotkb": "Cmbl; Ab2-225", "gene_names_refseq": "Cmbl; RGD1306952", "protein_names_uniprotkb": "Carboxymethylenebutenolidase homolog; 3.1.-.-; Liver regeneration-related protein LRRG072", "protein_names_refseq": "Ab2-225; carboxymethylenebutenolidase homolog (Pseudomonas); carboxymethylenebutenolidase homolog; liver regeneration-related protein LRRG072", "tax_id": 10116, "disease": "", "pathway": " (rno:310201); (R-RNO-211945)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cysteine hydrolase whose endogenous substrates and physiological function are unknown. In vitro, catalyzes the hydrolytic activation of several ester-based prodrugs, by cleaving the dioxolone ring to yield their respective active metabolites, diacetyl and CO2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TP52-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSL3-1", "uniprot_id": [ { "id": "FBX11_RAT", "url": "https://www.uniprot.org/uniprot/Q7TSL3", "type": "external" } ], "mass": 94042.0, "length": 843, "protein_name": "F-box only protein 11", "gene_name": "Fbxo11", "organism": "Rat", "refseq_name": "F-box only protein 11", "refseq_ac": [ { "id": "NP_853662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853662", "type": "external" } ], "gene_names_uniprotkb": "Fbxo11", "gene_names_refseq": "Fbxo11; Vit1", "protein_names_uniprotkb": "F-box only protein 11", "protein_names_refseq": "F-box only protein 11-like; F-box only protein 11", "tax_id": 10116, "disease": "intellectual developmental disorder with dysmorphic facies and behavioral abnormalities (Disease Ontology:DOID:0061129); stomach cancer (Disease Ontology:DOID:10534); otitis media (Disease Ontology:DOID:10754); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:301674); (R-RNO-8951664); (R-RNO-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis. Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks. Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta. Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome. Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis. Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016274 protein-arginine N-methyltransferase activity;GO:0004842 ubiquitin-protein transferase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:1904878 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0007605 sensory perception of sound;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TSL3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZF0-1", "uniprot_id": [ { "id": "CORA1_RAT", "url": "https://www.uniprot.org/uniprot/Q80ZF0", "type": "external" } ], "mass": 187812.0, "length": 1855, "protein_name": "Collagen alpha-1(XXVII) chain", "gene_name": "Col27a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Col27a1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(XXVII) chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:298101); (R-RNO-1650814); (R-RNO-2022090); (R-RNO-8874081); (R-RNO-8948216)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role during the calcification of cartilage and the transition of cartilage to bone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005583 fibrillar collagen trimer;GO:0005576 extracellular region", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0001501 skeletal system development;GO:0003431 growth plate cartilage chondrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q80ZF0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810H6-1", "uniprot_id": [ { "id": "DISC1_RAT", "url": "https://www.uniprot.org/uniprot/Q810H6", "type": "external" } ], "mass": 92563.0, "length": 846, "protein_name": "Disrupted in schizophrenia 1 homolog", "gene_name": "Disc1", "organism": "Rat", "refseq_name": "disrupted in schizophrenia 1 homolog", "refseq_ac": [ { "id": "NP_783186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783186", "type": "external" } ], "gene_names_uniprotkb": "Disc1", "gene_names_refseq": "Disc1", "protein_names_uniprotkb": "Disrupted in schizophrenia 1 homolog", "protein_names_refseq": "disrupted in schizophrenia 1 homolog", "tax_id": 10116, "disease": "Asperger syndrome (Disease Ontology:DOID:0050432); schizophrenia 9 (Disease Ontology:DOID:0070085); autistic disorder (Disease Ontology:DOID:12849); major depressive disorder (Disease Ontology:DOID:1470); melancholic depression (Disease Ontology:DOID:1595); psychotic disorder (Disease Ontology:DOID:2468); substance-related disorder (Disease Ontology:DOID:303); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); chronic fatigue syndrome (Disease Ontology:DOID:8544)", "pathway": " (rno:307940)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12506198;12874605;17035248;17389905;30745562;31103832;33960643;35461978;35715502", "class_list": "", "function": "DISC1 participates in neurite outgrowth through its interaction with FEZ1., [RefSeq, PubMed]; Disrupted-in-schizophrenia 1 Protein Misassembly Impairs Cognitive Flexibility and Social Behaviors in a Transgenic Rat Model., [RefSeq, PubMed]; Global and sex-specific changes in white matter microstructural integrity and deficits in neurite density as a consequence of the Disc1 svDelta2 genetic variation Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:17035248). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Mutations of the DISC1 gene have been implicated in the molecular intersection of schizophrenia and numerous other major psychiatric illnesses., [RefSeq, PubMed]; Progression of behavioral deficits during periadolescent development differs in female and male DISC1 knockout rats., [RefSeq, PubMed]; Social anhedonia as a Disrupted-in-Schizophrenia 1-dependent phenotype. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0008092 cytoskeletal protein binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0001764 neuron migration;GO:0050965 detection of temperature stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q810H6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811X5-1", "uniprot_id": [ { "id": "EAF2_RAT", "url": "https://www.uniprot.org/uniprot/Q811X5", "type": "external" } ], "mass": 28933.0, "length": 262, "protein_name": "ELL-associated factor 2", "gene_name": "Eaf2", "organism": "Rat", "refseq_name": "ELL-associated factor 2", "refseq_ac": [ { "id": "NP_742044", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742044", "type": "external" } ], "gene_names_uniprotkb": "Eaf2; Traits", "gene_names_refseq": "Eaf2; Traits", "protein_names_uniprotkb": "ELL-associated factor 2; Testosterone-regulated apoptosis inducer and tumor suppressor protein", "protein_names_refseq": "ELL-associated factor 2; testosterone regulated apoptosis inducer and tumor suppressor; testosterone-regulated apoptosis inducer and tumor suppressor protein; transcription factor", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:266787); (R-RNO-112382); (R-RNO-674695); (R-RNO-75955)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "12907652", "class_list": "", "function": "Acts as a transcriptional transactivator of ELL, ELL2 and TCEA1 elongation activities (By similarity). Potent inducer of apoptosis in prostatic and non-prostatic cell lines., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex;GO:0016607 nuclear speck;GO:0032783 super elongation complex", "go_biological_process": "GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q811X5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGZ2-1", "uniprot_id": [ { "id": "ADIP_RAT", "url": "https://www.uniprot.org/uniprot/Q8CGZ2", "type": "external" } ], "mass": 70679.0, "length": 613, "protein_name": "Afadin- and alpha-actinin-binding protein", "gene_name": "Ssx2ip", "organism": "Rat", "refseq_name": "afadin- and alpha-actinin-binding protein", "refseq_ac": [ { "id": "NP_783187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783187", "type": "external" } ], "gene_names_uniprotkb": "Ssx2ip", "gene_names_refseq": "ADIP; Ssx2ip", "protein_names_uniprotkb": "Afadin- and alpha-actinin-binding protein; ADIP; Afadin DIL domain-interacting protein", "protein_names_refseq": "afadin DIL domain-interacting protein; afadin- and alpha-actinin-binding protein ADIP; afadin- and alpha-actinin-binding protein-like; afadin- and alpha-actinin-binding protein; synovial sarcoma, X breakpoint 2 interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:308023)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12446711;15358183;22673903;25712270", "class_list": "", "function": "ADIP is involved in vesicle trafficking from the Golgi to the endoplasmic reticulum, [RefSeq, PubMed]; Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (PubMed:12446711). Involved in ciliogenesis (By similarity). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Afadin mediates RhoA/ROCK signaling and contributes to the formation of actin stress fibers in podocyte cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005912 adherens junction;GO:0031252 cell leading edge;GO:0034451 centriolar satellite", "go_biological_process": "GO:0007155 cell adhesion;GO:2000145 regulation of cell motility;GO:0030036 actin cytoskeleton organization;GO:0060271 cilium assembly;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CGZ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3U6-1", "uniprot_id": [ { "id": "FA7_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3U6", "type": "external" } ], "mass": 50399.0, "length": 446, "protein_name": "Coagulation factor VII", "gene_name": "F7", "organism": "Rat", "refseq_name": "coagulation factor VII precursor", "refseq_ac": [ { "id": "NP_690059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690059", "type": "external" } ], "gene_names_uniprotkb": "F7", "gene_names_refseq": "F7", "protein_names_uniprotkb": "Coagulation factor VII; 3.4.21.21; Serum prothrombin conversion accelerator", "protein_names_refseq": "coagulation factor VII precursor; serum prothrombin conversion accelerator", "tax_id": 10116, "disease": "acquired angioedema (Disease Ontology:DOID:0080941); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); hypothyroidism (Disease Ontology:DOID:1459); hereditary angioedema (Disease Ontology:DOID:14735); thrombocytopenia (Disease Ontology:DOID:1588); breast cancer (Disease Ontology:DOID:1612); factor VII deficiency (Disease Ontology:DOID:2215); prothrombin deficiency (Disease Ontology:DOID:2235); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); bilirubin metabolic disorder (Disease Ontology:DOID:2741); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); hyperglycemia (Disease Ontology:DOID:4195); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:260320); (R-RNO-159740); (R-RNO-159763); (R-RNO-159782); (R-RNO-9769735); (R-RNO-9769739)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" }, { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" }, { "id": "3.4.21.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0031982 vesicle;GO:0032991 protein-containing complex;GO:1905286 serine-type peptidase complex", "go_biological_process": "GO:0097068 response to thyroxine;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0001666 response to hypoxia;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8K3U6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3V5-2", "uniprot_id": [ { "id": "FNDC5_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3V5", "type": "external" } ], "mass": 26442.0, "length": 240, "protein_name": "Fibronectin type III domain-containing protein 5", "gene_name": "Fndc5", "organism": "Rat", "refseq_name": "fibronectin type III domain-containing protein 5 precursor", "refseq_ac": [ { "id": "NP_001257910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257910", "type": "external" } ], "gene_names_uniprotkb": "Fndc5", "gene_names_refseq": "Fndc5", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 5", "protein_names_refseq": "fibronectin type III domain-containing protein 5 precursor; fibronectin type III domain-containing protein 5; peroxisomal protein", "tax_id": 10116, "disease": "", "pathway": " (rno:260327)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "23470775;23498898;36161624;36262283;36414561;38612728;38708500", "class_list": "", "function": "Early Movement Restriction Affects FNDC5/Irisin and BDNF Levels in Rat Muscle and Brain. Publication Status: Online-Only, [RefSeq, PubMed]; Further research is needed to examine whether other adipose tissue-derived factors up-regulate FNDC5 transcription and/or inhibit irisin biosynthesis from FNDC5, [RefSeq, PubMed]; Irisin Promotes Osteogenesis by Modulating Oxidative Stress and Mitophagy through SIRT3 Signaling under Diabetic Conditions. Publication Status: Online-Only, [RefSeq, PubMed]; Irisin relaxes rat thoracic aorta through inhibiting signaling pathways implicating protein kinase C., [RefSeq, PubMed]; Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA., [UniProtKB, UniProtKB]; This immunohistochemical results demonstrate the expression of irisin immunoreactivity in three types of cells: skeletal, cardiac muscle, and Purkinje cells of the cerebellum., [RefSeq, PubMed]; [Effects of different types of exercise on contractile properties and expressions of MuRF1, PGC-1alpha /FNDC5 in soleus muscle of unloaded rats]., [RefSeq, PubMed]; [Exercise promotes irisin expression to ameliorate renal injury in type 2 diabetic rats]., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A8L2QNJ9", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0014850 response to muscle activity;GO:0090336 positive regulation of brown fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8K3V5-2", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4D8-1", "uniprot_id": [ { "id": "AL1A3_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4D8", "type": "external" } ], "mass": 56171.0, "length": 512, "protein_name": "Retinaldehyde dehydrogenase 3", "gene_name": "Aldh1a3", "organism": "Rat", "refseq_name": "retinaldehyde dehydrogenase 3", "refseq_ac": [ { "id": "NP_695212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695212", "type": "external" } ], "gene_names_uniprotkb": "Aldh1a3; Aldh6; Raldh3", "gene_names_refseq": "Aldh1a3; Aldh6", "protein_names_uniprotkb": "Retinaldehyde dehydrogenase 3; 1.2.1.36; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; Aldh1a3; RALDH-3; RalDH3", "protein_names_refseq": "RALDH-3; aldehyde dehydrogenase 6; aldehyde dehydrogenase family 1 member A3; aldehyde dehydrogenase family 1, subfamily A3; ralDH3; retinaldehyde dehydrogenase 3", "tax_id": 10116, "disease": "isolated microphthalmia 8 (Disease Ontology:DOID:0060841)", "pathway": " (rno:266603); (R-RNO-5365859)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12390888", "class_list": "", "function": "Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (Probable). High specificity for all-trans-retinal as substrate, can also accept acetaldehyde as substrate in vitro but with lower affinity (By similarity). Required for the biosynthesis of normal levels of retinoate in the embryonic ocular and nasal regions; a critical lipid in the embryonic development of the eye and the nasal region (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity;GO:0070324 thyroid hormone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043584 nose development;GO:0007626 locomotory behavior;GO:0042472 inner ear morphogenesis;GO:0043065 positive regulation of apoptotic process;GO:0050885 neuromuscular process controlling balance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K4D8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K4I4-1", "uniprot_id": [ { "id": "BPIA1_RAT", "url": "https://www.uniprot.org/uniprot/Q8K4I4", "type": "external" } ], "mass": 27719.0, "length": 270, "protein_name": "BPI fold-containing family A member 1", "gene_name": "Bpifa1", "organism": "Rat", "refseq_name": "BPI fold-containing family A member 1 precursor", "refseq_ac": [ { "id": "NP_742028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742028", "type": "external" } ], "gene_names_uniprotkb": "Bpifa1; Plunc", "gene_names_refseq": "Bpifa1; Plunc", "protein_names_uniprotkb": "BPI fold-containing family A member 1; Palate lung and nasal epithelium clone protein", "protein_names_refseq": "BPI fold-containing family A member 1 precursor; ES cell-related protein; palate lung and nasal epithelium clone protein; palate, lung and nasal epithelium associated; palate, lung, and nasal epithelium carcinoma associated protein; palate, lung, and nasal epithelium expressed transcript; protein Plunc", "tax_id": 10116, "disease": "otitis media (Disease Ontology:DOID:10754)", "pathway": " (rno:246238); (R-RNO-6803157)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11821380", "class_list": "", "function": "Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005902 microvillus", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0043129 surfactant homeostasis;GO:0045087 innate immune response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0002675 positive regulation of acute inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8K4I4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K589-1", "uniprot_id": [ { "id": "BMF_RAT", "url": "https://www.uniprot.org/uniprot/Q8K589", "type": "external" } ], "mass": 20710.0, "length": 185, "protein_name": "Bcl-2-modifying factor", "gene_name": "Bmf", "organism": "Rat", "refseq_name": "bcl-2-modifying factor isoform 1", "refseq_ac": [ { "id": "NP_640351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_640351", "type": "external" } ], "gene_names_uniprotkb": "Bmf", "gene_names_refseq": "Bmf", "protein_names_uniprotkb": "Bcl-2-modifying factor", "protein_names_refseq": "Bcl-2 modifying factor; bcl-2-modifying factor isoform 1; bcl-2-modifying factor", "tax_id": 10116, "disease": "", "pathway": " (rno:246142); (R-RNO-139910)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12787069;14668207;18222916;27539959;31200256;36315357", "class_list": "", "function": "Activation of MAPK8 and redistribution of BMF may be integrally involved in the mechanism by which specific germ cells undergo programmed cell death in response to their detachment from Sertoli cells., [RefSeq, PubMed]; Bmf may well be involved in germ cell apoptosis and/or anoikis in response to decreased intratesticular testosterone concentration., [RefSeq, PubMed]; May play a role in apoptosis., [UniProtKB]; MiR-874-3p attenuated ischemic injury by negatively regulating BMF and BCL2L13., [RefSeq, PubMed]; Reciprocal regulation of BMF and BIRC5 is linked to Eomes overexpression in colorectal cancer., [RefSeq, PubMed]; Upregulation of miR-29b-3p alleviates coronary microembolization-induced myocardial injury via regulating BMF and GSK-3beta., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0001669 acrosomal vesicle;GO:0016459 myosin complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0031334 positive regulation of protein-containing complex assembly;GO:0010507 negative regulation of autophagy;GO:0090200 positive regulation of release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8K589-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4A1-1", "uniprot_id": [ { "id": "ERO1A_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4A1", "type": "external" } ], "mass": 54018.0, "length": 464, "protein_name": "ERO1-like protein alpha", "gene_name": "Ero1a", "organism": "Rat", "refseq_name": "ERO1-like protein alpha isoform 1 precursor", "refseq_ac": [ { "id": "NP_612537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612537", "type": "external" } ], "gene_names_uniprotkb": "Ero1a; Ero1l; Giig11", "gene_names_refseq": "Ero1a; Ero1l", "protein_names_uniprotkb": "ERO1-like protein alpha; 1.8.3.2; ERO1-L-alpha; ERO1-L; Endoplasmic reticulum oxidoreductase alpha; Endoplasmic reticulum oxidoreductin-1-like protein; Global ischemia-induced protein 11; Oxidoreductin-1-L-alpha", "protein_names_refseq": "ERO1-L-alpha; ERO1-L; ERO1-like protein alpha isoform 1 precursor; ERO1-like protein alpha; endoplasmic oxidoreductin-1-like protein; endoplasmic reticulum oxidoreductase alpha; endoplasmic reticulum oxidoreductin-1-like protein; global ischemia-induced protein 11; oxidoreductin-1-L-alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:171562); (R-RNO-3299685)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12694393;12752442;24090084;30058081;31176989;32626998;35086342", "class_list": "", "function": "Ero1alpha-Dependent ERp44 Dissociation From RyR2 Contributes to Cardiac Arrhythmia., [RefSeq, PubMed]; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1., [UniProtKB, UniProtKB]; Oxygen regulation of ERO1-Lalpha expression likely is to maintain the transfer rate of oxidizing equivalents to PDI in situations of an altered cellular redox state induced by changes of the cellular oxygen tension, [RefSeq, PubMed]; Riboflavin deficiency affects lipid metabolism partly by reducing apolipoprotein B100 synthesis in rats., [RefSeq, PubMed]; Role of endoplasmic reticulum oxidase 1alpha in H9C2 cardiomyocytes following hypoxia/reoxygenation injury., [RefSeq, PubMed]; These results demonstrate that the hypermethylation of ERO1alpha mediated by increased binding of DNMT1 to the ERO1alpha promoter leads to trophoblast cell apoptosis through ER stress in the placenta of preeclampsia rats., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 6, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8VH29;Q8VH30", "ec_number_list": [ { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0016491 oxidoreductase activity;GO:0015035 protein-disulfide reductase activity;GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0016972 thiol oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005796 Golgi lumen;GO:0030425 dendrite;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0030198 extracellular matrix organization;GO:0050873 brown fat cell differentiation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q8R4A1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4S8-1", "uniprot_id": [ { "id": "CRLF2_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4S8", "type": "external" } ], "mass": 38445.0, "length": 360, "protein_name": "Cytokine receptor-like factor 2", "gene_name": "Crlf2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Crlf2; Tslpr", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytokine receptor-like factor 2; TSLP receptor; Thymic stromal lymphopoietin protein receptor", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171499)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11891057", "class_list": "", "function": "Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5 (By similarity). Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0032754 positive regulation of interleukin-5 production;GO:0006954 inflammatory response;GO:0008284 positive regulation of cell population proliferation;GO:0019221 cytokine-mediated signaling pathway;GO:0033005 positive regulation of mast cell activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8R4S8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R5H8-1", "uniprot_id": [ { "id": "FAIM1_RAT", "url": "https://www.uniprot.org/uniprot/Q8R5H8", "type": "external" } ], "mass": 22705.0, "length": 201, "protein_name": "Fas apoptotic inhibitory molecule 1", "gene_name": "Faim", "organism": "Rat", "refseq_name": "fas apoptotic inhibitory molecule 1", "refseq_ac": [ { "id": "NP_543171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543171", "type": "external" } ], "gene_names_uniprotkb": "Faim; Faim1", "gene_names_refseq": "Faim", "protein_names_uniprotkb": "Fas apoptotic inhibitory molecule 1; rFAIM", "protein_names_refseq": "fas apoptotic inhibitory molecule 1", "tax_id": 10116, "disease": "", "pathway": " (rno:140930)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15520226;28383554", "class_list": "", "function": "Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells., [UniProtKB]; The anti-apoptotic effect of SRT1720 was mitigated by FAIM knockdown with a small interfering RNA-targeted FAIM. These results indicated that pretreatment with SRT1720 improves survival of aged hMSCs, and enhances their therapeutic efficacy for rat myocardial infarction (MI). Publication Status: Online-Only, [RefSeq, PubMed]; Whereas FAIM overexpression greatly enhanced neurite outgrowth from PC12 cells and sympathetic neurons grown with nerve growth factor, reduction of endogenous FAIM levels by RNAi decreased neurite outgrowth in these cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHR4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0050769 positive regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R5H8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VII0-1", "uniprot_id": [ { "id": "FRMD6_RAT", "url": "https://www.uniprot.org/uniprot/Q8VII0", "type": "external" } ], "mass": 38847.0, "length": 327, "protein_name": "FERM domain-containing protein 6", "gene_name": "Frmd6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Frmd6", "gene_names_refseq": "", "protein_names_uniprotkb": "FERM domain-containing protein 6; FERM domain-containing protein 163SCII", "protein_names_refseq": "", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:257646)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043296 apical junction complex", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0032970 regulation of actin filament-based process;GO:0003383 apical constriction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VII0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XQ2-1", "uniprot_id": [ { "id": "EPM2A_RAT", "url": "https://www.uniprot.org/uniprot/Q91XQ2", "type": "external" } ], "mass": 37144.0, "length": 331, "protein_name": "Laforin", "gene_name": "Epm2a", "organism": "Rat", "refseq_name": "laforin", "refseq_ac": [ { "id": "NP_001263691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263691", "type": "external" } ], "gene_names_uniprotkb": "Epm2a", "gene_names_refseq": "Epm2a", "protein_names_uniprotkb": "Laforin; 3.1.3.-; 3.1.3.16; 3.1.3.48; Glucan phosphatase; LAFPTPase; Lafora PTPase", "protein_names_refseq": "EPM2A, laforin glucan phosphatase; LAFPTPase; epilepsy, progressive myoclonic epilepsy, type 2 gene alpha; epilepsy, progressive myoclonus type 2A; glucan phosphatase; lafora PTPase; laforin", "tax_id": 10116, "disease": "Lafora disease 1 (Disease Ontology:DOID:0070660); Lafora disease (Disease Ontology:DOID:3534); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (rno:114005)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11355878", "class_list": "", "function": "Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro). Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LPW7", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046959 habituation;GO:0016311 dephosphorylation;GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0000045 autophagosome assembly;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91XQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920D2-1", "uniprot_id": [ { "id": "DYR_RAT", "url": "https://www.uniprot.org/uniprot/Q920D2", "type": "external" } ], "mass": 21638.0, "length": 187, "protein_name": "Dihydrofolate reductase", "gene_name": "Dhfr", "organism": "Rat", "refseq_name": "dihydrofolate reductase", "refseq_ac": [ { "id": "NP_569084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569084", "type": "external" } ], "gene_names_uniprotkb": "Dhfr", "gene_names_refseq": "Dhfr1; Dhfr", "protein_names_uniprotkb": "Dihydrofolate reductase; 1.5.1.3", "protein_names_refseq": "Dihydrofolate reductase 1 (active); dihydrofolate reductase", "tax_id": 10116, "disease": "spondyloepimetaphyseal dysplasia, Li-Shao-Li type (Disease Ontology:DOID:0051046); kyphomelic dysplasia (Disease Ontology:DOID:0061155); bone disease (Disease Ontology:DOID:0080001); primary biliary cholangitis (Disease Ontology:DOID:12236); endomyocardial fibrosis (Disease Ontology:DOID:12932); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); osteochondrodysplasia (Disease Ontology:DOID:2256); ovarian cancer (Disease Ontology:DOID:2394); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); restrictive cardiomyopathy (Disease Ontology:DOID:397); liver cirrhosis (Disease Ontology:DOID:5082); ureteral obstruction (Disease Ontology:DOID:5199); aortic valve insufficiency (Disease Ontology:DOID:57); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); tendinitis (Disease Ontology:DOID:971); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:24312); (R-RNO-196757)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11502523;25980602", "class_list": "", "function": "Catalyzes the reduction of 7,8-dihydrofolate (DHF) to 5,6,7,8-tetrahydrofolate in a NADPH-dependent manner. Key enzyme in folate metabolism (PubMed:25980602). Contributes to the nuclear and mitochondrial de novo thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in both rat and mouse but this is not due to a second enzyme, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 23, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.3", "type": "external" } ], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:1990825 sequence-specific mRNA binding;GO:0004146 dihydrofolate reductase activity;GO:0003729 mRNA binding;GO:0070402 NADPH binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005657 replication fork", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0035094 response to nicotine;GO:0006260 DNA replication;GO:0017148 negative regulation of translation;GO:0046655 folic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q920D2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920J3-1", "uniprot_id": [ { "id": "CORO6_RAT", "url": "https://www.uniprot.org/uniprot/Q920J3", "type": "external" } ], "mass": 52948.0, "length": 472, "protein_name": "Coronin-6", "gene_name": "Coro6", "organism": "Rat", "refseq_name": "coronin-6 isoform 1", "refseq_ac": [ { "id": "NP_620815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620815", "type": "external" } ], "gene_names_uniprotkb": "Coro6", "gene_names_refseq": "Coro6", "protein_names_uniprotkb": "Coronin-6", "protein_names_refseq": "clipin E; coronin relative protein; coronin, actin binding protein 6; coronin-6 isoform 1", "tax_id": 10116, "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:245982)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "24523531", "class_list": "", "function": "These findings demonstrate that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the neuromuscular junction, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G087", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q920J3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920L7-1", "uniprot_id": [ { "id": "ELOV5_RAT", "url": "https://www.uniprot.org/uniprot/Q920L7", "type": "external" } ], "mass": 35235.0, "length": 299, "protein_name": "Very long chain fatty acid elongase 5", "gene_name": "Elovl5", "organism": "Rat", "refseq_name": "very long chain fatty acid elongase 5", "refseq_ac": [ { "id": "NP_599209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599209", "type": "external" } ], "gene_names_uniprotkb": "Elovl5", "gene_names_refseq": "Elovl5; rELO1", "protein_names_uniprotkb": "Very long chain fatty acid elongase 5; 2.3.1.199; 3-keto acyl-CoA synthase Elovl5; ELOVL FA elongase 5; ELOVL fatty acid elongase 5; Elongation of very long chain fatty acids protein 5; Fatty acid elongase 1; Very long chain 3-ketoacyl-CoA synthase 5; Very long chain 3-oxoacyl-CoA synthase 5; rELO1", "protein_names_refseq": "3-keto acyl-CoA synthase Elovl5; ELOVL FA elongase 5; ELOVL family member 5, elongation of long chain fatty acids; elongation of long chain fatty acids family member 5; elongation of very long chain fatty acids protein 5; elongation of very long chain fatty acids-like 5; fatty acid elongase 1; very long chain 3-ketoacyl-CoA synthase 5; very long chain 3-oxoacyl-CoA synthase 5; very long chain fatty acid elongase 5", "tax_id": 10116, "disease": "spinocerebellar ataxia 38 (Disease Ontology:DOID:0050985)", "pathway": " (rno:171400); (R-RNO-2046105); (R-RNO-2046106); (R-RNO-75876)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "12005057;22216341;23873268;25046614", "class_list": "", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity) (PubMed:22216341, PubMed:23873268). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity)., [UniProtKB, HAMAP, UniProtKB, PubMed, PubMed]; Critical residues in Elovl2 and Elovl5 define their substrate specificities and their ability to elongate docosapentaenoic acid., [RefSeq, PubMed]; Results show that genes with the highest expression in the mammary gland, liver and adipose tissue were Elovl5, Fads2, and Fasn, respectively, in a low-lipid diet than in adequate-lipid diet., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G9BD46", "ec_number_list": [ { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" } ], "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0097447 dendritic tree;GO:0005783 endoplasmic reticulum;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0045723 positive regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q920L7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920M9-1", "uniprot_id": [ { "id": "SIAH1_RAT", "url": "https://www.uniprot.org/uniprot/Q920M9", "type": "external" } ], "mass": 31137.0, "length": 282, "protein_name": "E3 ubiquitin-protein ligase SIAH1", "gene_name": "Siah1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase SIAH1", "refseq_ac": [ { "id": "NP_543181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543181", "type": "external" } ], "gene_names_uniprotkb": "Siah1; Siah1a", "gene_names_refseq": "SIAH; Siah1a; Siah1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase SIAH1; 2.3.2.27; RING-type E3 ubiquitin transferase SIAH1; Seven in absentia homolog 1; Siah-1a; Siah-1", "protein_names_refseq": "E3 ubiquitin-protein ligase SIAH1; RING-type E3 ubiquitin transferase SIAH1; seven in absentia 1A; seven in absentia homolog 1; siah-1a; siah-1", "tax_id": 10116, "disease": "", "pathway": " (rno:140941); (R-RNO-983168)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10469171;11686852;11786535;15064394;15951807;19224863;23403927;25163685;27256506;31322210", "class_list": "", "function": "Binds group I metabotropic glutamate receptors and calmodulin; calmodulin binding may play a role in the regulation of group I mGluR function, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11786535, PubMed:15951807). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11786535, PubMed:15951807). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (PubMed:11786535, PubMed:15951807). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP (PubMed:11786535). Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity). It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription, spermatogenesis and TNF signaling (By similarity). Has some overlapping function with SIAH2 (By similarity). Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocation of GAPDH to the nucleus (PubMed:15951807). GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins (PubMed:15951807). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Study reveals GAPDH/Siah1 as a novel signaling pathway in apoptosis and function recovery after traumatic spinal cord injury. This signaling pathway in the spinal cord can be blocked by sivelestat sodium., [RefSeq, PubMed]; The results of this study indicated that CacyBP/SIP is a novel regulator of CRE- and NFAT-driven transcription., [RefSeq, PubMed]; These findings suggest that siah1 is involved in homocysteineinduced cell damage by promoting the nuclear translocation of glyceraldehyde 3phosphate dehydrogenase ., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q06984", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0040014 regulation of multicellular organism growth;GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q920M9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920R3-1", "uniprot_id": [ { "id": "FADS1_RAT", "url": "https://www.uniprot.org/uniprot/Q920R3", "type": "external" } ], "mass": 52482.0, "length": 447, "protein_name": "Acyl-CoA (8-3)-desaturase", "gene_name": "Fads1", "organism": "Rat", "refseq_name": "acyl-CoA (8-3)-desaturase", "refseq_ac": [ { "id": "NP_445897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445897", "type": "external" } ], "gene_names_uniprotkb": "Fads1", "gene_names_refseq": "Fads1", "protein_names_uniprotkb": "Acyl-CoA (8-3)-desaturase; 1.14.19.44; D5D; Delta(5) desaturase; Delta(5) fatty acid desaturase; Delta-5 desaturase; Fatty acid desaturase 1", "protein_names_refseq": "D5D; acyl-CoA (8-3)-desaturase; delta(5) desaturase; delta(5) fatty acid desaturase", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); lipid metabolism disorder (Disease Ontology:DOID:3146); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:84575); (R-RNO-2046105); (R-RNO-2046106)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11414679;19157821;22133376;24070791", "class_list": "", "function": "Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:24070791). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (PubMed:24070791)., [UniProtKB, PubMed, UniProtKB]; Data show that an imbalance of maternal micronutrients increases Delta5 desaturase activity but decreases mRNA levels, decreases Delta6 desaturase activity but not mRNA levels as compared to control., [RefSeq, PubMed]; Regulation of 5-desaturase expression is different in female vs. male liver (but not cerebral cortex) during n-3 fatty acid repletion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9EPV4", "ec_number_list": [ { "id": "1.14.19.44", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.44", "type": "external" } ], "go_molecular_function": "GO:0045485 omega-6 fatty acid desaturase activity;GO:0016491 oxidoreductase activity;GO:0016213 acyl-CoA 6-desaturase activity;GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water;GO:0062076 acyl-CoA (8-3)-desaturase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007584 response to nutrient;GO:0035900 response to isolation stress;GO:0006633 fatty acid biosynthetic process;GO:0033189 response to vitamin A", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q920R3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923I8-1", "uniprot_id": [ { "id": "CRY2_RAT", "url": "https://www.uniprot.org/uniprot/Q923I8", "type": "external" } ], "mass": 67223.0, "length": 594, "protein_name": "Cryptochrome-2", "gene_name": "Cry2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cry2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cryptochrome-2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "11804325;16790549", "class_list": "", "function": "Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. May mediate circadian regulation of cAMP signaling and gluconeogenesis by blocking glucagon-mediated increases in intracellular cAMP concentrations and in CREB1 phosphorylation. Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Represses the CLOCK-BMAL1 induced transcription of BHLHE40/DEC1 and NAMPT (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Represses the transcriptional activity of NR1I2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019901 protein kinase binding;GO:0071949 FAD binding;GO:0003684 damaged DNA binding;GO:0019900 kinase binding", "go_cellular_component": "GO:1990512 Cry-Per complex;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:2000850 negative regulation of glucocorticoid secretion;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q923I8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924T9-1", "uniprot_id": [ { "id": "CLTR2_RAT", "url": "https://www.uniprot.org/uniprot/Q924T9", "type": "external" } ], "mass": 35507.0, "length": 309, "protein_name": "Cysteinyl leukotriene receptor 2", "gene_name": "Cysltr2", "organism": "Rat", "refseq_name": "cysteinyl leukotriene receptor 2", "refseq_ac": [ { "id": "NP_596904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596904", "type": "external" } ], "gene_names_uniprotkb": "Cysltr2; Cyslt2", "gene_names_refseq": "Cyslt2; Cysltr2; RSBPT32", "protein_names_uniprotkb": "Cysteinyl leukotriene receptor 2; CysLTR2; RSBPT32", "protein_names_refseq": "cysteinyl leukotriene CysLT2 receptor; cysteinyl leukotriene receptor 2", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483)", "pathway": " (rno:170926); (R-RNO-391906); (R-RNO-416476)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "21664436", "class_list": "", "function": "Receptor for cysteinyl leukotrienes. The response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system (By similarity)., [UniProtKB]; The spatiotemporal profiles of CysLT2 receptor expression suggest that it plays regulatory roles in acute neuron injury, and astrocytosis and microgliosis in the late phase., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001631 cysteinyl leukotriene receptor activity;GO:0004966 galanin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0045766 positive regulation of angiogenesis;GO:0071456 cellular response to hypoxia;GO:0060253 negative regulation of glial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q924T9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925N7-1", "uniprot_id": [ { "id": "CL2D5_RAT", "url": "https://www.uniprot.org/uniprot/Q925N7", "type": "external" } ], "mass": 25686.0, "length": 233, "protein_name": "C-type lectin domain family 2 member D5", "gene_name": "Ocil", "organism": "Rat", "refseq_name": "C-type lectin domain family 2 member D5", "refseq_ac": [ { "id": "NP_569086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569086", "type": "external" } ], "gene_names_uniprotkb": "Ocil; Clec2d5", "gene_names_refseq": "Clec2d5; Clec2d; Ocil", "protein_names_uniprotkb": "C-type lectin domain family 2 member D5; Osteoclast inhibitory lectin", "protein_names_refseq": "C-type lectin domain family 2 member D5; osteoclast inhibitory lectin", "tax_id": 10116, "disease": "", "pathway": " (rno:113937)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11278931;17462921;19127542", "class_list": "", "function": "Lectin-type cell surface receptor., [UniProtKB]; TranscriptionaL level gene expression regulation of rat OCIL gene, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046703 natural killer cell lectin-like receptor binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0050852 T cell receptor signaling pathway;GO:0042270 protection from natural killer cell mediated cytotoxicity;GO:0045671 negative regulation of osteoclast differentiation;GO:0051132 NK T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q925N7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JB3-1", "uniprot_id": [ { "id": "FUT9_RAT", "url": "https://www.uniprot.org/uniprot/Q99JB3", "type": "external" } ], "mass": 42037.0, "length": 359, "protein_name": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9", "gene_name": "Fut9", "organism": "Rat", "refseq_name": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9", "refseq_ac": [ { "id": "NP_445917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445917", "type": "external" } ], "gene_names_uniprotkb": "Fut9", "gene_names_refseq": "Fut9", "protein_names_uniprotkb": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9; 2.4.1.152; Fuc-TIX; FucT-IX; Fucosyltransferase 9; Fucosyltransferase IX; Galactoside 3-L-fucosyltransferase", "protein_names_refseq": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9; alpha-(1,3)-fucosyltransferase 9; fuc-TIX; fucT-IX; fucosyltransferase 9 (alpha (1,3) fucosyltransferase); fucosyltransferase IX; galactoside 3-L-fucosyltransferase", "tax_id": 10116, "disease": "candidiasis (Disease Ontology:DOID:1508)", "pathway": " (rno:84597); (R-RNO-9037629)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11020213;11675393;37674364", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc-) glycan attached to glycolipids and N- or O-linked glycoproteins. Fucosylates distal type 2 LacNAc and its fucosylated (H-type 2 LacNAc) and sialylated (sialyl-type 2 LacNAc) derivatives to form Lewis x (Lex) (CD15) and Lewis y (Ley) antigenic epitopes involved in cell adhesion and differentiation (By similarity) (PubMed:11020213, PubMed:11675393). Generates Lex epitopes in the brain, presumably playing a role in the maintenance of neuronal stemness and neurite outgrowth in progenitor neural cells (By similarity). Fucosylates the internal type 2 LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE (By similarity). Can also modify milk oligosaccharides in particular type 2 tetrasaccharide LNnT (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Fucosyltransferase 9 promotes neuronal differentiation and functional recovery after spinal cord injury by suppressing the activation of Notch signaling., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.152", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008417 fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0005802 trans-Golgi network;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0000271 polysaccharide biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 1336, "hit_score": 0.4, "record_id": "Q99JB3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MA0-1", "uniprot_id": [ { "id": "CITE4_RAT", "url": "https://www.uniprot.org/uniprot/Q99MA0", "type": "external" } ], "mass": 18158.0, "length": 179, "protein_name": "Cbp/p300-interacting transactivator 4", "gene_name": "Cited4", "organism": "Rat", "refseq_name": "cbp/p300-interacting transactivator 4", "refseq_ac": [ { "id": "NP_446151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446151", "type": "external" } ], "gene_names_uniprotkb": "Cited4; Mrg2", "gene_names_refseq": "Cited4; MRG-2; Mrg2", "protein_names_uniprotkb": "Cbp/p300-interacting transactivator 4; MRG-2; MSG1-related protein 2", "protein_names_refseq": "Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4; MSG1-related protein 2; cbp/p300-interacting transactivator 4", "tax_id": 10116, "disease": "", "pathway": " (rno:114491); (R-RNO-8866907)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19103603;24613264", "class_list": "", "function": "Acts as a transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells (By similarity)., [UniProtKB]; Cited4 expression follows a 24-hour pattern in the rat pineal gland in which night levels are 100-fold higher than day levels. This increase is driven by norepinephrine-cyclic AMP signaling., [RefSeq, PubMed]; Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0043627 response to estrogen", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q99MA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99NB2-1", "uniprot_id": [ { "id": "B3GN5_RAT", "url": "https://www.uniprot.org/uniprot/Q99NB2", "type": "external" } ], "mass": 44131.0, "length": 377, "protein_name": "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase", "gene_name": "B3gnt5", "organism": "Rat", "refseq_name": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase", "refseq_ac": [ { "id": "NP_446384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446384", "type": "external" } ], "gene_names_uniprotkb": "B3gnt5", "gene_names_refseq": "B3gnt5", "protein_names_uniprotkb": "Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; 2.4.1.206; BGnT-5; Beta-1,3-Gn-T5; Beta-1,3-N-acetylglucosaminyltransferase 5; Beta3Gn-T5; Lactotriaosylceramide synthase; Lc(3)Cer synthase; Lc3 synthase; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5", "protein_names_refseq": "BGnT-5; UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5; beta-1,3-Gn-T5; beta-1,3-N-acetylglucosaminyltransferase 5; beta3Gn-T5; lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; lactotriaosylceramide synthase; lc(3)Cer synthase; lc3 synthase", "tax_id": 10116, "disease": "", "pathway": " (rno:116740); (R-RNO-913709); (R-RNO-9840309)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "11283017", "class_list": "glycogene;glycosyltransferase", "function": "Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.206", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.206", "type": "external" } ], "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0047256 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0007417 central nervous system development", "synthesized_glycan_count": 545, "hit_score": 0.2, "record_id": "Q99NB2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PE7-1", "uniprot_id": [ { "id": "ABCG5_RAT", "url": "https://www.uniprot.org/uniprot/Q99PE7", "type": "external" } ], "mass": 73372.0, "length": 652, "protein_name": "ATP-binding cassette sub-family G member 5", "gene_name": "Abcg5", "organism": "Rat", "refseq_name": "ATP-binding cassette sub-family G member 5", "refseq_ac": [ { "id": "NP_446206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446206", "type": "external" } ], "gene_names_uniprotkb": "Abcg5", "gene_names_refseq": "Abcg5", "protein_names_uniprotkb": "ATP-binding cassette sub-family G member 5; 7.6.2.-; Sterolin-1", "protein_names_refseq": "ATP-binding cassette sub-family G (WHITE) member 5 (sterolin 1); ATP-binding cassette sub-family G member 5; ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1); ATP-binding cassette, subfamily G (WHITE), member 5; sterolin 1", "tax_id": 10116, "disease": "sitosterolemia 2 (Disease Ontology:DOID:0060983); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); sitosterolemia (Disease Ontology:DOID:0090019); cholestasis (Disease Ontology:DOID:13580); arteriosclerosis (Disease Ontology:DOID:2349); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:114628); (R-RNO-1369062)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11138003;12783625;21454685;25912874;28982675", "class_list": "", "function": "ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG8 has ATPase activity., [UniProtKB, UniProtKB]; Amino acid substitution in the sterol transport protein Abcg5 controls serum marinobufagenin levels in spontaneously hypertensive rats. Publication Status: Online-Only, [RefSeq, PubMed]; In contrast, the marked reduction of hepatic Abcg5/8 observed is an effect of the high sugar content of the diets., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIQ4", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex;GO:0045177 apical part of cell;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007584 response to nutrient;GO:0055085 transmembrane transport;GO:0031667 response to nutrient levels;GO:0010949 negative regulation of intestinal phytosterol absorption;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99PE7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PW7-1", "uniprot_id": [ { "id": "FSTL3_RAT", "url": "https://www.uniprot.org/uniprot/Q99PW7", "type": "external" } ], "mass": 27109.0, "length": 256, "protein_name": "Follistatin-related protein 3", "gene_name": "Fstl3", "organism": "Rat", "refseq_name": "follistatin-related protein 3 precursor", "refseq_ac": [ { "id": "NP_446081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446081", "type": "external" } ], "gene_names_uniprotkb": "Fstl3; Flrg", "gene_names_refseq": "Flrg; Fstl3", "protein_names_uniprotkb": "Follistatin-related protein 3; Follistatin-like protein 3; Follistatin-related gene protein", "protein_names_refseq": "follistatin-like 3 (secreted glycoprotein); follistatin-like protein 3; follistatin-related gene protein; follistatin-related protein 3 precursor; follistatin-related protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:114031); (R-RNO-2473224); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "12493714;21245136;22915069;25937185;34723652", "class_list": "", "function": "FSTL3 is a critical mediator of exercise-dependent bone formation, [RefSeq, PubMed]; Fstl3 as a stress-induced regulator of hypertrophy that controls myocyte size via regulation of Smad signaling., [RefSeq, PubMed]; Suggest FSTL3 has a role in paracrine communication between cardiomyocytes and fibroblasts., [RefSeq, PubMed]; The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients., [RefSeq, PubMed]; The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q54A93", "ec_number_list": [], "go_molecular_function": "GO:0048185 activin binding;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030141 secretory granule", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q99PW7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ER31-1", "uniprot_id": [ { "id": "ENTP6_RAT", "url": "https://www.uniprot.org/uniprot/Q9ER31", "type": "external" } ], "mass": 49899.0, "length": 455, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 6", "gene_name": "Entpd6", "organism": "Rat", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 6", "refseq_ac": [ { "id": "NP_445950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445950", "type": "external" } ], "gene_names_uniprotkb": "Entpd6; Cd39l2", "gene_names_refseq": "Entpd6", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 6; 3.6.1.6; CD39 antigen-like 2; NTPDase 6", "protein_names_refseq": "CD39 antigen-like 2; NTPDase 6; ectonucleoside triphosphate diphosphohydrolase 6", "tax_id": 10116, "disease": "", "pathway": " (rno:85260); (R-RNO-8850843)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11042118;23302703", "class_list": "", "function": "Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed:11042118). The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed:11042118)., [UniProtKB, PubMed]; NTPDase6 immunolocalisation in the vestibular end organ could be linked to the regulation of P2 receptor signalling and sensory transduction, including maintenance of vestibular hair bundles., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.64", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0004382 GDP phosphatase activity;GO:0045134 UDP phosphatase activity;GO:0008894 guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity;GO:0017110 nucleoside diphosphate phosphatase activity;GO:0017111 ribonucleoside triphosphate phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0051592 response to calcium ion;GO:0032026 response to magnesium ion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ER31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERZ8-1", "uniprot_id": [ { "id": "TRPV4_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERZ8", "type": "external" } ], "mass": 98010.0, "length": 871, "protein_name": "Transient receptor potential cation channel subfamily V member 4", "gene_name": "Trpv4", "organism": "Rat", "refseq_name": "transient receptor potential cation channel subfamily V member 4", "refseq_ac": [ { "id": "NP_076460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076460", "type": "external" } ], "gene_names_uniprotkb": "Trpv4; Vroac", "gene_names_refseq": "Otrpc4; Trpv4; Vroac", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily V member 4; OTRPC4; Osm-9-like TRP channel 4; TrpV4; VR-OAC; Vanilloid receptor-related osmotically-activated channel", "protein_names_refseq": "VR-OAC; osm-9-like TRP channel 4; osmosensitive transient receptor potential channel 4; transient receptor potential cation channel subf V memb 4; transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily 5, member 4; vanilloid receptor-related osmotically activated channel (Vroac); vanilloid receptor-related osmotically-activated channel", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease axonal type 2C (Disease Ontology:DOID:0110182); autosomal dominant nonsyndromic deafness 25 (Disease Ontology:DOID:0110555); autosomal dominant distal hereditary motor neuronopathy 8 (Disease Ontology:DOID:0111215); metatropic dysplasia (Disease Ontology:DOID:0111514); parastremmatic dwarfism (Disease Ontology:DOID:0111539); scapuloperoneal spinal muscular atrophy (Disease Ontology:DOID:0111552); spondyloepiphyseal dysplasia Maroteaux type (Disease Ontology:DOID:0111553); spondylometaphyseal dysplasia Kozlowski type (Disease Ontology:DOID:0111554); osteonecrosis (Disease Ontology:DOID:10159); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:66026); (R-RNO-3295583); (R-RNO-9856530)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11081638;16627472;29438227;37966569;37981067;38226418;38735619", "class_list": "", "function": "AQP4 regulates ferroptosis and oxidative stress of Muller cells in diabetic retinopathy by regulating TRPV4., [RefSeq, PubMed]; Evaluation of GSK2789917-induced TRPV4 inhibition in animal models of fluid induced lung injury., [RefSeq, PubMed]; Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension., [RefSeq, PubMed]; Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11081638). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:11081638). Also activated by heat, low pH, citrate and phorbol esters (By similarity). Increase of intracellular Ca(2+) potentiates currents (By similarity). Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (By similarity). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Together with PKD2, forms mechano- and thermosensitive channels in cilium (By similarity). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to pro-inflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (By similarity). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (By similarity). In neurons of the central nervous system, could play a role in triggering voluntary water intake in response to increased sodium concentration in body fluid (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; TRPV4 blockade alleviates endoplasmic reticulum stress mediated apoptosis in hypoxia-induced cardiomyocyte injury., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0005929 cilium", "go_biological_process": "GO:0071476 cellular hypotonic response;GO:0046785 microtubule polymerization;GO:0031117 positive regulation of microtubule depolymerization;GO:0007231 osmosensory signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9ERZ8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESG3-1", "uniprot_id": [ { "id": "CLTRN_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESG3", "type": "external" } ], "mass": 25051.0, "length": 222, "protein_name": "Collectrin", "gene_name": "Cltrn", "organism": "Rat", "refseq_name": "collectrin precursor", "refseq_ac": [ { "id": "NP_066125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066125", "type": "external" } ], "gene_names_uniprotkb": "Cltrn; Nx17; Tmem27", "gene_names_refseq": "Cltrn; NX-17; Nx17; Tmem27; collectrin", "protein_names_uniprotkb": "Collectrin; Transmembrane protein 27", "protein_names_refseq": "collectrin precursor; kidney-specific membrane protein; transmembrane protein 27", "tax_id": 10116, "disease": "", "pathway": " (rno:57395)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11278314;16330323;18981302;22701690", "class_list": "", "function": "Collectrin expression in the retinal pigment epithelium was significantly modulated during aging., [RefSeq, PubMed]; Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (By similarity)., [UniProtKB, UniProtKB, PubMed]; Upregulation of collectrin by high NaCl independent of aldosterone functionally links to the trafficking of apical membrane proteins via the SNARE complex, and collectrin may be responsible for the sodium retention in salt-sensitive hypertension. Erratum:[Circulation. 2014 Feb 4;129(5):e325], [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6AYY2", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0141109 transporter activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0017156 calcium-ion regulated exocytosis;GO:0035493 SNARE complex assembly;GO:0035773 insulin secretion involved in cellular response to glucose stimulus;GO:0051957 positive regulation of amino acid transport;GO:0089718 amino acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9ESG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI15-1", "uniprot_id": [ { "id": "CK2N1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JI15", "type": "external" } ], "mass": 8513.0, "length": 78, "protein_name": "Calcium/calmodulin-dependent protein kinase II inhibitor 1", "gene_name": "Camk2n1", "organism": "Rat", "refseq_name": "calcium/calmodulin-dependent protein kinase II inhibitor 1", "refseq_ac": [ { "id": "NP_775459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775459", "type": "external" } ], "gene_names_uniprotkb": "Camk2n1", "gene_names_refseq": "Camk2n1", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase II inhibitor 1; CaM-KIINalpha; CaMKIINalpha; calcium/calmodulin-dependent protein kinase II inhibitor alpha", "protein_names_refseq": "CaM-kinase II inhibitor alpha; caM-KIINalpha; caMKIINalpha; calcium/calmodulin-dependent protein kinase II inhibitor 1; calcium/calmodulin-dependent protein kinase II inhibitor alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:287005)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11182241;31327268;32320502", "class_list": "", "function": "CaMKII inhibitor 1 (CaMK2N1) mRNA is upregulated following LTP induction in hippocampal slices., [RefSeq, PubMed]; Potent and specific inhibitor of CaM-kinase II (CAMK2) (PubMed:11182241). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (PubMed:31327268). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (PubMed:31327268)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0008427 calcium-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0045202 synapse", "go_biological_process": "GO:0003084 positive regulation of systemic arterial blood pressure;GO:0007268 chemical synaptic transmission;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0050729 positive regulation of inflammatory response;GO:0007616 long-term memory", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JI15-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIY6-1", "uniprot_id": [ { "id": "NAT8B_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIY6", "type": "external" } ], "mass": 24809.0, "length": 222, "protein_name": "N-acetyltransferase 8B", "gene_name": "Nat8b", "organism": "Rat", "refseq_name": "N-acetyltransferase 8B", "refseq_ac": [ { "id": "NP_598242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598242", "type": "external" } ], "gene_names_uniprotkb": "Nat8b; Cml1; Cml6", "gene_names_refseq": "Cml1; Cml6; Nat8b; Nat8; RGD621605", "protein_names_uniprotkb": "N-acetyltransferase 8B; 2.3.1.-; Camello-like protein 1; Camello-like protein 6; Protein-lysine N6-acetyltransferase 8B", "protein_names_refseq": "N-acetyltransferase 8B; camello-like 1 like; camello-like protein 1; camello-like protein 6; probable N-acetyltransferase 8B; probable N-acetyltransferase CML6; protein-lysine N6-acetyltransferase 8B", "tax_id": 10116, "disease": "", "pathway": " (rno:171084)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11397015", "class_list": "", "function": "Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. Acetylates and stabilizes BACE1 immature protein, leading to increased steady-state levels in neurons. By acting on BACE1 expression, may regulate amyloid beta-peptide formation (By similarity). N(6)-lysine acetylation in ER maintains protein homeostasis and regulates reticulophagy (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.80", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0050435 amyloid-beta metabolic process;GO:0006084 acetyl-CoA metabolic process;GO:0016241 regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JIY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJ46-1", "uniprot_id": [ { "id": "EBP_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJ46", "type": "external" } ], "mass": 26738.0, "length": 230, "protein_name": "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase", "gene_name": "Ebp", "organism": "Rat", "refseq_name": "3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase", "refseq_ac": [ { "id": "NP_476478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476478", "type": "external" } ], "gene_names_uniprotkb": "Ebp; Rsi", "gene_names_refseq": "Ebp", "protein_names_uniprotkb": "3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; 3.3.2.11; 5.3.3.5; Cholestenol Delta-isomerase; Cholesterol-5,6-epoxide hydrolase subunit EBP; D8-D7 sterol isomerase; Delta(8)-Delta(7) sterol isomerase; Emopamil-binding protein; Sterol 8-isomerase", "protein_names_refseq": "3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase; D8-D7 sterol isomerase; cholestenol Delta-isomerase; cholesterol-5,6-epoxide hydrolase subunit EBP; delta(8)-Delta(7) sterol isomerase; emopamil binding protein (sterol isomerase); emopamil-binding protein; phenylalkylamine Ca2+ antagonist (emopamil) binding protein; sterol 8-isomerase", "tax_id": 10116, "disease": "X-linked chondrodysplasia punctata 1 (Disease Ontology:DOID:0060292); X-linked chondrodysplasia punctata 2 (Disease Ontology:DOID:0080352); MEND syndrome (Disease Ontology:DOID:0111865); chondrodysplasia punctata (Disease Ontology:DOID:2581)", "pathway": " (rno:117278); (R-RNO-6807047); (R-RNO-9969901)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "11171067", "class_list": "", "function": "Component of the microsomal antiestrogen binding site (AEBS), a multiproteic complex at the ER membrane that consists of an association between EBP and 7-dehydrocholesterol reductase/DHCR7. This complex is responsible for cholesterol-5,6-epoxide hydrolase (ChEH) activity, which consists in the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3beta,5alpha,6beta-triol (CT). The precise role of each component of this complex has not been described yet., [UniProtKB, UniProtKB]; Isomerase that catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q548M8", "ec_number_list": [ { "id": "5.3.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.5", "type": "external" }, { "id": "3.3.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.11", "type": "external" }, { "id": "1.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.21", "type": "external" }, { "id": "1.3.1.70", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004769 steroid Delta-isomerase activity;GO:0047750 cholestenol delta-isomerase activity;GO:0000247 C-8 sterol isomerase activity;GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0008203 cholesterol metabolic process;GO:0016126 sterol biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JJ46-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJH5-1", "uniprot_id": [ { "id": "F262_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJH5", "type": "external" } ], "mass": 64156.0, "length": 557, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2", "gene_name": "Pfkfb2", "organism": "Rat", "refseq_name": "6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform b", "refseq_ac": [ { "id": "NP_001029136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029136", "type": "external" } ], "gene_names_uniprotkb": "Pfkfb2", "gene_names_refseq": "PFK-2; Pfkfb2; RH2K", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; PFK/FBPase 2; RH2K", "protein_names_refseq": "6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (heart); 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform b; 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme; 6PF-2-K/Fru-2,6-P2ase 2; PFK-2/FBPase-2; PFK/FBPase 2; fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase", "tax_id": 10116, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); mucositis (Disease Ontology:DOID:0080178); COVID-19 (Disease Ontology:DOID:0080600); severe congenital neutropenia 1 (Disease Ontology:DOID:0080625); pleurisy (Disease Ontology:DOID:10247); disseminated intravascular coagulation (Disease Ontology:DOID:11247); toxic shock syndrome (Disease Ontology:DOID:14115); essential thrombocythemia (Disease Ontology:DOID:2224); transient cerebral ischemia (Disease Ontology:DOID:224); suppurative periapical periodontitis (Disease Ontology:DOID:2562); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); cyclic hematopoiesis (Disease Ontology:DOID:5339); periodontitis (Disease Ontology:DOID:824); polycythemia vera (Disease Ontology:DOID:8997); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:24640); (R-RNO-9634600)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "18039179;18199594;22673903;23457334;29393594;8292038", "class_list": "", "function": "Amino acids stimulate Fru-2,6-P2 synthesis by Akt-dependent PFKFB2 phosphorylation and activation and show how signaling and metabolism are inextricably linked., [RefSeq, PubMed]; Mechanisms downstream of AMP-activated protein kinase activation, involving phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and GKRP are involved in the ATP-independent inhibition of glucose-induced glucokinase translocation, [RefSeq, PubMed]; Rat islets expressed PFKFB2 lacking the C-terminal phosphorylation sites. PFK-2/FBPase-2 protein rather than its product fructose 2,6-P(2) is the over-riding determinant of glucose-induced insulin secretion through regulation of glucokinase activity, [RefSeq, PubMed]; Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64297;Q9JHL5;Q9JJH4", "ec_number_list": [ { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" }, { "id": "2.7.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.105", "type": "external" } ], "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019900 kinase binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006000 fructose metabolic process;GO:0006096 glycolytic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JJH5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK41-1", "uniprot_id": [ { "id": "COPT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JK41", "type": "external" } ], "mass": 21129.0, "length": 187, "protein_name": "High affinity copper uptake protein 1", "gene_name": "Slc31a1", "organism": "Rat", "refseq_name": "high affinity copper uptake protein 1", "refseq_ac": [ { "id": "NP_598284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598284", "type": "external" } ], "gene_names_uniprotkb": "Slc31a1; Copt1; Ctr1", "gene_names_refseq": "Ctr1; LRRGT00200; Slc31a1", "protein_names_uniprotkb": "High affinity copper uptake protein 1; Copper transporter 1; Liver regeneration-related protein LRRGT00200; Solute carrier family 31 member 1; rCTR1", "protein_names_refseq": "Copper uptake transporter 1; copper transporter 1; high affinity copper uptake protein 1; liver regeneration-related protein LRRGT00200; rCTR1; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporters), member 1", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (rno:171135); (R-RNO-425410)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16637264;20699218;23123662;24316150", "class_list": "", "function": "CTR1 and ATP7A play important roles in Cu transport in choroidal epithelial cells, and the Pb-induced intracellular Cu accumulation appears to be mediated, at least in part, via the alteration of CTR1 and ATP7A expression levels following Pb exposure., [RefSeq, PubMed]; Data suggest that Ctr1 is responsible for transport (and accumulation) of copper salts (CuCl2; CuSO4) and organoplatinum compounds in dorsal root ganglion neurons; Ctr1 is thus involved in neurotoxicity of such antineoplastic drugs., [RefSeq, PubMed]; It has been shown that SLC31A1 gene activity correlates with the rate of both intracellular and extracellular copper-containing enzymes formation., [RefSeq, PubMed]; Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane (PubMed:23123662). Then, delivers directly copper(1+) to specific chaperone such as ATOX1, via a copper(1+)- mediated transient interaction between the C-terminal domain and a copper(1+) chaperone, thus controlling intracellular copper(1+) levels (By similarity). May function in copper(1+) import from the apical membrane thus may drive intestinal copper absorption (By similarity). The copper(1+) transport mechanism is sodium-independent, saturable and of high-affinity (PubMed:23123662). Also mediates the uptake of silver(1+) (By similarity). May function in the influx of the platinum-containing chemotherapeutic agents (PubMed:23123662). The platinum-containing chemotherapeutic agents uptake is saturable (PubMed:23123662). Also participates in the first step of copper(2+) acquisition by cells through a direct transfer of copper(2+) from copper(2+) carriers in blood, such as ALB to the N-terminal domain of SLC31A1, leading to copper(2+) reduction and probably followed by copper(1+) stabilization (By similarity). In addition, functions as a redox sensor to promote angiogenesis in endothelial cells, in a copper(1+) transport independent manner, by transmitting the VEGF-induced ROS signal through a sulfenylation at Cys-189 leading to a subsequent disulfide bond formation between SLC31A1 and KDR (By similarity). The SLC31A1-KDR complex is then co-internalized to early endosomes, driving a sustained VEGFR2 signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q53YN6", "ec_number_list": [], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0042802 identical protein binding;GO:0005507 copper ion binding;GO:0005375 copper ion transmembrane transporter activity;GO:0015080 silver ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0043025 neuronal cell body;GO:0055037 recycling endosome;GO:0014704 intercalated disc", "go_biological_process": "GO:0035434 copper ion transmembrane transport;GO:0001525 angiogenesis;GO:0006878 intracellular copper ion homeostasis;GO:0051259 protein complex oligomerization;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9JK41-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLG9-1", "uniprot_id": [ { "id": "AIPL1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLG9", "type": "external" } ], "mass": 38294.0, "length": 328, "protein_name": "Aryl-hydrocarbon-interacting protein-like 1", "gene_name": "Aipl1", "organism": "Rat", "refseq_name": "aryl-hydrocarbon-interacting protein-like 1", "refseq_ac": [ { "id": "NP_067601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067601", "type": "external" } ], "gene_names_uniprotkb": "Aipl1", "gene_names_refseq": "Aipl1", "protein_names_uniprotkb": "Aryl-hydrocarbon-interacting protein-like 1", "protein_names_refseq": "aryl hydrocarbon receptor-interacting protein-like 1; aryl-hydrocarbon-interacting protein-like 1", "tax_id": 10116, "disease": "Leber congenital amaurosis 4 (Disease Ontology:DOID:0110332); retinitis pigmentosa (Disease Ontology:DOID:10584); blindness (Disease Ontology:DOID:1432); Leber congenital amaurosis (Disease Ontology:DOID:14791)", "pathway": " (rno:59110)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10615133", "class_list": "", "function": "May be important in protein trafficking and/or protein folding and stabilization., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001918 farnesylated protein binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007603 phototransduction, visible light;GO:0001895 retina homeostasis;GO:0018343 protein farnesylation;GO:0022400 regulation of opsin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JLG9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLH6-1", "uniprot_id": [ { "id": "CK5P1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLH6", "type": "external" } ], "mass": 65866.0, "length": 586, "protein_name": "Mitochondrial tRNA methylthiotransferase CDK5RAP1", "gene_name": "Cdk5rap1", "organism": "Rat", "refseq_name": "mitochondrial tRNA methylthiotransferase CDK5RAP1", "refseq_ac": [ { "id": "NP_663773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663773", "type": "external" } ], "gene_names_uniprotkb": "Cdk5rap1", "gene_names_refseq": "Cdk5rap1", "protein_names_uniprotkb": "Mitochondrial tRNA methylthiotransferase CDK5RAP1; 2.8.4.3; CDK5 activator-binding protein C42; CDK5 regulatory subunit-associated protein 1; mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase; mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase", "protein_names_refseq": "CDK5 activator-binding protein C42; CDK5 regulatory subunit associated protein 1; mitochondrial tRNA methylthiotransferase CDK5RAP1; mt-tRNA-2-methylthio-N6-dimethylallyladenosine synthase; mt-tRNA-N6-(dimethylallyl)adenosine(37) methylthiotransferase", "tax_id": 10116, "disease": "", "pathway": " (rno:252827)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10721722", "class_list": "", "function": "Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (By similarity). Essential for efficient and highly accurate protein translation by the ribosome (By similarity). Specifically inhibits CDK5 activation by CDK5R1 (By similarity). Essential for efficient mitochondrial protein synthesis and respiratory chain (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.4.3", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0044877 protein-containing complex binding;GO:0035597 tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity;GO:0035596 methylthiotransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0009451 RNA modification;GO:0070131 positive regulation of mitochondrial translation;GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JLH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXQ6-1", "uniprot_id": [ { "id": "GALP_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXQ6", "type": "external" } ], "mass": 12600.0, "length": 115, "protein_name": "Galanin-like peptide", "gene_name": "Galp", "organism": "Rat", "refseq_name": "galanin-like peptide precursor", "refseq_ac": [ { "id": "NP_072155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072155", "type": "external" } ], "gene_names_uniprotkb": "Galp", "gene_names_refseq": "Galp", "protein_names_uniprotkb": "Galanin-like peptide", "protein_names_refseq": "galanin-like peptide precursor", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:64568)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10601261;12586757;12672543;12746327;12933672;17950941;19124073;22681480", "class_list": "", "function": "Cell activation induced by GALP in the supraoptic hypothalamic nucleus and nucleus tractus solitarius was dependent on food intake but independent of food consumption in all other brain regions., [RefSeq, PubMed]; Hypothalamic GALP gene expression is controlled by leptin signals and suggests possible involvement of GALP in the reproductive abnormalities of the Zucker obese rat., [RefSeq, PubMed]; Hypothalamic galanin-like peptide rescues the onset of puberty in food-restricted weanling rats., [RefSeq, PubMed]; Hypothalamic neuropeptide which binds to the G protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion (By similarity)., [UniProtKB]; Present observations are consistent with the argument that galanin-like peptide (GALP) is a downstream effector of leptin's actions within the central nervous system, [RefSeq, PubMed]; Regulatory mechanism of GALP mRNA is different from that of the neuropeptide Y and proopiomelanocortin genes during postnatal development, [RefSeq, PubMed]; These data suggest that GALP activates feeding and sexual behaviors in male rats by stimulating dopaminergic neurons that terminate within the mPOA., [RefSeq, PubMed]; This is the first study to demonstrate close apposition of galanin-like peptide (GALP)-immunoreactive cell bodies and GALP neurons expressing OX1-receptors in direct contact with orexin (OX1)-immunoreactive terminals in the arcuate nucleus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0042595 behavioral response to starvation;GO:0007218 neuropeptide signaling pathway;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0032098 regulation of appetite;GO:0032868 response to insulin", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9QXQ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXT4-1", "uniprot_id": [ { "id": "CMLO1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXT4", "type": "external" } ], "mass": 24857.0, "length": 221, "protein_name": "N-acetyltransferase 8F1", "gene_name": "Nat8f1", "organism": "Rat", "refseq_name": "N-acetyltransferase 8F1", "refseq_ac": [ { "id": "NP_067700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067700", "type": "external" } ], "gene_names_uniprotkb": "Nat8f1; Cml1; Cml2", "gene_names_refseq": "Cml2; Nat8f1", "protein_names_uniprotkb": "N-acetyltransferase 8F1; 2.3.1.-; Camello-like protein 1; Camello-like protein 2; GCN5-related N-acetyltransferase 8, family member 1", "protein_names_refseq": "GCN5-related N-acetyltransferase 8, family member 1; N-acetyltransferase 8F1; camello-like 1; camello-like protein 1; camello-like protein 2; probable N-acetyltransferase CML1-like; probable N-acetyltransferase CML1; putative N-acetyltransferase Camello 2", "tax_id": 10116, "disease": "", "pathway": " (rno:59300)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11397015;22267734", "class_list": "", "function": "Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces beta-secretase (BACE1) levels and Abeta generation., [RefSeq, PubMed]; May play a role in regulation of gastrulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001702 gastrulation with mouth forming second", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QXT4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYC5-1", "uniprot_id": [ { "id": "G37L1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYC5", "type": "external" } ], "mass": 52860.0, "length": 481, "protein_name": "G protein-coupled receptor 37-like 1", "gene_name": "Gpr37l1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Gpr37l1; Etbrlp2", "gene_names_refseq": "", "protein_names_uniprotkb": "G protein-coupled receptor 37-like 1; ETBR-LP-2; Endothelin B receptor-like protein 2; G protein-coupled receptor CNS2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-375276); (R-RNO-418594)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10350639;22673903;27072655", "class_list": "", "function": "G protein-coupled receptor (By similarity). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036505 prosaposin receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity;GO:0042277 peptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0060170 ciliary membrane", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0045665 negative regulation of neuron differentiation;GO:0003085 negative regulation of systemic arterial blood pressure;GO:0034614 cellular response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QYC5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYJ4-1", "uniprot_id": [ { "id": "ABCB9_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYJ4", "type": "external" } ], "mass": 84033.0, "length": 762, "protein_name": "ABC-type oligopeptide transporter ABCB9", "gene_name": "Abcb9", "organism": "Rat", "refseq_name": "ABC-type oligopeptide transporter ABCB9", "refseq_ac": [ { "id": "NP_071574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071574", "type": "external" } ], "gene_names_uniprotkb": "Abcb9", "gene_names_refseq": "Abcb9; Tapl", "protein_names_uniprotkb": "ABC-type oligopeptide transporter ABCB9; 7.4.2.6; ABC transporter 9 protein; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; TAP-like protein; TAPL", "protein_names_refseq": "ABC transporter 9 protein; ABC-type oligopeptide transporter ABCB9; ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ATP-binding cassette, sub-family B (MDR/TAP), member 9; ATP-binding cassette, subfamily B (MDR/TAP), member 9; TAP-like ABC transporter; TAP-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:63886); (R-RNO-382556)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10471785;14709908;18175933", "class_list": "", "function": "ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q764Q5;Q764Q6", "ec_number_list": [ { "id": "7.4.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:7.4.2.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0043190 ATP-binding cassette (ABC) transporter complex", "go_biological_process": "GO:0015031 protein transport;GO:0055085 transmembrane transport;GO:0006518 peptide metabolic process;GO:0015833 peptide transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QYJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYW5-1", "uniprot_id": [ { "id": "EMP3_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYW5", "type": "external" } ], "mass": 18198.0, "length": 163, "protein_name": "Epithelial membrane protein 3", "gene_name": "Emp3", "organism": "Rat", "refseq_name": "epithelial membrane protein 3", "refseq_ac": [ { "id": "NP_110474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110474", "type": "external" } ], "gene_names_uniprotkb": "Emp3", "gene_names_refseq": "Emp3", "protein_names_uniprotkb": "Epithelial membrane protein 3; EMP-3", "protein_names_refseq": "EMP-3; epithelial membrane protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:81505)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10570147", "class_list": "", "function": "Probably involved in cell proliferation and cell-cell interactions., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0032060 bleb assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QYW5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZH0-1", "uniprot_id": [ { "id": "FZD4_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZH0", "type": "external" } ], "mass": 60355.0, "length": 538, "protein_name": "Frizzled-4", "gene_name": "Fzd4", "organism": "Rat", "refseq_name": "frizzled-4 precursor", "refseq_ac": [ { "id": "NP_072145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072145", "type": "external" } ], "gene_names_uniprotkb": "Fzd4", "gene_names_refseq": "Fzd4", "protein_names_uniprotkb": "Frizzled-4; Fz-4; rFz4", "protein_names_refseq": "frizzled family receptor 4; frizzled receptor 4; frizzled-4 precursor; frizzled-4; fz-4; rFz4", "tax_id": 10116, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); Norrie disease (Disease Ontology:DOID:0060844); exudative vitreoretinopathy 1 (Disease Ontology:DOID:0111412); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:64558); (R-RNO-4086398); (R-RNO-4608870); (R-RNO-4641263); (R-RNO-5099900); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "12072409;25424568;25550365;34119828", "class_list": "", "function": "Activation of frizzled-4 receptor protected blood-brain barrier after subarachnoid hemorrhage., [RefSeq, PubMed]; Detected expression of a putative wnt receptor, frizzled-4 (fzd-4) in the ovary; analyses using both RT-PCR and ISH indicated that granulosa cells express fzd-4 mRNA, [RefSeq, PubMed]; MiR-129-5p in exosomes inhibits diabetes-associated osteogenesis in the jaw via targeting FZD4., [RefSeq, PubMed]; Receptor for Wnt proteins (By similarity). Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (By similarity). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase (By similarity). Both pathways seem to involve interactions with G proteins (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Study identified a novel Wnt5a/Fzd4 signaling pathway that contributes to the regulation of dendrite morphogenesis, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0001540 amyloid-beta binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0030425 dendrite", "go_biological_process": "GO:0060856 establishment of blood-brain barrier;GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0008283 cell population proliferation;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QZH0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZH7-1", "uniprot_id": [ { "id": "FXL20_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZH7", "type": "external" } ], "mass": 30460.0, "length": 276, "protein_name": "F-box/LRR-repeat protein 20", "gene_name": "Fbxl20", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fbxl20; Fbl2", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box/LRR-repeat protein 20; F-box and leucine-rich repeat protein 20; F-box/LRR-repeat protein 2-like", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10508920", "class_list": "", "function": "Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0019005 SCF ubiquitin ligase complex;GO:0098793 presynapse", "go_biological_process": "GO:0001662 behavioral fear response;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099575 regulation of protein catabolic process at presynapse, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QZH7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0T3-1", "uniprot_id": [ { "id": "DNJC3_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0T3", "type": "external" } ], "mass": 57561.0, "length": 504, "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "Dnajc3", "organism": "Rat", "refseq_name": "dnaJ homolog subfamily C member 3 precursor", "refseq_ac": [ { "id": "NP_071568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071568", "type": "external" } ], "gene_names_uniprotkb": "Dnajc3; P58ipk", "gene_names_refseq": "Dnajc3", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 3; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 3; dnaJ homolog subfamily C member 3 precursor; dnaJ homolog subfamily C member 3; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58", "tax_id": 10116, "disease": "", "pathway": " (rno:63880); (R-RNO-381426); (R-RNO-6798695); (R-RNO-8957275); (R-RNO-9833482)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "22673903;23395000", "class_list": "", "function": "Endoplasmic reticulum stress activation and p58(IPK) expression control the fate of malignant cells facing glucose shortage., [RefSeq, PubMed]; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7A0", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0051087 protein-folding chaperone binding;GO:0004860 protein kinase inhibitor activity;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005790 smooth endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0036494 positive regulation of translation initiation in response to endoplasmic reticulum stress;GO:0070417 cellular response to cold;GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R0T3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0Z7-1", "uniprot_id": [ { "id": "AAGAB_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0Z7", "type": "external" } ], "mass": 34363.0, "length": 315, "protein_name": "Alpha- and gamma-adaptin-binding protein p34", "gene_name": "Aagab", "organism": "Rat", "refseq_name": "alpha- and gamma-adaptin-binding protein p34", "refseq_ac": [ { "id": "NP_599225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599225", "type": "external" } ], "gene_names_uniprotkb": "Aagab; P34", "gene_names_refseq": "Aagab; P34", "protein_names_uniprotkb": "Alpha- and gamma-adaptin-binding protein p34", "protein_names_refseq": "alpha- and gamma-adaptin-binding protein p34", "tax_id": 10116, "disease": "punctate palmoplantar keratoderma type I (Disease Ontology:DOID:0080214)", "pathway": " (rno:171435)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10477754;22673903", "class_list": "", "function": "May be involved in endocytic recycling of growth factor receptors such as EGFR., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R0Z7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTQ7-1", "uniprot_id": [ { "id": "GA45G_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTQ7", "type": "external" } ], "mass": 17287.0, "length": 159, "protein_name": "Growth arrest and DNA damage-inducible protein GADD45 gamma", "gene_name": "Gadd45g", "organism": "Rat", "refseq_name": "growth arrest and DNA damage-inducible protein GADD45 gamma", "refseq_ac": [ { "id": "NP_001071108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071108", "type": "external" } ], "gene_names_uniprotkb": "Gadd45g", "gene_names_refseq": "Gadd45g", "protein_names_uniprotkb": "Growth arrest and DNA damage-inducible protein GADD45 gamma", "protein_names_refseq": "GADD45gamma; growth arrest and DNA damage inducible; growth arrest and DNA damage-inducible protein GADD45 gamma; growth arrest and DNA-damage-inducible 45 gamma", "tax_id": 10116, "disease": "mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783)", "pathway": " (rno:291005)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10100865;19882653;27086974;32828305", "class_list": "", "function": "Gadd45 gamma gene expression is involved in regulating glomerular mesangial cell apoptosis mediated by sublytic C5b-9 in Thy-1 nephritis, [RefSeq, PubMed]; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK., [UniProtKB]; MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling., [RefSeq, PubMed]; Report of sex differences in the expression of growth arrest and DNA damage inducible factor beta (Gadd45b), but not family members alpha (a) or gamma (g), in the neonatal and juvenile rodent amygdala, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0043065 positive regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0046330 positive regulation of JNK cascade;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WTQ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WU06-1", "uniprot_id": [ { "id": "AVIL_RAT", "url": "https://www.uniprot.org/uniprot/Q9WU06", "type": "external" } ], "mass": 91894.0, "length": 819, "protein_name": "Advillin", "gene_name": "Avil", "organism": "Rat", "refseq_name": "advillin", "refseq_ac": [ { "id": "NP_077377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077377", "type": "external" } ], "gene_names_uniprotkb": "Avil; Advil; Pervin", "gene_names_refseq": "Avil", "protein_names_uniprotkb": "Advillin; Peripheral nervous system villin-like protein; Pervin", "protein_names_refseq": "advillin; peripheral nervous system villin-like protein; pervin", "tax_id": 10116, "disease": "nephrotic syndrome type 21 (Disease Ontology:DOID:0112267)", "pathway": " (rno:79253)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11849295;29058690", "class_list": "", "function": "Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates (PubMed:11849295). Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M0RCA6", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005884 actin filament;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0007015 actin filament organization;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WU06-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z286-1", "uniprot_id": [ { "id": "ADCYA_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z286", "type": "external" } ], "mass": 185854.0, "length": 1608, "protein_name": "Adenylate cyclase type 10", "gene_name": "Adcy10", "organism": "Rat", "refseq_name": "adenylate cyclase type 10", "refseq_ac": [ { "id": "NP_067716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067716", "type": "external" } ], "gene_names_uniprotkb": "Adcy10; Sac", "gene_names_refseq": "Adcy10; Sac", "protein_names_uniprotkb": "Adenylate cyclase type 10; 4.6.1.1; Germ cell soluble adenylyl cyclase; Testicular soluble adenylyl cyclase; sAC", "protein_names_refseq": "adenylate cyclase 10 (soluble); adenylate cyclase type 10; germ cell soluble adenylyl cyclase; testicular soluble adenylyl cyclase", "tax_id": 10116, "disease": "", "pathway": " (rno:59320); (R-RNO-5610787)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11423534;12475901;12609998;14512417;31172217;9874775", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP (PubMed:9874775). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; Description of a novel pathway for pH regulation linking the bicarbonate activated soluble adenylyl cyclase to the vacuolar H+ATPase, [RefSeq, PubMed]; The sAC( type 10 soluble adenylyl cyclase)-EPAC axis may regulate basal and induced AMPK activity and support mitophagy, cellular energy and redox homeostasis. The study argues for sAC as a potential target in treating pathologies associated with AMPK downregulation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0045819 positive regulation of glycogen catabolic process;GO:2001171 positive regulation of ATP biosynthetic process;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0006171 cAMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z286-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2N6-1", "uniprot_id": [ { "id": "CK2N2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2N6", "type": "external" } ], "mass": 8628.0, "length": 79, "protein_name": "Calcium/calmodulin-dependent protein kinase II inhibitor 2", "gene_name": "Camk2n2", "organism": "Rat", "refseq_name": "calcium/calmodulin-dependent protein kinase II inhibitor 2", "refseq_ac": [ { "id": "NP_067710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067710", "type": "external" } ], "gene_names_uniprotkb": "Camk2n2", "gene_names_refseq": "Camk2n2", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase II inhibitor 2; CaM-KII inhibitory protein; CaM-KIINbeta; CaM-KIIN", "protein_names_refseq": "CaM-KII inhibitory protein; caM-KIINbeta; caM-KIIN; calcium/calmodulin-dependent protein kinase II inhibitor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:59314)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11182241;17942605;24520120;9724800", "class_list": "", "function": "High-fat diet-induced mitochondrial biogenesis is regulated by mitochondrial-derived reactive oxygen species activation of CaMKII, [RefSeq, PubMed]; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2) (PubMed:17942605, PubMed:9724800). Traps Ca(2+)/calmodulin on CAMK2 (PubMed:17942605)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0008427 calcium-dependent protein kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z2N6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0G2JXN2-1", "uniprot_id": [ { "id": "TRI46_RAT", "url": "https://www.uniprot.org/uniprot/A0A0G2JXN2", "type": "external" } ], "mass": 83431.0, "length": 759, "protein_name": "Tripartite motif-containing protein 46", "gene_name": "Trim46", "organism": "Rat", "refseq_name": "tripartite motif-containing protein 46", "refseq_ac": [ { "id": "NP_001382034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382034", "type": "external" } ], "gene_names_uniprotkb": "Trim46", "gene_names_refseq": "Trim46", "protein_names_uniprotkb": "Tripartite motif-containing protein 46", "protein_names_refseq": "tripartite motif protein 46; tripartite motif-containing protein 46-like; tripartite motif-containing protein 46", "tax_id": 10116, "disease": "", "pathway": " (rno:310641)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22673903;26671463;30967428;38843836", "class_list": "", "function": "In the present study we developed a novel correlative light and electron microscopy approach to study the axon initial segment microtubules during neuron development and identified an essential role for TRIM46 in microtubule fasciculation, [RefSeq, PubMed]; Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A096MKD9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0044304 main axon;GO:1904115 axon cytoplasm;GO:0043194 axon initial segment;GO:1990769 proximal neuron projection", "go_biological_process": "GO:0099612 protein localization to axon;GO:0007409 axonogenesis;GO:0001764 neuron migration;GO:0032880 regulation of protein localization;GO:0048490 anterograde synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A0G2JXN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNC9-1", "uniprot_id": [ { "id": "QORL2_RAT", "url": "https://www.uniprot.org/uniprot/B0BNC9", "type": "external" } ], "mass": 37548.0, "length": 350, "protein_name": "Protein Cryzl2", "gene_name": "Cryzl2", "organism": "Rat", "refseq_name": "protein Cryzl2", "refseq_ac": [ { "id": "NP_001388369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388369", "type": "external" } ], "gene_names_uniprotkb": "Cryzl2; Tp53i3", "gene_names_refseq": "Cryzl2; RGD1304982; Tp53i3", "protein_names_uniprotkb": "Protein Cryzl2; Crystallin zeta like 2", "protein_names_refseq": "protein Cryzl2; quinone oxidoreductase-like protein 2; tumor protein p53 inducible protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:289138)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNC9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B3GNI6-1", "uniprot_id": [ { "id": "SEP11_RAT", "url": "https://www.uniprot.org/uniprot/B3GNI6", "type": "external" } ], "mass": 49695.0, "length": 431, "protein_name": "Septin-11", "gene_name": "Septin11", "organism": "Rat", "refseq_name": "septin-11", "refseq_ac": [ { "id": "NP_001100678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100678", "type": "external" } ], "gene_names_uniprotkb": "Septin11; Sept11", "gene_names_refseq": "Sept11; Septin11", "protein_names_uniprotkb": "Septin-11", "protein_names_refseq": "septin-11", "tax_id": 10116, "disease": "", "pathway": " (rno:305227)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15196925;15485874;17546647;18683930;19380581", "class_list": "", "function": "Electron microscopy immunocytochemistry of the cerebellum revealed the accumulation of septin 11 at the neck of dendritic spines, at the bifurcation of dendritic branches, and at some GABAergic synapses., [RefSeq, PubMed]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity., [UniProtKB, PubMed]; SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling, [RefSeq, PubMed]; Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DMA8;B3GNI4", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005940 septin ring;GO:0030424 axon;GO:0043197 dendritic spine", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0050807 regulation of synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "B3GNI6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5R7-1", "uniprot_id": [ { "id": "REXO5_RAT", "url": "https://www.uniprot.org/uniprot/A1A5R7", "type": "external" } ], "mass": 86052.0, "length": 754, "protein_name": "RNA exonuclease 5", "gene_name": "Rexo5", "organism": "Rat", "refseq_name": "RNA exonuclease 5", "refseq_ac": [ { "id": "NP_001073174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073174", "type": "external" } ], "gene_names_uniprotkb": "Rexo5; Exnef", "gene_names_refseq": "2610020h08rik; Exnef; RGD1305412; Rexo5", "protein_names_uniprotkb": "RNA exonuclease 5; 3.1.-.-; Putative RNA exonuclease NEF-sp", "protein_names_refseq": "RNA exonuclease 5; putative RNA exonuclease NEF-sp", "tax_id": 10116, "disease": "", "pathway": " (rno:309036)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004527 exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0031125 rRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5R7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1I3-1", "uniprot_id": [ { "id": "NUMBL_RAT", "url": "https://www.uniprot.org/uniprot/A1L1I3", "type": "external" } ], "mass": 65513.0, "length": 614, "protein_name": "Numb-like protein", "gene_name": "Numbl", "organism": "Rat", "refseq_name": "numb-like protein isoform 1", "refseq_ac": [ { "id": "NP_001385626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385626", "type": "external" } ], "gene_names_uniprotkb": "Numbl; Nbl", "gene_names_refseq": "Numbl", "protein_names_uniprotkb": "Numb-like protein", "protein_names_refseq": "numb homolog-like; numb-like protein isoform 1; numb-like protein", "tax_id": 10116, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "18299187;20079715;21150807;22437994;22673903;38843836", "class_list": "", "function": "Peripheral nerve injury induced a downregulation of Numbl in the sciatic nerve, which was associated with Schwann cell differentiation., [RefSeq, PubMed]; Plays a role in the process of neurogenesis., [UniProtKB, UniProtKB]; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons (By similarity)., [UniProtKB]; We show that NUMBL is expressed in the rat auditory sensory epithelium during cochlear development, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm", "go_biological_process": "GO:0007399 nervous system development;GO:0007409 axonogenesis;GO:0030900 forebrain development;GO:0034332 adherens junction organization;GO:0050775 positive regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A1L1I3-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVU1-1", "uniprot_id": [ { "id": "SPRTN_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVU1", "type": "external" } ], "mass": 55024.0, "length": 496, "protein_name": "DNA-dependent metalloprotease SPRTN", "gene_name": "Sprtn", "organism": "Rat", "refseq_name": "DNA-dependent metalloprotease SPRTN", "refseq_ac": [ { "id": "NP_001386111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386111", "type": "external" } ], "gene_names_uniprotkb": "Sprtn", "gene_names_refseq": "RGD1559496; Sprtn", "protein_names_uniprotkb": "DNA-dependent metalloprotease SPRTN; 3.4.24.-; Protein with SprT-like domain at the N terminus; Spartan", "protein_names_refseq": "DNA-dependent metalloprotease SPRTN; protein with SprT-like domain at the N terminus; spartan; sprT-like domain-containing protein Spartan", "tax_id": 10116, "disease": "Ruijs-Aalfs syndrome (Disease Ontology:DOID:0111264)", "pathway": " (rno:292101); (R-RNO-110320)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis. Catalyzes proteolytic cleavage of the HMCES DNA-protein cross-link following unfolding by the BRIP1/FANCJ helicase. Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4. Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs. Involved in recruitment of VCP/p97 to sites of DNA damage. Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation. Does not activate CHEK1 in response to DNA damage. May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003690 double-stranded DNA binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin", "go_biological_process": "GO:0006508 proteolysis;GO:0006974 DNA damage response;GO:0009411 response to UV;GO:0031398 positive regulation of protein ubiquitination;GO:0016540 protein autoprocessing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVU1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LM81-1", "uniprot_id": [ { "id": "TM1L1_RAT", "url": "https://www.uniprot.org/uniprot/F1LM81", "type": "external" } ], "mass": 52551.0, "length": 475, "protein_name": "TOM1-like protein 1", "gene_name": "Tom1l1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tom1l1; Srcasm", "gene_names_refseq": "", "protein_names_uniprotkb": "TOM1-like protein 1; Src-activating and signaling molecule protein; Target of Myb-like protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "17977829;22673903", "class_list": "", "function": "Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity;GO:0030276 clathrin binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0015031 protein transport;GO:0032147 activation of protein kinase activity;GO:0045839 negative regulation of mitotic nuclear division;GO:0031954 positive regulation of protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1LM81-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JPN2-1", "uniprot_id": [ { "id": "S39A4_RAT", "url": "https://www.uniprot.org/uniprot/A0JPN2", "type": "external" } ], "mass": 71253.0, "length": 657, "protein_name": "Zinc transporter ZIP4", "gene_name": "Slc39a4", "organism": "Rat", "refseq_name": "zinc transporter ZIP4 precursor", "refseq_ac": [ { "id": "NP_001071137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071137", "type": "external" } ], "gene_names_uniprotkb": "Slc39a4; Zip4", "gene_names_refseq": "Slc39a4", "protein_names_uniprotkb": "Zinc transporter ZIP4; Solute carrier family 39 member 4; ZIP-4; Zrt- and Irt-like protein 4", "protein_names_refseq": "ZIP-4; solute carrier family 39 (zinc transporter), member 4; zinc transporter ZIP4 precursor; zinc transporter ZIP4; zrt- and Irt-like protein 4", "tax_id": 10116, "disease": "acrodermatitis enteropathica (Disease Ontology:DOID:0050605)", "pathway": " (rno:300051); (R-RNO-442380)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "19530166;21454685;22466565;23013362;26702153", "class_list": "", "function": "Chronic alcohol exposure decreases Kruppel-like factor (KLF)4 and ZIP4 expression and consequently decreases zinc transport into cells which, in turn, impairs their function., [RefSeq, PubMed]; Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine. The Zn(2+) uniporter activity is regulated by zinc availability. Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The localization of zip1 and zip4 was examined in the brains of adult rats, [RefSeq, PubMed]; The rapid upregulation of Zip4 expression in the small intestine during zinc deficient conditions corroborates the important role of Zip4 in the systemic control of zinc homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0106219 zinc ion sensor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0006882 intracellular zinc ion homeostasis;GO:0030003 intracellular monoatomic cation homeostasis;GO:0034224 cellular response to zinc ion starvation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0JPN2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZN43-1", "uniprot_id": [ { "id": "NDUF6_RAT", "url": "https://www.uniprot.org/uniprot/D3ZN43", "type": "external" } ], "mass": 38515.0, "length": 333, "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "gene_name": "Ndufaf6", "organism": "Rat", "refseq_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor", "refseq_ac": [ { "id": "NP_001263370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263370", "type": "external" } ], "gene_names_uniprotkb": "Ndufaf6", "gene_names_refseq": "Ndufaf6; RGD1309085", "protein_names_uniprotkb": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "tax_id": 10116, "disease": "Fanconi renotubular syndrome 5 (Disease Ontology:DOID:0080761); nuclear type mitochondrial complex I deficiency 17 (Disease Ontology:DOID:0112078); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:297821); (R-RNO-6799198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "20552642", "class_list": "", "function": "Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of complex I subunit MT-ND1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This review summarizes the current model of human complex I assembly and the roles played by different assembly factors at early, mid, and late assembly stages. For complex I assembly to proceed effectively in forming the holoenzyme, a group of proteins termed ''assembly factors'' are required. Defects in assembly factors which disrupt complex I assembly may contribute to human disease pathogenesis. Review article, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZN43-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5P2-1", "uniprot_id": [ { "id": "RRS1_RAT", "url": "https://www.uniprot.org/uniprot/A1A5P2", "type": "external" } ], "mass": 41537.0, "length": 365, "protein_name": "Ribosome biogenesis regulatory protein homolog", "gene_name": "Rrs1", "organism": "Rat", "refseq_name": "ribosome biogenesis regulatory protein homolog", "refseq_ac": [ { "id": "NP_001073167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073167", "type": "external" } ], "gene_names_uniprotkb": "Rrs1", "gene_names_refseq": "Rrs1", "protein_names_uniprotkb": "Ribosome biogenesis regulatory protein homolog", "protein_names_refseq": "RRS1 ribosome biogenesis regulator homolog; ribosome biogenesis regulator 1 homolog; ribosome biogenesis regulatory protein homolog", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (rno:297784)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A5P2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VD13-1", "uniprot_id": [ { "id": "PTCD1_RAT", "url": "https://www.uniprot.org/uniprot/A2VD13", "type": "external" } ], "mass": 77121.0, "length": 686, "protein_name": "Pentatricopeptide repeat-containing protein 1, mitochondrial", "gene_name": "Ptcd1", "organism": "Rat", "refseq_name": "pentatricopeptide repeat-containing protein 1, mitochondrial", "refseq_ac": [ { "id": "NP_001388048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001388048", "type": "external" } ], "gene_names_uniprotkb": "Ptcd1", "gene_names_refseq": "Ptcd1", "protein_names_uniprotkb": "Pentatricopeptide repeat-containing protein 1, mitochondrial", "protein_names_refseq": "pentatricopeptide repeat-containing protein 1, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:304278)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19651879;29393594", "class_list": "", "function": "Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity. Also affects the 3'-processing of mitochondrial tRNAs., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0042780 tRNA 3'-end processing;GO:1900864 mitochondrial RNA modification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2VD13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN18-1", "uniprot_id": [ { "id": "PFD2_RAT", "url": "https://www.uniprot.org/uniprot/B0BN18", "type": "external" } ], "mass": 16580.0, "length": 154, "protein_name": "Prefoldin subunit 2", "gene_name": "Pfdn2", "organism": "Rat", "refseq_name": "prefoldin subunit 2", "refseq_ac": [ { "id": "NP_001102946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102946", "type": "external" } ], "gene_names_uniprotkb": "Pfdn2", "gene_names_refseq": "Pfdn2", "protein_names_uniprotkb": "Prefoldin subunit 2", "protein_names_refseq": "prefoldin 2; prefoldin subunit 2", "tax_id": 10116, "disease": "", "pathway": " (rno:685607)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0001540 amyloid-beta binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0051495 positive regulation of cytoskeleton organization;GO:0006457 protein folding;GO:1905907 negative regulation of amyloid fibril formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B0BN18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BN93-1", "uniprot_id": [ { "id": "PSD13_RAT", "url": "https://www.uniprot.org/uniprot/B0BN93", "type": "external" } ], "mass": 42817.0, "length": 376, "protein_name": "26S proteasome non-ATPase regulatory subunit 13", "gene_name": "Psmd13", "organism": "Rat", "refseq_name": "26S proteasome non-ATPase regulatory subunit 13", "refseq_ac": [ { "id": "NP_001102395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102395", "type": "external" } ], "gene_names_uniprotkb": "Psmd13", "gene_names_refseq": "Psmd13", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 13; 26S proteasome regulatory subunit RPN9; 26S proteasome regulatory subunit S11; 26S proteasome regulatory subunit p40.5", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 13; 26S proteasome regulatory subunit RPN9; 26S proteasome regulatory subunit S11; 26S proteasome regulatory subunit p40.5; proteasome (prosome, macropain) 26S subunit, non-ATPase, 13", "tax_id": 10116, "disease": "", "pathway": " (rno:365388); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-6798695); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 57, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0008021 synaptic vesicle;GO:0000502 proteasome complex", "go_biological_process": "GO:0010498 proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:2000311 regulation of AMPA receptor activity;GO:0007127 meiosis I", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BN93-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNG2-1", "uniprot_id": [ { "id": "TM6S2_RAT", "url": "https://www.uniprot.org/uniprot/B0BNG2", "type": "external" } ], "mass": 42574.0, "length": 378, "protein_name": "Transmembrane 6 superfamily member 2", "gene_name": "Tm6sf2", "organism": "Rat", "refseq_name": "transmembrane 6 superfamily member 2", "refseq_ac": [ { "id": "NP_001121126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121126", "type": "external" } ], "gene_names_uniprotkb": "Tm6sf2", "gene_names_refseq": "Tm6sf2", "protein_names_uniprotkb": "Transmembrane 6 superfamily member 2", "protein_names_refseq": "transmembrane 6 superfamily member 2", "tax_id": 10116, "disease": "steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:689029)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNG2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0K004-1", "uniprot_id": [ { "id": "S35G3_RAT", "url": "https://www.uniprot.org/uniprot/B0K004", "type": "external" } ], "mass": 35687.0, "length": 340, "protein_name": "Solute carrier family 35 member G3", "gene_name": "Slc35g3", "organism": "Rat", "refseq_name": "solute carrier family 35 member G3", "refseq_ac": [ { "id": "NP_001121130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121130", "type": "external" } ], "gene_names_uniprotkb": "Slc35g3; Amac1", "gene_names_refseq": "Amac1; Slc35g3", "protein_names_uniprotkb": "Solute carrier family 35 member G3; Acyl-malonyl-condensing enzyme 1", "protein_names_refseq": "acyl-malonyl condensing enzyme; acyl-malonyl-condensing enzyme 1; protein AMAC1; solute carrier family 35 member G3", "tax_id": 10116, "disease": "", "pathway": " (rno:691976)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Testis-specific UDP-N-acetylglucosamine transporter that mediates transport of nucleotide sugars to facilitate the proper glycosylation of proteins critical for sperm function., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0K004-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1H278-1", "uniprot_id": [ { "id": "TRI11_RAT", "url": "https://www.uniprot.org/uniprot/B1H278", "type": "external" } ], "mass": 52554.0, "length": 467, "protein_name": "E3 ubiquitin-protein ligase TRIM11", "gene_name": "Trim11", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM11", "refseq_ac": [ { "id": "NP_001386475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386475", "type": "external" } ], "gene_names_uniprotkb": "Trim11", "gene_names_refseq": "Trim11", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM11; 2.3.2.27; Tripartite motif-containing protein 11", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM11; RING-type E3 ubiquitin transferase TRIM11; tripartite motif protein 11; tripartite motif-containing protein 11", "tax_id": 10116, "disease": "", "pathway": " (rno:360534); (R-RNO-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway (By similarity). Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Acts as an inhibitor of the AIM2 inflammasome by promoting autophagy-dependent degradation of AIM2. Mechanistically, undergoes autoubiquitination upon DNA stimulation, promoting interaction with AIM2 and SQSTM1/p62, leading to AIM2 recruitment to autophagosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:0045892 negative regulation of DNA-templated transcription;GO:0046598 positive regulation of viral entry into host cell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B1H278-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WBU5-1", "uniprot_id": [ { "id": "SBK2_RAT", "url": "https://www.uniprot.org/uniprot/B1WBU5", "type": "external" } ], "mass": 39773.0, "length": 362, "protein_name": "Serine/threonine-protein kinase SBK2", "gene_name": "Sbk2", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase SBK2", "refseq_ac": [ { "id": "NP_001121011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121011", "type": "external" } ], "gene_names_uniprotkb": "Sbk2", "gene_names_refseq": "RGD1563279; Sbk2", "protein_names_uniprotkb": "Serine/threonine-protein kinase SBK2; 2.7.11.1; SH3 domain-binding kinase family member 2", "protein_names_refseq": "SH3-binding domain kinase family, member 2; serine/threonine-protein kinase SBK2", "tax_id": 10116, "disease": "", "pathway": " (rno:691411)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "", "go_biological_process": "GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WBU5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B1WC39-1", "uniprot_id": [ { "id": "TIGD5_RAT", "url": "https://www.uniprot.org/uniprot/B1WC39", "type": "external" } ], "mass": 70268.0, "length": 642, "protein_name": "Tigger transposable element derived 5", "gene_name": "Tigd5", "organism": "Rat", "refseq_name": "tigger transposable element derived 5", "refseq_ac": [ { "id": "NP_001119740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119740", "type": "external" } ], "gene_names_uniprotkb": "Tigd5", "gene_names_refseq": "Tigd5", "protein_names_uniprotkb": "Tigger transposable element derived 5", "protein_names_refseq": "tigger transposable element derived 5 homolog; tigger transposable element derived 5; tigger transposable element-derived protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:300034)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007379 segment specification;GO:0021556 central nervous system formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B1WC39-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV71-1", "uniprot_id": [ { "id": "NDUF5_RAT", "url": "https://www.uniprot.org/uniprot/B2GV71", "type": "external" } ], "mass": 38229.0, "length": 343, "protein_name": "Arginine-hydroxylase NDUFAF5, mitochondrial", "gene_name": "Ndufaf5", "organism": "Rat", "refseq_name": "arginine-hydroxylase NDUFAF5, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001119843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119843", "type": "external" } ], "gene_names_uniprotkb": "Ndufaf5", "gene_names_refseq": "Ndufaf5; RGD1309829", "protein_names_uniprotkb": "Arginine-hydroxylase NDUFAF5, mitochondrial; 1.-.-.-; 2.1.1.-; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5; Putative methyltransferase NDUFAF5", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5; arginine-hydroxylase NDUFAF5, mitochondrial precursor; arginine-hydroxylase NDUFAF5, mitochondrial; probable methyltransferase C20orf7 homolog, mitochondrial; putative methyltransferase NDUFAF5", "tax_id": 10116, "disease": "nuclear type mitochondrial complex I deficiency 16 (Disease Ontology:DOID:0112096)", "pathway": " (rno:296190); (R-RNO-6799198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Arginine hydroxylase that mediates hydroxylation of 'Arg-111' of NDUFS7 and is involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. May also have methyltransferase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0099617 matrix side of mitochondrial inner membrane", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GV71-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYI0-1", "uniprot_id": [ { "id": "WDR91_RAT", "url": "https://www.uniprot.org/uniprot/B2RYI0", "type": "external" } ], "mass": 83146.0, "length": 747, "protein_name": "WD repeat-containing protein 91", "gene_name": "Wdr91", "organism": "Rat", "refseq_name": "WD repeat-containing protein 91", "refseq_ac": [ { "id": "NP_001120770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120770", "type": "external" } ], "gene_names_uniprotkb": "Wdr91", "gene_names_refseq": "RGD1306697; Wdr91", "protein_names_uniprotkb": "WD repeat-containing protein 91", "protein_names_refseq": "WD repeat-containing protein 91", "tax_id": 10116, "disease": "", "pathway": " (rno:312225)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035014 phosphatidylinositol 3-kinase regulator activity;GO:0141039 phosphatidylinositol 3-kinase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0045022 early endosome to late endosome transport;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYI0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYT9-1", "uniprot_id": [ { "id": "TACO1_RAT", "url": "https://www.uniprot.org/uniprot/B2RYT9", "type": "external" } ], "mass": 32754.0, "length": 295, "protein_name": "Translational activator of cytochrome c oxidase 1", "gene_name": "Taco1", "organism": "Rat", "refseq_name": "translational activator of cytochrome c oxidase 1", "refseq_ac": [ { "id": "NP_001101772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101772", "type": "external" } ], "gene_names_uniprotkb": "Taco1; Ccdc44", "gene_names_refseq": "Ccdc44; RGD1306784; Taco1", "protein_names_uniprotkb": "Translational activator of cytochrome c oxidase 1; Coiled-coil domain-containing protein 44; Translational activator of mitochondrially-encoded cytochrome c oxidase I", "protein_names_refseq": "coiled-coil domain containing 44; coiled-coil domain-containing protein 44; translational activator of cytochrome c oxidase 1; translational activator of mitochondrially-encoded cytochrome c oxidase I", "tax_id": 10116, "disease": "mitochondrial complex IV deficiency nuclear type 8 (Disease Ontology:DOID:0070495); atrial heart septal defect 8 (Disease Ontology:DOID:0110113); ventricular septal defect (Disease Ontology:DOID:1657); congenital heart disease (Disease Ontology:DOID:1682); brain ischemia (Disease Ontology:DOID:2316); osteosarcoma (Disease Ontology:DOID:3347); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (rno:360645)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019843 rRNA binding;GO:0097177 mitochondrial ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0061743 motor learning;GO:0070129 regulation of mitochondrial translation;GO:1904959 regulation of cytochrome-c oxidase activity;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0070131 positive regulation of mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYT9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RYU6-1", "uniprot_id": [ { "id": "TPC2L_RAT", "url": "https://www.uniprot.org/uniprot/B2RYU6", "type": "external" } ], "mass": 16032.0, "length": 139, "protein_name": "Trafficking protein particle complex subunit 2-like protein", "gene_name": "Trappc2l", "organism": "Rat", "refseq_name": "trafficking protein particle complex subunit 2-like protein", "refseq_ac": [ { "id": "NP_001099663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099663", "type": "external" } ], "gene_names_uniprotkb": "Trappc2l", "gene_names_refseq": "RGD1304906; Trappc2l", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 2-like protein", "protein_names_refseq": "trafficking protein particle complex 2-like; trafficking protein particle complex subunit 2-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:292074); (R-RNO-204005); (R-RNO-8876198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2RYU6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2RZ37-1", "uniprot_id": [ { "id": "REEP5_RAT", "url": "https://www.uniprot.org/uniprot/B2RZ37", "type": "external" } ], "mass": 21431.0, "length": 189, "protein_name": "Receptor expression-enhancing protein 5", "gene_name": "Reep5", "organism": "Rat", "refseq_name": "receptor expression-enhancing protein 5", "refseq_ac": [ { "id": "NP_001102358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102358", "type": "external" } ], "gene_names_uniprotkb": "Reep5; Dp1", "gene_names_refseq": "Dp1; Reep5", "protein_names_uniprotkb": "Receptor expression-enhancing protein 5; Polyposis locus protein 1 homolog", "protein_names_refseq": "deleted in polyposis 1; polyposis locus protein 1 homolog; receptor expression-enhancing protein 5", "tax_id": 10116, "disease": "hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782)", "pathway": " (rno:364838)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19665976;22673903;29393594;29431104", "class_list": "", "function": "Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; REEP5 modulates cardiac function by shaping the sarcoplasmic reticulum. REEP5 defect deforms the SR architecture to depress cardiac contractility in heart failure. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0014701 junctional sarcoplasmic reticulum membrane;GO:0033017 sarcoplasmic reticulum membrane;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0090158 endoplasmic reticulum membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B2RZ37-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DF93-1", "uniprot_id": [ { "id": "PATL1_RAT", "url": "https://www.uniprot.org/uniprot/B5DF93", "type": "external" } ], "mass": 86869.0, "length": 770, "protein_name": "Protein PAT1 homolog 1", "gene_name": "Patl1", "organism": "Rat", "refseq_name": "protein PAT1 homolog 1", "refseq_ac": [ { "id": "NP_001101990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101990", "type": "external" } ], "gene_names_uniprotkb": "Patl1", "gene_names_refseq": "Pat1b; Patl1; RGD1305514", "protein_names_uniprotkb": "Protein PAT1 homolog 1; PAT1-like protein 1; Pat1b; Protein PAT1 homolog b", "protein_names_refseq": "PAT1-like protein 1; protein PAT1 homolog 1; protein PAT1 homolog b; protein associated with topoisomerase II homolog 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361736); (R-RNO-430039)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008266 poly(U) RNA binding;GO:0034046 poly(G) binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0000932 P-body;GO:0016605 PML body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0033962 P-body assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DF93-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFH9-1", "uniprot_id": [ { "id": "T150C_RAT", "url": "https://www.uniprot.org/uniprot/B5DFH9", "type": "external" } ], "mass": 27815.0, "length": 249, "protein_name": "Transmembrane protein 150C", "gene_name": "Tmem150c", "organism": "Rat", "refseq_name": "transmembrane protein 150C", "refseq_ac": [ { "id": "NP_001101824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101824", "type": "external" } ], "gene_names_uniprotkb": "Tmem150c", "gene_names_refseq": "RGD1306105; Tmem150c", "protein_names_uniprotkb": "Transmembrane protein 150C", "protein_names_refseq": "transmembrane protein 150C", "tax_id": 10116, "disease": "", "pathway": " (rno:360916)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Nonselective cationic channel with high permeability to Ca(2+). Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0140135 mechanosensitive monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0071260 cellular response to mechanical stimulus;GO:0019230 proprioception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DFH9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DFI8-1", "uniprot_id": [ { "id": "UBE2S_RAT", "url": "https://www.uniprot.org/uniprot/B5DFI8", "type": "external" } ], "mass": 24215.0, "length": 223, "protein_name": "Ubiquitin-conjugating enzyme E2 S", "gene_name": "Ube2s", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 S", "refseq_ac": [ { "id": "NP_001099694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099694", "type": "external" } ], "gene_names_uniprotkb": "Ube2s", "gene_names_refseq": "RGD1564746; Ube2s", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 S; 2.3.2.23; E2 ubiquitin-conjugating enzyme S; Ubiquitin carrier protein S; Ubiquitin-protein ligase S", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme S; ubiquitin carrier protein S; ubiquitin-conjugating enzyme E2 S; ubiquitin-protein ligase S", "tax_id": 10116, "disease": "", "pathway": " (rno:292588); (R-RNO-141430); (R-RNO-174048); (R-RNO-174084); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-176407); (R-RNO-176408); (R-RNO-176412); (R-RNO-179409); (R-RNO-2467813); (R-RNO-2559582); (R-RNO-68867); (R-RNO-69017); (R-RNO-8866652); (R-RNO-983168)", "pathway_count": 17, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity;GO:0010997 anaphase-promoting complex binding;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B5DFI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZCL3-1", "uniprot_id": [ { "id": "RU1C_RAT", "url": "https://www.uniprot.org/uniprot/D3ZCL3", "type": "external" } ], "mass": 17364.0, "length": 159, "protein_name": "U1 small nuclear ribonucleoprotein C", "gene_name": "Snrpc", "organism": "Rat", "refseq_name": "U1 small nuclear ribonucleoprotein C", "refseq_ac": [ { "id": "NP_001257969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257969", "type": "external" } ], "gene_names_uniprotkb": "Snrpc; SNRPC", "gene_names_refseq": "Snrp1c; Snrpc; U1-C; U1C", "protein_names_uniprotkb": "U1 small nuclear ribonucleoprotein C; U1 snRNP C; U1-C; U1C", "protein_names_refseq": "U1 small nuclear ribonucleoprotein C; U1 snRNP C", "tax_id": 10116, "disease": "mixed connective tissue disease (Disease Ontology:DOID:3492); connective tissue disease (Disease Ontology:DOID:65); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:361808); (R-RNO-9770562)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030627 pre-mRNA 5'-splice site binding;GO:1990446 U1 snRNP binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0015030 Cajal body;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome;GO:0000395 mRNA 5'-splice site recognition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZCL3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZDK7-1", "uniprot_id": [ { "id": "PGP_RAT", "url": "https://www.uniprot.org/uniprot/D3ZDK7", "type": "external" } ], "mass": 34601.0, "length": 321, "protein_name": "Phosphoglycolate phosphatase", "gene_name": "Pgp", "organism": "Rat", "refseq_name": "glycerol-3-phosphate phosphatase", "refseq_ac": [ { "id": "NP_001162623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162623", "type": "external" } ], "gene_names_uniprotkb": "Pgp", "gene_names_refseq": "AUM; G3PP; Pgp; RGD1307773", "protein_names_uniprotkb": "Phosphoglycolate phosphatase; 3.1.3.18; 3.1.3.21; 3.1.3.48; AUM; Aspartate-based ubiquitous Mg(2+)-dependent phosphatase; G3PP; Glycerol-3-phosphate phosphatase", "protein_names_refseq": "aspartate-based ubiquitous Mg(2+)-dependent phosphatase; glycerol-3-phosphate phosphatase", "tax_id": 10116, "disease": "", "pathway": " (rno:287115); (R-RNO-1483206)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;26755581", "class_list": "", "function": "Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, also has a phosphatase activity toward ADP, ATP, GDP and GTP., [UniProtKB, UniProtKB]; In vivo overexpression of PGP (functioning as glycerol-3-phosphate phosphatase) in rat liver lowers body weight gain and hepatic glucose production from glycerol and elevates plasma HDL levels. It is expressed in different tissues and nutritional states., [RefSeq, PubMed]; Phosphatase with activity against multiple substrates (By similarity). Acts as a metabolite repair enzyme which eliminates toxic glycolytic side products (By similarity). Dephosphorylates 2-phosphoglycolate which is generated during the repair of oxidative DNA lesions (By similarity). This controls triosephosphate isomerase activity, glycerolipid partitioning and cell proliferation in the embryo and is required for embryonic development (By similarity). Dephosphorylates 4-phosphoerythronate, a side product which is produced by GAPDH and which inhibits 6-phosphogluconate dehydrogenase (By similarity). Dephosphorylation of 4-phosphoerythronate prevents the accumulation of high 4-phosphoerythronate levels which would otherwise inhibit the pentose phosphate pathway (By similarity). Dephosphorylates 2-phospho-L-lactate which is a product of a pyruvate kinase side reaction (By similarity). This prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur (By similarity). Has glycerol-3-phosphate phosphatase activity, hydrolyzing glycerol-3-phosphate into glycerol and thereby regulating the cellular levels of glycerol-3-phosphate, a metabolic intermediate of glucose, lipid and energy metabolism (By similarity). Has been shown to have tyrosine-protein phosphatase activity although the physiological relevance is unclear (By similarity). In vitro, has phosphatase activity toward ADP, ATP, GDP and GTP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0008967 phosphoglycolate phosphatase activity;GO:0043262 ADP phosphatase activity;GO:0000121 sn-glycerol 1-phosphatase activity;GO:0043136 sn-glycerol 3-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0006114 glycerol biosynthetic process;GO:0045721 negative regulation of gluconeogenesis;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZDK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZLH5-1", "uniprot_id": [ { "id": "PLXB3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZLH5", "type": "external" } ], "mass": 208487.0, "length": 1902, "protein_name": "Plexin-B3", "gene_name": "Plxnb3", "organism": "Rat", "refseq_name": "plexin-B3 precursor", "refseq_ac": [ { "id": "NP_001129350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129350", "type": "external" } ], "gene_names_uniprotkb": "Plxnb3", "gene_names_refseq": "Plxnb3; RGD1560615", "protein_names_uniprotkb": "Plexin-B3; Protein Plxnb3", "protein_names_refseq": "plexin-B3 precursor; protein Plxnb3", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:363517); (R-RNO-416700)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20696765;25989221;34267322", "class_list": "", "function": "Essential roles of plexin-B3(+) oligodendrocyte precursor cells in the pathogenesis of Alzheimer's disease. Erratum:[Commun Biol. 2021 Dec 2;4(1):1372. doi: 10.1038/s42003-021-02905-5. PMID: 34857866] Publication Status: Online-Only, [RefSeq, PubMed]; Plexin-B3 contributes to regulating synapse formation., [RefSeq, PubMed]; Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1., [UniProtKB, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 9, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0017154 semaphorin receptor activity;GO:0098632 cell-cell adhesion mediator activity;GO:0051022 Rho GDP-dissociation inhibitor binding", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0010976 positive regulation of neuron projection development;GO:0071526 semaphorin-plexin signaling pathway;GO:0030336 negative regulation of cell migration;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D3ZLH5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTL1-1", "uniprot_id": [ { "id": "PO4F3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTL1", "type": "external" } ], "mass": 37043.0, "length": 338, "protein_name": "POU domain, class 4, transcription factor 3", "gene_name": "Pou4f3", "organism": "Rat", "refseq_name": "POU domain, class 4, transcription factor 3", "refseq_ac": [ { "id": "NP_001102359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102359", "type": "external" } ], "gene_names_uniprotkb": "Pou4f3", "gene_names_refseq": "Pou4f3", "protein_names_uniprotkb": "POU domain, class 4, transcription factor 3", "protein_names_refseq": "POU domain, class 4, transcription factor 3", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 15 (Disease Ontology:DOID:0110546)", "pathway": " (rno:364855)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25372459;8637595", "class_list": "", "function": "Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear., [UniProtKB, UniProtKB]; These data demonstrate that Nr2f2 is a direct target of POU4F3 in vitro and that this regulatory relationship may be relevant to hair cell development and survival. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0042491 inner ear auditory receptor cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZTL1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVF4-1", "uniprot_id": [ { "id": "TPC2B_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVF4", "type": "external" } ], "mass": 16453.0, "length": 140, "protein_name": "Trafficking protein particle complex subunit 2B", "gene_name": "Trappc2b", "organism": "Rat", "refseq_name": "trafficking protein particle complex subunit 2B", "refseq_ac": [ { "id": "NP_001258040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258040", "type": "external" } ], "gene_names_uniprotkb": "Trappc2b", "gene_names_refseq": "Trappc2b", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 2B", "protein_names_refseq": "sedlin-like; trafficking protein particle complex 2; trafficking protein particle complex subunit 2-like; trafficking protein particle complex subunit 2B; trafficking protein particle complex subunit 2", "tax_id": 10116, "disease": "X-linked spondyloepiphyseal dysplasia tarda (Disease Ontology:DOID:0080362); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789)", "pathway": " (rno:100910318)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0030008 TRAPP complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVF4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVR1-1", "uniprot_id": [ { "id": "NTM1B_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVR1", "type": "external" } ], "mass": 32312.0, "length": 283, "protein_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 2", "gene_name": "Ntmt2", "organism": "Rat", "refseq_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 2", "refseq_ac": [ { "id": "NP_001363789", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001363789", "type": "external" } ], "gene_names_uniprotkb": "Ntmt2; Mettl11b", "gene_names_refseq": "Mettl11b; NTM1B; Ntmt2; RGD1564106", "protein_names_uniprotkb": "N-terminal Xaa-Pro-Lys N-methyltransferase 2; 2.1.1.299; Alpha N-terminal protein methyltransferase 1B; Methyltransferase-like protein 11B; NTM1B; X-Pro-Lys N-terminal protein methyltransferase 1B", "protein_names_refseq": "N-terminal Xaa-Pro-Lys N-methyltransferase 2; X-Pro-Lys N-terminal protein methyltransferase 1B; alpha N-terminal protein methyltransferase 1B; methyltransferase like 11B; methyltransferase-like protein 11B", "tax_id": 10116, "disease": "", "pathway": " (rno:289167)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro). May activate NTMT1 by priming its substrates for trimethylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.299", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.299", "type": "external" } ], "go_molecular_function": "GO:0071885 N-terminal protein N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006480 N-terminal protein amino acid methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVR1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZVR7-1", "uniprot_id": [ { "id": "PXL2B_RAT", "url": "https://www.uniprot.org/uniprot/D3ZVR7", "type": "external" } ], "mass": 21607.0, "length": 201, "protein_name": "Prostamide/prostaglandin F synthase", "gene_name": "Prxl2b", "organism": "Rat", "refseq_name": "prostamide/prostaglandin F synthase", "refseq_ac": [ { "id": "NP_001102167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102167", "type": "external" } ], "gene_names_uniprotkb": "Prxl2b; Fam213b", "gene_names_refseq": "Fam213b; Prxl2b; RGD1308251", "protein_names_uniprotkb": "Prostamide/prostaglandin F synthase; 1.11.1.20; Peroxiredoxin-like 2B; Prostamide/PG F synthase; Prostamide/PGF synthase", "protein_names_refseq": "family with sequence similarity 213, member B; prostamide/PG F synthase; prostamide/PGF synthase; prostamide/prostaglandin F synthase", "tax_id": 10116, "disease": "", "pathway": " (rno:362676)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.20", "type": "external" } ], "go_molecular_function": "GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0036130 prostaglandin H2 endoperoxidase reductase activity;GO:0047017 prostaglandin F synthase activity;GO:0008379 thioredoxin peroxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0019371 cyclooxygenase pathway;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZVR7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZZP4-1", "uniprot_id": [ { "id": "PRIMA_RAT", "url": "https://www.uniprot.org/uniprot/D3ZZP4", "type": "external" } ], "mass": 16495.0, "length": 153, "protein_name": "Proline-rich membrane anchor 1", "gene_name": "Prima1", "organism": "Rat", "refseq_name": "proline-rich membrane anchor 1 precursor", "refseq_ac": [ { "id": "NP_001102191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102191", "type": "external" } ], "gene_names_uniprotkb": "Prima1", "gene_names_refseq": "PRiMA; Prima1l; Prima1", "protein_names_uniprotkb": "Proline-rich membrane anchor 1; PRiMA", "protein_names_refseq": "proline-rich membrane anchor 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:690195)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "18511416;19368807;19490106;19680821;20147288", "class_list": "", "function": "Acetylcholinesterase associates differently with its anchoring proteins ColQ and PRiMA, [RefSeq, PubMed]; Data show that after denervation, the expression of PRiMA, AChE(T) and G(4) AChE decreased markedly in the spinal cord, and in fast- and slow-twitch muscles., [RefSeq, PubMed]; PRiMA in neurons has a role in targeting acetylcholinesterase to membrane rafts, [RefSeq, PubMed]; Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Organizes ACHE into tetramers (By similarity)., [UniProtKB]; These findings suggest that the restricted localization of PRiMA-linked G4 AChE at the nmjs could be contributed by the pre-synaptic motor neuron and/or the post-synaptic muscle fiber., [RefSeq, PubMed]; These results suggested that a MAP kinase signaling pathway served as one of the transcriptional regulators in controlling PRiMA gene expression during the neuronal differentiation process., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D4ACH8", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0045202 synapse;GO:0070161 anchoring junction", "go_biological_process": "GO:0051649 establishment of localization in cell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "D3ZZP4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4A9R4-1", "uniprot_id": [ { "id": "PRRT4_RAT", "url": "https://www.uniprot.org/uniprot/D4A9R4", "type": "external" } ], "mass": 93830.0, "length": 902, "protein_name": "Proline-rich transmembrane protein 4", "gene_name": "Prrt4", "organism": "Rat", "refseq_name": "proline-rich transmembrane protein 4 precursor", "refseq_ac": [ { "id": "NP_001102696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102696", "type": "external" } ], "gene_names_uniprotkb": "Prrt4", "gene_names_refseq": "Prrt4; RGD1559885", "protein_names_uniprotkb": "Proline-rich transmembrane protein 4", "protein_names_refseq": "proline-rich transmembrane protein 4 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:500059)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4A9R4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ABM4-1", "uniprot_id": [ { "id": "RFPLA_RAT", "url": "https://www.uniprot.org/uniprot/D4ABM4", "type": "external" } ], "mass": 32483.0, "length": 285, "protein_name": "Ret finger protein-like 4A", "gene_name": "Rfpl4a", "organism": "Rat", "refseq_name": "ret finger protein-like 4A", "refseq_ac": [ { "id": "NP_001099692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099692", "type": "external" } ], "gene_names_uniprotkb": "Rfpl4a; Rfpl4", "gene_names_refseq": "Rfpl4a; Rfpl4", "protein_names_uniprotkb": "Ret finger protein-like 4A", "protein_names_refseq": "ret finger protein-like 4A; ret finger protein-like 4", "tax_id": 10116, "disease": "", "pathway": " (rno:292583)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ABM4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ACX8-1", "uniprot_id": [ { "id": "PCD16_RAT", "url": "https://www.uniprot.org/uniprot/D4ACX8", "type": "external" } ], "mass": 345981.0, "length": 3291, "protein_name": "Protocadherin-16", "gene_name": "Dchs1", "organism": "Rat", "refseq_name": "protocadherin-16 precursor", "refseq_ac": [ { "id": "NP_001101014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101014", "type": "external" } ], "gene_names_uniprotkb": "Dchs1", "gene_names_refseq": "Dchs1; Pcdh16", "protein_names_uniprotkb": "Protocadherin-16; Protein dachsous homolog 1", "protein_names_refseq": "dachsous 1; protein dachsous homolog 1; protocadherin 16 dachsous-like; protocadherin-16 precursor; protocadherin-16", "tax_id": 10116, "disease": "Van Maldergem syndrome 1 (Disease Ontology:DOID:0080585); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:308912)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation (By similarity)., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0045177 apical part of cell;GO:0016342 catenin complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0072006 nephron development;GO:0043931 ossification involved in bone maturation;GO:0072137 condensed mesenchymal cell proliferation;GO:0003192 mitral valve formation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "D4ACX8-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AE59-1", "uniprot_id": [ { "id": "STK11_RAT", "url": "https://www.uniprot.org/uniprot/D4AE59", "type": "external" } ], "mass": 49246.0, "length": 436, "protein_name": "Serine/threonine-protein kinase STK11", "gene_name": "Stk11", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase STK11", "refseq_ac": [ { "id": "NP_001101539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101539", "type": "external" } ], "gene_names_uniprotkb": "Stk11; Lkb1", "gene_names_refseq": "Lkb1; Stk11", "protein_names_uniprotkb": "Serine/threonine-protein kinase STK11; 2.7.11.1; LKB1; Liver kinase B1 homolog", "protein_names_refseq": "liver kinase B1 homolog; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; serine/threonine-protein kinase STK11", "tax_id": 10116, "disease": "endometrial cancer (Disease Ontology:DOID:1380); pancreatic cancer (Disease Ontology:DOID:1793); breast carcinoma (Disease Ontology:DOID:3459); cervical mucinous adenocarcinoma (Disease Ontology:DOID:3701); Peutz-Jeghers syndrome (Disease Ontology:DOID:3852); ovarian carcinoma (Disease Ontology:DOID:4001); familial melanoma (Disease Ontology:DOID:6846); hyperthyroidism (Disease Ontology:DOID:7998); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:314621); (R-RNO-380972); (R-RNO-6804756)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "14511394;18687677;18774945;22673903;31181335;31939452;32900241;35311465;38105470", "class_list": "", "function": "CD4(+) T-Cell Endogenous Cystathionine gamma Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation., [RefSeq, PubMed]; Has a role in spermiogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Interaction of Nuclear Receptor Subfamily 4 Group A Member 1 (Nr4a1) and Liver Linase B1 (LKB1) Mitigates Type 2 Diabetes Mellitus by Activating Monophosphate-Activated Protein Kinase (AMPK)/Sirtuin 1 (SIRT1) Axis and Inhibiting Nuclear Factor-kappa B (NF-kappaB) Activation. Publication Status: Online-Only, [RefSeq, PubMed]; LKB1 and CRMP1 cooperatively promote the repair of the sciatic nerve injury., [RefSeq, PubMed]; Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against hypoxia-reperfusion injury in vitro by activating liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling., [RefSeq, PubMed]; Paeoniflorin mitigated the intestinal I/R-impaired autophagy flux by activating LKB1/AMPK signaling pathway., [RefSeq, PubMed]; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0H2UI02;D4A179", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030295 protein kinase activator activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:1902554 serine/threonine protein kinase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0071493 cellular response to UV-B;GO:0006468 protein phosphorylation;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "D4AE59-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1LM93-1", "uniprot_id": [ { "id": "YES_RAT", "url": "https://www.uniprot.org/uniprot/F1LM93", "type": "external" } ], "mass": 60614.0, "length": 541, "protein_name": "Tyrosine-protein kinase Yes", "gene_name": "Yes1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Yes1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase Yes; 2.7.10.2; p61-Yes", "protein_names_refseq": "", "tax_id": 10116, "disease": "intestinal cancer (Disease Ontology:DOID:10155); Goldenhar syndrome (Disease Ontology:DOID:2907); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-1227986); (R-RNO-1433557); (R-RNO-1433559); (R-RNO-2029481); (R-RNO-210990); (R-RNO-389356); (R-RNO-389513); (R-RNO-3928662); (R-RNO-3928663); (R-RNO-3928665); (R-RNO-912631)", "pathway_count": 11, "publication_count": 4, "publication_id_list": "12640114;1709169;21256972;22673903", "class_list": "", "function": "Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis (By similarity). Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071300 cellular response to retinoic acid;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1LM93-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08602-1", "uniprot_id": [ { "id": "PGTA_RAT", "url": "https://www.uniprot.org/uniprot/Q08602", "type": "external" } ], "mass": 64904.0, "length": 567, "protein_name": "Geranylgeranyl transferase type-2 subunit alpha", "gene_name": "Rabggta", "organism": "Rat", "refseq_name": "geranylgeranyl transferase type-2 subunit alpha", "refseq_ac": [ { "id": "NP_113842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113842", "type": "external" } ], "gene_names_uniprotkb": "Rabggta; Ggta", "gene_names_refseq": "Rabggta", "protein_names_uniprotkb": "Geranylgeranyl transferase type-2 subunit alpha; 2.5.1.60; Geranylgeranyl transferase type II subunit alpha; Rab GG transferase alpha; Rab GGTase alpha; Rab geranyl-geranyltransferase subunit alpha; Rab geranylgeranyltransferase subunit alpha", "protein_names_refseq": "Rab geranylgeranyl transferase, a subunit; Rab geranylgeranyltransferase alpha; Rab geranylgeranyltransferase, alpha subunit; geranylgeranyl transferase type II subunit alpha; geranylgeranyl transferase type-2 subunit alpha; rab GG transferase alpha; rab GGTase alpha; rab geranyl-geranyltransferase subunit alpha", "tax_id": 10116, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (rno:58983); (R-RNO-6803205); (R-RNO-8873719)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10745007;11675392;12620235;18399557;18756270;19894725;21520375;22963166;23114750;29393594;8505342", "class_list": "", "function": "Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; SiRNA-mediated knockdown of alpha- or beta-subunits of RGGT and REP1 markedly attenuates glucose-stimulated insulin secretion in insulin 832/13 cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0004663 Rab geranylgeranyltransferase activity;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005968 Rab-protein geranylgeranyltransferase complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0018344 protein geranylgeranylation;GO:0097354 prenylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q08602-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20786-1", "uniprot_id": [ { "id": "PGFRA_RAT", "url": "https://www.uniprot.org/uniprot/P20786", "type": "external" } ], "mass": 122642.0, "length": 1088, "protein_name": "Platelet-derived growth factor receptor alpha", "gene_name": "Pdgfra", "organism": "Rat", "refseq_name": "platelet-derived growth factor receptor alpha precursor", "refseq_ac": [ { "id": "NP_036934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036934", "type": "external" } ], "gene_names_uniprotkb": "Pdgfra", "gene_names_refseq": "APDGFR; PDGFACE; Pdgfra", "protein_names_uniprotkb": "Platelet-derived growth factor receptor alpha; 2.7.10.1; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; PDGF-R-alpha; PDGFR-alpha; Platelet-derived growth factor alpha receptor", "protein_names_refseq": "CD140 antigen-like family member A; PDGF-R-alpha; PDGFR-alpha; alpha platelet-derived growth factor receptor; alpha-type platelet-derived growth factor receptor; platelet derived growth factor receptor, alpha polypeptide; platelet-derived growth factor alpha receptor; platelet-derived growth factor receptor alpha precursor; platelet-derived growth factor receptor alpha-like", "tax_id": 10116, "disease": "medulloblastoma (Disease Ontology:DOID:0050902); stroke (Disease Ontology:DOID:0051061); neurodevelopmental disorder with hypotonia and speech delay (Disease Ontology:DOID:0070512); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); oligohydramnios (Disease Ontology:DOID:12215); leukemia (Disease Ontology:DOID:1240); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); prostate adenocarcinoma (Disease Ontology:DOID:2526); Leydig cell tumor (Disease Ontology:DOID:2696); carcinoma (Disease Ontology:DOID:305); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); craniopharyngioma (Disease Ontology:DOID:3840); brain stem glioma (Disease Ontology:DOID:4202); scimitar syndrome (Disease Ontology:DOID:4297); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); nephrolithiasis (Disease Ontology:DOID:585); chronic ulcer of skin (Disease Ontology:DOID:8549); myeloid sarcoma (Disease Ontology:DOID:8683); myeloid leukemia (Disease Ontology:DOID:8692); in situ carcinoma (Disease Ontology:DOID:8719); hypereosinophilic syndrome (Disease Ontology:DOID:999)", "pathway": " (rno:25267); (R-RNO-1257604); (R-RNO-186763); (R-RNO-186797); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "2157969;28245285;29174980;30180991;38843836;8318539", "class_list": "", "function": "CSN6 mediates PDGF-induced pulmonary arterial smooth muscle cells proliferation., [RefSeq, PubMed]; STAT3 overexpression in corpus cavernosum smooth muscle in rats weakened the suppressive effect of PDGFR inhibition on the morphology and phenotypic transformation induced by PDGF-BB Publication Status: Online-Only, [RefSeq, PubMed]; Treatment with different concentrations of PDGF increased the levels of phosphorylated protein kinase B (AKT), beta-catenin, and Cx43, whereas inhibition of PDGFR or activation of phosphatidylinositol 3 kinase (PI3K)/AKT signaling altered b-catenin and Cx43 expression., [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 28, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0001701 in utero embryonic development;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P20786-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7W1-1", "uniprot_id": [ { "id": "PDCD6_RAT", "url": "https://www.uniprot.org/uniprot/G3V7W1", "type": "external" } ], "mass": 21905.0, "length": 191, "protein_name": "Programmed cell death protein 6", "gene_name": "Pdcd6", "organism": "Rat", "refseq_name": "programmed cell death protein 6", "refseq_ac": [ { "id": "NP_001100922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100922", "type": "external" } ], "gene_names_uniprotkb": "Pdcd6; Alg2", "gene_names_refseq": "ALG-2; Pdcd6", "protein_names_uniprotkb": "Programmed cell death protein 6; ALG-2; Apoptosis-linked gene 2 protein homolog", "protein_names_refseq": "apoptosis-linked gene 2 protein homolog; programmed cell death protein 6", "tax_id": 10116, "disease": "", "pathway": " (rno:308061)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27276012;34762908", "class_list": "", "function": "ALG-2 and peflin regulate COPII targeting and secretion in response to calcium signaling., [RefSeq, PubMed]; Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair (By similarity). Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (By similarity). Involved in ER-Golgi transport (PubMed:27276012). Regulates ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (By similarity). Together with PEF1, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (By similarity). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (By similarity). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (By similarity). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (By similarity). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (By similarity). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Has a lower Ca(2+) affinity than isoform 1 (By similarity)., [UniProtKB, UniProtKB]; Has a lower Ca(2+) affinity than isoform 1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5DEP1", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0014029 neural crest formation;GO:0001525 angiogenesis;GO:0006886 intracellular protein transport;GO:0043065 positive regulation of apoptotic process;GO:0051592 response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3V7W1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJP9-1", "uniprot_id": [ { "id": "PHYD1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJP9", "type": "external" } ], "mass": 32553.0, "length": 291, "protein_name": "Phytanoyl-CoA dioxygenase domain-containing protein 1", "gene_name": "Phyhd1", "organism": "Rat", "refseq_name": "phytanoyl-CoA dioxygenase domain-containing protein 1", "refseq_ac": [ { "id": "NP_001013099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013099", "type": "external" } ], "gene_names_uniprotkb": "Phyhd1", "gene_names_refseq": "Phyhd1", "protein_names_uniprotkb": "Phytanoyl-CoA dioxygenase domain-containing protein 1; 1.14.11.-; Protein PHYHD1", "protein_names_refseq": "phytanoyl-CoA dioxygenase domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:296621)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the conversion of 2-oxoglutarate to succinate and CO(2) in an iron-dependent manner. However, does not couple 2OG turnover to the hydroxylation of acyl-coenzyme A derivatives, implying that it is not directly involved in phytanoyl coenzyme-A metabolism. Does not show detectable activity towards fatty acid CoA thioesters., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJP9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C548-1", "uniprot_id": [ { "id": "PLPL2_RAT", "url": "https://www.uniprot.org/uniprot/P0C548", "type": "external" } ], "mass": 52567.0, "length": 478, "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "Pnpla2", "organism": "Rat", "refseq_name": "patatin-like phospholipase domain-containing protein 2", "refseq_ac": [ { "id": "NP_001101979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001101979", "type": "external" } ], "gene_names_uniprotkb": "Pnpla2; Atgl", "gene_names_refseq": "Pnpla2; RGD1309044", "protein_names_uniprotkb": "Patatin-like phospholipase domain-containing protein 2; 3.1.1.3; 3.1.1.4; Adipose triglyceride lipase; Calcium-independent phospholipase A2-zeta; iPLA2-zeta", "protein_names_refseq": "adipose triglyceride lipase; calcium-independent phospholipase A2-zeta; iPLA2-zeta; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain-containing protein 2-like; patatin-like phospholipase domain-containing protein 2", "tax_id": 10116, "disease": "Chanarin-Dorfman syndrome (Disease Ontology:DOID:0050729); acquired metabolic disease (Disease Ontology:DOID:0060158); diabetes mellitus (Disease Ontology:DOID:9351); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:361676); (R-RNO-1482883); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "16906479;19389712;22673903;23408028;24303154;26277390;26511521;27179362;27590244;29393594", "class_list": "", "function": "Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (By similarity). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (By similarity). Regulates adiposome size and may be involved in the degradation of adiposomes (By similarity). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (By similarity). Acts antagonistically with LDAH in regulation of cellular lipid stores (By similarity). Inhibits LDAH-stimulated lipid droplet fusion (By similarity). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Report increased levels of ATGL and its inhibitor G0S2 following endurance training in metabolically different rat skeletal muscles., [RefSeq, PubMed]; TAG synthesis and levels of PUFA-TAGs were lowered by the diacylglycerol acyltransferase (DGAT)1 inhibitor, T863. The lipase inhibitor, Atglistatin, increased the levels of TAG in both WT and ATGL-deficient mouse Hepatic stellate cell (HSC). Both Atglistatin and T863 inhibited the induction of activation marker, alpha-smooth muscle actin, in rat HSCs, but not in mouse HSCs., [RefSeq, PubMed]; To assess its role in insulin secretion, ATGL expression was decreased in INS832/13 cells (ATGL-knockdown (KD)) by small hairpin RNA. ATGL-KD increased the esterification of free fatty acids into triglycerides., [RefSeq, PubMed]; Upregulation of Pnpla2 expression and activation of ATGL (due to an increase in ABHD5 and decrease in G0S2 levels), as well as a coordinated interplay of these genes with Lipe in mesenteric WAT, contribute, at least in part, to an increase in the concentration of circulating NEFA in rats with reduced fat mass., [RefSeq, PubMed]; We conclude that PEDF-R mediates PEDF attenuates hypoxia-induced apoptosis and necrosis in H9c2 cells by inhibiting p53 mitochondrial translocation. Erratum:[Biochem Biophys Res Commun. 2023 Dec 31;689:149159. doi: 10.1016/j.bbrc.2023.149159. PMID: 37985352], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0004806 triacylglycerol lipase activity;GO:0016411 acylglycerol O-acyltransferase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0051264 mono-olein transacylation activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0010891 negative regulation of triglyceride storage;GO:0010898 positive regulation of triglyceride catabolic process;GO:0055088 lipid homeostasis;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P0C548-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q561R3-1", "uniprot_id": [ { "id": "RBM48_RAT", "url": "https://www.uniprot.org/uniprot/Q561R3", "type": "external" } ], "mass": 41863.0, "length": 371, "protein_name": "RNA-binding protein 48", "gene_name": "Rbm48", "organism": "Rat", "refseq_name": "RNA-binding protein 48", "refseq_ac": [ { "id": "NP_001019417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019417", "type": "external" } ], "gene_names_uniprotkb": "Rbm48", "gene_names_refseq": "RGD1310794; Rbm48", "protein_names_uniprotkb": "RNA-binding protein 48", "protein_names_refseq": "RNA-binding protein 48; UPF0712 protein C7orf64 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:296840)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0071018 U12-type catalytic step 2 spliceosome;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q561R3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62755-1", "uniprot_id": [ { "id": "RS6_RAT", "url": "https://www.uniprot.org/uniprot/P62755", "type": "external" } ], "mass": 28681.0, "length": 249, "protein_name": "Small ribosomal subunit protein eS6", "gene_name": "Rps6", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS6", "refseq_ac": [ { "id": "NP_058856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058856", "type": "external" } ], "gene_names_uniprotkb": "Rps6", "gene_names_refseq": "Rps6", "protein_names_uniprotkb": "Small ribosomal subunit protein eS6; 40S ribosomal protein S6", "protein_names_refseq": "40S ribosomal protein S6-like; 40S ribosomal protein S6; small ribosomal subunit protein eS6", "tax_id": 10116, "disease": "autosomal recessive cutis laxa type IA (Disease Ontology:DOID:0070135); autosomal dominant cutis laxa 2 (Disease Ontology:DOID:0070136); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); age related macular degeneration (Disease Ontology:DOID:10871); transient cerebral ischemia (Disease Ontology:DOID:224); cutis laxa (Disease Ontology:DOID:3144); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (rno:29304); (R-RNO-156827); (R-RNO-166208); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-9629569); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 15, "publication_count": 17, "publication_id_list": "17957382;19154606;20110682;2106518;22160257;22673903;25706655;26423232;27194793;28729395;29293066;31112404;31157869;32612497;3277962;38843836;398910", "class_list": "", "function": "A specific deletion of mTOR in Sertoli cells was found to cause an upregulation of p-rpS6-S240/S244 (i.e., an activation of rpS6), but not total rpS6, and was associated with BTB disruption, epithelial damage, loss of cell polarity, and infertility., [RefSeq, PubMed]; Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Overexpression of this rpS6 was capable of inducing blood-testis barrier remodeling, making the barrier 'leaky.', [RefSeq, PubMed]; Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains. results constrain hypotheses about the possible role of rpS6 phosphorylation in regulating postsynaptic protein synthesis during induction of synaptic plasticity. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08227;P10660", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019901 protein kinase binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1903347 negative regulation of bicellular tight junction assembly;GO:0000278 mitotic cell cycle;GO:0008284 positive regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P62755-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13085-1", "uniprot_id": [ { "id": "PTHR_RAT", "url": "https://www.uniprot.org/uniprot/P13085", "type": "external" } ], "mass": 20204.0, "length": 177, "protein_name": "Parathyroid hormone-related protein", "gene_name": "Pthlh", "organism": "Rat", "refseq_name": "parathyroid hormone-related protein preproprotein", "refseq_ac": [ { "id": "NP_036768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036768", "type": "external" } ], "gene_names_uniprotkb": "Pthlh; Pthrp", "gene_names_refseq": "PLP; Pthlh", "protein_names_uniprotkb": "Parathyroid hormone-related protein; PLP; PTH-rP; PTHrP; Parathyroid hormone-like protein", "protein_names_refseq": "PTH-rP; PTHrP; parathyroid hormone-like peptide; parathyroid hormone-like protein; parathyroid hormone-related protein preproprotein; parathyroid hormone-related protein; parathyroid-like peptide", "tax_id": 10116, "disease": "pseudohypoparathyroidism type 1A (Disease Ontology:DOID:0080053); brachydactyly type E2 (Disease Ontology:DOID:0110976); achondroplasia (Disease Ontology:DOID:4480)", "pathway": " (rno:24695); (R-RNO-373080)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "2342478;26538570;2747658;30504697;31311343;31471966;3175653", "class_list": "", "function": "Mutational analyses including insertion of a glycosylation site for the tagged PTHrP revealed that the evolutionarily conserved regions in the signal peptide and the pro-region facilitate the redirection of ppPTHrP from the secretory pathway to the nuclear targeting pathway., [RefSeq, PubMed]; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; PTHLH-mediated PTH1R-PKC theta; pathway activation is a key event in the profibrotic Hh-dependent activation of HSCs, [RefSeq, PubMed]; PTHrP (1-40) stimulates calcium uptake via PTHR1 receptor and PKC alpha/beta signaling pathway in rat enterocytes, and calcium transporters TRPV6 and CaBP-D9k are necessary for this stimulatory effect., [RefSeq, PubMed]; Potent inhibitor of osteoclastic bone resorption., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results indicate that the well-conserved region in the signal peptide plays an essential role in the dual localization of PTHrP through ER targeting and/or the membrane translocation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005576 extracellular region", "go_biological_process": "GO:0060649 mammary gland bud elongation;GO:0060659 nipple sheath formation;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P13085-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498E0-1", "uniprot_id": [ { "id": "TXD12_RAT", "url": "https://www.uniprot.org/uniprot/Q498E0", "type": "external" } ], "mass": 19019.0, "length": 170, "protein_name": "Thioredoxin domain-containing protein 12", "gene_name": "Txndc12", "organism": "Rat", "refseq_name": "thioredoxin domain-containing protein 12 precursor", "refseq_ac": [ { "id": "NP_001094310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094310", "type": "external" } ], "gene_names_uniprotkb": "Txndc12", "gene_names_refseq": "RGD1305960; Txndc12", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 12; 1.8.4.2", "protein_names_refseq": "thioredoxin domain containing 12 (endoplasmic reticulum); thioredoxin domain-containing protein 12 precursor; thioredoxin domain-containing protein 12", "tax_id": 10116, "disease": "", "pathway": " (rno:298370)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12930873;18628206", "class_list": "", "function": "ERp16 mediates disulfide bond formation in the ER and plays an important role in cellular defense against prolonged ER stress, [RefSeq, PubMed]; Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.2", "type": "external" }, { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" } ], "go_molecular_function": "GO:0019153 protein-disulfide reductase (glutathione) activity;GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q498E0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35094-1", "uniprot_id": [ { "id": "TIM44_RAT", "url": "https://www.uniprot.org/uniprot/O35094", "type": "external" } ], "mass": 51060.0, "length": 453, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM44", "gene_name": "Timm44", "organism": "Rat", "refseq_name": "mitochondrial import inner membrane translocase subunit TIM44", "refseq_ac": [ { "id": "NP_058963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058963", "type": "external" } ], "gene_names_uniprotkb": "Timm44; Mimt44; Tim44", "gene_names_refseq": "Timm44", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM44", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit TIM44; translocator of inner mitochondrial membrane 44", "tax_id": 10116, "disease": "proliferative diabetic retinopathy (Disease Ontology:DOID:13207); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (rno:29635)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16641100;9538267", "class_list": "", "function": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0055007 cardiac muscle cell differentiation;GO:0030150 protein import into mitochondrial matrix;GO:1905242 response to 3,3',5-triiodo-L-thyronine", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35094-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q496Z9-1", "uniprot_id": [ { "id": "TRM1L_RAT", "url": "https://www.uniprot.org/uniprot/Q496Z9", "type": "external" } ], "mass": 80184.0, "length": 723, "protein_name": "tRNA (guanine(27)-N(2))-dimethyltransferase", "gene_name": "Trmt1l", "organism": "Rat", "refseq_name": "tRNA (guanine(27)-N(2))-dimethyltransferase", "refseq_ac": [ { "id": "NP_001032269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032269", "type": "external" } ], "gene_names_uniprotkb": "Trmt1l", "gene_names_refseq": "RGD1307890; Trm1l; Trmt1l", "protein_names_uniprotkb": "tRNA (guanine(27)-N(2))-dimethyltransferase; 2.1.1.-; TRMT1-like protein; tRNA methyltransferase 1-like protein", "protein_names_refseq": "TRM1 tRNA methyltransferase 1-like; TRM1-like protein; TRMT1-like protein; tRNA (guanine(27)-N(2))-dimethyltransferase; tRNA methyltransferase 1 homolog-like; tRNA methyltransferase 1-like protein", "tax_id": 10116, "disease": "", "pathway": " (rno:304851)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups. Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons. Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016423 tRNA (guanine) methyltransferase activity;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0160248 tRNA (guanine(27)-N2)-dimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0002940 tRNA N2-guanine methylation;GO:0008033 tRNA processing;GO:0008344 adult locomotory behavior;GO:0030534 adult behavior;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q496Z9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30121-1", "uniprot_id": [ { "id": "TIMP2_RAT", "url": "https://www.uniprot.org/uniprot/P30121", "type": "external" } ], "mass": 24356.0, "length": 220, "protein_name": "Metalloproteinase inhibitor 2", "gene_name": "Cep295nl; Timp2", "organism": "Rat", "refseq_name": "metalloproteinase inhibitor 2 precursor", "refseq_ac": [ { "id": "NP_068824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068824", "type": "external" } ], "gene_names_uniprotkb": "Cep295nl; Timp2; Timp-2", "gene_names_refseq": "Timp2", "protein_names_uniprotkb": "Metalloproteinase inhibitor 2; TIMP-2; Tissue inhibitor of metalloproteinases 2", "protein_names_refseq": "TIMP-2; metalloproteinase inhibitor 2 precursor; metalloproteinase inhibitor 2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); intracranial aneurysm (Disease Ontology:DOID:10941); urinary bladder cancer (Disease Ontology:DOID:11054); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Huntington's disease (Disease Ontology:DOID:12858); Moyamoya disease (Disease Ontology:DOID:13099); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Marfan syndrome (Disease Ontology:DOID:14323); preretinal fibrosis (Disease Ontology:DOID:2006); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:29543); (rno:498028); (R-RNO-1592389); (R-RNO-6798695); (R-RNO-9839383)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "11684074;1309971;22673903;29302675;29308554;29955613;31392726;34830409;8050496;8203893;8792217", "class_list": "", "function": "Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor., [UniProtKB, UniProtKB, UniProtKB]; Dynamics of distribution of capillaries with MMP2 and TIMP2 expressed in rat brain during development of experimental hypertension has been reported., [RefSeq, PubMed]; Exogenous TIMP-2 interfered with local MMP-2 expression, delaying peak expression of MMP-2 and slowing the scarring of filtering blebs during wound healing of subconjunctival tissue. Publication Status: Online-Only, [RefSeq, PubMed]; High TIMP2 expression is associated with myocardial fibrosis in cardiac hypertrophy., [RefSeq, PubMed]; Long noncoding RNA MEG3 silencing protects against hypoxia-induced pheochromocytoma-12 cell injury through inhibition of TIMP2 promoter methylation., [RefSeq, PubMed]; Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF Expression and Immunolocalization in Bone and Cartilage in Newborn Offspring Prenatally Exposed to Fumonisins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q546J4", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030426 growth cone;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0046580 negative regulation of Ras protein signal transduction;GO:0032487 regulation of Rap protein signal transduction;GO:1905049 negative regulation of metallopeptidase activity;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P30121-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97613-1", "uniprot_id": [ { "id": "PTTG1_RAT", "url": "https://www.uniprot.org/uniprot/P97613", "type": "external" } ], "mass": 21571.0, "length": 199, "protein_name": "Securin", "gene_name": "Pttg1", "organism": "Rat", "refseq_name": "securin", "refseq_ac": [ { "id": "NP_071786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071786", "type": "external" } ], "gene_names_uniprotkb": "Pttg1; Pttg", "gene_names_refseq": "Pttg1; Pttg", "protein_names_uniprotkb": "Securin; Pituitary tumor-transforming gene 1 protein", "protein_names_refseq": "Pituitary tumor transforming; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1 protein; securin", "tax_id": 10116, "disease": "", "pathway": " (rno:64193); (R-RNO-174154); (R-RNO-174178); (R-RNO-2467813)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "19800905;22673903;25023895;27250217;35050550;37018988;9092795;9478977;9915854", "class_list": "", "function": "Altered Cx43 expression modulates Pituitary tumor transforming gene expression, which correlates with prolactinoma development., [RefSeq, PubMed]; EAP1 (Pttg1) gene may be involved in the neuroendocrine control of female puberty in correlation with the kisspeptin signaling., [RefSeq, PubMed]; PTTG1 promotes CD34[+]CD45[+] cells to repair the pulmonary vascular barrier via activating the VEGF-bFGF/PI3K/AKT/eNOS signaling pathway in rats with phosgene-induced acute lung injury., [RefSeq, PubMed]; Pttg1 could predict inter-individual susceptibility to D-galactosamine induced hepatotoxicity, [RefSeq, PubMed]; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity)., [UniProtKB]; The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0031072 heat shock protein binding;GO:0043022 ribosome binding;GO:0004869 cysteine-type endopeptidase inhibitor activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0005930 axoneme", "go_biological_process": "GO:0045143 homologous chromosome segregation;GO:0006281 DNA repair;GO:0007059 chromosome segregation;GO:0008285 negative regulation of cell population proliferation;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P97613-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05712-1", "uniprot_id": [ { "id": "RAB2A_RAT", "url": "https://www.uniprot.org/uniprot/P05712", "type": "external" } ], "mass": 23536.0, "length": 212, "protein_name": "Ras-related protein Rab-2A", "gene_name": "Rab2a", "organism": "Rat", "refseq_name": "ras-related protein Rab-2A", "refseq_ac": [ { "id": "NP_113906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113906", "type": "external" } ], "gene_names_uniprotkb": "Rab2a; Rab2", "gene_names_refseq": "Rab2a; Rab2", "protein_names_uniprotkb": "Ras-related protein Rab-2A; 3.6.5.2", "protein_names_refseq": "RAB2, member RAS oncogene family; ras-related protein Rab-2A", "tax_id": 10116, "disease": "", "pathway": " (rno:65158); (R-RNO-162658); (R-RNO-8873719)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "3317403", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi. Together with RAB2B, redundantly required for efficient autophagic flux., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0043025 neuronal cell body", "go_biological_process": "GO:0015031 protein transport;GO:0016236 macroautophagy;GO:0016192 vesicle-mediated transport;GO:0007030 Golgi organization;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P05712-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40112-1", "uniprot_id": [ { "id": "PSB3_RAT", "url": "https://www.uniprot.org/uniprot/P40112", "type": "external" } ], "mass": 22965.0, "length": 205, "protein_name": "Proteasome subunit beta type-3", "gene_name": "Psmb3", "organism": "Rat", "refseq_name": "proteasome subunit beta type-3", "refseq_ac": [ { "id": "NP_058981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058981", "type": "external" } ], "gene_names_uniprotkb": "Psmb3", "gene_names_refseq": "Psmb3", "protein_names_uniprotkb": "Proteasome subunit beta type-3; Proteasome chain 13; Proteasome component C10-II; Proteasome subunit beta-3; Proteasome theta chain; beta-3", "protein_names_refseq": "beta-3; proteasome (prosome, macropain) subunit, beta type 3; proteasome beta 3 subunit; proteasome chain 13; proteasome component C10-II; proteasome subunit beta 3; proteasome subunit beta type-3; proteasome theta chain", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:29676); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 58, "publication_count": 1, "publication_id_list": "8282111", "class_list": "", "function": "Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB, UniProtKB]; Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P40112-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MA98-1", "uniprot_id": [ { "id": "TPR_RAT", "url": "https://www.uniprot.org/uniprot/F1MA98", "type": "external" } ], "mass": 267306.0, "length": 2360, "protein_name": "Nucleoprotein TPR", "gene_name": "Tpr", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tpr", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleoprotein TPR; Megator; NPC-associated intranuclear protein; Translocated promoter region protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (rno:304862); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885)", "pathway_count": 18, "publication_count": 2, "publication_id_list": "11839768;22673903", "class_list": "", "function": "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases (By similarity). Plays a role in the regulation of nuclear protein export., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q3T1J7", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0042803 protein homodimerization activity;GO:0031072 heat shock protein binding;GO:0051019 mitogen-activated protein kinase binding", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0046832 negative regulation of RNA export from nucleus;GO:0035457 cellular response to interferon-alpha;GO:0006999 nuclear pore organization;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1MA98-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06302-1", "uniprot_id": [ { "id": "PTMA_RAT", "url": "https://www.uniprot.org/uniprot/P06302", "type": "external" } ], "mass": 12382.0, "length": 112, "protein_name": "Prothymosin alpha", "gene_name": "Ptmal3; Ptma", "organism": "Rat", "refseq_name": "prothymosin alpha", "refseq_ac": [ { "id": "NP_068508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068508", "type": "external" } ], "gene_names_uniprotkb": "Ptmal3; Ptma; LOC689166; Ptmal5", "gene_names_refseq": "Ptma", "protein_names_uniprotkb": "Prothymosin alpha", "protein_names_refseq": "alpha-prothymosin; prothymosin alpha", "tax_id": 10116, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:29222); (rno:689166)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "1989881;20432433;20467443;22673903;2269362;23278181;23359453;3377505;3855555", "class_list": "", "function": "PTMA is specifically localized in the acrosome of epididymal sperm, [RefSeq, PubMed]; PTMA specific localization in the heads of spermatids and epididymal spermatozoa, associated with the acrosome system, supports for the first time the hypothesis of a direct function in male germ cells., [RefSeq, PubMed]; Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results suggest necrosis-inducing stress induces an extacellular release of prothymosin-alpha in a non-vesicular manner; apoptosis-inducing stress does not, owing to loss of its interaction with S100A13, a cargo molecule for extracellular release, [RefSeq, PubMed]; The active core peptide sequence P30 (amino acids 49-78) of prothymosin alpha exerts its full survival effect in cultured cortical neurons against ischemic stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q569C8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0042393 histone binding;GO:0140297 DNA-binding transcription factor binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P06302-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJL5-1", "uniprot_id": [ { "id": "SBNO1_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJL5", "type": "external" } ], "mass": 140741.0, "length": 1269, "protein_name": "Protein strawberry notch homolog 1", "gene_name": "Sbno1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sbno1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein strawberry notch homolog 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:304470)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays a crucial role in the regulation of neural stem cells (NSCs) proliferation. Enhances the phosphorylation of GSK3B through the PI3K-Akt signaling pathway, thereby upregulating the Wnt/beta-catenin signaling pathway and promoting the proliferation of NSCs. Improves ischemic stroke recovery while inhibiting neuroinflammation through small extracellular vesicles (sEVs)-mediated mechanism. Enhances the secretion of sEVs from NSCs, which in turn inhibit both the MAPK and NF-kappaB pathways in microglia. This inhibition suppresses the pro-inflammatory M1 polarization of microglia, promoting a shift towards the M2 anti-inflammatory phenotype, which is beneficial for reducing neuroinflammation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031490 chromatin DNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006954 inflammatory response;GO:0006355 regulation of DNA-templated transcription;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJL5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54975-1", "uniprot_id": [ { "id": "XPP1_RAT", "url": "https://www.uniprot.org/uniprot/O54975", "type": "external" } ], "mass": 69658.0, "length": 623, "protein_name": "Xaa-Pro aminopeptidase 1", "gene_name": "Xpnpep1", "organism": "Rat", "refseq_name": "xaa-Pro aminopeptidase 1 isoform 2", "refseq_ac": [ { "id": "NP_571988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571988", "type": "external" } ], "gene_names_uniprotkb": "Xpnpep1; App", "gene_names_refseq": "Xpnpep1", "protein_names_uniprotkb": "Xaa-Pro aminopeptidase 1; 3.4.11.9; Aminoacylproline aminopeptidase; Cytosolic aminopeptidase P; Soluble aminopeptidase P; X-Pro aminopeptidase 1; X-prolyl aminopeptidase 1, soluble; sAmp", "protein_names_refseq": "X-Pro aminopeptidase 1, soluble; X-prolyl aminopeptidase (aminopeptidase P) 1, soluble; X-prolyl aminopeptidase 1, soluble; aminoacylproline aminopeptidase; cytoplasmic aminopeptidase P; cytosolic aminopeptidase P; sAmp; soluble aminopeptidase P; xaa-Pro aminopeptidase 1 isoform 2; xaa-Pro aminopeptidase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:170751)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10095056;12874451;17515839;20431301;26683993", "class_list": "", "function": "Aminopeptidase P expressed in endothelial caveolae appears to be readily accessible to circulating antibody rather specifically in lung., [RefSeq, PubMed]; Aminopeptidase P expression is higher in the cerebral arteries of Fawn Hooded Hypertensive rats compared to Brown Norway rats. Publication Status: Online-Only, [RefSeq, PubMed]; Aminopeptidase p and podoplanin are expressed in endothelial cells of blood and lymphatic vessels Erratum:[J Am Soc Nephrol. 2003 Oct;14(10):following table of contents. Kang Due-Hee [corrected to Kang Duk-Hee]], [RefSeq, PubMed]; Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:10095056). Contributes to the degradation of bradykinin (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results describe the organ distribution, developmental change and specific inhibitors of prolidases I and II in the rat., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0043069 negative regulation of programmed cell death;GO:0010815 bradykinin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O54975-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70280-1", "uniprot_id": [ { "id": "WFDC1_RAT", "url": "https://www.uniprot.org/uniprot/O70280", "type": "external" } ], "mass": 23230.0, "length": 212, "protein_name": "WAP four-disulfide core domain protein 1", "gene_name": "Wfdc1", "organism": "Rat", "refseq_name": "WAP four-disulfide core domain protein 1 precursor", "refseq_ac": [ { "id": "NP_598265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598265", "type": "external" } ], "gene_names_uniprotkb": "Wfdc1; Ps20", "gene_names_refseq": "Wfdc1; ps20", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 1; Prostate stromal protein ps20; ps20 growth inhibitor", "protein_names_refseq": "20-kDa prostate stromal protein; WAP four-disulfide core domain protein 1 precursor; WAP four-disulfide core domain protein 1; prostate stromal protein ps20; ps20 growth inhibitor", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:171112)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15677758;7665628;9468514", "class_list": "", "function": "Data indicate that ps20 protein uterine expression is negatively regulated by estrogens and tamoxifen and suggest that ps20 may function as a mediator of local growth, [RefSeq, PubMed]; Has growth inhibitory activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0050680 negative regulation of epithelial cell proliferation;GO:0050728 negative regulation of inflammatory response;GO:0001558 regulation of cell growth;GO:0032355 response to estradiol;GO:0061045 negative regulation of wound healing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O70280-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5X8-1", "uniprot_id": [ { "id": "TTYH1_RAT", "url": "https://www.uniprot.org/uniprot/P0C5X8", "type": "external" } ], "mass": 49032.0, "length": 450, "protein_name": "Protein tweety homolog 1", "gene_name": "Ttyh1", "organism": "Rat", "refseq_name": "protein tweety homolog 1 isoform 1", "refseq_ac": [ { "id": "NP_001099695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099695", "type": "external" } ], "gene_names_uniprotkb": "Ttyh1", "gene_names_refseq": "Ttyh1", "protein_names_uniprotkb": "Protein tweety homolog 1; Volume-regulated anion channel subunit Ttyh1", "protein_names_refseq": "protein tweety homolog 1 isoform 1; protein tweety homolog 1; volume-regulated anion channel subunit Ttyh1", "tax_id": 10116, "disease": "", "pathway": " (rno:292597); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17116230;22673903", "class_list": "", "function": "Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Probable chloride channel., [UniProtKB, UniProtKB, UniProtKB]; These data suggest a role for Ttyh1 in process formation, cell adhesion and possibly as a transmembrane receptor., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0005509 calcium ion binding;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0030868 smooth endoplasmic reticulum membrane;GO:0031527 filopodium membrane", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007219 Notch signaling pathway;GO:0046847 filopodium assembly;GO:0048863 stem cell differentiation;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C5X8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00438-1", "uniprot_id": [ { "id": "PTBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q00438", "type": "external" } ], "mass": 59366.0, "length": 556, "protein_name": "Polypyrimidine tract-binding protein 1", "gene_name": "Ptbp1", "organism": "Rat", "refseq_name": "polypyrimidine tract-binding protein 1 isoform a", "refseq_ac": [ { "id": "NP_001257986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257986", "type": "external" } ], "gene_names_uniprotkb": "Ptbp1; Ptb; Pybp; Tbfii", "gene_names_refseq": "PTB1; Ptbp1; Ptb; Pybp1; Pybp2; Pybp", "protein_names_uniprotkb": "Polypyrimidine tract-binding protein 1; Heterogeneous nuclear ribonucleoprotein I; PTB; PYBP; Pyrimidine-binding protein; hnRNP I", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein I; hnRNP I; polypyrimidine tract-binding protein 1 isoform a; pyrimidine binding protein 1; pyrimidine binding protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:29497); (R-RNO-6803529); (R-RNO-72163); (R-RNO-72203); (R-RNO-9770562)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "11911361;1681508;34012255;34502162;35997022;38563050", "class_list": "", "function": "Inhibition of IGF2BP1 attenuates the progression of endometriosis through PTBP1., [RefSeq, PubMed]; PTBP1 Targets ILK to Regulate the Hypoxia-Induced Phenotypic Transformation of Pulmonary Artery Smooth Muscle Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RRM RNA-binding domain role in RNA splicing, [RefSeq, PubMed]; Reduced CircSMOC1 Level Promotes Metabolic Reprogramming via PTBP1 (Polypyrimidine Tract-Binding Protein) and miR-329-3p in Pulmonary Arterial Hypertension Rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LM18;Q63568;Q6P736", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0001069 regulatory region RNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0044306 neuron projection terminus", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0003231 cardiac ventricle development;GO:0006397 mRNA processing;GO:0010976 positive regulation of neuron projection development;GO:0032024 positive regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q00438-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C1G7-1", "uniprot_id": [ { "id": "WBP1L_RAT", "url": "https://www.uniprot.org/uniprot/P0C1G7", "type": "external" } ], "mass": 37984.0, "length": 344, "protein_name": "WW domain binding protein 1-like", "gene_name": "Wbp1l", "organism": "Rat", "refseq_name": "WW domain binding protein 1-like isoform X1", "refseq_ac": [ { "id": "XP_006231570", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006231570", "type": "external" } ], "gene_names_uniprotkb": "Wbp1l; Opal1", "gene_names_refseq": "Opal1; RGD1305793; Wbp1l", "protein_names_uniprotkb": "WW domain binding protein 1-like; Outcome predictor in acute leukemia 1 homolog", "protein_names_refseq": "WW domain binding protein 1-like isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:309456)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0030097 hemopoiesis;GO:0031398 positive regulation of protein ubiquitination;GO:0038160 CXCL12-activated CXCR4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C1G7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49952-1", "uniprot_id": [ { "id": "WT1_RAT", "url": "https://www.uniprot.org/uniprot/P49952", "type": "external" } ], "mass": 49193.0, "length": 448, "protein_name": "Wilms tumor protein homolog", "gene_name": "Wt1", "organism": "Rat", "refseq_name": "Wilms tumor protein homolog", "refseq_ac": [ { "id": "NP_113722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113722", "type": "external" } ], "gene_names_uniprotkb": "Wt1; Wt-1", "gene_names_refseq": "Wt1", "protein_names_uniprotkb": "Wilms tumor protein homolog", "protein_names_refseq": "Wilms tumor 1; Wilms tumor protein homolog", "tax_id": 10116, "disease": "Frasier syndrome (Disease Ontology:DOID:0050438); ovarian serous carcinoma (Disease Ontology:DOID:0050933); nephrotic syndrome type 4 (Disease Ontology:DOID:0080383); glutamate formiminotransferase deficiency (Disease Ontology:DOID:0111679); Alzheimer's disease (Disease Ontology:DOID:10652); lung cancer (Disease Ontology:DOID:1324); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); malignant mesothelioma (Disease Ontology:DOID:1790); nephroblastoma (Disease Ontology:DOID:2154); Denys-Drash syndrome (Disease Ontology:DOID:3764); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); renal Wilms' tumor (Disease Ontology:DOID:5176); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (rno:24883)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1330293;30242881;34554376;38182143;7926762", "class_list": "", "function": "Low WT1 expression is associated with membranous nephropathy., [RefSeq, PubMed]; MicroRNA-193a Promotes Apoptosis in Retinal Neuronal Cells in Early-Stage Diabetic (DM) Rat via Wilms' Tumor Gene 1. Publication Status: Online-Only, [RefSeq, PubMed]; Rno-miR-128-3p promotes apoptosis in rat granulosa cells (GCs) induced by norepinephrine through Wilms tumor 1 (WT1)., [RefSeq, PubMed]; This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the human gene is mutated in a small subset of patients with Wilm's tumors. Authors of PMID:7926762 provide evidence that Wt1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0003156 regulation of animal organ formation;GO:0007530 sex determination;GO:0035802 adrenal cortex formation;GO:2000020 positive regulation of male gonad development;GO:0072302 negative regulation of metanephric glomerular mesangial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P49952-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51650-1", "uniprot_id": [ { "id": "SSDH_RAT", "url": "https://www.uniprot.org/uniprot/P51650", "type": "external" } ], "mass": 56131.0, "length": 523, "protein_name": "Succinate-semialdehyde dehydrogenase, mitochondrial", "gene_name": "Aldh5a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Aldh5a1; Ssadh", "gene_names_refseq": "", "protein_names_uniprotkb": "Succinate-semialdehyde dehydrogenase, mitochondrial; 1.2.1.24; Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenase; SSADH", "protein_names_refseq": "", "tax_id": 10116, "disease": "succinic semialdehyde dehydrogenase deficiency (Disease Ontology:DOID:0060175); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (R-RNO-916853)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7814412", "class_list": "", "function": "Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity;GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0031406 carboxylic acid binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006536 glutamate metabolic process;GO:0007417 central nervous system development;GO:0009791 post-embryonic development;GO:0009448 gamma-aminobutyric acid metabolic process;GO:0006105 succinate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P51650-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q10836-1", "uniprot_id": [ { "id": "TRHDE_RAT", "url": "https://www.uniprot.org/uniprot/Q10836", "type": "external" } ], "mass": 121977.0, "length": 1066, "protein_name": "Thyrotropin-releasing hormone-degrading ectoenzyme", "gene_name": "Trhde", "organism": "Rat", "refseq_name": "thyrotropin-releasing hormone-degrading ectoenzyme", "refseq_ac": [ { "id": "NP_001102461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102461", "type": "external" } ], "gene_names_uniprotkb": "Trhde", "gene_names_refseq": "PAP-II; Trhde", "protein_names_uniprotkb": "Thyrotropin-releasing hormone-degrading ectoenzyme; 3.4.19.6; PAP-II; Pyroglutamyl-peptidase II; TRH-DE; TRH-degrading ectoenzyme; TRH-specific aminopeptidase; Thyroliberinase", "protein_names_refseq": "TRH-DE; TRH-degrading ectoenzyme; TRH-specific aminopeptidase; pyroglutamyl-peptidase II; thyroliberinase; thyrotropin-releasing hormone-degrading ectoenzyme", "tax_id": 10116, "disease": "", "pathway": " (rno:366894)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10785382;16611635;19179432;21329657;22532627;22719053;25942072;7937801", "class_list": "", "function": "An increase in circulating thyroid hormone up-regulates PPII activity in tanycytes and enhances degradation of extracellular TRH in the median eminence through glial-axonal associations., [RefSeq, PubMed]; Delayed increases in both the median eminence PPII as well as the thyroliberinase activities in fasted male rats may facilitate the maintenance of deep downregulation of the HPT axis function, despite a partial reactivation of TRH expression in the PVN., [RefSeq, PubMed]; Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II., [RefSeq, PubMed]; PAP-I and PAP-II expression was induced by the decreased dopamine levels in the intermediate lobe of the pituitary under continuous stress., [RefSeq, PubMed]; Shortening of side chain at PPII-269 position is required for adjustment to thepyroglutamyl residue, [RefSeq, PubMed]; Specific inactivation of TRH after its release., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Twenty to 35% of Pyroglutamyl peptidase II mRNA-labeled profiles were positive for TRH-receptor 1 (TRH-R1) mRNA., [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "G3V6Q2", "ec_number_list": [], "go_molecular_function": "GO:0016920 pyroglutamyl-peptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0008237 metallopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q10836-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16612-1", "uniprot_id": [ { "id": "VEGFA_RAT", "url": "https://www.uniprot.org/uniprot/P16612", "type": "external" } ], "mass": 25239.0, "length": 214, "protein_name": "Vascular endothelial growth factor A", "gene_name": "Vegfa", "organism": "Rat", "refseq_name": "vascular endothelial growth factor A isoform 3", "refseq_ac": [ { "id": "NP_001103804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103804", "type": "external" } ], "gene_names_uniprotkb": "Vegfa; Vegf", "gene_names_refseq": "VEGF-A; VEGF111; VEGF164; VPF; Vegfa; Vegf", "protein_names_uniprotkb": "Vascular endothelial growth factor A; VEGF-A; VPF; Vascular permeability factor", "protein_names_refseq": "vascular endothelial growth factor A isoform 3; vascular permeability factor", "tax_id": 10116, "disease": "pterygium (Disease Ontology:DOID:0002116); erythema multiforme (Disease Ontology:DOID:0050185); inflammatory bowel disease (Disease Ontology:DOID:0050589); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); brain glioma (Disease Ontology:DOID:0060108); ischemic colitis (Disease Ontology:DOID:0060181); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); atrial fibrillation (Disease Ontology:DOID:0060224); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); alcohol-associated liver disease (Disease Ontology:DOID:0070658); COVID-19 (Disease Ontology:DOID:0080600); graft-versus-host disease (Disease Ontology:DOID:0081267); vestibular schwannomatosis (Disease Ontology:DOID:0111252); neurofibromatosis 1 (Disease Ontology:DOID:0111253); prostate cancer (Disease Ontology:DOID:10283); retinitis pigmentosa (Disease Ontology:DOID:10584); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); intracranial aneurysm (Disease Ontology:DOID:10941); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); DiGeorge syndrome (Disease Ontology:DOID:11198); pulmonary edema (Disease Ontology:DOID:11396); polycystic ovary syndrome (Disease Ontology:DOID:11612); diabetic angiopathy (Disease Ontology:DOID:11713); primary biliary cholangitis (Disease Ontology:DOID:12236); Graves' disease (Disease Ontology:DOID:12361); retinal ischemia (Disease Ontology:DOID:12510); acoustic neuroma (Disease Ontology:DOID:12689); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); retinopathy of prematurity (Disease Ontology:DOID:13025); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); Behcet's disease (Disease Ontology:DOID:13241); Kawasaki disease (Disease Ontology:DOID:13378); adhesions of uterus (Disease Ontology:DOID:13812); interstitial cystitis (Disease Ontology:DOID:13949); adult-onset Still's disease (Disease Ontology:DOID:14256); colon carcinoma (Disease Ontology:DOID:1520); acute chest syndrome (Disease Ontology:DOID:1584); congenital heart disease (Disease Ontology:DOID:1682); glaucoma (Disease Ontology:DOID:1686); neovascular glaucoma (Disease Ontology:DOID:1687); duodenal ulcer (Disease Ontology:DOID:1724); retinal vein occlusion (Disease Ontology:DOID:1727); melanoma (Disease Ontology:DOID:1909); autoimmune hepatitis (Disease Ontology:DOID:2048); colon cancer (Disease Ontology:DOID:219); opiate dependence (Disease Ontology:DOID:2559); larynx cancer (Disease Ontology:DOID:2596); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); glomerulonephritis (Disease Ontology:DOID:2921); granulosa cell tumor (Disease Ontology:DOID:2999); allergic contact dermatitis (Disease Ontology:DOID:3042); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); gingivitis (Disease Ontology:DOID:3087); inverted papilloma (Disease Ontology:DOID:3179); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); neurofibrosarcoma (Disease Ontology:DOID:3512); middle cerebral artery infarction (Disease Ontology:DOID:3525); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); seminoma (Disease Ontology:DOID:4440); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); rhinitis (Disease Ontology:DOID:4483); brain edema (Disease Ontology:DOID:4724); liver cirrhosis (Disease Ontology:DOID:5082); renal Wilms' tumor (Disease Ontology:DOID:5176); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); uveal melanoma (Disease Ontology:DOID:6039); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); retinal telangiectasia (Disease Ontology:DOID:7736); extrinsic allergic alveolitis (Disease Ontology:DOID:841); dermatitis herpetiformis (Disease Ontology:DOID:8505); bullous pemphigoid (Disease Ontology:DOID:8506); chronic fatigue syndrome (Disease Ontology:DOID:8544); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); cholesteatoma (Disease Ontology:DOID:869); decubitus ulcer (Disease Ontology:DOID:8717); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); hepatopulmonary syndrome (Disease Ontology:DOID:900); sudden infant death syndrome (Disease Ontology:DOID:9007); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); diabetic neuropathy (Disease Ontology:DOID:9743); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (rno:83785); (R-RNO-114608); (R-RNO-194313); (R-RNO-195399); (R-RNO-4420097); (R-RNO-5218921)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10878616;11163598;2320579;38342180;38593124;38739522;7706320", "class_list": "", "function": "Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; LncRNA XIST promotes neovascularization in diabetic retinopathy by regulating miR-101-3p/VEGFA., [RefSeq, PubMed]; MicroRNA-9a-5p disrupts the ELAVL1/VEGF axis to alleviate traumatic brain injury., [RefSeq, PubMed]; Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1alpha/VEGF signaling pathway: Bioinformatics analysis and experimental validation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 107, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q541S6;Q91ZE1;Q9JKX7;Q9QXG6;Q9QXG7", "ec_number_list": [], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0043183 vascular endothelial growth factor receptor 1 binding;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0019838 growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005912 adherens junction", "go_biological_process": "GO:1901532 regulation of hematopoietic progenitor cell differentiation;GO:1902966 positive regulation of protein localization to early endosome;GO:1903672 positive regulation of sprouting angiogenesis;GO:0097533 cellular stress response to acid chemical;GO:0060319 primitive erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P16612-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53809-1", "uniprot_id": [ { "id": "PPCT_RAT", "url": "https://www.uniprot.org/uniprot/P53809", "type": "external" } ], "mass": 24734.0, "length": 214, "protein_name": "Phosphatidylcholine transfer protein", "gene_name": "Pctp", "organism": "Rat", "refseq_name": "phosphatidylcholine transfer protein isoform 1", "refseq_ac": [ { "id": "NP_058921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058921", "type": "external" } ], "gene_names_uniprotkb": "Pctp; Stard2", "gene_names_refseq": "PC-TP; Pctp; stARD2", "protein_names_uniprotkb": "Phosphatidylcholine transfer protein; PC-TP; START domain-containing protein 2; StAR-related lipid transfer protein 2; StARD2", "protein_names_refseq": "START domain-containing protein 2; phosphatidylcholine transfer protein isoform 1; stAR-related lipid transfer protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:29510); (R-RNO-1483191); (R-RNO-77289)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10415339;8645232", "class_list": "", "function": "Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z2N9", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0031210 phosphatidylcholine binding;GO:0008525 phosphatidylcholine transporter activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0015914 phospholipid transport;GO:0120163 negative regulation of cold-induced thermogenesis;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P53809-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQS8-1", "uniprot_id": [ { "id": "NUP85_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQS8", "type": "external" } ], "mass": 74881.0, "length": 656, "protein_name": "Nuclear pore complex protein Nup85", "gene_name": "Nup85", "organism": "Rat", "refseq_name": "nuclear pore complex protein Nup85", "refseq_ac": [ { "id": "NP_001020572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020572", "type": "external" } ], "gene_names_uniprotkb": "Nup85; Pcnt1", "gene_names_refseq": "Nup85; Pcnt1", "protein_names_uniprotkb": "Nuclear pore complex protein Nup85; 85 kDa nucleoporin; Nucleoporin Nup85; Pericentrin-1", "protein_names_refseq": "85 kDa nucleoporin; nuclear pore complex protein Nup85; nucleoporin 85kDa; nucleoporin NUP85; pericentrin-1", "tax_id": 10116, "disease": "nephrotic syndrome type 17 (Disease Ontology:DOID:0080392)", "pathway": " (rno:287830); (R-RNO-141430); (R-RNO-141444); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9615933); (R-RNO-9648025)", "pathway_count": 26, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. Involved in nephrogenesis., [UniProtKB, UniProtKB]; Functions as a component of the nuclear pore complex (NPC)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0072006 nephron development;GO:0006406 mRNA export from nucleus;GO:0006935 chemotaxis;GO:0045893 positive regulation of DNA-templated transcription;GO:0030032 lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QQS8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01818-1", "uniprot_id": [ { "id": "VMAT1_RAT", "url": "https://www.uniprot.org/uniprot/Q01818", "type": "external" } ], "mass": 55935.0, "length": 521, "protein_name": "Chromaffin granule amine transporter", "gene_name": "Slc18a1", "organism": "Rat", "refseq_name": "chromaffin granule amine transporter", "refseq_ac": [ { "id": "NP_037284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037284", "type": "external" } ], "gene_names_uniprotkb": "Slc18a1; Cgat; Vmat1", "gene_names_refseq": "CGAT; Slc18a1; VMAT-1", "protein_names_uniprotkb": "Chromaffin granule amine transporter; Solute carrier family 18 member 1; VAT1; Vesicular amine transporter 1", "protein_names_refseq": "VAT1; VMAT1; chromaffin granule amine transporter; solute carrier family 18 (vesicular monoamine transporter), member 1; solute carrier family 18 (vesicular monoamine), member 1; solute carrier family 18 member 1; solute carrier family18 (vesicular monoamine) member 1 (chromaffin granule amine transporter); vesicular amine transporter 1; vesicular monoamine transporter 1", "tax_id": 10116, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460); von Hippel-Lindau disease (Disease Ontology:DOID:14175); bipolar disorder (Disease Ontology:DOID:3312); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809)", "pathway": " (rno:25693)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1505023;22253933;31955909;8125935", "class_list": "", "function": "Differences in the expression of catecholamine-synthesizing enzymes between vesicular monoamine transporter 1- and 2-immunoreactive glomus cells in the rat carotid body., [RefSeq, PubMed]; Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin (PubMed:1505023, PubMed:8125935). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Transfection of VMAT-1 and TPH-1 induced vesicular storage of serotonin which is triggered release upon cooling and has protective effects against hypothermia., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0005335 serotonin:sodium:chloride symporter activity;GO:0015311 monoamine:proton antiporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0043195 terminal bouton;GO:0045202 synapse;GO:0005789 endoplasmic reticulum membrane;GO:0030667 secretory granule membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0033603 positive regulation of dopamine secretion;GO:0051612 negative regulation of serotonin uptake;GO:0090494 dopamine uptake;GO:0051610 serotonin uptake;GO:0071285 cellular response to lithium ion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q01818-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61621-1", "uniprot_id": [ { "id": "S61A1_RAT", "url": "https://www.uniprot.org/uniprot/P61621", "type": "external" } ], "mass": 52265.0, "length": 476, "protein_name": "Protein transport protein Sec61 subunit alpha isoform 1", "gene_name": "Sec61a1; Sec61a2", "organism": "Rat", "refseq_name": "protein transport protein Sec61 subunit alpha isoform 1", "refseq_ac": [ { "id": "NP_954865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954865", "type": "external" } ], "gene_names_uniprotkb": "Sec61a1; Sec61a2; Sec61a1; Sec61a", "gene_names_refseq": "Sec61a1; Sec61a", "protein_names_uniprotkb": "Protein transport protein Sec61 subunit alpha isoform 1; Sec61 alpha-1", "protein_names_refseq": "SEC61, alpha subunit; Sec61 alpha 1 subunit; Sec61 alpha subunit homolog; Sec61 translocon alpha 1 subunit; protein transport protein Sec61 subunit alpha isoform 1; protein transport protein Sec61 subunit alpha; sec61 alpha-1", "tax_id": 10116, "disease": "severe congenital neutropenia (Disease Ontology:DOID:0050590); autosomal dominant tubulointerstitial kidney disease 5 (Disease Ontology:DOID:0061120); common variable immunodeficiency (Disease Ontology:DOID:12177)", "pathway": " (rno:361273); (rno:80843)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "1423609", "class_list": "", "function": "Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P38378;P57726;Q505I3", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0022857 transmembrane transporter activity;GO:0005048 signal sequence binding;GO:0043022 ribosome binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005784 Sec61 translocon complex", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0045048 protein insertion into ER membrane;GO:0006613 cotranslational protein targeting to membrane;GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0031204 post-translational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61621-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62282-1", "uniprot_id": [ { "id": "RS11_RAT", "url": "https://www.uniprot.org/uniprot/P62282", "type": "external" } ], "mass": 18431.0, "length": 158, "protein_name": "Small ribosomal subunit protein uS17", "gene_name": "Rps11", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS17", "refseq_ac": [ { "id": "NP_112372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112372", "type": "external" } ], "gene_names_uniprotkb": "Rps11", "gene_names_refseq": "Rps11", "protein_names_uniprotkb": "Small ribosomal subunit protein uS17; 40S ribosomal protein S11", "protein_names_refseq": "40S ribosomal protein S11; small ribosomal subunit protein uS17", "tax_id": 10116, "disease": "", "pathway": " (rno:81774); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 2, "publication_id_list": "3838984;38843836", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04643", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0016020 membrane;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0001649 osteoblast differentiation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62282-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18421-1", "uniprot_id": [ { "id": "PSB1_RAT", "url": "https://www.uniprot.org/uniprot/P18421", "type": "external" } ], "mass": 26479.0, "length": 240, "protein_name": "Proteasome subunit beta type-1", "gene_name": "Psmb1", "organism": "Rat", "refseq_name": "proteasome subunit beta type-1 precursor", "refseq_ac": [ { "id": "NP_446042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446042", "type": "external" } ], "gene_names_uniprotkb": "Psmb1", "gene_names_refseq": "Psmb1", "protein_names_uniprotkb": "Proteasome subunit beta type-1; Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; Proteasome component C5; Proteasome gamma chain; Proteasome subunit beta-6; beta-6", "protein_names_refseq": "beta-6; macropain subunit C5; multicatalytic endopeptidase complex subunit C5; proteasome (prosome, macropain) subunit, beta type 1; proteasome beta 1 subunit; proteasome component C5; proteasome gamma chain; proteasome subunit RC5; proteasome subunit beta 1; proteasome subunit beta type-1 precursor; proteasome subunit beta type-1; proteasome subunit beta-6", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); intellectual disability (Disease Ontology:DOID:1059); microcephaly (Disease Ontology:DOID:10907); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:94198); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-6798695); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 58, "publication_count": 4, "publication_id_list": "15582157;16988215;2335242;2338147", "class_list": "", "function": "Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0051603 proteolysis involved in protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P18421-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QR88-1", "uniprot_id": [ { "id": "TIPIN_RAT", "url": "https://www.uniprot.org/uniprot/Q4QR88", "type": "external" } ], "mass": 31137.0, "length": 276, "protein_name": "TIMELESS-interacting protein", "gene_name": "LOC120094818; Tipin", "organism": "Rat", "refseq_name": "TIMELESS-interacting protein", "refseq_ac": [ { "id": "NP_001020458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020458", "type": "external" } ], "gene_names_uniprotkb": "LOC120094818; Tipin; LOC120094818; Tipin", "gene_names_refseq": "RGD1564084; Tipin; UV98", "protein_names_uniprotkb": "TIMELESS-interacting protein", "protein_names_refseq": "TIMELESS-interacting protein", "tax_id": 10116, "disease": "", "pathway": " (rno:363076)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in the control of DNA replication and the maintenance of replication fork stability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0031298 replication fork protection complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0008284 positive regulation of cell population proliferation;GO:0051301 cell division;GO:0009411 response to UV;GO:0031573 mitotic intra-S DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QR88-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08727-1", "uniprot_id": [ { "id": "TR11B_RAT", "url": "https://www.uniprot.org/uniprot/O08727", "type": "external" } ], "mass": 46192.0, "length": 401, "protein_name": "Tumor necrosis factor receptor superfamily member 11B", "gene_name": "Tnfrsf11b", "organism": "Rat", "refseq_name": "tumor necrosis factor receptor superfamily member 11B precursor", "refseq_ac": [ { "id": "NP_037002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037002", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf11b; Opg", "gene_names_refseq": "Opg; Tnfrsf11b", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 11B; Osteoprotegerin", "protein_names_refseq": "Osteoprotegerin; tumor necrosis factor receptor superfamily member 11B precursor", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); lupus nephritis (Disease Ontology:DOID:0080162); Paget's disease of bone 5 (Disease Ontology:DOID:0081368); hereditary arterial and articular multiple calcification syndrome (Disease Ontology:DOID:0111582); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); hypertension (Disease Ontology:DOID:10763); osteoporosis (Disease Ontology:DOID:11476); nephrotic syndrome (Disease Ontology:DOID:1184); secondary hyperparathyroidism (Disease Ontology:DOID:12466); aortic valve stenosis (Disease Ontology:DOID:1712); bipolar disorder (Disease Ontology:DOID:3312); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); peripheral vascular disease (Disease Ontology:DOID:341); cerebral infarction (Disease Ontology:DOID:3526); coronary stenosis (Disease Ontology:DOID:4248); Paget's disease of bone (Disease Ontology:DOID:5408); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); periapical periodontitis (Disease Ontology:DOID:823); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:25341); (R-RNO-5669034)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11839361;33834668;34610044;34948030;35842599;38923421;9108485", "class_list": "", "function": "Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model., [RefSeq, PubMed]; Except for the period of time in tooth eruption, where osteoclast formation is needed to form an eruption pathway, secretion of OPG (osteoprotegerin) prevents resorption of alveolar bone and subsequent disruption of the periodontal ligament, [RefSeq, PubMed]; Mechanical force regulates root resorption in rats through RANKL and OPG. Publication Status: Online-Only, [RefSeq, PubMed]; The Influence of Prenatal Fumonisin Exposure on Bone Properties, as well as OPG and RANKL Expression and Immunolocalization, in Newborn Offspring Is Sex and Dose Dependent. Publication Status: Online-Only, [RefSeq, PubMed]; The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis. Publication Status: Online-Only, [RefSeq, PubMed]; [Effect of different orthodontic forces on the expression of T helper cell 17 cell-related cytokines in the pressure side of periodontal tissue in rats]., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1904399 heparan sulfate binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0043235 receptor complex;GO:0005576 extracellular region", "go_biological_process": "GO:0042489 negative regulation of odontogenesis of dentin-containing tooth;GO:0046685 response to arsenic-containing substance;GO:0007584 response to nutrient;GO:0030198 extracellular matrix organization;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O08727-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZV7-1", "uniprot_id": [ { "id": "TMUB2_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZV7", "type": "external" } ], "mass": 34022.0, "length": 319, "protein_name": "Transmembrane and ubiquitin-like domain-containing protein 2", "gene_name": "Tmub2", "organism": "Rat", "refseq_name": "transmembrane and ubiquitin-like domain-containing protein 2", "refseq_ac": [ { "id": "NP_001026821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026821", "type": "external" } ], "gene_names_uniprotkb": "Tmub2", "gene_names_refseq": "RGD1304758; Tmub2", "protein_names_uniprotkb": "Transmembrane and ubiquitin-like domain-containing protein 2", "protein_names_refseq": "transmembrane and ubiquitin-like domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:303567)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5P8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZV7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62078-1", "uniprot_id": [ { "id": "TIM8B_RAT", "url": "https://www.uniprot.org/uniprot/P62078", "type": "external" } ], "mass": 9286.0, "length": 83, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim8 B", "gene_name": "Timm8b", "organism": "Rat", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim8 B", "refseq_ac": [ { "id": "NP_071986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071986", "type": "external" } ], "gene_names_uniprotkb": "Timm8b; Ddp2; Tim8b", "gene_names_refseq": "Ddp2; Timm8b", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim8 B; Deafness dystonia protein 2 homolog", "protein_names_refseq": "deafness dystonia protein 2 homolog; mitochondrial import inner membrane translocase subunit Tim8 B; small zinc finger-like protein DDP2", "tax_id": 10116, "disease": "deafness-dystonia-optic neuronopathy syndrome (Disease Ontology:DOID:0050757)", "pathway": " (rno:64372)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10611480;29393594", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space., [UniProtKB, UniProtKB]; Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QUT4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62078-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM35-1", "uniprot_id": [ { "id": "PSB10_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM35", "type": "external" } ], "mass": 29038.0, "length": 273, "protein_name": "Proteasome subunit beta type-10", "gene_name": "Ctrl; Psmb10", "organism": "Rat", "refseq_name": "proteasome subunit beta type-10", "refseq_ac": [ { "id": "NP_001020808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020808", "type": "external" } ], "gene_names_uniprotkb": "Ctrl; Psmb10; Ctrl; Lmp10; Mecl1; Psmb10", "gene_names_refseq": "Psmb10", "protein_names_uniprotkb": "Proteasome subunit beta type-10; 3.4.25.1; Low molecular mass protein 10; Macropain subunit MECl-1; Multicatalytic endopeptidase complex subunit MECl-1; Proteasome MECl-1; Proteasome subunit beta-2i", "protein_names_refseq": "low molecular mass protein 10; macropain subunit MECl-1; multicatalytic endopeptidase complex subunit MECl-1; proteasome (prosome, macropain) subunit, beta type 10; proteasome MECl-1; proteasome subunit beta 10; proteasome subunit beta type-10; proteasome subunit beta-2i", "tax_id": 10116, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010); proteosome-associated autoinflammatory syndrome 5 (Disease Ontology:DOID:0060919); immunodeficiency 121 (Disease Ontology:DOID:0061087)", "pathway": " (rno:117184); (rno:291983); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-9907900); (R-RNO-9912633)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "16988215", "class_list": "", "function": "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:1990111 spermatoproteasome complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0000902 cell morphogenesis;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0042098 T cell proliferation;GO:0006508 proteolysis;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM35-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q501W4-1", "uniprot_id": [ { "id": "VTCN1_RAT", "url": "https://www.uniprot.org/uniprot/Q501W4", "type": "external" } ], "mass": 30664.0, "length": 282, "protein_name": "V-set domain-containing T-cell activation inhibitor 1", "gene_name": "Vtcn1", "organism": "Rat", "refseq_name": "V-set domain-containing T-cell activation inhibitor 1 precursor", "refseq_ac": [ { "id": "NP_001019415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019415", "type": "external" } ], "gene_names_uniprotkb": "Vtcn1", "gene_names_refseq": "RGD1311204; Vtcn1", "protein_names_uniprotkb": "V-set domain-containing T-cell activation inhibitor 1", "protein_names_refseq": "V-set domain-containing T-cell activation inhibitor 1 precursor; immune costimulatory protein B7-H4", "tax_id": 10116, "disease": "", "pathway": " (rno:295322)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0042130 negative regulation of T cell proliferation;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q501W4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35093-1", "uniprot_id": [ { "id": "TIM23_RAT", "url": "https://www.uniprot.org/uniprot/O35093", "type": "external" } ], "mass": 21907.0, "length": 209, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim23", "gene_name": "Timm23-ps8; Timm23", "organism": "Rat", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim23", "refseq_ac": [ { "id": "NP_062225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062225", "type": "external" } ], "gene_names_uniprotkb": "Timm23-ps8; Timm23; LOC100362432; Tim23; Timm23-ps8; Timm23b; Timm23", "gene_names_refseq": "Timm23", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim23", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim23; translocase of inner mitochondrial membrane 23 homolog", "tax_id": 10116, "disease": "muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (rno:54312)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9538267", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has a role in the activation of stress-induced mitophagy by protecting PINK1 from OMA1-mediated degradation and facilitating its accumulation at the outer mitochondrial membrane in response to depolarization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex;GO:0140494 migrasome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0010954 positive regulation of protein processing;GO:0030150 protein import into mitochondrial matrix;GO:1905242 response to 3,3',5-triiodo-L-thyronine;GO:0061734 type 2 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35093-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8J2-1", "uniprot_id": [ { "id": "UB2L6_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8J2", "type": "external" } ], "mass": 17807.0, "length": 153, "protein_name": "Ubiquitin/ISG15-conjugating enzyme E2 L6", "gene_name": "Ube2l6", "organism": "Rat", "refseq_name": "ubiquitin/ISG15-conjugating enzyme E2 L6", "refseq_ac": [ { "id": "NP_001019926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019926", "type": "external" } ], "gene_names_uniprotkb": "Ube2l6", "gene_names_refseq": "Ube2l6", "protein_names_uniprotkb": "Ubiquitin/ISG15-conjugating enzyme E2 L6; 2.3.2.23; E2 ubiquitin-conjugating enzyme L6; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme L6; ubcM8; ubiquitin carrier protein L6; ubiquitin-protein ligase L6; ubiquitin/ISG15-conjugating enzyme E2 L6", "tax_id": 10116, "disease": "", "pathway": " (rno:295704); (R-RNO-1169408); (R-RNO-5656169); (R-RNO-983168); (R-RNO-9833482); (R-RNO-9909505)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019787 ubiquitin-like protein transferase activity;GO:0043130 ubiquitin binding;GO:0042296 ISG15 transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045087 innate immune response;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0019941 modification-dependent protein catabolic process;GO:0032020 ISG15-protein conjugation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8J2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63003-1", "uniprot_id": [ { "id": "TLE5_RAT", "url": "https://www.uniprot.org/uniprot/P63003", "type": "external" } ], "mass": 22000.0, "length": 197, "protein_name": "TLE family member 5", "gene_name": "Tle5", "organism": "Rat", "refseq_name": "TLE family member 5", "refseq_ac": [ { "id": "NP_062093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062093", "type": "external" } ], "gene_names_uniprotkb": "Tle5; Aes; Esp1; Grg5; Grg", "gene_names_refseq": "Aes; Grg-5; Grg; Tle5", "protein_names_uniprotkb": "TLE family member 5; Amino enhancer of split; Amino-terminal enhancer of split; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG; R-esp1", "protein_names_refseq": "R-esp1; TLE family member 5; amino enhancer of split; amino-terminal enhancer of split; groucho-related protein 5; related to Drosophila groucho", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); spondylometaepiphyseal dysplasia, short limb-hand type (Disease Ontology:DOID:0112196); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); colon cancer (Disease Ontology:DOID:219); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); adenosquamous gallbladder carcinoma (Disease Ontology:DOID:5627); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:29466)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;8245004", "class_list": "", "function": "Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q06195;Q3MIF3", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0040008 regulation of growth", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63003-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA63-1", "uniprot_id": [ { "id": "TM147_RAT", "url": "https://www.uniprot.org/uniprot/Q2TA63", "type": "external" } ], "mass": 25291.0, "length": 224, "protein_name": "BOS complex subunit TMEM147", "gene_name": "Tmem147", "organism": "Rat", "refseq_name": "BOS complex subunit TMEM147", "refseq_ac": [ { "id": "NP_001033583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033583", "type": "external" } ], "gene_names_uniprotkb": "Tmem147", "gene_names_refseq": "RGD1304706; Tmem147", "protein_names_uniprotkb": "BOS complex subunit TMEM147; Transmembrane protein 147", "protein_names_refseq": "BOS complex subunit TMEM147; seven transmembrane domain protein", "tax_id": 10116, "disease": "", "pathway": " (rno:292792)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex;GO:0160064 multi-pass translocon complex", "go_biological_process": "GO:0036228 protein localization to nuclear inner membrane;GO:0160063 multi-pass transmembrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TA63-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35704-1", "uniprot_id": [ { "id": "PRDX2_RAT", "url": "https://www.uniprot.org/uniprot/P35704", "type": "external" } ], "mass": 21784.0, "length": 198, "protein_name": "Peroxiredoxin-2", "gene_name": "Prdx2", "organism": "Rat", "refseq_name": "peroxiredoxin-2", "refseq_ac": [ { "id": "NP_058865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058865", "type": "external" } ], "gene_names_uniprotkb": "Prdx2; Tdpx1", "gene_names_refseq": "Prdx2; Tdpx1", "protein_names_uniprotkb": "Peroxiredoxin-2; 1.11.1.24; TSA; Thiol-specific antioxidant protein; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2", "protein_names_refseq": "TSA; peroxiredoxin-2; thiol-specific antioxidant protein; thioredoxin peroxidase 1; thioredoxin-dependent peroxide reductase 1; thioredoxin-dependent peroxiredoxin 2", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:29338); (R-RNO-3299685); (R-RNO-5628897)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "28100784;30655626;31273681;32279622;33268762;34502162;8041738", "class_list": "", "function": "Effects of the Prdx2 depletion on blood pressure and life span in spontaneously hypertensive rats., [RefSeq, PubMed]; Intracerebral Hemorrhage-Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2. Erratum:[Transl Stroke Res. 2020 Dec;11(6):1364-1365. doi: 10.1007/s12975-019-00720-z. PMID: 31399899], [RefSeq, PubMed]; Peroxiredoxin2 (Prdx2) Reduces Oxidative Stress and Apoptosis of Myocardial Cells Induced by Acute Myocardial Infarction by Inhibiting the TLR4/Nuclear Factor kappa B (NF-kappaB) Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Prx2 (Peroxiredoxin 2) as a Cause of Hydrocephalus After Intraventricular Hemorrhage., [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDV3", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0016209 antioxidant activity;GO:0008379 thioredoxin peroxidase activity;GO:0140824 thioredoxin-dependent peroxiredoxin activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0032496 response to lipopolysaccharide;GO:0043410 positive regulation of MAPK cascade;GO:0043524 negative regulation of neuron apoptotic process;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35704-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27590-1", "uniprot_id": [ { "id": "UROM_RAT", "url": "https://www.uniprot.org/uniprot/P27590", "type": "external" } ], "mass": 71062.0, "length": 644, "protein_name": "Uromodulin", "gene_name": "Umod", "organism": "Rat", "refseq_name": "uromodulin precursor", "refseq_ac": [ { "id": "NP_058778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058778", "type": "external" } ], "gene_names_uniprotkb": "Umod", "gene_names_refseq": "THP; Umod", "protein_names_uniprotkb": "Uromodulin; THP; Tamm-Horsfall urinary glycoprotein", "protein_names_refseq": "Urmodulin (Tamm-Horsfall protein); tamm-Horsfall urinary glycoprotein; uromodulin precursor", "tax_id": 10116, "disease": "autosomal dominant tubulointerstitial kidney disease (Disease Ontology:DOID:0060062); autosomal dominant tubulointerstitial kidney disease 1 (Disease Ontology:DOID:0061122); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:25128); (R-RNO-446203)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1531535;28348009;379435;7531049", "class_list": "", "function": "Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals. Protects against urinary tract infections by binding to type 1 fimbriated E.coli. Binds to bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E.coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation. Also promotes aggregation of other bacteria including K.pneumoniae, P.aeruginosa and S.mitis and so may also protect against other uropathogens., [UniProtKB, UniProtKB]; Two forms of uromodulin (polymerization competent and polymerization incompetent) were found in urine from both Wistar-Kyoto and SHRSP, where the polymerization-incompetent form was increased in a pregnancy-specific manner in stroke-prone spontaneously hypertensive rats., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q642D6", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0019864 IgG binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0072070 loop of Henle development;GO:0071918 urea transmembrane transport;GO:0051223 regulation of protein transport;GO:0030644 intracellular chloride ion homeostasis;GO:0072218 metanephric ascending thin limb development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P27590-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54311-1", "uniprot_id": [ { "id": "GBB1_RAT", "url": "https://www.uniprot.org/uniprot/P54311", "type": "external" } ], "mass": 37377.0, "length": 340, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "gene_name": "Gnb1", "organism": "Rat", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "refseq_ac": [ { "id": "NP_112249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112249", "type": "external" } ], "gene_names_uniprotkb": "Gnb1", "gene_names_refseq": "Gnb1", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Transducin beta chain 1", "protein_names_refseq": "Guanine nucleotide-binding protein beta 1; guanine nucleotide binding protein (G protein), beta 1; guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide binding protein, beta 1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; guanine nucleotide-binding protein, beta-1 subunit; transducin beta chain 1", "tax_id": 10116, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); myelodysplastic syndrome (Disease Ontology:DOID:0050908); autosomal dominant intellectual developmental disorder 42 (Disease Ontology:DOID:0070072); xeroderma pigmentosum group E (Disease Ontology:DOID:0110846); congestive heart failure (Disease Ontology:DOID:6000); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:24400); (R-RNO-1296041); (R-RNO-202040); (R-RNO-2485179); (R-RNO-381676); (R-RNO-392170); (R-RNO-392451); (R-RNO-400042); (R-RNO-4086398); (R-RNO-416476); (R-RNO-418594); (R-RNO-418597); (R-RNO-420092); (R-RNO-428930); (R-RNO-432040); (R-RNO-456926); (R-RNO-6814122); (R-RNO-8964616); (R-RNO-9717207); (R-RNO-9856530); (R-RNO-997272)", "pathway_count": 21, "publication_count": 4, "publication_id_list": "18683930;22673903;25941381;9221795", "class_list": "", "function": "G-protein betagamma subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity., [RefSeq, PubMed]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (By similarity). The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6Q8B1;Q9QWG8", "ec_number_list": [], "go_molecular_function": "GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity;GO:0003924 GTPase activity;GO:0030507 spectrin binding;GO:0044877 protein-containing complex binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0044297 cell body", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0008283 cell population proliferation;GO:0071456 cellular response to hypoxia;GO:0060041 retina development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P54311-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41034-1", "uniprot_id": [ { "id": "TTPA_RAT", "url": "https://www.uniprot.org/uniprot/P41034", "type": "external" } ], "mass": 31846.0, "length": 278, "protein_name": "Alpha-tocopherol transfer protein", "gene_name": "Ttpa", "organism": "Rat", "refseq_name": "alpha-tocopherol transfer protein isoform 1", "refseq_ac": [ { "id": "NP_037180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037180", "type": "external" } ], "gene_names_uniprotkb": "Ttpa; Tpp1", "gene_names_refseq": "TTP; Ttpa; alpha-TTP", "protein_names_uniprotkb": "Alpha-tocopherol transfer protein; Alpha-TTP", "protein_names_refseq": "Tocopherol transfer protein alpha; alpha-tocopherol transfer protein isoform 1; alpha-tocopherol transfer protein-like; tocopherol (alpha) transfer protein", "tax_id": 10116, "disease": "familial isolated deficiency of vitamin E (Disease Ontology:DOID:0090028); liver benign neoplasm (Disease Ontology:DOID:916)", "pathway": " (rno:25571); (R-RNO-8877627)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "22147702;23535541;24231105;25866300;8349655", "class_list": "", "function": "Alpha-TTP protects against CQ toxicity by preventing CQ accumulation in acidic organelles through a mechanism distinct from vitamin E transport., [RefSeq, PubMed]; Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositolphosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity)., [UniProtKB]; Liver X receptor regulates alpha-TTP expression through direct interaction with the alpha-TTP gene promoter, and it modulates circulating alpha-tocopherol levels., [RefSeq, PubMed]; The Goto-Kakizaki (GK) rats showed an increase of the hepatic expression of the alpha-TTP gene as compared with ... controls. ... the increased hepatic alpha-TTP gene expression levels may influence plasma alpha-tocopherol levels in the diabetic animals., [RefSeq, PubMed]; The reduced expression of hepatic alpha-TTP and CYP4F2 genes probably leads to decreased plasma alpha-tocopherol levels and elevated alpha-tocopherol levels in the liver of streptozotocin rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0019842 vitamin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0008431 vitamin E binding", "go_cellular_component": "GO:0005770 late endosome", "go_biological_process": "GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0007584 response to nutrient;GO:0001890 placenta development;GO:0009636 response to toxic substance;GO:0009268 response to pH", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P41034-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88496-1", "uniprot_id": [ { "id": "VKGC_RAT", "url": "https://www.uniprot.org/uniprot/O88496", "type": "external" } ], "mass": 87479.0, "length": 758, "protein_name": "Vitamin K-dependent gamma-carboxylase", "gene_name": "Ggcx", "organism": "Rat", "refseq_name": "vitamin K-dependent gamma-carboxylase", "refseq_ac": [ { "id": "NP_113944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113944", "type": "external" } ], "gene_names_uniprotkb": "Ggcx", "gene_names_refseq": "Ggcx; VKGC", "protein_names_uniprotkb": "Vitamin K-dependent gamma-carboxylase; 4.1.1.90; Gamma-glutamyl carboxylase; Peptidyl-glutamate 4-carboxylase; VKGC; Vitamin K gamma glutamyl carboxylase", "protein_names_refseq": "peptidyl-glutamate 4-carboxylase; vitamin K gamma glutamyl carboxylase; vitamin K-dependent gamma-carboxylase; vitamin K-dependent gamma-glutamyl carboxylase", "tax_id": 10116, "disease": "urolithiasis (Disease Ontology:DOID:0080653); combined deficiency of vitamin K-dependent clotting factors 1 (Disease Ontology:DOID:0112173)", "pathway": " (rno:81716); (R-RNO-159740)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15075329;23118128;27488359;27846632;38843836;9704005;9743593", "class_list": "", "function": "Gamma-Carboxylase inhibition prevents osteocalcin carboxylation and protects against diabetic cardiomyopathy, possibly through direct action on upregulated G protein-coupled receptor family C group 6 member A and indirectly via adiponectin., [RefSeq, PubMed]; In a rat model of chronic kidney disease, there was a decrease in the thoracic aorta expression of Vkor and Ggcx enzymes, and a decrease in the kidney level of vitamin K1 to MK-4 bioconversion enzyme Ubiad1., [RefSeq, PubMed]; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant epoxidation of vitamin K hydroquinone to vitamin K epoxide (By similarity). Couples epoxidation and carboxylation in the same active site (By similarity). Catalyzes gamma-carboxylation of blood coagulation factors (F2, F7, F9 and F10) and anticoagulants such as PROC, which are essential for thrombosis (By similarity). Catalyzes gamma-carboxylation of osteocalcin/BGLAP, which is essential for bone metabolism (By similarity). Catalyzes gamma-carboxylation of matrix Gla protein (MGP) and other transmembrane gamma-Gla proteins such as PRRG2, which are essential for calcium homeostasis and haemostasis (By similarity)., [UniProtKB, UniProtKB]; Reduced gamma-Carboxylated MGP (cMGP), through an impaired expression of gamma-carboxylase, is involved in the early development of Medial artery calcification (MAC)in diabetes., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" }, { "id": "3.4.21.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6", "type": "external" }, { "id": "3.4.21.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21", "type": "external" } ], "go_molecular_function": "GO:0019842 vitamin binding;GO:0008289 lipid binding;GO:0042277 peptide binding;GO:0008488 gamma-glutamyl carboxylase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1903011 negative regulation of bone development;GO:0010042 response to manganese ion;GO:0046929 negative regulation of neurotransmitter secretion;GO:0033280 response to vitamin D;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O88496-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498M4-1", "uniprot_id": [ { "id": "WDR5_RAT", "url": "https://www.uniprot.org/uniprot/Q498M4", "type": "external" } ], "mass": 36588.0, "length": 334, "protein_name": "WD repeat-containing protein 5", "gene_name": "Wdr5", "organism": "Rat", "refseq_name": "WD repeat-containing protein 5", "refseq_ac": [ { "id": "NP_001034123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034123", "type": "external" } ], "gene_names_uniprotkb": "Wdr5", "gene_names_refseq": "Wdr5", "protein_names_uniprotkb": "WD repeat-containing protein 5", "protein_names_refseq": "WD repeat-containing protein 5-like; WD repeat-containing protein 5", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (rno:362093); (R-RNO-201722); (R-RNO-3214841); (R-RNO-3214847); (R-RNO-3214858); (R-RNO-3769402); (R-RNO-8936459); (R-RNO-8951664); (R-RNO-9772755); (R-RNO-9909649); (R-RNO-9943962)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "15860628", "class_list": "", "function": "Contributes to histone modification (By similarity). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (By similarity). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0042800 histone H3K4 methyltransferase activity;GO:0140004 histone H3Q5ser reader activity;GO:0140109 histone H3K4me1 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035097 histone methyltransferase complex;GO:0044666 MLL3/4 complex;GO:0048188 Set1C/COMPASS complex", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0031175 neuron projection development;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q498M4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29534-1", "uniprot_id": [ { "id": "VCAM1_RAT", "url": "https://www.uniprot.org/uniprot/P29534", "type": "external" } ], "mass": 81246.0, "length": 739, "protein_name": "Vascular cell adhesion protein 1", "gene_name": "Vcam1", "organism": "Rat", "refseq_name": "vascular cell adhesion protein 1 precursor", "refseq_ac": [ { "id": "NP_037021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037021", "type": "external" } ], "gene_names_uniprotkb": "Vcam1; Vcam-1", "gene_names_refseq": "VCAM1B; Vcam1", "protein_names_uniprotkb": "Vascular cell adhesion protein 1; V-CAM 1; VCAM-1", "protein_names_refseq": "V-CAM 1; VCAM-1; vascular cell adhesion protein 1 precursor; vascular cell adhesion protein 1-like; vascular cell adhesion protein 1", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); lupus nephritis (Disease Ontology:DOID:0080162); aortic atherosclerosis (Disease Ontology:DOID:10230); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); thromboangiitis obliterans (Disease Ontology:DOID:12918); carotid stenosis (Disease Ontology:DOID:13001); interstitial cystitis (Disease Ontology:DOID:13949); pancreatic cancer (Disease Ontology:DOID:1793); essential thrombocythemia (Disease Ontology:DOID:2224); anemia (Disease Ontology:DOID:2355); glomerulonephritis (Disease Ontology:DOID:2921); carotid artery disease (Disease Ontology:DOID:3407); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); aortic disease (Disease Ontology:DOID:520); pulmonary hypertension (Disease Ontology:DOID:6432); gastrointestinal system disease (Disease Ontology:DOID:77); chronic kidney disease (Disease Ontology:DOID:784); periodontitis (Disease Ontology:DOID:824); rheumatic myocarditis (Disease Ontology:DOID:8481); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:25361); (R-RNO-198933); (R-RNO-216083)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1371918;1377031;28167758;29393594;34492249;36177783;36273220;36641679", "class_list": "", "function": "Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Does daily fasting shielding kidney on hyperglycemia-related inflammatory cytokine via TNF-alpha, NLRP3, TGF-beta1 and VCAM-1 mRNA expression., [RefSeq, PubMed]; Down-regulation of miR-204-5p ameliorates sevoflurane-induced brain injury in neonatal rats through targeting VCAM1., [RefSeq, PubMed]; Mesenchymal stem cell aggregation mediated by integrin alpha4/VCAM-1 after intrathecal transplantation in MCAO rats. Publication Status: Online-Only, [RefSeq, PubMed]; VCAM1 Drives Vascular Inflammation Leading to Continuous Cortical Neuronal Loss Following Chronic Cerebral Hypoperfusion., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5FVS3;Q63669", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0050839 cell adhesion molecule binding;GO:0008131 primary methylamine oxidase activity;GO:0098631 cell adhesion mediator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0060384 innervation;GO:0022614 membrane to membrane docking;GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P29534-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97584-1", "uniprot_id": [ { "id": "PTGR1_RAT", "url": "https://www.uniprot.org/uniprot/P97584", "type": "external" } ], "mass": 35718.0, "length": 329, "protein_name": "Prostaglandin reductase 1", "gene_name": "Ptgr1", "organism": "Rat", "refseq_name": "prostaglandin reductase 1", "refseq_ac": [ { "id": "NP_620218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620218", "type": "external" } ], "gene_names_uniprotkb": "Ptgr1; Dig1; Ltb4dh", "gene_names_refseq": "Dig1; Ltb4dh; Ptgr1", "protein_names_uniprotkb": "Prostaglandin reductase 1; 1.3.1.48; 1.3.1.74; 15-oxoprostaglandin 13-reductase; D3T-inducible gene 1 protein; DIG-1; Dithiolethione-inducible gene 1 protein; Leukotriene B4 12-hydroxydehydrogenase; NAD(P)H-dependent alkenal/one oxidoreductase; PRG-1", "protein_names_refseq": "15-oxoprostaglandin 13-reductase; D3T-inducible gene 1 protein; DIG-1; NAD(P)H-dependent alkenal/one oxidoreductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PRG-1; dithiolethione-inducible gene 1 protein; dithiolethione-inducible gene-1; prostaglandin reductase 1", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:192227)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11524419;18500801;23878198;24853774;27867096;8968041", "class_list": "", "function": "NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (By similarity). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (By similarity) (PubMed:11524419). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:11524419). Inactivates 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (PubMed:11524419)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Ptgr1 was overexpressed during the early phase in altered hepatocyte foci, and this high level of expression was maintained in persistent nodules until tumors developed. Ptgr1 expression was regulated by NRF2, which bound to an antioxidant response element at -653bp in the rat Ptgr1 gene., [RefSeq, PubMed]; The increased expression and activity of PTGR1 in liver carcinogenesis encourage further research aimed at understanding the metabolic role of PTGR1 in HCC and its potential application for human cancer diagnosis and treatment, [RefSeq, PubMed]; These data showed unequivocally that Ltb4dh mediated net trans-addition of hydrogen to (R)-perillaldehyde but followed the opposite stereochemical course (net syn-addition) for (S)-perillaldehyde., [RefSeq, PubMed]; These results situate PtGR-1 as a critical modulator of both the steady state levels and signaling activities of fatty acid nitroalkenes in vivo., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EBD3", "ec_number_list": [ { "id": "1.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.48", "type": "external" }, { "id": "1.3.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.74", "type": "external" } ], "go_molecular_function": "GO:0047522 15-oxoprostaglandin 13-reductase [NAD(P)+] activity;GO:0035798 2-alkenal reductase (NADPH) activity;GO:0036185 13-lipoxin reductase activity;GO:0097257 leukotriene B4 12-hydroxy dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0006693 prostaglandin metabolic process;GO:0050928 negative regulation of positive chemotaxis;GO:0097327 response to antineoplastic agent;GO:0036102 leukotriene B4 metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97584-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR92-1", "uniprot_id": [ { "id": "TPST1_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR92", "type": "external" } ], "mass": 42135.0, "length": 370, "protein_name": "Protein-tyrosine sulfotransferase 1", "gene_name": "Tpst1", "organism": "Rat", "refseq_name": "protein-tyrosine sulfotransferase 1", "refseq_ac": [ { "id": "NP_001011903", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011903", "type": "external" } ], "gene_names_uniprotkb": "Tpst1", "gene_names_refseq": "Tpst1", "protein_names_uniprotkb": "Protein-tyrosine sulfotransferase 1; 2.8.2.20; TPST-1; Tyrosylprotein sulfotransferase 1", "protein_names_refseq": "TPST-1; protein-tyrosine sulfotransferase 1", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (rno:288617); (R-RNO-156584); (R-RNO-163841)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9501187", "class_list": "", "function": "Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.20", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008476 protein-tyrosine sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0043687 post-translational protein modification;GO:0006478 peptidyl-tyrosine sulfation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KR92-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49745-1", "uniprot_id": [ { "id": "TPO_RAT", "url": "https://www.uniprot.org/uniprot/P49745", "type": "external" } ], "mass": 34556.0, "length": 326, "protein_name": "Thrombopoietin", "gene_name": "Thpol1; Thpo", "organism": "Rat", "refseq_name": "thrombopoietin precursor", "refseq_ac": [ { "id": "NP_112395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112395", "type": "external" } ], "gene_names_uniprotkb": "Thpol1; Thpo; Thpol1; Thpo", "gene_names_refseq": "Thpol1; Thpo", "protein_names_uniprotkb": "Thrombopoietin", "protein_names_refseq": "thrombopoietin precursor; thrombopoietin", "tax_id": 10116, "disease": "congenital amegakaryocytic thrombocytopenia 2 (Disease Ontology:DOID:0061002); aplastic anemia (Disease Ontology:DOID:12449); toxic shock syndrome (Disease Ontology:DOID:14115); thrombocytopenia (Disease Ontology:DOID:1588); essential thrombocythemia (Disease Ontology:DOID:2224); thrombocytosis (Disease Ontology:DOID:2228); liver cirrhosis (Disease Ontology:DOID:5082); arteriosclerosis obliterans (Disease Ontology:DOID:5160); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:81811)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "26116151;7607561", "class_list": "", "function": "Fourteen channels of thrombopoietin signaling pathway participated in regulating hepatocyte activation during rat liver regeneration., [RefSeq, PubMed]; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005125 cytokine activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0043235 receptor complex", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0001934 positive regulation of protein phosphorylation;GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P49745-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59924-1", "uniprot_id": [ { "id": "THOC1_RAT", "url": "https://www.uniprot.org/uniprot/P59924", "type": "external" } ], "mass": 40243.0, "length": 343, "protein_name": "THO complex subunit 1", "gene_name": "Thoc1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Thoc1; Da2-19", "gene_names_refseq": "", "protein_names_uniprotkb": "THO complex subunit 1; Liver regeneration-related protein LRRG175; Nuclear matrix protein p84", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant nonsyndromic deafness 86 (Disease Ontology:DOID:0070610)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (By similarity). Required for efficient export of polyadenylated RNA (By similarity). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B (By similarity). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (By similarity). Regulates transcriptional elongation of a subset of genes (By similarity). Involved in genome stability by preventing co-transcriptional R-loop formation (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1. Essential for early embryonic development. Required for normal gene expression during postnatal testis development (By similarity). May play a role in hair cell formation, hence may be involved in hearing (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016363 nuclear matrix;GO:0000347 THO complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0007165 signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P59924-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49242-1", "uniprot_id": [ { "id": "RS3A_RAT", "url": "https://www.uniprot.org/uniprot/P49242", "type": "external" } ], "mass": 29945.0, "length": 264, "protein_name": "Small ribosomal subunit protein eS1", "gene_name": "LOC100365839; Rps3a", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS1", "refseq_ac": [ { "id": "NP_058849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058849", "type": "external" } ], "gene_names_uniprotkb": "LOC100365839; Rps3a; Fte-1; Fte1; LOC100365839; RPS3A", "gene_names_refseq": "Rps3a", "protein_names_uniprotkb": "Small ribosomal subunit protein eS1; 40S ribosomal protein S3a; V-fos transformation effector protein", "protein_names_refseq": "40S ribosomal protein S3a; V-fos transformation effector protein; small ribosomal subunit protein eS1", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (rno:100365839); (rno:29288); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 6, "publication_id_list": "1549582;38843836;8910435;8912649;9074506;925037", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity)., [UniProtKB, UniProtKB, HAMAP]; May play a role during erythropoiesis through regulation of transcription factor DDIT3., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P33443", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0048027 mRNA 5'-UTR binding;GO:0003735 structural constituent of ribosome;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0045471 response to ethanol;GO:0006412 translation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P49242-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30083-1", "uniprot_id": [ { "id": "VIPR1_RAT", "url": "https://www.uniprot.org/uniprot/P30083", "type": "external" } ], "mass": 52058.0, "length": 459, "protein_name": "Vasoactive intestinal polypeptide receptor 1", "gene_name": "AABR07071765.1; Vipr1", "organism": "Rat", "refseq_name": "vasoactive intestinal polypeptide receptor 1 precursor", "refseq_ac": [ { "id": "NP_036817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036817", "type": "external" } ], "gene_names_uniprotkb": "AABR07071765.1; Vipr1; Vipr1", "gene_names_refseq": "PACAP-R-2; PACAP-R2; RATVASREC; RGD1564352; VASREC; VIP-R-1; Vipr1", "protein_names_uniprotkb": "Vasoactive intestinal polypeptide receptor 1; PACAP type II receptor; PACAP-R-2; PACAP-R2; Pituitary adenylate cyclase-activating polypeptide type II receptor; VIP-R-1", "protein_names_refseq": "PACAP type II receptor; pituitary adenylate cyclase-activating polypeptide type II receptor; vasoactive intestinal polypeptide receptor 1 precursor; vasoactive intestinal polypeptide receptor 1", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); achalasia (Disease Ontology:DOID:9164)", "pathway": " (rno:24875); (R-RNO-420092)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "12220728;1314625;23518767;24801739;28776455;33098516;36430275;8948424", "class_list": "", "function": "Characterization of this receptor in cultured rat penis corpus cavernosum smooth muscle cells and its interaction with guanylate cyclase-B receptors, [RefSeq, PubMed]; G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In cultured rat conjunctival goblet cells, VPAC1 and 2 receptors are functional; VIP stimulates a cAMP-dependent increase in [Ca(2+)]i and glycoconjugate secretion, but not ERK1/2 activation. Publication Status: Online-Only, [RefSeq, PubMed]; PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies. Publication Status: Online-Only, [RefSeq, PubMed]; Stimulating hippocampal microglia with the peptide neurotransmitter VIP via VPAC1 receptors increases production of IL-4 which promotes their trophic and proliferative effects on neural stem/progenitor cells, [RefSeq, PubMed]; The protein and mRNA expression of pituitary adenylate cyclase-activating polypeptide-related receptors (PAC1, VPAC1, and VPAC2) in the trigeminal ganglia and trigeminal nucleus caudalis to identify changes associated with repetitive applications of chemical dural stimulations., [RefSeq, PubMed]; Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity;GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004999 vasoactive intestinal polypeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P30083-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09330-1", "uniprot_id": [ { "id": "PRPS2_RAT", "url": "https://www.uniprot.org/uniprot/P09330", "type": "external" } ], "mass": 34813.0, "length": 318, "protein_name": "Ribose-phosphate pyrophosphokinase 2", "gene_name": "Prps1l1; Prps1l3; Prps1; Prps2", "organism": "Rat", "refseq_name": "ribose-phosphate pyrophosphokinase 2", "refseq_ac": [ { "id": "NP_036766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036766", "type": "external" } ], "gene_names_uniprotkb": "Prps1l1; Prps1l3; Prps1; Prps2; Prps1l1; Prps1l3; Prps2", "gene_names_refseq": "Prps2", "protein_names_uniprotkb": "Ribose-phosphate pyrophosphokinase 2; 2.7.6.1; PRS-II; Phosphoribosyl pyrophosphate synthase II", "protein_names_refseq": "PRS-II; Phophoribosylpyrophosphate synthetase, subunit II; phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase II; ribose-phosphate pyrophosphokinase 2-like; ribose-phosphate pyrophosphokinase 2", "tax_id": 10116, "disease": "Arts syndrome (Disease Ontology:DOID:0050647); limb ischemia (Disease Ontology:DOID:0050852); familial erythrocytosis 5 (Disease Ontology:DOID:0080290); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210); phosphoribosylpyrophosphate synthetase superactivity (Disease Ontology:DOID:0111260); X-linked deafness 1 (Disease Ontology:DOID:0111739); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); neurodegenerative disease (Disease Ontology:DOID:1289); retinopathy of prematurity (Disease Ontology:DOID:13025); gout (Disease Ontology:DOID:13189); porphyria (Disease Ontology:DOID:13268); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); placental insufficiency (Disease Ontology:DOID:3891); macular retinal edema (Disease Ontology:DOID:4449); cholangiocarcinoma (Disease Ontology:DOID:4947); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); vascular dementia (Disease Ontology:DOID:8725); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:24689); (rno:298954); (rno:314140); (R-RNO-73843)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "2555778;2822704", "class_list": "", "function": "Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63462", "ec_number_list": [ { "id": "2.7.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.6.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016208 AMP binding", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006098 pentose-phosphate shunt;GO:0031100 animal organ regeneration;GO:0006167 AMP biosynthetic process;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P09330-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10111-1", "uniprot_id": [ { "id": "PPIA_RAT", "url": "https://www.uniprot.org/uniprot/P10111", "type": "external" } ], "mass": 17874.0, "length": 164, "protein_name": "Peptidyl-prolyl cis-trans isomerase A", "gene_name": "Ppia", "organism": "Rat", "refseq_name": "peptidyl-prolyl cis-trans isomerase A", "refseq_ac": [ { "id": "NP_058797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058797", "type": "external" } ], "gene_names_uniprotkb": "Ppia; Ppial4d", "gene_names_refseq": "CYCA; CyP-A; Ppia; p1B15; p31", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase A; 5.2.1.8; Cyclophilin A; Cyclosporin A-binding protein; PPIase A; Rotamase A; p1B15; p31", "protein_names_refseq": "PPIase A; cyclophilin A; cyclosporin A-binding protein; peptidyl-prolyl cis-trans isomerase A; rotamase A", "tax_id": 10116, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); Bell's palsy (Disease Ontology:DOID:12506); aggressive periodontitis (Disease Ontology:DOID:1474); epilepsy (Disease Ontology:DOID:1826); cholangiocarcinoma (Disease Ontology:DOID:4947); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:100360977); (rno:25518); (R-RNO-210991); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "1599421;1851525;2996604;30221707;3293952;37993081", "class_list": "", "function": "Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Secreted cyclophilin A is non-genotoxic but acts as a tumor promoter., [RefSeq, PubMed]; The action of Ang II was primarily dependent on the angiotensin type 2 receptor (AT2R), not the type 1 receptor. These results provided an insight into the role of the AT2R signaling pathway in Ang IIinduced myocardial hypertrophy, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P18303;Q5BK98", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0005178 integrin binding;GO:1904399 heparan sulfate binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:2001233 regulation of apoptotic signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0043410 positive regulation of MAPK cascade;GO:0001933 negative regulation of protein phosphorylation;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P10111-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62856-1", "uniprot_id": [ { "id": "RS26_RAT", "url": "https://www.uniprot.org/uniprot/P62856", "type": "external" } ], "mass": 13015.0, "length": 115, "protein_name": "Small ribosomal subunit protein eS26", "gene_name": "Rps26-ps13; Rps26l4; Rps26l6; Rps26", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS26", "refseq_ac": [ { "id": "NP_037356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037356", "type": "external" } ], "gene_names_uniprotkb": "Rps26-ps13; Rps26l4; Rps26l6; Rps26; AC126292.3; LOC100361756; LOC688948; Rps26l2; Rps26l4; Rps26l6; Rps26", "gene_names_refseq": "Rps26", "protein_names_uniprotkb": "Small ribosomal subunit protein eS26; 40S ribosomal protein S26", "protein_names_refseq": "40S ribosomal protein S26; small ribosomal subunit protein eS26", "tax_id": 10116, "disease": "Diamond-Blackfan anemia 10 (Disease Ontology:DOID:0111888); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (rno:100361756); (rno:27139); (rno:303862); (rno:688948); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 16, "publication_count": 1, "publication_id_list": "2993263", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02383;P70394;Q06722", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0005840 ribosome", "go_biological_process": "GO:0033119 negative regulation of RNA splicing;GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62856-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62246-1", "uniprot_id": [ { "id": "RS15A_RAT", "url": "https://www.uniprot.org/uniprot/P62246", "type": "external" } ], "mass": 14840.0, "length": 130, "protein_name": "Small ribosomal subunit protein uS8", "gene_name": "Rps15al4; Rps15a", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS8", "refseq_ac": [ { "id": "NP_446434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446434", "type": "external" } ], "gene_names_uniprotkb": "Rps15al4; Rps15a; AC135389.1; LOC103693101; Rps15al4; Rps15al7", "gene_names_refseq": "Rps15a", "protein_names_uniprotkb": "Small ribosomal subunit protein uS8; 40S ribosomal protein S15a", "protein_names_refseq": "40S ribosomal protein S15a; small ribosomal subunit protein uS8", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 20 (Disease Ontology:DOID:0111891)", "pathway": " (rno:100361715); (rno:117053); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "37094854;8185605", "class_list": "", "function": "Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Required for proper erythropoiesis., [UniProtKB, UniProtKB]; RPS15A Mediates PI3K/AKT Signaling-Induced Parathyroid Cell Proliferation in Rats with Secondary Hyperparathyroidism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P39027;P39031;Q8C023;Q9BV24", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0009615 response to virus;GO:0006412 translation;GO:0045787 positive regulation of cell cycle;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62246-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20289-1", "uniprot_id": [ { "id": "VEGP1_RAT", "url": "https://www.uniprot.org/uniprot/P20289", "type": "external" } ], "mass": 19726.0, "length": 177, "protein_name": "von Ebner gland protein 1", "gene_name": "Lcn1; Vegp1", "organism": "Rat", "refseq_name": "von Ebner gland protein 1 precursor", "refseq_ac": [ { "id": "NP_075234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075234", "type": "external" } ], "gene_names_uniprotkb": "Lcn1; Vegp1; Vegp2; Vegp", "gene_names_refseq": "Lcn1p1; Lcn1; Vegp1", "protein_names_uniprotkb": "von Ebner gland protein 1; VEG protein 1", "protein_names_refseq": "VEG protein 1; lipocalin 1 pseudogene 1; von Ebner gland protein 1 precursor; von Ebner gland protein 1; von Ebners gland protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:65039); (R-RNO-804914)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1689010;7514123", "class_list": "", "function": "Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0031404 chloride ion binding;GO:0036094 small molecule binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20289-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM62-1", "uniprot_id": [ { "id": "PALMD_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM62", "type": "external" } ], "mass": 62419.0, "length": 551, "protein_name": "Palmdelphin", "gene_name": "Palmd", "organism": "Rat", "refseq_name": "palmdelphin", "refseq_ac": [ { "id": "NP_001020859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020859", "type": "external" } ], "gene_names_uniprotkb": "Palmd", "gene_names_refseq": "Palmd", "protein_names_uniprotkb": "Palmdelphin", "protein_names_refseq": "palmdelphin", "tax_id": 10116, "disease": "", "pathway": " (rno:310811)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16323283;22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0016020 membrane;GO:0030425 dendrite;GO:0043197 dendritic spine", "go_biological_process": "GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KM62-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62703-1", "uniprot_id": [ { "id": "RS4X_RAT", "url": "https://www.uniprot.org/uniprot/P62703", "type": "external" } ], "mass": 29598.0, "length": 263, "protein_name": "Small ribosomal subunit protein eS4", "gene_name": "Rps4x", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS4", "refseq_ac": [ { "id": "NP_001007601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007601", "type": "external" } ], "gene_names_uniprotkb": "Rps4x; Rps4x-ps13; Rps4x-ps9; Rps4", "gene_names_refseq": "Rps4x", "protein_names_uniprotkb": "Small ribosomal subunit protein eS4; 40S ribosomal protein S4, X isoform", "protein_names_refseq": "ribosomal protein S4, X-linked X-like; small ribosomal subunit protein eS4", "tax_id": 10116, "disease": "", "pathway": " (rno:100362640); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 4, "publication_id_list": "12042320;2207170;2660908;38843836", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P12631;P12750;P27576;P55831;Q14727", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0045202 synapse;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0005840 ribosome;GO:0022626 cytosolic ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0045471 response to ethanol;GO:0006412 translation;GO:0045727 positive regulation of translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62703-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33579-1", "uniprot_id": [ { "id": "PR8A5_RAT", "url": "https://www.uniprot.org/uniprot/P33579", "type": "external" } ], "mass": 27246.0, "length": 238, "protein_name": "Prolactin-8A5", "gene_name": "Prl8a3; Prl8a4; Prl8a5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prl8a3; Prl8a4; Prl8a5; Prl8a5; Prlpc", "gene_names_refseq": "", "protein_names_uniprotkb": "Prolactin-8A5; Growth hormone-related placental protein 2; PLP-C; PRL-like protein C; Placental prolactin-like protein C", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); impulse control disorder (Disease Ontology:DOID:10937); depressive disorder (Disease Ontology:DOID:1596); severe acute respiratory syndrome (Disease Ontology:DOID:2945); carotid artery disease (Disease Ontology:DOID:3407); prolactinoma (Disease Ontology:DOID:5394); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:100361884); (rno:286889)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1744098;2351117", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P33579-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60868-1", "uniprot_id": [ { "id": "RS20_RAT", "url": "https://www.uniprot.org/uniprot/P60868", "type": "external" } ], "mass": 13373.0, "length": 119, "protein_name": "Small ribosomal subunit protein uS10", "gene_name": "LOC120103001; Rps20l1; Rps20l2; Rps20l4; Rps20", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS10", "refseq_ac": [ { "id": "NP_001007604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007604", "type": "external" } ], "gene_names_uniprotkb": "LOC120103001; Rps20l1; Rps20l2; Rps20l4; Rps20; AABR07070957.1; LOC100359563; LOC120103001; RGD1562259; RGD1563124; Rps20-ps11; Rps20l1; Rps20l2; Rps20l4", "gene_names_refseq": "Rps20", "protein_names_uniprotkb": "Small ribosomal subunit protein uS10; 40S ribosomal protein S20", "protein_names_refseq": "40S ribosomal protein S20; small ribosomal subunit protein uS10", "tax_id": 10116, "disease": "Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (rno:100359563); (rno:120103001); (rno:122772); (rno:500451); (rno:500817); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 17, "publication_count": 1, "publication_id_list": "2357470", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P17075", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0097371 MDM2/MDM4 family protein binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane", "go_biological_process": "GO:0006412 translation;GO:1901798 positive regulation of signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60868-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51583-1", "uniprot_id": [ { "id": "PUR6_RAT", "url": "https://www.uniprot.org/uniprot/P51583", "type": "external" } ], "mass": 47096.0, "length": 425, "protein_name": "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase", "gene_name": "Paics", "organism": "Rat", "refseq_name": "bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase", "refseq_ac": [ { "id": "NP_543186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543186", "type": "external" } ], "gene_names_uniprotkb": "Paics; Ade2; Airc", "gene_names_refseq": "Ade2h1; Airc; Paics", "protein_names_uniprotkb": "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; AIR carboxylase; AIRC; PAICS; SAICAR synthetase", "protein_names_refseq": "AIR carboxylase-SAICAR synthetase; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase; multifunctional protein ADE2-like; multifunctional protein ADE2; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase", "tax_id": 10116, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:140946); (R-RNO-73817)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;7742366", "class_list": "", "function": "Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.21", "type": "external" }, { "id": "6.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity;GO:0004638 phosphoribosylaminoimidazole carboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000082 G1/S transition of mitotic cell cycle;GO:0006177 GMP biosynthetic process;GO:0009113 purine nucleobase biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0044208 'de novo' AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51583-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08593-1", "uniprot_id": [ { "id": "PDE7A_RAT", "url": "https://www.uniprot.org/uniprot/O08593", "type": "external" } ], "mass": 49274.0, "length": 426, "protein_name": "High affinity 3',5'-cyclic-AMP phosphodiesterase 7A", "gene_name": "Pde7a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pde7a", "gene_names_refseq": "", "protein_names_uniprotkb": "High affinity 3',5'-cyclic-AMP phosphodiesterase 7A; 3.1.4.53; Rolipram-insensitive phosphodiesterase type 7; cAMP-specific phosphodiesterase 7A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:81744); (R-RNO-418555)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9515162", "class_list": "", "function": "Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004112 cyclic-nucleotide phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0006198 cAMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O08593-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55006-1", "uniprot_id": [ { "id": "RDH7_RAT", "url": "https://www.uniprot.org/uniprot/P55006", "type": "external" } ], "mass": 35737.0, "length": 317, "protein_name": "Retinol dehydrogenase 7", "gene_name": "Rdh7", "organism": "Rat", "refseq_name": "retinol dehydrogenase 7", "refseq_ac": [ { "id": "NP_598227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598227", "type": "external" } ], "gene_names_uniprotkb": "Rdh7; Rdh3", "gene_names_refseq": "RGD1307178; Rdh3; Rdh7; RoDH(III)", "protein_names_uniprotkb": "Retinol dehydrogenase 7; 1.1.1.105; RODH III; Retinol dehydrogenase 3; Retinol dehydrogenase type III", "protein_names_refseq": "RODH III; RODH I; hypothetical gene supported by NM_133543; retinol dehydrogenase 3; retinol dehydrogenase 7; retinol dehydrogenase type III", "tax_id": 10116, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (rno:360420); (R-RNO-5365859)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "7876135;8647450", "class_list": "", "function": "Acts on retinol bound on cellular retinol-binding protein (CRBP)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P50169;Q4KMB6", "ec_number_list": [ { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P55006-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05765-1", "uniprot_id": [ { "id": "RS21_RAT", "url": "https://www.uniprot.org/uniprot/P05765", "type": "external" } ], "mass": 9127.0, "length": 83, "protein_name": "Small ribosomal subunit protein eS21", "gene_name": "LOC100359505; Rps21", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS21", "refseq_ac": [ { "id": "NP_112373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112373", "type": "external" } ], "gene_names_uniprotkb": "LOC100359505; Rps21; Rps21", "gene_names_refseq": "Rps21", "protein_names_uniprotkb": "Small ribosomal subunit protein eS21; 40S ribosomal protein S21", "protein_names_refseq": "40S ribosomal protein S21; small ribosomal subunit protein eS21", "tax_id": 10116, "disease": "", "pathway": " (rno:100359505); (rno:81775); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "3910104;7654221", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0022627 cytosolic small ribosomal subunit;GO:0022626 cytosolic ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0002181 cytoplasmic translation;GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P05765-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88779-1", "uniprot_id": [ { "id": "RHBL1_RAT", "url": "https://www.uniprot.org/uniprot/O88779", "type": "external" } ], "mass": 17662.0, "length": 164, "protein_name": "Rhomboid-related protein 1", "gene_name": "Rhbdl1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rhbdl1; Rhbdl", "gene_names_refseq": "", "protein_names_uniprotkb": "Rhomboid-related protein 1; 3.4.21.105; RRP; Rhomboid-like protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9662444", "class_list": "", "function": "May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors., [UniProtKB, UniProtKB]; Regulator of proteosome activity independent of enzymatic activity (By similarity). May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88779-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09810-1", "uniprot_id": [ { "id": "TPH1_RAT", "url": "https://www.uniprot.org/uniprot/P09810", "type": "external" } ], "mass": 51068.0, "length": 444, "protein_name": "Tryptophan 5-hydroxylase 1", "gene_name": "Sergef; Tph1", "organism": "Rat", "refseq_name": "tryptophan 5-hydroxylase 1", "refseq_ac": [ { "id": "NP_001094104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094104", "type": "external" } ], "gene_names_uniprotkb": "Sergef; Tph1; Tph1; Tph", "gene_names_refseq": "Tph1; Tph", "protein_names_uniprotkb": "Tryptophan 5-hydroxylase 1; 1.14.16.4; Tryptophan 5-monooxygenase 1", "protein_names_refseq": "tryptophan 5-hydroxylase 1; tryptophan 5-monooxygenase 1", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); scoliosis (Disease Ontology:DOID:0060249); Alzheimer's disease (Disease Ontology:DOID:10652); borderline personality disorder (Disease Ontology:DOID:10930); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); atherosclerosis (Disease Ontology:DOID:1936); schizophrenia (Disease Ontology:DOID:5419); postpartum depression (Disease Ontology:DOID:9478); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (rno:24848); (rno:365243); (R-RNO-209931)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12354109;1645430;18705647;25930119;2875901;31124080;31997472;32641996;33750988;3379411", "class_list": "", "function": "Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis. Erratum:[PLoS One. 2022 Apr 27;17(4):e0267927. doi: 10.1371/journal.pone.0267927. PMID: 35476793] Publication Status: Online-Only, [RefSeq, PubMed]; Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; The testes of control animals express the Tph1, Aanat, and Asmt and Per2 genes with 24-h rhythms in mRNA, reaching the maximal values during the dark phase., [RefSeq, PubMed]; Tryptophan hydroxylase-1 (TPH1), an enzyme that catalyzes the reaction of Trp to serotonin, was significantly increased in liver and spleen of AT-2 engrafted rats. Further histochemical analysis revealed that the induction of TPH1 in the liver could be attributed to infiltration of mast cells., [RefSeq, PubMed]; Ursolic acid derivatives targeted to tryptophan hydroxylase 1 prevented bone loss by suppressing serotonin biosynthesis without estrogenic side-effects in ovariectomized rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.16.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.16.4", "type": "external" } ], "go_molecular_function": "GO:0004510 tryptophan 5-monooxygenase activity;GO:0005506 iron ion binding;GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043005 neuron projection;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002576 platelet degranulation;GO:0045600 positive regulation of fat cell differentiation;GO:0007623 circadian rhythm;GO:0046849 bone remodeling;GO:0060749 mammary gland alveolus development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P09810-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35932-1", "uniprot_id": [ { "id": "PD2RL_RAT", "url": "https://www.uniprot.org/uniprot/O35932", "type": "external" } ], "mass": 39803.0, "length": 357, "protein_name": "Prostaglandin D2 receptor-like", "gene_name": "Ptgdrl; Ptgdr", "organism": "Rat", "refseq_name": "prostaglandin D2 receptor-like", "refseq_ac": [ { "id": "NP_071577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071577", "type": "external" } ], "gene_names_uniprotkb": "Ptgdrl; Ptgdr; AABR07017241.1; Ptgdr2; Ptgdrl1; Ptgdrl", "gene_names_refseq": "Ptgdr2; Ptgdrl; Ptgdr", "protein_names_uniprotkb": "Prostaglandin D2 receptor-like; PGD receptor-like; PGD2 receptor-like; Prostanoid DP receptor-like", "protein_names_refseq": "prostaglandin D receptor; prostaglandin D2 receptor-like", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432); allergic asthma (Disease Ontology:DOID:9415)", "pathway": " (rno:63889); (R-RNO-391908)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12895603;31917615;6302737;9721719", "class_list": "", "function": "Amino acid sequence alignment of human, mouse and rat DP receptors (also called prostaglandin D2 receptor) Review article, [RefSeq, PubMed]; Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling., [RefSeq, PubMed]; Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004955 prostaglandin receptor activity;GO:0001785 prostaglandin J receptor activity;GO:0004956 prostaglandin D receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0060406 positive regulation of penile erection;GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35932-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14644-1", "uniprot_id": [ { "id": "PDE4C_RAT", "url": "https://www.uniprot.org/uniprot/P14644", "type": "external" } ], "mass": 60064.0, "length": 536, "protein_name": "3',5'-cyclic-AMP phosphodiesterase 4C", "gene_name": "Cist1; Pde4c", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cist1; Pde4c; Dpde1; LOC120093089; Pde4c", "gene_names_refseq": "", "protein_names_uniprotkb": "3',5'-cyclic-AMP phosphodiesterase 4C; 3.1.4.53; DPDE1; cAMP-specific phosphodiesterase 4C", "protein_names_refseq": "", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:290646); (R-RNO-180024); (R-RNO-418555)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "2546153;7958996", "class_list": "", "function": "Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005929 cilium", "go_biological_process": "GO:0007165 signal transduction;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0006198 cAMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P14644-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63326-1", "uniprot_id": [ { "id": "RS10_RAT", "url": "https://www.uniprot.org/uniprot/P63326", "type": "external" } ], "mass": 18916.0, "length": 165, "protein_name": "Small ribosomal subunit protein eS10", "gene_name": "Rps10l6; Rps10", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS10", "refseq_ac": [ { "id": "NP_112371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112371", "type": "external" } ], "gene_names_uniprotkb": "Rps10l6; Rps10; Rps10-ps20; Rps10-ps21; Rps10-ps22; Rps10l3; Rps10l5; Rps10l7; Rps10", "gene_names_refseq": "Rps10", "protein_names_uniprotkb": "Small ribosomal subunit protein eS10; 40S ribosomal protein S10", "protein_names_refseq": "40S ribosomal protein S10; small ribosomal subunit protein eS10", "tax_id": 10116, "disease": "Diamond-Blackfan anemia 9 (Disease Ontology:DOID:0111884)", "pathway": " (rno:81773); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 2, "publication_id_list": "2543570;29393594", "class_list": "", "function": "Component of the 40S ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09900;Q9DCR5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0000049 tRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0022627 cytosolic small ribosomal subunit;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63326-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29314-1", "uniprot_id": [ { "id": "RS9_RAT", "url": "https://www.uniprot.org/uniprot/P29314", "type": "external" } ], "mass": 22591.0, "length": 194, "protein_name": "Small ribosomal subunit protein uS4", "gene_name": "LOC120097492; Rps9", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS4", "refseq_ac": [ { "id": "NP_001300864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001300864", "type": "external" } ], "gene_names_uniprotkb": "LOC120097492; Rps9; LOC120097492", "gene_names_refseq": "Rps9l1; Rps9", "protein_names_uniprotkb": "Small ribosomal subunit protein uS4; 40S ribosomal protein S9", "protein_names_refseq": "40S ribosomal protein S9-like; 40S ribosomal protein S9; ribosomal protein S9-like 1; small ribosomal subunit protein uS4", "tax_id": 10116, "disease": "", "pathway": " (rno:103689992); (rno:120097492); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "38843836;8503895", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9W7", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:1990932 5.8S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0042274 ribosomal small subunit biogenesis;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P29314-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16617-1", "uniprot_id": [ { "id": "PGK1_RAT", "url": "https://www.uniprot.org/uniprot/P16617", "type": "external" } ], "mass": 44538.0, "length": 417, "protein_name": "Phosphoglycerate kinase 1", "gene_name": "Pgk1", "organism": "Rat", "refseq_name": "phosphoglycerate kinase 1", "refseq_ac": [ { "id": "NP_445743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445743", "type": "external" } ], "gene_names_uniprotkb": "Pgk1; Pgk-1; Pgk1l1", "gene_names_refseq": "Pgk1; Pgk", "protein_names_uniprotkb": "Phosphoglycerate kinase 1; 2.7.11.1; 2.7.2.3", "protein_names_refseq": "phosphoglycerate kinase 1", "tax_id": 10116, "disease": "phosphoglycerate kinase 1 deficiency (Disease Ontology:DOID:0111933); Parkinson's disease (Disease Ontology:DOID:14330); cancer (Disease Ontology:DOID:162); hemolytic anemia (Disease Ontology:DOID:583)", "pathway": " (rno:24644); (R-RNO-165159); (R-RNO-70171); (R-RNO-70263)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "18683930;22673903;2610697;29393594;34502162;36749430;37249790;37258131;37295596", "class_list": "", "function": "Activation of Pgk1 Results in Reduced Protein Aggregation in Diverse Neurodegenerative Conditions., [RefSeq, PubMed]; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis. May play a role in sperm motility., [UniProtKB, UniProtKB]; Downregulated Phosphoglycerate Kinase 1 Attenuates Cerebral Ischemia-Reperfusion Injury by Reversing Neuroinflammation and Oxidative Stress through the Nuclear Factor Erythroid 2 Related Factor 2/ARE Pathway., [RefSeq, PubMed]; Phosphoglycerate kinase (PGK) 1 succinylation modulates epileptic seizures and the blood-brain barrier., [RefSeq, PubMed]; The Role of PGK1 in Promoting Ischemia/Reperfusion Injury-Induced Microglial M1 Polarization and Inflammation by Regulating Glycolysis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M945;Q6P508", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004618 phosphoglycerate kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043531 ADP binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0045121 membrane raft", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0071456 cellular response to hypoxia;GO:0006094 gluconeogenesis;GO:0016525 negative regulation of angiogenesis;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P16617-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09014-1", "uniprot_id": [ { "id": "S15A4_RAT", "url": "https://www.uniprot.org/uniprot/O09014", "type": "external" } ], "mass": 61949.0, "length": 572, "protein_name": "Solute carrier family 15 member 4", "gene_name": "Slc15a4", "organism": "Rat", "refseq_name": "solute carrier family 15 member 4", "refseq_ac": [ { "id": "NP_653359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653359", "type": "external" } ], "gene_names_uniprotkb": "Slc15a4; Pht1", "gene_names_refseq": "Slc15a4", "protein_names_uniprotkb": "Solute carrier family 15 member 4; Peptide/histidine transporter 1; rPHT1", "protein_names_refseq": "peptide transporter 4; peptide/histidine transporter 1; rPHT1; solute carrier family 15 (oligopeptide transporter), member 4; solute carrier family 15 member 4", "tax_id": 10116, "disease": "", "pathway": " (rno:246280); (R-RNO-427975); (R-RNO-6798695); (R-RNO-9860276)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11741260;19913073;24548120;9092568", "class_list": "", "function": "Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:9092568). Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position (By similarity). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (By similarity). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (PubMed:9092568). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (By similarity). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation. Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; These findings represent the first evidence that peptide transport via SLC15a1, 2, 3, and 4 occurs in thyroid follicular cells., [RefSeq, PubMed]; We found marked changes in protein expression and functional activity of PhT1 and PepT2, the former predominating in adult and the latter in neonate, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5M931", "ec_number_list": [], "go_molecular_function": "GO:0005290 L-histidine transmembrane transporter activity;GO:0015333 peptide:proton symporter activity;GO:0071916 dipeptide transmembrane transporter activity;GO:0015647 peptidoglycan transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane;GO:0010008 endosome membrane;GO:0036020 endolysosome membrane", "go_biological_process": "GO:0048302 regulation of isotype switching to IgG isotypes;GO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0015031 protein transport;GO:0045087 innate immune response;GO:0034157 positive regulation of toll-like receptor 7 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O09014-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35231-1", "uniprot_id": [ { "id": "REG3A_RAT", "url": "https://www.uniprot.org/uniprot/P35231", "type": "external" } ], "mass": 19599.0, "length": 174, "protein_name": "Regenerating islet-derived protein 3-alpha", "gene_name": "Reg3a", "organism": "Rat", "refseq_name": "regenerating islet-derived protein 3-alpha precursor", "refseq_ac": [ { "id": "NP_001139318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139318", "type": "external" } ], "gene_names_uniprotkb": "Reg3a; Pap2; Reg3", "gene_names_refseq": "Pap2; PapII; Reg3a", "protein_names_uniprotkb": "Regenerating islet-derived protein 3-alpha; Islet of Langerhans regenerating protein 3; Lithostathine 3; Pancreatitis-associated protein 2; REG 3; REG-3-alpha; Reg III-alpha; RegIII; Regenerating islet-derived protein III-alpha", "protein_names_refseq": "REG 3; REG-3-alpha; islet of Langerhans regenerating protein 3; lithostathine 3; pancreatitis-associated protein 2; reg III-alpha; regIII; regenerating islet-derived protein 3-alpha precursor; regenerating islet-derived protein 3-alpha; regenerating islet-derived protein III-alpha", "tax_id": 10116, "disease": "acute pancreatitis (Disease Ontology:DOID:2913); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:171162); (R-RNO-6803157)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "15100001;18437087;18641332;23303201;23370676;24465846;28415799;8039722;8369291", "class_list": "", "function": "Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation., [UniProtKB, UniProtKB]; After duodenal-jejunal bypass, the level of Reg3alpha and -3beta were not changed in bypassed duodenum in morbidly obese Zucker fatty rats., [RefSeq, PubMed]; Alox15 mRNA levels were 4 times higher in iron-deficient than in iron-adequate pancreas and that Reg1a, Reg3a, and Reg3b mRNA levels were 17-36 times higher in iron-overloaded pancreas. Publication Status: Online-Only, [RefSeq, PubMed]; Bactericidal C-type lectin. The lack of the EPN motif may explain its inability to bind peptidoglycan., [UniProtKB, UniProtKB]; Findings suggest that islet neogenesis-associated protein (INGAP) exerts a positive modulatory effect on beta-cell mass and its secretory function in fetal and neonatal rats, thus becoming a new component in the multifactorial regulation of such processes., [RefSeq, PubMed]; Pancreatitis-associated protein 2 stimulates macrophage activity and likely modulates the inflammatory environment of pancreatitis, [RefSeq, PubMed]; Small interfering RNA-mediated gene knockdown of PAP worsens pancreatitis. Differences in gene knockdown technology may provide different approaches to study gene function., [RefSeq, PubMed]; The pancreas reacts to remote lesions and septic insults in mice and rats with increased PSP synthesis, while PAP is selectively responsive to septic events. Furthermore, our results suggest that serum PSP in septic patients is predominantly derived through an acute phase response of the pancreas., [RefSeq, PubMed]; There is a tight spatial and temporal association between pre-inflammatory changes or inflammation and PAP-expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0008284 positive regulation of cell population proliferation;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006953 acute-phase response;GO:0090303 positive regulation of wound healing", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P35231-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43114-1", "uniprot_id": [ { "id": "PE2R4_RAT", "url": "https://www.uniprot.org/uniprot/P43114", "type": "external" } ], "mass": 53366.0, "length": 488, "protein_name": "Prostaglandin E2 receptor EP4 subtype", "gene_name": "Ptger4", "organism": "Rat", "refseq_name": "prostaglandin E2 receptor EP4 subtype", "refseq_ac": [ { "id": "NP_114465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114465", "type": "external" } ], "gene_names_uniprotkb": "Ptger4", "gene_names_refseq": "EP4; Ptger4; Ptgerep4; Ptger", "protein_names_uniprotkb": "Prostaglandin E2 receptor EP4 subtype; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostanoid EP4 receptor", "protein_names_refseq": "PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostaglandin E2 receptor EP4 subtype; prostaglandin E2 receptor type 4; prostanoid EP4 receptor", "tax_id": 10116, "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); osteoporosis (Disease Ontology:DOID:11476); retinal ischemia (Disease Ontology:DOID:12510); dilated cardiomyopathy (Disease Ontology:DOID:12930); cystitis (Disease Ontology:DOID:1679); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); acute kidney failure (Disease Ontology:DOID:3021); aortic aneurysm (Disease Ontology:DOID:3627); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (rno:84023); (R-RNO-391908)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "31455205;32094439;32165825;34003864;36889213;8185583;9537820", "class_list": "", "function": "A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-kappaB/COX-2 pathway with amplification by IL-1beta and the EP4 receptor. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Role of COX-2/PGE2 signaling pathway in the apoptosis of rat ovarian granulosa cells induced by MEHP., [RefSeq, PubMed]; Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina. Publication Status: Online-Only, [RefSeq, PubMed]; This work has generated a set of novel homology models of the rEP4 and hEP4 receptors. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O08728", "ec_number_list": [], "go_molecular_function": "GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0043025 neuronal cell body;GO:0044306 neuron projection terminus", "go_biological_process": "GO:0033624 negative regulation of integrin activation;GO:2000386 positive regulation of ovarian follicle development;GO:0042466 chemokinesis;GO:1904336 negative regulation of ductus arteriosus closure;GO:1904364 positive regulation of calcitonin secretion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P43114-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499U6-1", "uniprot_id": [ { "id": "NSE1_RAT", "url": "https://www.uniprot.org/uniprot/Q499U6", "type": "external" } ], "mass": 30702.0, "length": 266, "protein_name": "Non-structural maintenance of chromosomes element 1 homolog", "gene_name": "Nsmce1", "organism": "Rat", "refseq_name": "non-structural maintenance of chromosomes element 1 homolog isoform 3", "refseq_ac": [ { "id": "NP_001034700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034700", "type": "external" } ], "gene_names_uniprotkb": "Nsmce1", "gene_names_refseq": "Nsmce1; RGD1307760", "protein_names_uniprotkb": "Non-structural maintenance of chromosomes element 1 homolog; 2.3.2.27; Non-SMC element 1 homolog", "protein_names_refseq": "NSE1 homolog, SMC5-SMC6 complex component; non-SMC element 1 homolog; non-structural maintenance of chromosomes element 1 homolog isoform 3; non-structural maintenance of chromosomes element 1 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:361645); (R-RNO-3108214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046983 protein dimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000775 chromosome, centromeric region;GO:0097431 mitotic spindle pole;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination;GO:0006281 DNA repair;GO:0006310 DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q499U6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02783-1", "uniprot_id": [ { "id": "SVS4_RAT", "url": "https://www.uniprot.org/uniprot/P02783", "type": "external" } ], "mass": 12046.0, "length": 112, "protein_name": "Seminal vesicle secretory protein 4", "gene_name": "Svs4", "organism": "Rat", "refseq_name": "seminal vesicle secretory protein 4 precursor", "refseq_ac": [ { "id": "NP_036794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036794", "type": "external" } ], "gene_names_uniprotkb": "Svs4; Svp2; Svp4", "gene_names_refseq": "ADP; RNSVSP4U; SVS IV; SVSIV1; Svp4; Svs4", "protein_names_uniprotkb": "Seminal vesicle secretory protein 4; ADP; Androgen-dependent protein; SVS IV; SVS protein S; Seminal vesicle protein 2; Seminal vesicle secretory protein IV", "protein_names_refseq": "SVS protein S; Seminal vesicle protein-4; androgen-dependent protein; seminal vesicle protein 2; seminal vesicle protein 4; seminal vesicle secretory protein 4 precursor; seminal vesicle secretory protein IV", "tax_id": 10116, "disease": "cerebral folate receptor alpha deficiency (Disease Ontology:DOID:0050719)", "pathway": " (rno:24802)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17458892;18215165;18243331;18616464;19851073;6164983;6304626;6548962;6579532;7007263", "class_list": "", "function": "Data strongly suggest that SV-IV needs large plasticity to efficiently interact with the different targets that characterize its multifaceted biological function, and should therefore be better classified as an intrinsically disordered protein., [RefSeq, PubMed]; Findings indicate that seminal vesicle protein IV has a marked in vitro inhibitory effect on natural killer cell, lymphokine-activated killer cell and cytotoxic T lymphocyte cytotoxicity, [RefSeq, PubMed]; Induces histamine release from human FcepsilonRI+ cells, [RefSeq, PubMed]; Native seminal vesicle protein 4 was shown by spectrophotometric and electrospray-MS analysis to interact with NADPH, an electron donor substrate of the selenium-dependent glutathione peroxidase/glutathione reductase redox system, [RefSeq, PubMed]; Seminal vesicle protein 4 act as a cell survival factor, preventing apoptosis but not cell cycle arrest. May be involved in survival of implanting embryos., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64713", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P02783-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83006-1", "uniprot_id": [ { "id": "PAFA2_RAT", "url": "https://www.uniprot.org/uniprot/P83006", "type": "external" } ], "mass": 43492.0, "length": 390, "protein_name": "Platelet-activating factor acetylhydrolase 2, cytoplasmic", "gene_name": "Pafah2", "organism": "Rat", "refseq_name": "platelet-activating factor acetylhydrolase 2, cytoplasmic", "refseq_ac": [ { "id": "NP_808793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808793", "type": "external" } ], "gene_names_uniprotkb": "Pafah2", "gene_names_refseq": "Pafah2", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase 2, cytoplasmic; 2.3.1.149; 3.1.1.47; PAF:lysophospholipid transacetylase; PAF:sphingosine transacetylase; Platelet-activating factor acetyltransferase PAFAH2; SD-PLA2; Serine-dependent phospholipase A2", "protein_names_refseq": "PAF:lysophospholipid transacetylase; PAF:sphingosine transacetylase; SD-PLA2; platelet-activating factor acetylhydrolase 2, 40kDa; platelet-activating factor acetylhydrolase 2, cytoplasmic; platelet-activating factor acetyltransferase PAFAH2; serine-dependent phospholipase A2", "tax_id": 10116, "disease": "", "pathway": " (rno:313611); (R-RNO-418346)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10085103", "class_list": "", "function": "Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:10085103). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively (PubMed:10085103). Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (PubMed:10085103)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q80Z89", "ec_number_list": [ { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" } ], "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83006-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33578-1", "uniprot_id": [ { "id": "PR8A7_RAT", "url": "https://www.uniprot.org/uniprot/P33578", "type": "external" } ], "mass": 27270.0, "length": 240, "protein_name": "Prolactin-8A7", "gene_name": "Prl8a7", "organism": "Rat", "refseq_name": "prolactin-8A7 precursor", "refseq_ac": [ { "id": "NP_071982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071982", "type": "external" } ], "gene_names_uniprotkb": "Prl8a7; Prlpd", "gene_names_refseq": "Ghd10; Prl8a7; Prlpd", "protein_names_uniprotkb": "Prolactin-8A7; Growth hormone-related protein 1; PLP-D; PRL-like protein D; Placental prolactin-like protein D", "protein_names_refseq": "PLP-D; PRL-like protein D; growth hormone d10; growth hormone-related protein 1; placental prolactin-like protein D; prolactin-8A7 precursor; prolactin-8A7", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); impulse control disorder (Disease Ontology:DOID:10937); depressive disorder (Disease Ontology:DOID:1596); severe acute respiratory syndrome (Disease Ontology:DOID:2945); carotid artery disease (Disease Ontology:DOID:3407); prolactinoma (Disease Ontology:DOID:5394); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:64368)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2351117;8756556", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P97786;Q4FZY5", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P33578-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88761-1", "uniprot_id": [ { "id": "PSMD1_RAT", "url": "https://www.uniprot.org/uniprot/O88761", "type": "external" } ], "mass": 105748.0, "length": 953, "protein_name": "26S proteasome non-ATPase regulatory subunit 1", "gene_name": "Psmd1", "organism": "Rat", "refseq_name": "26S proteasome non-ATPase regulatory subunit 1", "refseq_ac": [ { "id": "NP_114184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114184", "type": "external" } ], "gene_names_uniprotkb": "Psmd1", "gene_names_refseq": "Psmd1", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 1; 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 1; 26S proteasome p112 subunit; 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome, subunit p112; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1", "tax_id": 10116, "disease": "", "pathway": " (rno:83806); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-6798695); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 57, "publication_count": 3, "publication_id_list": "16112871;17975104;22673903", "class_list": "", "function": "Analysis of proteasome 19 and 26 dysfunction after brain ischemia, [RefSeq, PubMed]; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Proteasome inhibition exerts an acute pro-survival action by stabilizing transcription factors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0042176 regulation of protein catabolic process;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88761-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C6B3-1", "uniprot_id": [ { "id": "PTCRA_RAT", "url": "https://www.uniprot.org/uniprot/P0C6B3", "type": "external" } ], "mass": 21340.0, "length": 199, "protein_name": "Pre T-cell antigen receptor alpha", "gene_name": "Ptcra", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptcra", "gene_names_refseq": "", "protein_names_uniprotkb": "Pre T-cell antigen receptor alpha; pT-alpha-TCR; pT-alpha; pTa", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:116462)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11169403", "class_list": "", "function": "Component of the pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) that has a crucial role in early T-cell development, particularly alpha-beta T cell differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0070244 negative regulation of thymocyte apoptotic process;GO:0046632 alpha-beta T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C6B3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51974-1", "uniprot_id": [ { "id": "PAX8_RAT", "url": "https://www.uniprot.org/uniprot/P51974", "type": "external" } ], "mass": 48806.0, "length": 457, "protein_name": "Paired box protein Pax-8", "gene_name": "Pax8", "organism": "Rat", "refseq_name": "paired box protein Pax-8 isoform 1", "refseq_ac": [ { "id": "NP_112403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112403", "type": "external" } ], "gene_names_uniprotkb": "Pax8; Pax-8", "gene_names_refseq": "Pax8", "protein_names_uniprotkb": "Paired box protein Pax-8", "protein_names_refseq": "Pax-8 protein; paired box gene 8; paired box protein Pax-8 isoform 1; paired box protein Pax-8", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); congenital nongoitrous hypothyroidism 2 (Disease Ontology:DOID:0070124)", "pathway": " (rno:81819)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23868062;25270402;26030152;27780871;34726504", "class_list": "", "function": "A Critical Balance Between PAX8 and the Hippo Mediator TAZ Determines Sodium/Iodide Symporter Expression and Function., [RefSeq, PubMed]; Pax8 controls apical-basal follicular polarization and follicle formation through Cdh16., [RefSeq, PubMed]; Pax8 is required for the survival of differentiated epithelial cells and its expression levels are able to modulate the proliferation rate of such cells. Publication Status: Online-Only, [RefSeq, PubMed]; The 5'-flanking region of the Wnt4 gene is responsive to Pax8. Pax8 modulates the expression of Wnt4 in thyroid cells. Publication Status: Online-Only, [RefSeq, PubMed]; The novel interplay between PAX8 and Neuropilin-2 Publication Status: Online-Only, [RefSeq, PubMed]; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q66HM8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0030878 thyroid gland development;GO:2000612 regulation of thyroid-stimulating hormone secretion;GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation;GO:0039003 pronephric field specification;GO:0072207 metanephric epithelium development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P51974-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62138-1", "uniprot_id": [ { "id": "PP1A_RAT", "url": "https://www.uniprot.org/uniprot/P62138", "type": "external" } ], "mass": 37512.0, "length": 330, "protein_name": "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "gene_name": "Ppp1ca", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "refseq_ac": [ { "id": "NP_113715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113715", "type": "external" } ], "gene_names_uniprotkb": "Ppp1ca; Ppp1a", "gene_names_refseq": "PP1alpha; Ppp1ca", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; 3.1.3.16; PP-1A", "protein_names_refseq": "PP-1A; Protein phosphatase type 1 alpha, catalytic subunit; protein phosphatase 1, catalytic subunit, alpha isozyme; protein phosphatase-1d; serine/threonine-protein phosphatase PP1-alpha catalytic subunit", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24668); (R-RNO-180024); (R-RNO-9770562)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10504266;16387841;1650776;17890166;2177460;22494112;24116158;29383693;7751917", "class_list": "", "function": "Data indicate that the protein phosphatase 1 (PP1) and nuclear membrane protein lamina associated polypeptide 1B (LAP1B) LAP1B:PP1 complex can be immunoprecipitated from cerebral cortex. Publication Status: Online-Only, [RefSeq, PubMed]; PP1 bound on spinophilin, a close homolog of neurabin and another major synaptic PP1 anchoring protein, does not play a role in long term depression [LTD] induction, which suggests that neurabin plays a privileged role in nanodomain targeting of PP1 in LTD induction., [RefSeq, PubMed]; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H. The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription. PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation. PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (By similarity). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy. Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P08129;P20653;P22802", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0043021 ribonucleoprotein complex binding;GO:0046914 transition metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0005981 regulation of glycogen catabolic process;GO:0043247 telomere maintenance in response to DNA damage;GO:0010288 response to lead ion;GO:0051301 cell division;GO:0005977 glycogen metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P62138-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60901-1", "uniprot_id": [ { "id": "PSA6_RAT", "url": "https://www.uniprot.org/uniprot/P60901", "type": "external" } ], "mass": 27399.0, "length": 246, "protein_name": "Proteasome subunit alpha type-6", "gene_name": "Psma6", "organism": "Rat", "refseq_name": "proteasome subunit alpha type-6", "refseq_ac": [ { "id": "NP_058979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058979", "type": "external" } ], "gene_names_uniprotkb": "Psma6", "gene_names_refseq": "Psma6", "protein_names_uniprotkb": "Proteasome subunit alpha type-6; Macropain iota chain; Multicatalytic endopeptidase complex iota chain; Proteasome iota chain; Proteasome subunit alpha-1; alpha-1", "protein_names_refseq": "alpha-1; macropain iota chain; multicatalytic endopeptidase complex iota chain; proteasome (prosome, macropain) subunit, alpha type 6; proteasome alpha 6 subunit; proteasome iota chain; proteasome subunit alpha 6; proteasome subunit alpha type-6; proteasome subunit alpha-1", "tax_id": 10116, "disease": "myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:29673); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 58, "publication_count": 3, "publication_id_list": "1491007;30287505;34502162", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PSMA6 mRNA is post-transcriptionally regulated by miRNA-4490, whose expression is inversely correlated to PSMA6 protein expression. Erratum:[Biosci Rep. 2019 Jan 11;39(1):BSR-20180815_COR. doi: 10.1042/BSR-20180815_COR. PMID: 30635449] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P34062", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0051059 NF-kappaB binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050727 regulation of inflammatory response;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P60901-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499U1-1", "uniprot_id": [ { "id": "S2538_RAT", "url": "https://www.uniprot.org/uniprot/Q499U1", "type": "external" } ], "mass": 35230.0, "length": 326, "protein_name": "Mitochondrial glycine transporter", "gene_name": "Slc25a38", "organism": "Rat", "refseq_name": "mitochondrial glycine transporter", "refseq_ac": [ { "id": "NP_001025203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025203", "type": "external" } ], "gene_names_uniprotkb": "Slc25a38; SLC25A38", "gene_names_refseq": "RGD1311914; Slc25a38", "protein_names_uniprotkb": "Mitochondrial glycine transporter; Solute carrier family 25 member 38", "protein_names_refseq": "mitochondrial glycine transporter", "tax_id": 10116, "disease": "autosomal recessive pyridoxine-refractory sideroblastic anemia 2 (Disease Ontology:DOID:0060065); sideroblastic anemia (Disease Ontology:DOID:8955)", "pathway": " (rno:301067)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis., [UniProtKB, HAMAP, UniProtKB, UniProtKB]; Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "G3V8E7", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0030218 erythrocyte differentiation;GO:1904983 glycine import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499U1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31646-1", "uniprot_id": [ { "id": "S6A13_RAT", "url": "https://www.uniprot.org/uniprot/P31646", "type": "external" } ], "mass": 68263.0, "length": 602, "protein_name": "Sodium- and chloride-dependent GABA transporter 2", "gene_name": "Slc6a13", "organism": "Rat", "refseq_name": "sodium- and chloride-dependent GABA transporter 2 isoform 1", "refseq_ac": [ { "id": "NP_598307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598307", "type": "external" } ], "gene_names_uniprotkb": "Slc6a13; Gabt2; Gat-2", "gene_names_refseq": "GAT-2; Slc6a13", "protein_names_uniprotkb": "Sodium- and chloride-dependent GABA transporter 2; GAT-2; Solute carrier family 6 member 13", "protein_names_refseq": "sodium- and chloride-dependent GABA transporter 2 isoform 1; sodium- and chloride-dependent GABA transporter 2; solute carrier family 6 (neurotransmitter transporter), member 13; solute carrier family 6 (neurotransmitter transporter, GABA), member 13", "tax_id": 10116, "disease": "", "pathway": " (rno:171163); (R-RNO-442660); (R-RNO-888593)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "12107427;1400419;21997971;22384273;22678999;22896705", "class_list": "", "function": "GAT2 makes a major contribution to the sinusoidal GAA uptake by periportal hepatocytes, thus regulating creatine biosynthesis in the liver, [RefSeq, PubMed]; Large number of GAT2-immunoreactive structures that surrounded neurons within each ganglion of the myenteric plexus., [RefSeq, PubMed]; Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:1400419, PubMed:22896705). Mediates transport of taurine and is the major taurine transporter in hepatocytes (PubMed:22896705). Can also mediate transport of beta-alanine and hypotaurine (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; RGat2-mediated d(3)-GBB uptake was Na(+) and Cl(-) dependent., [RefSeq, PubMed]; Results suggest that GAT2 is responsible for taurine transport from the circulating blood to hepatocytes predominantly in the periportal region., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0016597 amino acid binding;GO:0015171 amino acid transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity;GO:0005369 taurine:sodium symporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0042995 cell projection", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0015734 taurine transmembrane transport;GO:0015881 creatine transmembrane transport;GO:0051939 gamma-aminobutyric acid import", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P31646-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49797-1", "uniprot_id": [ { "id": "RGS3_RAT", "url": "https://www.uniprot.org/uniprot/P49797", "type": "external" } ], "mass": 106380.0, "length": 967, "protein_name": "Regulator of G protein signaling 3", "gene_name": "Rgs3", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 3 isoform 2", "refseq_ac": [ { "id": "NP_062213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062213", "type": "external" } ], "gene_names_uniprotkb": "Rgs3", "gene_names_refseq": "Rgs3; SRB-RGS", "protein_names_uniprotkb": "Regulator of G protein signaling 3; RGS3; SRB-RGS", "protein_names_refseq": "regulator of G-protein signaling 3 isoform 2; regulator of G-protein signalling 3", "tax_id": 10116, "disease": "lesion of sciatic nerve (Disease Ontology:DOID:12528); bladder disease (Disease Ontology:DOID:365)", "pathway": " (rno:54293); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10702309;11595167;12006602;12062898;14550772;17541154;22673903;8548815", "class_list": "", "function": "Cell surface expression and regulation of GnRHR bearing a carboxyl-terminus is altered by RGS10, but not by RGS3, proteins, [RefSeq, PubMed]; Down-regulates signaling from heterotrimeric G proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G protein-mediated release of inositol phosphates and activation of MAP kinases., [UniProtKB]; Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RGS3 is expressed at high levels in C-fiber primary sensory neurons in the adult rat dorsal root ganglion (DRG) and sciatic nerve transection results in a downregulation of this transcript., [RefSeq, PubMed]; Role in regulating mitogen-activated protein kinase activation in rat vascular smooth muscle cells, [RefSeq, PubMed]; SRB-RGS was characterized and identified as a steroid receptor-binding protein., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5RKK6;Q920Q9", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P49797-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B8N7-1", "uniprot_id": [ { "id": "T22D4_RAT", "url": "https://www.uniprot.org/uniprot/Q3B8N7", "type": "external" } ], "mass": 40041.0, "length": 387, "protein_name": "TSC22 domain family protein 4", "gene_name": "Ppp1r35; Spacdr; Tsc22d4", "organism": "Rat", "refseq_name": "TSC22 domain family protein 4", "refseq_ac": [ { "id": "NP_001037749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037749", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r35; Spacdr; Tsc22d4; C12H7orf61; Spacdr; Thg1-pit; Tsc22d4", "gene_names_refseq": "Spacdr; Tilz2; Tsc22d4; thg-1pit", "protein_names_uniprotkb": "TSC22 domain family protein 4; TSC22-related-inducible leucine zipper protein 2", "protein_names_refseq": "TSC22 domain family protein 4; TSC22-related-inducible leucine zipper protein 2; sperm acrosome developmental regulator; uncharacterized protein C7orf61 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:684980); (rno:684993)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Binds DNA and acts as a transcriptional repressor (By similarity). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (By similarity). May play a role in neurite elongation and survival (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0045202 synapse;GO:0005813 centrosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006970 response to osmotic stress;GO:0070050 neuron cellular homeostasis;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3B8N7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14882-1", "uniprot_id": [ { "id": "PCCA_RAT", "url": "https://www.uniprot.org/uniprot/P14882", "type": "external" } ], "mass": 81623.0, "length": 737, "protein_name": "Propionyl-CoA carboxylase alpha chain, mitochondrial", "gene_name": "Pcca", "organism": "Rat", "refseq_name": "propionyl-CoA carboxylase alpha chain, mitochondrial", "refseq_ac": [ { "id": "NP_062203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062203", "type": "external" } ], "gene_names_uniprotkb": "Pcca", "gene_names_refseq": "Pcca", "protein_names_uniprotkb": "Propionyl-CoA carboxylase alpha chain, mitochondrial; 6.4.1.3; PCCase subunit alpha; Propanoyl-CoA:carbon dioxide ligase subunit alpha", "protein_names_refseq": "PCCase alpha subunit; PCCase subunit alpha; Propionyl Coenzyme A carboxylase alpha polypeptide; propanoyl-CoA:carbon dioxide ligase alpha subunit; propanoyl-CoA:carbon dioxide ligase subunit alpha; propionyl CoA carboxylase, alpha polypeptide; propionyl-CoA carboxylase alpha chain, mitochondrial; propionyl-CoA carboxylase alpha subunit; propionyl-coenzyme A carboxylase, alpha polypeptide", "tax_id": 10116, "disease": "propionic acidemia (Disease Ontology:DOID:14701); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:687008); (R-RNO-196780); (R-RNO-71032)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15060005;19699272;22673903;26446791;27213235;2745462;34502162", "class_list": "", "function": "Methylmalonyl-CoA mutase and PCCA show a much higher expression level in the entire CNS than in the liver, suggesting a different, but important function of this pathway during brain development., [RefSeq, PubMed]; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" }, { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0004658 propionyl-CoA carboxylase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:1902494 catalytic complex", "go_biological_process": "GO:0009062 fatty acid catabolic process;GO:0009063 amino acid catabolic process;GO:1901290 succinyl-CoA biosynthetic process;GO:0016042 lipid catabolic process;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P14882-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05710-1", "uniprot_id": [ { "id": "PRLR_RAT", "url": "https://www.uniprot.org/uniprot/P05710", "type": "external" } ], "mass": 68599.0, "length": 610, "protein_name": "Prolactin receptor", "gene_name": "Prlr", "organism": "Rat", "refseq_name": "prolactin receptor isoform b precursor", "refseq_ac": [ { "id": "NP_036762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036762", "type": "external" } ], "gene_names_uniprotkb": "Prlr; PRLR", "gene_names_refseq": "Prlr; RATPRLR", "protein_names_uniprotkb": "Prolactin receptor; Lactogen receptor; PRL-R", "protein_names_refseq": "PRL-R; lactogen receptor; prolactin receptor isoform b precursor", "tax_id": 10116, "disease": "familial medullary thyroid carcinoma (Disease Ontology:DOID:0050547); hyperprolactinemia (Disease Ontology:DOID:12700)", "pathway": " (rno:24684); (R-RNO-1170546); (R-RNO-982772)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10395247;10966654;1718958;17675186;2159291;2293022;24114406;25446202;26874070;2832068;30500398;7929319", "class_list": "", "function": "PRLR signaling is required for DNA synthesis and survival of rat insulinoma cells, [RefSeq, PubMed]; Results showed that an active sexual life, with constant execution of sexual behavior, produces a sustained increase in serum PRL, prostate PRL receptors, and the pStat3 signaling pathway, [RefSeq, PubMed]; Study indicates that chronic prolactin administration before kainic acid induced damage induces hippocampal neuroprotection associated with prolactin receptor and VGLUT1 overexpression., [RefSeq, PubMed]; This is a receptor for the anterior pituitary hormone prolactin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study demonstrated that the Cultured neurons expressed mRNA for both PRL and its receptor (PRLR), and both PRL and PRLR expression levels changed after the excitotoxic insult., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 1, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q62832;Q63451;Q63479;Q63723;Q64274", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0008289 lipid binding;GO:0017046 peptide hormone binding;GO:0019955 cytokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity;GO:0008284 positive regulation of cell population proliferation;GO:0030155 regulation of cell adhesion;GO:0043066 negative regulation of apoptotic process;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P05710-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000100010000.011.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20646-1", "uniprot_id": [ { "id": "PPAP_RAT", "url": "https://www.uniprot.org/uniprot/P20646", "type": "external" } ], "mass": 43739.0, "length": 381, "protein_name": "Prostatic acid phosphatase", "gene_name": "Acp3", "organism": "Rat", "refseq_name": "prostatic acid phosphatase long isoform precursor", "refseq_ac": [ { "id": "NP_001128373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128373", "type": "external" } ], "gene_names_uniprotkb": "Acp3; Acpp", "gene_names_refseq": "5'-NT; Acp3; Acpp11; Acpp; FRAP; Ppal; RNACPP11; pap", "protein_names_uniprotkb": "Prostatic acid phosphatase; 3.1.3.2; 3.1.3.48; 3.1.3.5; 5'-NT; 5'-nucleotidase; Acid phosphatase 3; Ecto-5'-nucleotidase; FRAP; Fluoride-resistant acid phosphatase; Protein tyrosine phosphatase ACP3; TMPase; Thiamine monophosphatase", "protein_names_refseq": "5'-nucleotidase; TMPase; acid phosphatase, prostate; ecto-5'-nucleotidase; fluoride-resistant acid phosphatase; prostatic acid phosphatase (rPAP); prostatic acid phosphatase long isoform precursor; protein tyrosine phosphatase ACP3; thiamine monophosphatase", "tax_id": 10116, "disease": "Dent disease (Disease Ontology:DOID:0050699); X-linked recessive hypophosphatemic rickets (Disease Ontology:DOID:0080353); Dent disease 1 (Disease Ontology:DOID:0081453); X-linked nephrolithiasis type I (Disease Ontology:DOID:0111798); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); prostate cancer (Disease Ontology:DOID:10283); osteopetrosis (Disease Ontology:DOID:13533); renal tubular transport disease (Disease Ontology:DOID:447)", "pathway": " (rno:56780); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "17638863;20084276;2373368;2421214;25482440;25674224;27348306;8077215;8168503;8334986;8407898", "class_list": "", "function": "A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma., [UniProtKB, PubMed]; Acpp plays an important role in growth and development of the penis of rats, and its expression is modulated at epigenomic levels via specific miRs, [RefSeq, PubMed]; In addition to its tyrosine phosphatase activity, also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP. This extracellular adenosine leads to a decrease in chronic pain by activating A1R in nociceptive neurons., [UniProtKB, UniProtKB]; Our findings suggest that the decrease of PAP in dorsal root ganglion neurons is involved in pathophysiological mechanisms of neuropathic pain Publication Status: Online-Only, [RefSeq, PubMed]; PAP-immunoreactivity was present in type I and one of type III taste cells of taste buds. Thus, it is suggested that PAP might be a responsible ectoenzyme for metabolism of extracellular nucleotides, being involved in the regulation of taste signaling in taste buds. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JSL5;A6XJQ5", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.7.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.77", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" }, { "id": "3.3.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10", "type": "external" }, { "id": "3.1.3.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0033265 choline binding;GO:0052642 lysophosphatidic acid phosphatase activity;GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030141 secretory granule;GO:0045177 apical part of cell", "go_biological_process": "GO:0016311 dephosphorylation;GO:0006629 lipid metabolic process;GO:0009117 nucleotide metabolic process;GO:0046085 adenosine metabolic process;GO:0051930 regulation of sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P20646-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLY3-1", "uniprot_id": [ { "id": "VSIG1_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLY3", "type": "external" } ], "mass": 43938.0, "length": 404, "protein_name": "V-set and immunoglobulin domain-containing protein 1", "gene_name": "Vsig1", "organism": "Rat", "refseq_name": "V-set and immunoglobulin domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001032873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032873", "type": "external" } ], "gene_names_uniprotkb": "Vsig1", "gene_names_refseq": "Vsig1", "protein_names_uniprotkb": "V-set and immunoglobulin domain-containing protein 1", "protein_names_refseq": "V-set and immunoglobulin domain-containing protein 1 precursor; V-set and immunoglobulin domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:315920)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0030277 maintenance of gastrointestinal epithelium;GO:0003382 epithelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLY3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68907-1", "uniprot_id": [ { "id": "PZRN3_RAT", "url": "https://www.uniprot.org/uniprot/P68907", "type": "external" } ], "mass": 119289.0, "length": 1062, "protein_name": "E3 ubiquitin-protein ligase PDZRN3", "gene_name": "Pdzrn3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pdzrn3; Semcap3", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase PDZRN3; 2.3.2.27; PDZ domain-containing RING finger protein 3; Protein SEMACAP3; RING-type E3 ubiquitin transferase PDZRN3; Semaphorin cytoplasmic domain-associated protein 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:312607)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15458844", "class_list": "", "function": "E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031594 neuromuscular junction;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P68907-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q569B7-1", "uniprot_id": [ { "id": "RWDD4_RAT", "url": "https://www.uniprot.org/uniprot/Q569B7", "type": "external" } ], "mass": 21115.0, "length": 188, "protein_name": "RWD domain-containing protein 4", "gene_name": "Rwdd4", "organism": "Rat", "refseq_name": "RWD domain-containing protein 4", "refseq_ac": [ { "id": "NP_001030166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030166", "type": "external" } ], "gene_names_uniprotkb": "Rwdd4; Rwdd4a", "gene_names_refseq": "Rwdd4a; Rwdd4", "protein_names_uniprotkb": "RWD domain-containing protein 4", "protein_names_refseq": "RWD domain containing 4A; RWD domain-containing protein 4; family with sequence similarity 28, member A", "tax_id": 10116, "disease": "", "pathway": " (rno:502084)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q569B7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70257-1", "uniprot_id": [ { "id": "STX7_RAT", "url": "https://www.uniprot.org/uniprot/O70257", "type": "external" } ], "mass": 29851.0, "length": 261, "protein_name": "Syntaxin-7", "gene_name": "Stx7", "organism": "Rat", "refseq_name": "syntaxin-7", "refseq_ac": [ { "id": "NP_068641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068641", "type": "external" } ], "gene_names_uniprotkb": "Stx7", "gene_names_refseq": "Stx7", "protein_names_uniprotkb": "Syntaxin-7", "protein_names_refseq": "syntaxin-7-like; syntaxin-7", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305)", "pathway": " (rno:60466)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11101518;11786915;15133481;29393594;9417091", "class_list": "", "function": "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs, [RefSeq, PubMed]; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U337", "ec_number_list": [], "go_molecular_function": "GO:0019869 chloride channel inhibitor activity;GO:0044877 protein-containing complex binding;GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0043195 terminal bouton;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0008333 endosome to lysosome transport;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0016192 vesicle-mediated transport;GO:1903076 regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O70257-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29288-1", "uniprot_id": [ { "id": "PPA5_RAT", "url": "https://www.uniprot.org/uniprot/P29288", "type": "external" } ], "mass": 36726.0, "length": 327, "protein_name": "Tartrate-resistant acid phosphatase type 5", "gene_name": "Acp5", "organism": "Rat", "refseq_name": "tartrate-resistant acid phosphatase type 5 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001257818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257818", "type": "external" } ], "gene_names_uniprotkb": "Acp5", "gene_names_refseq": "Acp5; TTRRAP; Trap", "protein_names_uniprotkb": "Tartrate-resistant acid phosphatase type 5; 3.1.3.2; TR-AP; Tartrate-resistant acid ATPase; TrATPase; Type 5 acid phosphatase", "protein_names_refseq": "TR-AP; acid phosphatase type V; tartrate-resistant acid ATPase; tartrate-resistant acid phosphatase type 5 isoform 2 precursor; tartrate-resistant acid phosphatase type 5; trATPase; type 5 acid phosphatase", "tax_id": 10116, "disease": "Dent disease (Disease Ontology:DOID:0050699); low molecular weight proteinuria with hypercalciuric nephrocalcinosis (Disease Ontology:DOID:0111815); Raynaud-Claes syndrome (Disease Ontology:DOID:0112060); spondylometaphyseal dysplasia (Disease Ontology:DOID:0112295); osteopetrosis (Disease Ontology:DOID:13533)", "pathway": " (rno:25732); (R-RNO-196843)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10388567;10438611;1722212;1830446;22878484;23868496;24223830;24395179;29393594", "class_list": "", "function": "Data indicate that tartrate-resistant acid phosphatase 5b levels treated with cadmium and fluoride or in combination were 1-2.5 folds higher than the control., [RefSeq, PubMed]; Increased osteoclast activity does not affect TRAP expression in osteoblasts and osteocytes, [RefSeq, PubMed]; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Polyphosphate may play an important regulatory role in osteoclastic bone resorption by inhibiting TRAP activity. Publication Status: Online-Only, [RefSeq, PubMed]; RANKL and OPG expressions were not changed by chronic exposure to fluoride in the drinking water during the studied periods; on the other hand, TRAP expression was changed (at 7 days) by chronic exposure to fluoride, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003993 acid phosphatase activity;GO:0008198 ferrous iron binding;GO:0008199 ferric iron binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0016311 dephosphorylation;GO:0007162 negative regulation of cell adhesion;GO:0010043 response to zinc ion;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P29288-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35815-1", "uniprot_id": [ { "id": "PPM1B_RAT", "url": "https://www.uniprot.org/uniprot/P35815", "type": "external" } ], "mass": 42889.0, "length": 390, "protein_name": "Protein phosphatase 1B", "gene_name": "Ppm1b", "organism": "Rat", "refseq_name": "protein phosphatase 1B isoform 1", "refseq_ac": [ { "id": "NP_149087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_149087", "type": "external" } ], "gene_names_uniprotkb": "Ppm1b; Pp2c2; Pppm1b", "gene_names_refseq": "PP2C-beta; Pp2c2; Ppm1b", "protein_names_uniprotkb": "Protein phosphatase 1B; 3.1.3.16; PP2C-beta; Protein phosphatase 2C isoform beta", "protein_names_refseq": "protein phosphatase 1B isoform 1", "tax_id": 10116, "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); familial erythrocytosis 4 (Disease Ontology:DOID:0080339); pre-eclampsia (Disease Ontology:DOID:10591); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); von Hippel-Lindau disease (Disease Ontology:DOID:14175); cancer (Disease Ontology:DOID:162); acute kidney failure (Disease Ontology:DOID:3021); intermittent claudication (Disease Ontology:DOID:3669); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); polycythemia (Disease Ontology:DOID:8432); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:24667); (R-RNO-1169408)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1312947;7532404", "class_list": "", "function": "Enzyme with a broad specificity. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q546R0;Q64046", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.3.2.n3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction;GO:0006470 protein dephosphorylation;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35815-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07141-1", "uniprot_id": [ { "id": "TLE4_RAT", "url": "https://www.uniprot.org/uniprot/Q07141", "type": "external" } ], "mass": 81334.0, "length": 748, "protein_name": "Transducin-like enhancer protein 4", "gene_name": "Tle4", "organism": "Rat", "refseq_name": "transducin-like enhancer protein 4 isoform 2", "refseq_ac": [ { "id": "NP_062014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062014", "type": "external" } ], "gene_names_uniprotkb": "Tle4; Esp2; Grg4", "gene_names_refseq": "Esp2; Grg-4; Tle4", "protein_names_uniprotkb": "Transducin-like enhancer protein 4; Grg-4; Groucho-related protein 4; Protein ESP2", "protein_names_refseq": "groucho-related protein 4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 4, E(spl) homolog; transducin-like enhancer of split 4, homolog of Drosophila E(spl); transducin-like enhancer protein 4 isoform 2; transducin-like enhancer protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:25565); (R-RNO-201722); (R-RNO-3769402); (R-RNO-4641265)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "15340146;18254933;22673903;38791273;8245004", "class_list": "", "function": "Sox10 Activity and the Timing of Schwann Cell Differentiation Are Controlled by a Tle4-Dependent Negative Feedback Loop. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q07141-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70489-1", "uniprot_id": [ { "id": "PPT2_RAT", "url": "https://www.uniprot.org/uniprot/O70489", "type": "external" } ], "mass": 34355.0, "length": 302, "protein_name": "Lysosomal thioesterase PPT2", "gene_name": "Ppt2", "organism": "Rat", "refseq_name": "lysosomal thioesterase PPT2 precursor", "refseq_ac": [ { "id": "NP_062240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062240", "type": "external" } ], "gene_names_uniprotkb": "Ppt2", "gene_names_refseq": "Ppt2", "protein_names_uniprotkb": "Lysosomal thioesterase PPT2; 3.1.2.2; PPT-2", "protein_names_refseq": "lysosomal thioesterase PPT2 precursor; lysosomal thioesterase PPT2", "tax_id": 10116, "disease": "neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503)", "pathway": " (rno:54398); (R-RNO-75105)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "Catalyzes the cleavage of thioester bonds from S-palmitoyl-CoA or S-palmitoyl-N-acetylcysteamine (unbranched structures) but does not have activity against palmitoylcysteine or palmitoylated proteins, branched structures or bulky head groups. Conversely, hydrolyzes both long and short chain fatty acyl-CoA substrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O88500", "ec_number_list": [ { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" } ], "go_molecular_function": "GO:0047617 fatty acyl-CoA hydrolase activity;GO:0016790 thiolester hydrolase activity;GO:0098599 palmitoyl hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O70489-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07066-1", "uniprot_id": [ { "id": "PXMP2_RAT", "url": "https://www.uniprot.org/uniprot/Q07066", "type": "external" } ], "mass": 22577.0, "length": 194, "protein_name": "Peroxisomal membrane protein 2", "gene_name": "Pxmp2", "organism": "Rat", "refseq_name": "peroxisomal membrane protein 2", "refseq_ac": [ { "id": "NP_113775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113775", "type": "external" } ], "gene_names_uniprotkb": "Pxmp2; Pmp22", "gene_names_refseq": "PMP 22; Pxmp2; T44", "protein_names_uniprotkb": "Peroxisomal membrane protein 2; 22 kDa peroxisomal membrane protein", "protein_names_refseq": "22 kDa peroxisomal membrane protein; liver regeneration-related protein LRRG01; peroxisomal membrane protein 2, 22 kDa; peroxisomal membrane protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:29533); (R-RNO-9603798)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "18984054;8422909", "class_list": "", "function": "Overexcpression and puification of Pxmp2 in Pichia are reported., [RefSeq, PubMed]; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0032991 protein-containing complex;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q07066-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR82-1", "uniprot_id": [ { "id": "S39A9_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR82", "type": "external" } ], "mass": 30177.0, "length": 287, "protein_name": "Zinc transporter ZIP9", "gene_name": "Slc39a9", "organism": "Rat", "refseq_name": "zinc transporter ZIP9 isoform 2", "refseq_ac": [ { "id": "NP_001030101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030101", "type": "external" } ], "gene_names_uniprotkb": "Slc39a9; Zip9", "gene_names_refseq": "Slc39a9", "protein_names_uniprotkb": "Zinc transporter ZIP9; Solute carrier family 39 member 9; ZIP-9; Zrt- and Irt-like protein 9", "protein_names_refseq": "ZIP-9; solute carrier family 39 (zinc transporter), member 9; zinc transporter ZIP9 isoform 2; zinc transporter ZIP9; zrt- and Irt-like protein 9", "tax_id": 10116, "disease": "", "pathway": " (rno:314275)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "27164415;35625396", "class_list": "", "function": "In Sertoli cells, testosterone acts through the receptor ZIP9 to trigger the non-classical signaling cascade, resulting in increased claudin expression and tight junction formation., [RefSeq, PubMed]; Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0004930 G protein-coupled receptor activity;GO:0005497 androgen binding;GO:0022883 zinc efflux transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0070830 bicellular tight junction assembly;GO:0006882 intracellular zinc ion homeostasis;GO:1905562 regulation of vascular endothelial cell proliferation;GO:2000654 regulation of cellular response to testosterone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3KR82-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q566D0-1", "uniprot_id": [ { "id": "UPK1B_RAT", "url": "https://www.uniprot.org/uniprot/Q566D0", "type": "external" } ], "mass": 29813.0, "length": 260, "protein_name": "Uroplakin-1b", "gene_name": "Upk1b", "organism": "Rat", "refseq_name": "uroplakin-1b", "refseq_ac": [ { "id": "NP_001019424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019424", "type": "external" } ], "gene_names_uniprotkb": "Upk1b", "gene_names_refseq": "UP1b; UPIb; Upk1b", "protein_names_uniprotkb": "Uroplakin-1b; UP1b; UPIb; Uroplakin Ib", "protein_names_refseq": "uroplakin Ib; uroplakin-1b", "tax_id": 10116, "disease": "", "pathway": " (rno:303924)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21301865", "class_list": "", "function": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; During urothelial carcinogenesis, UPII expression was the most decreased in all urothelial lesions, while UPIa, UPIb, and UPIIIa expression was differently altered in different types of lesions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0120001 apical plasma membrane urothelial plaque;GO:0016324 apical plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q566D0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13086-1", "uniprot_id": [ { "id": "SUCA_RAT", "url": "https://www.uniprot.org/uniprot/P13086", "type": "external" } ], "mass": 36148.0, "length": 346, "protein_name": "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial", "gene_name": "Suclg1", "organism": "Rat", "refseq_name": "succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor", "refseq_ac": [ { "id": "NP_446204", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446204", "type": "external" } ], "gene_names_uniprotkb": "Suclg1; SUCLG1", "gene_names_refseq": "Suclg1", "protein_names_uniprotkb": "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; 6.2.1.-; 6.2.1.4; 6.2.1.5; 6.2.1.9; Itaconyl--CoA ligase [ADP/GDP-forming] subunit alpha; Malyl--CoA ligase [ADP/GDP-forming] subunit alpha; SCS-alpha; Succinyl-CoA synthetase subunit alpha", "protein_names_refseq": "SCS-alpha; itaconyl--CoA ligase [ADP/GDP-forming] subunit alpha; malyl--CoA ligase [ADP/GDP-forming] subunit alpha; succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor; succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; succinate-CoA ligase, GDP-forming alpha subunit; succinate-CoA ligase, alpha subunit; succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial; succinyl-CoA synthetase alpha subunit; succinyl-CoA synthetase subunit alpha", "tax_id": 10116, "disease": "mitochondrial DNA depletion syndrome 9 (Disease Ontology:DOID:0080128)", "pathway": " (rno:114597); (R-RNO-71403)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17403370;3422742;38843836", "class_list": "", "function": "In INS-1 832/13 cells and cultured rat islets, siRNA suppression of the GTP-producing pathway reduced glucose-stimulated insulin secretion by 50%., [RefSeq, PubMed]; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Also able to act as an itaconyl- and malyl-CoA synthetase., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P7S4", "ec_number_list": [ { "id": "6.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.9", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0019003 GDP binding;GO:0004775 succinate-CoA ligase (ADP-forming) activity;GO:0004776 succinate-CoA ligase (GDP-forming) activity;GO:0004774 succinate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0032991 protein-containing complex;GO:1902494 catalytic complex;GO:0045244 succinate-CoA ligase complex (GDP-forming)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006104 succinyl-CoA metabolic process;GO:0006105 succinate metabolic process;GO:0006108 malate metabolic process;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P13086-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KM49-1", "uniprot_id": [ { "id": "SYYC_RAT", "url": "https://www.uniprot.org/uniprot/Q4KM49", "type": "external" } ], "mass": 59115.0, "length": 528, "protein_name": "Tyrosine--tRNA ligase, cytoplasmic", "gene_name": "Yars1", "organism": "Rat", "refseq_name": "tyrosine--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_001020867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020867", "type": "external" } ], "gene_names_uniprotkb": "Yars1; Yars", "gene_names_refseq": "Yars1; Yars", "protein_names_uniprotkb": "Tyrosine--tRNA ligase, cytoplasmic; 6.1.1.1; TyrRS; Tyrosyl-tRNA synthetase", "protein_names_refseq": "tyrRS; tyrosine--tRNA ligase, cytoplasmic; tyrosyl--tRNA ligase; tyrosyl-tRNA synthetase, cytoplasmic", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease dominant intermediate C (Disease Ontology:DOID:0110199); multisystem proteinopathy (Disease Ontology:DOID:070355); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); cancer (Disease Ontology:DOID:162); neuropathy (Disease Ontology:DOID:870)", "pathway": " (rno:313047)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29289698", "class_list": "", "function": "Conclusion is further supported by a positive correlation across brain regions between TyrRS expression and arginine-accelerated KTP production., [RefSeq, PubMed]; Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0036094 small molecule binding;GO:0004831 tyrosine-tRNA ligase activity;GO:0004812 aminoacyl-tRNA ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0042594 response to starvation;GO:0006437 tyrosyl-tRNA aminoacylation;GO:0006418 tRNA aminoacylation for protein translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KM49-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23680-1", "uniprot_id": [ { "id": "SAMP_RAT", "url": "https://www.uniprot.org/uniprot/P23680", "type": "external" } ], "mass": 26176.0, "length": 228, "protein_name": "Serum amyloid P-component", "gene_name": "Apcs", "organism": "Rat", "refseq_name": "serum amyloid P-component precursor", "refseq_ac": [ { "id": "NP_058866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058866", "type": "external" } ], "gene_names_uniprotkb": "Apcs; Ptx2; Sap", "gene_names_refseq": "Apcs; Sap", "protein_names_uniprotkb": "Serum amyloid P-component; SAP", "protein_names_refseq": "serum amyloid P-component precursor; serum amyloid P-component", "tax_id": 10116, "disease": "amyloidosis (Disease Ontology:DOID:9120)", "pathway": " (rno:29339)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14519527;2400402", "class_list": "", "function": "Serum Amyloid P-Component plays an important role in the pathomechanism of neurodegenerative diseases, including Alzheimer's disease by inducing neuronal apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63539", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0001849 complement component C1q complex binding;GO:0046790 virion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045087 innate immune response;GO:0006953 acute-phase response;GO:0048525 negative regulation of viral process;GO:0045656 negative regulation of monocyte differentiation;GO:1903019 negative regulation of glycoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P23680-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11685-1", "uniprot_id": [ { "id": "PSPC_RAT", "url": "https://www.uniprot.org/uniprot/P11685", "type": "external" } ], "mass": 21043.0, "length": 194, "protein_name": "Surfactant protein C", "gene_name": "Sftpc", "organism": "Rat", "refseq_name": "surfactant protein C", "refseq_ac": [ { "id": "NP_059038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059038", "type": "external" } ], "gene_names_uniprotkb": "Sftpc; Sftp2", "gene_names_refseq": "SP-C; Sftpc", "protein_names_uniprotkb": "Surfactant protein C; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL(Val); SP-C", "protein_names_refseq": "Surfactant, pulmonary-associated protein C; pulmonary surfactant-associated protein C; pulmonary surfactant-associated proteolipid SPL(Val); surfactant associated protein C; surfactant protein C", "tax_id": 10116, "disease": "desquamative interstitial pneumonia (Disease Ontology:DOID:0050158); lacrimoauriculodentodigital syndrome 1 (Disease Ontology:DOID:0050331); developmental and epileptic encephalopathy 47 (Disease Ontology:DOID:0080425); lacrimoauriculodentodigital syndrome 3 (Disease Ontology:DOID:0081372); aplasia of lacrimal and salivary glands (Disease Ontology:DOID:0111549); intestinal atresia (Disease Ontology:DOID:10486); hypospadias (Disease Ontology:DOID:10892); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:50683); (R-RNO-5683826)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "2706272;27155084;30341519", "class_list": "", "function": "Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SP-C is present on the surface of exocytosed surfactant particles. Antibodies against SP-C stabilize the released particles when contacting the air-liquid interface, precluding their transformation and the formation of surface films. SP-C acts as an essential, preformed molecular key in the initial stages of surfactant unpacking and surface film formation., [RefSeq, PubMed]; The expression of SP-B and SP-C in GDM group was significantly reduced as compared with control group (P<0.05)...It was concluded that gestational diabetes mellitus can cause fetal lung development and maturation disorders, and FOXA2 in fetal lung tissue decreases while nitrocellulose FOXA2 increases, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52MA6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0097208 alveolar lamellar body;GO:0005771 multivesicular body", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0007585 respiratory gaseous exchange by respiratory system;GO:0051384 response to glucocorticoid;GO:0032526 response to retinoic acid;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P11685-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70580-1", "uniprot_id": [ { "id": "PGRC1_RAT", "url": "https://www.uniprot.org/uniprot/P70580", "type": "external" } ], "mass": 21598.0, "length": 195, "protein_name": "Membrane-associated progesterone receptor component 1", "gene_name": "Pgrmc1", "organism": "Rat", "refseq_name": "membrane-associated progesterone receptor component 1", "refseq_ac": [ { "id": "NP_068534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068534", "type": "external" } ], "gene_names_uniprotkb": "Pgrmc1; 25dx; Lewi; Pgrmc", "gene_names_refseq": "25-Dx; 25Dx; MPR; Pgrmc1; VEMA", "protein_names_uniprotkb": "Membrane-associated progesterone receptor component 1; 25-DX; Acidic 25 kDa protein; VEMA; Ventral midline antigen; mPR", "protein_names_refseq": "acidic 25 kDa protein; membrane-associated progesterone receptor component 1; membrane-bound progesterone receptor; ventral midline antigen", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:291948); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10656251;16641100;22673903;29393594;34645803;34970218;9006096", "class_list": "", "function": "Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (By similarity). May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity (PubMed:9006096). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (By similarity)., [UniProtKB, PubMed, UniProtKB]; PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70606;Q549C4", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005496 steroid binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:1905809 negative regulation of synapse organization;GO:0007613 memory;GO:0008306 associative learning;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70580-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34207-1", "uniprot_id": [ { "id": "PR3D4_RAT", "url": "https://www.uniprot.org/uniprot/P34207", "type": "external" } ], "mass": 25844.0, "length": 223, "protein_name": "Prolactin-3D4", "gene_name": "Prl3d4", "organism": "Rat", "refseq_name": "prolactin-3D4 precursor", "refseq_ac": [ { "id": "NP_150236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_150236", "type": "external" } ], "gene_names_uniprotkb": "Prl3d4; Csh1v", "gene_names_refseq": "Csh1l1; Csh1v; Pl-Iv; Prl3d4", "protein_names_uniprotkb": "Prolactin-3D4; Chorionic somatomammotropin hormone 1 variant; PL-IV; Placental lactogen I variant", "protein_names_refseq": "Chorionic somatomammotropin hormone 1 variant; Placental lactogen-1; chorionic somatomammotropin hormone 1-like 1; placental lactogen I; placental lactogen-1; prolactin-3D4 precursor; prolactin-3D4", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); impulse control disorder (Disease Ontology:DOID:10937); depressive disorder (Disease Ontology:DOID:1596); severe acute respiratory syndrome (Disease Ontology:DOID:2945); carotid artery disease (Disease Ontology:DOID:3407); prolactinoma (Disease Ontology:DOID:5394); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:24282)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1988439;20832857", "class_list": "", "function": "Data indicate that demethylation in PL-Iv upstream region is induced at early stage of placental development; once 5'-flanking region of PL-Iv gene has been demethylated, this status continues throughout gestation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4QRA7", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P34207-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02781-1", "uniprot_id": [ { "id": "PSC2_RAT", "url": "https://www.uniprot.org/uniprot/P02781", "type": "external" } ], "mass": 12828.0, "length": 112, "protein_name": "Prostatic steroid-binding protein C2", "gene_name": "Psbpc2; Scgb1d4", "organism": "Rat", "refseq_name": "prostatic steroid-binding protein C2 precursor", "refseq_ac": [ { "id": "NP_997476", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997476", "type": "external" } ], "gene_names_uniprotkb": "Psbpc2; Scgb1d4; Psbpc2", "gene_names_refseq": "Psbp2; Psbpc2; Scgb1d4", "protein_names_uniprotkb": "Prostatic steroid-binding protein C2; Prostatein peptide C2", "protein_names_refseq": "prostate steriod-binding protein 2; prostatein peptide C2; prostatic steroid-binding protein C2 precursor; prostatic steroid-binding protein C2", "tax_id": 10116, "disease": "", "pathway": " (rno:293731)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2881277;6343081;6896362", "class_list": "", "function": "Part of prostatein which is the major secretory glycoprotein of ventral prostate gland., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005496 steroid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P02781-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07861-1", "uniprot_id": [ { "id": "NEP_RAT", "url": "https://www.uniprot.org/uniprot/P07861", "type": "external" } ], "mass": 85795.0, "length": 750, "protein_name": "Neprilysin", "gene_name": "Mme", "organism": "Rat", "refseq_name": "neprilysin", "refseq_ac": [ { "id": "NP_036740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036740", "type": "external" } ], "gene_names_uniprotkb": "Mme", "gene_names_refseq": "CD10; Mme; Nep; SFE", "protein_names_uniprotkb": "Neprilysin; 3.4.24.11; Atriopeptidase; Enkephalinase; NEP; Neutral endopeptidase 24.11; Neutral endopeptidase; SFE; Skin fibroblast elastase", "protein_names_refseq": "atriopeptidase; membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase); neprilysin; neutral endopeptidase 24.11; skin fibroblast elastase", "tax_id": 10116, "disease": "focal dystonia (Disease Ontology:DOID:0050836); torsion dystonia 1 (Disease Ontology:DOID:0060730); arthrogryposis multiplex congenita-5 (Disease Ontology:DOID:0080981); Charcot-Marie-Tooth disease axonal type 2T (Disease Ontology:DOID:0110160); cerebellar ataxia type 43 (Disease Ontology:DOID:0111745); heart conduction disease (Disease Ontology:DOID:10273); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); diarrhea (Disease Ontology:DOID:13250); Parkinson's disease (Disease Ontology:DOID:14330); dystonia (Disease Ontology:DOID:543); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)", "pathway": " (rno:24590); (R-RNO-2022377); (R-RNO-5578768); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "12835417;15240697;22673903;2703483;2966343;29702204;30531704;33433852;35344141;3555489", "class_list": "", "function": "Caspase Inhibition Restores NEP Expression and Rescues Olfactory Deficit in Rats Caused by Prenatal Hypoxia., [RefSeq, PubMed]; Developmental Profile of Brain Neprilysin Expression Correlates with Olfactory Behaviour of Rats., [RefSeq, PubMed]; In standard light/dark conditions, the results demonstrated an opposite daily rhythm in hypothalamus and pituitary. While the highest levels of AlaAP or enkephalinase activities were measured in hypothalamus during the dark period, they were the highest in the pituitary during the light one., [RefSeq, PubMed]; Study shows that chronic intermittent hypoxia (CIH) induces changes on the expression and activity of neprilysin (NEP) in the brain of rats. Data show that CIH protocol increases the expression and activity of NEP selectively in the temporal cortex., [RefSeq, PubMed]; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:2966343). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:2966343). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (By similarity). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:2966343). Involved in the degradation of the atrial natriuretic factor (ANF) (PubMed:2966343). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "3.4.15.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.15.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0006508 proteolysis;GO:0007611 learning or memory;GO:0007613 memory;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P07861-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49187-1", "uniprot_id": [ { "id": "MK10_RAT", "url": "https://www.uniprot.org/uniprot/P49187", "type": "external" } ], "mass": 52532.0, "length": 464, "protein_name": "Mitogen-activated protein kinase 10", "gene_name": "Mapk10", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase 10 isoform 2", "refseq_ac": [ { "id": "NP_036938", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036938", "type": "external" } ], "gene_names_uniprotkb": "Mapk10; Jnk3; Prkm10", "gene_names_refseq": "Jnk3; Mapk10; SAPKC; SAPb; Serk2", "protein_names_uniprotkb": "Mitogen-activated protein kinase 10; 2.7.11.24; MAP kinase 10; MAPK 10; SAPK-beta; Stress-activated protein kinase JNK3; c-Jun N-terminal kinase 3; p54-beta", "protein_names_refseq": "MAP kinase 10; MAPK 10; SAPK-beta; Stress activated protein kinase beta; c-Jun N-terminal kinase 3; mitogen-activated protein kinase 10 isoform 2; p54-beta; stress-activated protein kinase JNK3", "tax_id": 10116, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); Charcot-Marie-Tooth disease type 4H (Disease Ontology:DOID:0110192); prostate cancer (Disease Ontology:DOID:10283); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); invasive ductal carcinoma (Disease Ontology:DOID:3008); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); X-linked Aarskog syndrome (Disease Ontology:DOID:6683)", "pathway": " (rno:25272); (R-RNO-2559580); (R-RNO-2871796); (R-RNO-450321); (R-RNO-450341)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "11090355;12424734;15944381;18408005;21076496;21468718;29510185;32189007;33307368;8177321", "class_list": "", "function": "Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3., [RefSeq, PubMed]; Data suggest that JNK isoforms are involved in differential regulation of neuronal death and regeneration, and that JNK3 appears to be required for regeneration and survival in the case of an environment permissive for regeneration., [RefSeq, PubMed]; Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicate that Wnt5a-mediated JNK3 activation participates in Ischemia/Reperfusion brain injury by targeting the Dvl-1-beta-arrestin2/JNK3 interaction, [RefSeq, PubMed]; Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Also participates in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (By similarity). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development., [RefSeq, PubMed]; The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0VXR6;D3ZQ33", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004705 JUN kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0007258 JUN phosphorylation;GO:0098969 neurotransmitter receptor transport to postsynaptic membrane;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006468 protein phosphorylation;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P49187-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0HA29-1", "uniprot_id": [ { "id": "NMNA2_RAT", "url": "https://www.uniprot.org/uniprot/Q0HA29", "type": "external" } ], "mass": 34445.0, "length": 307, "protein_name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "gene_name": "Nmnat2", "organism": "Rat", "refseq_name": "nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2", "refseq_ac": [ { "id": "NP_001041507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041507", "type": "external" } ], "gene_names_uniprotkb": "Nmnat2", "gene_names_refseq": "Nmnat2", "protein_names_uniprotkb": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; 2.7.7.18; 2.7.7.1; NMN adenylyltransferase 2; NMN/NaMN adenylyltransferase 2; NaMN adenylyltransferase 2; Nicotinamide mononucleotide adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2", "protein_names_refseq": "NMN adenylyltransferase 2; NMN/NaMN adenylyltransferase 2; naMN adenylyltransferase 1; naMN adenylyltransferase 2; nicotinamide mononucleotide adenylyltransferase 2; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 2", "tax_id": 10116, "disease": "hypertrophic cardiomyopathy (Disease Ontology:DOID:11984)", "pathway": " (rno:289095); (R-RNO-196807)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22449973;37208728", "class_list": "", "function": "Data show that overexpression of Nmnat2 but not its catalytically inactive mutant blocked angiotensin II (Ang II)-induced cardiac hypertrophy, which was dependent on activation of SIRT6 through maintaining the intracellular NAD level., [RefSeq, PubMed]; Dysbiosis of gut microbiota inhibits NMNAT2 to promote neurobehavioral deficits and oxidative stress response in the 6-OHDA-lesioned rat model of Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Also acts as an activator of ADP-ribosylation by supporting the catalytic activity of PARP16 and promoting mono-ADP-ribosylation of ribosomes by PARP16 (By similarity). May be involved in the maintenance of axonal integrity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.1", "type": "external" }, { "id": "2.7.7.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity;GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030424 axon;GO:0045202 synapse", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:0006741 NADP+ biosynthetic process;GO:0009435 NAD+ biosynthetic process;GO:2000766 negative regulation of cytoplasmic translation;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0HA29-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZZ1-1", "uniprot_id": [ { "id": "PXK_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZZ1", "type": "external" } ], "mass": 65098.0, "length": 580, "protein_name": "PX domain-containing protein kinase-like protein", "gene_name": "Pxk", "organism": "Rat", "refseq_name": "PX domain-containing protein kinase-like protein isoform 1", "refseq_ac": [ { "id": "NP_877973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_877973", "type": "external" } ], "gene_names_uniprotkb": "Pxk", "gene_names_refseq": "Pxk", "protein_names_uniprotkb": "PX domain-containing protein kinase-like protein; MONaKA; Modulator of Na,K-ATPase", "protein_names_refseq": "MONaKA; PX domain-containing protein kinase-like protein isoform 1; PX domain-containing protein kinase-like protein; PX serine/threonine kinase; modulator of Na,K-ATPase", "tax_id": 10116, "disease": "polycythemia due to hypoxia (Disease Ontology:DOID:2835)", "pathway": " (rno:306203)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNZ7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006954 inflammatory response;GO:0050804 modulation of chemical synaptic transmission;GO:0032780 negative regulation of ATP-dependent activity;GO:0043271 negative regulation of monoatomic ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4FZZ1-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09320-1", "uniprot_id": [ { "id": "PR4A1_RAT", "url": "https://www.uniprot.org/uniprot/P09320", "type": "external" } ], "mass": 26388.0, "length": 227, "protein_name": "Prolactin-4A1", "gene_name": "Prl4a1", "organism": "Rat", "refseq_name": "prolactin-4A1 precursor", "refseq_ac": [ { "id": "NP_058732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058732", "type": "external" } ], "gene_names_uniprotkb": "Prl4a1; Prlpa", "gene_names_refseq": "Ghd3; Plpa; Prl4a1; Prlpa", "protein_names_uniprotkb": "Prolactin-4A1; PLP-A; PRL-like protein A; Placental prolactin-like protein A", "protein_names_refseq": "PLP-A; PRL-like protein A; growth hormone d3; placental prolactin-like protein A; prolactin-4A1 precursor; prolactin-4A1; prolactin-like protein A", "tax_id": 10116, "disease": "", "pathway": " (rno:24656)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12850282;12885563;3755436", "class_list": "", "function": "Both interstitial and endovascular rat trophoblast cells synthesize plpa., [RefSeq, PubMed]; PLP-A interactions with NK cells are not mediated by receptors of known modulators of NK cell function. PLP-A causes intracellular calcium mobilization to increase and suppresses production of IFNgamma in uterine NK cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4QR95", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P09320-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9D0-1", "uniprot_id": [ { "id": "PGLT1_RAT", "url": "https://www.uniprot.org/uniprot/G3V9D0", "type": "external" } ], "mass": 46510.0, "length": 392, "protein_name": "Protein O-glucosyltransferase 1", "gene_name": "Poglut1", "organism": "Rat", "refseq_name": "protein O-glucosyltransferase 1 precursor", "refseq_ac": [ { "id": "NP_001094122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094122", "type": "external" } ], "gene_names_uniprotkb": "Poglut1", "gene_names_refseq": "Ktelc1; Poglut1; RGD1306248", "protein_names_uniprotkb": "Protein O-glucosyltransferase 1; 2.4.1.376; 2.4.2.63; O-glucosyltransferase Rumi homolog; Protein O-xylosyltransferase", "protein_names_refseq": "KTEL (Lys-Tyr-Glu-Leu) containing 1; O-glucosyltransferase Rumi homolog; protein O-glucosyltransferase 1 precursor; protein O-xylosyltransferase", "tax_id": 10116, "disease": "Dowling-Degos disease (Disease Ontology:DOID:0060256); autosomal recessive limb-girdle muscular dystrophy type 2Z (Disease Ontology:DOID:0080762); autosomal recessive limb-girdle muscular dystrophy (Disease Ontology:DOID:0110274)", "pathway": " (rno:288091)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21949356;29393594;38843836", "class_list": "glycogene;glycosyltransferase", "function": "Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (By similarity). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (By similarity). Notch glucosylation does not affect Notch ligand binding (By similarity). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.376", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.376", "type": "external" }, { "id": "2.4.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.63", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0046527 glucosyltransferase activity;GO:0035252 UDP-xylosyltransferase activity;GO:0035251 UDP-glucosyltransferase activity;GO:0140561 EGF-domain serine glucosyltransferase activity;GO:0140562 EGF-domain serine xylosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0012505 endomembrane system", "go_biological_process": "GO:0010470 regulation of gastrulation;GO:0072359 circulatory system development;GO:0006493 protein O-linked glycosylation;GO:0045747 positive regulation of Notch signaling pathway;GO:0001756 somitogenesis", "synthesized_glycan_count": 6710, "hit_score": 0.6, "record_id": "G3V9D0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQV1-1", "uniprot_id": [ { "id": "TX1B3_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQV1", "type": "external" } ], "mass": 11050.0, "length": 98, "protein_name": "Tax1-binding protein 3", "gene_name": "Tax1bp3", "organism": "Rat", "refseq_name": "tax1-binding protein 3 isoform 2", "refseq_ac": [ { "id": "NP_001020590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020590", "type": "external" } ], "gene_names_uniprotkb": "Tax1bp3", "gene_names_refseq": "Tax1bp3", "protein_names_uniprotkb": "Tax1-binding protein 3", "protein_names_refseq": "Tax1 (human T-cell leukemia virus type I) binding protein 3; tax1-binding protein 3 isoform 2; tax1-binding protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:360564)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16855024", "class_list": "", "function": "May regulate a number of protein-protein interactions by competing for PDZ domain binding sites., [UniProtKB, UniProtKB]; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0001650 fibrillar center", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0007266 Rho protein signal transduction;GO:0032489 regulation of Cdc42 protein signal transduction;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4QQV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24800-1", "uniprot_id": [ { "id": "PR6A1_RAT", "url": "https://www.uniprot.org/uniprot/P24800", "type": "external" } ], "mass": 27148.0, "length": 234, "protein_name": "Prolactin-6A1", "gene_name": "Prl6a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prl6a1; Prlpb", "gene_names_refseq": "", "protein_names_uniprotkb": "Prolactin-6A1; PLP-B; PRL-like protein B; Placental prolactin-like protein B", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:24657)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3185566", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q63439", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P24800-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86411-1", "uniprot_id": [ { "id": "RGPA2_RAT", "url": "https://www.uniprot.org/uniprot/P86411", "type": "external" } ], "mass": 210333.0, "length": 1872, "protein_name": "Ral GTPase-activating protein subunit alpha-2", "gene_name": "Ralgapa2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ralgapa2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ral GTPase-activating protein subunit alpha-2; 250 kDa substrate of Akt; AS250; p220", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:296211)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19520869;22673903", "class_list": "", "function": "Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0032880 regulation of protein localization;GO:0090630 activation of GTPase activity;GO:0060178 regulation of exocyst localization;GO:0032484 Ral protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P86411-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08542-1", "uniprot_id": [ { "id": "UDB17_RAT", "url": "https://www.uniprot.org/uniprot/P08542", "type": "external" } ], "mass": 60525.0, "length": 530, "protein_name": "UDP-glucuronosyltransferase 2B17", "gene_name": "Ugt2b15; Ugt2b17; Ugt2b37", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ugt2b15; Ugt2b17; Ugt2b37; LOC102550717; Ugt2b15; Ugt2b3; Ugt2b5", "gene_names_refseq": "", "protein_names_uniprotkb": "UDP-glucuronosyltransferase 2B17; 17-beta-hydroxysteroid-specific UDPGT; 2.4.1.17; RLUG38; Testosterone, dihydrotestosterone, and beta-estradiol-specific UDPGT; UDP-glucuronosyltransferase 2B5; UDPGT 2B17; UDPGT 2B5; UDPGTr-3; UGT2B17", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:266685); (rno:29623); (R-RNO-156588); (R-RNO-9749641); (R-RNO-9757110)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "1692835;18719240;3108864;3110162", "class_list": "glycogene;glycosyltransferase", "function": "UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol) (By similarity) (PubMed:18719240)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P16915", "ec_number_list": [ { "id": "2.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0071378 cellular response to growth hormone stimulus;GO:0032496 response to lipopolysaccharide;GO:0071394 cellular response to testosterone stimulus;GO:0071361 cellular response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P08542-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07897-1", "uniprot_id": [ { "id": "PGCA_RAT", "url": "https://www.uniprot.org/uniprot/P07897", "type": "external" } ], "mass": 221118.0, "length": 2124, "protein_name": "Aggrecan core protein", "gene_name": "Acan", "organism": "Rat", "refseq_name": "aggrecan core protein precursor", "refseq_ac": [ { "id": "NP_071526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071526", "type": "external" } ], "gene_names_uniprotkb": "Acan; Agc1; Agc", "gene_names_refseq": "Acan; Agc1; Agc", "protein_names_uniprotkb": "Aggrecan core protein; CSPCP; Cartilage-specific proteoglycan core protein", "protein_names_refseq": "CSPCP; aggrecan 1; aggrecan core protein precursor; aggrecan core protein; aggrecan, structural proteoglycan of cartilage; cartilage-specific proteoglycan core protein", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); spondyloepiphyseal dysplasia Kimberley type (Disease Ontology:DOID:0112282); status epilepticus (Disease Ontology:DOID:1824); multiple sclerosis (Disease Ontology:DOID:2377); achondroplasia (Disease Ontology:DOID:4480); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (rno:58968); (R-RNO-1474228); (R-RNO-2022854); (R-RNO-2022857); (R-RNO-3000178)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "15296743;2424893;26165845;30981839;3693370;3693371;37227215", "class_list": "", "function": "Brachyury positively regulates extracellular matrix synthesis via directly promoting aggrecan transcription in nucleus pulposus., [RefSeq, PubMed]; E1 and E2 enhancer activities in type II collagen and aggrecan are regulated through distinct epigenetic modifications by histone deacetylase 10 and sirtuin 6., [RefSeq, PubMed]; The ERK1/2 and Smad2/3 signaling pathways regulate type II collagen and aggrecan expression in rat chondrocytes., [RefSeq, PubMed]; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 15, "predicted_n_glycosites": 6, "predicted_o_glycosites": 9, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005201 extracellular matrix structural constituent;GO:0005540 hyaluronic acid binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007155 cell adhesion;GO:0007507 heart development;GO:0021510 spinal cord development;GO:0030336 negative regulation of cell migration;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07897-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2ABP3-1", "uniprot_id": [ { "id": "PGAP2_RAT", "url": "https://www.uniprot.org/uniprot/Q2ABP3", "type": "external" } ], "mass": 29491.0, "length": 254, "protein_name": "Acyltransferase PGAP2", "gene_name": "Pgap2", "organism": "Rat", "refseq_name": "acyltransferase PGAP2", "refseq_ac": [ { "id": "NP_446347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446347", "type": "external" } ], "gene_names_uniprotkb": "Pgap2; Frag1", "gene_names_refseq": "Frag1; Pgap2", "protein_names_uniprotkb": "Acyltransferase PGAP2; 2.3.-.-; FGF receptor-activating protein 1; Post-GPI attachment to proteins factor 2", "protein_names_refseq": "FGF receptor-activating protein 1; acyltransferase PGAP2; post-GPI attachment to proteins factor 2", "tax_id": 10116, "disease": "hyperphosphatasia with impaired intellectual development syndrome 3 (Disease Ontology:DOID:0070435)", "pathway": " (rno:116675)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16407401;8799135", "class_list": "", "function": "Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the second step of the fatty acid remodeling, by reacylating a lyso-GPI intermediate at sn-2 of inositol phosphate by a saturated chain. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results demonstrate that PGAP2 is involved in the processing of GPI-APs required for their stable expression at the cell surface, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70561", "ec_number_list": [ { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" } ], "go_molecular_function": "GO:0016740 transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2ABP3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58751-1", "uniprot_id": [ { "id": "RELN_RAT", "url": "https://www.uniprot.org/uniprot/P58751", "type": "external" } ], "mass": 387531.0, "length": 3462, "protein_name": "Reelin", "gene_name": "Reln", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Reln", "gene_names_refseq": "", "protein_names_uniprotkb": "Reelin; 3.4.21.-", "protein_names_refseq": "", "tax_id": 10116, "disease": "Parkinson's disease 1 (Disease Ontology:DOID:0060367); familial temporal lobe epilepsy 7 (Disease Ontology:DOID:0060751); Norman-Roberts syndrome (Disease Ontology:DOID:0060902); Alzheimer's disease (Disease Ontology:DOID:10652); autistic disorder (Disease Ontology:DOID:12849); Down syndrome (Disease Ontology:DOID:14250); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); substance-related disorder (Disease Ontology:DOID:303); bipolar disorder (Disease Ontology:DOID:3312); temporal lobe epilepsy (Disease Ontology:DOID:3328); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (rno:24718); (R-RNO-8866376)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10328932;12670697", "class_list": "", "function": "Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 20, "predicted_n_glycosites": 20, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "Q80T65", "ec_number_list": [ { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0070325 lipoprotein particle receptor binding;GO:0048018 receptor ligand activity;GO:0070326 very-low-density lipoprotein particle receptor binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0001934 positive regulation of protein phosphorylation;GO:0006508 proteolysis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58751-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50170-1", "uniprot_id": [ { "id": "RDH16_RAT", "url": "https://www.uniprot.org/uniprot/P50170", "type": "external" } ], "mass": 35597.0, "length": 317, "protein_name": "Retinol dehydrogenase 16", "gene_name": "LOC120093075; Rdh16", "organism": "Rat", "refseq_name": "retinol dehydrogenase 16", "refseq_ac": [ { "id": "NP_954678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954678", "type": "external" } ], "gene_names_uniprotkb": "LOC120093075; Rdh16; Rdh16; Rdh2; Rodh1; Rodhii", "gene_names_refseq": "Rdh16; Rdh2; RoDHII", "protein_names_uniprotkb": "Retinol dehydrogenase 16; 1.1.1.105; 1.1.1.209; 1.1.1.315; 1.1.1.53; 29 kDa protein; RODH II; Retinol dehydrogenase 2; Retinol dehydrogenase type 1; Retinol dehydrogenase type II", "protein_names_refseq": "29 kDa protein; retinol dehydrogenase 16 (all-trans); retinol dehydrogenase 16; retinol dehydrogenase 2-like; retinol dehydrogenase 2; retinol dehydrogenase type 1; retinol dehydrogenase type 2; retinol dehydrogenase type II (RODH II)", "tax_id": 10116, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419)", "pathway": " (rno:299511)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11601977;7499345;8251521", "class_list": "", "function": "Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:7499345). Has higher activity towards CRBP-bound retinol than with free retinol (By similarity). Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.1", "type": "external" }, { "id": "1.1.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.66", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0047044 androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity;GO:0106429 11-cis-retinol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0042573 retinoic acid metabolic process;GO:0006702 androgen biosynthetic process;GO:0008202 steroid metabolic process;GO:1900054 positive regulation of retinoic acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50170-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04474-1", "uniprot_id": [ { "id": "PRP3_RAT", "url": "https://www.uniprot.org/uniprot/P04474", "type": "external" } ], "mass": 21403.0, "length": 206, "protein_name": "Acidic proline-rich protein PRP33", "gene_name": "Prb1; Prpg1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prb1; Prpg1; Prpg1", "gene_names_refseq": "", "protein_names_uniprotkb": "Acidic proline-rich protein PRP33; Proline-rich proteoglycan 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "3840480;6547951", "class_list": "", "function": "May protect teeth by binding to tannins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04474-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51574-1", "uniprot_id": [ { "id": "S15A1_RAT", "url": "https://www.uniprot.org/uniprot/P51574", "type": "external" } ], "mass": 78929.0, "length": 710, "protein_name": "Solute carrier family 15 member 1", "gene_name": "Slc15a1", "organism": "Rat", "refseq_name": "solute carrier family 15 member 1 isoform pgPepT1", "refseq_ac": [ { "id": "NP_001073307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073307", "type": "external" } ], "gene_names_uniprotkb": "Slc15a1; Pept1", "gene_names_refseq": "Pept1; Slc15a1", "protein_names_uniprotkb": "Solute carrier family 15 member 1; Intestinal H(+)/peptide cotransporter; Oligopeptide transporter, small intestine isoform; Peptide transporter 1; Proton-coupled dipeptide cotransporter", "protein_names_refseq": "intestinal H(+)/peptide cotransporter; peptide transporter 1; pineal gland-specific PEPT1; proton-coupled dipeptide cotransporter; solute carrier family 15 (oligopeptide transporter), member 1; solute carrier family 15 member 1 isoform pgPepT1", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:117261); (R-RNO-427975)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15684415;19103603;32341465;35226682;35386060;36567554;8531138;8605246", "class_list": "", "function": "Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation., [RefSeq, PubMed]; Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (By similarity). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule., [RefSeq, PubMed]; Sex-specific and concentration-dependent influence of Cremophor RH 40 on ampicillin absorption via its effect on intestinal membrane transporters in rats. Publication Status: Online-Only, [RefSeq, PubMed]; [Role of cholinergic anti-inflammatory pathway in Ghrelin regulation of peptide transporter 1 expression in small intestinal epithelium of septic rats]., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q5EML1", "ec_number_list": [], "go_molecular_function": "GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity;GO:0015333 peptide:proton symporter activity;GO:0016248 channel inhibitor activity;GO:0042937 tripeptide transmembrane transporter activity;GO:0071916 dipeptide transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0072237 metanephric proximal tubule development;GO:0015031 protein transport;GO:0006857 oligopeptide transport;GO:0140206 dipeptide import across plasma membrane;GO:0051956 negative regulation of amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P51574-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58200-1", "uniprot_id": [ { "id": "VTI1B_RAT", "url": "https://www.uniprot.org/uniprot/P58200", "type": "external" } ], "mass": 26703.0, "length": 232, "protein_name": "Vesicle transport through interaction with t-SNAREs homolog 1B", "gene_name": "Vti1b", "organism": "Rat", "refseq_name": "vesicle transport through interaction with t-SNAREs homolog 1B isoform X1", "refseq_ac": [ { "id": "XP_038967518", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_038967518", "type": "external" } ], "gene_names_uniprotkb": "Vti1b; Vti1l1", "gene_names_refseq": "RGD1560475; Vti1-rp1; Vti1b; Vti1l1", "protein_names_uniprotkb": "Vesicle transport through interaction with t-SNAREs homolog 1B; Vesicle transport v-SNARE protein Vti1-like 1; Vti1-rp1", "protein_names_refseq": "vesicle transport through interaction with t-SNAREs homolog 1B isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:100359512); (R-RNO-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11101518;15133481", "class_list": "", "function": "SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:11101518, PubMed:15133481). On late endosomes, regulates trafficking from late endosomes to the lysosome (PubMed:11101518)., [UniProtKB, PubMed, PubMed]; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019869 chloride channel inhibitor activity;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016236 macroautophagy;GO:0042147 retrograde transport, endosome to Golgi;GO:1903076 regulation of protein localization to plasma membrane;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58200-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2VWP9-1", "uniprot_id": [ { "id": "PRTG_RAT", "url": "https://www.uniprot.org/uniprot/Q2VWP9", "type": "external" } ], "mass": 131080.0, "length": 1193, "protein_name": "Protogenin", "gene_name": "Prtg", "organism": "Rat", "refseq_name": "protogenin precursor", "refseq_ac": [ { "id": "NP_001032740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032740", "type": "external" } ], "gene_names_uniprotkb": "Prtg", "gene_names_refseq": "Prtg; RGD1307157", "protein_names_uniprotkb": "Protogenin; Protein Shen-Dan", "protein_names_refseq": "protein Shen-Dan; protogenin A; protogenin homolog (Gallus gallus); protogenin precursor; shen-dan", "tax_id": 10116, "disease": "", "pathway": " (rno:315806)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in anteroposterior axis elongation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0050768 negative regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2VWP9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97525-1", "uniprot_id": [ { "id": "TNR8_RAT", "url": "https://www.uniprot.org/uniprot/P97525", "type": "external" } ], "mass": 52613.0, "length": 492, "protein_name": "Tumor necrosis factor receptor superfamily member 8", "gene_name": "Tnfrsf8", "organism": "Rat", "refseq_name": "tumor necrosis factor receptor superfamily member 8 precursor", "refseq_ac": [ { "id": "NP_062008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062008", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf8; Cd30", "gene_names_refseq": "Cd30; Tnfrsf8", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Lymphocyte activation antigen CD30", "protein_names_refseq": "CD30L receptor; Tumor necrosis factor superfamily member 8; lymphocyte activation antigen CD30; tumor necrosis factor receptor superfamily member 8 precursor; tumor necrosis factor receptor superfamily, member 8; tumor necrosis factor superfamily, member CD30", "tax_id": 10116, "disease": "", "pathway": " (rno:25069); (R-RNO-5669034)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8982082", "class_list": "", "function": "Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts (By similarity). Regulates gene expression through activation of NF-kappa-B (PubMed:8982082)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2K7Z6", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032759 positive regulation of TRAIL production;GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0032760 positive regulation of tumor necrosis factor production;GO:0071260 cellular response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P97525-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49793-1", "uniprot_id": [ { "id": "NUP98_RAT", "url": "https://www.uniprot.org/uniprot/P49793", "type": "external" } ], "mass": 197283.0, "length": 1816, "protein_name": "Nuclear pore complex protein Nup98-Nup96", "gene_name": "Nup98", "organism": "Rat", "refseq_name": "nuclear pore complex protein Nup98-Nup96 proprotein", "refseq_ac": [ { "id": "NP_112336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112336", "type": "external" } ], "gene_names_uniprotkb": "Nup98", "gene_names_refseq": "Nup98", "protein_names_uniprotkb": "Nuclear pore complex protein Nup98-Nup96; 3.4.21.-; 96 kDa nucleoporin; 98 kDa nucleoporin; Nucleoporin Nup96; Nucleoporin Nup98; Nup96; Nup98", "protein_names_refseq": "98 kDa nucleoporin; nuclear pore complex protein Nup98-Nup96 proprotein; nuclear pore complex protein Nup98-Nup96; nuclear pore complex protein Nup98; nucleoporin 98kDa; nucleoporin Nup98", "tax_id": 10116, "disease": "T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:81738); (R-RNO-141430); (R-RNO-141444); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9615933); (R-RNO-9648025)", "pathway_count": 26, "publication_count": 5, "publication_id_list": "10087256;11839768;22673903;29393594;7736573", "class_list": "", "function": "Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC., [UniProtKB, UniProtKB]; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZMW4", "ec_number_list": [ { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042277 peptide binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006508 proteolysis;GO:0051292 nuclear pore complex assembly;GO:0051028 mRNA transport;GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P49793-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C6B8-1", "uniprot_id": [ { "id": "SVEP1_RAT", "url": "https://www.uniprot.org/uniprot/P0C6B8", "type": "external" } ], "mass": 387355.0, "length": 3564, "protein_name": "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1", "gene_name": "Svep1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Svep1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "17139625", "class_list": "", "function": "Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription (By similarity). Required for embryonic lymphatic vascular development, via mediating the correct formation of the first lymphovenous contact site and tight association of the lymphatic endothelium with the venous endothelium (By similarity). Represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells, via its interaction with integrins, thereby inhibiting vasocontraction (By similarity). Promotes platelet activation, via its interaction with PEAR1 and subsequent activation of AKT/mTOR signaling (By similarity). Plays a role in epidermal development and keratinocyte differentiation, independent of cell-cell adhesion (By similarity). May play a role in initial cell attachment of stromal osteogenic cells (By similarity). May promote myoblast cell adhesion when in the presence of integrin ITGA9:ITGB1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 2, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0098640 integrin binding involved in cell-matrix adhesion", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0036303 lymph vessel morphogenesis;GO:0031099 regeneration;GO:0008544 epidermis development;GO:0045906 negative regulation of vasoconstriction;GO:0048014 Tie signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C6B8-1", "record_type": "protein", "filter_code": "0000000.0000100.001000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36407-1", "uniprot_id": [ { "id": "TRI23_RAT", "url": "https://www.uniprot.org/uniprot/P36407", "type": "external" } ], "mass": 63892.0, "length": 573, "protein_name": "E3 ubiquitin-protein ligase TRIM23", "gene_name": "Trim23", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM23", "refseq_ac": [ { "id": "NP_001094107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094107", "type": "external" } ], "gene_names_uniprotkb": "Trim23; Ard-1; Ard1; Arfd1", "gene_names_refseq": "Ard1; Arfd1; Trim23", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM23; 2.3.2.27; ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING-type E3 ubiquitin transferase TRIM23; Tripartite motif-containing protein 23", "protein_names_refseq": "ADP-ribosylation factor domain protein 1, 64kD; ADP-ribosylation factor domain-containing protein 1; E3 ubiquitin-protein ligase TRIM23; GTP-binding protein ARD-1; RING-type E3 ubiquitin transferase TRIM23; nucleotide binding protein; tripartite motif protein 23; tripartite motif-containing protein 23", "tax_id": 10116, "disease": "", "pathway": " (rno:81002)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "31621984;37495427;8473324", "class_list": "", "function": "Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Epidermal growth factor receptor-extracellular-regulated kinase blockade upregulates TRIM32 signaling cascade and promotes neurogenesis after spinal cord injury., [RefSeq, PubMed]; Integrated analysis and validation of TRIM23/p53 signaling pathway in hepatic stellate cells ferroptosis and liver fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3ZT39", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0010508 positive regulation of autophagy;GO:0016567 protein ubiquitination;GO:0016192 vesicle-mediated transport;GO:0031401 positive regulation of protein modification process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P36407-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10631-1", "uniprot_id": [ { "id": "PYY_RAT", "url": "https://www.uniprot.org/uniprot/P10631", "type": "external" } ], "mass": 11121.0, "length": 98, "protein_name": "Peptide YY", "gene_name": "Pyy", "organism": "Rat", "refseq_name": "peptide YY precursor", "refseq_ac": [ { "id": "NP_001029252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029252", "type": "external" } ], "gene_names_uniprotkb": "Pyy", "gene_names_refseq": "GHYY; Pyy; RATGHYY; Yy; peptide-YY", "protein_names_uniprotkb": "Peptide YY; PYY-II; PYY; Peptide tyrosine tyrosine", "protein_names_refseq": "peptide YY precursor; peptide tyrosine tyrosine; peptide tyrosine-tyrosine (YY)", "tax_id": 10116, "disease": "", "pathway": " (rno:287730); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12167864;1890992;27117413;28237410;29042449;30222528;3413293;3654598;37228045", "class_list": "", "function": "Additional analysis of the findings demonstrated significant interactions of ovarian cycle stage and fed/fasted status with age on GLP-1, but not PYY plasma concentrations, [RefSeq, PubMed]; Is a NPY2R agonist involved in the down-regulation of appetite and food intake, probably acting on receptors located on proopiomelanocortin(POMC)-releasing and neuropeptide Y(NPY)-releasing neurons in the arcuate nucleus of hypothalamus (PubMed:12167864). In NPY-releasing neurons, NPY2R activation by PYY(3-36) leads to membrane hyperpolarization and reduced release of the orexigenic neuropeptide NPY (By similarity)., [UniProtKB, PubMed, UniProtKB]; Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Also binds NPY5R. Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by PYY also leads to an increase of intracellular Ca(2+) levels (By similarity). This gut peptide inhibits exocrine pancreatic secretion (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Peptide YY mediates the satiety effects of diets enriched with whey protein fractions in male rats, [RefSeq, PubMed]; RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb. Publication Status: Online-Only, [RefSeq, PubMed]; The role of calcium sensing receptors in GLP-1 and PYY secretion after acute intraduodenal administration of L-Tryptophan in rats., [RefSeq, PubMed]; These findings indicate that the mechanism underlying type 2 diabetes remission may be mediated by PYY., [RefSeq, PubMed]; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3C1E8", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0048018 receptor ligand activity;GO:0031841 neuropeptide Y receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0007218 neuropeptide signaling pathway;GO:0042755 eating behavior;GO:0007631 feeding behavior;GO:0032096 negative regulation of response to food", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P10631-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88664-1", "uniprot_id": [ { "id": "TAOK1_RAT", "url": "https://www.uniprot.org/uniprot/O88664", "type": "external" } ], "mass": 115952.0, "length": 1001, "protein_name": "Serine/threonine-protein kinase TAO1", "gene_name": "Taok1", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase TAO1", "refseq_ac": [ { "id": "NP_775449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775449", "type": "external" } ], "gene_names_uniprotkb": "Taok1; Tao1", "gene_names_refseq": "Taok1", "protein_names_uniprotkb": "Serine/threonine-protein kinase TAO1; 2.7.11.1; Thousand and one amino acid protein 1", "protein_names_refseq": "serine/threonine-protein kinase TAO1; thousand and one amino acid protein 1", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cancer (Disease Ontology:DOID:162); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (rno:286993); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "14517247;17047359;18216281;22673903;23472202;31652447;39121041;9786855", "class_list": "", "function": "Inhibition of miR-183 in cochlear organotypic culture leads to upregulation of Taok1. Exposure to noise caused a significant upregulation of Taok1., [RefSeq, PubMed]; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G protein-coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. During fetal development, it plays an essential role in the regulation of neuronal differentiation and migration to the cortical plate (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; TAOK1-mediated regulation of the YAP/TEAD pathway as a potential therapeutic target in heart failure. Publication Status: Online-Only, [RefSeq, PubMed]; Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006281 DNA repair;GO:0006468 protein phosphorylation;GO:0032956 regulation of actin cytoskeleton organization;GO:0046330 positive regulation of JNK cascade;GO:0070050 neuron cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O88664-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31394-1", "uniprot_id": [ { "id": "PROC_RAT", "url": "https://www.uniprot.org/uniprot/P31394", "type": "external" } ], "mass": 51912.0, "length": 461, "protein_name": "Vitamin K-dependent protein C", "gene_name": "Proc", "organism": "Rat", "refseq_name": "vitamin K-dependent protein C precursor", "refseq_ac": [ { "id": "NP_036935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036935", "type": "external" } ], "gene_names_uniprotkb": "Proc", "gene_names_refseq": "Proc", "protein_names_uniprotkb": "Vitamin K-dependent protein C; 3.4.21.69; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV", "protein_names_refseq": "anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; vitamin K-dependent protein C precursor; vitamin K-dependent protein C", "tax_id": 10116, "disease": "thrombosis (Disease Ontology:DOID:0060903); thrombophilia due to activated protein C resistance (Disease Ontology:DOID:0111902); autosomal recessive thrombophilia due to protein C deficiency (Disease Ontology:DOID:0111904); autosomal dominant thrombophilia due to protein C deficiency (Disease Ontology:DOID:0111909); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); thrombotic thrombocytopenic purpura (Disease Ontology:DOID:10772); disseminated intravascular coagulation (Disease Ontology:DOID:11247); toxic shock syndrome (Disease Ontology:DOID:14115); central retinal vein occlusion (Disease Ontology:DOID:2450); thrombophilia (Disease Ontology:DOID:2452); asthma (Disease Ontology:DOID:2841); antiphospholipid syndrome (Disease Ontology:DOID:2988); acute kidney failure (Disease Ontology:DOID:3021); protein C deficiency (Disease Ontology:DOID:3756); myocardial infarction (Disease Ontology:DOID:5844); pulmonary embolism (Disease Ontology:DOID:9477); placental abruption (Disease Ontology:DOID:9667)", "pathway": " (rno:25268); (R-RNO-159740); (R-RNO-159763); (R-RNO-159782); (R-RNO-202733); (R-RNO-381426); (R-RNO-8957275); (R-RNO-9769733); (R-RNO-9769739); (R-RNO-9769743)", "pathway_count": 10, "publication_count": 2, "publication_id_list": "1627650;25813362", "class_list": "", "function": "Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Vascular endothelial damage in Lipopolysaccharide-induced sepsis model is attenuated by activated protein C., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "4.1.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.4.21.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5", "type": "external" }, { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0070012 oligopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:1905370 serine-type endopeptidase complex", "go_biological_process": "GO:0044537 regulation of circulating fibrinogen levels;GO:0001889 liver development;GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P31394-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50279-1", "uniprot_id": [ { "id": "STX2_RAT", "url": "https://www.uniprot.org/uniprot/P50279", "type": "external" } ], "mass": 33359.0, "length": 290, "protein_name": "Syntaxin-2", "gene_name": "Stx2", "organism": "Rat", "refseq_name": "syntaxin-2 isoform 1", "refseq_ac": [ { "id": "NP_036880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036880", "type": "external" } ], "gene_names_uniprotkb": "Stx2; Epim", "gene_names_refseq": "Epim; Stx2", "protein_names_uniprotkb": "Syntaxin-2; Epimorphin", "protein_names_refseq": "epimorphin; syntaxin-2 isoform 1", "tax_id": 10116, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); graft-versus-host disease (Disease Ontology:DOID:0081267); age related macular degeneration 12 (Disease Ontology:DOID:0110024); otitis media (Disease Ontology:DOID:10754); portal hypertension (Disease Ontology:DOID:10762); sciatic neuropathy (Disease Ontology:DOID:11446); retinal vasculitis (Disease Ontology:DOID:11563); uveitis (Disease Ontology:DOID:13141); cystitis (Disease Ontology:DOID:1679); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); atopic dermatitis (Disease Ontology:DOID:3310); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); borna disease (Disease Ontology:DOID:5154); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); prion disease (Disease Ontology:DOID:649); psoriasis (Disease Ontology:DOID:8893); hepatopulmonary syndrome (Disease Ontology:DOID:900); systemic lupus erythematosus (Disease Ontology:DOID:9074); pulmonary embolism (Disease Ontology:DOID:9477); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25130)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "21935930;22673903;24971829;25119302;28560580;7690687;8938452", "class_list": "", "function": "Epimorphin has morphogenetic effects on several epithelial tissues, including those of lung., [RefSeq, PubMed]; Epimorphin regulates bile duct formation of WB-F344 cells through effects on RhoA and C/EBPbeta, implicating a dual aspect of this morphoregulator in bile duct epithelial morphogenesis., [RefSeq, PubMed]; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-124a aggravates lipopolysaccharide-induced cardiac dysfunction and the miR-124a/STX2 pathway might serve as the potential diagnostic and therapeutic targets for septic cardiac dysfunction., [RefSeq, PubMed]; These data provide evidence for EPIM and SOX9 functioning by mutual negative feedback to regulate attributes of the quiescent or activated state of HSCs. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08846;Q08847;Q08848", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0048306 calcium-dependent protein binding;GO:0005198 structural molecule activity;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface", "go_biological_process": "GO:0030033 microvillus assembly;GO:0006886 intracellular protein transport;GO:0030154 cell differentiation;GO:0030855 epithelial cell differentiation;GO:0007340 acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P50279-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53767-1", "uniprot_id": [ { "id": "VGFR1_RAT", "url": "https://www.uniprot.org/uniprot/P53767", "type": "external" } ], "mass": 150250.0, "length": 1336, "protein_name": "Vascular endothelial growth factor receptor 1", "gene_name": "Flt1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Flt1; Flt-1; LOC100911280; Vegfr1", "gene_names_refseq": "", "protein_names_uniprotkb": "Vascular endothelial growth factor receptor 1; 2.7.10.1; FLT-1; Fms-like tyrosine kinase 1; Tyrosine-protein kinase receptor FLT; VEGFR-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); Keshan disease (Disease Ontology:DOID:0050083); ductal carcinoma in situ (Disease Ontology:DOID:0060074); atrial fibrillation (Disease Ontology:DOID:0060224); cerebral cavernous malformation (Disease Ontology:DOID:0060669); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); pre-eclampsia (Disease Ontology:DOID:10591); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sickle cell anemia (Disease Ontology:DOID:10923); corneal neovascularization (Disease Ontology:DOID:11382); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); Kawasaki disease (Disease Ontology:DOID:13378); eosinophilic esophagitis (Disease Ontology:DOID:13922); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); Leydig cell tumor (Disease Ontology:DOID:2696); allergic contact dermatitis (Disease Ontology:DOID:3042); carcinoma (Disease Ontology:DOID:305); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); thyroid gland carcinoma (Disease Ontology:DOID:3963); tuberculosis (Disease Ontology:DOID:399); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); multiple chemical sensitivity (Disease Ontology:DOID:4661); liver cirrhosis (Disease Ontology:DOID:5082); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); hepatocellular carcinoma (Disease Ontology:DOID:684); peptic ulcer disease (Disease Ontology:DOID:750); osteoarthritis (Disease Ontology:DOID:8398); prostate carcinoma in situ (Disease Ontology:DOID:8634); vascular dementia (Disease Ontology:DOID:8725); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (R-RNO-194306); (R-RNO-195399)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8058332", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to the activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC, YES1 and PLCG, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 and PTK2/FAK1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 47, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0042802 identical protein binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005021 vascular endothelial growth factor receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0060252 positive regulation of glial cell proliferation;GO:1990384 hyaloid vascular plexus regression;GO:0001525 angiogenesis;GO:0006468 protein phosphorylation;GO:0006940 regulation of smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P53767-1", "record_type": "protein", "filter_code": "0000000.1000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V686-1", "uniprot_id": [ { "id": "RETNG_RAT", "url": "https://www.uniprot.org/uniprot/G3V686", "type": "external" } ], "mass": 11822.0, "length": 111, "protein_name": "Resistin-like gamma", "gene_name": "Retnlg", "organism": "Rat", "refseq_name": "resistin-like gamma precursor", "refseq_ac": [ { "id": "NP_853656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853656", "type": "external" } ], "gene_names_uniprotkb": "Retnlg", "gene_names_refseq": "Retnlg; retn1g", "protein_names_uniprotkb": "Resistin-like gamma; RELMgamma; Resistin-like molecule gamma", "protein_names_refseq": "RELMgamma; resistin-like beta; resistin-like gamma precursor; resistin-like molecule gamma", "tax_id": 10116, "disease": "", "pathway": " (rno:288135)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12782128;33407472", "class_list": "", "function": "Probable hormone (Probable). Promotes chemotaxis in myeloid cells (By similarity)., [UniProtKB, UniProtKB]; Resistin-like molecule beta acts as a mitogenic factor in hypoxic pulmonary hypertension via the Ca(2+)-dependent PI3K/Akt/mTOR and PKC/MAPK signaling pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Revealed a repression of RELMgamma mRNA in nasal respiratory epithelium of cigarette smoke-exposed versus untreated rats; tissue-specific expression revealed highest expression in hematopoietic tissues, suggesting a cytokine-like role for RELMgamma, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TN86", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3V686-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70564-1", "uniprot_id": [ { "id": "SPB5_RAT", "url": "https://www.uniprot.org/uniprot/P70564", "type": "external" } ], "mass": 42063.0, "length": 375, "protein_name": "Serpin B5", "gene_name": "Serpinb5", "organism": "Rat", "refseq_name": "serpin B5", "refseq_ac": [ { "id": "NP_476449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476449", "type": "external" } ], "gene_names_uniprotkb": "Serpinb5; Pi5", "gene_names_refseq": "Maspin; PI-5; Pi5; Serpinb5", "protein_names_uniprotkb": "Serpin B5; Maspin; PI-5; Peptidase inhibitor 5", "protein_names_refseq": "peptidase inhibitor 5; protease inhibitor 5; serine (or cysteine) peptidase inhibitor, clade B, member 5; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; serpin B5; serpin peptidase inhibitor, clade B (ovalbumin), member 5", "tax_id": 10116, "disease": "alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:116589)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "17563239;17950367;21069375;32746986;34059749;9065806", "class_list": "", "function": "During rat tooth development, maspin expression was observed for the first time in inner and outer enamel epithelial cells and dental papilla cells at early bell stage., [RefSeq, PubMed]; Maspin expressed in active osteoblasts plays an important physiological role during maturation of the bone matrix, and in particular, during the process of accumulation of latent TGF-beta in the extracellular matrix, [RefSeq, PubMed]; Results show that VACM-1 protein regulates endothelial cell growth and may modulate angiogenesis by a mechanism that involves MAPK phosphorylation and maspin expression., [RefSeq, PubMed]; Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; The potential function of IKKalpha in gastric precancerous lesion via mediating Maspin., [RefSeq, PubMed]; Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0045177 apical part of cell;GO:0001533 cornified envelope", "go_biological_process": "GO:0050678 regulation of epithelial cell proliferation;GO:0030198 extracellular matrix organization;GO:0002009 morphogenesis of an epithelium;GO:0060512 prostate gland morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P70564-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51672-1", "uniprot_id": [ { "id": "XCL1_RAT", "url": "https://www.uniprot.org/uniprot/P51672", "type": "external" } ], "mass": 12370.0, "length": 114, "protein_name": "Lymphotactin", "gene_name": "Xcl1", "organism": "Rat", "refseq_name": "lymphotactin precursor", "refseq_ac": [ { "id": "NP_599188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599188", "type": "external" } ], "gene_names_uniprotkb": "Xcl1; Ltn; Scyc1", "gene_names_refseq": "Ltn; Scyc1; Xcl1", "protein_names_uniprotkb": "Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Small-inducible cytokine C1", "protein_names_refseq": "c motif chemokine 1; chemokine (C motif) ligand 1; cytokine SCM-1; lymphotactin precursor; lymphotactin; small inducible cytokine subfamily C, member 1 (lymphotactin); small-inducible cytokine C1", "tax_id": 10116, "disease": "anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780)", "pathway": " (rno:171371); (R-RNO-380108); (R-RNO-416476)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "24155383;29588250;31649144", "class_list": "", "function": "Biology of vXCL1 offers an interesting opportunity to study the role of XCL1 and XCR1(+) DC in the cross-presentation of viral antigens, [RefSeq, PubMed]; Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rat cytomegalovirus-encoded gamma-chemokine vXCL1 is a highly adapted, species-specific agonist for rat XCR1-positive dendritic cells. Publication Status: Online-Only, [RefSeq, PubMed]; XCR1 is upregulated at sites of trigeminal nerve injury with a time course that correlates with the development of spontaneous activity at these sites. Exposure of trigeminal brainstem tissue to XCL1 induces expression of c-Fos, pERK and pp38 immunolabeling in trigeminal subnucleus caudalis, and induces increased spontaneous low-threshold activity indicative of hyperexcitability within nociceptive circuitry., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008009 chemokine activity;GO:0042379 chemokine receptor binding;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002725 negative regulation of T cell cytokine production;GO:0032703 negative regulation of interleukin-2 production;GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51672-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08435-1", "uniprot_id": [ { "id": "TKNK_RAT", "url": "https://www.uniprot.org/uniprot/P08435", "type": "external" } ], "mass": 12660.0, "length": 116, "protein_name": "Tachykinin-3", "gene_name": "Tac3", "organism": "Rat", "refseq_name": "tachykinin-3 precursor", "refseq_ac": [ { "id": "NP_062035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062035", "type": "external" } ], "gene_names_uniprotkb": "Tac3; Nknb; Tac2", "gene_names_refseq": "Tac2; Tac3", "protein_names_uniprotkb": "Tachykinin-3; Neuromedin-K", "protein_names_refseq": "neurokinin B; tachykinin 2; tachykinin 3; tachykinin-3 precursor", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 10 with or without anosmia (Disease Ontology:DOID:0090089); hypertension (Disease Ontology:DOID:10763); persistent fetal circulation syndrome (Disease Ontology:DOID:13042)", "pathway": " (rno:29191); (R-RNO-380095); (R-RNO-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "1370820;24863620;25051440;25490143;29203206;30224608;3479225", "class_list": "", "function": "At the onset of puberty, the densities of kisspeptin and neurokinin B IR cells were significantly higher in the high-fat diet group than in the control group, [RefSeq, PubMed]; Data suggest that endogenous NeuroKinin B-Neurokinin 3 Receptor signalling plays a role in controlling the timing of puberty., [RefSeq, PubMed]; Is a ligand for TACR3, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C. Binding to TACR3 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP). Is a critical central regulator of gonadal function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]; NKB agonist stimulates FSH secretion in a strikingly developmental-dependent manner, [RefSeq, PubMed]; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The divergent regulation of kisspeptin and NKB peptide contents in the arcuate nucleus as a function of sex and steroid milieu enlarge our understanding on how these neuropeptides are posttranscriptionally regulated in KNDy neurons., [RefSeq, PubMed]; The expressions of each mRNA (Kiss1, Tac3, and Pdyn) and each peptide (kisspeptin, NKB, and DynA) in the ARC significantly decreased in Zucker fatty rats compared with Zucker lean rats, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031837 substance K receptor binding;GO:0048018 receptor ligand activity;GO:0031836 neuromedin K receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0045777 positive regulation of blood pressure;GO:1902093 positive regulation of flagellated sperm motility;GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P08435-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70483-1", "uniprot_id": [ { "id": "STRN_RAT", "url": "https://www.uniprot.org/uniprot/P70483", "type": "external" } ], "mass": 86226.0, "length": 780, "protein_name": "Striatin", "gene_name": "Strn", "organism": "Rat", "refseq_name": "striatin", "refseq_ac": [ { "id": "NP_062021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062021", "type": "external" } ], "gene_names_uniprotkb": "Strn", "gene_names_refseq": "Strn", "protein_names_uniprotkb": "Striatin", "protein_names_refseq": "striatin, calmodulin binding protein; striatin", "tax_id": 10116, "disease": "", "pathway": " (rno:29149); (R-RNO-1257604); (R-RNO-6811558); (R-RNO-9009391)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "22673903;23015759;28825318;31565882;8769426", "class_list": "", "function": "Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study demonstrating that aldosterone rapidly enhances renal levels of striatin and caveolin-1 (cav-1). Aldosterone increases striatin levels via an mineralocorticoid receptor (MR)-independent pathway, whereas cav-1 is partially regulated through MR., [RefSeq, PubMed]; Suggest a novel role for striatin in regulating cardiomyocyte spontaneous contraction rate and the dynamics of the STRN/caveolin-3/calmodulin complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0048306 calcium-dependent protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005923 bicellular tight junction;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0007626 locomotory behavior;GO:0008285 negative regulation of cell population proliferation;GO:0016358 dendrite development;GO:0016055 Wnt signaling pathway;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70483-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01717-1", "uniprot_id": [ { "id": "TRHR_RAT", "url": "https://www.uniprot.org/uniprot/Q01717", "type": "external" } ], "mass": 46609.0, "length": 412, "protein_name": "Thyrotropin-releasing hormone receptor", "gene_name": "Trhr", "organism": "Rat", "refseq_name": "thyrotropin-releasing hormone receptor", "refseq_ac": [ { "id": "NP_037179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037179", "type": "external" } ], "gene_names_uniprotkb": "Trhr", "gene_names_refseq": "Trhr", "protein_names_uniprotkb": "Thyrotropin-releasing hormone receptor; TRH-R; Thyroliberin receptor", "protein_names_refseq": "TRH-R; thyroliberin receptor; thyrotropin-releasing hormone receptor", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); congenital nongoitrous hypothyroidism 7 (Disease Ontology:DOID:0111836); hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:25570); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "1317787;1334485;1338727;1373613;1377915;15905217;15944919;16257458;18795335;20691166;7509436;8275956;8387312", "class_list": "", "function": "Co-localization of LepRb and TRHR1 is not observed on individual fibers in the hindbrain, but these two fiber types co-mingle in vagal and reticular nuclei., [RefSeq, PubMed]; Data provide new evidence for a novel intrathyroidal regulatory pathway of thyroid hormone secretion via paracrine/autocrine TRH signaling., [RefSeq, PubMed]; Our results demonstrate that whereas the TRH receptor uses a G(q/11) protein for transducing the Ca2+ signal during the initial response to TRH, this G-protein is not involved in the TRH-induced inhibition of endogenous r-ERG currents in pituitary cells., [RefSeq, PubMed]; Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway., [UniProtKB, UniProtKB]; Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway., [UniProtKB, UniProtKB]; The expression and localization of TRH-R1 and TRH-R2 in postnatal development and ethane dimethane sulfonate treated rat testes were observed., [RefSeq, PubMed]; These data suggest that the proposed disulfide bond of proTRH is involved in sorting of proTRH-derived peptides and in their retention within maturing secretory granules., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q63948;Q63949", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004997 thyrotropin-releasing hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0031334 positive regulation of protein-containing complex assembly;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q01717-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07116-1", "uniprot_id": [ { "id": "SUOX_RAT", "url": "https://www.uniprot.org/uniprot/Q07116", "type": "external" } ], "mass": 60806.0, "length": 546, "protein_name": "Sulfite oxidase, mitochondrial", "gene_name": "Suox", "organism": "Rat", "refseq_name": "sulfite oxidase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_112389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112389", "type": "external" } ], "gene_names_uniprotkb": "Suox", "gene_names_refseq": "Suox", "protein_names_uniprotkb": "Sulfite oxidase, mitochondrial; 1.7.-.-; 1.8.3.1; Nitrite reductase, mitochondrial", "protein_names_refseq": "sulfite oxidase, mitochondrial precursor; sulfite oxidase, mitochondrial", "tax_id": 10116, "disease": "isolated sulfite oxidase deficiency (Disease Ontology:DOID:0111270); inherited metabolic disorder (Disease Ontology:DOID:655); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:81805); (R-RNO-1614517)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12763039;17613108;2249998;3393528;38041814;6181785;8276806", "class_list": "", "function": "Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Results suggest that hippocampus antioxidant enzymes (defense mechanism against the oxidative challenge) are up-regulated by ingested sulfites in sulfite oxidase competent rats., [RefSeq, PubMed]; Sulfite oxidase gene expression in brain and in other tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6W0", "ec_number_list": [ { "id": "1.8.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.1", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" } ], "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0020037 heme binding;GO:0043546 molybdopterin cofactor binding;GO:0008482 sulfite oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0007584 response to nutrient;GO:0006790 sulfur compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q07116-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70708-1", "uniprot_id": [ { "id": "PADI3_RAT", "url": "https://www.uniprot.org/uniprot/P70708", "type": "external" } ], "mass": 75038.0, "length": 664, "protein_name": "Protein-arginine deiminase type-3", "gene_name": "Padi3", "organism": "Rat", "refseq_name": "protein-arginine deiminase type-3", "refseq_ac": [ { "id": "NP_058926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058926", "type": "external" } ], "gene_names_uniprotkb": "Padi3; Pad3; Pdi3", "gene_names_refseq": "Padi3; Pdi3", "protein_names_uniprotkb": "Protein-arginine deiminase type-3; 3.5.3.15; Peptidylarginine deiminase III; Protein-arginine deiminase type III", "protein_names_refseq": "peptidyl arginine deiminase, type 3; peptidyl arginine deiminase, type III; peptidylarginine deiminase III; protein-arginine deiminase type III; protein-arginine deiminase type-3", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:29520); (R-RNO-3247509)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9192727", "class_list": "", "function": "Catalyzes the deimination of arginine residues of proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" } ], "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0019546 L-arginine deiminase pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P70708-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55035-1", "uniprot_id": [ { "id": "PPIG_RAT", "url": "https://www.uniprot.org/uniprot/O55035", "type": "external" } ], "mass": 88379.0, "length": 752, "protein_name": "Peptidyl-prolyl cis-trans isomerase G", "gene_name": "Ppig", "organism": "Rat", "refseq_name": "peptidyl-prolyl cis-trans isomerase G", "refseq_ac": [ { "id": "NP_113981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113981", "type": "external" } ], "gene_names_uniprotkb": "Ppig", "gene_names_refseq": "Ppig", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase G; 5.2.1.8; Cyclophilin G; Matrin cyclophilin; Matrin-cyp; PPIase G; Peptidyl-prolyl isomerase G; Rotamase G", "protein_names_refseq": "PPIase G; cyclophilin G; matrin cyclophilin (matrin-cyp); matrin-cyp; peptidyl-prolyl cis-trans isomerase G; peptidyl-prolyl isomerase G; rotamase G", "tax_id": 10116, "disease": "", "pathway": " (rno:83624); (R-RNO-72163)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16641100;22673903;9525923", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U346", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O55035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55094-1", "uniprot_id": [ { "id": "NR2C2_RAT", "url": "https://www.uniprot.org/uniprot/P55094", "type": "external" } ], "mass": 65344.0, "length": 596, "protein_name": "Nuclear receptor subfamily 2 group C member 2", "gene_name": "Nr2c2", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 2 group C member 2", "refseq_ac": [ { "id": "NP_059019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059019", "type": "external" } ], "gene_names_uniprotkb": "Nr2c2; Tr4", "gene_names_refseq": "Nr2c2; Tr4", "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TR4; Testicular receptor 4", "protein_names_refseq": "TR4 orphan receptor; TR4-NS orphan receptor; nuclear receptor subfamily 2 group C member 2; orphan nuclear receptor TR4; orphan receptor TR4; testicular receptor 4", "tax_id": 10116, "disease": "", "pathway": " (rno:50659); (R-RNO-383280); (R-RNO-9940951)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "22673903;36280014;8016112;9556573", "class_list": "", "function": "Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity)., [UniProtKB]; Testicular orphan receptor 4 induced hepatic stellate cells activation via the regulation of TGF-beta receptor /Smad2/3 signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0048520 positive regulation of behavior;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55094-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8C7-1", "uniprot_id": [ { "id": "PRKRA_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8C7", "type": "external" } ], "mass": 34355.0, "length": 313, "protein_name": "Interferon-inducible double-stranded RNA-dependent protein kinase activator A", "gene_name": "Prkra", "organism": "Rat", "refseq_name": "interferon-inducible double-stranded RNA-dependent protein kinase activator A", "refseq_ac": [ { "id": "NP_001019951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019951", "type": "external" } ], "gene_names_uniprotkb": "Prkra", "gene_names_refseq": "Prkra; RAX", "protein_names_uniprotkb": "Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator", "protein_names_refseq": "PKR associated protein X; interferon-inducible double-stranded RNA-dependent protein kinase activator A; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double-stranded RNA-dependent activator", "tax_id": 10116, "disease": "dystonia 16 (Disease Ontology:DOID:0090048)", "pathway": " (rno:311130); (R-RNO-203927); (R-RNO-426486); (R-RNO-9833482)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "16396499;22673903;27987116;35421805", "class_list": "", "function": "Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association, sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). May function as regulator of gastric epithelial differentiation (By similarity)., [UniProtKB, UniProtKB]; Inhibiting the aberrant PACT-p53 axis activation ameliorates spinal cord ischaemia-reperfusion injury in rats., [RefSeq, PubMed]; PKR regulates bone metabolism in vitro and in vivo. Review article, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0006468 protein phosphorylation;GO:0008284 positive regulation of cell population proliferation;GO:0050821 protein stabilization;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4V8C7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7L5-1", "uniprot_id": [ { "id": "PO4F2_RAT", "url": "https://www.uniprot.org/uniprot/G3V7L5", "type": "external" } ], "mass": 43230.0, "length": 412, "protein_name": "POU domain, class 4, transcription factor 2", "gene_name": "Pou4f2", "organism": "Rat", "refseq_name": "POU domain, class 4, transcription factor 2", "refseq_ac": [ { "id": "NP_599182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599182", "type": "external" } ], "gene_names_uniprotkb": "Pou4f2; Brn3b", "gene_names_refseq": "Brn-3.2; Brn-3B; Brn3b; Pou4f2", "protein_names_uniprotkb": "POU domain, class 4, transcription factor 2; Brain-3B; Brain-specific homeobox/POU domain protein 3B; Brn-3.2; Brn-3B", "protein_names_refseq": "POU domain, class 4, transcription factor 2; brain-3B; brain-specific homeobox/POU domain protein 3B", "tax_id": 10116, "disease": "", "pathway": " (rno:171355); (R-RNO-6804759)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "18368538;25786379;29393594;31413277;8835784", "class_list": "", "function": "A potential role for Brn-3b in neurodegenerative diseases in which hypoxia/ischemia contribute to pathophysiology of the disease., [RefSeq, PubMed]; Hearts from male Brn-3b KO mutant mice display contractile dysfunction at baseline but also attenuated hypertrophic responses to AngII treatment. Hearts from AngII-treated male Brn-3b KO mice develop further contractile dysfunction linked to extensive fibrosis/remodelling. Publication Status: Online-Only, [RefSeq, PubMed]; Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex;GO:0000791 euchromatin", "go_biological_process": "GO:1902870 negative regulation of amacrine cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "G3V7L5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28075-1", "uniprot_id": [ { "id": "PSB5_RAT", "url": "https://www.uniprot.org/uniprot/P28075", "type": "external" } ], "mass": 28585.0, "length": 263, "protein_name": "Proteasome subunit beta type-5", "gene_name": "Psmb5", "organism": "Rat", "refseq_name": "proteasome subunit beta type-5", "refseq_ac": [ { "id": "NP_001099197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099197", "type": "external" } ], "gene_names_uniprotkb": "Psmb5", "gene_names_refseq": "Psmb5", "protein_names_uniprotkb": "Proteasome subunit beta type-5; 3.4.25.1; Macropain epsilon chain; Multicatalytic endopeptidase complex epsilon chain; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit X; Proteasome subunit beta-5; beta-5", "protein_names_refseq": "beta-5; macropain epsilon chain; multicatalytic endopeptidase complex epsilon chain; proteasome (prosome, macropain) subunit, beta type 5; proteasome beta 5 subunit; proteasome beta type subunit 5; proteasome chain 6; proteasome epsilon chain; proteasome subunit X; proteasome subunit beta 5; proteasome subunit beta type-5", "tax_id": 10116, "disease": "proteasome-associated autoinflammatory syndrome 1 (Disease Ontology:DOID:0050553); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:29425); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 57, "publication_count": 3, "publication_id_list": "16988215;21059646;2335214", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; In cells overexpressing wild type and E50K optineurin, the level of PSMB5, indicative of proteasome activity, was reduced, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "4.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.17", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0008233 peptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P28075-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54735-1", "uniprot_id": [ { "id": "PDE5A_RAT", "url": "https://www.uniprot.org/uniprot/O54735", "type": "external" } ], "mass": 94556.0, "length": 833, "protein_name": "cGMP-specific 3',5'-cyclic phosphodiesterase", "gene_name": "Pde5a", "organism": "Rat", "refseq_name": "cGMP-specific 3',5'-cyclic phosphodiesterase", "refseq_ac": [ { "id": "NP_598268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598268", "type": "external" } ], "gene_names_uniprotkb": "Pde5a; Pde5", "gene_names_refseq": "PDE5A2; Pde5a", "protein_names_uniprotkb": "cGMP-specific 3',5'-cyclic phosphodiesterase; 3.1.4.35; CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase", "protein_names_refseq": "CGB-PDE; cGMP-binding cGMP specific phosphodiesterase 5A2; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; phosphodiesterase 5A, cGMP-specific; phosphodiesterase type 5", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); pre-eclampsia (Disease Ontology:DOID:10591); primary biliary cholangitis (Disease Ontology:DOID:12236); impotence (Disease Ontology:DOID:1875); IgA glomerulonephritis (Disease Ontology:DOID:2986); vasculogenic impotence (Disease Ontology:DOID:4762); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:171115); (R-RNO-418457); (R-RNO-445355); (R-RNO-9013422)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "12466227;24068049;26657792;32311453;33009887;9370351", "class_list": "", "function": "Changes in the expression and function of the PDE5 pathway in the obstructed urinary bladder., [RefSeq, PubMed]; Differential expression of caveolin-1 during pathogenesis of combined pulmonary fibrosis and emphysema: Effect of phosphodiesterase-5 inhibitor., [RefSeq, PubMed]; MRNA transcript and protein levels of PDE5 in the main and first branch of the pulmonary arteries are increased by chronic hypoxia., [RefSeq, PubMed]; Our data showed a significant and previously undocumented upregulation of PDE5 in both rat and human BPH. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The effects of vasodilation on plasma volume expansionhemodilution, and PDE5A expression via the renin-angiotensin-aldosterone system are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004112 cyclic-nucleotide phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0060282 positive regulation of oocyte development;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O54735-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70555-1", "uniprot_id": [ { "id": "PTH2R_RAT", "url": "https://www.uniprot.org/uniprot/P70555", "type": "external" } ], "mass": 61804.0, "length": 546, "protein_name": "Parathyroid hormone 2 receptor", "gene_name": "Pth2r", "organism": "Rat", "refseq_name": "parathyroid hormone 2 receptor precursor", "refseq_ac": [ { "id": "NP_112351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112351", "type": "external" } ], "gene_names_uniprotkb": "Pth2r; Pthr2", "gene_names_refseq": "Pth2r; Pthr2", "protein_names_uniprotkb": "Parathyroid hormone 2 receptor; PTH2 receptor", "protein_names_refseq": "PTH2 receptor; parathyroid hormone 2 receptor precursor; parathyroid hormone receptor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:81753); (R-RNO-373080)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14988434;15677763;8828488", "class_list": "", "function": "Results suggest that an inhibition of endogenous nitric oxide production unmasks a profound negative inotropic effect of tuberoinfundibular peptide (TIP39) that is mediated by an activation of the parathyroid hormone receptor 2, [RefSeq, PubMed]; Specific interactions within the ligand-receptor bimolecular complex mediate distinct postactivation responses of class II G protein- coupled receptors and provide novel insights into the physiological regulation of PTH2R activity, [RefSeq, PubMed]; This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004991 parathyroid hormone receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P70555-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1I4-1", "uniprot_id": [ { "id": "PRRC1_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1I4", "type": "external" } ], "mass": 46279.0, "length": 443, "protein_name": "Protein PRRC1", "gene_name": "Prrc1", "organism": "Rat", "refseq_name": "protein PRRC1", "refseq_ac": [ { "id": "NP_001029059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029059", "type": "external" } ], "gene_names_uniprotkb": "Prrc1", "gene_names_refseq": "Prcc1; Prrc1", "protein_names_uniprotkb": "Protein PRRC1; Proline-rich and coiled-coil-containing protein 1", "protein_names_refseq": "proline-rich and coiled-coil-containing protein 1; protein PRRC1", "tax_id": 10116, "disease": "", "pathway": " (rno:291444)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34502162", "class_list": "", "function": "May act as a regulator of the protein kinase A (PKA) during embryonic development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8I6G4Z0", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0010669 epithelial structure maintenance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q3T1I4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55018-1", "uniprot_id": [ { "id": "S12A3_RAT", "url": "https://www.uniprot.org/uniprot/P55018", "type": "external" } ], "mass": 110554.0, "length": 1002, "protein_name": "Solute carrier family 12 member 3", "gene_name": "Slc12a3", "organism": "Rat", "refseq_name": "solute carrier family 12 member 3", "refseq_ac": [ { "id": "NP_062218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062218", "type": "external" } ], "gene_names_uniprotkb": "Slc12a3; Tsc", "gene_names_refseq": "NCC; Slc12a3; TSC", "protein_names_uniprotkb": "Solute carrier family 12 member 3; Na-Cl symporter; Thiazide-sensitive sodium-chloride cotransporter", "protein_names_refseq": "Na-Cl symporter; solute carrier family 12 (sodium/chloride transporter), member 3; solute carrier family 12 (sodium/chloride transporters), member 3; solute carrier family 12 member 3; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter", "tax_id": 10116, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); hypogonadotropic hypogonadism 6 with or without anosmia (Disease Ontology:DOID:0090086); essential hypertension (Disease Ontology:DOID:10825); hypospadias (Disease Ontology:DOID:10892); prostatic hypertrophy (Disease Ontology:DOID:11132); DiGeorge syndrome (Disease Ontology:DOID:11198); breast cancer (Disease Ontology:DOID:1612); epilepsy (Disease Ontology:DOID:1826); endodermal sinus tumor (Disease Ontology:DOID:1911); embryonal carcinoma (Disease Ontology:DOID:3308); choriocarcinoma (Disease Ontology:DOID:3594); tetralogy of Fallot (Disease Ontology:DOID:6419); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:54300); (R-RNO-426117)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10894798;12538726;16887815;28003191;28356292;29767556;29846116;36961378;8021284", "class_list": "", "function": "Direct epithelial action of calcineurin inhibitor cyclosporine A is sufficient for the activation of renal NCC., [RefSeq, PubMed]; Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:10894798, PubMed:16887815, PubMed:8021284). Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, UniProtKB]; Kidney-specific WNK1 isoform is a potent activator of WNK4 and NCC-mediated sodium/chloride transport., [RefSeq, PubMed]; Kidneys respond acutely to hyperkalemic challenges by decreasing the activity of NCC while increasing that of ENaC., [RefSeq, PubMed]; Renal CD81 interacts with sodium potassium 2 chloride cotransporter and sodium chloride cotransporter in rats with lipopolysaccharide-induced preeclampsia., [RefSeq, PubMed]; The presence of active plasmin in urine in hydronephrosis could cause abnormal proteolytic activation of ENaC-gamma and impaired ability to excrete Na via NCC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 2, "mined_n_glycosites": 2, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0015081 sodium ion transmembrane transporter activity;GO:0015378 sodium:chloride symporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane;GO:0031982 vesicle", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:0006821 chloride transport;GO:1902476 chloride transmembrane transport;GO:0035725 sodium ion transmembrane transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P55018-1", "record_type": "protein", "filter_code": "0000000.1100111.010000.000000000000001000.1000100000001.110.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJ92-1", "uniprot_id": [ { "id": "PP4C_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJ92", "type": "external" } ], "mass": 35068.0, "length": 307, "protein_name": "Serine/threonine-protein phosphatase 4 catalytic subunit", "gene_name": "Ppp4c", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 4 catalytic subunit isoform 1", "refseq_ac": [ { "id": "NP_599186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599186", "type": "external" } ], "gene_names_uniprotkb": "Ppp4c", "gene_names_refseq": "Ppp4c; Ppx", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 catalytic subunit; 3.1.3.16; PP4C; Pp4", "protein_names_refseq": "PP4C; pp4; protein phosphatase 4 (formerly X), catalytic subunit; serine/threonine-protein phosphatase 4 catalytic subunit isoform 1; serine/threonine-protein phosphatase 4 catalytic subunit", "tax_id": 10116, "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515)", "pathway": " (rno:171366); (R-RNO-5693607)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "37530343", "class_list": "", "function": "Expression of protein phosphatase 4 in different tissues under hypoxia., [RefSeq, PubMed]; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0044877 protein-containing complex binding;GO:0005521 lamin binding;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0016311 dephosphorylation;GO:0001933 negative regulation of protein phosphorylation;GO:0000724 double-strand break repair via homologous recombination;GO:0071347 cellular response to interleukin-1;GO:0010569 regulation of double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJ92-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34067-1", "uniprot_id": [ { "id": "PSB4_RAT", "url": "https://www.uniprot.org/uniprot/P34067", "type": "external" } ], "mass": 29197.0, "length": 263, "protein_name": "Proteasome subunit beta type-4", "gene_name": "Psmb4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Psmb4", "gene_names_refseq": "", "protein_names_uniprotkb": "Proteasome subunit beta type-4; Macropain beta chain; Multicatalytic endopeptidase complex beta chain; Proteasome beta chain; Proteasome chain 3; Proteasome subunit beta-7; RN3; beta-7", "protein_names_refseq": "", "tax_id": 10116, "disease": "proteasome-associated autoinflammatory syndrome 3 (Disease Ontology:DOID:0060916)", "pathway": " (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 57, "publication_count": 4, "publication_id_list": "16483544;2335214;8482379;8645151", "class_list": "", "function": "Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P28071;P97719", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0002862 negative regulation of inflammatory response to antigenic stimulus;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P34067-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7D5-1", "uniprot_id": [ { "id": "RASF2_RAT", "url": "https://www.uniprot.org/uniprot/Q3B7D5", "type": "external" } ], "mass": 38021.0, "length": 326, "protein_name": "Ras association domain-containing protein 2", "gene_name": "Rassf2", "organism": "Rat", "refseq_name": "ras association domain-containing protein 2", "refseq_ac": [ { "id": "NP_001032173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032173", "type": "external" } ], "gene_names_uniprotkb": "Rassf2", "gene_names_refseq": "Rassf2", "protein_names_uniprotkb": "Ras association domain-containing protein 2", "protein_names_refseq": "Ras association (RalGDS/AF-6) domain family 2; Ras association (RalGDS/AF-6) domain family member 2; ras association domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:311437)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000776 kinetochore", "go_biological_process": "GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0045860 positive regulation of protein kinase activity;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3B7D5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V9H8-1", "uniprot_id": [ { "id": "RET_RAT", "url": "https://www.uniprot.org/uniprot/G3V9H8", "type": "external" } ], "mass": 124237.0, "length": 1115, "protein_name": "Proto-oncogene tyrosine-protein kinase receptor Ret", "gene_name": "Ret", "organism": "Rat", "refseq_name": "proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor", "refseq_ac": [ { "id": "NP_036775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036775", "type": "external" } ], "gene_names_uniprotkb": "Ret", "gene_names_refseq": "Ret", "protein_names_uniprotkb": "Proto-oncogene tyrosine-protein kinase receptor Ret; 2.7.10.1", "protein_names_refseq": "Ret gene for receptor tyrosin; Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease); proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor; proto-oncogene tyrosine-protein kinase receptor Ret; receptor tyrosine kinase", "tax_id": 10116, "disease": "multiple endocrine neoplasia type 2A (Disease Ontology:DOID:0050430); familial medullary thyroid carcinoma (Disease Ontology:DOID:0050547); pheochromocytoma (Disease Ontology:DOID:0050771); stroke (Disease Ontology:DOID:0051061); renal hypoplasia (Disease Ontology:DOID:0080204); Parkinsonism (Disease Ontology:DOID:0080855); multiple endocrine neoplasia type 2B (Disease Ontology:DOID:10016); Hirschsprung's disease (Disease Ontology:DOID:10487); clubfoot (Disease Ontology:DOID:11836); carotid stenosis (Disease Ontology:DOID:13001); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); brain ischemia (Disease Ontology:DOID:2316); coronary artery disease (Disease Ontology:DOID:3393); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24716); (R-RNO-5673001); (R-RNO-8853659)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11328649;18753381;23333276;28846099;29018141;30541958;34273501;37178997", "class_list": "", "function": "Differential expression of RET and GDNF family receptor, GFR-alpha1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling., [RefSeq, PubMed]; GDNF requires HIF-1alpha and RET activation for suppression of programmed cell death of enteric neurons by metabolic challenge., [RefSeq, PubMed]; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation in response to glia cell line-derived growth family factors (GDNF, NRTN, ARTN, PSPN and GDF15) (By similarity). In contrast to most receptor tyrosine kinases, RET requires not only its cognate ligands but also coreceptors, for activation (By similarity). GDNF ligands (GDNF, NRTN, ARTN, PSPN and GDF15) first bind their corresponding GDNFR coreceptors (GFRA1, GFRA2, GFRA3, GFRA4 and GFRAL, respectively), triggering RET autophosphorylation and activation, leading to activation of downstream signaling pathways, including the MAPK- and AKT-signaling pathways (PubMed:23333276). Acts as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF (By similarity). Required for the molecular mechanisms orchestration during intestine organogenesis via the ARTN-GFRA3 signaling: involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (By similarity). Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (By similarity). Also active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage (By similarity). Triggers the differentiation of rapidly adapting (RA) mechanoreceptors (By similarity). Involved in the development of the neural crest (By similarity). Regulates nociceptor survival and size (By similarity). Phosphorylates PTK2/FAK1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The findings demonstrate that elevated GDNF levels can reduce the retinal injury, whereby down-regulated miR-216a aggravates the YAG laser-induced retinal injury by targeting the GDNF level through the GDNF/GFRa1/RET signaling pathway., [RefSeq, PubMed]; The inverse relationship between GFRalpha1 and C-Ret, as knocking down C-Ret led to increases in GFRalpha1 expression., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q9EPA1;Q9EPC3", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0060384 innervation;GO:0048484 enteric nervous system development;GO:0001838 embryonic epithelial tube formation;GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "G3V9H8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q562B5-1", "uniprot_id": [ { "id": "PGAM5_RAT", "url": "https://www.uniprot.org/uniprot/Q562B5", "type": "external" } ], "mass": 32060.0, "length": 288, "protein_name": "Serine/threonine-protein phosphatase PGAM5, mitochondrial", "gene_name": "Pgam5", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001020443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020443", "type": "external" } ], "gene_names_uniprotkb": "Pgam5", "gene_names_refseq": "Pgam5; RGD1312028", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PGAM5, mitochondrial; 3.1.3.16; Phosphoglycerate mutase family member 5", "protein_names_refseq": "phosphoglycerate mutase family member 5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1; serine/threonine-protein phosphatase PGAM5, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:288731); (R-RNO-8934903); (R-RNO-9861718)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "22265414;27815660;32580628;33681349;38142589;38818468;38843836", "class_list": "", "function": "LPS induces cardiomyocyte necroptosis through the Ripk3/Pgam5 signaling pathway., [RefSeq, PubMed]; MiR-21-5p Suppresses Mitophagy to Alleviate Hyperoxia-Induced Acute Lung Injury by Directly Targeting PGAM5. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy. Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1. Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation. Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3. Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (By similarity). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; PGAM5 controls cardiomyocyte apoptosis induced by MIRI through regulating Keap1-mediated Bcl-xL degradation, which may supply a novel molecular target for acute myocardial infarction (AMI) therapy., [RefSeq, PubMed]; Pgam5 aggravates hyperglycemia-induced myocardial dysfunction through disrupting Phb2-dependent mitochondrial dynamics. Publication Status: Online-Only, [RefSeq, PubMed]; Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "1.1.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.40", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0090141 positive regulation of mitochondrial fission;GO:0070266 necroptotic process;GO:0120163 negative regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q562B5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1H5-1", "uniprot_id": [ { "id": "TYDP2_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1H5", "type": "external" } ], "mass": 40793.0, "length": 366, "protein_name": "Tyrosyl-DNA phosphodiesterase 2", "gene_name": "Tdp2", "organism": "Rat", "refseq_name": "tyrosyl-DNA phosphodiesterase 2", "refseq_ac": [ { "id": "NP_001030119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030119", "type": "external" } ], "gene_names_uniprotkb": "Tdp2; Ttrap", "gene_names_refseq": "Tdp2; Ttrap", "protein_names_uniprotkb": "Tyrosyl-DNA phosphodiesterase 2; 3.1.4.-; 5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor-associated protein; Tyr-DNA phosphodiesterase 2", "protein_names_refseq": "5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor-associated protein; Traf and Tnf receptor associated protein; tyr-DNA phosphodiesterase 2; tyrosyl-DNA phosphodiesterase 2", "tax_id": 10116, "disease": "autosomal recessive spinocerebellar ataxia 23 (Disease Ontology:DOID:0111613)", "pathway": " (rno:498749); (R-RNO-5693571)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0003697 single-stranded DNA binding;GO:0004518 nuclease activity;GO:0036317 tyrosyl-RNA phosphodiesterase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006302 double-strand break repair;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q3T1H5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88370-1", "uniprot_id": [ { "id": "PI42C_RAT", "url": "https://www.uniprot.org/uniprot/O88370", "type": "external" } ], "mass": 47049.0, "length": 420, "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "gene_name": "Pip4k2c", "organism": "Rat", "refseq_name": "phosphatidylinositol 5-phosphate 4-kinase type-2 gamma", "refseq_ac": [ { "id": "NP_536728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536728", "type": "external" } ], "gene_names_uniprotkb": "Pip4k2c; Pip5k2c", "gene_names_refseq": "Pip4k2c; Pip5k2c", "protein_names_uniprotkb": "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; 2.7.1.149; PI(5)P 4-kinase type II gamma; PIP4KII-gamma; Phosphatidylinositol 5-phosphate 4-kinase type II gamma", "protein_names_refseq": "PI(5)P 4-kinase type II gamma; PIP4KII-gamma; phosphatidylinositol 5-phosphate 4-kinase type II gamma; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; phosphatidylinositol-4-phosphate 5-kinase, type II, gamma", "tax_id": 10116, "disease": "", "pathway": " (rno:140607); (R-RNO-1660499); (R-RNO-6811555); (R-RNO-6811558); (R-RNO-8847453)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "9685379", "class_list": "", "function": "Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity (PubMed:9685379). May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity (By similarity). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" } ], "go_molecular_function": "GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005776 autophagosome", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0010506 regulation of autophagy;GO:0006661 phosphatidylinositol biosynthetic process;GO:2000786 positive regulation of autophagosome assembly;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O88370-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "I6L9G5-1", "uniprot_id": [ { "id": "RCN3_RAT", "url": "https://www.uniprot.org/uniprot/I6L9G5", "type": "external" } ], "mass": 37942.0, "length": 328, "protein_name": "Reticulocalbin-3", "gene_name": "Rcn3", "organism": "Rat", "refseq_name": "reticulocalbin-3 precursor", "refseq_ac": [ { "id": "NP_001008694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008694", "type": "external" } ], "gene_names_uniprotkb": "Rcn3", "gene_names_refseq": "Rcn3; Rem1; Rlp49", "protein_names_uniprotkb": "Reticulocalbin-3", "protein_names_refseq": "reticulocalbin 3, EF-hand calcium binding domain; reticulocalbin-3 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:494125)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16433634;29393594", "class_list": "", "function": "Ectopic expression of the human RCN3 ortholog in rat GH4C1 cells, and demonstration that it increases the autoactivation and secretion of rat PACE4., [RefSeq, PubMed]; Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (By similarity). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0015031 protein transport;GO:0043129 surfactant homeostasis;GO:0055091 phospholipid homeostasis;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "I6L9G5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2M2R8-1", "uniprot_id": [ { "id": "PEX5_RAT", "url": "https://www.uniprot.org/uniprot/Q2M2R8", "type": "external" } ], "mass": 71022.0, "length": 640, "protein_name": "Peroxisomal targeting signal 1 receptor", "gene_name": "Pex5", "organism": "Rat", "refseq_name": "peroxisomal targeting signal 1 receptor", "refseq_ac": [ { "id": "NP_001164055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164055", "type": "external" } ], "gene_names_uniprotkb": "Pex5; Pex5_predicted", "gene_names_refseq": "PTS1-BP; PTS1R; Pex5", "protein_names_uniprotkb": "Peroxisomal targeting signal 1 receptor; PTS1 receptor; PTS1-BP; PTS1R; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1", "protein_names_refseq": "PTS1 receptor; peroxin-5; peroxisomal C-terminal targeting signal import receptor; peroxisomal targeting signal 1 receptor-like; peroxisomal targeting signal 1 receptor; peroxisome biogenesis factor 5; peroxisome receptor 1", "tax_id": 10116, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); peroxisome biogenesis disorder 2A (Disease Ontology:DOID:0080477); peroxisome biogenesis disorder 2B (Disease Ontology:DOID:0080622); rhizomelic chondrodysplasia punctata type 5 (Disease Ontology:DOID:0110854)", "pathway": " (rno:312703); (R-RNO-8866654); (R-RNO-9033241); (R-RNO-9664873)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "18359941;22371489;34174269;38470934", "class_list": "", "function": "In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Noncanonical and reversible cysteine ubiquitination prevents the overubiquitination of PEX5 at the peroxisomal membrane. Publication Status: Online-Only, [RefSeq, PubMed]; Our results suggest that ubiquitin-specific protease 9X (USP9X) is by far the most active deubiquitinase acting on Ub-PEX5, both in female rat liver and HeLa cells., [RefSeq, PubMed]; PEX5 prevents cardiomyocyte hypertrophy via suppressing the redox-sensitive signaling pathways MAPKs and STAT3., [RefSeq, PubMed]; Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033328 peroxisome membrane targeting sequence binding;GO:0019899 enzyme binding;GO:0031267 small GTPase binding;GO:0005052 peroxisome matrix targeting signal-1 binding;GO:0000268 peroxisome targeting sequence binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0044721 protein import into peroxisome matrix, substrate release;GO:0000038 very long-chain fatty acid metabolic process;GO:0006629 lipid metabolic process;GO:0006635 fatty acid beta-oxidation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q2M2R8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53813-1", "uniprot_id": [ { "id": "PROS_RAT", "url": "https://www.uniprot.org/uniprot/P53813", "type": "external" } ], "mass": 74627.0, "length": 675, "protein_name": "Vitamin K-dependent protein S", "gene_name": "Pros1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pros1; Pros", "gene_names_refseq": "", "protein_names_uniprotkb": "Vitamin K-dependent protein S", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant thrombophilia due to protein S deficiency (Disease Ontology:DOID:0111900); autosomal recessive thrombophilia due to protein S deficiency (Disease Ontology:DOID:0111905); protein S deficiency (Disease Ontology:DOID:2451); cerebral infarction (Disease Ontology:DOID:3526)", "pathway": " (rno:81750); (R-RNO-114608); (R-RNO-159740); (R-RNO-159763); (R-RNO-159782); (R-RNO-202733); (R-RNO-9769739); (R-RNO-9769743)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "29393594;7608128", "class_list": "", "function": "Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001889 liver development;GO:0032496 response to lipopolysaccharide;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0007596 blood coagulation;GO:0042730 fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P53813-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85118-1", "uniprot_id": [ { "id": "NT8F2_RAT", "url": "https://www.uniprot.org/uniprot/P85118", "type": "external" } ], "mass": 25503.0, "length": 226, "protein_name": "N-acetyltransferase family 8 member 2", "gene_name": "Nat8f2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nat8f2; Cml2; Nat8f4", "gene_names_refseq": "", "protein_names_uniprotkb": "N-acetyltransferase family 8 member 2; 2.3.1.-; Camello-like protein 2; N-acetyltransferase-like protein CML2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:102549803); (rno:500237)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable acetyltransferase (Probable). Has no detectable histone acetyltransferase activity towards histone H3 or H4., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007369 gastrulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P85118-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RC99-1", "uniprot_id": [ { "id": "RAB5A_RAT", "url": "https://www.uniprot.org/uniprot/M0RC99", "type": "external" } ], "mass": 23625.0, "length": 215, "protein_name": "Ras-related protein Rab-5A", "gene_name": "Rab5a", "organism": "Rat", "refseq_name": "ras-related protein Rab-5A", "refseq_ac": [ { "id": "NP_073183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073183", "type": "external" } ], "gene_names_uniprotkb": "Rab5a; Rab5al1", "gene_names_refseq": "Rab5a", "protein_names_uniprotkb": "Ras-related protein Rab-5A; 3.6.5.2; Small GTP-binding protein rab5", "protein_names_refseq": "ras-related protein Rab-5A; small GTP-binding protein rab5", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:100361891); (rno:64633); (R-RNO-1660499); (R-RNO-8856828); (R-RNO-8873719); (R-RNO-8876198); (R-RNO-983231)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "27559088;30988348;36062786", "class_list": "", "function": "C-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Retrieval is also dependent on the Rab5 effector Fused Toes (FTS)-Hook-FTS and Hook-interacting protein (FHIP) (FHF) complex, which interacts with the minus-end-directed microtubule motor dynein and its activator dynactin to drive a population of axonal retrograde carriers containing somatodendritic proteins toward the soma., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes and involved in early endocytic trafficking. Required for EEA1 recruitment to early endosomes. Recruits FERRY complex to early endosomes, where FERRY links early endosomes with a subgroup of mRNAs to enable mRNA intracellular distribution (By similarity). Recruits RABEP1/Rabaptin-5 effector to early endosomes, thereby promoting endocytic membrane fusion (By similarity). Required for EGF and transferrin endocytosis and trafficking through early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (By similarity). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; [The effects of different exercise modes on Rab5 protein and glucose metabolism in skeletal muscle of type 2 diabetic mellitus rats]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88565", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0051021 GDP-dissociation inhibitor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098844 postsynaptic endocytic zone membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0031623 receptor internalization;GO:0048169 regulation of long-term neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "M0RC99-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M0RCP6-1", "uniprot_id": [ { "id": "PROF3_RAT", "url": "https://www.uniprot.org/uniprot/M0RCP6", "type": "external" } ], "mass": 14667.0, "length": 137, "protein_name": "Profilin-3", "gene_name": "Pfn3", "organism": "Rat", "refseq_name": "profilin-3", "refseq_ac": [ { "id": "NP_001102957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102957", "type": "external" } ], "gene_names_uniprotkb": "Pfn3", "gene_names_refseq": "Pfn3", "protein_names_uniprotkb": "Profilin-3; Profilin III", "protein_names_refseq": "profilin III; profilin-3", "tax_id": 10116, "disease": "", "pathway": " (rno:685936)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15591451;19419568", "class_list": "", "function": "Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0030036 actin cytoskeleton organization;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "M0RCP6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08658-1", "uniprot_id": [ { "id": "NUP88_RAT", "url": "https://www.uniprot.org/uniprot/O08658", "type": "external" } ], "mass": 83585.0, "length": 742, "protein_name": "Nuclear pore complex protein Nup88", "gene_name": "Nup88", "organism": "Rat", "refseq_name": "nuclear pore complex protein Nup88", "refseq_ac": [ { "id": "NP_446068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446068", "type": "external" } ], "gene_names_uniprotkb": "Nup88; Nup84", "gene_names_refseq": "Nup84; Nup88; Prei2", "protein_names_uniprotkb": "Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup84; Nucleoporin Nup88", "protein_names_refseq": "88 kDa nuclear pore complex protein; 88 kDa nucleoporin; nuclear pore complex protein Nup88; nucleoporin 88kDa; nucleoporin Nup84; nucleoporin Nup88; preimplantation protein 2", "tax_id": 10116, "disease": "fetal akinesia deformation sequence syndrome 4 (Disease Ontology:DOID:0111379)", "pathway": " (rno:113929); (R-RNO-159227); (R-RNO-159230); (R-RNO-159231); (R-RNO-159236); (R-RNO-170822); (R-RNO-1855170); (R-RNO-1855196); (R-RNO-1855229); (R-RNO-191859); (R-RNO-3108214); (R-RNO-3232142); (R-RNO-3301854); (R-RNO-3371453); (R-RNO-4085377); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885)", "pathway_count": 18, "publication_count": 2, "publication_id_list": "22673903;9166401", "class_list": "", "function": "Component of nuclear pore complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore", "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0006406 mRNA export from nucleus;GO:0006606 protein import into nucleus;GO:0000056 ribosomal small subunit export from nucleus;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08658-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08699-1", "uniprot_id": [ { "id": "PGDH_RAT", "url": "https://www.uniprot.org/uniprot/O08699", "type": "external" } ], "mass": 28939.0, "length": 266, "protein_name": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]", "gene_name": "Hpgd", "organism": "Rat", "refseq_name": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]", "refseq_ac": [ { "id": "NP_077366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077366", "type": "external" } ], "gene_names_uniprotkb": "Hpgd; Pgdh1", "gene_names_refseq": "Hpgd", "protein_names_uniprotkb": "15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 1.1.1.-; 1.1.1.141; 1.1.1.232; 15-PGDH; Eicosanoid/docosanoid dehydrogenase [NAD(+)]; Prostaglandin dehydrogenase 1", "protein_names_refseq": "15-PGDH; 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; NAD-dependent 15-hydroxyprostaglandin dehydrogenase; PGDH; eicosanoid/docosanoid dehydrogenase; hydroxyprostaglandin dehydrogenase 15 (NAD); prostaglandin dehydrogenase 1", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); primary hypertrophic osteoarthropathy (Disease Ontology:DOID:14283); colon carcinoma (Disease Ontology:DOID:1520); carcinoma (Disease Ontology:DOID:305); prolactinoma (Disease Ontology:DOID:5394); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750)", "pathway": " (rno:79242); (R-RNO-2142700); (R-RNO-9018676); (R-RNO-9018896)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "24647712;25779923;9099857", "class_list": "", "function": "Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (By similarity) (PubMed:9099857). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Results showed that 15-PGDH mRNA and protein expression was reduced in the hypothalamus and lungs in stressed animals compared with controls, which was correlated with a reduction of enzymatic activity, [RefSeq, PubMed]; Results support a possibility that 15-PGDH may regulate postnatal kidney development through interaction with COX-2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P687", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.141", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.141", "type": "external" }, { "id": "1.1.1.232", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.232", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0070403 NAD+ binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:2001301 lipoxin biosynthetic process;GO:0032496 response to lipopolysaccharide;GO:0043065 positive regulation of apoptotic process;GO:0045471 response to ethanol;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08699-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08835-1", "uniprot_id": [ { "id": "SYT11_RAT", "url": "https://www.uniprot.org/uniprot/O08835", "type": "external" } ], "mass": 48268.0, "length": 430, "protein_name": "Synaptotagmin-11", "gene_name": "Syt11", "organism": "Rat", "refseq_name": "synaptotagmin-11 isoform X1", "refseq_ac": [ { "id": "XP_006232810", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006232810", "type": "external" } ], "gene_names_uniprotkb": "Syt11", "gene_names_refseq": "Syt11", "protein_names_uniprotkb": "Synaptotagmin-11; Synaptotagmin XI; SytXI", "protein_names_refseq": "synaptotagmin-11 isoform X1", "tax_id": 10116, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "24882364;26589353;29311685;30021165;38843836;9162066", "class_list": "", "function": "Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+) (PubMed:9162066). Inhibits clathrin-mediated and bulk endocytosis in neurons, functions to ensure precision in vesicle retrieval (PubMed:26589353, PubMed:29311685). Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process (PubMed:29311685). Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q925B6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0000149 SNARE binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0001778 plasma membrane repair;GO:1903979 negative regulation of microglial cell activation;GO:0045806 negative regulation of endocytosis;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O08835-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35092-1", "uniprot_id": [ { "id": "TI17A_RAT", "url": "https://www.uniprot.org/uniprot/O35092", "type": "external" } ], "mass": 18038.0, "length": 171, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim17-A", "gene_name": "Timm17a", "organism": "Rat", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim17-A", "refseq_ac": [ { "id": "NP_062224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062224", "type": "external" } ], "gene_names_uniprotkb": "Timm17a; Mimt17; Tim17a; Tim17; Timm17", "gene_names_refseq": "Tim17; Timm17a; Timm17", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim17-A; Inner membrane preprotein translocase Tim17a", "protein_names_refseq": "inner membrane preprotein translocase Tim17a; mitochondrial import inner membrane translocase subunit Tim17-A; translocase of inner mitochondrial membrane 17 homolog A; translocator of inner mitochondrial membrane 17 kDa, a; translocator of inner mitochondrial membrane 17a", "tax_id": 10116, "disease": "", "pathway": " (rno:54311)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9538267", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0010954 positive regulation of protein processing;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35092-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35263-1", "uniprot_id": [ { "id": "PA1B3_RAT", "url": "https://www.uniprot.org/uniprot/O35263", "type": "external" } ], "mass": 25863.0, "length": 232, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit alpha1", "gene_name": "Pafah1b3", "organism": "Rat", "refseq_name": "platelet-activating factor acetylhydrolase IB subunit alpha1", "refseq_ac": [ { "id": "NP_446106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446106", "type": "external" } ], "gene_names_uniprotkb": "Pafah1b3; Pafahg", "gene_names_refseq": "Pafah1b3", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit alpha1; 3.1.1.47; PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH alpha 1; PAF-AH subunit gamma; PAFAH subunit gamma; Platelet-activating factor acetylhydrolase alpha 1 subunit", "protein_names_refseq": "PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH alpha 1; PAF-AH subunit gamma; PAFAH subunit gamma; platelet-activating factor acetylhydrolase IB subunit alpha1; platelet-activating factor acetylhydrolase IB subunit gamma; platelet-activating factor acetylhydrolase alpha 1 subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:114113); (R-RNO-6811436)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20074623;9459487;9660828", "class_list": "", "function": "Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF (PubMed:9660828). The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; These results suggest that PAF induces synaptic facilitation through activation of CaMKII, PKC and ERK in the hippocampal CA1 region., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" } ], "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35263-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35775-1", "uniprot_id": [ { "id": "SYCN_RAT", "url": "https://www.uniprot.org/uniprot/O35775", "type": "external" } ], "mass": 14635.0, "length": 134, "protein_name": "Syncollin", "gene_name": "Sycn", "organism": "Rat", "refseq_name": "syncollin precursor", "refseq_ac": [ { "id": "NP_001376171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376171", "type": "external" } ], "gene_names_uniprotkb": "Sycn; Sip9", "gene_names_refseq": "Sycn; Syl", "protein_names_uniprotkb": "Syncollin; Proximal small intestine-specific protein 9", "protein_names_refseq": "proximal small intestine-specific protein 9; syncollin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:245917)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10666056;10753942;11389693;11853552;12235484;15766266;15817827;16517980;9244306", "class_list": "", "function": "Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042589 zymogen granule membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0006887 exocytosis;GO:0017158 regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O35775-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35881-1", "uniprot_id": [ { "id": "P2Y14_RAT", "url": "https://www.uniprot.org/uniprot/O35881", "type": "external" } ], "mass": 34800.0, "length": 305, "protein_name": "P2Y purinoceptor 14", "gene_name": "P2ry14", "organism": "Rat", "refseq_name": "P2Y purinoceptor 14", "refseq_ac": [ { "id": "NP_598261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598261", "type": "external" } ], "gene_names_uniprotkb": "P2ry14; Gpr105", "gene_names_refseq": "Gpr105; P2ry14", "protein_names_uniprotkb": "P2Y purinoceptor 14; G protein-coupled receptor 105; P2Y14; UDP-glucose receptor; VTR 15-20", "protein_names_refseq": "G protein-coupled receptor 105; G protein-coupled receptor VTR 15-20; P2Y purinoceptor 14; P2Y14; UDP-glucose receptor; VTR 15-20; purinergic receptor P2Y, G-protein coupled, 14", "tax_id": 10116, "disease": "", "pathway": " (rno:171108); (R-RNO-417957); (R-RNO-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "18638471;19164486;19896471;22872320;26976766;31032956;9295203", "class_list": "", "function": "Geniposide exerted anti-inflammatory effects by interfering with the expression of P2Y14 receptor, which subsequently inhibits the downstream ERK1/2 signaling pathways and the release of the pro-inflammatory cytokines IL-8, MCP-1, IL-1beta., [RefSeq, PubMed]; Mast cells express an endogenous P2Y(14) receptor, which mediates G(i)-dependent degranulation and is therefore a potential novel therapeutic target for allergic conditions., [RefSeq, PubMed]; Our findings directly proved the functional presence of P2Y14 receptor in satellite glial cells. It was also verified that P2Y14 receptor activation was involved in activating satellite glial cells, [RefSeq, PubMed]; Receptor for UDP-glucose coupled to G proteins., [UniProtKB]; These results demonstrate a novel function of the P2Y14 receptor in the rodent stomach and an ability of UDP-glucose to delay gastric emptying without involving the P2Y14 receptor., [RefSeq, PubMed]; We demonstrated the presence and the activity of the P2Y14 receptor in glioma C6 cells, [RefSeq, PubMed]; When Gi-coupled signaling is removed from astrocyte P2Y14 receptors, the cells start to release TNF-alpha, boosting MMP-9 secretion., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0061484 hematopoietic stem cell homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O35881-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35956-1", "uniprot_id": [ { "id": "S22A6_RAT", "url": "https://www.uniprot.org/uniprot/O35956", "type": "external" } ], "mass": 60766.0, "length": 551, "protein_name": "Solute carrier family 22 member 6", "gene_name": "Slc22a6", "organism": "Rat", "refseq_name": "solute carrier family 22 member 6", "refseq_ac": [ { "id": "NP_058920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058920", "type": "external" } ], "gene_names_uniprotkb": "Slc22a6; Oat1", "gene_names_refseq": "Oat1; Orctl1; Paht; Roat1; Slc22a6", "protein_names_uniprotkb": "Solute carrier family 22 member 6; Organic anion transporter 1; rOAT1; rROAT1; renal organic anion transporter 1", "protein_names_refseq": "organic anion transporter 1; organic cationic transporter-like 1; rROAT1; renal organic anion transporter 1; solute carrier family 22 (organic anion transporter), member 6; solute carrier family 22 member 6", "tax_id": 10116, "disease": "", "pathway": " (rno:29509); (R-RNO-561048)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10462545;14675047;16338963;17245393;23832370;29436232;32271169;32451678;33790363;9228014;9374486", "class_list": "", "function": "Distribution of the organic anion transporters Oat1 and Oat3 between renal membrane microdomains in obstructive jaundice., [RefSeq, PubMed]; Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease. Publication Status: Online-Only, [RefSeq, PubMed]; Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2. Publication Status: Online-Only, [RefSeq, PubMed]; Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as alpha-ketoglutarate or glutarate (PubMed:14675047, PubMed:23832370, PubMed:9228014, PubMed:9374486). Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine (By similarity). Function as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4) dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (By similarity). Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion (PubMed:9228014). Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP (PubMed:9228014). Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain (PubMed:23832370). May transport glutamate (By similarity). Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body (PubMed:14675047, PubMed:9228014). Uremic toxins include the indoxyl sulfate (IS), hippurate, indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate(CMPF) and urate (PubMed:14675047, PubMed:9228014). Xenobiotics include the mycotoxin ochratoxin (OTA) (By similarity). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier (By similarity). May also work as a bidirectional OA/dicarboxylate exchanger (PubMed:9228014)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Study results indicate that Oat1 and Oat3 at the blood-arachnoid barrier provide a distinct clearance pathway of organic anion drugs from cerebrospinal fluid independently of choroid plexus., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0005452 solute:inorganic anion antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005901 caveola;GO:0009925 basal plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0072237 metanephric proximal tubule development;GO:0051260 protein homooligomerization;GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport;GO:0006820 monoatomic anion transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "O35956-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54698-1", "uniprot_id": [ { "id": "S29A1_RAT", "url": "https://www.uniprot.org/uniprot/O54698", "type": "external" } ], "mass": 50017.0, "length": 457, "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "Slc29a1", "organism": "Rat", "refseq_name": "equilibrative nucleoside transporter 1 isoform 1", "refseq_ac": [ { "id": "NP_113872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113872", "type": "external" } ], "gene_names_uniprotkb": "Slc29a1; Ent1", "gene_names_refseq": "ENT1; Slc29a1; rENT1", "protein_names_uniprotkb": "Equilibrative nucleoside transporter 1; Equilibrative NBMPR-sensitive nucleoside transporter; Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1; rENT1", "protein_names_refseq": "NBMPR-sensitive equilibrative nucleoside transporter; equilibrative NBMPR-sensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; equilibrative nucleoside transporter 1 isoform 1; equilibrative nucleoside transporter 1; nucleoside transporter, es-type; solute carrier family 29 (equilibrative nucleoside transporter), member 1; solute carrier family 29 (nucleoside transporters), member 1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); brain ischemia (Disease Ontology:DOID:2316); diffuse idiopathic skeletal hyperostosis (Disease Ontology:DOID:6652)", "pathway": " (rno:63997); (R-RNO-83936); (R-RNO-9748787); (R-RNO-9755088)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "11584005;17379602;22673903;23639800;28322028;31346513;31520644;32445645;33174009;9353301", "class_list": "", "function": "Based on these results, we suggest that XNJI promotes arousal by inhibiting adenosine neurotransmission via reducing adenosine level and the expression of A1R and ENT1. Publication Status: Online-Only, [RefSeq, PubMed]; ENT1 inhibition attenuates apoptosis by activation of cAMP/pCREB/Bcl2 pathway after MCAO in rats., [RefSeq, PubMed]; Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1., [RefSeq, PubMed]; Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake., [RefSeq, PubMed]; The purpose of this study is to determine the localization of nucleoside transporters expressed within rat epididymis to demonstrate the potential of epididymal reabsorption. Using immunohistochemistry, we determined that equilibrative nucleoside transporter 1 (ENT1) is localized to the basolateral membrane of epithelial cells, ENT2 is expressed in the nucleus of the epithelium and CNT2 is expressed by basal cells., [RefSeq, PubMed]; Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:9353301). Functions as a Na(+)-independent transporter (By similarity). Involved in the transport of nucleosides such as adenosine, thymidine and uridine (PubMed:23639800, PubMed:9353301). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (By similarity). Also mediates the uptake of nicotinamide; contributes to maintaining nicotinamide homeostasis but also regulated nicotinamide biological roles (By similarity). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (PubMed:23639800). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015212 cytidine transmembrane transporter activity;GO:0015213 uridine transmembrane transporter activity;GO:0015211 purine nucleoside transmembrane transporter activity;GO:0015207 adenine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0098794 postsynapse;GO:0098793 presynapse", "go_biological_process": "GO:0015851 nucleobase transport;GO:0015861 cytidine transport;GO:0015858 nucleoside transport;GO:0015860 purine nucleoside transmembrane transport;GO:0015862 uridine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O54698-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55145-1", "uniprot_id": [ { "id": "X3CL1_RAT", "url": "https://www.uniprot.org/uniprot/O55145", "type": "external" } ], "mass": 41977.0, "length": 393, "protein_name": "Fractalkine", "gene_name": "Cx3cl1", "organism": "Rat", "refseq_name": "fractalkine precursor", "refseq_ac": [ { "id": "NP_604450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_604450", "type": "external" } ], "gene_names_uniprotkb": "Cx3cl1; Acc1; Fkn; Scyd1", "gene_names_refseq": "Cx3cl1; Cx3c; Scyd1", "protein_names_uniprotkb": "Fractalkine; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1", "protein_names_refseq": "C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; chemokine (C-X3-C motif) ligand 1; fractalkine precursor; fractalkine; neurotactin; small inducible cytokine subfamily D, 1; small-inducible cytokine D1", "tax_id": 10116, "disease": "polymyositis (Disease Ontology:DOID:0080745); Parkinsonism (Disease Ontology:DOID:0080855); dermatomyositis (Disease Ontology:DOID:10223); common cold (Disease Ontology:DOID:10459); portal hypertension (Disease Ontology:DOID:10762); uveitis (Disease Ontology:DOID:13141); cystitis (Disease Ontology:DOID:1679); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); glomerulonephritis (Disease Ontology:DOID:2921); ischemia (Disease Ontology:DOID:326); atopic dermatitis (Disease Ontology:DOID:3310); systemic scleroderma (Disease Ontology:DOID:418); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); borna disease (Disease Ontology:DOID:5154); pulmonary hypertension (Disease Ontology:DOID:6432); prion disease (Disease Ontology:DOID:649); rheumatoid arthritis (Disease Ontology:DOID:7148); myocarditis (Disease Ontology:DOID:820); lung disease (Disease Ontology:DOID:850); Cor pulmonale (Disease Ontology:DOID:8515); chronic fatigue syndrome (Disease Ontology:DOID:8544); hepatopulmonary syndrome (Disease Ontology:DOID:900); pulmonary embolism (Disease Ontology:DOID:9477); polyarteritis nodosa (Disease Ontology:DOID:9810)", "pathway": " (rno:89808); (R-RNO-380108); (R-RNO-418594)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "33969675;34629047;35382731;37045646;38937701;9724801;9845323", "class_list": "", "function": "Bone marrow stromal cells reverse the microglia type from pro-inflammatory tumour necrosis factor a microglia to anti-inflammatory CD206 microglia of middle cerebral artery occlusion rats through triggering secretion of CX3CL1., [RefSeq, PubMed]; Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1., [UniProtKB, UniProtKB]; Dapagliflozin Protects H9c2 Cells Against Injury Induced by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and NF-kappaB Activity., [RefSeq, PubMed]; Expression and significance of Fractalkine/CX3CL1 in MPO-AAV-associated glomerulonephritis rats. Erratum:[BMC Nephrol. 2024 Aug 1;25(1):249. doi: 10.1186/s12882-024-03680-1. PMID: 39090555] Publication Status: Online-Only, [RefSeq, PubMed]; FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats. Publication Status: Online-Only, [RefSeq, PubMed]; Spinal Cord Stimulation Increases Chemoefficacy and Prevents Paclitaxel-Induced Pain via CX3CL1., [RefSeq, PubMed]; The membrane-bound form promotes adhesion of those leukocytes to endothelial cells., [UniProtKB, UniProtKB]; The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 29, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031737 CX3C chemokine receptor binding;GO:0005178 integrin binding;GO:0042056 chemoattractant activity;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:1904141 positive regulation of microglial cell migration;GO:1903979 negative regulation of microglial cell activation;GO:0032233 positive regulation of actin filament bundle assembly;GO:0032914 positive regulation of transforming growth factor beta1 production;GO:0051041 positive regulation of calcium-independent cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O55145-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55166-1", "uniprot_id": [ { "id": "VPS52_RAT", "url": "https://www.uniprot.org/uniprot/O55166", "type": "external" } ], "mass": 82103.0, "length": 723, "protein_name": "Vacuolar protein sorting-associated protein 52 homolog", "gene_name": "Vps52", "organism": "Rat", "refseq_name": "vacuolar protein sorting-associated protein 52 homolog", "refseq_ac": [ { "id": "NP_149088", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_149088", "type": "external" } ], "gene_names_uniprotkb": "Vps52; Are1; Sacm2l", "gene_names_refseq": "Are1; Sacm2l; Vps52", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 52 homolog; SAC2 suppressor of actin mutations 2-like protein", "protein_names_refseq": "SAC2 suppressor of actin mutations 2-like protein; VPS52 GARP complex subunit; vacuolar protein sorting 52 homolog; vacuolar protein sorting-associated protein 52 homolog", "tax_id": 10116, "disease": "lymphoid leukemia (Disease Ontology:DOID:1037); malaria (Disease Ontology:DOID:12365); glomerulonephritis (Disease Ontology:DOID:2921); end stage renal disease (Disease Ontology:DOID:783); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:25218); (R-RNO-6811440)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15060004;27440922;9790748", "class_list": "", "function": "Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000938 GARP complex;GO:1990745 EARP complex;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006605 protein targeting;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling;GO:0007041 lysosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O55166-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70247-1", "uniprot_id": [ { "id": "SC5A6_RAT", "url": "https://www.uniprot.org/uniprot/O70247", "type": "external" } ], "mass": 68642.0, "length": 634, "protein_name": "Sodium-dependent multivitamin transporter", "gene_name": "Slc5a6", "organism": "Rat", "refseq_name": "sodium-dependent multivitamin transporter", "refseq_ac": [ { "id": "NP_570102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570102", "type": "external" } ], "gene_names_uniprotkb": "Slc5a6; Smvt", "gene_names_refseq": "SMVT; Slc5a6", "protein_names_uniprotkb": "Sodium-dependent multivitamin transporter; Na(+)-dependent multivitamin transporter; Solute carrier family 5 member 6", "protein_names_refseq": "Na(+)-dependent multivitamin transporter; sodium-dependent multivitamin transporter; solute carrier family 5 (sodium-dependent vitamin transporter), member 6; solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6", "tax_id": 10116, "disease": "vitamin metabolic disorder (Disease Ontology:DOID:0050718)", "pathway": " (rno:170551); (R-RNO-196780); (R-RNO-199220); (R-RNO-425397)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "12620923;9516450", "class_list": "", "function": "Expression of SMVT is developmentally regulated in jejunal epithelial brush border membranes, [RefSeq, PubMed]; Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:9516450). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane (By similarity). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008523 sodium-dependent multivitamin transmembrane transporter activity;GO:0090482 vitamin transmembrane transporter activity;GO:0015111 iodide transmembrane transporter activity;GO:0015225 biotin transmembrane transporter activity;GO:0015233 pantothenate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015878 biotin transport;GO:0015887 pantothenate transmembrane transport;GO:0006768 biotin metabolic process;GO:0006814 sodium ion transport;GO:0150104 transport across blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70247-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70301-1", "uniprot_id": [ { "id": "PSPN_RAT", "url": "https://www.uniprot.org/uniprot/O70301", "type": "external" } ], "mass": 17063.0, "length": 156, "protein_name": "Persephin", "gene_name": "Pspn", "organism": "Rat", "refseq_name": "persephin precursor", "refseq_ac": [ { "id": "NP_037146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037146", "type": "external" } ], "gene_names_uniprotkb": "Pspn", "gene_names_refseq": "PSP; Pspn", "protein_names_uniprotkb": "Persephin; PSP", "protein_names_refseq": "persephin precursor", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); amyotrophic lateral sclerosis type 19 (Disease Ontology:DOID:0060210); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); urinary bladder cancer (Disease Ontology:DOID:11054); interstitial cystitis (Disease Ontology:DOID:13949); alcohol use disorder (Disease Ontology:DOID:1574); cancer (Disease Ontology:DOID:162); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carcinoma (Disease Ontology:DOID:305); bipolar disorder (Disease Ontology:DOID:3312); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); radiculopathy (Disease Ontology:DOID:4306); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419); stomach carcinoma (Disease Ontology:DOID:5517); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); median neuropathy (Disease Ontology:DOID:571); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:25525); (R-RNO-5673001); (R-RNO-8853659)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10719212;12401443;16325003;20350599;9491986;9710270", "class_list": "", "function": "Growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons (By similarity). Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor (By similarity)., [UniProtKB, UniProtKB]; PSP promotes the survival and neurite outgrowth of midbrain dopamine neurons in vitro as potently and efficiently as GDNF., [RefSeq, PubMed]; PSPN acts potent neurotrophic factor that may play an important role in the structural development and plasticity of ventral mesencephalic dopaminergic neurons, [RefSeq, PubMed]; Results identify persephin, a GDNF family member, as a novel ligand for GFRalpha1/RET receptor complex., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 32, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding;GO:0008083 growth factor activity;GO:0030116 glial cell-derived neurotrophic factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway;GO:0031175 neuron projection development;GO:0001658 branching involved in ureteric bud morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O70301-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70531-1", "uniprot_id": [ { "id": "S26A2_RAT", "url": "https://www.uniprot.org/uniprot/O70531", "type": "external" } ], "mass": 82028.0, "length": 739, "protein_name": "Sulfate transporter", "gene_name": "Slc26a2", "organism": "Rat", "refseq_name": "sulfate transporter", "refseq_ac": [ { "id": "NP_476468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476468", "type": "external" } ], "gene_names_uniprotkb": "Slc26a2; Dtdst", "gene_names_refseq": "Dtdst; Slc26a2", "protein_names_uniprotkb": "Sulfate transporter; Diastrophic dysplasia protein homolog; Solute carrier family 26 member 2", "protein_names_refseq": "diastrophic dysplasia protein homolog; solute carrier family 26 (anion exchanger), member 2; solute carrier family 26 (sulfate transporter), member 2; sulfate transporter", "tax_id": 10116, "disease": "brachydactyly (Disease Ontology:DOID:0050581); atelosteogenesis (Disease Ontology:DOID:0050648); multiple epiphyseal dysplasia 4 (Disease Ontology:DOID:0070300); achondrogenesis type IB (Disease Ontology:DOID:0080055); diastrophic dysplasia (Disease Ontology:DOID:14687); osteochondrodysplasia (Disease Ontology:DOID:2256); spondylolysis (Disease Ontology:DOID:2300); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676)", "pathway": " (rno:117267); (R-RNO-174362); (R-RNO-427601)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "20369363;9575183", "class_list": "", "function": "DTDST protein expression was limited to the microvillus membrane of proximal tubule cells in the renal cortex but absent in glomeruli and other nephron segments. DTDST may play a role in proximal tubule sulfate transport., [RefSeq, PubMed]; Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:9575183). Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005452 solute:inorganic anion antiporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031528 microvillus membrane", "go_biological_process": "GO:0019532 oxalate transport;GO:1902476 chloride transmembrane transport;GO:0002062 chondrocyte differentiation;GO:0035988 chondrocyte proliferation;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O70531-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88436-1", "uniprot_id": [ { "id": "PAX4_RAT", "url": "https://www.uniprot.org/uniprot/O88436", "type": "external" } ], "mass": 38485.0, "length": 349, "protein_name": "Paired box protein Pax-4", "gene_name": "Pax4", "organism": "Rat", "refseq_name": "paired box protein Pax-4", "refseq_ac": [ { "id": "NP_113987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113987", "type": "external" } ], "gene_names_uniprotkb": "Pax4", "gene_names_refseq": "Pax4", "protein_names_uniprotkb": "Paired box protein Pax-4", "protein_names_refseq": "paired box gene 4; paired box protein Pax-4", "tax_id": 10116, "disease": "maturity-onset diabetes of the young type 9 (Disease Ontology:DOID:0111107); diabetic ketoacidosis (Disease Ontology:DOID:1837); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:83630)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10601637;17260022;18818287;19012751;21734788;9675102", "class_list": "", "function": "Causal association between Pax4 mRNA levels and susceptibility of rat insulinoma cells to apoptosis suggests an important physiological function for Pax4 in cell survival., [RefSeq, PubMed]; DNA-binding transcription factor that plays a central role in the differentiation and development of type B pancreatic cells, which are located within the pancreatic islets of Langerhans responsible for the production and release of insulin (By similarity). Mainly acts as a transcription repressor that binds to a common element in the glucagon, insulin and somatostatin promoters and inhibits their expression (By similarity). Prevents differentiation of type A pancreatic cells, probably by repressing expression of ARX (By similarity). Competes with another transcription factor, PAX6, for this same promoter binding site (By similarity). Also plays a key role in intestinal enteroendocrine cell differentiation by (1) directly promoting differentiation of enterochromaffin cells and (2) preventing differentiation of other intestinal enteroendocrine cell types (By similarity). Prevents differentiation of other intestinal enteroendocrine cell types by repressing the expression of ARX, the master transcription factor for intestinal type-L, -N, -D, -I and -G enteroendocrine cell differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data show that Ngn3 and Pax4, a transcription factor that lies downstream of Ngn3 and plays an important role in beta-cell differentiation, were expressed in the alpha-cells of STZ-treated rats., [RefSeq, PubMed]; Retinal expression of Pax4 is undetectable prior to birth but increases thereafter; in the adult there are daily changes which may influence retinal gene expression, [RefSeq, PubMed]; The daily changes in Pax4 expression may influence gene expression in the pineal gland. GeneRIF: Pineal expression of Pax4 is undetectable prior to birth and increases thereafter; in the adult there is a daily rhythm in Pax4 expression with high levels during the day. GeneRIF: The daily rhythm in pineal Pax4 expression is controlled by a neural system which acts on pinealocytes through an adrenergic-cyclic AMP signalling mechanism., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O88437;O88438;O88439", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003690 double-stranded DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030900 forebrain development;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88436-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88446-1", "uniprot_id": [ { "id": "S22A3_RAT", "url": "https://www.uniprot.org/uniprot/O88446", "type": "external" } ], "mass": 61050.0, "length": 551, "protein_name": "Solute carrier family 22 member 3", "gene_name": "Slc22a3", "organism": "Rat", "refseq_name": "solute carrier family 22 member 3", "refseq_ac": [ { "id": "NP_062103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062103", "type": "external" } ], "gene_names_uniprotkb": "Slc22a3; Oct3", "gene_names_refseq": "EMT; OCT3; Slc22a3", "protein_names_uniprotkb": "Solute carrier family 22 member 3; EMT; Extraneuronal monoamine transporter; Organic cation transporter 3", "protein_names_refseq": "organic cation transporter 3; solute carrier family 22 (extraneuronal monoamine transporter), member 3; solute carrier family 22 (organic cation transporter), member 3; solute carrier family 22 member 3", "tax_id": 10116, "disease": "Muir-Torre syndrome (Disease Ontology:DOID:0050465); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); squamous cell carcinoma (Disease Ontology:DOID:1749); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); lung non-small cell carcinoma (Disease Ontology:DOID:3908); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:29504); (R-RNO-2161517); (R-RNO-549127)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "12538837;15817714;16581093;17616214;18513366;19416912;23458604;27659446;9632645;9830022", "class_list": "", "function": "Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:12538837, PubMed:16581093, PubMed:23458604, PubMed:9830022). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:9632645, PubMed:9830022). Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter (PubMed:9830022). Implicated in neuronal monoamine neurotransmitters cellular uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:16581093, PubMed:19416912, PubMed:9830022). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (By similarity). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (By similarity). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (PubMed:17616214). Mediates the transport of polyamine spermidine and putrescine (PubMed:12538837, PubMed:23458604). Mediates the bidirectional transport of polyamine agmatine (PubMed:12538837). Also transports guanidine (PubMed:9632645). Mediates the transport of choline (By similarity). May mediate intracellular transport of organic cations due to its localization on endomembranes, thereby contributing to amine metabolism and intracellular signaling (PubMed:27659446)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Study is the first to examine the subcellular localization of organic cation transporter 3 (OCT3) in any tissue, and the first to explore its spatial relationship to synaptic structures in the brain. Study suggests that OCT3 not only contributes to the clearance of extracellular monoamines, but also plays a role in their intracellular disposition and action., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0019534 toxin transmembrane transporter activity;GO:0008504 monoamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0031966 mitochondrial membrane;GO:0043025 neuronal cell body;GO:0012505 endomembrane system", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0015844 monoamine transport;GO:0015695 organic cation transport;GO:0032098 regulation of appetite;GO:0015711 organic anion transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "O88446-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88484-1", "uniprot_id": [ { "id": "PDP2_RAT", "url": "https://www.uniprot.org/uniprot/O88484", "type": "external" } ], "mass": 59687.0, "length": 530, "protein_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial", "gene_name": "Pdp2", "organism": "Rat", "refseq_name": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_659559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659559", "type": "external" } ], "gene_names_uniprotkb": "Pdp2", "gene_names_refseq": "Pdp2", "protein_names_uniprotkb": "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; 3.1.3.43; PDP 2; PDPC 2; Pyruvate dehydrogenase phosphatase catalytic subunit 2", "protein_names_refseq": "PDP 2; PDPC 2; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; pyruvate dehydrogenase phosphatase isoenzyme 2; pyruvate dehyrogenase phosphatase catalytic subunit 2", "tax_id": 10116, "disease": "", "pathway": " (rno:246311); (R-RNO-204174)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12765946;14644048;9651365", "class_list": "", "function": "Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA (PubMed:14644048, PubMed:9651365). Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17 (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Starvation and diabetes reduce the amount of this enzyme in heart and kidney., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JSL7;Q6IN27", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" } ], "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0042594 response to starvation;GO:0042093 T-helper cell differentiation;GO:0035970 peptidyl-threonine dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O88484-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O89044-1", "uniprot_id": [ { "id": "PRI2_RAT", "url": "https://www.uniprot.org/uniprot/O89044", "type": "external" } ], "mass": 58603.0, "length": 507, "protein_name": "DNA primase large subunit", "gene_name": "Prim2", "organism": "Rat", "refseq_name": "DNA primase large subunit isoform 1", "refseq_ac": [ { "id": "NP_001386112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386112", "type": "external" } ], "gene_names_uniprotkb": "Prim2", "gene_names_refseq": "Pola3; Prim2", "protein_names_uniprotkb": "DNA primase large subunit; DNA primase 58 kDa subunit; p58", "protein_names_refseq": "DNA polymerase alpha subunit III (primase); DNA primase 58 kDa subunit; DNA primase large subunit isoform 1; DNA primase large subunit; DNA primase, p58 subunit; p58; primase (DNA) subunit 2; primase, DNA, polypeptide 2", "tax_id": 10116, "disease": "", "pathway": " (rno:301323); (R-RNO-113501); (R-RNO-174411); (R-RNO-174430); (R-RNO-68952); (R-RNO-68962); (R-RNO-69091); (R-RNO-69166); (R-RNO-69183)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit (By similarity). Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0003899 DNA-directed RNA polymerase activity;GO:0071667 DNA/RNA hybrid binding", "go_cellular_component": "GO:0005658 alpha DNA polymerase:primase complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006260 DNA replication;GO:0006270 DNA replication initiation;GO:0006269 DNA replication, synthesis of primer", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O89044-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01237-1", "uniprot_id": [ { "id": "PRL_RAT", "url": "https://www.uniprot.org/uniprot/P01237", "type": "external" } ], "mass": 25753.0, "length": 226, "protein_name": "Prolactin", "gene_name": "Prl", "organism": "Rat", "refseq_name": "prolactin isoform 1 precursor", "refseq_ac": [ { "id": "NP_036761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036761", "type": "external" } ], "gene_names_uniprotkb": "Prl", "gene_names_refseq": "Gha1; PRLB; PRLSD1; Prl1a1; Prl; Prol; RATPRLSD1; RNPROL", "protein_names_uniprotkb": "Prolactin; PRL", "protein_names_refseq": "growth hormone a1; prolactin family 1, subfamily a, member 1; prolactin isoform 1 precursor", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); portal hypertension (Disease Ontology:DOID:10762); impulse control disorder (Disease Ontology:DOID:10937); hyperprolactinemia (Disease Ontology:DOID:12700); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); severe acute respiratory syndrome (Disease Ontology:DOID:2945); carotid artery disease (Disease Ontology:DOID:3407); prolactinoma (Disease Ontology:DOID:5394); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:24683); (R-RNO-1170546); (R-RNO-982772)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "36752584;37232379;37797313;38465779;38945469;6251061;6283362;6993473;728396;925136", "class_list": "", "function": "Mast Cell Dynamics in the Ovary Are Governed by GnRH and Prolactin., [RefSeq, PubMed]; Neuregulin 4 (Nrg4) cooperates with melatonin to regulate the PRL expression via ErbB4/Erk signaling pathway as a potential prolactin (PRL) regulator., [RefSeq, PubMed]; Neuroprotection mediated by prolactin against streptozotocin injury in brain rat areas., [RefSeq, PubMed]; Prolactin Regulates Testicular Gene Expression and Cell Cycle Processes Predominantly via JAK2/STAT5 Pathway in the Male Rat., [RefSeq, PubMed]; Prolactin acts primarily on the mammary gland by promoting lactation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Prolactin in headache and migraine: A systematic review of preclinical studies., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70520", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0097305 response to alcohol;GO:0010730 negative regulation of hydrogen peroxide biosynthetic process;GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0007166 cell surface receptor signaling pathway;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P01237-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02782-1", "uniprot_id": [ { "id": "PSC1_RAT", "url": "https://www.uniprot.org/uniprot/P02782", "type": "external" } ], "mass": 12763.0, "length": 111, "protein_name": "Prostatic steroid-binding protein C1", "gene_name": "Psbpc1", "organism": "Rat", "refseq_name": "prostatic steroid-binding protein C1 precursor", "refseq_ac": [ { "id": "NP_803435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803435", "type": "external" } ], "gene_names_uniprotkb": "Psbpc1; Scgb1d2", "gene_names_refseq": "Pbpc1bs; Psbpc1; Scgb1d2", "protein_names_uniprotkb": "Prostatic steroid-binding protein C1; Prostatein peptide C1", "protein_names_refseq": "androgen receptor; prostatein peptide C1; prostatic steroid-binding protein C1 precursor; prostatic steroid-binding protein C1", "tax_id": 10116, "disease": "", "pathway": " (rno:309203)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "6688048;6896362;7198120;7200013", "class_list": "", "function": "Part of prostatein which is the major secretory glycoprotein of ventral prostate gland., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P60808;Q499X0;Q63469", "ec_number_list": [], "go_molecular_function": "GO:0005496 steroid binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02782-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03926-1", "uniprot_id": [ { "id": "NU6M_RAT", "url": "https://www.uniprot.org/uniprot/P03926", "type": "external" } ], "mass": 18923.0, "length": 172, "protein_name": "NADH-ubiquinone oxidoreductase chain 6", "gene_name": "Mt-nd6", "organism": "Rat", "refseq_name": "NADH dehydrogenase subunit 6", "refseq_ac": [ { "id": "YP_665640", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_665640", "type": "external" } ], "gene_names_uniprotkb": "Mt-nd6; Mtnd6; Nd6", "gene_names_refseq": "ND6", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 6; 7.1.1.2; NADH dehydrogenase subunit 6", "protein_names_refseq": "NADH dehydrogenase subunit 6", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); spinal muscular atrophy with lower extremity predominant 2B (Disease Ontology:DOID:0070350); lactic acidosis (Disease Ontology:DOID:3650); Leigh disease (Disease Ontology:DOID:3652); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (rno:26203); (R-RNO-5419276); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "1383760;2504926;6299885", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ZZM7", "ec_number_list": [ { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0035094 response to nicotine;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0042542 response to hydrogen peroxide;GO:0042220 response to cocaine;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P03926-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04089-1", "uniprot_id": [ { "id": "PTHY_RAT", "url": "https://www.uniprot.org/uniprot/P04089", "type": "external" } ], "mass": 12722.0, "length": 115, "protein_name": "Parathyroid hormone", "gene_name": "Pth", "organism": "Rat", "refseq_name": "parathyroid hormone precursor", "refseq_ac": [ { "id": "NP_058740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058740", "type": "external" } ], "gene_names_uniprotkb": "Pth", "gene_names_refseq": "PTH-(1-84); Pth1; Pthr1; Pth", "protein_names_uniprotkb": "Parathyroid hormone; PTH; Parathyrin", "protein_names_refseq": "hypothalamic parathyroid hormone; parathyrin; parathyroid hormone precursor", "tax_id": 10116, "disease": "hyperphosphatemia (Disease Ontology:DOID:0050459); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); familial isolated hypoparathyroidism 1 (Disease Ontology:DOID:0061150); calcium oxalate nephrolithiasis (Disease Ontology:DOID:0080652); autosomal dominant hypocalcemia (Disease Ontology:DOID:0090109); familial isolated hypoparathyroidism (Disease Ontology:DOID:0111387); otitis media (Disease Ontology:DOID:10754); hypertension (Disease Ontology:DOID:10763); primary hyperparathyroidism (Disease Ontology:DOID:11202); osteoporosis (Disease Ontology:DOID:11476); secondary hyperparathyroidism (Disease Ontology:DOID:12466); hypercalcemia (Disease Ontology:DOID:12678); nephrocalcinosis (Disease Ontology:DOID:12679); renal osteodystrophy (Disease Ontology:DOID:13068); osteosarcoma (Disease Ontology:DOID:3347); coronary artery disease (Disease Ontology:DOID:3393); uremia (Disease Ontology:DOID:4676); congestive heart failure (Disease Ontology:DOID:6000); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); atrophic gastritis (Disease Ontology:DOID:8929); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:24694); (R-RNO-373080)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "26669699;27989797;29529595;29633272;33945189;3628009;6321505;7588314", "class_list": "", "function": "A decrease in the RANKL/OPG ratio, associated with PTH-dependent activation of the anabolic PTH1R/ATF4 pathway, seems to be responsible for the unexpected, beneficial effect of PTH on cortical bone accrual and strength., [RefSeq, PubMed]; FGF-23 could inhibit signaling transduction of ERK/MAPK pathway and accelerate the secretion of PTH in rats with secondary hyperparathyroidism., [RefSeq, PubMed]; PTH-induced EndMT via miR-29a-5p/GSAP/Notch1 pathway contributed to valvular calcification in rats with CKD., [RefSeq, PubMed]; PTHrP and PTH mediate wasting through a common mechanism involving PTHR., [RefSeq, PubMed]; Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells., [UniProtKB, UniProtKB]; VS-105 exerts a rapid effect on suppressing serum PTH, directly down-regulates the PTH gene, and modulates PTH, VDR and CaSR gene expression more effectively than paricalcitol, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 24, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63473", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding;GO:0048018 receptor ligand activity;GO:0031857 type 1 parathyroid hormone receptor binding;GO:0031856 parathyroid hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1900158 negative regulation of bone mineralization involved in bone maturation;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007267 cell-cell signaling;GO:0010288 response to lead ion;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P04089-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05506-1", "uniprot_id": [ { "id": "NU3M_RAT", "url": "https://www.uniprot.org/uniprot/P05506", "type": "external" } ], "mass": 13087.0, "length": 115, "protein_name": "NADH-ubiquinone oxidoreductase chain 3", "gene_name": "Mt-nd3", "organism": "Rat", "refseq_name": "NADH dehydrogenase subunit 3", "refseq_ac": [ { "id": "YP_665636", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_665636", "type": "external" } ], "gene_names_uniprotkb": "Mt-nd3; Nd3", "gene_names_refseq": "ND3", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 3; 7.1.1.2; NADH dehydrogenase subunit 3", "protein_names_refseq": "NADH dehydrogenase subunit 3", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); Leigh disease (Disease Ontology:DOID:3652); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (rno:26199); (R-RNO-5419276); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "24185961;2504926", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0009725 response to hormone;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0071385 cellular response to glucocorticoid stimulus;GO:0009642 response to light intensity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P05506-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05508-1", "uniprot_id": [ { "id": "NU4M_RAT", "url": "https://www.uniprot.org/uniprot/P05508", "type": "external" } ], "mass": 51783.0, "length": 459, "protein_name": "NADH-ubiquinone oxidoreductase chain 4", "gene_name": "Mt-nd4", "organism": "Rat", "refseq_name": "NADH dehydrogenase subunit 4", "refseq_ac": [ { "id": "YP_665638", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_665638", "type": "external" } ], "gene_names_uniprotkb": "Mt-nd4; Mtnd4; Nd4", "gene_names_refseq": "ND4", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 4; 7.1.1.2; NADH dehydrogenase subunit 4", "protein_names_refseq": "NADH dehydrogenase subunit 4", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Parkinson's disease (Disease Ontology:DOID:14330); macular degeneration (Disease Ontology:DOID:4448); schizophrenia (Disease Ontology:DOID:5419); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (rno:26201); (R-RNO-5419276); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "2504926;26446791;28100784;6266779;6941716", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9T528", "ec_number_list": [ { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0035094 response to nicotine;GO:0045471 response to ethanol;GO:0001666 response to hypoxia;GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P05508-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05545-1", "uniprot_id": [ { "id": "SPA3K_RAT", "url": "https://www.uniprot.org/uniprot/P05545", "type": "external" } ], "mass": 46562.0, "length": 416, "protein_name": "Serine protease inhibitor A3K", "gene_name": "Serpina3k", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Serpina3k; Spin2b", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine protease inhibitor A3K; CPI-21; Contrapsin-like protease inhibitor 1; GHR-P63; Growth hormone-regulated proteinase inhibitor; KBP; Kallikrein-binding protein; SPI-2.3; SPI-2; Serine protease inhibitor 2; Serpin A3K; Thyroid hormone-regulated protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:24794)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15638460;1694763;1864837;1874745;2258058;2398056;2440672;3494016", "class_list": "", "function": "Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "P14281;Q64254;Q6P6G8", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0001937 negative regulation of endothelial cell proliferation;GO:0034097 response to cytokine;GO:0016525 negative regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P05545-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05942-1", "uniprot_id": [ { "id": "S10A4_RAT", "url": "https://www.uniprot.org/uniprot/P05942", "type": "external" } ], "mass": 11776.0, "length": 101, "protein_name": "Protein S100-A4", "gene_name": "S100a4", "organism": "Rat", "refseq_name": "protein S100-A4", "refseq_ac": [ { "id": "NP_036750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036750", "type": "external" } ], "gene_names_uniprotkb": "S100a4", "gene_names_refseq": "18A2; 42A; CAPL; MTS1; P9ka; PEL98; RNP9KA; S100a4", "protein_names_uniprotkb": "Protein S100-A4; Metastasin; Nerve growth factor-induced protein 42A; P9K; Placental calcium-binding protein; S100 calcium-binding protein A4", "protein_names_refseq": "P9K; Protein 9 Ka homologous to calcium-binding protein; calvasculin; metastasin; nerve growth factor-induced protein 42A; placental calcium-binding protein; protein S100-A4", "tax_id": 10116, "disease": "", "pathway": " (rno:24615)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1741158;28235243;30083275;3422491;3430604;37683711;38360265", "class_list": "", "function": "Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (By similarity). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data indicate that microRNA miR-124 targets S100 calcium-binding protein A4 (S100A4) 3' UTR and regulates vascular smooth muscle cell proliferation., [RefSeq, PubMed]; S100A4 modulates cell proliferation, apoptosis and fibrosis in the hyperplastic prostate., [RefSeq, PubMed]; These data suggest that the S100-ErbB axis may be an important mechanism regulating neuronal survival and plasticity. Publication Status: Online-Only, [RefSeq, PubMed]; Upregulation of hypothalamic TRPV4 via S100a4/AMPKalpha signaling pathway promotes the development of diet-induced obesity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0003779 actin binding;GO:0042056 chemoattractant activity;GO:0042802 identical protein binding;GO:0046914 transition metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P05942-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05964-1", "uniprot_id": [ { "id": "S10A6_RAT", "url": "https://www.uniprot.org/uniprot/P05964", "type": "external" } ], "mass": 10035.0, "length": 89, "protein_name": "Protein S100-A6", "gene_name": "S100a6", "organism": "Rat", "refseq_name": "protein S100-A6", "refseq_ac": [ { "id": "NP_445937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445937", "type": "external" } ], "gene_names_uniprotkb": "S100a6; Cacy", "gene_names_refseq": "S100a6", "protein_names_uniprotkb": "Protein S100-A6; Calcyclin; Prolactin receptor-associated protein; S100 calcium-binding protein A6", "protein_names_refseq": "calcium binding protein A6 (calcyclin); calcyclin; prolactin receptor-associated protein; protein S100-A6", "tax_id": 10116, "disease": "", "pathway": " (rno:85247)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10673048;2448309;28174168;31916625;33942537", "class_list": "", "function": "Calcyclin (S100A6) Attenuates Inflammatory Response and Mediates Apoptosis of Chondrocytes in Osteoarthritis via the PI3K/AKT Pathway., [RefSeq, PubMed]; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity)., [UniProtKB]; S100A6 is a positive regulator of PPP5C-FKBP51-dependent regulation of endothelial calcium signaling., [RefSeq, PubMed]; S100A6 overexpression by ultrasound-targeted microbubble destruction helps ameliorate myocardial ischemia-reperfusion, resulting in lower mortality and improved left ventricular systolic function post-ischemia-reperfusion via attenuation of apoptosis, reduction in cardiac hypertrophy, and reduced infarct size Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R2B7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0098586 cellular response to virus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P05964-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06767-1", "uniprot_id": [ { "id": "TKN1_RAT", "url": "https://www.uniprot.org/uniprot/P06767", "type": "external" } ], "mass": 15001.0, "length": 130, "protein_name": "Protachykinin-1", "gene_name": "Tac1", "organism": "Rat", "refseq_name": "protachykinin-1 isoform b precursor", "refseq_ac": [ { "id": "NP_001118240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001118240", "type": "external" } ], "gene_names_uniprotkb": "Tac1; Nka; Nkna; Tac2", "gene_names_refseq": "PPTA3; Ppt5fl; RATPPTA3; TAC; Tac1", "protein_names_uniprotkb": "Protachykinin-1; Neuromedin L; PPT; Substance K", "protein_names_refseq": "PPT; Tachykinin (substance P, neurokinin A, neuropeptide K, neuropeptide gamma); protachykinin-1 isoform b precursor; protachykinin-1; tachykinin 1", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432); central sleep apnea (Disease Ontology:DOID:9220)", "pathway": " (rno:24806); (R-RNO-380095); (R-RNO-416476)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "1370820;15240697;1695945;1702066;2429656;2433692;2809597;30518958;31922222;33212101;35008014;7519424;8448217", "class_list": "", "function": "Is a ligand for TACR1, and triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C (PubMed:1370820). Substance P binding to TACR1 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (PubMed:1370820). Is also a TACR3 agonist with low receptor affinity (By similarity). Basic secretagogue neuropeptide released from the terminals of specific sensory nerves (By similarity). Acts as a ligand for MRGPRB2 receptor in mast cells, initiating a signaling that mediates neurogenic inflammation and pain (By similarity). Neurogenic inflammation includes mast cell activation, recruitment of immune cells and release of inflammatory mediators, such as cytokines and chemokines (By similarity). The inflammatory response can then activate or sensitize nociceptors, promoting pain (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Is a ligand for TACR2, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:1370820). Binding to TACR2 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (PubMed:1370820)., [UniProtKB, PubMed]; Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours., [RefSeq, PubMed]; Overexpression of TIMP3 inhibits discogenic pain by suppressing angiogenesis and the expression of substance P in nucleus pulposus., [RefSeq, PubMed]; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles., [UniProtKB]; The tachykinin substance P increases neuronal excitability, participates in homeostatic control, but induces brain oedema after stroke or trauma. Blocking the NK-1 receptor prevents the occurrence of cortical spreading depression waves induced by substance P dissolved in aqua and prevents the ignition of cortical spreading depression waves by aqua alone. Publication Status: Online-Only, [RefSeq, PubMed]; UVB irradiation induces contralateral changes in galanin, substance P and c-fos immunoreactivity in rat dorsal root ganglia, dorsal horn and lateral spinal nucleus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08856;P08857;P22356;Q6LD93", "ec_number_list": [], "go_molecular_function": "GO:0031835 substance P receptor binding;GO:0031837 substance K receptor binding;GO:0005184 neuropeptide hormone activity;GO:0048018 receptor ligand activity;GO:0031836 neuromedin K receptor binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P06767-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06768-1", "uniprot_id": [ { "id": "RET2_RAT", "url": "https://www.uniprot.org/uniprot/P06768", "type": "external" } ], "mass": 15585.0, "length": 134, "protein_name": "Retinol-binding protein 2", "gene_name": "Rbp2", "organism": "Rat", "refseq_name": "retinol-binding protein 2", "refseq_ac": [ { "id": "NP_036772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036772", "type": "external" } ], "gene_names_uniprotkb": "Rbp2; Crbpii", "gene_names_refseq": "Rbp2", "protein_names_uniprotkb": "Retinol-binding protein 2; CRBP-II; Cellular retinol-binding protein II", "protein_names_refseq": "CRBP-II; Retinol-binding protein 2, cellular; cellular retinol-binding protein II; retinol binding protein 2, cellular; retinol-binding protein 2", "tax_id": 10116, "disease": "acquired angioedema (Disease Ontology:DOID:0080941); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); hypothyroidism (Disease Ontology:DOID:1459); hereditary angioedema (Disease Ontology:DOID:14735); thrombocytopenia (Disease Ontology:DOID:1588); breast cancer (Disease Ontology:DOID:1612); factor VII deficiency (Disease Ontology:DOID:2215); prothrombin deficiency (Disease Ontology:DOID:2235); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); bilirubin metabolic disorder (Disease Ontology:DOID:2741); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); hyperglycemia (Disease Ontology:DOID:4195); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24710); (R-RNO-975634)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10047490;19965581;25585692;2645288;27142737;3029082;3461459;8487303", "class_list": "", "function": "Data suggest that, as compared to controls, CrbpII expression in liver is up-regulated by pregnancy and further increased by iron deficiency; maternal iron deficiency has little impact on vitamin A levels and gene expression in placenta, but increases retinol storage in fetal liver; regulation of CrbpII expression in liver may play important roles in vitamin A metabolism in pregnant females and in fetal development., [RefSeq, PubMed]; Intracellular transport of retinol., [UniProtKB]; Protein-ligand interaction differences between CRBP-I and CRBP-II, [RefSeq, PubMed]; These results suggest that the elevated mRNA expression levels of Rbp2 and Apoa4 in the rats with SB contribute to the effective esterification and transport of vitamin A., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0044325 transmembrane transporter binding;GO:0019841 retinol binding;GO:0008289 lipid binding;GO:0016918 retinal binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0098681 synaptic ribbon", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042572 retinol metabolic process;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P06768-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09005-1", "uniprot_id": [ { "id": "SPI21_RAT", "url": "https://www.uniprot.org/uniprot/P09005", "type": "external" } ], "mass": 24218.0, "length": 214, "protein_name": "Serine protease inhibitor 2.1", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine protease inhibitor 2.1; SPI-2.1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3493437", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034097 response to cytokine", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P09005-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09321-1", "uniprot_id": [ { "id": "PR3B1_RAT", "url": "https://www.uniprot.org/uniprot/P09321", "type": "external" } ], "mass": 25007.0, "length": 221, "protein_name": "Prolactin-3B1", "gene_name": "Prl3b1", "organism": "Rat", "refseq_name": "prolactin-3B1 precursor", "refseq_ac": [ { "id": "NP_036667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036667", "type": "external" } ], "gene_names_uniprotkb": "Prl3b1; Csh2; Pl2", "gene_names_refseq": "Csh2; Ghd15; PL-II; Pl2; Prl3b1; RPLII", "protein_names_uniprotkb": "Prolactin-3B1; Chorionic somatomammotropin hormone 2; PL-II; Placental lactogen II; RPLII", "protein_names_refseq": "Placental lactogen-2; chorionic somatomammotropin hormone 2; growth hormone d15; placental lactogen 2; placental lactogen II; prolactin-3B1 precursor; prolactin-3B1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); impulse control disorder (Disease Ontology:DOID:10937); depressive disorder (Disease Ontology:DOID:1596); severe acute respiratory syndrome (Disease Ontology:DOID:2945); carotid artery disease (Disease Ontology:DOID:3407); prolactinoma (Disease Ontology:DOID:5394); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:24283)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12644299;16794002;2874144;9492027", "class_list": "", "function": "Circadian changes in placental lactogen-2 gene expression in the placenta., [RefSeq, PubMed]; Data support a role for AP2 gamma in the placental giant cell-specific expression of the placental lactogen II gene, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O70245;Q4QRC3", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P09321-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C172-1", "uniprot_id": [ { "id": "TIP39_RAT", "url": "https://www.uniprot.org/uniprot/P0C172", "type": "external" } ], "mass": 11022.0, "length": 100, "protein_name": "Tuberoinfundibular peptide of 39 residues", "gene_name": "Pth2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pth2; Tip39; Tipf39", "gene_names_refseq": "", "protein_names_uniprotkb": "Tuberoinfundibular peptide of 39 residues; Parathyroid hormone 2; TIP39", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-373080)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11818570;12508326;12559132", "class_list": "", "function": "Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C172-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C546-1", "uniprot_id": [ { "id": "S2542_RAT", "url": "https://www.uniprot.org/uniprot/P0C546", "type": "external" } ], "mass": 35100.0, "length": 318, "protein_name": "Mitochondrial coenzyme A transporter SLC25A42", "gene_name": "Slc25a42", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc25a42", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial coenzyme A transporter SLC25A42; Solute carrier family 25 member 42", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-199220)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16949250", "class_list": "", "function": "Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" } ], "go_molecular_function": "GO:0043262 ADP phosphatase activity;GO:0005347 ATP transmembrane transporter activity;GO:0015217 ADP transmembrane transporter activity;GO:0015228 coenzyme A transmembrane transporter activity;GO:0080122 AMP transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0015866 ADP transport;GO:0035349 coenzyme A transmembrane transport;GO:0080121 AMP transport;GO:0015867 ATP transport;GO:1990559 mitochondrial coenzyme A transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C546-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C6Y7-1", "uniprot_id": [ { "id": "PRDM9_RAT", "url": "https://www.uniprot.org/uniprot/P0C6Y7", "type": "external" } ], "mass": 92579.0, "length": 796, "protein_name": "Histone-lysine N-methyltransferase PRDM9", "gene_name": "Prdm9", "organism": "Rat", "refseq_name": "histone-lysine N-methyltransferase PRDM9", "refseq_ac": [ { "id": "NP_001102373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102373", "type": "external" } ], "gene_names_uniprotkb": "Prdm9", "gene_names_refseq": "Prdm7; Prdm9", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase PRDM9; 2.1.1.-; 2.1.1.354; 2.1.1.355; 2.1.1.359; 2.1.1.361; 2.1.1.362; PR domain zinc finger protein 9; PR domain-containing protein 9; Protein-lysine N-methyltransferase PRDM9; [histone H3]-lysine36 N-trimethyltransferase PRDM9; [histone H3]-lysine4 N-trimethyltransferase PRDM9; [histone H3]-lysine9 N-trimethyltransferase PRDM9; [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9; [histone H4]-lysine20 N-methyltransferase PRDM9", "protein_names_refseq": "PR domain 9; PR domain containing 7; PR domain containing 9; PR domain zinc finger protein 9; PR domain-containing protein 9; [histone H3]-lysine36 N-trimethyltransferase PRDM9; [histone H3]-lysine4 N-trimethyltransferase PRDM9; [histone H3]-lysine9 N-trimethyltransferase PRDM9; [histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9; [histone H4]-lysine20 N-methyltransferase PRDM9; histone-lysine N-methyltransferase PRDM9; protein-lysine N-methyltransferase PRDM9", "tax_id": 10116, "disease": "", "pathway": " (rno:365155); (R-RNO-212436); (R-RNO-3214841)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "27652271;35596034", "class_list": "", "function": "Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Can also methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate H3K9 with the di-methylated H3K9 as the best substrate. During meiotic prophase, binds specific DNA sequences through its zinc finger domains thereby determining hotspot localization where it promotes local H3K4me3 and H3K36me3 enrichment on the same nucleosomes through its histone methyltransferase activity. Thereby promotes double-stranded breaks (DSB) formation, at this subset of PRDM9-binding sites, that initiates meiotic recombination for the proper meiotic progression. During meiotic progression hotspot-bound PRDM9 interacts with several complexes; in early leptonema binds CDYL and EHMT2 followed by EWSR1 and CXXC1 by the end of leptonema. EWSR1 joins PRDM9 with the chromosomal axis through REC8. In this way, controls the DSB repair pathway, pairing of homologous chromosomes and sex body formation. Moreover plays a central role in the transcriptional activation of genes during early meiotic prophase thanks to H3K4me3 and H3K36me3 enrichment that represents a specific tag for epigenetic transcriptional activation. In addition performs automethylation. Acetylation and phosphorylation of histone H3 attenuate or prevent histone H3 methylation., [UniProtKB, UniProtKB]; Prdm9 deficiency of rat oocytes causes synapsis among non-homologous chromosomes and aneuploidy., [RefSeq, PubMed]; SET7/9 Recruitment to p21 Gene Promoter Was Increased under Diabetic Conditions, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0043565 sequence-specific DNA binding;GO:0042800 histone H3K4 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C6Y7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C7L8-1", "uniprot_id": [ { "id": "PPR3E_RAT", "url": "https://www.uniprot.org/uniprot/P0C7L8", "type": "external" } ], "mass": 30624.0, "length": 279, "protein_name": "Protein phosphatase 1 regulatory subunit 3E", "gene_name": "Ppp1r3e", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ppp1r3e", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 3E", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15752363", "class_list": "", "function": "Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding;GO:2001069 glycogen binding;GO:0050196 [phosphorylase] phosphatase activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0042587 glycogen granule", "go_biological_process": "GO:0005981 regulation of glycogen catabolic process;GO:0005977 glycogen metabolic process;GO:0045725 positive regulation of glycogen biosynthetic process;GO:0005979 regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C7L8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C7N0-1", "uniprot_id": [ { "id": "RWDD3_RAT", "url": "https://www.uniprot.org/uniprot/P0C7N0", "type": "external" } ], "mass": 30138.0, "length": 267, "protein_name": "RWD domain-containing protein 3", "gene_name": "Rwdd3", "organism": "Rat", "refseq_name": "RWD domain-containing protein 3", "refseq_ac": [ { "id": "NP_001121624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121624", "type": "external" } ], "gene_names_uniprotkb": "Rwdd3; Rsume", "gene_names_refseq": "Rsume; Rwdd3; X2cr1", "protein_names_uniprotkb": "RWD domain-containing protein 3; RSUME; RWD domain-containing sumoylation enhancer", "protein_names_refseq": "RWD domain-containing protein 3; RWD domain-containing sumoylation enhancer; RWD-containing sumoylation enhancer; pituitary tumor X2CR1 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:65026)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17956732", "class_list": "", "function": "Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Has no effect on ubiquitination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1902073 positive regulation of hypoxia-inducible factor-1alpha signaling pathway;GO:0033235 positive regulation of protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C7N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10164-1", "uniprot_id": [ { "id": "PRP2_RAT", "url": "https://www.uniprot.org/uniprot/P10164", "type": "external" } ], "mass": 17416.0, "length": 172, "protein_name": "Acidic proline-rich protein PRP25", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Acidic proline-rich protein PRP25", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3840480", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P10164-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10361-1", "uniprot_id": [ { "id": "P53_RAT", "url": "https://www.uniprot.org/uniprot/P10361", "type": "external" } ], "mass": 43451.0, "length": 391, "protein_name": "Cellular tumor antigen p53", "gene_name": "Tp53", "organism": "Rat", "refseq_name": "cellular tumor antigen p53 isoform a", "refseq_ac": [ { "id": "NP_112251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112251", "type": "external" } ], "gene_names_uniprotkb": "Tp53; P53", "gene_names_refseq": "Tp53; Trp53; p53", "protein_names_uniprotkb": "Cellular tumor antigen p53; Tumor suppressor p53", "protein_names_refseq": "cellular tumor antigen p53 isoform a; cellular tumor antigen p53; transformation related protein 53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressor p53", "tax_id": 10116, "disease": "angiosarcoma (Disease Ontology:DOID:0001816); pterygium (Disease Ontology:DOID:0002116); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); CHARGE syndrome (Disease Ontology:DOID:0050834); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colorectal carcinoma (Disease Ontology:DOID:0080199); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); traumatic brain injury (Disease Ontology:DOID:0081292); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); Li-Fraumeni syndrome 1 (Disease Ontology:DOID:0111503); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); aggressive NK-cell leukemia (Disease Ontology:DOID:1035); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); nasal cavity cancer (Disease Ontology:DOID:10811); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoma (Disease Ontology:DOID:1115); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); Graves' disease (Disease Ontology:DOID:12361); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); paranasal sinus benign neoplasm (Disease Ontology:DOID:1350); low tension glaucoma (Disease Ontology:DOID:13544); endometrial cancer (Disease Ontology:DOID:1380); disease of cellular proliferation (Disease Ontology:DOID:14566); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); basal cell carcinoma (Disease Ontology:DOID:2513); hematologic cancer (Disease Ontology:DOID:2531); choroid plexus papilloma (Disease Ontology:DOID:2626); transitional cell carcinoma (Disease Ontology:DOID:2671); dyskeratosis congenita (Disease Ontology:DOID:2729); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); testicular cancer (Disease Ontology:DOID:2998); Li-Fraumeni syndrome (Disease Ontology:DOID:3012); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); serous cystadenocarcinoma (Disease Ontology:DOID:3114); ischemia (Disease Ontology:DOID:326); osteosarcoma (Disease Ontology:DOID:3347); coronary artery disease (Disease Ontology:DOID:3393); cervical adenocarcinoma (Disease Ontology:DOID:3702); gastric adenocarcinoma (Disease Ontology:DOID:3717); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); coronary restenosis (Disease Ontology:DOID:4247); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); myelofibrosis (Disease Ontology:DOID:4971); ovary serous adenocarcinoma (Disease Ontology:DOID:5744); oral submucous fibrosis (Disease Ontology:DOID:5773); malignant peripheral nerve sheath tumor (Disease Ontology:DOID:5940); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575); meninges sarcoma (Disease Ontology:DOID:7614); vascular dementia (Disease Ontology:DOID:8725); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655)", "pathway": " (rno:24842); (R-RNO-2559580); (R-RNO-2559584); (R-RNO-2559585); (R-RNO-2559586); (R-RNO-349425); (R-RNO-5689880); (R-RNO-5689896); (R-RNO-5693565); (R-RNO-6804754); (R-RNO-6804756); (R-RNO-6804757); (R-RNO-6804758); (R-RNO-6804759); (R-RNO-6804760); (R-RNO-6811555); (R-RNO-69473); (R-RNO-69481); (R-RNO-69541); (R-RNO-69895); (R-RNO-8852276); (R-RNO-8941855); (R-RNO-9833482)", "pathway_count": 23, "publication_count": 11, "publication_id_list": "22726440;3060862;32810137;37580538;37935918;38168028;38288820;39094671;8441680;8663025;9278438", "class_list": "", "function": "1,25-D3 ameliorates ischemic brain injury by alleviating endoplasmic reticulum stress and ferroptosis: Involvement of vitamin D receptor and p53 signaling., [RefSeq, PubMed]; Acetylation of p53 in the Cerebral Cortex after Photothrombotic Stroke., [RefSeq, PubMed]; BANP Participates in the Chronic Intermittent Hypoxia-Induced Senescence of Vascular Endothelial Cells by Promoting P53 Phosphorylation and Nuclear Retention., [RefSeq, PubMed]; Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mutant p53[R211*] ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response., [RefSeq, PubMed]; P53-induced GAP-43 Upregulation in Primary Cortical Neurons of Rats., [RefSeq, PubMed]; This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it is believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. p53 pseudogenes have been found on chromosomes 9 and 18. [provided by RefSeq, May 2024]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 79, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O09168;Q4KMA9;Q66HM0", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0071401 cellular response to triglyceride;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P10361-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10760-1", "uniprot_id": [ { "id": "SAHH_RAT", "url": "https://www.uniprot.org/uniprot/P10760", "type": "external" } ], "mass": 47538.0, "length": 432, "protein_name": "Adenosylhomocysteinase", "gene_name": "Ahcy", "organism": "Rat", "refseq_name": "adenosylhomocysteinase", "refseq_ac": [ { "id": "NP_058897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058897", "type": "external" } ], "gene_names_uniprotkb": "Ahcy", "gene_names_refseq": "Ahcy", "protein_names_uniprotkb": "Adenosylhomocysteinase; 3.13.2.1; AdoHcyase; S-adenosyl-L-homocysteine hydrolase", "protein_names_refseq": "S-adenosyl-L-homocysteine hydrolase; S-adenosylhomocysteine hydrolase; adenosylhomocysteinase; adoHcyase", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase (Disease Ontology:DOID:0111039); abdominal aortic aneurysm (Disease Ontology:DOID:7693); pyridoxine deficiency anemia (Disease Ontology:DOID:8455); hyperhomocysteinemia (Disease Ontology:DOID:9279); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:29443); (R-RNO-156581); (R-RNO-1614635)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10387078;10913437;11741948;11927587;19805518;3027698;3759971;7744082", "class_list": "", "function": "Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:11927587). Binds copper ions (By similarity)., [UniProtKB, UniProtKB, PubMed]; Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine. Binds copper ions., [UniProtKB, UniProtKB]; Report that Myc promotes upregulation of S-adenosyl homocysteine hydrolase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.13.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.13.2.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051287 NAD binding;GO:0005507 copper ion binding;GO:0004013 adenosylhomocysteinase activity;GO:0030554 adenyl nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0042470 melanosome", "go_biological_process": "GO:0007584 response to nutrient;GO:0001666 response to hypoxia;GO:0006730 one-carbon metabolic process;GO:0002439 chronic inflammatory response to antigenic stimulus;GO:0019510 S-adenosylhomocysteine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10760-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11232-1", "uniprot_id": [ { "id": "THIO_RAT", "url": "https://www.uniprot.org/uniprot/P11232", "type": "external" } ], "mass": 11673.0, "length": 105, "protein_name": "Thioredoxin", "gene_name": "Txn", "organism": "Rat", "refseq_name": "thioredoxin", "refseq_ac": [ { "id": "NP_446252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446252", "type": "external" } ], "gene_names_uniprotkb": "Txn; Txn1", "gene_names_refseq": "Txn1; Txn", "protein_names_uniprotkb": "Thioredoxin; Trx", "protein_names_refseq": "contains a redox-active disulphide (-Cys-Gly-Pro-Cys-) and has multiple biological functions as a hydrogen donor; thioredoxin; trx", "tax_id": 10116, "disease": "", "pathway": " (rno:116484); (R-RNO-2559580); (R-RNO-3299685); (R-RNO-499943); (R-RNO-5628897); (R-RNO-5676934); (R-RNO-844456)", "pathway_count": 7, "publication_count": 8, "publication_id_list": "21454685;2734107;34132424;35072836;37196136;37816196;38976128;7818492", "class_list": "", "function": "Aldehyde Dehydrogenase 2 Preserves Mitochondrial Function in the Ischemic Heart: A Redox-dependent Mechanism for AMPK Activation by Thioredoxin-1. Publication Status: Online-Only, [RefSeq, PubMed]; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity)., [UniProtKB]; Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer's Disease. Erratum:[Mol Neurobiol. 2025 May;62(5):6626. doi: 10.1007/s12035-024-04523-8. PMID: 39333348], [RefSeq, PubMed]; Thioredoxin-1 inhibits amyloid-beta25-35-induced activation of NLRP1/caspase-1/GSDMD pyroptotic pathway in PC12 cells., [RefSeq, PubMed]; Thioredoxin-1 regulates calcium homeostasis in MPP(+) /MPTP-induced Parkinson's disease models., [RefSeq, PubMed]; Thioredoxin1 Binding Metastasis-Associated Lung Adenocarcinoma Transcript 1 Attenuates Inflammation and Apoptosis after Intracerebral Hemorrhage. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0015035 protein-disulfide reductase activity;GO:0047134 protein-disulfide reductase [NAD(P)H] activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0097068 response to thyroxine;GO:0006351 DNA-templated transcription;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0071333 cellular response to glucose stimulus;GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P11232-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11661-1", "uniprot_id": [ { "id": "NU5M_RAT", "url": "https://www.uniprot.org/uniprot/P11661", "type": "external" } ], "mass": 68618.0, "length": 609, "protein_name": "NADH-ubiquinone oxidoreductase chain 5", "gene_name": "Mt-nd5", "organism": "Rat", "refseq_name": "NADH dehydrogenase subunit 5", "refseq_ac": [ { "id": "YP_665639", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_665639", "type": "external" } ], "gene_names_uniprotkb": "Mt-nd5; Mtnd5; Nd5", "gene_names_refseq": "ND5", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 5; 7.1.1.2; NADH dehydrogenase subunit 5", "protein_names_refseq": "NADH dehydrogenase subunit 5", "tax_id": 10116, "disease": "Leigh disease (Disease Ontology:DOID:3652); MELAS syndrome (Disease Ontology:DOID:3687); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (rno:26202); (R-RNO-5419276); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "2504926", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0001666 response to hypoxia;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0042542 response to hydrogen peroxide;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0015990 electron transport coupled proton transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P11661-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13286-1", "uniprot_id": [ { "id": "PHKG1_RAT", "url": "https://www.uniprot.org/uniprot/P13286", "type": "external" } ], "mass": 45015.0, "length": 388, "protein_name": "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform", "gene_name": "Phkg1", "organism": "Rat", "refseq_name": "phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform", "refseq_ac": [ { "id": "NP_113761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113761", "type": "external" } ], "gene_names_uniprotkb": "Phkg1; Phkg", "gene_names_refseq": "PHKIN01; Phkg1; Phkg", "protein_names_uniprotkb": "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; 2.7.11.19; 2.7.11.1; 2.7.11.26; Phosphorylase kinase subunit gamma-1; Serine/threonine-protein kinase PHKG1", "protein_names_refseq": "gamma phosphorylase kinase; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; phosphorylase kinase subunit gamma-1; phosphorylase kinase, gamma 1; serine/threonine-protein kinase PHKG1", "tax_id": 10116, "disease": "congenital chylothorax (Disease Ontology:DOID:0060646)", "pathway": " (rno:29353); (R-RNO-70221)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "3357797;8419323", "class_list": "", "function": "Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004689 phosphorylase kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005964 phosphorylase kinase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0005977 glycogen metabolic process;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P13286-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13383-1", "uniprot_id": [ { "id": "NUCL_RAT", "url": "https://www.uniprot.org/uniprot/P13383", "type": "external" } ], "mass": 77147.0, "length": 713, "protein_name": "Nucleolin", "gene_name": "Ncl", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ncl; Nuc", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleolin; Protein C23", "protein_names_refseq": "", "tax_id": 10116, "disease": "lipoid proteinosis (Disease Ontology:DOID:14498)", "pathway": " (rno:25135); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16641100;22673903;2347493;2906027", "class_list": "", "function": "Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 0, "predicted_o_glycosites": 7, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035368 selenocysteine insertion sequence binding;GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005938 cell cortex;GO:0009986 cell surface", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:2000232 regulation of rRNA processing;GO:0001525 angiogenesis;GO:0006897 endocytosis;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P13383-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13668-1", "uniprot_id": [ { "id": "STMN1_RAT", "url": "https://www.uniprot.org/uniprot/P13668", "type": "external" } ], "mass": 17288.0, "length": 149, "protein_name": "Stathmin", "gene_name": "LOC102551813; Stmn1", "organism": "Rat", "refseq_name": "stathmin", "refseq_ac": [ { "id": "NP_058862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058862", "type": "external" } ], "gene_names_uniprotkb": "LOC102551813; Stmn1; LOC102551813; Lap18; Stmn1", "gene_names_refseq": "Lap18; OP18; PP17; PP19; PR22; SMN; Stmn1; prosolin", "protein_names_uniprotkb": "Stathmin; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; Pr22 protein; Prosolin; pp17; pp19", "protein_names_refseq": "leukemia-associated phosphoprotein p18; metablastin; oncoprotein 18; phosphoprotein p19; stathmin", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:29332)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16110469;16982419;22673903;25285524;26370173;2745432;2776625;31933182;7935347;8376365;9629929", "class_list": "", "function": "Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules (By similarity). Its phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity)., [UniProtKB, PubMed]; Stathmin Regulates Spatiotemporal Variation in the Memory Loop in Single-Prolonged Stress Rats., [RefSeq, PubMed]; Stathmin is enriched in the developing corticospinal tract, [RefSeq, PubMed]; Stathmin therefore mediates hepatocyte resistance to death from oxidative stress by down regulating JNK and maintaining mitochondrial integrity Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016020 membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0007409 axonogenesis;GO:0031175 neuron projection development;GO:0035556 intracellular signal transduction;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P13668-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13852-1", "uniprot_id": [ { "id": "PRIO_RAT", "url": "https://www.uniprot.org/uniprot/P13852", "type": "external" } ], "mass": 27804.0, "length": 254, "protein_name": "Major prion protein", "gene_name": "Prnp", "organism": "Rat", "refseq_name": "major prion protein precursor", "refseq_ac": [ { "id": "NP_036763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036763", "type": "external" } ], "gene_names_uniprotkb": "Prnp; Prn; Prp", "gene_names_refseq": "PrP; Prnp; Prn", "protein_names_uniprotkb": "Major prion protein; PrP", "protein_names_refseq": "major prion protein precursor; major prion protein; prion protein, PrP; prion protein, structural", "tax_id": 10116, "disease": "fatal familial insomnia (Disease Ontology:DOID:0050433); Huntington's disease-like 1 (Disease Ontology:DOID:0090103); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); hyperglycemia (Disease Ontology:DOID:4195); Gerstmann-Straussler-Scheinker syndrome (Disease Ontology:DOID:4249); scrapie (Disease Ontology:DOID:5434); kuru (Disease Ontology:DOID:648)", "pathway": " (rno:24686); (R-RNO-9609523)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10373359;2889848;37819170;38843836;7909925;8879116", "class_list": "", "function": "Cellular Prion protein moonlights vascular smooth muscle cell fate: Surveilled by trophoblast cells., [RefSeq, PubMed]; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q549H6", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0002020 protease binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0032700 negative regulation of interleukin-17 production;GO:0032703 negative regulation of interleukin-2 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P13852-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14423-1", "uniprot_id": [ { "id": "PA2GA_RAT", "url": "https://www.uniprot.org/uniprot/P14423", "type": "external" } ], "mass": 16294.0, "length": 146, "protein_name": "Phospholipase A2, membrane associated", "gene_name": "Pla2g2a", "organism": "Rat", "refseq_name": "phospholipase A2, membrane associated precursor", "refseq_ac": [ { "id": "NP_113786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113786", "type": "external" } ], "gene_names_uniprotkb": "Pla2g2a", "gene_names_refseq": "Pla2g2a; sPLA2", "protein_names_uniprotkb": "Phospholipase A2, membrane associated; 3.1.1.4; GIIC sPLA2; Group IIA phospholipase A2; Phosphatidylcholine 2-acylhydrolase 2A", "protein_names_refseq": "GIIC sPLA2; eted enzyme type IIA phospholipase A2; group IIA phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; phospholipase A2, group IIA (platelets, synovial fluid); phospholipase A2, membrane associated precursor; phospholipase A2, membrane associated; platelet phospholipase A2", "tax_id": 10116, "disease": "cholecystolithiasis (Disease Ontology:DOID:11151); allergic conjunctivitis (Disease Ontology:DOID:11204); adult respiratory distress syndrome (Disease Ontology:DOID:11394); depressive disorder (Disease Ontology:DOID:1596); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); gastroesophageal reflux disease (Disease Ontology:DOID:8534); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:29692); (R-RNO-1482788); (R-RNO-1482801); (R-RNO-1482839); (R-RNO-1482922); (R-RNO-1482925); (R-RNO-1483166); (R-RNO-6803157)", "pathway_count": 8, "publication_count": 11, "publication_id_list": "2346480;23629656;2400792;2606907;26162096;2722857;2764915;3235451;32881777;3356705;3654593", "class_list": "", "function": "A novel inverse recruitment mechanism in which liganded TRbeta recruits corepressors to inhibit PLA2g2a expression., [RefSeq, PubMed]; Immediate inhibition of spinal secretory phospholipase A2 prevents the pain and elevated spinal neuronal hyperexcitability and neuroimmune regulatory genes that develop with nerve root compression., [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration (By similarity). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:3356705). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response (By similarity). Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; The present study was designed to determine the relationship between phenformin coupling AMP-activated protein kinase (AMPK) function and the molecular mechanism by which the sPLA2 IIA expression was modulated in vascular smooth muscle cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0046473 phosphatidic acid metabolic process;GO:0050678 regulation of epithelial cell proliferation;GO:0006954 inflammatory response;GO:0008285 negative regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P14423-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14730-1", "uniprot_id": [ { "id": "WFD18_RAT", "url": "https://www.uniprot.org/uniprot/P14730", "type": "external" } ], "mass": 7740.0, "length": 74, "protein_name": "WAP four-disulfide core domain protein 18", "gene_name": "Wfdc18", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wfdc18; Expi; Wdnm1", "gene_names_refseq": "", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 18; Extracellular peptidase inhibitor; Protein WDNM1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:171059)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2018519;3136918", "class_list": "", "function": "Involved in the metastatic potential of adenocarcinomas in rat. Could have proteinase inhibiting capacity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0030414 peptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P14730-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15399-1", "uniprot_id": [ { "id": "PBAS_RAT", "url": "https://www.uniprot.org/uniprot/P15399", "type": "external" } ], "mass": 20780.0, "length": 177, "protein_name": "Probasin", "gene_name": "Pbsn", "organism": "Rat", "refseq_name": "probasin precursor", "refseq_ac": [ { "id": "NP_061998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061998", "type": "external" } ], "gene_names_uniprotkb": "Pbsn; Prbs", "gene_names_refseq": "PB; Pbsn", "protein_names_uniprotkb": "Probasin; M-40; PB", "protein_names_refseq": "M-40; probasin precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:54193)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11058766;11895861;14500578;2682630", "class_list": "", "function": "Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression under probasin gene promoter control, [RefSeq, PubMed]; The -705/+28 PB promoter contains a second androgen response region, PB enhancer element (-705/-426 PB), in addition to the first, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53Z30", "ec_number_list": [], "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P15399-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16610-1", "uniprot_id": [ { "id": "NK2R_RAT", "url": "https://www.uniprot.org/uniprot/P16610", "type": "external" } ], "mass": 43853.0, "length": 390, "protein_name": "Substance-K receptor", "gene_name": "Tacr2", "organism": "Rat", "refseq_name": "substance-K receptor", "refseq_ac": [ { "id": "NP_542946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542946", "type": "external" } ], "gene_names_uniprotkb": "Tacr2; Tac2r", "gene_names_refseq": "Tac2r; Tacr2", "protein_names_uniprotkb": "Substance-K receptor; NK-2 receptor; NK-2R; Neurokinin A receptor; SKR; Tachykinin receptor 2", "protein_names_refseq": "NK-2 receptor; NK-2R; SKR; Tachykinin 2 (substance K) receptor; neurokinin A receptor; substance-K receptor", "tax_id": 10116, "disease": "colitis (Disease Ontology:DOID:0060180); asthma (Disease Ontology:DOID:2841); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (rno:25007); (R-RNO-380095); (R-RNO-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1370820;19854231;20882546;2480781;30711443", "class_list": "", "function": "Data show that injection of vehicle alone into the medial septum impaired memory for temporal order and spatial location, while the NK(2) receptor antagonist partially reversed this deficit by reinstating memory for temporal order., [RefSeq, PubMed]; Receptor for the tachykinin substance K (neurokinin A), also able to bind and respond to tachynins substance P and neurokinin B/neuromedin-K (PubMed:1370820). The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P (PubMed:1370820). Substance K binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C (PubMed:1370820). Substance K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (PubMed:1370820)., [UniProtKB, PubMed]; Stress-induced increase in Tacr2 expression in the hypothalamus correlated with a specific decrease in DNA methylation of the Tacr2 gene., [RefSeq, PubMed]; These results indicate that medial septal NK(2)-R have an important role in mediating acetylcholine release, for one, via the septal-hippocampal cholinergic projection and, secondly, via direct or indirect route to the amygdala, but not frontal cortex., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016497 substance K receptor activity", "go_cellular_component": "GO:0061827 sperm head;GO:0005886 plasma membrane;GO:0036126 sperm flagellum;GO:0097225 sperm midpiece", "go_biological_process": "GO:0035106 operant conditioning;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0043270 positive regulation of monoatomic ion transport;GO:0014057 positive regulation of acetylcholine secretion, neurotransmission;GO:0014827 intestine smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P16610-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17136-1", "uniprot_id": [ { "id": "RSMB_RAT", "url": "https://www.uniprot.org/uniprot/P17136", "type": "external" } ], "mass": 23656.0, "length": 231, "protein_name": "Small nuclear ribonucleoprotein-associated protein B", "gene_name": "Snrpb", "organism": "Rat", "refseq_name": "small nuclear ribonucleoprotein-associated protein B", "refseq_ac": [ { "id": "NP_599185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599185", "type": "external" } ], "gene_names_uniprotkb": "Snrpb", "gene_names_refseq": "Snrpb", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein-associated protein B; SM11; Sm protein B; Sm-B; SmB; snRNP-B; snRPB", "protein_names_refseq": "SM11; sm protein B; sm-B; smB; small nuclear ribonucleoprotein-associated protein B; snRNP-B", "tax_id": 10116, "disease": "cerebrocostomandibular syndrome (Disease Ontology:DOID:0111248); mixed connective tissue disease (Disease Ontology:DOID:3492); lung adenocarcinoma (Disease Ontology:DOID:3910); tauopathy (Disease Ontology:DOID:680)", "pathway": " (rno:171365); (R-RNO-111367); (R-RNO-191859); (R-RNO-72163); (R-RNO-72165); (R-RNO-73856); (R-RNO-77588); (R-RNO-9770562); (R-RNO-9943411)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "2532363", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B0BN51", "ec_number_list": [], "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003723 RNA binding;GO:0070990 snRNP binding;GO:0070034 telomerase RNA binding;GO:0071208 histone pre-mRNA DCP binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006479 protein methylation;GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P17136-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17438-1", "uniprot_id": [ { "id": "PRPH2_RAT", "url": "https://www.uniprot.org/uniprot/P17438", "type": "external" } ], "mass": 39267.0, "length": 346, "protein_name": "Peripherin-2", "gene_name": "Prph2", "organism": "Rat", "refseq_name": "peripherin-2", "refseq_ac": [ { "id": "NP_037153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037153", "type": "external" } ], "gene_names_uniprotkb": "Prph2; Rds", "gene_names_refseq": "Prph2; RSRDS; Rds", "protein_names_uniprotkb": "Peripherin-2; Retinal degeneration slow protein", "protein_names_refseq": "peripherin-2; retinal degeneration slow protein; retinal degeneration, slow", "tax_id": 10116, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); patterned macular dystrophy (Disease Ontology:DOID:0060863); patterned macular dystrophy 1 (Disease Ontology:DOID:0060866); retinitis pigmentosa 7 (Disease Ontology:DOID:0110383); retinitis pigmentosa (Disease Ontology:DOID:10584); fundus albipunctatus (Disease Ontology:DOID:11105); Leber congenital amaurosis (Disease Ontology:DOID:14791); macular degeneration (Disease Ontology:DOID:4448); retinal disease (Disease Ontology:DOID:5679); retinal degeneration (Disease Ontology:DOID:8466); choroidal sclerosis (Disease Ontology:DOID:980); partial central choroid dystrophy (Disease Ontology:DOID:9822)", "pathway": " (rno:25534)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2349107", "class_list": "", "function": "Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0009645 response to low light intensity stimulus;GO:0007155 cell adhesion;GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P17438-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19103-1", "uniprot_id": [ { "id": "PPR1A_RAT", "url": "https://www.uniprot.org/uniprot/P19103", "type": "external" } ], "mass": 18738.0, "length": 171, "protein_name": "Protein phosphatase 1 regulatory subunit 1A", "gene_name": "Ppp1r1a", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 1A", "refseq_ac": [ { "id": "NP_073167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073167", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r1a; Ipp1", "gene_names_refseq": "Ppp1r1a", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 1A; I-1; IPP-1; Protein phosphatase inhibitor 1", "protein_names_refseq": "I-1; IPP-1; PP1 inhibitor 1; protein phosphatase 1 regulatory subunit 1A; protein phosphatase inhibitor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:58977)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11269652;11278334;16774736;1696252;19377265;21149637;21447388;22673903;25416155", "class_list": "", "function": "Calcineurin and protein phosphatase-2A act to maintain a low basal level of phosphorylated (active) phosphatase inhibitor-1 in living cardiac myocytes, [RefSeq, PubMed]; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protein phosphatase inhibitor-1 augments a protein kinase A-dependent increase in the Ca2+ loading of the sarcoplasmic reticulum without changing its Ca2+ release., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DSU5", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0005977 glycogen metabolic process;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P19103-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20267-1", "uniprot_id": [ { "id": "PO3F1_RAT", "url": "https://www.uniprot.org/uniprot/P20267", "type": "external" } ], "mass": 45496.0, "length": 451, "protein_name": "POU domain, class 3, transcription factor 1", "gene_name": "Pou3f1", "organism": "Rat", "refseq_name": "POU domain, class 3, transcription factor 1", "refseq_ac": [ { "id": "NP_620193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620193", "type": "external" } ], "gene_names_uniprotkb": "Pou3f1; Oct-6; Otf-6; Otf6; Scip", "gene_names_refseq": "Oct-6; Otf6; Pou3f1; Scip; Testes-1; Tst-1", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 1; OTF-6; Oct-6; Octamer-binding protein 6; Octamer-binding transcription factor 6; POU domain transcription factor SCIP; Tst-1", "protein_names_refseq": "OTF-6; POU domain transcription factor SCIP; POU domain, class 3, transcription factor 1; octamer-binding protein 6; octamer-binding transcription factor 6; octoamer transcription factor-6; octomer-6; suppressed cAMP-inducible POU", "tax_id": 10116, "disease": "", "pathway": " (rno:192110)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1705013;18683930;1975954;21653862;2739723", "class_list": "", "function": "Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). Acts as a transcriptional repressor of myelin-specific genes (PubMed:1975954)., [UniProtKB, UniProtKB, PubMed]; We propose that Sox10-dependent activation of Oct6 defines a feedforward regulatory module that serves to time and amplify the onset of myelination in the peripheral nervous system., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0030900 forebrain development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P20267-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21670-1", "uniprot_id": [ { "id": "PSA4_RAT", "url": "https://www.uniprot.org/uniprot/P21670", "type": "external" } ], "mass": 29498.0, "length": 261, "protein_name": "Proteasome subunit alpha type-4", "gene_name": "Psma4", "organism": "Rat", "refseq_name": "proteasome subunit alpha type-4", "refseq_ac": [ { "id": "NP_058977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058977", "type": "external" } ], "gene_names_uniprotkb": "Psma4", "gene_names_refseq": "Psma4", "protein_names_uniprotkb": "Proteasome subunit alpha type-4; Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; Proteasome component C9; Proteasome subunit L; Proteasome subunit alpha-3; alpha-3", "protein_names_refseq": "alpha-3; macropain subunit C9; multicatalytic endopeptidase complex subunit C9; multicatalytic proteinase subunit L; proteasome (prosome, macropain) subunit, alpha type 4; proteasome alpha 4 subunit; proteasome component C9; proteasome subunit L; proteasome subunit alpha 4; proteasome subunit alpha type-4; proteasome subunit alpha-3", "tax_id": 10116, "disease": "", "pathway": " (rno:29671); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 58, "publication_count": 3, "publication_id_list": "15987638;2249692;2358075", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, UniProtKB]; Parkin interacts with the proteasome subunit alpha4, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P21670-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21702-1", "uniprot_id": [ { "id": "PR3D1_RAT", "url": "https://www.uniprot.org/uniprot/P21702", "type": "external" } ], "mass": 26324.0, "length": 230, "protein_name": "Prolactin-3D1", "gene_name": "Prl3d1; Prl3d2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prl3d1; Prl3d2; Csh1; Pl1; Prl3d1", "gene_names_refseq": "", "protein_names_uniprotkb": "Prolactin-3D1; Chorionic somatomammotropin hormone 1; PL-I; Placental lactogen I", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2373051", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P21702-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22006-1", "uniprot_id": [ { "id": "SVS2_RAT", "url": "https://www.uniprot.org/uniprot/P22006", "type": "external" } ], "mass": 45539.0, "length": 414, "protein_name": "Seminal vesicle secretory protein 2", "gene_name": "Semg1; Svs2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Semg1; Svs2", "gene_names_refseq": "", "protein_names_uniprotkb": "Seminal vesicle secretory protein 2; SVS II; Seminal vesicle secretory protein II", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:25013)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2351680", "class_list": "", "function": "The rat seminal vesicle contains six major androgen-dependent secretory proteins referred to as SVS I-VI. The SVS I-III proteins appear to be components of the rat copulatory plug, with the SVS II protein being the major component., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0001669 acrosomal vesicle;GO:0032991 protein-containing complex", "go_biological_process": "GO:0090281 negative regulation of calcium ion import;GO:1901318 negative regulation of flagellated sperm motility;GO:0009566 fertilization;GO:0019731 antibacterial humoral response;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P22006-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22355-1", "uniprot_id": [ { "id": "PSPB_RAT", "url": "https://www.uniprot.org/uniprot/P22355", "type": "external" } ], "mass": 41590.0, "length": 376, "protein_name": "Pulmonary surfactant-associated protein B", "gene_name": "Sftpb", "organism": "Rat", "refseq_name": "pulmonary surfactant-associated protein B precursor", "refseq_ac": [ { "id": "NP_620197", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620197", "type": "external" } ], "gene_names_uniprotkb": "Sftpb; Sftp3", "gene_names_refseq": "Sftpb; Sp-b", "protein_names_uniprotkb": "Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteolipid SPL(Phe); SP-B", "protein_names_refseq": "pulmonary surfactant-associated protein B precursor; pulmonary surfactant-associated protein B; pulmonary surfactant-associated proteolipid SPL(Phe); surfactant associated protein B; surfactant, pulmonary-associated protein B", "tax_id": 10116, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); respiratory failure (Disease Ontology:DOID:11162); adult respiratory distress syndrome (Disease Ontology:DOID:11394); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); pulmonary alveolar proteinosis (Disease Ontology:DOID:12120); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); lung cancer (Disease Ontology:DOID:1324); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pneumonia (Disease Ontology:DOID:552); lung disease (Disease Ontology:DOID:850); bacterial pneumonia (Disease Ontology:DOID:874); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:192155); (R-RNO-5683826)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "2920185;30341519;33248225;38483982", "class_list": "", "function": "Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Recombinant expression of the precursor of rat lung surfactant protein B in Escherichia coli and its antibacterial mechanism., [RefSeq, PubMed]; The expression of SP-B and SP-C in GDM group was significantly reduced as compared with control group (P<0.05)... It was concluded that gestational diabetes mellitus can cause fetal lung development and maturation disorders, and FOXA2 in fetal lung tissue decreases while nitrocellulose FOXA2 increases, [RefSeq, PubMed]; The expression of the surfactant proteins SP-A and SP-B during postnatal alveolarization of the rat lung. Erratum:[PLoS One. 2025 Aug 6;20(8):e0329954. doi: 10.1371/journal.pone.0329954. PMID: 40768498] Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0005764 lysosome;GO:0097208 alveolar lamellar body", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0043129 surfactant homeostasis;GO:0001666 response to hypoxia;GO:0006665 sphingolipid metabolic process;GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P22355-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23358-1", "uniprot_id": [ { "id": "RL12_RAT", "url": "https://www.uniprot.org/uniprot/P23358", "type": "external" } ], "mass": 17846.0, "length": 165, "protein_name": "Large ribosomal subunit protein uL11", "gene_name": "Rpl12", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL11", "refseq_ac": [ { "id": "NP_001102668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102668", "type": "external" } ], "gene_names_uniprotkb": "Rpl12", "gene_names_refseq": "RL12; Rpl12", "protein_names_uniprotkb": "Large ribosomal subunit protein uL11; 60S ribosomal protein L12", "protein_names_refseq": "60S ribosomal protein L12; large ribosomal subunit protein uL11", "tax_id": 10116, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:499782); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "1977388", "class_list": "", "function": "Component of the large ribosomal subunit (By similarity). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (By similarity). Binds directly to 26S ribosomal RNA (PubMed:1977388)., [UniProtKB, UniProtKB, PubMed]; Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds directly to 26S ribosomal RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0045202 synapse", "go_biological_process": "GO:0006412 translation;GO:0045901 positive regulation of translational elongation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P23358-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23978-1", "uniprot_id": [ { "id": "SC6A1_RAT", "url": "https://www.uniprot.org/uniprot/P23978", "type": "external" } ], "mass": 67001.0, "length": 599, "protein_name": "Sodium- and chloride-dependent GABA transporter 1", "gene_name": "Slc6a1", "organism": "Rat", "refseq_name": "sodium- and chloride-dependent GABA transporter 1", "refseq_ac": [ { "id": "NP_077347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077347", "type": "external" } ], "gene_names_uniprotkb": "Slc6a1; Gabt1; Gat-1; Gat1", "gene_names_refseq": "Gabt1; Gat1; Slc6a1", "protein_names_uniprotkb": "Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1", "protein_names_refseq": "GABA transporter protein; sodium- and chloride-dependent GABA transporter 1; solute carrier family 6 (neurotransmitter transporter), member 1; solute carrier family 6 (neurotransmitter transporter, GABA), member 1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); temporal lobe epilepsy (Disease Ontology:DOID:3328); cerebral infarction (Disease Ontology:DOID:3526); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:79212); (R-RNO-442660); (R-RNO-888593)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15234345;18054861;1975955;21775701;22673903;25798861;26390912;30790582;9169433", "class_list": "", "function": "Epileptiform activity is associated with increased synaptic GABA release and is not accompanied by GAT-1 reversal. Sustained efflux of GABA through GAT-1 is unlikely to occur during physiological or pathological network activity. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:18054861, PubMed:1975955). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (PubMed:18054861, PubMed:21775701). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (PubMed:18054861, PubMed:21775701). Also mediates sodium- and chloride-dependent transport of hypotaurine (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Perturbation of the internal gate of GAT1 selectively impairs the gating mechanism of the empty transporter, [RefSeq, PubMed]; Study demonstrated that GAT1 and GAT3 were expressed in glial cells but not at detectable levels in suprachiasmatic hypothalamic nucleus neurons, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005283 amino acid:sodium symporter activity;GO:0015378 sodium:chloride symporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007612 learning;GO:0007613 memory;GO:0008306 associative learning;GO:0010288 response to lead ion;GO:0014074 response to purine-containing compound", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P23978-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24008-1", "uniprot_id": [ { "id": "S5A1_RAT", "url": "https://www.uniprot.org/uniprot/P24008", "type": "external" } ], "mass": 29780.0, "length": 259, "protein_name": "3-oxo-5-alpha-steroid 4-dehydrogenase 1", "gene_name": "Srd5a1", "organism": "Rat", "refseq_name": "3-oxo-5-alpha-steroid 4-dehydrogenase 1", "refseq_ac": [ { "id": "NP_058766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058766", "type": "external" } ], "gene_names_uniprotkb": "Srd5a1", "gene_names_refseq": "S5AR 1; Srd5a1", "protein_names_uniprotkb": "3-oxo-5-alpha-steroid 4-dehydrogenase 1; 1.3.1.22; S5AR 1; SR type 1; Steroid 5-alpha-reductase 1", "protein_names_refseq": "3-oxo-5-alpha-steroid 4-dehydrogenase 1; SR type 1; steroid 5-alpha-reductase; steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); prostate cancer (Disease Ontology:DOID:10283); prostatic hypertrophy (Disease Ontology:DOID:11132); hyperprolactinemia (Disease Ontology:DOID:12700); hypothyroidism (Disease Ontology:DOID:1459); breast carcinoma (Disease Ontology:DOID:3459); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24950); (R-RNO-193048)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "2339109;23405234;2476440;25239636;26021641;28707553;8597599", "class_list": "", "function": "Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed:2339109). Converts testosterone into 5-alpha-dihydrotestosterone (DHT), a more potent androgen as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual differentiation during development (PubMed:2339109). Besides testosterone, it can also act on other steroids, including progesterone, androstenedione, and corticoids, producing metabolites with diverse roles (PubMed:2339109). Hence, it plays a central role in sexual differentiation and androgen physiology (By similarity)., [UniProtKB, PubMed, UniProtKB]; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology., [UniProtKB, PubMed]; Exposure of middle-aged rats to environmental enrichment increased mRNA levels of 5al;pha-reductase-1, 3alpha-HSD and cytochrome P450 17alpha-hydroxylase/c17,20-lyase and decreased the methylation state of the 5alpha-reductase-1 gene, [RefSeq, PubMed]; Low Srd5a1 expression is associated with benign prostatic hypertrophy., [RefSeq, PubMed]; The effects of deficiency or inhibition of S5AR1 on the risk of liver disease and insulin resistance in male rats and mice are reported., [RefSeq, PubMed]; Ziram inhibited SRD5A1 and AKR1C14 activities, thus possibly interfering with neurosteroid production in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JPJ6", "ec_number_list": [ { "id": "1.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.22", "type": "external" }, { "id": "1.3.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94", "type": "external" } ], "go_molecular_function": "GO:0033218 amide binding;GO:0070402 NADPH binding;GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0070852 cell body fiber", "go_biological_process": "GO:0006710 androgen catabolic process;GO:0030540 female genitalia development;GO:0046661 male sex differentiation;GO:0001889 liver development;GO:0021510 spinal cord development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P24008-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25113-1", "uniprot_id": [ { "id": "PGAM1_RAT", "url": "https://www.uniprot.org/uniprot/P25113", "type": "external" } ], "mass": 28832.0, "length": 254, "protein_name": "Phosphoglycerate mutase 1", "gene_name": "Pgam1", "organism": "Rat", "refseq_name": "phosphoglycerate mutase 1", "refseq_ac": [ { "id": "NP_445742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445742", "type": "external" } ], "gene_names_uniprotkb": "Pgam1", "gene_names_refseq": "PGAM-B; Pgam1; Pgmut", "protein_names_uniprotkb": "Phosphoglycerate mutase 1; 5.4.2.11; 5.4.2.4; BPG-dependent PGAM 1; PGAM-B; Phosphoglycerate mutase isozyme B", "protein_names_refseq": "BPG-dependent PGAM 1; phosphoglycerate mutase 1 (brain); phosphoglycerate mutase 1; phosphoglycerate mutase isozyme B", "tax_id": 10116, "disease": "degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (rno:24642); (R-RNO-6798695); (R-RNO-70171); (R-RNO-70263)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "1533381;16641100;1832843;18533197;18683930;22420779;22673903;34502162", "class_list": "", "function": "Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate, a crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate., [UniProtKB, UniProtKB]; Data show statistically significant altered levels of Tpi1 and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline significance in phencyclidine (PCP) rats compared to controls. Publication Status: Online-Only, [RefSeq, PubMed]; The cellular localization of phosphoglycerate mutase (PGAM1) type B in the endothelium of the capillaries and arteries of the brain, liver and kidneys was determined by immunocytochemistry., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P0K6", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0004082 bisphosphoglycerate mutase activity;GO:0004619 phosphoglycerate mutase activity;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:1990917 ooplasm", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0061621 canonical glycolysis;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P25113-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28064-1", "uniprot_id": [ { "id": "PSB8_RAT", "url": "https://www.uniprot.org/uniprot/P28064", "type": "external" } ], "mass": 30570.0, "length": 276, "protein_name": "Proteasome subunit beta type-8", "gene_name": "Psmb8", "organism": "Rat", "refseq_name": "proteasome subunit beta type-8", "refseq_ac": [ { "id": "NP_542945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542945", "type": "external" } ], "gene_names_uniprotkb": "Psmb8", "gene_names_refseq": "Lmp7; Psmb8; Ring10", "protein_names_uniprotkb": "Proteasome subunit beta type-8; 3.4.25.1; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; Proteasome component C13; Proteasome subunit beta-5i", "protein_names_refseq": "large multifunctional protease 7; low molecular mass polypeptide 7; macropain subunit C13; multicatalytic endopeptidase complex subunit C13; proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8; proteasome component C13; proteasome subunit beta 8; proteasome subunit beta type-8-like; proteasome subunit beta type-8; proteasome subunit beta-5i", "tax_id": 10116, "disease": "proteasome-associated autoinflammatory syndrome 1 (Disease Ontology:DOID:0050553)", "pathway": " (rno:24968); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-9907900); (R-RNO-9912633)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "1451788;15060004;16769238;16988215;29393594;32255680", "class_list": "", "function": "Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; LMP7 immuno-subunit is induced in renal cells exposed to a long-lasting renal ischemia and inflammation., [RefSeq, PubMed]; The inducible beta5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient beta-cells and is overexpressed in type 2 diabetes pancreatic islets., [RefSeq, PubMed]; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May participate in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity). Required for adipocyte differentiation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6MGA4", "ec_number_list": [ { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:1990111 spermatoproteasome complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045444 fat cell differentiation;GO:0019882 antigen processing and presentation;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P28064-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28073-1", "uniprot_id": [ { "id": "PSB6_RAT", "url": "https://www.uniprot.org/uniprot/P28073", "type": "external" } ], "mass": 25290.0, "length": 238, "protein_name": "Proteasome subunit beta type-6", "gene_name": "Psmb6", "organism": "Rat", "refseq_name": "proteasome subunit beta type-6", "refseq_ac": [ { "id": "NP_476440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476440", "type": "external" } ], "gene_names_uniprotkb": "Psmb6; Psmb6l", "gene_names_refseq": "Psmb6l; Psmb6", "protein_names_uniprotkb": "Proteasome subunit beta type-6; 3.4.25.1; Macropain delta chain; Multicatalytic endopeptidase complex delta chain; Proteasome chain 5; Proteasome delta chain; Proteasome subunit Y; Proteasome subunit beta-1; beta-1", "protein_names_refseq": "beta-1; macropain delta chain; multicatalytic endopeptidase complex delta chain; proteasome (prosome, macropain) subunit, beta type 6; proteasome beta 6 subunit; proteasome chain 5; proteasome delta chain; proteasome subunit Y; proteasome subunit beta 6; proteasome subunit beta type-6; proteasome subunit beta-1", "tax_id": 10116, "disease": "", "pathway": " (rno:100360846); (rno:29666); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 59, "publication_count": 4, "publication_id_list": "1491007;15060002;2335214;23844134", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues., [UniProtKB, UniProtKB]; The present study revealed for the first time that one of the proteasome subunits, PSMB6, was increased in the distal PA from a CHPH rat model. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IE68;Q6PDW5", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "4.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.17", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P28073-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28077-1", "uniprot_id": [ { "id": "PSB9_RAT", "url": "https://www.uniprot.org/uniprot/P28077", "type": "external" } ], "mass": 23324.0, "length": 219, "protein_name": "Proteasome subunit beta type-9", "gene_name": "Psmb9", "organism": "Rat", "refseq_name": "proteasome subunit beta type-9", "refseq_ac": [ { "id": "NP_036840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036840", "type": "external" } ], "gene_names_uniprotkb": "Psmb9; Lmp2; Ring12", "gene_names_refseq": "Lmp2; Psmb9", "protein_names_uniprotkb": "Proteasome subunit beta type-9; 3.4.25.1; Low molecular mass protein 2; Macropain chain 7; Multicatalytic endopeptidase complex chain 7; Proteasome chain 7; Proteasome subunit beta-1i; Really interesting new gene 12 protein", "protein_names_refseq": "RING12 protein; large multifunctional protease 2; low molecular mass polypeptide 2; low molecular mass protein 2; macropain chain 7; multicatalytic endopeptidase complex chain 7; proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2); proteasome (prosome, macropain) subunit, beta type, 9; proteasome chain 7; proteasome subunit beta 9; proteasome subunit beta type-9; proteasome subunit beta-1i; proteosome (prosome, macropain) subunit, beta type 9; really interesting new gene 12 protein", "tax_id": 10116, "disease": "lymphoma (Disease Ontology:DOID:0060058); colorectal carcinoma (Disease Ontology:DOID:0080199); adult respiratory distress syndrome (Disease Ontology:DOID:11394); vitiligo (Disease Ontology:DOID:12306); Huntington's disease (Disease Ontology:DOID:12858); peptic esophagitis (Disease Ontology:DOID:13976); multiple sclerosis (Disease Ontology:DOID:2377); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal cell carcinoma (Disease Ontology:DOID:4450); ankylosing spondylitis (Disease Ontology:DOID:7147); autoimmune thyroiditis (Disease Ontology:DOID:7188); oncocytic carcinoma of the thyroid (Disease Ontology:DOID:8161); psoriasis (Disease Ontology:DOID:8893)", "pathway": " (rno:24967); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-9907900); (R-RNO-9912633)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "1491007;16988215;2335214;29393594;34857032;36978132", "class_list": "", "function": "Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood-brain barrier injury through the Wnt/beta-catenin signalling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions. Publication Status: Online-Only, [RefSeq, PubMed]; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0070628 proteasome binding;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:1990111 spermatoproteasome complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0043279 response to alkaloid;GO:0001889 liver development;GO:0009617 response to bacterium;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048536 spleen development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P28077-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28572-2", "uniprot_id": [ { "id": "SC6A9_RAT", "url": "https://www.uniprot.org/uniprot/P28572", "type": "external" } ], "mass": 71061.0, "length": 638, "protein_name": "Sodium- and chloride-dependent glycine transporter 1", "gene_name": "Slc6a9", "organism": "Rat", "refseq_name": "sodium- and chloride-dependent glycine transporter 1", "refseq_ac": [ { "id": "NP_446270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446270", "type": "external" } ], "gene_names_uniprotkb": "Slc6a9", "gene_names_refseq": "GLYT-1b; GLYT-1; Glyt1; Slc6a9", "protein_names_uniprotkb": "Sodium- and chloride-dependent glycine transporter 1; GlyT-1; GlyT1; Solute carrier family 6 member 9", "protein_names_refseq": "glycine transporter 1; sodium- and chloride-dependent glycine transporter 1; solute carrier family 6 (neurotransmitter transporter, glycine), member 9", "tax_id": 10116, "disease": "idiopathic scoliosis (Disease Ontology:DOID:0060250); glycine encephalopathy (Disease Ontology:DOID:9268)", "pathway": " (rno:116509); (R-RNO-442660)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "1353889;1534013;16181645;22673903;24036061;25057202;26200505;26302655;33484385;38843836;8494645;9786914", "class_list": "", "function": "Double labeling for GLYT1 and synaptophysin of this vesicular fraction revealed that more of ninety percent of them were synaptic vesicles, [RefSeq, PubMed]; Inhibition of GlyT1 reduces the frequency of spontaneous network events in the hippocampus., [RefSeq, PubMed]; Regulation of the Glycine Transporter GLYT1 by microRNAs., [RefSeq, PubMed]; Sodium- and chloride-dependent glycine transporter (PubMed:1534013, PubMed:16181645). Essential for regulating glycine concentrations at inhibitory glycinergic synapses (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Study demonstrated a biphasic response of GlyT1 expression during epileptogenesis with initial downregulation of GlyT1 after epileptogenesis-precipitating seizures followed by sustained pathological overexpression of GlyT1 in chronic epilepsy, [RefSeq, PubMed]; Study showed that glycine uptake mediated by GlyT1 and GlyT2 in astrocytes is modulated by BDNF, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A1A5N0;Q63322;Q63323", "ec_number_list": [], "go_molecular_function": "GO:0015187 glycine transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity;GO:0015375 glycine:sodium symporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0016323 basolateral plasma membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0046985 positive regulation of hemoglobin biosynthetic process;GO:0035725 sodium ion transmembrane transport;GO:0001504 neurotransmitter uptake;GO:0061537 glycine secretion, neurotransmission", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P28572-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29117-1", "uniprot_id": [ { "id": "PPIF_RAT", "url": "https://www.uniprot.org/uniprot/P29117", "type": "external" } ], "mass": 21810.0, "length": 206, "protein_name": "Peptidyl-prolyl cis-trans isomerase F, mitochondrial", "gene_name": "Ppif", "organism": "Rat", "refseq_name": "peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor", "refseq_ac": [ { "id": "NP_758443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758443", "type": "external" } ], "gene_names_uniprotkb": "Ppif", "gene_names_refseq": "CyP-D; CypD; PPIase; Ppif", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase F, mitochondrial; 5.2.1.8; CyP-D; Cyclophilin D; Cyclophilin F; CypD; PPIase F; Rotamase F", "protein_names_refseq": "PPIase F; cyclophilin D; cyclophilin F; peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor; peptidyl-prolyl cis-trans isomerase F, mitochondrial; rotamase F", "tax_id": 10116, "disease": "", "pathway": " (rno:282819)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1599421;18667415;19228691;26975474;27864141;8567677;9309684;9820802;9874241", "class_list": "", "function": "Cyclophilin D may modify mitochondrial features by inducing the translocation of molecules to the mitochondria through the mechanism associated with cellular energy metabolism, [RefSeq, PubMed]; Data show that the redox state of cyclophilin D was stimulated by thioredoxin 1 and 2 and peroxiredoxin 3 in heart mitochondria. Publication Status: Online-Only, [RefSeq, PubMed]; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (By similarity). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:8567677, PubMed:9309684, PubMed:9820802). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:8567677, PubMed:9309684, PubMed:9820802). In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:8567677, PubMed:9309684, PubMed:9820802). Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (PubMed:8567677, PubMed:9309684, PubMed:9820802). Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0042277 peptide binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005757 mitochondrial permeability transition pore complex", "go_biological_process": "GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death;GO:0002931 response to ischemia;GO:0006979 response to oxidative stress;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P29117-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29524-1", "uniprot_id": [ { "id": "PAI2_RAT", "url": "https://www.uniprot.org/uniprot/P29524", "type": "external" } ], "mass": 47248.0, "length": 416, "protein_name": "Plasminogen activator inhibitor 2 type A", "gene_name": "Serpinb2", "organism": "Rat", "refseq_name": "plasminogen activator inhibitor 2 type A", "refseq_ac": [ { "id": "NP_067728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067728", "type": "external" } ], "gene_names_uniprotkb": "Serpinb2; Pai2; Planh2", "gene_names_refseq": "Pai2a; Serpinb2", "protein_names_uniprotkb": "Plasminogen activator inhibitor 2 type A; PAI-2; PAI2A; Serpin B2", "protein_names_refseq": "PAI-2; plasminogen activator inhibitor 2 type A; serine (or cysteine) peptidase inhibitor, clade B, member 2; serine (or cysteine) proteinase inhibitor, clade B, member 2; serpin B2; serpin peptidase inhibitor, clade B (ovalbumin), member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:60325); (R-RNO-75205)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits urokinase-type plasminogen activator., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0001533 cornified envelope", "go_biological_process": "GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P29524-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30120-1", "uniprot_id": [ { "id": "TIMP1_RAT", "url": "https://www.uniprot.org/uniprot/P30120", "type": "external" } ], "mass": 23794.0, "length": 217, "protein_name": "Metalloproteinase inhibitor 1", "gene_name": "Timp1", "organism": "Rat", "refseq_name": "metalloproteinase inhibitor 1 precursor", "refseq_ac": [ { "id": "NP_446271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446271", "type": "external" } ], "gene_names_uniprotkb": "Timp1; Timp-1", "gene_names_refseq": "TIMP-1; Timp1; Timp", "protein_names_uniprotkb": "Metalloproteinase inhibitor 1; TIMP-1; Tissue inhibitor of metalloproteinases 1", "protein_names_refseq": "metalloproteinase inhibitor 1 precursor; metalloproteinase inhibitor 1; tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); congenital anomalies of the kidney and urinary tract 2 (Disease Ontology:DOID:0080207); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); adrenoleukodystrophy (Disease Ontology:DOID:10588); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); intracranial aneurysm (Disease Ontology:DOID:10941); heart disease (Disease Ontology:DOID:114); Kawasaki disease (Disease Ontology:DOID:13378); cholestasis (Disease Ontology:DOID:13580); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Down syndrome (Disease Ontology:DOID:14250); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); vascular disease (Disease Ontology:DOID:178); preretinal fibrosis (Disease Ontology:DOID:2006); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); degenerative disc disease (Disease Ontology:DOID:90); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:116510); (R-RNO-114608); (R-RNO-1592389); (R-RNO-381426); (R-RNO-8957275); (R-RNO-9839383)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "1309971;32570968;33355364;37700105;38499842;7777858;7926820;8707259", "class_list": "", "function": "Coexpression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemiareperfusion injury by promoting angiogenesis and inhibiting oxidative stress., [RefSeq, PubMed]; GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression. Publication Status: Online-Only, [RefSeq, PubMed]; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity., [UniProtKB, PubMed, PubMed]; Secretome Analysis of Mesenchymal Stem Cell Factors Fostering Oligodendroglial Differentiation of Neural Stem Cells In Vivo. Publication Status: Online-Only, [RefSeq, PubMed]; TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P70533;Q53YM7", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0008270 zinc ion binding;GO:0030414 peptidase inhibitor activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:1905049 negative regulation of metallopeptidase activity;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0043086 negative regulation of catalytic activity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P30120-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30835-1", "uniprot_id": [ { "id": "PFKAL_RAT", "url": "https://www.uniprot.org/uniprot/P30835", "type": "external" } ], "mass": 85339.0, "length": 780, "protein_name": "ATP-dependent 6-phosphofructokinase, liver type", "gene_name": "Pfkl", "organism": "Rat", "refseq_name": "ATP-dependent 6-phosphofructokinase, liver type", "refseq_ac": [ { "id": "NP_037322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037322", "type": "external" } ], "gene_names_uniprotkb": "Pfkl; Pfk-l", "gene_names_refseq": "ATP-PFK; PFK-L; Pfkl", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase, liver type; 2.7.1.11; 6-phosphofructokinase type B; ATP-PFK; PFK-B; PFK-L; Phosphofructo-1-kinase isozyme B; Phosphohexokinase", "protein_names_refseq": "6-phosphofructokinase type B; 6-phosphofructokinase, liver type; ATP-dependent 6-phosphofructokinase, liver type; PFK-B; phosphofructo-1-kinase isozyme B; phosphofructokinase 1; phosphofructokinase, liver, B-type; phosphohexokinase", "tax_id": 10116, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); glycogen storage disease (Disease Ontology:DOID:2747)", "pathway": " (rno:25741); (R-RNO-6798695); (R-RNO-70171)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1836995;22673903;38843836", "class_list": "", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity)., [UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0005945 6-phosphofructokinase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0046676 negative regulation of insulin secretion;GO:0009749 response to glucose;GO:0006096 glycolytic process;GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P30835-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31214-1", "uniprot_id": [ { "id": "S5A2_RAT", "url": "https://www.uniprot.org/uniprot/P31214", "type": "external" } ], "mass": 28772.0, "length": 254, "protein_name": "3-oxo-5-alpha-steroid 4-dehydrogenase 2", "gene_name": "Srd5a2", "organism": "Rat", "refseq_name": "3-oxo-5-alpha-steroid 4-dehydrogenase 2", "refseq_ac": [ { "id": "NP_073202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073202", "type": "external" } ], "gene_names_uniprotkb": "Srd5a2", "gene_names_refseq": "S5AR 2; Srd5a2", "protein_names_uniprotkb": "3-oxo-5-alpha-steroid 4-dehydrogenase 2; 1.3.1.22; 5 alpha-SR2; S5AR 2; SR type 2; Steroid 5-alpha-reductase 2", "protein_names_refseq": "3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; SR type 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); hypospadias (Disease Ontology:DOID:10892); hyperprolactinemia (Disease Ontology:DOID:12700); breast carcinoma (Disease Ontology:DOID:3459); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:64677); (R-RNO-193048)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1527072;22776423;23122426;23405234;27150077;27155079", "class_list": "", "function": "Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed:1527072). Converts testosterone into 5-alpha-dihydrotestosterone (DHT), the most active androgen in the prostate, as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual differentiation during development (PubMed:1527072). Besides testosterone, it can also act on other steroids, including progesterone, producing metabolites with diverse roles (PubMed:1527072). Hence, it plays a central role in sexual differentiation and androgen physiology (By similarity)., [UniProtKB, PubMed, UniProtKB]; Changes in the expression of steroid 5-alpha reductase isoenzymes in the prostate in response to environmental stress., [RefSeq, PubMed]; Findings show that, in the adult brain, 5alphaR2 is distributed in critical regions for behavioral regulation, suggesting that the functional role of this isoform is present throughout the entire lifespan of the individual, [RefSeq, PubMed]; Low Srd5a2 expression is associated with benign prostatic hypertrophy., [RefSeq, PubMed]; Results suggest that in the acute phase after spinal cord injury, the increased expression of 18kDa translocator protein and 5alpha-reductase may represent a protective endogenous response against tissue injury., [RefSeq, PubMed]; Taken together, DEHP-disturbed HPT axis and induced 5alpha-Reductase 2 contribute to the reduction of serum testosterone level. The activated ERK pathway is required to modulate expressions of 5alpha-Reductase 2 and SRB1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.22", "type": "external" }, { "id": "1.3.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94", "type": "external" } ], "go_molecular_function": "GO:0033218 amide binding;GO:0047045 testosterone dehydrogenase (NADP+) activity;GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane;GO:0070852 cell body fiber", "go_biological_process": "GO:0030540 female genitalia development;GO:0030154 cell differentiation;GO:0021766 hippocampus development;GO:0031667 response to nutrient levels;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P31214-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33580-1", "uniprot_id": [ { "id": "PR8A4_RAT", "url": "https://www.uniprot.org/uniprot/P33580", "type": "external" } ], "mass": 27407.0, "length": 239, "protein_name": "Prolactin-8A4", "gene_name": "Prl8a4", "organism": "Rat", "refseq_name": "prolactin-8A4 precursor", "refseq_ac": [ { "id": "NP_067591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067591", "type": "external" } ], "gene_names_uniprotkb": "Prl8a4; Prlph", "gene_names_refseq": "Prl8a4; Prlph", "protein_names_uniprotkb": "Prolactin-8A4; Growth hormone-related placental protein 3; PLP-H; PRL-like protein H; Placental prolactin-like protein H", "protein_names_refseq": "PLP-H; PRL-like protein H; growth hormone-related placental protein 3; placental prolactin-like protein H; prolactin-8A4 precursor; prolactin-8A4", "tax_id": 10116, "disease": "", "pathway": " (rno:59088)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2351117;9832436", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9R2D1", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P33580-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34978-1", "uniprot_id": [ { "id": "TA2R_RAT", "url": "https://www.uniprot.org/uniprot/P34978", "type": "external" } ], "mass": 36928.0, "length": 341, "protein_name": "Thromboxane A2 receptor", "gene_name": "Tbxa2r", "organism": "Rat", "refseq_name": "thromboxane A2 receptor", "refseq_ac": [ { "id": "NP_058750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058750", "type": "external" } ], "gene_names_uniprotkb": "Tbxa2r", "gene_names_refseq": "Tbxa2r", "protein_names_uniprotkb": "Thromboxane A2 receptor; Prostanoid TP receptor; TXA2-R; TXR2", "protein_names_refseq": "TXA2-R; TXR2; Thromboxane receptor; prostanoid TP receptor; thromboxane A2 receptor", "tax_id": 10116, "disease": "aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); kidney failure (Disease Ontology:DOID:1074); adult respiratory distress syndrome (Disease Ontology:DOID:11394); toxic shock syndrome (Disease Ontology:DOID:14115); thrombocytopenia (Disease Ontology:DOID:1588); blood platelet disease (Disease Ontology:DOID:2218); asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:24816); (R-RNO-391908); (R-RNO-416476); (R-RNO-416482); (R-RNO-428930)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "25857252;26708952;27178425;32530751;7635958;7696353;8936585", "class_list": "", "function": "Data suggest that thromboxane A2/Tbxa2r-mediated vasoconstriction of intracavernous small penile arteries depends on Ca2+ influx through L-type calcium channels and TRP (transient receptor potential) channels, and ROCK- (Rho kinase)-dependent mechanisms in vascular smooth muscle., [RefSeq, PubMed]; Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase., [UniProtKB]; The experiments suggest that in the SHR but not the WKY aorta, alpha1 -adrenoceptor activation desensitizes TP receptors through activation of PKC-epsilon., [RefSeq, PubMed]; The long-lasting oligemia following cortical spreading depression consists of at least two distinct temporal phases, mediated by preferential actions of COX-1- and COX-2-derived prostanoids: an initial phase mediated by COX-1 that involves TXA2 followed by a later phase, mediated by COX-2 and PGF2alpha., [RefSeq, PubMed]; Thromboxane A2 receptors mediate chronic mechanoreflex sensitization in a rat model of simulated peripheral artery disease., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004961 thromboxane A2 receptor activity;GO:0004960 thromboxane receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P34978-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35355-1", "uniprot_id": [ { "id": "PGH2_RAT", "url": "https://www.uniprot.org/uniprot/P35355", "type": "external" } ], "mass": 69164.0, "length": 604, "protein_name": "Prostaglandin G/H synthase 2", "gene_name": "Ptgs2", "organism": "Rat", "refseq_name": "prostaglandin G/H synthase 2 precursor", "refseq_ac": [ { "id": "NP_058928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058928", "type": "external" } ], "gene_names_uniprotkb": "Ptgs2; Cox-2; Cox2", "gene_names_refseq": "COX-2; Cox2; PGHS-2; PHS II; Pghs2; Ptgs2", "protein_names_uniprotkb": "Prostaglandin G/H synthase 2; 1.14.99.1; COX-2; Cyclooxygenase-2; PGH synthase 2; PGHS-2; PHS II; Prostaglandin H2 synthase 2; Prostaglandin-endoperoxide synthase 2", "protein_names_refseq": "PGH synthase 2; cyclooxygenase-2; prostaglandin G/H synthase 2 precursor; prostaglandin G/H synthase 2; prostaglandin H2 synthase 2", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); obstructive sleep apnea (Disease Ontology:DOID:0050848); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); colitis (Disease Ontology:DOID:0060180); polycystic kidney disease (Disease Ontology:DOID:0080322); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Parkinsonism (Disease Ontology:DOID:0080855); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); meconium aspiration syndrome (Disease Ontology:DOID:11049); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); sarcoidosis (Disease Ontology:DOID:11335); nephrotic syndrome (Disease Ontology:DOID:1184); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); esophagitis (Disease Ontology:DOID:11963); secondary hyperparathyroidism (Disease Ontology:DOID:12466); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); lung cancer (Disease Ontology:DOID:1324); prostatitis (Disease Ontology:DOID:14654); cystic fibrosis (Disease Ontology:DOID:1485); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); Wernicke encephalopathy (Disease Ontology:DOID:2384); transitional cell carcinoma (Disease Ontology:DOID:2671); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); adenocarcinoma (Disease Ontology:DOID:299); granulosa cell tumor (Disease Ontology:DOID:2999); acute kidney failure (Disease Ontology:DOID:3021); glioblastoma (Disease Ontology:DOID:3068); gliosarcoma (Disease Ontology:DOID:3071); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); demyelinating disease (Disease Ontology:DOID:3213); bipolar disorder (Disease Ontology:DOID:3312); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastritis (Disease Ontology:DOID:4029); systemic scleroderma (Disease Ontology:DOID:418); renal cell carcinoma (Disease Ontology:DOID:4450); avian influenza (Disease Ontology:DOID:4492); retrograde amnesia (Disease Ontology:DOID:4543); esophagus adenocarcinoma (Disease Ontology:DOID:4914); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); prolactinoma (Disease Ontology:DOID:5394); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); intestinal obstruction (Disease Ontology:DOID:8437); ulcerative colitis (Disease Ontology:DOID:8577); prostate carcinoma in situ (Disease Ontology:DOID:8634); in situ carcinoma (Disease Ontology:DOID:8719); Crohn's disease (Disease Ontology:DOID:8778); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); Barrett's esophagus (Disease Ontology:DOID:9206); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); pulmonary emphysema (Disease Ontology:DOID:9675); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:29527); (R-RNO-2142770); (R-RNO-2162123); (R-RNO-9018677); (R-RNO-9018679); (R-RNO-9025094); (R-RNO-9027604)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "10816563;10966456;1556140;24605250;36586043;36768450;37059378;37562566;38286397;7916614;8203528;8274023;8352945", "class_list": "", "function": "COX2 expression plays a role in spinal cord injury-induced neuropathic pain., [RefSeq, PubMed]; Combination of Radix Astragali and Safflower Promotes Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2. Publication Status: Online-Only, [RefSeq, PubMed]; Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia., [RefSeq, PubMed]; Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S-RvE2. In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection. In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11-diHETE). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Electroacupuncture regulates microglial polarization via inhibiting NF-kappaB/COX2 pathway following traumatic brain injury., [RefSeq, PubMed]; Mineralocorticoid receptors contribute to ethanol-induced vascular hypercontractility through reactive oxygen species generation and up-regulation of cyclooxygenase 2., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 76, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q64379;Q925V4", "ec_number_list": [ { "id": "1.14.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.1", "type": "external" }, { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" }, { "id": "5.3.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.4", "type": "external" } ], "go_molecular_function": "GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0004666 prostaglandin-endoperoxide synthase activity;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0001525 angiogenesis;GO:0006979 response to oxidative stress;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P35355-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35433-1", "uniprot_id": [ { "id": "PUR1_RAT", "url": "https://www.uniprot.org/uniprot/P35433", "type": "external" } ], "mass": 57437.0, "length": 517, "protein_name": "Amidophosphoribosyltransferase", "gene_name": "Ppat", "organism": "Rat", "refseq_name": "amidophosphoribosyltransferase", "refseq_ac": [ { "id": "NP_476546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476546", "type": "external" } ], "gene_names_uniprotkb": "Ppat", "gene_names_refseq": "Atase; Ppat", "protein_names_uniprotkb": "Amidophosphoribosyltransferase; 2.4.2.14; ATase; GPAT; Glutamine phosphoribosylpyrophosphate amidotransferase", "protein_names_refseq": "GPAT; amidophosphoribosyltransferase; glutamine phosphoribosylpyrophosphate amidotransferase", "tax_id": 10116, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:117544); (R-RNO-73817)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "29393594;7742366;8463258", "class_list": "", "function": "Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.14", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0004044 amidophosphoribosyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0001822 kidney development;GO:0071466 cellular response to xenobiotic stimulus;GO:0060135 maternal process involved in female pregnancy;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P35433-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37377-1", "uniprot_id": [ { "id": "SYUA_RAT", "url": "https://www.uniprot.org/uniprot/P37377", "type": "external" } ], "mass": 14515.0, "length": 140, "protein_name": "Alpha-synuclein", "gene_name": "Snca", "organism": "Rat", "refseq_name": "alpha-synuclein", "refseq_ac": [ { "id": "NP_062042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062042", "type": "external" } ], "gene_names_uniprotkb": "Snca", "gene_names_refseq": "Snca", "protein_names_uniprotkb": "Alpha-synuclein", "protein_names_refseq": "alpha-synuclein; synuclein, alpha (non A4 component of amyloid precursor)", "tax_id": 10116, "disease": "Parkinson's disease 1 (Disease Ontology:DOID:0060367); Parkinson's disease 4 (Disease Ontology:DOID:0060895); Alzheimer's disease (Disease Ontology:DOID:10652); Pick's disease (Disease Ontology:DOID:11870); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330); depressive disorder (Disease Ontology:DOID:1596); neurilemmoma (Disease Ontology:DOID:3192); bipolar disorder (Disease Ontology:DOID:3312); pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981); multiple system atrophy (Disease Ontology:DOID:4752); schizophrenia (Disease Ontology:DOID:5419); amphetamine abuse (Disease Ontology:DOID:670); myeloid leukemia (Disease Ontology:DOID:8692); vascular dementia (Disease Ontology:DOID:8725)", "pathway": " (rno:29219); (R-RNO-9833482)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10582622;12408865;12665621;1661825;17101231;19692427;21050448;22673903;24810576;29180624;29563864;30155513;31758091;3411354;35279896;37487948;37542299;37890776;38151185;38581539", "class_list": "", "function": "Differential expression of alpha-synuclein in the hippocampus of SHR and SLA16 isogenic rat strains., [RefSeq, PubMed]; Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by alpha-Synuclein., [RefSeq, PubMed]; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity)., [UniProtKB, UniProtKB]; The toxicities of A30P and A53T alpha-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine., [RefSeq, PubMed]; Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer., [RefSeq, PubMed]; VPS35 and alpha-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P37378;Q53YM9", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003779 actin binding;GO:0004857 enzyme inhibitor activity;GO:0005543 phospholipid binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006638 neutral lipid metabolic process;GO:0014048 regulation of glutamate secretion;GO:0050812 regulation of acyl-CoA biosynthetic process;GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission;GO:0051622 negative regulation of norepinephrine uptake", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P37377-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40307-1", "uniprot_id": [ { "id": "PSB2_RAT", "url": "https://www.uniprot.org/uniprot/P40307", "type": "external" } ], "mass": 22912.0, "length": 201, "protein_name": "Proteasome subunit beta type-2", "gene_name": "Psmb2", "organism": "Rat", "refseq_name": "proteasome subunit beta type-2", "refseq_ac": [ { "id": "NP_058980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058980", "type": "external" } ], "gene_names_uniprotkb": "Psmb2", "gene_names_refseq": "Psmb2", "protein_names_uniprotkb": "Proteasome subunit beta type-2; Macropain subunit C7-I; Multicatalytic endopeptidase complex subunit C7-I; Proteasome component C7-I; Proteasome subunit beta-4; beta-4", "protein_names_refseq": "beta-4; macropain subunit C7-I; multicatalytic endopeptidase complex subunit C7-I; proteasome (prosome, macropain) subunit, beta type 2; proteasome beta 2 subunit; proteasome component C7-I; proteasome subunit beta 2; proteasome subunit beta type-2; proteasome subunit beta-4", "tax_id": 10116, "disease": "", "pathway": " (rno:29675); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 57, "publication_count": 2, "publication_id_list": "16988215;8405448", "class_list": "", "function": "Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P40307-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40329-1", "uniprot_id": [ { "id": "SYRC_RAT", "url": "https://www.uniprot.org/uniprot/P40329", "type": "external" } ], "mass": 75810.0, "length": 660, "protein_name": "Arginine--tRNA ligase, cytoplasmic", "gene_name": "Rars1", "organism": "Rat", "refseq_name": "arginine--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_001099247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099247", "type": "external" } ], "gene_names_uniprotkb": "Rars1; Rars", "gene_names_refseq": "Rars1; Rars", "protein_names_uniprotkb": "Arginine--tRNA ligase, cytoplasmic; 6.1.1.19; ArgRS; Arginyl-tRNA synthetase", "protein_names_refseq": "argRS; arginine--tRNA ligase, cytoplasmic; arginyl-tRNA synthetase, cytoplasmic", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy 9 (Disease Ontology:DOID:0060791)", "pathway": " (rno:287191); (R-RNO-9856649)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "2187187;24710927;25467976", "class_list": "", "function": "Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1., [UniProtKB, UniProtKB]; The expression levels of ArgRS mRNA and protein in ischemic penumbra varied with ischemic time, suggesting that the energy metabolism of brain cells in penumbra changed dynamically after ischemia to ensure the endogenous self-protection of the body, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1WBX8", "ec_number_list": [ { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004814 arginine-tRNA ligase activity;GO:0034618 arginine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex", "go_biological_process": "GO:0006420 arginyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P40329-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41498-1", "uniprot_id": [ { "id": "PPAC_RAT", "url": "https://www.uniprot.org/uniprot/P41498", "type": "external" } ], "mass": 18152.0, "length": 158, "protein_name": "Low molecular weight phosphotyrosine protein phosphatase", "gene_name": "Acp1", "organism": "Rat", "refseq_name": "low molecular weight phosphotyrosine protein phosphatase isoform A", "refseq_ac": [ { "id": "NP_067085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067085", "type": "external" } ], "gene_names_uniprotkb": "Acp1", "gene_names_refseq": "Acp1", "protein_names_uniprotkb": "Low molecular weight phosphotyrosine protein phosphatase; 3.1.3.2; 3.1.3.48; LMW-PTPase; LMW-PTP; Low molecular weight cytosolic acid phosphatase", "protein_names_refseq": "LMW-PTP-I low molecular weight phosphotyrosine protein phosphatase isozyme 1; LMW-PTPase; acid phosphatase 1, soluble; low molecular weight cytosolic acid phosphatase; low molecular weight phosphotyrosine protein phosphatase isoform A", "tax_id": 10116, "disease": "leukodystrophy (Disease Ontology:DOID:10579); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); conduct disorder (Disease Ontology:DOID:12995); cystic fibrosis (Disease Ontology:DOID:1485); coronary artery disease (Disease Ontology:DOID:3393); myopathy (Disease Ontology:DOID:423); primary hyperaldosteronism (Disease Ontology:DOID:446); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24161)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11971983;1388675;16893901;29393594", "class_list": "", "function": "Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; GRX plays an important role in PDGF-BB-dependent cell proliferation by regulating the redox state of LMW-PTP, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9R138", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0003993 acid phosphatase activity;GO:0016791 phosphatase activity;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0042383 sarcolemma;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P41498-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42533-1", "uniprot_id": [ { "id": "TF_RAT", "url": "https://www.uniprot.org/uniprot/P42533", "type": "external" } ], "mass": 33444.0, "length": 295, "protein_name": "Tissue factor", "gene_name": "F3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "F3; Cf3", "gene_names_refseq": "", "protein_names_uniprotkb": "Tissue factor; Coagulation factor III; TF", "protein_names_refseq": "", "tax_id": 10116, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); thrombosis (Disease Ontology:DOID:0060903); myeloid neoplasm (Disease Ontology:DOID:0070004); COVID-19 (Disease Ontology:DOID:0080600); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); preterm premature rupture of the membranes (Disease Ontology:DOID:0111144); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); von Willebrand's disease (Disease Ontology:DOID:12531); acute pancreatitis (Disease Ontology:DOID:2913); carotid artery thrombosis (Disease Ontology:DOID:3410); bile duct disease (Disease Ontology:DOID:4138); liver cirrhosis (Disease Ontology:DOID:5082); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25584); (R-RNO-9769735); (R-RNO-9769739)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8950776", "class_list": "", "function": "Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 27, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005543 phospholipid binding;GO:0004896 cytokine receptor activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0010628 positive regulation of gene expression;GO:0016485 protein processing;GO:0032496 response to lipopolysaccharide;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P42533-1", "record_type": "protein", "filter_code": "0000000.1000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42667-1", "uniprot_id": [ { "id": "SC11A_RAT", "url": "https://www.uniprot.org/uniprot/P42667", "type": "external" } ], "mass": 20599.0, "length": 179, "protein_name": "Signal peptidase complex catalytic subunit SEC11A", "gene_name": "Sec11a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sec11a; Sec11l1; Spc18", "gene_names_refseq": "", "protein_names_uniprotkb": "Signal peptidase complex catalytic subunit SEC11A; 3.4.21.89; Endopeptidase SP18; Microsomal signal peptidase 18 kDa subunit; SEC11 homolog A; SEC11-like protein 1; SPC18; SPase 18 kDa subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-422085); (R-RNO-9768727)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7854339", "class_list": "", "function": "Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.89", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0009003 signal peptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex", "go_biological_process": "GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P42667-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42854-1", "uniprot_id": [ { "id": "REG3G_RAT", "url": "https://www.uniprot.org/uniprot/P42854", "type": "external" } ], "mass": 19144.0, "length": 174, "protein_name": "Regenerating islet-derived protein 3-gamma", "gene_name": "Reg3g", "organism": "Rat", "refseq_name": "regenerating islet-derived protein 3-gamma precursor", "refseq_ac": [ { "id": "NP_775120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775120", "type": "external" } ], "gene_names_uniprotkb": "Reg3g; Pap3", "gene_names_refseq": "PAPIII; Pap3; Reg3g", "protein_names_uniprotkb": "Regenerating islet-derived protein 3-gamma; Pancreatitis-associated protein 3; REG-3-gamma; Reg III-gamma; Regenerating islet-derived protein III-gamma", "protein_names_refseq": "REG-3-gamma; pancreatitis-associated protein 3; reg III-gamma; regenerating islet-derived 3 gamma; regenerating islet-derived protein 3-gamma precursor; regenerating islet-derived protein 3-gamma; regenerating islet-derived protein III-gamma", "tax_id": 10116, "disease": "", "pathway": " (rno:24620); (R-RNO-6803157)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15100001;16837594;23303201;23426365;23588857;31404030;7717998;8241280", "class_list": "", "function": "Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation. Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents. Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia., [UniProtKB, UniProtKB]; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota., [UniProtKB, UniProtKB]; Findings indicate that regenerating islet-derived 3 gamma (Reg3gamma) staining quantified through image analysis showed a time- and dose-response in cerulein-treated mice and rats., [RefSeq, PubMed]; Findings suggest that islet neogenesis-associated protein (INGAP) exerts a positive modulatory effect on beta-cell mass and its secretory function in fetal and neonatal rats, thus becoming a new component in the multifactorial regulation of such processes., [RefSeq, PubMed]; Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus., [UniProtKB, UniProtKB]; Has bacteriostatic activity., [UniProtKB, UniProtKB]; Released PAP-III might be cleaved and forms DeltaN-PAP-III fibers at the nerve injury sites. Consequently, these resulting fibers would provide regenerating axons with a platform for extension., [RefSeq, PubMed]; Results demonstrate that PAP-III is a novel macrophage chemoattractant that is involved in peripheral nerve regeneration, [RefSeq, PubMed]; The Reg3G gene plays a major role in communication between injured axons and muscle and may play a significant role in skeletal muscle and peripheral nerve regeneration., [RefSeq, PubMed]; There is a tight spatial and temporal association between pre-inflammatory changes or inflammation and PAP-expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0042834 peptidoglycan binding;GO:0046872 metal ion binding;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0009609 response to symbiotic bacterium;GO:0045617 negative regulation of keratinocyte differentiation;GO:0008284 positive regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P42854-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45352-1", "uniprot_id": [ { "id": "TYSY_RAT", "url": "https://www.uniprot.org/uniprot/P45352", "type": "external" } ], "mass": 35017.0, "length": 307, "protein_name": "Thymidylate synthase", "gene_name": "Tyms", "organism": "Rat", "refseq_name": "thymidylate synthase", "refseq_ac": [ { "id": "NP_062052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062052", "type": "external" } ], "gene_names_uniprotkb": "Tyms", "gene_names_refseq": "Tyms", "protein_names_uniprotkb": "Thymidylate synthase; 2.1.1.45; TSase; TS", "protein_names_refseq": "TSase; TS; thymidylate synthase", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); digenic dyskeratosis congenita (Disease Ontology:DOID:0060984); urinary bladder cancer (Disease Ontology:DOID:11054); colon carcinoma (Disease Ontology:DOID:1520); cancer (Disease Ontology:DOID:162); cerebral infarction (Disease Ontology:DOID:3526); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:29261); (R-RNO-499943)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "7711067;9894005", "class_list": "", "function": "Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant (Probable). Contributes to the mitochondrial and nuclear de novo thymidylate biosynthesis pathway (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN23", "ec_number_list": [ { "id": "2.1.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.45", "type": "external" } ], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:1990825 sequence-specific mRNA binding;GO:0004799 thymidylate synthase activity;GO:0003729 mRNA binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0060574 intestinal epithelial cell maturation;GO:0006231 dTMP biosynthetic process;GO:0019860 uracil metabolic process;GO:0006417 regulation of translation;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P45352-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46002-1", "uniprot_id": [ { "id": "PTAFR_RAT", "url": "https://www.uniprot.org/uniprot/P46002", "type": "external" } ], "mass": 39204.0, "length": 341, "protein_name": "Platelet-activating factor receptor", "gene_name": "Ptafr", "organism": "Rat", "refseq_name": "platelet-activating factor receptor", "refseq_ac": [ { "id": "NP_445773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445773", "type": "external" } ], "gene_names_uniprotkb": "Ptafr", "gene_names_refseq": "PAF-R; PAFr; Ptafr", "protein_names_uniprotkb": "Platelet-activating factor receptor; PAF-R; PAFr", "protein_names_refseq": "platelet-activating factor receptor", "tax_id": 10116, "disease": "pleurisy (Disease Ontology:DOID:10247); sciatic neuropathy (Disease Ontology:DOID:11446); neutropenia (Disease Ontology:DOID:1227); transient cerebral ischemia (Disease Ontology:DOID:224); glomerulonephritis (Disease Ontology:DOID:2921); acute kidney failure (Disease Ontology:DOID:3021); conjunctivitis (Disease Ontology:DOID:6195); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)", "pathway": " (rno:58949); (R-RNO-373076); (R-RNO-416476); (R-RNO-6798695)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "22296727;32329883;36682136;8168510", "class_list": "", "function": "MiR-30b-5p and miR-22-3p restrain the fibrogenesis of post-myocardial infarction in mice via targeting PTAFR., [RefSeq, PubMed]; Myocardial ischemia-reperfusion injury is probably due to the excessive production of mitochondrial ROS caused by the activation of 5-HT degradation system mediated by PAF receptor., [RefSeq, PubMed]; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system., [UniProtKB]; These data show the histological localization of PAF synthases and its receptor in the spinal cord following peripheral nerve injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0051019 mitogen-activated protein kinase binding;GO:0001530 lipopolysaccharide binding;GO:0045028 G protein-coupled purinergic nucleotide receptor activity;GO:0001875 lipopolysaccharide immune receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032959 inositol trisphosphate biosynthetic process;GO:1902943 positive regulation of voltage-gated chloride channel activity;GO:0009609 response to symbiotic bacterium;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P46002-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48032-1", "uniprot_id": [ { "id": "TIMP3_RAT", "url": "https://www.uniprot.org/uniprot/P48032", "type": "external" } ], "mass": 24226.0, "length": 211, "protein_name": "Metalloproteinase inhibitor 3", "gene_name": "Timp3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Timp3; Timp-3", "gene_names_refseq": "", "protein_names_uniprotkb": "Metalloproteinase inhibitor 3; TIMP-3; Tissue inhibitor of metalloproteinases 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "Sorsby's fundus dystrophy (Disease Ontology:DOID:0090114); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); sciatic neuropathy (Disease Ontology:DOID:11446); dilated cardiomyopathy (Disease Ontology:DOID:12930); thoracic aortic aneurysm (Disease Ontology:DOID:14004); breast cancer (Disease Ontology:DOID:1612); preretinal fibrosis (Disease Ontology:DOID:2006); breast carcinoma (Disease Ontology:DOID:3459); choriocarcinoma (Disease Ontology:DOID:3594); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25358); (R-RNO-114608)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8654952", "class_list": "", "function": "Mediates a variety of processes including matrix regulation and turnover, inflammation, and angiogenesis, through reversible inhibition of zinc protease superfamily enzymes, primarily matrix metalloproteinases (MMPs). Regulates extracellular matrix (ECM) remodeling through inhibition of matrix metalloproteinases (MMP) including MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Additionally, modulates the processing of amyloid precursor protein (APP) and apolipoprotein E receptor ApoER2 by inhibiting two alpha-secretases ADAM10 and ADAM17. Functions as a tumor suppressor and a potent inhibitor of angiogenesis. Exerts its anti-angiogenic effect by directly interacting with vascular endothelial growth factor (VEGF) receptor-2/KDR, preventing its binding to the VEGFA ligand. Selectively induces apoptosis in angiogenic endothelial cells through a caspase-independent cell death pathway. Mechanistically, inhibits matrix-induced focal adhesion kinase PTK2 tyrosine phosphorylation and association with paxillin/PXN and disrupts the incorporation of ITGB3, PTK2 and PXN into focal adhesion contacts on the matrix., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008191 metalloendopeptidase inhibitor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:1901706 mesenchymal cell differentiation involved in bone development;GO:0031667 response to nutrient levels;GO:0071456 cellular response to hypoxia;GO:0009612 response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P48032-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49445-1", "uniprot_id": [ { "id": "PTN7_RAT", "url": "https://www.uniprot.org/uniprot/P49445", "type": "external" } ], "mass": 40314.0, "length": 359, "protein_name": "Tyrosine-protein phosphatase non-receptor type 7", "gene_name": "Ptpn7", "organism": "Rat", "refseq_name": "tyrosine-protein phosphatase non-receptor type 7", "refseq_ac": [ { "id": "NP_663716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663716", "type": "external" } ], "gene_names_uniprotkb": "Ptpn7; Lcptp", "gene_names_refseq": "Heptp; Lcptp; Ptpn7", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 7; 3.1.3.48; HEPTP; Hematopoietic protein-tyrosine phosphatase; Protein-tyrosine phosphatase LC-PTP", "protein_names_refseq": "hematopoietic protein-tyrosine phosphatase; protein-tyrosine phosphatase LC-PTP; tyrosine-protein phosphatase non-receptor type 7", "tax_id": 10116, "disease": "", "pathway": " (rno:246781); (R-RNO-5675221)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "20157115;22673903;7545170", "class_list": "", "function": "May play a role in the regulation of T and B-lymphocyte development and signal transduction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P49445-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49743-1", "uniprot_id": [ { "id": "RXRB_RAT", "url": "https://www.uniprot.org/uniprot/P49743", "type": "external" } ], "mass": 49078.0, "length": 458, "protein_name": "Retinoic acid receptor RXR-beta", "gene_name": "Rxrb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rxrb; Nr2b2; Rcor-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoic acid receptor RXR-beta; Nuclear receptor coregulator 1; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-383280); (R-RNO-5362517); (R-RNO-9029569); (R-RNO-9623433)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "1662118;28267642", "class_list": "", "function": "Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003707 nuclear steroid receptor activity;GO:0044877 protein-containing complex binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P49743-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49800-1", "uniprot_id": [ { "id": "RGS5_RAT", "url": "https://www.uniprot.org/uniprot/P49800", "type": "external" } ], "mass": 21052.0, "length": 181, "protein_name": "Regulator of G protein signaling 5", "gene_name": "Rgs5", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 5", "refseq_ac": [ { "id": "NP_062214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062214", "type": "external" } ], "gene_names_uniprotkb": "Rgs5", "gene_names_refseq": "Rgs5", "protein_names_uniprotkb": "Regulator of G protein signaling 5; RGS5", "protein_names_refseq": "regulator of G-protein signaling 5", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825)", "pathway": " (rno:54294); (R-RNO-416476); (R-RNO-418594)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "12006602;17939118;17986358;18207159;24489801;25842189;29061726;29393594;8548815", "class_list": "", "function": "AT1R activation results in translocation of RGS5 toward the plasma membrane, limiting AT1R-mediated vasoconstriction through its role in Gq/11 protein-dependent signaling., [RefSeq, PubMed]; After 2 days of aortic banding-induced hypertrophy, thoracic aorta lost expression of Rgs5, it returned to normal at 1 week and increased many fold at 28 days, indicating that RGS expression and function correlate with vascular remodeling., [RefSeq, PubMed]; Changes in common to caveolin-1 expression and G protein signalling, through attenuation of Rgs2 and Rgs5, may contribute to hypertension through augmentation of vasoconstrictor pathways Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity)., [UniProtKB]; Rgs5 and Dlx1 represent novel molecular targets for the regulation of ductus arteriosus maturation and closure. Publication Status: Online-Only, [RefSeq, PubMed]; Rgs5 and Notch3 are expressed in pericytes of developing and injured teeth and have roles along with vascular-derived stem cells during pulp healing, [RefSeq, PubMed]; Role in regulating mitogen-activated protein kinase activation in rat vascular smooth muscle cells, [RefSeq, PubMed]; The enhancement of RGS5 activity by GPSM3 is maintained under these conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKD7", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P49800-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50115-1", "uniprot_id": [ { "id": "S10A8_RAT", "url": "https://www.uniprot.org/uniprot/P50115", "type": "external" } ], "mass": 10239.0, "length": 89, "protein_name": "Protein S100-A8", "gene_name": "S100a8", "organism": "Rat", "refseq_name": "protein S100-A8", "refseq_ac": [ { "id": "NP_446274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446274", "type": "external" } ], "gene_names_uniprotkb": "S100a8; Mrp8", "gene_names_refseq": "Mrp8; S100a8", "protein_names_uniprotkb": "Protein S100-A8; Calgranulin-A; MRP-8; Migration inhibitory factor-related protein 8; S100 calcium-binding protein A8; p8", "protein_names_refseq": "MRP-8; S100 calcium binding protein A8 (calgranulin A); calgranulin-A; migration inhibitory factor-related protein 8; p8; protein S100-A8", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); myocarditis (Disease Ontology:DOID:820)", "pathway": " (rno:116547); (R-RNO-5668599); (R-RNO-5686938); (R-RNO-6798695); (R-RNO-6799990)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "21487906;29393594;36634215;37219522;38697446;39111720;39390946;8343166;9570842", "class_list": "", "function": "Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury., [RefSeq, PubMed]; Identification of S100A8/A9 involved in thromboangiitis obliterans development using tandem mass tags-labeled quantitative proteomics analysis., [RefSeq, PubMed]; MiR-24 regulates obstructive pulmonary disease in rats via S100A8., [RefSeq, PubMed]; S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Also participates in regulatory T-cell differentiation together with CD69. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity (By similarity)., [UniProtKB, PubMed, UniProtKB]; Study on the involvement of microglial S100A8 in neuroinflammation and microglia activation during migraine attacks., [RefSeq, PubMed]; TRPA1 deficiency aggravates dilated cardiomyopathy by promoting S100A8 expression to induce M1 macrophage polarization in rats. Erratum:[FASEB J. 2023 Aug;37(8):e23065. doi: 10.1096/fj.202301205. PMID: 37477922], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045111 intermediate filament cytoskeleton", "go_biological_process": "GO:0010043 response to zinc ion;GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0032496 response to lipopolysaccharide;GO:0045087 innate immune response;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P50115-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50235-1", "uniprot_id": [ { "id": "ST2A2_RAT", "url": "https://www.uniprot.org/uniprot/P50235", "type": "external" } ], "mass": 33531.0, "length": 285, "protein_name": "Sulfotransferase 2A2", "gene_name": "Sult2a2", "organism": "Rat", "refseq_name": "sulfotransferase 2A2", "refseq_ac": [ { "id": "NP_001020302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020302", "type": "external" } ], "gene_names_uniprotkb": "Sult2a2", "gene_names_refseq": "DST; SMP-2; ST2A2; Sult2a2", "protein_names_uniprotkb": "Sulfotransferase 2A2; 2.8.2.2; Hydroxysteroid sulfotransferase; SMP-2; ST-60; ST2A2; ST; Senescence marker protein 2", "protein_names_refseq": "Androgen-repressible liver protein; Dehydroepiandrosterone sulfotransferase; Probable alcohol sulfotransferase; ST-60; ST; Senescence marker protein 2; alcohol sulfotransferase-like; alcohol sulfotransferase; hydroxysteroid sulfotransferase; sulfotransferase 2A2", "tax_id": 10116, "disease": "", "pathway": " (rno:361510); (R-RNO-156584); (R-RNO-9753281)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "2302387;3805009;8033273", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a potential wide variety of acceptor molecules bearing a hydroxyl group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O09038;P07631;Q04169", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.14", "type": "external" }, { "id": "2.8.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.2", "type": "external" }, { "id": "2.8.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.1", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0004027 alcohol sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0051923 sulfation;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P50235-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51146-1", "uniprot_id": [ { "id": "RAB4B_RAT", "url": "https://www.uniprot.org/uniprot/P51146", "type": "external" } ], "mass": 23629.0, "length": 213, "protein_name": "Ras-related protein Rab-4B", "gene_name": "Rab4b", "organism": "Rat", "refseq_name": "ras-related protein Rab-4B", "refseq_ac": [ { "id": "NP_059051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059051", "type": "external" } ], "gene_names_uniprotkb": "Rab4b", "gene_names_refseq": "Rab4b", "protein_names_uniprotkb": "Ras-related protein Rab-4B; 3.6.5.2", "protein_names_refseq": "ras-related GTP-binding protein 4b; ras-related protein Rab-4B", "tax_id": 10116, "disease": "", "pathway": " (rno:50866); (R-RNO-6798695); (R-RNO-8873719); (R-RNO-8875656)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14 (By similarity). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0055037 recycling endosome;GO:0031901 early endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0030100 regulation of endocytosis;GO:0016192 vesicle-mediated transport;GO:0034058 endosomal vesicle fusion;GO:0032482 Rab protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P51146-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51158-1", "uniprot_id": [ { "id": "RAB28_RAT", "url": "https://www.uniprot.org/uniprot/P51158", "type": "external" } ], "mass": 24772.0, "length": 221, "protein_name": "Ras-related protein Rab-28", "gene_name": "Rab28", "organism": "Rat", "refseq_name": "ras-related protein Rab-28", "refseq_ac": [ { "id": "NP_446430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446430", "type": "external" } ], "gene_names_uniprotkb": "Rab28", "gene_names_refseq": "Rab28", "protein_names_uniprotkb": "Ras-related protein Rab-28; 3.6.5.2", "protein_names_refseq": "rab-26; ras-related protein Rab-28", "tax_id": 10116, "disease": "ciliopathy (Disease Ontology:DOID:0060340); cone-rod dystrophy 18 (Disease Ontology:DOID:0111024)", "pathway": " (rno:117049)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23457503;23746546;8647132", "class_list": "", "function": "Rab28 is novel regulator of NFkB nuclear transport in endothelial cells., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB28 is required for shedding and phagocytosis of cone cell outer segments (OS) discs in the retina (By similarity). Also participates in nuclear factor kappa-B p65/RELA nuclear transport in endothelial cells (PubMed:23457503)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0035253 ciliary rootlet;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51158-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51433-1", "uniprot_id": [ { "id": "PA2G5_RAT", "url": "https://www.uniprot.org/uniprot/P51433", "type": "external" } ], "mass": 15996.0, "length": 137, "protein_name": "Phospholipase A2 group V", "gene_name": "Pla2g5", "organism": "Rat", "refseq_name": "phospholipase A2 group V precursor", "refseq_ac": [ { "id": "NP_058870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058870", "type": "external" } ], "gene_names_uniprotkb": "Pla2g5", "gene_names_refseq": "PLA2-10; Pla2g5", "protein_names_uniprotkb": "Phospholipase A2 group V; 3.1.1.4; PLA2-10; Phosphatidylcholine 2-acylhydrolase 5", "protein_names_refseq": "calcium-dependent phospholipase A2; group V phospholipase A2; phosphatidylcholine 2-acylhydrolase 5; phospholipase A2 group V precursor; phospholipase A2, group 5", "tax_id": 10116, "disease": "familial benign fleck retina (Disease Ontology:DOID:0111677)", "pathway": " (rno:29354); (R-RNO-1482788); (R-RNO-1482801); (R-RNO-1482839); (R-RNO-1482922); (R-RNO-1482925); (R-RNO-1483166)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "23567287;7947992", "class_list": "", "function": "Prostaglandin E1 plays a role in therapy of coronary heart disease and atherosclerosis by regulating serum estrogen and FSH levels, and myocardium sPLA2-V protein expression., [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (By similarity). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes. Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane (By similarity). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells. In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way. In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (By similarity). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis. May regulate antigen processing in antigen-presenting cells. In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6DQ96", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005543 phospholipid binding;GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006663 platelet activating factor biosynthetic process;GO:0034638 phosphatidylcholine catabolic process;GO:0006631 fatty acid metabolic process;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0042130 negative regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51433-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51607-1", "uniprot_id": [ { "id": "RENBP_RAT", "url": "https://www.uniprot.org/uniprot/P51607", "type": "external" } ], "mass": 48391.0, "length": 419, "protein_name": "N-acylglucosamine 2-epimerase", "gene_name": "Renbp", "organism": "Rat", "refseq_name": "N-acylglucosamine 2-epimerase", "refseq_ac": [ { "id": "NP_112357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112357", "type": "external" } ], "gene_names_uniprotkb": "Renbp", "gene_names_refseq": "Renbp", "protein_names_uniprotkb": "N-acylglucosamine 2-epimerase; 5.1.3.8; AGE; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; Renin-binding protein; RnBP", "protein_names_refseq": "AGE; N-acetyl-D-glucosamine 2-epimerase; N-acylglucosamine 2-epimerase; glcNAc 2-epimerase; rnBP", "tax_id": 10116, "disease": "", "pathway": " (rno:81759); (R-RNO-446210)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12866502;1400260;1723410", "class_list": "", "function": "Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The gene encoding renin binding protein (Renbp) has been assigned to rat chromosome Xq37., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.1.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.8", "type": "external" } ], "go_molecular_function": "GO:0050121 N-acylglucosamine 2-epimerase activity;GO:0004857 enzyme inhibitor activity;GO:0005524 ATP binding;GO:0030414 peptidase inhibitor activity;GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0005975 carbohydrate metabolic process;GO:0043086 negative regulation of catalytic activity;GO:0010951 negative regulation of endopeptidase activity;GO:0006051 N-acetylmannosamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P51607-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52504-1", "uniprot_id": [ { "id": "NDUS6_RAT", "url": "https://www.uniprot.org/uniprot/P52504", "type": "external" } ], "mass": 12783.0, "length": 116, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "gene_name": "Ndufs6-ps1; Ndufs6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ndufs6-ps1; Ndufs6; Ip13", "gene_names_refseq": "", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; CI-13kD-A; Complex I-13kD-A; NADH-ubiquinone oxidoreductase 13 kDa-A subunit", "protein_names_refseq": "", "tax_id": 10116, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 9 (Disease Ontology:DOID:0112073); arteriosclerosis (Disease Ontology:DOID:2349); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7607554", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0072359 circulatory system development;GO:0097168 mesenchymal stem cell proliferation;GO:0006631 fatty acid metabolic process;GO:0006936 muscle contraction;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P52504-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54001-1", "uniprot_id": [ { "id": "P4HA1_RAT", "url": "https://www.uniprot.org/uniprot/P54001", "type": "external" } ], "mass": 60898.0, "length": 534, "protein_name": "Prolyl 4-hydroxylase subunit alpha-1", "gene_name": "P4ha1", "organism": "Rat", "refseq_name": "prolyl 4-hydroxylase subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_742059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742059", "type": "external" } ], "gene_names_uniprotkb": "P4ha1; P4ha", "gene_names_refseq": "P4ha1; PHalphaI", "protein_names_uniprotkb": "Prolyl 4-hydroxylase subunit alpha-1; 1.14.11.2; 4-PH alpha-1; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1", "protein_names_refseq": "4-PH alpha-1; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1; prolyl 4-hydroxylase alpha subunit; prolyl 4-hydroxylase subunit alpha-1 precursor; prolyl 4-hydroxylase, alpha polypeptide I", "tax_id": 10116, "disease": "", "pathway": " (rno:64475)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "38843836;7959029", "class_list": "", "function": "Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6AZ74", "ec_number_list": [ { "id": "1.14.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.2", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0042802 identical protein binding;GO:0031418 L-ascorbic acid binding;GO:0004656 procollagen-proline 4-dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0016222 procollagen-proline 4-dioxygenase complex", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P54001-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54777-1", "uniprot_id": [ { "id": "PEX6_RAT", "url": "https://www.uniprot.org/uniprot/P54777", "type": "external" } ], "mass": 104426.0, "length": 978, "protein_name": "Peroxisomal ATPase PEX6", "gene_name": "Pex6", "organism": "Rat", "refseq_name": "peroxisomal ATPase PEX6", "refseq_ac": [ { "id": "NP_476466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476466", "type": "external" } ], "gene_names_uniprotkb": "Pex6", "gene_names_refseq": "Paf-2; Paf2; Pex6", "protein_names_uniprotkb": "Peroxisomal ATPase PEX6; 3.6.4.-; PAF-2; Peroxin-6; Peroxisomal biogenesis factor 6; Peroxisome assembly factor 2", "protein_names_refseq": "peroxin-6; peroxisomal ATPase PEX6; peroxisomal-type ATPase 1; peroxisome assembly factor 2-like; peroxisome assembly factor 2", "tax_id": 10116, "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); peroxisome biogenesis disorder 4A (Disease Ontology:DOID:0080479); Heimler syndrome 2 (Disease Ontology:DOID:0080624); Peroxisome biogenesis disorder 4B (Disease Ontology:DOID:0081433); peroxisomal disease (Disease Ontology:DOID:906)", "pathway": " (rno:117265); (R-RNO-9033241)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "29393594;7493019", "class_list": "", "function": "Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O55097", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0097733 photoreceptor cell cilium;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005829 cytosol", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0043335 protein unfolding;GO:0007031 peroxisome organization;GO:0050821 protein stabilization;GO:0006625 protein targeting to peroxisome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P54777-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56225-1", "uniprot_id": [ { "id": "PO5F2_RAT", "url": "https://www.uniprot.org/uniprot/P56225", "type": "external" } ], "mass": 37001.0, "length": 335, "protein_name": "POU domain, class 5, transcription factor 2", "gene_name": "Pou5f2", "organism": "Rat", "refseq_name": "POU domain, class 5, transcription factor 2", "refseq_ac": [ { "id": "NP_001075220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075220", "type": "external" } ], "gene_names_uniprotkb": "Pou5f2; Sprm1", "gene_names_refseq": "Pou5f2; Sprm-1; Sprm1", "protein_names_uniprotkb": "POU domain, class 5, transcription factor 2; SPRM-1; Sperm 1 POU domain transcription factor", "protein_names_refseq": "POU domain, class 5, transcription factor 2; sperm 1 POU-domain transcription factor; sperm-associated POU domain protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:680620)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7902581", "class_list": "", "function": "Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56225-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56700-1", "uniprot_id": [ { "id": "RGS16_RAT", "url": "https://www.uniprot.org/uniprot/P56700", "type": "external" } ], "mass": 22400.0, "length": 199, "protein_name": "Regulator of G protein signaling 16", "gene_name": "Rgs16", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rgs16; Rgsr", "gene_names_refseq": "", "protein_names_uniprotkb": "Regulator of G protein signaling 16; RGS-r; RGS16; Retinal-specific RGS; Retinally abundant regulator of G protein signaling", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:360857); (R-RNO-416476); (R-RNO-418594); (R-RNO-418597)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8917514", "class_list": "", "function": "Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0043547 positive regulation of GTPase activity;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56700-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59382-1", "uniprot_id": [ { "id": "PXMP4_RAT", "url": "https://www.uniprot.org/uniprot/P59382", "type": "external" } ], "mass": 24136.0, "length": 212, "protein_name": "Peroxisomal membrane protein 4", "gene_name": "Pxmp4", "organism": "Rat", "refseq_name": "peroxisomal membrane protein 4", "refseq_ac": [ { "id": "NP_757377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_757377", "type": "external" } ], "gene_names_uniprotkb": "Pxmp4; Pmp24", "gene_names_refseq": "Pxmp4", "protein_names_uniprotkb": "Peroxisomal membrane protein 4; 24 kDa peroxisomal intrinsic membrane protein", "protein_names_refseq": "24 kDa peroxisomal intrinsic membrane protein; peroxisomal membrane protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:282634); (R-RNO-9603798)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10366717", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0046485 ether lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P59382-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59798-1", "uniprot_id": [ { "id": "SELK_RAT", "url": "https://www.uniprot.org/uniprot/P59798", "type": "external" } ], "mass": 10626.0, "length": 94, "protein_name": "Selenoprotein K", "gene_name": "Selenok", "organism": "Rat", "refseq_name": "selenoprotein K", "refseq_ac": [ { "id": "NP_997472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997472", "type": "external" } ], "gene_names_uniprotkb": "Selenok; Selk", "gene_names_refseq": "Selenok; Selk", "protein_names_uniprotkb": "Selenoprotein K; SelK", "protein_names_refseq": "heat shock protein; selenoprotein K", "tax_id": 10116, "disease": "", "pathway": " (rno:290549)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Multiple pseudogenes of this locus have been identified. [provided by RefSeq, Aug 2017]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5I0Q3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010742 macrophage derived foam cell differentiation;GO:0051223 regulation of protein transport;GO:0006979 response to oxidative stress;GO:0030335 positive regulation of cell migration;GO:2000406 positive regulation of T cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P59798-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60892-1", "uniprot_id": [ { "id": "PRPS1_RAT", "url": "https://www.uniprot.org/uniprot/P60892", "type": "external" } ], "mass": 34834.0, "length": 318, "protein_name": "Ribose-phosphate pyrophosphokinase 1", "gene_name": "Prps1", "organism": "Rat", "refseq_name": "ribose-phosphate pyrophosphokinase 1", "refseq_ac": [ { "id": "NP_058939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058939", "type": "external" } ], "gene_names_uniprotkb": "Prps1", "gene_names_refseq": "Prps1", "protein_names_uniprotkb": "Ribose-phosphate pyrophosphokinase 1; 2.7.6.1; PRS-I; Phosphoribosyl pyrophosphate synthase I", "protein_names_refseq": "PRS-I; phosphoribosyl pyrophosphate synthase I; phosphoribosyl pyrophosphate synthetase I; ribose-phosphate pyrophosphokinase 1", "tax_id": 10116, "disease": "Arts syndrome (Disease Ontology:DOID:0050647); Charcot-Marie-Tooth disease X-linked recessive 5 (Disease Ontology:DOID:0110210); phosphoribosylpyrophosphate synthetase superactivity (Disease Ontology:DOID:0111260); X-linked deafness 1 (Disease Ontology:DOID:0111739); retinitis pigmentosa (Disease Ontology:DOID:10584); gout (Disease Ontology:DOID:13189)", "pathway": " (rno:29562); (rno:314140); (R-RNO-73843)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "2154494;2555779;2822704", "class_list": "", "function": "Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09329;Q5M8A4", "ec_number_list": [ { "id": "2.7.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.6.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0016208 AMP binding", "go_cellular_component": "GO:0002189 ribose phosphate diphosphokinase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007399 nervous system development;GO:0006098 pentose-phosphate shunt;GO:0031100 animal organ regeneration;GO:0006144 purine nucleobase metabolic process;GO:0034418 urate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P60892-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61480-1", "uniprot_id": [ { "id": "WDR12_RAT", "url": "https://www.uniprot.org/uniprot/P61480", "type": "external" } ], "mass": 47563.0, "length": 423, "protein_name": "Ribosome biogenesis protein WDR12", "gene_name": "Wdr12", "organism": "Rat", "refseq_name": "ribosome biogenesis protein WDR12", "refseq_ac": [ { "id": "NP_955442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955442", "type": "external" } ], "gene_names_uniprotkb": "Wdr12; WDR12", "gene_names_refseq": "Wdr12", "protein_names_uniprotkb": "Ribosome biogenesis protein WDR12; WD repeat-containing protein 12", "protein_names_refseq": "WD repeat-containing protein 12; ribosome biogenesis protein WDR12", "tax_id": 10116, "disease": "", "pathway": " (rno:363237); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25915632;29393594", "class_list": "", "function": "Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP, UniProtKB, UniProtKB]; WDR12 triggers distinct deterioration of cardiac function in adult rat heart. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0051726 regulation of cell cycle;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61480-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62074-1", "uniprot_id": [ { "id": "TIM10_RAT", "url": "https://www.uniprot.org/uniprot/P62074", "type": "external" } ], "mass": 10333.0, "length": 90, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim10", "gene_name": "Timm10", "organism": "Rat", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim10", "refseq_ac": [ { "id": "NP_742071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742071", "type": "external" } ], "gene_names_uniprotkb": "Timm10; Tim10", "gene_names_refseq": "Tim10; Timm10", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim10", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim10; small zinc finger-like protein; translocase of inner mitochondrial membrane 10 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:64464)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10611480", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKD3;Q9WV99;Q9WVA0;Q9Y5J8", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051087 protein-folding chaperone binding;GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62074-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62076-1", "uniprot_id": [ { "id": "TIM13_RAT", "url": "https://www.uniprot.org/uniprot/P62076", "type": "external" } ], "mass": 10458.0, "length": 95, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim13", "gene_name": "Timm13", "organism": "Rat", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim13", "refseq_ac": [ { "id": "NP_665724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665724", "type": "external" } ], "gene_names_uniprotkb": "Timm13; Tim13a; Timm13a", "gene_names_refseq": "Timm13", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim13", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim13; translocase of inner mitochondrial membrane 13 homolog", "tax_id": 10116, "disease": "deafness-dystonia-optic neuronopathy syndrome (Disease Ontology:DOID:0050757)", "pathway": " (rno:252928)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10611480", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9UHL8;Q9WTL1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62076-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62275-1", "uniprot_id": [ { "id": "RS29_RAT", "url": "https://www.uniprot.org/uniprot/P62275", "type": "external" } ], "mass": 6677.0, "length": 56, "protein_name": "Small ribosomal subunit protein uS14", "gene_name": "ENSRNOG00000070428; Rps29", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS14", "refseq_ac": [ { "id": "NP_037008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037008", "type": "external" } ], "gene_names_uniprotkb": "ENSRNOG00000070428; Rps29", "gene_names_refseq": "Rps29", "protein_names_uniprotkb": "Small ribosomal subunit protein uS14; 40S ribosomal protein S29", "protein_names_refseq": "40S ribosomal protein S29; small ribosomal subunit protein uS14", "tax_id": 10116, "disease": "spinocerebellar ataxia 45 (Disease Ontology:DOID:0080287); Diamond-Blackfan anemia 13 (Disease Ontology:DOID:0111889)", "pathway": " (rno:25348); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 1, "publication_id_list": "8441676", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P30054", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005840 ribosome;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62275-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62278-1", "uniprot_id": [ { "id": "RS13_RAT", "url": "https://www.uniprot.org/uniprot/P62278", "type": "external" } ], "mass": 17222.0, "length": 151, "protein_name": "Small ribosomal subunit protein uS15", "gene_name": "Rps13l1; Rps13", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS15", "refseq_ac": [ { "id": "NP_569116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569116", "type": "external" } ], "gene_names_uniprotkb": "Rps13l1; Rps13; LOC683961; Rps13", "gene_names_refseq": "Rps13", "protein_names_uniprotkb": "Small ribosomal subunit protein uS15; 40S ribosomal protein S13", "protein_names_refseq": "40S ribosomal protein S13; small ribosomal subunit protein uS15", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (rno:161477); (rno:683961); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "2403345;38843836", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P19116;Q02546;Q29200", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:1990932 5.8S rRNA binding;GO:0048027 mRNA 5'-UTR binding;GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0033119 negative regulation of RNA splicing;GO:0042274 ribosomal small subunit biogenesis;GO:0140236 translation at presynapse;GO:0140242 translation at postsynapse;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P62278-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62494-1", "uniprot_id": [ { "id": "RB11A_RAT", "url": "https://www.uniprot.org/uniprot/P62494", "type": "external" } ], "mass": 24394.0, "length": 216, "protein_name": "Ras-related protein Rab-11A", "gene_name": "Rab11a", "organism": "Rat", "refseq_name": "ras-related protein Rab-11A", "refseq_ac": [ { "id": "NP_112414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112414", "type": "external" } ], "gene_names_uniprotkb": "Rab11a; Rab11", "gene_names_refseq": "Rab11a", "protein_names_uniprotkb": "Ras-related protein Rab-11A; 24KG; 3.6.5.2; Rab-11", "protein_names_refseq": "24KG; rab-11; ras-related protein Rab-11A", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (rno:81830); (R-RNO-432040); (R-RNO-5620912); (R-RNO-5620916); (R-RNO-8854214); (R-RNO-8873719)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "11163216;12145319;14578858;17082457;1711847;20826437;30545898;32375403;37268020", "class_list": "", "function": "Identification and validation of Rab11a in Rat orofacial inflammatory pain model induced by CFA., [RefSeq, PubMed]; Kalirin Interacts with TRAPP and Regulates Rab11 and Endosomal Recycling. Publication Status: Online-Only, [RefSeq, PubMed]; PIgA-R traffics through postendosomal rab3D-, rab11a-, and syntaxin 2-associated compartments, implicating these proteins in the regulation of transcytosis., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB11A regulates endocytic recycling (PubMed:11163216). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC). Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (By similarity). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth. Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (By similarity). Also interacts with RABL3 to promote ciliary vesicle formation (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Which bridges Myo5b and the membrane-bound Rab11a. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P24410;Q9JLX1", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:0098978 glutamatergic synapse;GO:0098837 postsynaptic recycling endosome;GO:0000139 Golgi membrane;GO:0000922 spindle pole", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:1903438 positive regulation of mitotic cytokinetic process;GO:1990182 exosomal secretion;GO:0051223 regulation of protein transport;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P62494-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62516-1", "uniprot_id": [ { "id": "PO3F4_RAT", "url": "https://www.uniprot.org/uniprot/P62516", "type": "external" } ], "mass": 39417.0, "length": 361, "protein_name": "POU domain, class 3, transcription factor 4", "gene_name": "Pou3f4", "organism": "Rat", "refseq_name": "POU domain, class 3, transcription factor 4", "refseq_ac": [ { "id": "NP_058948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058948", "type": "external" } ], "gene_names_uniprotkb": "Pou3f4; Brn-4; Brn4; Otf9", "gene_names_refseq": "Pou3f4; RHS2", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 4; Brain-4; Brain-specific homeobox/POU domain protein 4; Brn-4; OTF-9; Oct-9; Octamer-binding protein 9; Octamer-binding transcription factor 9; RHS2 class III POU protein", "protein_names_refseq": "OTF-9; POU domain, class 3, transcription factor 4; RHS2 class III POU protein; brain-4; brain-specific homeobox/POU domain protein 4; brn-4; oct-9; octamer-binding protein 9; octamer-binding transcription factor 9", "tax_id": 10116, "disease": "X-linked deafness 2 (Disease Ontology:DOID:0111737)", "pathway": " (rno:29589)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1348858;1628619;18831054;20105446;21663595;31518606", "class_list": "", "function": "Brn-4 expression is required both for neuronal differentiation of NSCs and maturation of newborn neurons, and that there may be some regulatory factors in deafferented hippocampus that can regulate Brn-4 expression in neuronal progenitors., [RefSeq, PubMed]; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain., [UniProtKB]; Results indicated that Brn4 promoted the neuronal differentiation of neural stem cells via inhibition of CtBP2 and is a potential tool for generating neurons in cell replacement therapy of neurodegenerative diseases and brain injury, [RefSeq, PubMed]; Study showed after fimbria-fornix lesion, Brn-4 in deafferented hippocampus was upregulated & might play a role in inducing local progenitors to differentiate into neurons, which may compensate for loss of cholinergic afferent fibers or other dysfunctions, [RefSeq, PubMed]; The co-transduction of Nurr1 and Brn4 genes induces cell differentiation of neural stem cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25216", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:2001054 negative regulation of mesenchymal cell apoptotic process;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007605 sensory perception of sound;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P62516-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62603-1", "uniprot_id": [ { "id": "TRI26_RAT", "url": "https://www.uniprot.org/uniprot/P62603", "type": "external" } ], "mass": 62631.0, "length": 542, "protein_name": "Tripartite motif-containing protein 26", "gene_name": "Trim26", "organism": "Rat", "refseq_name": "tripartite motif-containing protein 26", "refseq_ac": [ { "id": "NP_001011665", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011665", "type": "external" } ], "gene_names_uniprotkb": "Trim26; Znf173", "gene_names_refseq": "Trim26; Znf173", "protein_names_uniprotkb": "Tripartite motif-containing protein 26; 2.3.2.27; Zinc finger protein 173", "protein_names_refseq": "tripartite motif protein 26; tripartite motif-containing protein 26; zinc finger protein 173", "tax_id": 10116, "disease": "", "pathway": " (rno:309586)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Also plays a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA. Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling. In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation. Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein. Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6MFZ0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62603-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62716-1", "uniprot_id": [ { "id": "PP2AB_RAT", "url": "https://www.uniprot.org/uniprot/P62716", "type": "external" } ], "mass": 35575.0, "length": 309, "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "gene_name": "Ppp2cb", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "refseq_ac": [ { "id": "NP_058736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058736", "type": "external" } ], "gene_names_uniprotkb": "Ppp2cb", "gene_names_refseq": "Pp2a2; Ppp2cb", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; 3.1.3.16; PP2A-beta", "protein_names_refseq": "PP2A-beta; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2A catalytic alpha subunit; protein phosphatase-2A-beta; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "tax_id": 10116, "disease": "hereditary spherocytosis type 1 (Disease Ontology:DOID:0110916); hereditary spherocytosis type 5 (Disease Ontology:DOID:0110920); hereditary spherocytosis (Disease Ontology:DOID:12971)", "pathway": " (rno:24673); (R-RNO-113501); (R-RNO-1295596); (R-RNO-141430); (R-RNO-141444); (R-RNO-180024); (R-RNO-195253); (R-RNO-196299); (R-RNO-198753); (R-RNO-202670); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-389356); (R-RNO-389513); (R-RNO-432142); (R-RNO-4641262); (R-RNO-5663220); (R-RNO-5673000); (R-RNO-5675221); (R-RNO-6804757); (R-RNO-6811558); (R-RNO-68877); (R-RNO-69231); (R-RNO-69273); (R-RNO-9648025); (R-RNO-9833482)", "pathway_count": 26, "publication_count": 5, "publication_id_list": "18245083;2174876;23349830;2554256;2849437", "class_list": "", "function": "Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB]; I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A, [RefSeq, PubMed]; Results suggest that the maintenance of PP2A subunit B by ferulic acid in ischemic brain injury plays an important role for the neuroprotective function of ferulic acid., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11082;Q6LDK0", "ec_number_list": [ { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.89", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.1.1.233", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.233", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0044325 transmembrane transporter binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0000278 mitotic cell cycle;GO:0010288 response to lead ion;GO:0010629 negative regulation of gene expression;GO:0042542 response to hydrogen peroxide", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62716-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62762-1", "uniprot_id": [ { "id": "VISL1_RAT", "url": "https://www.uniprot.org/uniprot/P62762", "type": "external" } ], "mass": 22142.0, "length": 191, "protein_name": "Visinin-like protein 1", "gene_name": "Vsnl1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vsnl1; Visl1", "gene_names_refseq": "", "protein_names_uniprotkb": "Visinin-like protein 1; 21 kDa CABP; NVL-1; NVP-1; Neural visinin-like protein 1; VILIP", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1375457", "class_list": "", "function": "Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P28677;P29103;P42323;Q9UM20", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0007417 central nervous system development;GO:0046676 negative regulation of insulin secretion;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62762-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62839-1", "uniprot_id": [ { "id": "UB2D2_RAT", "url": "https://www.uniprot.org/uniprot/P62839", "type": "external" } ], "mass": 16735.0, "length": 147, "protein_name": "Ubiquitin-conjugating enzyme E2 D2", "gene_name": "Ube2d2", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 D2", "refseq_ac": [ { "id": "NP_001380701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380701", "type": "external" } ], "gene_names_uniprotkb": "Ube2d2; Ubc4; Ubch4; Ubch5b", "gene_names_refseq": "E217kB; Ubc2e; Ube2d2", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 D2; (E3-independent) E2 ubiquitin-conjugating enzyme D2; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme D2; E2 ubiquitin-conjugating enzyme D2; E2(17)KB 2; ubc2e ubiquitin conjugating enzyme; ubiquitin carrier protein D2; ubiquitin-conjugating enzyme E2 D2; ubiquitin-conjugating enzyme E2(17)KB 2; ubiquitin-conjugating enzyme E2-17 kDa 2; ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); ubiquitin-protein ligase D2", "tax_id": 10116, "disease": "", "pathway": " (rno:641452); (R-RNO-1234176); (R-RNO-202424); (R-RNO-2871837); (R-RNO-5205685); (R-RNO-5357905); (R-RNO-5607764); (R-RNO-8866652); (R-RNO-8866654); (R-RNO-8951664); (R-RNO-9033241); (R-RNO-937041); (R-RNO-9705462); (R-RNO-983168); (R-RNO-9954709); (R-RNO-9954716)", "pathway_count": 16, "publication_count": 3, "publication_id_list": "18359941;27378730;7826319", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3 (By similarity). Mediates ubiquitination of PEX5., [UniProtKB, PubMed, UniProtKB]; UBE2D2 is not the cognate ubiquitinating enzyme for MuRF1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P51669", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62839-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62845-1", "uniprot_id": [ { "id": "RS15_RAT", "url": "https://www.uniprot.org/uniprot/P62845", "type": "external" } ], "mass": 17040.0, "length": 145, "protein_name": "Small ribosomal subunit protein uS19", "gene_name": "Rps15", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS19", "refseq_ac": [ { "id": "NP_058847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058847", "type": "external" } ], "gene_names_uniprotkb": "Rps15; Rig", "gene_names_refseq": "Rps15", "protein_names_uniprotkb": "Small ribosomal subunit protein uS19; 40S ribosomal protein S15; RIG protein", "protein_names_refseq": "40S ribosomal protein S15; RIG protein; insulinoma; small ribosomal subunit protein uS19", "tax_id": 10116, "disease": "chronic lymphocytic leukemia (Disease Ontology:DOID:1040); insulinoma (Disease Ontology:DOID:3892)", "pathway": " (rno:29285); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 3, "publication_id_list": "1390896;2044758;3019805", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11174", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0097371 MDM2/MDM4 family protein binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0045202 synapse;GO:0098794 postsynapse;GO:0005840 ribosome;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0006412 translation;GO:0097421 liver regeneration;GO:0006364 rRNA processing;GO:1901798 positive regulation of signal transduction by p53 class mediator;GO:0000056 ribosomal small subunit export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62845-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62907-1", "uniprot_id": [ { "id": "RL10A_RAT", "url": "https://www.uniprot.org/uniprot/P62907", "type": "external" } ], "mass": 24831.0, "length": 217, "protein_name": "Large ribosomal subunit protein uL1", "gene_name": "Rpl10al3; Rpl10a", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL1", "refseq_ac": [ { "id": "NP_112327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112327", "type": "external" } ], "gene_names_uniprotkb": "Rpl10al3; Rpl10a; Rpl10al3", "gene_names_refseq": "Rpl10a", "protein_names_uniprotkb": "Large ribosomal subunit protein uL1; 60S ribosomal protein L10a", "protein_names_refseq": "60S ribosomal protein L10a; large ribosomal subunit protein uL1", "tax_id": 10116, "disease": "", "pathway": " (rno:81729); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "20112406;8607874", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P52859;P53025", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0045471 response to ethanol;GO:0006412 translation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62907-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62966-1", "uniprot_id": [ { "id": "RABP1_RAT", "url": "https://www.uniprot.org/uniprot/P62966", "type": "external" } ], "mass": 15592.0, "length": 137, "protein_name": "Cellular retinoic acid-binding protein 1", "gene_name": "Crabp1", "organism": "Rat", "refseq_name": "cellular retinoic acid-binding protein 1", "refseq_ac": [ { "id": "NP_001099186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099186", "type": "external" } ], "gene_names_uniprotkb": "Crabp1", "gene_names_refseq": "Crabp1", "protein_names_uniprotkb": "Cellular retinoic acid-binding protein 1; CRABP-I; Cellular retinoic acid-binding protein I", "protein_names_refseq": "CRABP-I; cellular retinoic acid-binding protein 1; cellular retinoic acid-binding protein I", "tax_id": 10116, "disease": "cataract 22 multiple types (Disease Ontology:DOID:0110268)", "pathway": " (rno:25061); (R-RNO-5365859)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12684871;23977218;6274689", "class_list": "", "function": "Both CRABP II and CRABP I proteins and the mRNAs that encode them are present in postnatal rat olfactory epithelium, [RefSeq, PubMed]; CRABP-I expression controls the intracellular availability of retinoic acid and may be an important regulator of neuronal differentiation processes in the aged hippocampus. Publication Status: Online-Only, [RefSeq, PubMed]; Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02695;P02697;P15780", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0001972 retinoic acid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62966-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63033-1", "uniprot_id": [ { "id": "RHES_RAT", "url": "https://www.uniprot.org/uniprot/P63033", "type": "external" } ], "mass": 30197.0, "length": 266, "protein_name": "GTP-binding protein Rhes", "gene_name": "Rasd2", "organism": "Rat", "refseq_name": "GTP-binding protein Rhes", "refseq_ac": [ { "id": "NP_598252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598252", "type": "external" } ], "gene_names_uniprotkb": "Rasd2", "gene_names_refseq": "Rasd2; Rhes", "protein_names_uniprotkb": "GTP-binding protein Rhes; Ras homolog enriched in striatum; SE6C", "protein_names_refseq": "GTP-binding protein Rhes; SE6C; ras homolog enriched in striatum", "tax_id": 10116, "disease": "", "pathway": " (rno:171099)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10467249;11597759;11976265;14724584;15199135;16945334;18929545;19498170;22683505;24324270", "class_list": "", "function": "Data show that Rhes mRNA is expressed at high levels in hippocampus and cerebellum during the postnatal period., [RefSeq, PubMed]; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G protein-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Rhes is a novel striatal regulator of the AKT-mediated pathway in the striatum., [RefSeq, PubMed]; Rhes robustly binds the autophagy regulator Beclin-1, decreasing its inhibitory interaction with Bcl-2 independent of JNK-1 signaling., [RefSeq, PubMed]; Role in signal transduction of this novel Ras family member, [RefSeq, PubMed]; Study reports Rhes, which is localized selectively to the striatum, binds to mutant huntingtin (mHtt); Rhes induces sumoylation of mHtt leading to cytotoxicity; Rhes-mHtt interactions can account for the localized neuropathology of Huntington disease, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9WVD3", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0031624 ubiquitin conjugating enzyme binding;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0007626 locomotory behavior;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0001963 synaptic transmission, dopaminergic;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P63033-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63083-1", "uniprot_id": [ { "id": "S10A5_RAT", "url": "https://www.uniprot.org/uniprot/P63083", "type": "external" } ], "mass": 10812.0, "length": 93, "protein_name": "Protein S100-A5", "gene_name": "S100a5", "organism": "Rat", "refseq_name": "protein S100-A5", "refseq_ac": [ { "id": "NP_001099908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099908", "type": "external" } ], "gene_names_uniprotkb": "S100a5; S100d", "gene_names_refseq": "S100a5", "protein_names_uniprotkb": "Protein S100-A5; Protein S-100D; S100 calcium-binding protein A5", "protein_names_refseq": "protein S100-A5", "tax_id": 10116, "disease": "", "pathway": " (rno:295211)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10882717", "class_list": "", "function": "Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88945;P82540", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0043025 neuronal cell body", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63083-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63245-1", "uniprot_id": [ { "id": "RACK1_RAT", "url": "https://www.uniprot.org/uniprot/P63245", "type": "external" } ], "mass": 35077.0, "length": 317, "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "Rack1", "organism": "Rat", "refseq_name": "small ribosomal subunit protein RACK1", "refseq_ac": [ { "id": "NP_570090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570090", "type": "external" } ], "gene_names_uniprotkb": "Rack1; Gnb2l1", "gene_names_refseq": "Gnb2l1; Rack1", "protein_names_uniprotkb": "Small ribosomal subunit protein RACK1; Guanine nucleotide-binding protein subunit beta-2-like 1; Receptor for activated C kinase; Receptor of activated protein C kinase 1, N-terminally processed; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C 1", "protein_names_refseq": "guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide binding protein, beta polypeptide 2-like 1; guanine nucleotide-binding protein subunit beta-2-like 1; protein kinase C receptor; receptor for activated protein kinase C; receptor of activated protein C kinase 1; receptor of activated protein kinase C 1; small ribosomal subunit protein RACK1", "tax_id": 10116, "disease": "transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (rno:83427); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5626978); (R-RNO-9766229)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "15340087;17569602;18683930;30580718;32157145;37820423;38523594;38532543;39097918;8302854", "class_list": "", "function": "Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis., [RefSeq, PubMed]; Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances. Publication Status: Online-Only, [RefSeq, PubMed]; RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats., [RefSeq, PubMed]; Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights., [RefSeq, PubMed]; Research of STEAP3 interaction with Rab7A and RACK1 to modulate the MAPK and JAK/STAT signaling in Osteoarthritis., [RefSeq, PubMed]; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:15340087). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane. Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25388;P99049", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:1990630 IRE1-RACK1-PP2A complex;GO:0001891 phagocytic cup;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide;GO:0001934 positive regulation of protein phosphorylation;GO:0010629 negative regulation of gene expression;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P63245-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63324-1", "uniprot_id": [ { "id": "RS12_RAT", "url": "https://www.uniprot.org/uniprot/P63324", "type": "external" } ], "mass": 14525.0, "length": 132, "protein_name": "Small ribosomal subunit protein eS12", "gene_name": "Rps12l4; Rps12", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rps12l4; Rps12; Rps12l4", "gene_names_refseq": "", "protein_names_uniprotkb": "Small ribosomal subunit protein eS12; 40S ribosomal protein S12", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:65139)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2207170;3308890", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Subunit of the 40S ribosomal complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09388;P12728", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit;GO:0032040 small-subunit processome", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:1990145 maintenance of translational fidelity;GO:0042274 ribosomal small subunit biogenesis;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63324-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P67779-1", "uniprot_id": [ { "id": "PHB1_RAT", "url": "https://www.uniprot.org/uniprot/P67779", "type": "external" } ], "mass": 29820.0, "length": 272, "protein_name": "Prohibitin 1", "gene_name": "Phb1", "organism": "Rat", "refseq_name": "prohibitin 1", "refseq_ac": [ { "id": "NP_114039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114039", "type": "external" } ], "gene_names_uniprotkb": "Phb1; Phb", "gene_names_refseq": "Phb1; Phb", "protein_names_uniprotkb": "Prohibitin 1", "protein_names_refseq": "prohibitin 1; prohibitin", "tax_id": 10116, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); sporadic breast cancer (Disease Ontology:DOID:8029); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (rno:25344); (R-RNO-5673000); (R-RNO-8949664)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "11302691;19423663;1996099;22673903;26446791;27044659;27213235;30967257;32173312;34219469;34502162;36453777", "class_list": "", "function": "In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Regulates mitochondrial respiration activity playing a role in cellular aging. The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (By similarity). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses. Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells., [UniProtKB, UniProtKB]; In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation., [UniProtKB, UniProtKB]; PHB1 contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells which involves AKT phosphorylation, [RefSeq, PubMed]; Prohibitin-1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis., [RefSeq, PubMed]; Prohibitin1 maintains mitochondrial quality in isoproterenol-induced cardiac hypertrophy in H9C2 cells., [RefSeq, PubMed]; Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus. Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity) (PubMed:1996099). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (PubMed:32173312)., [UniProtKB, PubMed, PubMed, UniProtKB]; This study concluded that prohibitin is an autoantigen that cross-reacts with H1N1 influenza virus hemagglutinin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P24142;Q4V8M6", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0046982 protein heterodimerization activity;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0001851 complement component C3b binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0032740 positive regulation of interleukin-17 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P67779-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70563-1", "uniprot_id": [ { "id": "NUDT6_RAT", "url": "https://www.uniprot.org/uniprot/P70563", "type": "external" } ], "mass": 35292.0, "length": 313, "protein_name": "Nudix hydrolase 6", "gene_name": "Nudt6", "organism": "Rat", "refseq_name": "nudix hydrolase 6", "refseq_ac": [ { "id": "NP_852028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852028", "type": "external" } ], "gene_names_uniprotkb": "Nudt6", "gene_names_refseq": "Gfg; Nudt6", "protein_names_uniprotkb": "Nudix hydrolase 6; 3.6.1.18; 3.6.1.22; FAD diphosphatase NUDT6; NADH pyrophosphatase NUDT6; Nucleoside diphosphate-linked moiety X motif 6; Nudix motif 6; Protein GFG", "protein_names_refseq": "FAD diphosphatase NUDT6; NADH pyrophosphatase NUDT6; antisense basic fibroblast growth factor; nucleoside diphosphate-linked moiety X motif 6; nudix (nucleoside diphosphate linked moiety X)-type motif 6; nudix hydrolase 6; nudix motif 6", "tax_id": 10116, "disease": "", "pathway": " (rno:207120)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10854699;17306451;17569023;18215310;38468384;8660369;9406864", "class_list": "", "function": "FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling., [RefSeq, PubMed]; May contribute to the regulation of cell proliferation., [UniProtKB, UniProtKB]; Mediates the hydrolysis of some nucleoside diphosphate derivatives, such as NADH and FAD (in vitro). May modulate the subcellular levels of redox dinucleotides and control the mitochondrial concentrations of these compounds. May contribute to the regulation of cell proliferation., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; The results suggest that the endogenous FGF antisense RNA may play a significant functional role in the regulation of FGF-2 dependent cell proliferation in FGF-2 expressing cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZD7", "ec_number_list": [ { "id": "3.6.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.22", "type": "external" }, { "id": "2.7.7.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.2", "type": "external" }, { "id": "3.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.18", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0047631 ADP-ribose diphosphatase activity;GO:0051287 NAD binding;GO:0035529 NADH pyrophosphatase activity;GO:0047884 FAD diphosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005634 nucleus", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P70563-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70597-1", "uniprot_id": [ { "id": "PE2R1_RAT", "url": "https://www.uniprot.org/uniprot/P70597", "type": "external" } ], "mass": 43048.0, "length": 405, "protein_name": "Prostaglandin E2 receptor EP1 subtype", "gene_name": "Ptger1", "organism": "Rat", "refseq_name": "prostaglandin E2 receptor EP1 subtype", "refseq_ac": [ { "id": "NP_001265404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265404", "type": "external" } ], "gene_names_uniprotkb": "Ptger1", "gene_names_refseq": "EP1; Ptger1", "protein_names_uniprotkb": "Prostaglandin E2 receptor EP1 subtype; PGE receptor EP1 subtype; PGE2 receptor EP1 subtype; Prostanoid EP1 receptor", "protein_names_refseq": "EP1 prostanoid receptor; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1 (subtype EP1); prostaglandin E receptor EP1 subtype; prostaglandin E2 receptor EP1 subtype; prostanoid EP1 receptor", "tax_id": 10116, "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); myelodysplastic syndrome (Disease Ontology:DOID:0050908); autosomal recessive congenital ichthyosis (Disease Ontology:DOID:0060655); cerebrooculofacioskeletal syndrome 2 (Disease Ontology:DOID:0080912); xeroderma pigmentosum group D (Disease Ontology:DOID:0110845); photosensitive trichothiodystrophy 1 (Disease Ontology:DOID:0111873); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); gastric ulcer (Disease Ontology:DOID:10808); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); acoustic neuroma (Disease Ontology:DOID:12689); Down syndrome (Disease Ontology:DOID:14250); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); ovary epithelial cancer (Disease Ontology:DOID:2152); photosensitive trichothiodystrophy (Disease Ontology:DOID:2960); Cockayne syndrome (Disease Ontology:DOID:2962); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); skin disease (Disease Ontology:DOID:37); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); myelofibrosis (Disease Ontology:DOID:4971); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:25637); (R-RNO-391908); (R-RNO-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "32165825;35537317;37764741;8940129;9537820", "class_list": "", "function": "Alcohol reinstatement after prolonged abstinence from alcohol drinking by female adolescent rats: Roles of cyclooxygenase-2 and the prostaglandin E2 receptor 1., [RefSeq, PubMed]; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function (By similarity). Implicated the smooth muscle contractile response to PGE2 in various tissues. Isoform 1 and isoform 2 have identical ligand binding properties, but isoform 2 lacks coupling to calcium mobilization and may therefore attenuate the action of PGE2 on tissues., [UniProtKB]; Role of the PGE2 receptor in ischemia-reperfusion injury of the rat retina. Publication Status: Online-Only, [RefSeq, PubMed]; The Epigenetic Legacy of Maternal Protein Restriction: Renal Ptger1 DNA Methylation Changes in Hypertensive Rat Offspring. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P97537", "ec_number_list": [], "go_molecular_function": "GO:0031748 D1 dopamine receptor binding;GO:0004957 prostaglandin E receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0032496 response to lipopolysaccharide;GO:0070256 negative regulation of mucus secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P70597-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80204-1", "uniprot_id": [ { "id": "TGFR1_RAT", "url": "https://www.uniprot.org/uniprot/P80204", "type": "external" } ], "mass": 56000.0, "length": 501, "protein_name": "TGF-beta receptor type-1", "gene_name": "Tgfbr1", "organism": "Rat", "refseq_name": "TGF-beta receptor type-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001416585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416585", "type": "external" } ], "gene_names_uniprotkb": "Tgfbr1", "gene_names_refseq": "Alk5; Skr4; Tgfbr1; Tgfr-1; tbetaR-I", "protein_names_uniprotkb": "TGF-beta receptor type-1; 2.7.11.30; SKR4; Serine/threonine-protein kinase receptor R4; TGF-beta receptor type I; TGF-beta type I receptor; TGFR-1; TbetaR-I; Transforming growth factor-beta receptor type I", "protein_names_refseq": "TGF-beta receptor type I; TGF-beta receptor type-1 isoform 1 precursor; TGF-beta receptor type-1-like; TGF-beta receptor type-1; TGF-beta type I receptor; activin receptor-like kinase 5; serine/threonine-protein kinase receptor R4; transforming growth factor, beta receptor I; transforming growth factor-beta receptor type I", "tax_id": 10116, "disease": "Loeys-Dietz syndrome (Disease Ontology:DOID:0050466); Loeys-Dietz syndrome 1 (Disease Ontology:DOID:0070235); urinary bladder cancer (Disease Ontology:DOID:11054); leiomyoma (Disease Ontology:DOID:127); osteochondrodysplasia (Disease Ontology:DOID:2256); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); Lynch syndrome (Disease Ontology:DOID:3883); systemic scleroderma (Disease Ontology:DOID:418); kidney disease (Disease Ontology:DOID:557); Ferguson-Smith tumor (Disease Ontology:DOID:5585); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (R-RNO-2173788); (R-RNO-2173789); (R-RNO-2173791); (R-RNO-5689880); (R-RNO-9839389)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "18469808;34678242;35122773;36293138;37676431;39025366;8395914;8756725", "class_list": "", "function": "Enriched environment treatment promotes neurofunctional recovery by regulating the ALK5/Smad2/3/Gadd45beta signaling pathway in rats with cerebral ischemia /reperfusion injury., [RefSeq, PubMed]; GDF11 Regulates PC12 Neural Stem Cells via ALK5-Dependent PI3K-Akt Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFbeta pathway inhibition., [RefSeq, PubMed]; MicroRNA-210-5p alleviates cardiac fibrosis via targeting transforming growth factor-beta type I receptor in rats on high sodium chloride (NaCl)-based diet. Erratum:[Eur J Pharmacol. 2025 Jul 15;999:177706. doi: 10.1016/j.ejphar.2025.177706. PMID: 40383684], [RefSeq, PubMed]; MicroRNA-499-5p inhibits transforming growth factor-beta1-induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFbeta-R1. Erratum:[Mol Biol Rep. 2024 Apr 20;51(1):552. doi: 10.1007/s11033-024-09226-w. PMID: 38642166], [RefSeq, PubMed]; Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0009986 cell surface", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0060017 parathyroid gland development;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0006468 protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P80204-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81278-1", "uniprot_id": [ { "id": "PRRP_RAT", "url": "https://www.uniprot.org/uniprot/P81278", "type": "external" } ], "mass": 9215.0, "length": 83, "protein_name": "Prolactin-releasing peptide", "gene_name": "Prlh", "organism": "Rat", "refseq_name": "prolactin-releasing peptide precursor", "refseq_ac": [ { "id": "NP_071558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071558", "type": "external" } ], "gene_names_uniprotkb": "Prlh; Prh", "gene_names_refseq": "Prh; Prlh; prrp", "protein_names_uniprotkb": "Prolactin-releasing peptide; PrRP; Prolactin-releasing hormone", "protein_names_refseq": "preproprolactin-releasing peptide; prolactin-releasing peptide precursor; prolactin-releasing peptide", "tax_id": 10116, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:63850); (R-RNO-375276)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10498338;11178959;12619141;12668869;21056089;24877622;25217033;32200401;32890590;9607765", "class_list": "", "function": "Brainstem prolactin-releasing peptide contributes to cancer anorexia-cachexia syndrome in rats., [RefSeq, PubMed]; Colocalized neurotransmitters in the hindbrain cooperate in adaptation to chronic hypernatremia., [RefSeq, PubMed]; Not true neuroendocrine regulators of stress hormone secretion in the rat but, instead, act centrally to alter the release of neuroendocrine factors that do act in the pituitary gland to control prolactin and ACTH release., [RefSeq, PubMed]; Possible involvement of Stat3 and Prlh1/Chgb up-regulation in the transition from short to repeated stress activation. Publication Status: Online-Only, [RefSeq, PubMed]; PrRP gene expression was seen in the embryonic caudal solitary tract nucleus, medullary reticular formation, pontine isthmus and liver, kidney, and testis., [RefSeq, PubMed]; PrRP increases the amplitude of the GABAA receptor-mediated inhibitory postsynaptic current in both ventrobasal nucleus and reticular thalamic nucleus neurons., [RefSeq, PubMed]; Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL., [UniProtKB]; The medial amygdala-medullary PrRP-synthesizing neuron pathway plays an important role in neuroendocrine responses to contextual conditioned fear, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3Y0", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0031861 prolactin-releasing peptide receptor binding;GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0048483 autonomic nervous system development;GO:0006629 lipid metabolic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0040014 regulation of multicellular organism growth;GO:0001894 tissue homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P81278-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81556-1", "uniprot_id": [ { "id": "TIMP4_RAT", "url": "https://www.uniprot.org/uniprot/P81556", "type": "external" } ], "mass": 25723.0, "length": 224, "protein_name": "Metalloproteinase inhibitor 4", "gene_name": "Timp4", "organism": "Rat", "refseq_name": "metalloproteinase inhibitor 4 precursor", "refseq_ac": [ { "id": "NP_001102863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102863", "type": "external" } ], "gene_names_uniprotkb": "Timp4", "gene_names_refseq": "Timp-4; Timp4", "protein_names_uniprotkb": "Metalloproteinase inhibitor 4; TIMP-4; Tissue inhibitor of metalloproteinases 4", "protein_names_refseq": "metalloproteinase inhibitor 4 precursor; metalloproteinase inhibitor 4; tissue inhibitor of metalloproteinase 4; tissue inhibitor of metalloproteinases 4", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); renal hypertension (Disease Ontology:DOID:1073); endometrial cancer (Disease Ontology:DOID:1380); nephroblastoma (Disease Ontology:DOID:2154); endometrial carcinoma (Disease Ontology:DOID:2871); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); abdominal aortic aneurysm (Disease Ontology:DOID:7693); prostate carcinoma in situ (Disease Ontology:DOID:8634)", "pathway": " (rno:680130)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "23427085;24126801;25028660;38069250;9503367", "class_list": "", "function": "Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Defect of TIMP4 Is Associated with High Myopia and Participates in Rat Ocular Development in a Dose-Dependent Manner. Publication Status: Online-Only, [RefSeq, PubMed]; OPG regulated the proliferation of chondrocytes via MEK/ERK signaling, and directly affected chondrocytes by influencing the expression profile of ADAMTS-5 and TIMP-4., [RefSeq, PubMed]; The immunohistochemistry demonstrated greater expression of MMP-2 than MMP-9 and MMP-14 in all masseter muscles and there were few differences in the staining of 4 TIMPs., [RefSeq, PubMed]; These findings provide evidence of a novel causal role of TIMP-4 and TIMP-3 in the direct inhibitory effect of hypoxia on cardiomyocyte proliferation in the developing heart, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008191 metalloendopeptidase inhibitor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0030017 sarcomere;GO:0005576 extracellular region", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0032496 response to lipopolysaccharide;GO:0034097 response to cytokine;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P81556-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82458-1", "uniprot_id": [ { "id": "TRI18_RAT", "url": "https://www.uniprot.org/uniprot/P82458", "type": "external" } ], "mass": 75211.0, "length": 667, "protein_name": "E3 ubiquitin-protein ligase Midline-1", "gene_name": "Mid1", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase Midline-1 isoform 1", "refseq_ac": [ { "id": "NP_075216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075216", "type": "external" } ], "gene_names_uniprotkb": "Mid1; Fxy; Trim18", "gene_names_refseq": "Fxy; Mid1; Midline1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Midline-1; 2.3.2.27; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; Tripartite motif-containing protein 18", "protein_names_refseq": "E3 ubiquitin-protein ligase Midline-1 isoform 1; E3 ubiquitin-protein ligase Midline-1; Finger on X and Y (in rat only on X); RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; midline 1 (Opitz/BBB syndrome); tripartite motif-containing protein 18", "tax_id": 10116, "disease": "Opitz GBBB syndrome (Disease Ontology:DOID:0080697); microphthalmia (Disease Ontology:DOID:10629); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:54252)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10508587", "class_list": "", "function": "Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0007026 negative regulation of microtubule depolymerization;GO:0070507 regulation of microtubule cytoskeleton organization;GO:0032874 positive regulation of stress-activated MAPK cascade;GO:0035372 protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P82458-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82598-1", "uniprot_id": [ { "id": "NGIF_RAT", "url": "https://www.uniprot.org/uniprot/P82598", "type": "external" } ], "mass": 914.0, "length": 8, "protein_name": "Non-arginase growth inhibitory factor", "gene_name": "", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Non-arginase growth inhibitory factor; NAGIF", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10731662", "class_list": "", "function": "Inhibitor of the proliferation of hepatic stellate cells (HSC). Also inhibits the growth of bovine endothelial cells and 3T6 fibroblasts., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P82598-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83858-1", "uniprot_id": [ { "id": "QRFPR_RAT", "url": "https://www.uniprot.org/uniprot/P83858", "type": "external" } ], "mass": 49311.0, "length": 433, "protein_name": "Pyroglutamylated RF-amide peptide receptor", "gene_name": "Qrfpr", "organism": "Rat", "refseq_name": "pyroglutamylated RF-amide peptide receptor", "refseq_ac": [ { "id": "NP_937842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937842", "type": "external" } ], "gene_names_uniprotkb": "Qrfpr; Gpr103", "gene_names_refseq": "AQ27; Gpr103; Qrfpr", "protein_names_uniprotkb": "Pyroglutamylated RF-amide peptide receptor; AQ27; G protein-coupled receptor 103; Orexigenic neuropeptide QRFP receptor; SP9155", "protein_names_refseq": "G-protein coupled receptor 103; QRFP receptor; SP9155; orexigenic neuropeptide QRFP receptor; pyroglutamylated RF-amide peptide receptor", "tax_id": 10116, "disease": "bone structure disease (Disease Ontology:DOID:0080010)", "pathway": " (rno:310327); (R-RNO-389397); (R-RNO-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12714592;12960173;16648250;16996040;17534937;25041985;25895849", "class_list": "", "function": "Four genes were significantly downregulated in the PFC [prefrontal cortex ]of SHR[spontaneously hypertensive rat ] compared to Wistar rats (Gad2, Chrnb4, Slc5a7, and Qrfpr) and none in nucleus accumbens., [RefSeq, PubMed]; Prepro-QRFP mRNA and GPR103a mRNA are expressed in L6 cells, though GPR103b mRNA was not detected. Using complementary assays, co-incubation with QRFP-26, increased insulin's ability to induce glycogen synthesis and 2-deoxyglucose uptake in L6 cells, [RefSeq, PubMed]; QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome, [RefSeq, PubMed]; QRFP mRNA was highly expressed in the hypothalamus; QRFP receptor mRNA was highly expressed in the adrenal gland. Data suggests that QRFP and its receptor have a regulatory function in the rat adrenal gland., [RefSeq, PubMed]; Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels., [UniProtKB, PubMed]; The expression of GPR103 mRNA was more discrete, notably in the midbrain, the pons, and the medulla oblongata., [RefSeq, PubMed]; We found an additional receptor with high homology for GPR103 in rat. This receptor increases inositol triphosphate production in transfected cells in presence of QRFP(26) and its mRNA was particularly enriched in the brain.(GPR103 protein, rat), [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004983 neuropeptide Y receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0097730 non-motile cilium", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P83858-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84889-1", "uniprot_id": [ { "id": "VANG2_RAT", "url": "https://www.uniprot.org/uniprot/P84889", "type": "external" } ], "mass": 59771.0, "length": 521, "protein_name": "Vang-like protein 2", "gene_name": "Vangl2", "organism": "Rat", "refseq_name": "vang-like protein 2", "refseq_ac": [ { "id": "NP_001099439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099439", "type": "external" } ], "gene_names_uniprotkb": "Vangl2", "gene_names_refseq": "Ltap; Vangl2", "protein_names_uniprotkb": "Vang-like protein 2; Van Gogh-like protein 2", "protein_names_refseq": "loop tail associated protein; van Gogh-like protein 2; vang-like 2 (van gogh, Drosophila); vang-like protein 2", "tax_id": 10116, "disease": "ciliopathy (Disease Ontology:DOID:0060340); neural tube defect (Disease Ontology:DOID:0080074)", "pathway": " (rno:289229); (R-RNO-9696264); (R-RNO-9696270); (R-RNO-9696273)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "16687519;26257100;26683906;26990065;29454802;29497043", "class_list": "", "function": "In summary, the PCP protein Vangl2 is an ectoplasmic specialisation regulator through its effects on actin microfilaments in the testis., [RefSeq, PubMed]; Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity)., [UniProtKB, UniProtKB]; Spermatid planar cell polarity was regulated by Vangl2. Publication Status: Online-Only, [RefSeq, PubMed]; The synaptic localisation of Vangl2 was categorised into two types: overlapping co-localisation with postsynaptic density (PSD)-95 or highly correlated but complementary pattern of association with PSD-95. Publication Status: Online-Only, [RefSeq, PubMed]; Vangl2 plays a role in the establishment and/or maintenance of the postsynaptic compartments., [RefSeq, PubMed]; Wnt/JNK activation induced cytoskeleton rearrangement but failed to activate these effects in cells lacking Vangl2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "GO:0060993 kidney morphogenesis;GO:0032956 regulation of actin cytoskeleton organization;GO:0007266 Rho protein signal transduction;GO:0001843 neural tube closure;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P84889-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85973-1", "uniprot_id": [ { "id": "PNPH_RAT", "url": "https://www.uniprot.org/uniprot/P85973", "type": "external" } ], "mass": 32302.0, "length": 289, "protein_name": "Purine nucleoside phosphorylase", "gene_name": "Pnp", "organism": "Rat", "refseq_name": "purine nucleoside phosphorylase", "refseq_ac": [ { "id": "NP_001386607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386607", "type": "external" } ], "gene_names_uniprotkb": "Pnp; Np", "gene_names_refseq": "Np; Pnp", "protein_names_uniprotkb": "Purine nucleoside phosphorylase; 2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylase; PNP", "protein_names_refseq": "inosine phosphorylase; inosine-guanosine phosphorylase; nucleoside phosphorylase; purine nucleoside phosphorylase", "tax_id": 10116, "disease": "purine nucleoside phosphorylase deficiency (Disease Ontology:DOID:5813); purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)", "pathway": " (rno:290029); (R-RNO-6798695); (R-RNO-74217); (R-RNO-74259); (R-RNO-9755088)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "19343716;32910805;34502162", "class_list": "", "function": "Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6KEC5", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0042802 identical protein binding;GO:0001882 nucleoside binding;GO:0002060 purine nucleobase binding;GO:0004731 purine-nucleoside phosphorylase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006955 immune response;GO:0043101 purine-containing compound salvage;GO:0006157 deoxyadenosine catabolic process;GO:0046638 positive regulation of alpha-beta T cell differentiation;GO:0042102 positive regulation of T cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P85973-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86091-1", "uniprot_id": [ { "id": "TMPS7_RAT", "url": "https://www.uniprot.org/uniprot/P86091", "type": "external" } ], "mass": 93286.0, "length": 833, "protein_name": "Transmembrane protease serine 7", "gene_name": "Tmprss7", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmprss7", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protease serine 7; 3.4.21.-; Matriptase-3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:288118)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P86091-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P86252-1", "uniprot_id": [ { "id": "PURA_RAT", "url": "https://www.uniprot.org/uniprot/P86252", "type": "external" } ], "mass": 15322.0, "length": 138, "protein_name": "Transcriptional activator protein Pur-alpha", "gene_name": "Pura", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pura", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcriptional activator protein Pur-alpha; Purine-rich single-stranded DNA-binding protein alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant intellectual developmental disorder 31 (Disease Ontology:DOID:0070061)", "pathway": " (rno:102557111)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;38843836", "class_list": "", "function": "This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the c-Myc gene. May play a role in the initiation of DNA replication and in recombination (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0030425 dendrite", "go_biological_process": "GO:0098963 dendritic transport of messenger ribonucleoprotein complex;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P86252-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97524-1", "uniprot_id": [ { "id": "S27A2_RAT", "url": "https://www.uniprot.org/uniprot/P97524", "type": "external" } ], "mass": 70694.0, "length": 620, "protein_name": "Long-chain fatty acid transport protein 2", "gene_name": "Slc27a2", "organism": "Rat", "refseq_name": "long-chain fatty acid transport protein 2", "refseq_ac": [ { "id": "NP_113924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113924", "type": "external" } ], "gene_names_uniprotkb": "Slc27a2; Acsvl1; Facvl1; Fatp2; Vlacs; Vlcs", "gene_names_refseq": "Slc27a2", "protein_names_uniprotkb": "Long-chain fatty acid transport protein 2; 6.2.1.-; 6.2.1.15; 6.2.1.24; 6.2.1.3; 6.2.1.7; Arachidonate--CoA ligase; FATP-2; Fatty acid transport protein 2; Fatty-acid-coenzyme A ligase, very long-chain 1; Long-chain-fatty-acid--CoA ligase; Phytanate--CoA ligase; Solute carrier family 27 member 2; THCA-CoA ligase; VLACS; VLCS; Very long-chain acyl-CoA synthetase; Very long-chain-fatty-acid-CoA ligase", "protein_names_refseq": "FATP-2; THCA-CoA ligase; VLACS; VLCS; arachidonate--CoA ligase; fatty acid transport protein 2; fatty-acid-coenzyme A ligase, very long-chain 1; long-chain fatty acid transport protein 2; long-chain-fatty-acid--CoA ligase; phytanate--CoA ligase; solute carrier family 27 (fatty acid transporter), member 2; solute carrier family 27 (fatty acid transporter), member 32; very long-chain acyl-CoA synthetase; very long-chain-fatty-acid-CoA ligase", "tax_id": 10116, "disease": "", "pathway": " (rno:65192); (R-RNO-193368); (R-RNO-193775); (R-RNO-389599); (R-RNO-390247); (R-RNO-6798695); (R-RNO-75105); (R-RNO-9033241)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "10640429;28993506;8939997", "class_list": "", "function": "Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (By similarity). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:10640429, PubMed:8939997). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:10640429, PubMed:8939997). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (By similarity). May contribute to the synthesis of sphingosine-1-phosphate (By similarity). Does not activate C24 bile acids, cholate and chenodeoxycholate. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. However, it is not critical for THCA activation and bile synthesis in vivo (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; We conclude that FATP2 is a major apical proximal tubule NEFA transporter that regulates lipoapoptosis and may be an amenable target for the prevention of CKD progression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0015245 fatty acid transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0004467 long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005886 plasma membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0006699 bile acid biosynthetic process;GO:0042760 very long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P97524-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02353-1", "uniprot_id": [ { "id": "NDST1_RAT", "url": "https://www.uniprot.org/uniprot/Q02353", "type": "external" } ], "mass": 100785.0, "length": 882, "protein_name": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1", "gene_name": "Ndst1", "organism": "Rat", "refseq_name": "bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1", "refseq_ac": [ { "id": "NP_077337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077337", "type": "external" } ], "gene_names_uniprotkb": "Ndst1; Hsst1; Hsst", "gene_names_refseq": "Hsst; N-HSST; Ndst1", "protein_names_uniprotkb": "Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Glucosaminyl N-deacetylase/N-sulfotransferase 1; Golgi heparan sulfate N-deacetylase/N-sulfotransferase; HSNST 1; N-HSST 1; N-HSST; N-heparan sulfate sulfotransferase 1; NDST-1; [Heparan sulfate]-glucosamine N-sulfotransferase 1", "protein_names_refseq": "Golgi heparan sulfate N-deacetylase/N-sulfotransferase; HSNST 1; N-HSST 1; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; N-heparan sulfate sulfotransferase 1; NDST-1; [Heparan sulfate]-glucosamine N-sulfotransferase 1; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; glucosaminyl N-deacetylase/N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder 46 (Disease Ontology:DOID:0081210); intellectual disability (Disease Ontology:DOID:1059); DiGeorge syndrome (Disease Ontology:DOID:11198); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); azoospermia (Disease Ontology:DOID:14227); germ cell cancer (Disease Ontology:DOID:2994); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (rno:29633); (R-RNO-2022928)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "11792394;1379236;21454625;28363469;3422231;36222339;8483907;9890952", "class_list": "", "function": "Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:1379236, PubMed:3422231, PubMed:8483907, PubMed:9890952). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (PubMed:1379236, PubMed:3422231). Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Relative mRNA expression of Ndst1 and Slit3 was significantly decreased in pleuroperitoneal folds, developing diaphragms and fully muscularized diaphragms, and endothelial cells within the diaphragmatic vasculature of nitrofen-exposed fetuses compared to controls., [RefSeq, PubMed]; The regulating role of NDST-1 in mapping the sulfation patterns of HS., [RefSeq, PubMed]; The role and mechanism of NDST1/NULP1 regulating right ventricular hypertrophy in hypoxic pulmonary hypertension., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "2.8.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.8", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0019213 deacetylase activity;GO:0015016 heparan sulfate N-sulfotransferase activity;GO:0050119 N-acetylglucosamine deacetylase activity;GO:0102140 heparan sulfate N-deacetylase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0006477 protein sulfation;GO:0045880 positive regulation of smoothened signaling pathway;GO:0000271 polysaccharide biosynthetic process;GO:0006954 inflammatory response;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q02353-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04462-1", "uniprot_id": [ { "id": "SYVC_RAT", "url": "https://www.uniprot.org/uniprot/Q04462", "type": "external" } ], "mass": 140368.0, "length": 1264, "protein_name": "Valine--tRNA ligase", "gene_name": "Vars1", "organism": "Rat", "refseq_name": "valine--tRNA ligase", "refseq_ac": [ { "id": "NP_445744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445744", "type": "external" } ], "gene_names_uniprotkb": "Vars1; Vars2; Vars", "gene_names_refseq": "Bat6; G7a; TrsVal; Vars1; Vars2; Vars", "protein_names_uniprotkb": "Valine--tRNA ligase; 6.1.1.9; ValRS; Valyl-tRNA synthetase", "protein_names_refseq": "valRS; valine--tRNA ligase; valyl-tRNA synthetase 2", "tax_id": 10116, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); combined oxidative phosphorylation deficiency 20 (Disease Ontology:DOID:0111478); mitochondrial metabolism disease (Disease Ontology:DOID:700); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (rno:25009)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060004;8428657", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6MG65", "ec_number_list": [ { "id": "6.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004832 valine-tRNA ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006438 valyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q04462-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04940-1", "uniprot_id": [ { "id": "NEUG_RAT", "url": "https://www.uniprot.org/uniprot/Q04940", "type": "external" } ], "mass": 7496.0, "length": 78, "protein_name": "Neurogranin", "gene_name": "Nrgn", "organism": "Rat", "refseq_name": "neurogranin", "refseq_ac": [ { "id": "NP_077054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077054", "type": "external" } ], "gene_names_uniprotkb": "Nrgn", "gene_names_refseq": "BICKS; Nrgn; RC3", "protein_names_uniprotkb": "Neurogranin; Ng; Protein kinase C substrate 7.5 kDa protein; RC3", "protein_names_refseq": "neurogranin (protein kinase C substrate, RC3); neurogranin; ng; protein kinase C substrate 7.5 kDa protein", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (rno:64356)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "15262982;1528865;19164277;2231781;26084473;31020616;31691647;35678097;38376763;7730337;8080473;8454596;8910523", "class_list": "", "function": "Low androgen level impairs erectile function of rat by regulating the Ng/CaN/AKT/eNOS pathway in penile corpus cavernosum., [RefSeq, PubMed]; Neurogranin Protein Expression Is Reduced after Controlled Cortical Impact in Rats., [RefSeq, PubMed]; Ng expression is regulated by synaptic activity and that Ng promotes the synaptogenesis process., [RefSeq, PubMed]; Regulates the affinity of calmodulin for calcium. Involved in synaptic plasticity and spatial learning (By similarity)., [UniProtKB, PubMed]; Temporal-Specific Sex and Injury-Dependent Changes on Neurogranin-Associated Synaptic Signaling After Controlled Cortical Impact in Rats., [RefSeq, PubMed]; These data indicate that Ng-mediated enhancement of synaptic strength is due to its ability to target, rather than sequester, CaM within dendritic spines. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0070300 phosphatidic acid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0012510 trans-Golgi network transport vesicle membrane;GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0008306 associative learning;GO:1900273 positive regulation of long-term synaptic potentiation;GO:0021537 telencephalon development;GO:0099170 postsynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q04940-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05030-1", "uniprot_id": [ { "id": "PGFRB_RAT", "url": "https://www.uniprot.org/uniprot/Q05030", "type": "external" } ], "mass": 122828.0, "length": 1097, "protein_name": "Platelet-derived growth factor receptor beta", "gene_name": "Pdgfrb", "organism": "Rat", "refseq_name": "platelet-derived growth factor receptor beta precursor", "refseq_ac": [ { "id": "NP_113713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113713", "type": "external" } ], "gene_names_uniprotkb": "Pdgfrb; Pdgfr1; Pdgfr", "gene_names_refseq": "PDGFR-1; Pdgfrb", "protein_names_uniprotkb": "Platelet-derived growth factor receptor beta; 2.7.10.1; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1", "protein_names_refseq": "CD140 antigen-like family member B; PDGF-R-beta; PDGFR-beta; Platelet-derived growth factor receptor, beta; beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; platelet derived growth factor receptor, beta polypeptide; platelet-derived growth factor receptor 1; platelet-derived growth factor receptor beta precursor", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); basal ganglia calcification (Disease Ontology:DOID:0060230); infantile myofibromatosis 1 (Disease Ontology:DOID:0070666); infantile myofibromatosis (Disease Ontology:DOID:0080109); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sciatic neuropathy (Disease Ontology:DOID:11446); oligohydramnios (Disease Ontology:DOID:12215); extrahepatic cholestasis (Disease Ontology:DOID:13619); major depressive disorder (Disease Ontology:DOID:1470); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); myeloproliferative neoplasm (Disease Ontology:DOID:2226); Leydig cell tumor (Disease Ontology:DOID:2696); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); breast carcinoma (Disease Ontology:DOID:3459); middle cerebral artery infarction (Disease Ontology:DOID:3525); choriocarcinoma (Disease Ontology:DOID:3594); renal cell carcinoma (Disease Ontology:DOID:4450); schizophrenia (Disease Ontology:DOID:5419); nephrolithiasis (Disease Ontology:DOID:585); severe nonproliferative diabetic retinopathy (Disease Ontology:DOID:8946)", "pathway": " (rno:24629); (R-RNO-1257604); (R-RNO-186763); (R-RNO-186797); (R-RNO-5673001); (R-RNO-6811558)", "pathway_count": 6, "publication_count": 8, "publication_id_list": "11346654;16569213;34534604;35848503;36591929;37121121;38338969;8318539", "class_list": "", "function": "Cardiac microvascular functions improved by MSC-derived exosomes attenuate cardiac fibrosis after ischemia-reperfusion via PDGFR-beta modulation., [RefSeq, PubMed]; In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRbeta, and Collagen IV in Endothelial Cells and Pericytes of the Blood-Brain Barrier. Publication Status: Online-Only, [RefSeq, PubMed]; Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCgamma1 axis., [RefSeq, PubMed]; PDGF-beta and IL-18 Expressions on Carcinoma Cervical by Rhodomyrtus tomentosa., [RefSeq, PubMed]; PDGFRB upregulation contributes to retinal damages in the rat model of retinal ischemia-reperfusion., [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity)., [UniProtKB]; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 11, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q8R406;Q925F7", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0004672 protein kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005096 GTPase activator activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0072223 metanephric glomerular mesangium development;GO:2000491 positive regulation of hepatic stellate cell activation;GO:0001525 angiogenesis;GO:0001701 in utero embryonic development;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q05030-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05343-1", "uniprot_id": [ { "id": "RXRA_RAT", "url": "https://www.uniprot.org/uniprot/Q05343", "type": "external" } ], "mass": 51266.0, "length": 467, "protein_name": "Retinoic acid receptor RXR-alpha", "gene_name": "Rxra", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rxra; Nr2b1", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoic acid receptor RXR-alpha; Nuclear receptor subfamily 2 group B member 1; Retinoid X receptor alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); congenital heart disease (Disease Ontology:DOID:1682); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); prostate carcinoma in situ (Disease Ontology:DOID:8634); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:25271); (R-RNO-159418); (R-RNO-192105); (R-RNO-193368); (R-RNO-193807); (R-RNO-200425); (R-RNO-211976); (R-RNO-381340); (R-RNO-383280); (R-RNO-400206); (R-RNO-4090294); (R-RNO-5362517); (R-RNO-9029569); (R-RNO-9616222); (R-RNO-9623433); (R-RNO-9707564); (R-RNO-9841922)", "pathway_count": 17, "publication_count": 4, "publication_id_list": "22673903;28167758;28267642;8381967", "class_list": "", "function": "Receptor for retinoic acid that acts as a transcription factor (By similarity). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (By similarity). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (By similarity). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (By similarity). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (By similarity). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (By similarity). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (By similarity). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (By similarity). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:8381967). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (By similarity). Acts as an enhancer of RARA binding to RARE DNA element (By similarity). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (By similarity). Promotes myelin debris phagocytosis and remyelination by macrophages (By similarity). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (By similarity). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (By similarity)., [UniProtKB, PubMed, UniProtKB]; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050693 LBD domain binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0030424 axon;GO:0043235 receptor complex", "go_biological_process": "GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001701 in utero embryonic development;GO:0001889 liver development;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q05343-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07258-1", "uniprot_id": [ { "id": "TGFB3_RAT", "url": "https://www.uniprot.org/uniprot/Q07258", "type": "external" } ], "mass": 47116.0, "length": 412, "protein_name": "Transforming growth factor beta-3 proprotein", "gene_name": "Tgfb3", "organism": "Rat", "refseq_name": "transforming growth factor beta-3 proprotein preproprotein", "refseq_ac": [ { "id": "NP_037306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037306", "type": "external" } ], "gene_names_uniprotkb": "Tgfb3; Tgf-b3", "gene_names_refseq": "TGF-B3; Tgfb3", "protein_names_uniprotkb": "Transforming growth factor beta-3 proprotein", "protein_names_refseq": "TGF-beta-3; transforming growth factor beta-3 proprotein preproprotein; transforming growth factor beta-3 proprotein", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); Loeys-Dietz syndrome 5 (Disease Ontology:DOID:0070236); arrhythmogenic right ventricular dysplasia 1 (Disease Ontology:DOID:0110070); colon cancer (Disease Ontology:DOID:219); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); colorectal cancer (Disease Ontology:DOID:9256); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (rno:25717); (R-RNO-114608); (R-RNO-2129379); (R-RNO-2173789)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "26858265;31176490;34592976;34696976;35028925;37904673;7852342;8509457", "class_list": "", "function": "Down-regulation of miR-140-3p can inhibit painful tactile stimulation of rat pups by inhibiting TGF-beta, [RefSeq, PubMed]; GMFB/AKT/TGF-beta3 in Muller cells mediated early retinal degeneration in a streptozotocin-induced rat diabetes model., [RefSeq, PubMed]; Gait analysis combined with the expression of TGF-beta1, TGF-beta3 and CREB during Achilles tendon healing in rat., [RefSeq, PubMed]; Maternal Perinatal Exposure to Dibutyl Phthalate Promotes Ovarian Dysfunction in Adult Female Offspring via Downregulation of TGF-beta2 and TGF-beta3., [RefSeq, PubMed]; Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TGF-beta3 regulates adhesion formation through the JNK/c-Jun pathway during flexor tendon healing. Publication Status: Online-Only, [RefSeq, PubMed]; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q56A31", "ec_number_list": [], "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity;GO:0005160 transforming growth factor beta receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030141 secretory granule;GO:0031012 extracellular matrix;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050678 regulation of epithelial cell proliferation;GO:0060364 frontal suture morphogenesis;GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q07258-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07782-1", "uniprot_id": [ { "id": "S13A1_RAT", "url": "https://www.uniprot.org/uniprot/Q07782", "type": "external" } ], "mass": 66059.0, "length": 595, "protein_name": "Solute carrier family 13 member 1", "gene_name": "Slc13a1", "organism": "Rat", "refseq_name": "solute carrier family 13 member 1", "refseq_ac": [ { "id": "NP_113839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113839", "type": "external" } ], "gene_names_uniprotkb": "Slc13a1; Nas1; Nasi1", "gene_names_refseq": "Slc13a1", "protein_names_uniprotkb": "Solute carrier family 13 member 1; Na(+)/sulfate cotransporter; NaSi-1; Renal sodium/sulfate cotransporter", "protein_names_refseq": "Na(+)/sulfate cotransporter; naSi-1; renal sodium/sulfate cotransporter; solute carrier family 13 (sodium/sulfate symporter), member 1; solute carrier family 13 (sodium/sulfate symporters), member 1; solute carrier family 13 (sodium/sulphate symporters), member 1; solute carrier family 13 member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:58980); (R-RNO-433137)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "17681482;7690140;7816544;8175644;8300634;8765995", "class_list": "", "function": "Data demonstrate that NaSi-1 forms a dimeric protein which is glycosylated at N591, whose sorting to the apical membrane in renal epithelial cells is brefeldin A-sensitive and independent of lipid rafts or glycosylation., [RefSeq, PubMed]; Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine (PubMed:7690140, PubMed:7816544, PubMed:8175644, PubMed:8300634). Can also mediate the transport of selenate and thiosulfate (PubMed:8175644, PubMed:8300634)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015382 sodium:sulfate symporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015373 monoatomic anion:sodium symporter activity;GO:0015370 solute:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006814 sodium ion transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q07782-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2A865-1", "uniprot_id": [ { "id": "S6A19_RAT", "url": "https://www.uniprot.org/uniprot/Q2A865", "type": "external" } ], "mass": 71232.0, "length": 634, "protein_name": "Sodium-dependent neutral amino acid transporter B(0)AT1", "gene_name": "Slc6a19", "organism": "Rat", "refseq_name": "sodium-dependent neutral amino acid transporter B(0)AT1", "refseq_ac": [ { "id": "NP_001034811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034811", "type": "external" } ], "gene_names_uniprotkb": "Slc6a19; B0at1", "gene_names_refseq": "B0at1; Slc6a19", "protein_names_uniprotkb": "Sodium-dependent neutral amino acid transporter B(0)AT1; Solute carrier family 6 member 19; System B(0) neutral amino acid transporter AT1", "protein_names_refseq": "b(0)AT1; neutral amino acid transporter; sodium-dependent neutral amino acid transporter B(0)AT1; solute carrier family 6 (neurotransmitter transporter), member 19; solute carrier family 6 (neutral amino acid transporter), member 19; system B(0) neutral amino acid transporter AT1", "tax_id": 10116, "disease": "Hartnup disease (Disease Ontology:DOID:1060); hypertension (Disease Ontology:DOID:10763)", "pathway": " (rno:664630); (R-RNO-352230); (R-RNO-442660)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17264310;17646927;19556357;20448142;22673903;28915252", "class_list": "", "function": "Investigation of the chronic dietary regulation of B0AT1, ACE2 and CD13 by different diets revealed an increased B0AT1 protein expression under amino acid-supplemented diet in the proximal section but not in the distal one and for ACE2 protein expression a reverse localization of the effect. Publication Status: Online-Only, [RefSeq, PubMed]; Leptin controls active glutamine entry through reduction of both B(0)AT1 and ASCT2 protein trafficking to the apical plasma membrane and modulation of their gene expression., [RefSeq, PubMed]; Roux-en-Y gastric bypass selectively increased glutamine absorption in biliopancreatic and Roux limbs by a mechanism involving increased B(0)AT1 expression., [RefSeq, PubMed]; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A4ZVM8", "ec_number_list": [], "go_molecular_function": "GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:1902495 transmembrane transporter complex", "go_biological_process": "GO:0007584 response to nutrient;GO:0015804 neutral amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0089718 amino acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2A865-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ09-1", "uniprot_id": [ { "id": "UBP16_RAT", "url": "https://www.uniprot.org/uniprot/Q2KJ09", "type": "external" } ], "mass": 93762.0, "length": 826, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 16", "gene_name": "Usp16", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 16", "refseq_ac": [ { "id": "NP_001093971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093971", "type": "external" } ], "gene_names_uniprotkb": "Usp16", "gene_names_refseq": "Usp16", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 16; 3.4.19.12; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16", "protein_names_refseq": "deubiquitinating enzyme 16; ubiquitin carboxyl-terminal hydrolase 16; ubiquitin specific protease 16; ubiquitin thioesterase 16; ubiquitin thiolesterase 16; ubiquitin-specific-processing protease 16", "tax_id": 10116, "disease": "", "pathway": " (rno:288306); (R-RNO-5689880)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit. Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0043024 ribosomal small subunit binding;GO:0042393 histone binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KJ09-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ10-1", "uniprot_id": [ { "id": "RITA1_RAT", "url": "https://www.uniprot.org/uniprot/Q2KJ10", "type": "external" } ], "mass": 28148.0, "length": 258, "protein_name": "RBPJ-interacting and tubulin-associated protein 1", "gene_name": "Rita1", "organism": "Rat", "refseq_name": "RBPJ-interacting and tubulin-associated protein 1", "refseq_ac": [ { "id": "NP_001037691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037691", "type": "external" } ], "gene_names_uniprotkb": "Rita1; Rita", "gene_names_refseq": "RGD1306772; Rita1; Rita", "protein_names_uniprotkb": "RBPJ-interacting and tubulin-associated protein 1; RBPJ-interacting and tubulin-associated protein", "protein_names_refseq": "RBPJ-interacting and tubulin-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:288683)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0051168 nuclear export;GO:0022008 neurogenesis;GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJ10-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KMM2-1", "uniprot_id": [ { "id": "TPPC1_RAT", "url": "https://www.uniprot.org/uniprot/Q2KMM2", "type": "external" } ], "mass": 16882.0, "length": 145, "protein_name": "Trafficking protein particle complex subunit 1", "gene_name": "Trappc1", "organism": "Rat", "refseq_name": "trafficking protein particle complex subunit 1", "refseq_ac": [ { "id": "NP_001034467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034467", "type": "external" } ], "gene_names_uniprotkb": "Trappc1", "gene_names_refseq": "Trappc1", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 1", "protein_names_refseq": "trafficking protein particle complex 1; trafficking protein particle complex subunit 1", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162); melanoma (Disease Ontology:DOID:1909)", "pathway": " (rno:287427); (R-RNO-204005); (R-RNO-6798695); (R-RNO-8876198)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030008 TRAPP complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KMM2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2M1K6-1", "uniprot_id": [ { "id": "S39AD_RAT", "url": "https://www.uniprot.org/uniprot/Q2M1K6", "type": "external" } ], "mass": 38398.0, "length": 361, "protein_name": "Zinc transporter ZIP13", "gene_name": "Slc39a13", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc39a13; Zip13", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc transporter ZIP13; Solute carrier family 39 member 13; ZIP-13; Zrt- and Irt-like protein 13", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); Ehlers-Danlos syndrome spondylodysplastic type 3 (Disease Ontology:DOID:0080739); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359)", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol. May regulate beige adipocyte differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0046873 metal ion transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0010043 response to zinc ion;GO:0050873 brown fat cell differentiation;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2M1K6-1", "record_type": "protein", "filter_code": "0000000.0000010.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YDU8-1", "uniprot_id": [ { "id": "SPNS1_RAT", "url": "https://www.uniprot.org/uniprot/Q2YDU8", "type": "external" } ], "mass": 56796.0, "length": 528, "protein_name": "Protein spinster homolog 1", "gene_name": "Spns1", "organism": "Rat", "refseq_name": "protein spinster homolog 1", "refseq_ac": [ { "id": "NP_001034297", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034297", "type": "external" } ], "gene_names_uniprotkb": "Spns1", "gene_names_refseq": "RGD1305613; Spns1", "protein_names_uniprotkb": "Protein spinster homolog 1; RSpin1; Spns1", "protein_names_refseq": "RSpin1; SPNS sphingolipid transporter 1; protein spinster homolog 1; spinster homolog 1", "tax_id": 10116, "disease": "neuronal ceroid lipofuscinosis (Disease Ontology:DOID:14503); sphingolipidosis (Disease Ontology:DOID:1927)", "pathway": " (rno:361648)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21518918", "class_list": "", "function": "Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol. Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyltransferases in the endoplasmic reticulum to form phospholipids. Selective for zwitterionic headgroups such as lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), can also transport lysophosphatidylglycerol (LPG), but not other anionic lysophospholipids, sphingosine, nor sphingomyelin. Transports lysophospholipids with saturated, monounsaturated, and polyunsaturated fatty acids, such as 1-hexadecanoyl-sn-glycero-3-phosphocholine, 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine, respectively. Can also transport lysoplasmalogen (LPC with a fatty alcohol) such as 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine. Essential player in lysosomal homeostasis. Crucial for cell survival under conditions of nutrient limitation. May be involved in necrotic or autophagic cell death., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051978 lysophospholipid:sodium symporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0051977 lysophospholipid transport;GO:0033700 phospholipid efflux;GO:0035751 regulation of lysosomal lumen pH;GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2YDU8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3B7D3-1", "uniprot_id": [ { "id": "TECT2_RAT", "url": "https://www.uniprot.org/uniprot/Q3B7D3", "type": "external" } ], "mass": 77301.0, "length": 700, "protein_name": "Tectonic-2", "gene_name": "Dnah10; Tctn2", "organism": "Rat", "refseq_name": "tectonic-2 precursor", "refseq_ac": [ { "id": "NP_001074251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074251", "type": "external" } ], "gene_names_uniprotkb": "Dnah10; Tctn2; Tctn2; Tect2", "gene_names_refseq": "Tctn2; Tect2", "protein_names_uniprotkb": "Tectonic-2", "protein_names_refseq": "tectonic-2 precursor; tectonic-2", "tax_id": 10116, "disease": "Meckel syndrome 8 (Disease Ontology:DOID:0070122); Joubert syndrome 24 (Disease Ontology:DOID:0110993); spermatogenic failure 56 (Disease Ontology:DOID:0112336)", "pathway": " (rno:689779); (R-RNO-5620912)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;34623606", "class_list": "", "function": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity)., [UniProtKB]; Exosomes Derived from lncRNA TCTN2-Modified Mesenchymal Stem Cells Improve Spinal Cord Injury by miR-329-3p/IGF1R Axis., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0016020 membrane;GO:0036038 MKS complex;GO:0035869 ciliary transition zone;GO:0005874 microtubule;GO:0005930 axoneme", "go_biological_process": "GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:1904491 protein localization to ciliary transition zone;GO:0030030 cell projection organization;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3B7D3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3KR66-1", "uniprot_id": [ { "id": "PSRC1_RAT", "url": "https://www.uniprot.org/uniprot/Q3KR66", "type": "external" } ], "mass": 34577.0, "length": 329, "protein_name": "Proline/serine-rich coiled-coil protein 1", "gene_name": "Psrc1", "organism": "Rat", "refseq_name": "proline/serine-rich coiled-coil protein 1", "refseq_ac": [ { "id": "NP_001037767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037767", "type": "external" } ], "gene_names_uniprotkb": "Psrc1; Dda3", "gene_names_refseq": "Psrc1", "protein_names_uniprotkb": "Proline/serine-rich coiled-coil protein 1", "protein_names_refseq": "proline/serine-rich coiled-coil 1; proline/serine-rich coiled-coil protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:691380)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "34115425", "class_list": "", "function": "Loc680254 regulates Schwann cell proliferation through Psrc1 and Ska1 as a microRNA sponge following sciatic nerve injury., [RefSeq, PubMed]; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0051301 cell division;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth;GO:0007080 mitotic metaphase chromosome alignment;GO:0031116 positive regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3KR66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1H8-1", "uniprot_id": [ { "id": "TMM79_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1H8", "type": "external" } ], "mass": 43363.0, "length": 391, "protein_name": "Transmembrane protein 79", "gene_name": "Tmem79", "organism": "Rat", "refseq_name": "transmembrane protein 79", "refseq_ac": [ { "id": "NP_001029068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029068", "type": "external" } ], "gene_names_uniprotkb": "Tmem79", "gene_names_refseq": "RGD1309886; Tmem79", "protein_names_uniprotkb": "Transmembrane protein 79; Mattrin", "protein_names_refseq": "mattrin; transmembrane protein 79", "tax_id": 10116, "disease": "atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (rno:310626)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0042335 cuticle development;GO:0045055 regulated exocytosis;GO:0061436 establishment of skin barrier;GO:0031069 hair follicle morphogenesis;GO:0002070 epithelial cell maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3T1H8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T1J8-1", "uniprot_id": [ { "id": "RTF2_RAT", "url": "https://www.uniprot.org/uniprot/Q3T1J8", "type": "external" } ], "mass": 33812.0, "length": 306, "protein_name": "Replication termination factor 2", "gene_name": "Rtf2; Rtfdc1", "organism": "Rat", "refseq_name": "replication termination factor 2", "refseq_ac": [ { "id": "NP_001029062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029062", "type": "external" } ], "gene_names_uniprotkb": "Rtf2; Rtfdc1; Rtfdc1", "gene_names_refseq": "RGD1311072; Rtf2; Rtfdc1", "protein_names_uniprotkb": "Replication termination factor 2; RTF2; Replication termination factor 2 domain-containing protein 1", "protein_names_refseq": "UPF0549 protein C20orf43 homolog; protein RTF2 homolog; replication termination factor 2 domain containing 1; replication termination factor 2 domain-containing protein 1; replication termination factor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:296410)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005657 replication fork", "go_biological_process": "GO:0097752 regulation of DNA stability;GO:0072711 cellular response to hydroxyurea", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3T1J8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3ZAV1-1", "uniprot_id": [ { "id": "S22AC_RAT", "url": "https://www.uniprot.org/uniprot/Q3ZAV1", "type": "external" } ], "mass": 60245.0, "length": 553, "protein_name": "Solute carrier family 22 member 12", "gene_name": "Slc22a12", "organism": "Rat", "refseq_name": "solute carrier family 22 member 12", "refseq_ac": [ { "id": "NP_001030115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030115", "type": "external" } ], "gene_names_uniprotkb": "Slc22a12; Urat1", "gene_names_refseq": "Rst; Slc22a12; Slc22al2; URAT1", "protein_names_uniprotkb": "Solute carrier family 22 member 12; URAT1; Urate anion exchanger 1; Urate:anion antiporter SLC22A12", "protein_names_refseq": "solute carrier family 22 (organic anion/cation transporter), member 12; solute carrier family 22 (organic anion/urate transporter), member 12; solute carrier family 22 (organic cation transporter)-like 2; solute carrier family 22 member 12; urate anion exchanger 1; urate:anion antiporter SLC22A12", "tax_id": 10116, "disease": "diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (rno:365398); (R-RNO-561048)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21074513;25773064;28499081;28679589;33132325", "class_list": "", "function": "Data show that Urat1 (Slc22a12) is involved in uric acid reabsorption in rats in the same manner as URAT1 in humans, suggesting a useful model to study issues related to the role of human URAT1., [RefSeq, PubMed]; Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:21074513). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:21074513). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:21074513). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (By similarity). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent (By similarity)., [UniProtKB, PubMed, UniProtKB]; Insulin significantly increased URAT1 and decreased ABCG2 levels, resulting in increased kidney tubule uric acid reabsorption in streptozotocin-diabetic rats., [RefSeq, PubMed]; Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9., [RefSeq, PubMed]; Resveratrol reduced URAT1 mRNA expression under high uric acid levels, thereby reducing uric acid reabsorption in renal cells., [RefSeq, PubMed]; URAT1 lysosome degradation is affected by uric acid in uric acid nephropathy., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0015143 urate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0032869 cellular response to insulin stimulus;GO:0046415 urate metabolic process;GO:0015711 organic anion transport;GO:0009410 response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q3ZAV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498C8-1", "uniprot_id": [ { "id": "RER1_RAT", "url": "https://www.uniprot.org/uniprot/Q498C8", "type": "external" } ], "mass": 22988.0, "length": 196, "protein_name": "Protein RER1", "gene_name": "Rer1", "organism": "Rat", "refseq_name": "protein RER1", "refseq_ac": [ { "id": "NP_001034101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034101", "type": "external" } ], "gene_names_uniprotkb": "Rer1", "gene_names_refseq": "RGD1306324; Rer1", "protein_names_uniprotkb": "Protein RER1", "protein_names_refseq": "RER1 retention in endoplasmic reticulum 1 homolog; protein RER1", "tax_id": 10116, "disease": "", "pathway": " (rno:298675)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "Involved in the retention or retrieval of proteins localized in the endoplasmic reticulum from the early Golgi compartment, including the gamma-secretase complex subunit PEN-2 (PSENEN). Regulates intracellular trafficking of the gamma-secretase complex and amyloid-beta precursor protein (APP), thereby controlling APP levels at the cell surface and influencing the release of amyloid-beta peptides generated through gamma-secretase mediated processing of APP. During cerebral cortex and neural stem cell development, it is required to maintain sufficient expression and activity of gamma-secretase complex at the cell surface, modulating NOTCH processing and signaling (By similarity). In addition to its role in the control of protein trafficking, the RER1-dependent Golgi apparatus-endoplasmic reticulum retrieval system may regulate proteasomal degradation of alpha-synuclein (SNCA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033130 acetylcholine receptor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006621 protein retention in ER lumen;GO:0071340 skeletal muscle acetylcholine-gated channel clustering", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q498C8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498U3-1", "uniprot_id": [ { "id": "S2540_RAT", "url": "https://www.uniprot.org/uniprot/Q498U3", "type": "external" } ], "mass": 38061.0, "length": 337, "protein_name": "Mitochondrial glutathione transporter SLC25A40", "gene_name": "Slc25a40", "organism": "Rat", "refseq_name": "mitochondrial glutathione transporter SLC25A40", "refseq_ac": [ { "id": "NP_001380639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380639", "type": "external" } ], "gene_names_uniprotkb": "Slc25a40", "gene_names_refseq": "RGD1308774; Slc25a40", "protein_names_uniprotkb": "Mitochondrial glutathione transporter SLC25A40; Solute carrier family 25 member 40", "protein_names_refseq": "mitochondrial glutathione transporter SLC25A40; probable mitochondrial glutathione transporter SLC25A40", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:296813)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16949250", "class_list": "", "function": "Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Probable mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles (By similarity). Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034634 glutathione transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0048821 erythrocyte development;GO:1990542 mitochondrial transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q498U3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q498U4-1", "uniprot_id": [ { "id": "SARNP_RAT", "url": "https://www.uniprot.org/uniprot/Q498U4", "type": "external" } ], "mass": 23605.0, "length": 210, "protein_name": "SAP domain-containing ribonucleoprotein", "gene_name": "Sarnp", "organism": "Rat", "refseq_name": "SAP domain-containing ribonucleoprotein", "refseq_ac": [ { "id": "NP_001028242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028242", "type": "external" } ], "gene_names_uniprotkb": "Sarnp; Hcc1", "gene_names_refseq": "Cip29; RGD1305692; Sarnp", "protein_names_uniprotkb": "SAP domain-containing ribonucleoprotein; Nuclear protein Hcc-1", "protein_names_refseq": "SAP domain-containing ribonucleoprotein; cytokine induced protein 29 kDa; nuclear protein Hcc-1", "tax_id": 10116, "disease": "", "pathway": " (rno:362819); (R-RNO-159236)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000346 transcription export complex", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006406 mRNA export from nucleus;GO:0006417 regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q498U4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q499V8-1", "uniprot_id": [ { "id": "SARG_RAT", "url": "https://www.uniprot.org/uniprot/Q499V8", "type": "external" } ], "mass": 64612.0, "length": 604, "protein_name": "Specifically androgen-regulated gene protein", "gene_name": "Sarg", "organism": "Rat", "refseq_name": "specifically androgen-regulated gene protein isoform 1", "refseq_ac": [ { "id": "NP_001094258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094258", "type": "external" } ], "gene_names_uniprotkb": "Sarg", "gene_names_refseq": "C13h1orf116; Sarg", "protein_names_uniprotkb": "Specifically androgen-regulated gene protein", "protein_names_refseq": "specifically androgen-regulated gene protein isoform 1; specifically androgen-regulated gene protein", "tax_id": 10116, "disease": "", "pathway": " (rno:498222)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Putative androgen-specific receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q499V8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZT2-1", "uniprot_id": [ { "id": "PPME1_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZT2", "type": "external" } ], "mass": 42316.0, "length": 386, "protein_name": "Protein phosphatase methylesterase 1", "gene_name": "Ppme1", "organism": "Rat", "refseq_name": "protein phosphatase methylesterase 1", "refseq_ac": [ { "id": "NP_001178767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178767", "type": "external" } ], "gene_names_uniprotkb": "Ppme1; Pme1", "gene_names_refseq": "PME-1; Ppme1; RGD1309683", "protein_names_uniprotkb": "Protein phosphatase methylesterase 1; 3.1.1.89; PME-1", "protein_names_refseq": "protein phosphatase methylesterase 1", "tax_id": 10116, "disease": "", "pathway": " (rno:361613); (R-RNO-69273)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "17939993;25038454", "class_list": "", "function": "Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity)., [UniProtKB, PubMed]; Findings provide new insight into how CA may improve glucose homeostasis through enhancing peripheral glucose clearance in tissues such as skeletal muscle through a PME-1/PP2A/PKB signalling axis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.89", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019888 protein phosphatase regulator activity;GO:0051721 protein phosphatase 2A binding;GO:0019903 protein phosphatase binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4FZT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZT8-1", "uniprot_id": [ { "id": "SPRY4_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZT8", "type": "external" } ], "mass": 23250.0, "length": 207, "protein_name": "SPRY domain-containing protein 4", "gene_name": "Spryd4", "organism": "Rat", "refseq_name": "SPRY domain-containing protein 4", "refseq_ac": [ { "id": "NP_001032854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032854", "type": "external" } ], "gene_names_uniprotkb": "Spryd4", "gene_names_refseq": "RGD1306649; Spryd4", "protein_names_uniprotkb": "SPRY domain-containing protein 4", "protein_names_refseq": "SPRY domain-containing protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:288772)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4FZT8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4FZT9-1", "uniprot_id": [ { "id": "PSMD2_RAT", "url": "https://www.uniprot.org/uniprot/Q4FZT9", "type": "external" } ], "mass": 100188.0, "length": 908, "protein_name": "26S proteasome non-ATPase regulatory subunit 2", "gene_name": "Psmd2", "organism": "Rat", "refseq_name": "26S proteasome non-ATPase regulatory subunit 2", "refseq_ac": [ { "id": "NP_001026809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026809", "type": "external" } ], "gene_names_uniprotkb": "Psmd2", "gene_names_refseq": "Psmd2", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 2", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; proteasome 26S subunit, non-ATPase 2", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (rno:287984); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-6798695); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 57, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1., [UniProtKB, UniProtKB]; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0042176 regulation of protein catabolic process;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4FZT9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4G068-1", "uniprot_id": [ { "id": "T176A_RAT", "url": "https://www.uniprot.org/uniprot/Q4G068", "type": "external" } ], "mass": 26613.0, "length": 243, "protein_name": "Transmembrane protein 176A", "gene_name": "Tmem176a", "organism": "Rat", "refseq_name": "transmembrane protein 176A", "refseq_ac": [ { "id": "NP_001034097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034097", "type": "external" } ], "gene_names_uniprotkb": "Tmem176a", "gene_names_refseq": "0610011i04rik; RGD1310725; Tmem176a", "protein_names_uniprotkb": "Transmembrane protein 176A", "protein_names_refseq": "hepatocellular carcinoma-associated antigen 112; transmembrane protein 176A", "tax_id": 10116, "disease": "", "pathway": " (rno:297077)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:2001199 negative regulation of dendritic cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4G068-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLH4-1", "uniprot_id": [ { "id": "PSPC1_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLH4", "type": "external" } ], "mass": 58760.0, "length": 522, "protein_name": "Paraspeckle component 1", "gene_name": "Pspc1", "organism": "Rat", "refseq_name": "paraspeckle component 1", "refseq_ac": [ { "id": "NP_001020843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020843", "type": "external" } ], "gene_names_uniprotkb": "Pspc1", "gene_names_refseq": "Pspc1", "protein_names_uniprotkb": "Paraspeckle component 1", "protein_names_refseq": "paraspeckle component 1; paraspeckle protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:305910)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "RNA-binding protein required for the formation of nuclear paraspeckles (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (By similarity). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4KLH4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLJ8-1", "uniprot_id": [ { "id": "PDCL3_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLJ8", "type": "external" } ], "mass": 27699.0, "length": 240, "protein_name": "Phosducin-like protein 3", "gene_name": "Pdcl3", "organism": "Rat", "refseq_name": "phosducin-like protein 3", "refseq_ac": [ { "id": "NP_001020880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020880", "type": "external" } ], "gene_names_uniprotkb": "Pdcl3", "gene_names_refseq": "Pdcl3", "protein_names_uniprotkb": "Phosducin-like protein 3", "protein_names_refseq": "phosducin-like protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:316348)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;27496612", "class_list": "", "function": "Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (By similarity). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (PubMed:27496612). Modulates the activation of caspases during apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results have shown that PhLP2A interacts with Hsp90 and exhibits molecular chaperone activity toward denatured proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043184 vascular endothelial growth factor receptor 2 binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0010628 positive regulation of gene expression;GO:0006915 apoptotic process;GO:0034605 cellular response to heat;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q4KLJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KLZ1-1", "uniprot_id": [ { "id": "TM186_RAT", "url": "https://www.uniprot.org/uniprot/Q4KLZ1", "type": "external" } ], "mass": 24641.0, "length": 216, "protein_name": "Transmembrane protein 186", "gene_name": "Tmem186", "organism": "Rat", "refseq_name": "transmembrane protein 186", "refseq_ac": [ { "id": "NP_001020927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020927", "type": "external" } ], "gene_names_uniprotkb": "Tmem186", "gene_names_refseq": "Tmem186", "protein_names_uniprotkb": "Transmembrane protein 186", "protein_names_refseq": "transmembrane protein 186", "tax_id": 10116, "disease": "", "pathway": " (rno:497863); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0160295 mitochondrial complex I intermediate assembly complex", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4KLZ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QQT0-1", "uniprot_id": [ { "id": "RUSD4_RAT", "url": "https://www.uniprot.org/uniprot/Q4QQT0", "type": "external" } ], "mass": 42595.0, "length": 377, "protein_name": "Pseudouridylate synthase RPUSD4, mitochondrial", "gene_name": "Rpusd4", "organism": "Rat", "refseq_name": "pseudouridylate synthase RPUSD4, mitochondrial", "refseq_ac": [ { "id": "NP_001020455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020455", "type": "external" } ], "gene_names_uniprotkb": "Rpusd4", "gene_names_refseq": "RGD1311268; Rpusd4", "protein_names_uniprotkb": "Pseudouridylate synthase RPUSD4, mitochondrial; 5.4.99.-; RNA pseudouridylate synthase domain-containing protein 4", "protein_names_refseq": "RNA pseudouridylate synthase domain containing 4; RNA pseudouridylate synthase domain-containing protein 4; mitochondrial RNA pseudouridine synthase Rpusd4; pseudouridylate synthase RPUSD4, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:315550)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Acts on position 39 in mitochondrial tRNA(Phe). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.99.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.12", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0009982 pseudouridine synthase activity;GO:0106029 tRNA pseudouridine synthase activity;GO:1990400 mitochondrial ribosomal large subunit rRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0035770 ribonucleoprotein granule", "go_biological_process": "GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0031118 rRNA pseudouridine synthesis;GO:1990481 mRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4QQT0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V7E0-1", "uniprot_id": [ { "id": "TRMO_RAT", "url": "https://www.uniprot.org/uniprot/Q4V7E0", "type": "external" } ], "mass": 47595.0, "length": 431, "protein_name": "tRNA (adenine(37)-N6)-methyltransferase", "gene_name": "Trmo", "organism": "Rat", "refseq_name": "tRNA (adenine(37)-N6)-methyltransferase", "refseq_ac": [ { "id": "NP_001020823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020823", "type": "external" } ], "gene_names_uniprotkb": "Trmo", "gene_names_refseq": "Nap1; RGD1305420; Trmo", "protein_names_uniprotkb": "tRNA (adenine(37)-N6)-methyltransferase; 2.1.1.-; tRNA methyltransferase O", "protein_names_refseq": "nef-associated protein 1; tRNA (adenine(37)-N6)-methyltransferase; thioesterase NAP1", "tax_id": 10116, "disease": "", "pathway": " (rno:298072)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0089715 tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V7E0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V888-1", "uniprot_id": [ { "id": "PP4P2_RAT", "url": "https://www.uniprot.org/uniprot/Q4V888", "type": "external" } ], "mass": 28024.0, "length": 257, "protein_name": "Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "gene_name": "Pip4p2", "organism": "Rat", "refseq_name": "type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "refseq_ac": [ { "id": "NP_001020071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020071", "type": "external" } ], "gene_names_uniprotkb": "Pip4p2; Tmem55a", "gene_names_refseq": "Pip4p2; RGD1306225; Tmem55a", "protein_names_uniprotkb": "Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; 3.1.3.78; PtdIns-4,5-P2 4-Ptase II; Transmembrane protein 55A; Type 2 PtdIns-4,5-P2 4-Ptase", "protein_names_refseq": "ptdIns-4,5-P2 4-Ptase II; transmembrane protein 55A; type 2 PtdIns-4,5-P2 4-Ptase; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "tax_id": 10116, "disease": "", "pathway": " (rno:362490)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.78", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.78", "type": "external" } ], "go_molecular_function": "GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0050765 negative regulation of phagocytosis;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q4V888-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V899-1", "uniprot_id": [ { "id": "TM165_RAT", "url": "https://www.uniprot.org/uniprot/Q4V899", "type": "external" } ], "mass": 34810.0, "length": 323, "protein_name": "Putative divalent cation/proton antiporter TMEM165", "gene_name": "Tmem165", "organism": "Rat", "refseq_name": "putative divalent cation/proton antiporter TMEM165 precursor", "refseq_ac": [ { "id": "NP_001019973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019973", "type": "external" } ], "gene_names_uniprotkb": "Tmem165; Tparl", "gene_names_refseq": "Tmem165; Tparl", "protein_names_uniprotkb": "Putative divalent cation/proton antiporter TMEM165; Transmembrane protein 165; Transmembrane protein TPARL", "protein_names_refseq": "TPA regulated locus; putative divalent cation/proton antiporter TMEM165 precursor; putative divalent cation/proton antiporter TMEM165; transmembrane protein TPARL", "tax_id": 10116, "disease": "congenital disorder of glycosylation type II (Disease Ontology:DOID:0050571); congenital disorder of glycosylation type IIk (Disease Ontology:DOID:0070263)", "pathway": " (rno:364137)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (By similarity). The transport mechanism and stoichiometry remains to be elucidated (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0015085 calcium ion transmembrane transporter activity;GO:0005384 manganese ion transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0006487 protein N-linked glycosylation;GO:0070588 calcium ion transmembrane transport;GO:0006828 manganese ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V899-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V8B1-1", "uniprot_id": [ { "id": "S36A3_RAT", "url": "https://www.uniprot.org/uniprot/Q4V8B1", "type": "external" } ], "mass": 52850.0, "length": 477, "protein_name": "Proton-coupled amino acid transporter 3", "gene_name": "Slc36a3", "organism": "Rat", "refseq_name": "proton-coupled amino acid transporter 3", "refseq_ac": [ { "id": "NP_001019935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019935", "type": "external" } ], "gene_names_uniprotkb": "Slc36a3; Pat3; Tramd2", "gene_names_refseq": "Slc36a3", "protein_names_uniprotkb": "Proton-coupled amino acid transporter 3; Proton/amino acid transporter 3; Solute carrier family 36 member 3; Tramdorin-2", "protein_names_refseq": "proton-coupled amino acid transporter 3; proton/amino acid transporter 3; solute carrier family 36 (proton/amino acid symporter), member 3; tramdorin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:303148)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015180 L-alanine transmembrane transporter activity;GO:0015187 glycine transmembrane transporter activity;GO:0015193 L-proline transmembrane transporter activity;GO:0005280 amino acid:proton symporter activity", "go_cellular_component": "GO:0005774 vacuolar membrane", "go_biological_process": "GO:0015816 glycine transport;GO:0035524 proline transmembrane transport;GO:0015808 L-alanine transport;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q4V8B1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q52KK3-1", "uniprot_id": [ { "id": "S2551_RAT", "url": "https://www.uniprot.org/uniprot/Q52KK3", "type": "external" } ], "mass": 33774.0, "length": 298, "protein_name": "Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51", "gene_name": "Slc25a51", "organism": "Rat", "refseq_name": "mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51", "refseq_ac": [ { "id": "NP_001019956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019956", "type": "external" } ], "gene_names_uniprotkb": "Slc25a51; Mcart1", "gene_names_refseq": "Mcart1; Slc25a51", "protein_names_uniprotkb": "Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51; Mitochondrial NAD(+) transporter SLC25A51; Mitochondrial carrier triple repeat protein 1; Solute carrier family 25 member 51", "protein_names_refseq": "mitochondrial NAD(+) transporter SLC25A51; mitochondrial carrier triple repeat 1; mitochondrial carrier triple repeat protein 1; mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51", "tax_id": 10116, "disease": "", "pathway": " (rno:313241); (R-RNO-196807)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria. Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration. Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria. The transport mechanism, uniport or antiport, its electrogenicity and substrate selectivity, remain to be elucidated., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051724 NAD transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0019646 aerobic electron transport chain;GO:0034355 NAD+ biosynthetic process via the salvage pathway;GO:1990549 mitochondrial NAD transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q52KK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q53B90-1", "uniprot_id": [ { "id": "RAB43_RAT", "url": "https://www.uniprot.org/uniprot/Q53B90", "type": "external" } ], "mass": 23229.0, "length": 210, "protein_name": "Ras-related protein Rab-43", "gene_name": "Isy1; Rab43", "organism": "Rat", "refseq_name": "ras-related protein Rab-43", "refseq_ac": [ { "id": "NP_001019502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019502", "type": "external" } ], "gene_names_uniprotkb": "Isy1; Rab43; Rab43", "gene_names_refseq": "Rab43", "protein_names_uniprotkb": "Ras-related protein Rab-43; 3.6.5.2", "protein_names_refseq": "Ras-related protein RAB43; ras-related protein Rab-43", "tax_id": 10116, "disease": "", "pathway": " (rno:500249); (R-RNO-6811440); (R-RNO-8873719)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "24223996", "class_list": "", "function": "Exocytosis of Rab11- and L1-positive vesicles may play a central role in TC10-mediated neurite outgrowth Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Required for the structural integrity of the Golgi complex. Also controls the anterograde ER-to-Golgi transport of nascent G protein-coupled receptors (including ADRA2A, ADRA2B, ADRA2C, ADRA1B, ADRB2 and AGTR1) and regulates the ER sorting of GPCR members by virtue of its ability to interact directly. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0090382 phagosome maturation;GO:0000045 autophagosome assembly;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0071346 cellular response to type II interferon", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q53B90-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q561R7-1", "uniprot_id": [ { "id": "TF2H3_RAT", "url": "https://www.uniprot.org/uniprot/Q561R7", "type": "external" } ], "mass": 34278.0, "length": 309, "protein_name": "General transcription factor IIH subunit 3", "gene_name": "Gtf2h3", "organism": "Rat", "refseq_name": "general transcription factor IIH subunit 3", "refseq_ac": [ { "id": "NP_001019407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019407", "type": "external" } ], "gene_names_uniprotkb": "Gtf2h3", "gene_names_refseq": "Gtf2h3", "protein_names_uniprotkb": "General transcription factor IIH subunit 3; General transcription factor IIH polypeptide 3", "protein_names_refseq": "general transcription factor IIH subunit 3; general transcription factor IIH, polypeptide 3", "tax_id": 10116, "disease": "", "pathway": " (rno:288651); (R-RNO-112382); (R-RNO-113418); (R-RNO-5696395); (R-RNO-5696400); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-72086); (R-RNO-73762); (R-RNO-73772); (R-RNO-73776); (R-RNO-73779); (R-RNO-73863); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-77075)", "pathway_count": 20, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005675 transcription factor TFIIH holo complex;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q561R7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q562C7-1", "uniprot_id": [ { "id": "PUM3_RAT", "url": "https://www.uniprot.org/uniprot/Q562C7", "type": "external" } ], "mass": 72786.0, "length": 647, "protein_name": "Pumilio homolog 3", "gene_name": "Pum3l1; Pum3", "organism": "Rat", "refseq_name": "pumilio homolog 3", "refseq_ac": [ { "id": "NP_001020207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020207", "type": "external" } ], "gene_names_uniprotkb": "Pum3l1; Pum3; Pum3l1; RGD1308750", "gene_names_refseq": "Pum3", "protein_names_uniprotkb": "Pumilio homolog 3", "protein_names_refseq": "pumilio homolog 3", "tax_id": 10116, "disease": "", "pathway": " (rno:294066); (rno:499339)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G054", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005694 chromosome", "go_biological_process": "GO:0006417 regulation of translation;GO:0010835 regulation of protein ADP-ribosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q562C7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q566C7-1", "uniprot_id": [ { "id": "NUDT3_RAT", "url": "https://www.uniprot.org/uniprot/Q566C7", "type": "external" } ], "mass": 19096.0, "length": 168, "protein_name": "Diphosphoinositol polyphosphate phosphohydrolase 1", "gene_name": "Nudt3", "organism": "Rat", "refseq_name": "diphosphoinositol polyphosphate phosphohydrolase 1", "refseq_ac": [ { "id": "NP_001019414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019414", "type": "external" } ], "gene_names_uniprotkb": "Nudt3; Dipp1; Dipp", "gene_names_refseq": "Nudt3", "protein_names_uniprotkb": "Diphosphoinositol polyphosphate phosphohydrolase 1; 3.6.1.10; 3.6.1.52; 3.6.1.59; 3.6.1.61; 3.6.1.62; Ap6A hydrolase; DIPP-1; Diadenosine hexaphosphate hydrolase; Endopolyphosphatase; Nucleoside diphosphate-linked moiety X motif 3; Nudix motif 3; m7GpppN-mRNA hydrolase; m7GpppX diphosphatase", "protein_names_refseq": "DIPP-1; ap6A hydrolase; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1; diadenosine hexaphosphate hydrolase; diphosphoinositol polyphosphate phosphohydrolase 1; endopolyphosphatase; m7GpppN-mRNA hydrolase; m7GpppX diphosphatase; nucleoside diphosphate-linked moiety X motif 3; nudix (nucleoside diphosphate linked moiety X)-type motif 3; nudix (nucleotide diphosphate linked moiety X)-type motif 3; nudix motif 3; nudix-type motif 3", "tax_id": 10116, "disease": "", "pathway": " (rno:294292); (R-RNO-1855167)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "34788624;9822604", "class_list": "", "function": "Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:9822604). InsP6 (inositol hexakisphosphate) is not a substrate (By similarity). Acts as a negative regulator of the ERK1/2 pathway (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates (By similarity). The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A (By similarity). Also able to hydrolyze 5- phosphoribose 1-diphosphate (By similarity). Acts as a decapping enzyme that can hydrolyze both monomethylated and unmethylated capped RNAs (By similarity). Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA (By similarity). Modulates the stability of a subset of mRNAs implicated in cell motility (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity (By similarity). Exhibits endopolyphosphatase activity in the presence of zinc ions (PubMed:34788624). Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions and diadenosine hexaphosphate hydrolase activity in the presence of manganese ions (By similarity). Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.64", "type": "external" }, { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.52", "type": "external" }, { "id": "3.6.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.10", "type": "external" }, { "id": "3.6.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.61", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0000298 endopolyphosphatase activity;GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity;GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity;GO:0052840 inositol diphosphate tetrakisphosphate diphosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0071543 diphosphoinositol polyphosphate metabolic process;GO:0071544 diphosphoinositol polyphosphate catabolic process;GO:1901907 diadenosine pentaphosphate catabolic process;GO:1901909 diadenosine hexaphosphate catabolic process;GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q566C7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q566R2-1", "uniprot_id": [ { "id": "TM2D2_RAT", "url": "https://www.uniprot.org/uniprot/Q566R2", "type": "external" } ], "mass": 22929.0, "length": 213, "protein_name": "TM2 domain-containing protein 2", "gene_name": "Tm2d2", "organism": "Rat", "refseq_name": "TM2 domain-containing protein 2 precursor", "refseq_ac": [ { "id": "NP_001017444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017444", "type": "external" } ], "gene_names_uniprotkb": "Tm2d2", "gene_names_refseq": "2410018g23rik; RGD1306769; Tm2d2", "protein_names_uniprotkb": "TM2 domain-containing protein 2", "protein_names_refseq": "BBP-like protein 1; TM2 domain-containing protein 2 precursor; TM2 domain-containing protein 2", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (rno:290833)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q566R2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJR4-1", "uniprot_id": [ { "id": "PRUN2_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJR4", "type": "external" } ], "mass": 36980.0, "length": 322, "protein_name": "Protein prune homolog 2", "gene_name": "Prune2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prune2; Bmcc1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein prune homolog 2; BNIP2 motif-containing molecule at the C-terminal region 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0098793 presynapse", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BJR4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZA5-1", "uniprot_id": [ { "id": "S4A10_RAT", "url": "https://www.uniprot.org/uniprot/Q80ZA5", "type": "external" } ], "mass": 125639.0, "length": 1117, "protein_name": "Sodium-driven chloride bicarbonate exchanger", "gene_name": "Slc4a10", "organism": "Rat", "refseq_name": "sodium-driven chloride bicarbonate exchanger isoform 4", "refseq_ac": [ { "id": "NP_835193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_835193", "type": "external" } ], "gene_names_uniprotkb": "Slc4a10; Ncbe", "gene_names_refseq": "NCBE; Slc4a10", "protein_names_uniprotkb": "Sodium-driven chloride bicarbonate exchanger; Solute carrier family 4 member 10", "protein_names_refseq": "Na+ bicarbonate transporter NBCn2-G; Na-bicarbonate cotransporter NBCn2-O; sodium-driven chloride bicarbonate exchanger isoform 4; sodium-driven chloride bicarbonate exchanger; solute carrier family 4, sodium bicarbonate transporter, member 10; solute carrier family 4, sodium bicarbonate transporter-like, member 10", "tax_id": 10116, "disease": "anemia (Disease Ontology:DOID:2355)", "pathway": " (rno:295645); (R-RNO-425381)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10993873;14592810;14656289;18061361;20566632;22673903;23409100;24223558;25003116;26192895;28280139;31736772;33109704", "class_list": "", "function": "A new promoter of Slc4a10 encoding NBCn2 and a novel type of Nterminus-truncated NBCn2, were identified. Publication Status: Online-Only, [RefSeq, PubMed]; SLC4A10 gene product and NBCn1 both function as basolateral HCO3- entry pathways and that the SLC4A10 gene product may be responsible for the stilbene-sensitive Na+-HCO3- uptake that is essential for cerebrospinal fluid production., [RefSeq, PubMed]; Sodium/bicarbonate cotransporter which mediates cotransport of sodium and bicarbonate in association with an efflux of intracellular chloride and is involved in NaCl absorption in the small intestine., [UniProtKB, PubMed]; Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:20566632, PubMed:23409100). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (PubMed:10993873, PubMed:20566632). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (PubMed:28280139)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; The study results allow concluding that Na(+) is not required for Cl(-) efflux via Cl(-)/HCO3 (-) exchanger., [RefSeq, PubMed]; We identify two novel variants of the sodium-driven chloride bicarbonate exchanger from brain. The developmental expression pattern seen by in situ hybridization reveals strong expression in spinal cord and brain beginning in embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JYF0;A0A2L1K0J5;D3ZGB5;D3ZY00;D4ADV4;J7FMV4;J7FPF5;J7FRI2;J7FTX0;Q6PU70;Q6PU71;Q6PU72;Q6PU73;Q6PU74;Q80ZA6", "ec_number_list": [], "go_molecular_function": "GO:0008510 sodium:bicarbonate symporter activity;GO:0140892 sodium,bicarbonate:chloride antiporter activity;GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0055085 transmembrane transport;GO:0035264 multicellular organism growth;GO:0007601 visual perception;GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q80ZA5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXW4-1", "uniprot_id": [ { "id": "PHF7_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXW4", "type": "external" } ], "mass": 43388.0, "length": 380, "protein_name": "E3 ubiquitin-protein ligase PHF7", "gene_name": "PHD finger protein 7; Phf7", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase PHF7", "refseq_ac": [ { "id": "NP_001012211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012211", "type": "external" } ], "gene_names_uniprotkb": "PHD finger protein 7; Phf7", "gene_names_refseq": "Phf7", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase PHF7; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase PHF7", "tax_id": 10116, "disease": "", "pathway": " (rno:364510)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which ubiquitinates histone H3 at 'Lys-14' (By similarity). Required for male fertility, via inhibition of SPOP-mediated BRDT degradation when in the presence of acetylated histone H4 in early condensing spermatids (By similarity). Stabilization of BRDT allows it to facilitate histone removal in early condensing spermatids and promote the progression of histone-to-protamine exchange (By similarity). Promotes the expression of steroidogenesis proteins in the testes, and as a result plays a role in maintaining testosterone levels and repressing osteoclastogenesis (By similarity). Promotes transcription of cardiac enhancer genes by facilitating binding of cardiac transcription factors such as MEF2C and GATA4 to target gene promoters (By similarity). Ubiquitinates histone H4 (By similarity). Ubiquitinates histone H2A and H3 as part of the nucleosome core particle (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; E3 ubiquitin-protein ligase which ubiquitinates histone H3 at 'Lys-14'. Required for male fertility, via inhibition of SPOP-mediated BRDT degradation when in the presence of acetylated histone H4 in early condensing spermatids. Stabilization of BRDT allows it to facilitate histone removal in early condensing spermatids and promote the progression of histone-to-protamine exchange. Promotes the expression of steroidogenesis proteins in the testes, and as a result plays a role in maintaining testosterone levels and repressing osteoclastogenesis. Promotes transcription of cardiac enhancer genes by facilitating binding of cardiac transcription factors such as MEF2C and GATA4 to target gene promoters. Ubiquitinates histone H4. Ubiquitinates histone H2A and H3 as part of the nucleosome core particle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140851 histone H3K14 ubiquitin ligase activity;GO:0016740 transferase activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0090291 negative regulation of osteoclast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXW4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q765A7-1", "uniprot_id": [ { "id": "PGAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q765A7", "type": "external" } ], "mass": 104384.0, "length": 922, "protein_name": "GPI inositol-deacylase", "gene_name": "Pgap1", "organism": "Rat", "refseq_name": "GPI inositol-deacylase", "refseq_ac": [ { "id": "NP_973719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_973719", "type": "external" } ], "gene_names_uniprotkb": "Pgap1", "gene_names_refseq": "Pgap1", "protein_names_uniprotkb": "GPI inositol-deacylase; 3.1.-.-; Post-GPI attachment to proteins factor 1", "protein_names_refseq": "GPI deacylase; GPI inositol-deacylase; Post GPI Attachment to Proteins 1; post-GPI attachment to proteins 1; post-GPI attachment to proteins factor 1", "tax_id": 10116, "disease": "holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (rno:316400); (R-RNO-162791)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "14734546;18683930;24090084;29393594;38843836", "class_list": "", "function": "GPI inositol-deacylase that catalyzes the remove of the acyl chain linked to the 2-OH position of inositol ring from the GPI-anchored protein (GPI-AP) in the endoplasmic reticulum (PubMed:14734546). Initiates the post-attachment remodeling phase of GPI-AP biogenesis and participates in endoplasmic reticulum (ER)-to-Golgi transport of GPI-anchored protein (PubMed:14734546)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 4, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 10, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0160215 deacylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007605 sensory perception of sound;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport;GO:0009948 anterior/posterior axis specification;GO:0060322 head development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q765A7-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0J8-1", "uniprot_id": [ { "id": "PH11L_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0J8", "type": "external" } ], "mass": 32566.0, "length": 293, "protein_name": "PHD finger protein 11-like", "gene_name": "LOC134482126; Phf11a; Phf11b; Phf11l", "organism": "Rat", "refseq_name": "PHD finger protein 11-like", "refseq_ac": [ { "id": "NP_001014257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014257", "type": "external" } ], "gene_names_uniprotkb": "LOC134482126; Phf11a; Phf11b; Phf11l; LOC108348241; Phf11a", "gene_names_refseq": "Phf11b; Phf11l", "protein_names_uniprotkb": "PHD finger protein 11-like", "protein_names_refseq": "PHD finger protein 11-like", "tax_id": 10116, "disease": "childhood-onset asthma (Disease Ontology:DOID:0080815); allergic disease (Disease Ontology:DOID:1205); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310)", "pathway": " (rno:108348241); (rno:364393)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0J8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TQ94-1", "uniprot_id": [ { "id": "NIT1_RAT", "url": "https://www.uniprot.org/uniprot/Q7TQ94", "type": "external" } ], "mass": 36094.0, "length": 327, "protein_name": "Deaminated glutathione amidase", "gene_name": "Nit1", "organism": "Rat", "refseq_name": "deaminated glutathione amidase isoform b", "refseq_ac": [ { "id": "NP_001076049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076049", "type": "external" } ], "gene_names_uniprotkb": "Nit1; rCG_20134", "gene_names_refseq": "Nit1", "protein_names_uniprotkb": "Deaminated glutathione amidase; 3.5.1.128; Nitrilase homolog 1; dGSH amidase", "protein_names_refseq": "dGSH amidase; deaminated glutathione amidase isoform b; deaminated glutathione amidase; nitrilase homolog 1", "tax_id": 10116, "disease": "brain small vessel disease 4 (Disease Ontology:DOID:0061234)", "pathway": " (rno:289222)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells., [UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the nitrilase enzyme superfamily. Nitrilases are nonpeptidic C-N hydrolases. In mammals, nitrilases form small molecule C-N bonds such as acid amides, carbamates and ureas. Nit1-deficient mice display phenotypes including increased cell proliferation, resistance to DNA damage, and an increased number of N-nitrosomethylbenzylamine-induced murine forestomach tumors, suggesting a tumor suppressor function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5PQK6", "ec_number_list": [ { "id": "3.5.1.128", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.128", "type": "external" } ], "go_molecular_function": "GO:0110050 deaminated glutathione amidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0043605 amide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TQ94-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY61-1", "uniprot_id": [ { "id": "PRS23_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY61", "type": "external" } ], "mass": 43160.0, "length": 383, "protein_name": "Serine protease 23", "gene_name": "Prss23", "organism": "Rat", "refseq_name": "serine protease 23 precursor", "refseq_ac": [ { "id": "NP_001007692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007692", "type": "external" } ], "gene_names_uniprotkb": "Prss23", "gene_names_refseq": "Prss23", "protein_names_uniprotkb": "Serine protease 23; 3.4.21.-", "protein_names_refseq": "protease, serine, 23; serine protease 23 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:308807); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY61-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6Q760-1", "uniprot_id": [ { "id": "NALCN_RAT", "url": "https://www.uniprot.org/uniprot/Q6Q760", "type": "external" } ], "mass": 200491.0, "length": 1738, "protein_name": "Sodium leak channel NALCN", "gene_name": "Nalcn", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nalcn; Nca; Rb21; Vgcnl1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium leak channel NALCN; Four domain-type voltage-gated ion channel alpha-1 subunit; Rb21-channel; Sodium leak channel non-selective protein; Voltage gated channel-like protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital limbs-face contractures-hypotonia-developmental delay syndrome (Disease Ontology:DOID:0081048)", "pathway": " (rno:266760); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10094463;17448995;22673903;33273469", "class_list": "", "function": "Voltage-sensing, pore-forming subunit of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents (By similarity). The NALCN channelosome complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (By similarity). The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (By similarity). In addition to its role in regulating neuronal excitability, is required for normal respiratory rhythm, systemic osmoregulation by controlling the serum sodium concentration and in the regulation of the intestinal pace-making activity in the interstitial cells of Cajal (By similarity). Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability (By similarity). NALCN channel is also activated by neuropeptides such as neurotensin and substance P (SP) through a SRC family kinases-dependent pathway (By similarity). In addition, NALCN activity is enhanced/modulated by several GPCRs, such as CHRM3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9Z165", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005261 monoatomic cation channel activity;GO:0005248 voltage-gated sodium channel activity;GO:0022840 leak channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001518 voltage-gated sodium channel complex;GO:0016020 membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0032230 positive regulation of synaptic transmission, GABAergic;GO:0035725 sodium ion transmembrane transport;GO:0070588 calcium ion transmembrane transport;GO:0060075 regulation of resting membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6Q760-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63065-1", "uniprot_id": [ { "id": "PDK1_RAT", "url": "https://www.uniprot.org/uniprot/Q63065", "type": "external" } ], "mass": 49081.0, "length": 434, "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial", "gene_name": "Pdk1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pdk1; Pdh", "gene_names_refseq": "", "protein_names_uniprotkb": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; 2.7.11.2; PDH kinase 1; PDK p48; Pyruvate dehydrogenase kinase isoform 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-204174); (R-RNO-5362517); (R-RNO-9837999)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "11486000;11723055;11978179;12573248;21541279;22575885;22948140;8253790;9405293", "class_list": "", "function": "Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007166 cell surface receptor signaling pathway;GO:0008283 cell population proliferation;GO:0010906 regulation of glucose metabolic process;GO:0018105 peptidyl-serine phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q63065-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY23-1", "uniprot_id": [ { "id": "P5CR2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY23", "type": "external" } ], "mass": 33673.0, "length": 320, "protein_name": "Pyrroline-5-carboxylate reductase 2", "gene_name": "Pycr2", "organism": "Rat", "refseq_name": "pyrroline-5-carboxylate reductase 2", "refseq_ac": [ { "id": "NP_001012208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012208", "type": "external" } ], "gene_names_uniprotkb": "Pycr2", "gene_names_refseq": "Pycr2", "protein_names_uniprotkb": "Pyrroline-5-carboxylate reductase 2; 1.5.1.2; P5C reductase 2; P5CR 2", "protein_names_refseq": "P5C reductase 2; P5CR 2; pyrroline-5-carboxylate reductase 2; pyrroline-5-carboxylate reductase family, member 2", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy 10 (Disease Ontology:DOID:0060788); autosomal recessive cutis laxa type IIB (Disease Ontology:DOID:0070137)", "pathway": " (rno:364064); (R-RNO-8964539)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0004735 pyrroline-5-carboxylate reductase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0055129 L-proline biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY23-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5CZZ9-1", "uniprot_id": [ { "id": "PI51B_RAT", "url": "https://www.uniprot.org/uniprot/Q5CZZ9", "type": "external" } ], "mass": 60733.0, "length": 539, "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 beta", "gene_name": "Pip5k1b", "organism": "Rat", "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase type-1 beta", "refseq_ac": [ { "id": "NP_001012761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012761", "type": "external" } ], "gene_names_uniprotkb": "Pip5k1b", "gene_names_refseq": "Pip5k1a; Pip5k1b", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; 2.7.1.68; PIP5K1-beta; PIP5KIalpha; PIP5KIbeta; Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Phosphatidylinositol 4-phosphate 5-kinase type I beta; PtdIns(4)P-5-kinase 1 beta", "protein_names_refseq": "PIP5K1-beta; PIP5KIalpha; PIP5KIbeta; phosphatidylinositol 4-phosphate 5-kinase type I alpha; phosphatidylinositol 4-phosphate 5-kinase type I beta; phosphatidylinositol 4-phosphate 5-kinase type-1 beta; phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha; ptdIns(4)P-5-kinase 1 beta; ptdIns(4)P-5-kinase beta", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:309419); (R-RNO-1660499); (R-RNO-201688); (R-RNO-6811558)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "19549683;20720456;22673903;23538529", "class_list": "", "function": "Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G protein-coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Ganglioside treatment of primary astrocytes enhances PIP5Kalpha expression. PIP5Kalpha knockdown attenuates ganglioside-induced inflammatory responses., [RefSeq, PubMed]; PIP5Kalpha acts as a negative regulator of nerve growth factor-induced neurite outgrowth by inhibiting PI3K/Akt signaling pathway in PC12 cells. Publication Status: Online-Only, [RefSeq, PubMed]; The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.68", "type": "external" }, { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity;GO:0052742 phosphatidylinositol kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0001931 uropod;GO:0005737 cytoplasm", "go_biological_process": "GO:0006661 phosphatidylinositol biosynthetic process;GO:0046488 phosphatidylinositol metabolic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5CZZ9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63632-1", "uniprot_id": [ { "id": "S12A4_RAT", "url": "https://www.uniprot.org/uniprot/Q63632", "type": "external" } ], "mass": 120628.0, "length": 1085, "protein_name": "Solute carrier family 12 member 4", "gene_name": "Slc12a4", "organism": "Rat", "refseq_name": "solute carrier family 12 member 4", "refseq_ac": [ { "id": "NP_062102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062102", "type": "external" } ], "gene_names_uniprotkb": "Slc12a4; Kcc1", "gene_names_refseq": "Kcc1; Slc12a4", "protein_names_uniprotkb": "Solute carrier family 12 member 4; Electroneutral potassium-chloride cotransporter 1; Erythroid K-Cl cotransporter 1; Furosemide-sensitive K-Cl cotransporter; rKCC1", "protein_names_refseq": "electroneutral potassium-chloride cotransporter 1; erythroid K-Cl cotransporter 1; furosemide-sensitive K-Cl cotransporter; rKCC1; solute carrier family 12 (potassium/chloride transporter), member 4; solute carrier family 12 (potassium/chloride transporters), member 4; solute carrier family 12 member 4", "tax_id": 10116, "disease": "multiple synostoses syndrome (Disease Ontology:DOID:0050794); multiple synostoses syndrome 3 (Disease Ontology:DOID:0081319); lung cancer (Disease Ontology:DOID:1324); epilepsy (Disease Ontology:DOID:1826); kidney cancer (Disease Ontology:DOID:263); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pleuropulmonary blastoma (Disease Ontology:DOID:4769)", "pathway": " (rno:29501); (R-RNO-426117)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10347194;10564083;15356206;15533301;21112289;22673903;8663127", "class_list": "", "function": "Distribution of KCC1, KCC3a, KCC3b, KCC4, and KCC2 protein and mrna in pancreatic alpha-cells and beta-cells; KCC's make a significant contribution to volume homeostasis only in alpha-cells, [RefSeq, PubMed]; KCC1 affects water transport solely by K(+) extrusion. Intracellular K(+) retention conceivably leads to cell swelling, followed by an increased rate of endocytic AQP2 retrieval from the apical membrane., [RefSeq, PubMed]; KCC1 is expressed in olfactory epithelium and participates in generation of the excitatory receptor current., [RefSeq, PubMed]; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10347194). May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P70632", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0015379 potassium:chloride symporter activity;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63632-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHQ7-1", "uniprot_id": [ { "id": "SYTL4_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHQ7", "type": "external" } ], "mass": 75900.0, "length": 672, "protein_name": "Synaptotagmin-like protein 4", "gene_name": "Sytl4", "organism": "Rat", "refseq_name": "synaptotagmin-like protein 4", "refseq_ac": [ { "id": "NP_536335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536335", "type": "external" } ], "gene_names_uniprotkb": "Sytl4", "gene_names_refseq": "Sytl4", "protein_names_uniprotkb": "Synaptotagmin-like protein 4; Exophilin-2; Granuphilin", "protein_names_refseq": "exophilin-2; granuphilin b; synaptotagmin-like 4 (granuphilin-a); synaptotagmin-like protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:140594); (R-RNO-114608)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "12058058;12176990;18573236;19082571;22673903", "class_list": "", "function": "Binds to Rab3 and Munc-19 in pancreatic beta-cells and controls exocytosis, [RefSeq, PubMed]; Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results support a role of PGC-1 in the regulation of insulin secretion via upregulation of UCP2 and granuphilin gene expression., [RefSeq, PubMed]; Sytl4 controls regulated dense-core vesicle exocytosis via binding to Rab27A, [RefSeq, PubMed]; Three Rab3/27 effectors, Granuphilin, Noc2, and Rabphilin, in PC12 cells using fluorescence recovery after photobleaching of EGFP-tagged proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8VHQ6", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030141 secretory granule;GO:0016324 apical plasma membrane;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0071985 multivesicular body sorting pathway;GO:0006886 intracellular protein transport;GO:0050714 positive regulation of protein secretion;GO:0046676 negative regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8VHQ7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKG1-1", "uniprot_id": [ { "id": "SPICE_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKG1", "type": "external" } ], "mass": 96322.0, "length": 868, "protein_name": "Spindle and centriole-associated protein 1", "gene_name": "Spice1", "organism": "Rat", "refseq_name": "spindle and centriole-associated protein 1", "refseq_ac": [ { "id": "NP_001008286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008286", "type": "external" } ], "gene_names_uniprotkb": "Spice1; Ccdc52", "gene_names_refseq": "Ccdc52; RGD1310729; Spice1", "protein_names_uniprotkb": "Spindle and centriole-associated protein 1; Coiled-coil domain-containing protein 52", "protein_names_refseq": "coiled-coil domain containing 52; coiled-coil domain-containing protein 52; spindle and centriole-associated protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:288111)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0046599 regulation of centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RKG1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XFX0-1", "uniprot_id": [ { "id": "TAGL2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XFX0", "type": "external" } ], "mass": 22393.0, "length": 199, "protein_name": "Transgelin-2", "gene_name": "Tagln2", "organism": "Rat", "refseq_name": "transgelin-2", "refseq_ac": [ { "id": "NP_001013145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013145", "type": "external" } ], "gene_names_uniprotkb": "Tagln2", "gene_names_refseq": "Tagln2", "protein_names_uniprotkb": "Transgelin-2", "protein_names_refseq": "transgelin-2", "tax_id": 10116, "disease": "", "pathway": " (rno:304983); (R-RNO-114608)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XFX0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2Y0-1", "uniprot_id": [ { "id": "WIPI4_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2Y0", "type": "external" } ], "mass": 34587.0, "length": 309, "protein_name": "WD repeat domain phosphoinositide-interacting protein 4", "gene_name": "Wdr45", "organism": "Rat", "refseq_name": "WD repeat domain phosphoinositide-interacting protein 4 isoform 2", "refseq_ac": [ { "id": "NP_001013980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013980", "type": "external" } ], "gene_names_uniprotkb": "Wdr45; Wipi4", "gene_names_refseq": "Wdr45", "protein_names_uniprotkb": "WD repeat domain phosphoinositide-interacting protein 4; WD repeat-containing protein 45; WIPI-4", "protein_names_refseq": "WD repeat domain phosphoinositide-interacting protein 4 isoform 2; WD repeat domain phosphoinositide-interacting protein 4; WD repeat-containing protein 45; WIPI-4", "tax_id": 10116, "disease": "neurodegeneration with brain iron accumulation 5 (Disease Ontology:DOID:0110739)", "pathway": " (rno:302559); (R-RNO-1632852)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21802374", "class_list": "", "function": "Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:21802374). Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005829 cytosol;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006914 autophagy;GO:0034497 protein localization to phagophore assembly site;GO:0009267 cellular response to starvation;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U2Y0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62687-1", "uniprot_id": [ { "id": "S6A18_RAT", "url": "https://www.uniprot.org/uniprot/Q62687", "type": "external" } ], "mass": 69556.0, "length": 615, "protein_name": "Sodium-dependent neutral amino acid transporter B(0)AT3", "gene_name": "Slc6a18", "organism": "Rat", "refseq_name": "sodium-dependent neutral amino acid transporter B(0)AT3", "refseq_ac": [ { "id": "NP_058859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058859", "type": "external" } ], "gene_names_uniprotkb": "Slc6a18; B0at3; Xtrp2", "gene_names_refseq": "Rosit; Slc6a18; Xtrp2", "protein_names_uniprotkb": "Sodium-dependent neutral amino acid transporter B(0)AT3; ROSIT; Renal osmotic stress-induced Na-Cl organic solute cotransporter; Sodium- and chloride-dependent transporter XTRP2; Solute carrier family 6 member 18; System B(0) neutral amino acid transporter AT3", "protein_names_refseq": "X transporter protein 2; b(0)AT3; renal osmotic stress-induced Na-Cl organic solute cotransporter; sodium- and chloride-dependent transporter XTRP2; sodium-dependent neutral amino acid transporter B(0)AT3; solute carrier family 6 (neurotransmitter transporter), member 18; solute carrier family 6 (neutral amino acid transporter), member 18; system B(0) neutral amino acid transporter AT3", "tax_id": 10116, "disease": "", "pathway": " (rno:29323)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15056985;7943364", "class_list": "", "function": "Regulation of ROSIT mRNA levels in nephrons., [RefSeq, PubMed]; Symporter that transports one amino acid molecule together with two sodium and one chloride ions in kidneys and plays a role in the neutral amino acids reabsorption. Preferentially transports neutral amino acids such as L-glycine and L-alanine but also other neutral amino acids. Required CLTRN for cell surface expression and for its amino acid transporter activity. The transport mechanism is pH-independent., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0140931 neutral L-amino acid:sodium:chloride symporter activity;GO:0046872 metal ion binding;GO:0015293 symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0015804 neutral amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0003333 amino acid transmembrane transport;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62687-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKH7-1", "uniprot_id": [ { "id": "S35F6_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKH7", "type": "external" } ], "mass": 41092.0, "length": 372, "protein_name": "Solute carrier family 35 member F6", "gene_name": "Slc35f6", "organism": "Rat", "refseq_name": "solute carrier family 35 member F6 precursor", "refseq_ac": [ { "id": "NP_001017451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017451", "type": "external" } ], "gene_names_uniprotkb": "Slc35f6", "gene_names_refseq": "ANT2BP; RGD1309228; Slc35f6", "protein_names_uniprotkb": "Solute carrier family 35 member F6; ANT2-binding protein; ANT2BP; Transport and Golgi organization 9 homolog", "protein_names_refseq": "ANT2-binding protein; solute carrier family 35 member F6 precursor; transmembrane protein C2orf18 homolog; transport and Golgi organization 9 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:298851)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity)., [UniProtKB]; May play a role as a nucleotide-sugar transporter., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RKH7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H61-1", "uniprot_id": [ { "id": "SYQ_RAT", "url": "https://www.uniprot.org/uniprot/Q66H61", "type": "external" } ], "mass": 87700.0, "length": 775, "protein_name": "Glutamine--tRNA ligase", "gene_name": "Qars1", "organism": "Rat", "refseq_name": "glutamine--tRNA ligase", "refseq_ac": [ { "id": "NP_001007625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007625", "type": "external" } ], "gene_names_uniprotkb": "Qars1; Qars", "gene_names_refseq": "GlnRS; Qars1; Qars; RGD1562301", "protein_names_uniprotkb": "Glutamine--tRNA ligase; 6.1.1.18; GlnRS; Glutaminyl-tRNA synthetase", "protein_names_refseq": "glutamine--tRNA ligase", "tax_id": 10116, "disease": "sciatic neuropathy (Disease Ontology:DOID:11446)", "pathway": " (rno:290868); (R-RNO-9856649)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25467976;29393594", "class_list": "", "function": "Glutamine--tRNA ligase. Plays a critical role in brain development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1LPA0", "ec_number_list": [ { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0004819 glutamine-tRNA ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0007420 brain development;GO:2001234 negative regulation of apoptotic signaling pathway;GO:0006425 glutaminyl-tRNA aminoacylation;GO:0032873 negative regulation of stress-activated MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66H61-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69AB1-1", "uniprot_id": [ { "id": "TXND8_RAT", "url": "https://www.uniprot.org/uniprot/Q69AB1", "type": "external" } ], "mass": 14569.0, "length": 127, "protein_name": "Thioredoxin domain-containing protein 8", "gene_name": "Txndc8", "organism": "Rat", "refseq_name": "thioredoxin domain-containing protein 8", "refseq_ac": [ { "id": "NP_001004092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004092", "type": "external" } ], "gene_names_uniprotkb": "Txndc8; Sptrx3", "gene_names_refseq": "Sptrx3; Txndc8", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 8; Spermatid-specific thioredoxin-3; Sptrx-3", "protein_names_refseq": "spermatocyte/spermatid-specific thioredoxin-3; sptrx-3; thioredoxin domain-containing protein 8", "tax_id": 10116, "disease": "male infertility (Disease Ontology:DOID:12336)", "pathway": " (rno:362525)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15181017", "class_list": "", "function": "May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SPTRX3 is a novel Golgi apparatus-associated thioredoxin, and has a role in aberrant spermatogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007283 spermatogenesis;GO:0001675 acrosome assembly;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q69AB1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63374-1", "uniprot_id": [ { "id": "NRX2A_RAT", "url": "https://www.uniprot.org/uniprot/Q63374", "type": "external" } ], "mass": 185169.0, "length": 1715, "protein_name": "Neurexin-2", "gene_name": "Nrxn2", "organism": "Rat", "refseq_name": "neurexin-2-beta precursor", "refseq_ac": [ { "id": "NP_446298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446298", "type": "external" } ], "gene_names_uniprotkb": "Nrxn2", "gene_names_refseq": "Nrxn2", "protein_names_uniprotkb": "Neurexin-2; Neurexin II-alpha; Neurexin-2-alpha", "protein_names_refseq": "neurexin II-alpha; neurexin II-beta; neurexin-2-alpha; neurexin-2-beta precursor; neurexin-2-beta", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (rno:116595); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "11470830;1621094;18334216;18755801;33164324;38843836;7695896;8163501;8576240;8786425;9647694;9856994", "class_list": "", "function": "Beta-NRX insertion sequence 4 may function in roles independent of neuroligin binding., [RefSeq, PubMed]; Data show beta-cell expression of the neurexin 2, and demonstrate that the neurexins are expressed outside the central nervous system and help confer an inhibitory synaptic-like phenotype onto the beta-cell surface., [RefSeq, PubMed]; Neurexin-2 is a potential regulator of inflammatory pain in the spinal dorsal horn of rats., [RefSeq, PubMed]; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion., [UniProtKB]; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q63375", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0005246 calcium channel regulator activity;GO:0050839 cell adhesion molecule binding;GO:0097109 neuroligin family protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0032991 protein-containing complex;GO:0036057 slit diaphragm", "go_biological_process": "GO:0099054 presynapse assembly;GO:0097116 gephyrin clustering involved in postsynaptic density assembly;GO:0097104 postsynaptic membrane assembly;GO:0007155 cell adhesion;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q63374-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VHE9-1", "uniprot_id": [ { "id": "RETST_RAT", "url": "https://www.uniprot.org/uniprot/Q8VHE9", "type": "external" } ], "mass": 67531.0, "length": 609, "protein_name": "All-trans-retinol 13,14-reductase", "gene_name": "Retsat", "organism": "Rat", "refseq_name": "all-trans-retinol 13,14-reductase precursor", "refseq_ac": [ { "id": "NP_659552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659552", "type": "external" } ], "gene_names_uniprotkb": "Retsat; Ppsig; Rmt7", "gene_names_refseq": "Retsat; Rmt7", "protein_names_uniprotkb": "All-trans-retinol 13,14-reductase; 1.3.99.23; All-trans-13,14-dihydroretinol saturase; PPAR-alpha-regulated and starvation-induced gene protein; RMT-7; RetSat", "protein_names_refseq": "PPAR-alpha-regulated and starvation-induced gene protein; RMT-7; all-trans-13,14-dihydroretinol saturase; all-trans-retinol 13,14-reductase precursor; all-trans-retinol 13,14-reductase; hypothetical protein RMT-7; retinol saturase (all trans retinol 13,14 reductase)", "tax_id": 10116, "disease": "", "pathway": " (rno:246298)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11753649", "class_list": "", "function": "Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. May play a role in adipocyte differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.99.23", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.99.23", "type": "external" } ], "go_molecular_function": "GO:0051786 all-trans-retinol 13,14-reductase activity", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0042572 retinol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8VHE9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI60-1", "uniprot_id": [ { "id": "REEP6_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI60", "type": "external" } ], "mass": 23313.0, "length": 211, "protein_name": "Receptor expression-enhancing protein 6", "gene_name": "Reep6", "organism": "Rat", "refseq_name": "receptor expression-enhancing protein 6", "refseq_ac": [ { "id": "NP_001013236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013236", "type": "external" } ], "gene_names_uniprotkb": "Reep6; Dp1l1", "gene_names_refseq": "Dp1l1; Reep6", "protein_names_uniprotkb": "Receptor expression-enhancing protein 6; Polyposis locus protein 1-like 1", "protein_names_refseq": "deleted in polyposis 1-like 1; polyposis locus protein 1-like 1; receptor expression-enhancing protein 6", "tax_id": 10116, "disease": "retinitis pigmentosa 77 (Disease Ontology:DOID:0080350); hereditary spastic paraplegia 31 (Disease Ontology:DOID:0110782)", "pathway": " (rno:362835)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15728532;36064821", "class_list": "", "function": "MiR-672-5p-Mediated Upregulation of REEP6 in Spinal Dorsal Horn Participates in Bortezomib-Induced Neuropathic Pain in Rats., [RefSeq, PubMed]; Required for correct function and survival of retinal photoreceptors (By similarity). Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity)., [UniProtKB, UniProtKB]; TB2-like 1 is a membrane protein that belongs to the YOP1/TB2/DP1/HVA22 family, and it probably plays an important role in intracellular membrane trafficking in RGCs, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0045177 apical part of cell;GO:0005789 endoplasmic reticulum membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5XI60-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62901-1", "uniprot_id": [ { "id": "RERE_RAT", "url": "https://www.uniprot.org/uniprot/Q62901", "type": "external" } ], "mass": 171815.0, "length": 1559, "protein_name": "Arginine-glutamic acid dipeptide repeats protein", "gene_name": "Rere", "organism": "Rat", "refseq_name": "arginine-glutamic acid dipeptide repeats protein", "refseq_ac": [ { "id": "NP_446337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446337", "type": "external" } ], "gene_names_uniprotkb": "Rere; Arp", "gene_names_refseq": "Arp; Rere", "protein_names_uniprotkb": "Arginine-glutamic acid dipeptide repeats protein; Atrophin-1-related protein", "protein_names_refseq": "arginine-glutamic acid dipeptide (RE) repeats; arginine-glutamic acid dipeptide repeats protein; atrophin-1-related protein", "tax_id": 10116, "disease": "dentatorubral-pallidoluysian atrophy (Disease Ontology:DOID:0060162)", "pathway": " (rno:116665)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;9173919", "class_list": "", "function": "Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival (By similarity). Interacts with FAT1 (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0016605 PML body;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0048755 branching morphogenesis of a nerve;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0048813 dendrite morphogenesis;GO:0021549 cerebellum development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62901-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63616-1", "uniprot_id": [ { "id": "VP33B_RAT", "url": "https://www.uniprot.org/uniprot/Q63616", "type": "external" } ], "mass": 70693.0, "length": 617, "protein_name": "Vacuolar protein sorting-associated protein 33B", "gene_name": "Vps33b", "organism": "Rat", "refseq_name": "vacuolar protein sorting-associated protein 33B", "refseq_ac": [ { "id": "NP_071622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071622", "type": "external" } ], "gene_names_uniprotkb": "Vps33b", "gene_names_refseq": "Vps33b", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 33B; r-vps33b", "protein_names_refseq": "r-vps33b; vacuolar protein sorting 33 homolog B; vacuolar protein sorting 33B; vacuolar protein sorting homolog r-vps33b; vacuolar protein sorting-associated protein 33B", "tax_id": 10116, "disease": "ARC syndrome (Disease Ontology:DOID:0050763); progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221); arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); arthrogryposis, renal dysfunction, and cholestasis 1 (Disease Ontology:DOID:0111353); cholestasis (Disease Ontology:DOID:13580); kidney disease (Disease Ontology:DOID:557)", "pathway": " (rno:64060)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8996080", "class_list": "", "function": "May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070889 platelet alpha granule organization;GO:0006886 intracellular protein transport;GO:0015031 protein transport;GO:0030199 collagen fibril organization;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63616-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q812E4-1", "uniprot_id": [ { "id": "SYTL5_RAT", "url": "https://www.uniprot.org/uniprot/Q812E4", "type": "external" } ], "mass": 83645.0, "length": 753, "protein_name": "Synaptotagmin-like protein 5", "gene_name": "Sytl5", "organism": "Rat", "refseq_name": "synaptotagmin-like protein 5 isoform 1", "refseq_ac": [ { "id": "NP_848016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848016", "type": "external" } ], "gene_names_uniprotkb": "Sytl5; Slp5", "gene_names_refseq": "Sytl5", "protein_names_uniprotkb": "Synaptotagmin-like protein 5", "protein_names_refseq": "synaptotagmin 15; synaptotagmin-like protein 5 isoform 1; synaptotagmin-like protein 5", "tax_id": 10116, "disease": "", "pathway": " (rno:302538)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12590134", "class_list": "", "function": "May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids (By similarity)., [UniProtKB]; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0070382 exocytic vesicle;GO:0016020 membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q812E4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6TUD4-1", "uniprot_id": [ { "id": "YIPF3_RAT", "url": "https://www.uniprot.org/uniprot/Q6TUD4", "type": "external" } ], "mass": 37973.0, "length": 347, "protein_name": "Protein YIPF3", "gene_name": "Yipf3", "organism": "Rat", "refseq_name": "protein YIPF3", "refseq_ac": [ { "id": "NP_001007802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007802", "type": "external" } ], "gene_names_uniprotkb": "Yipf3", "gene_names_refseq": "C6orf109; KLIP1; LRRGT00110; RGD1308185; Yipf3", "protein_names_uniprotkb": "Protein YIPF3; Liver regeneration-related protein LRRGT00110; YIP1 family member 3", "protein_names_refseq": "YIP1 family member 3; liver regeneration-related protein LRRGT00110; natural killer cell-specific antigen KLIP1; protein YIPF3", "tax_id": 10116, "disease": "", "pathway": " (rno:301245)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity)., [UniProtKB]; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030133 transport vesicle", "go_biological_process": "GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6TUD4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIS7-1", "uniprot_id": [ { "id": "UBAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIS7", "type": "external" } ], "mass": 55140.0, "length": 502, "protein_name": "Ubiquitin-associated protein 1", "gene_name": "Ubap1", "organism": "Rat", "refseq_name": "ubiquitin-associated protein 1", "refseq_ac": [ { "id": "NP_001012190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012190", "type": "external" } ], "gene_names_uniprotkb": "Ubap1", "gene_names_refseq": "UBAP-1; Ubap1", "protein_names_uniprotkb": "Ubiquitin-associated protein 1; UBAP-1", "protein_names_refseq": "UBAP; ubiquitin-associated protein 1", "tax_id": 10116, "disease": "hereditary spastic paraplegia 80 (Disease Ontology:DOID:0112341)", "pathway": " (rno:362502); (R-RNO-917729)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000813 ESCRT I complex", "go_biological_process": "GO:0015031 protein transport;GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIS7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7T4-1", "uniprot_id": [ { "id": "YIPF4_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7T4", "type": "external" } ], "mass": 27283.0, "length": 246, "protein_name": "Protein YIPF4", "gene_name": "Yipf4l1; Yipf4", "organism": "Rat", "refseq_name": "protein YIPF4", "refseq_ac": [ { "id": "NP_001009712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009712", "type": "external" } ], "gene_names_uniprotkb": "Yipf4l1; Yipf4; Yipf4l1", "gene_names_refseq": "RGD1310157; Yipf4", "protein_names_uniprotkb": "Protein YIPF4; YIP1 family member 4", "protein_names_refseq": "YIP1 family member 4; protein YIPF4", "tax_id": 10116, "disease": "", "pathway": " (rno:362699)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the maintenance of the Golgi structure., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005802 trans-Golgi network;GO:0000139 Golgi membrane", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048280 vesicle fusion with Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7T4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3P6-1", "uniprot_id": [ { "id": "SCMC2_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3P6", "type": "external" } ], "mass": 52695.0, "length": 469, "protein_name": "Mitochondrial adenyl nucleotide antiporter SLC25A25", "gene_name": "Slc25a25", "organism": "Rat", "refseq_name": "mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 6", "refseq_ac": [ { "id": "NP_663710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663710", "type": "external" } ], "gene_names_uniprotkb": "Slc25a25; Mcsc; Pcscl; Scamc2", "gene_names_refseq": "Mcsc; Pcscl; SCaMC-2; Slc25a25", "protein_names_uniprotkb": "Mitochondrial adenyl nucleotide antiporter SLC25A25; Mitochondrial calcium-dependent solute carrier; SCaMC-2; Short calcium-binding mitochondrial carrier protein 2; Solute carrier family 25 member 25", "protein_names_refseq": "ATP-Mg/Pi carrier; calcium-binding mitochondrial carrier protein SCaMC-2; mitochondrial ATP-Mg/Pi carrier protein; mitochondrial Ca2+-dependent solute carrier; mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 6; mitochondrial adenyl nucleotide antiporter SLC25A25; mitochondrial calcium-dependent solute carrier; peroxisomal Ca(2+)-dependent solute carrier-like protein; peroxisomal Ca-dependent solute carrier-like protein; short calcium-binding mitochondrial carrier protein 2; small calcium-binding mitochondrial carrier protein 2; solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25", "tax_id": 10116, "disease": "", "pathway": " (rno:246771)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12645546;12851217;15054102;23062354", "class_list": "", "function": "A biophysical model of the APC, [RefSeq, PubMed]; ATP magnesium phosphate carrier, by regulating the matrix adenine nucleotide content, can modulate the sensitivity of rat liver mitochondria to undergo permeability transition, [RefSeq, PubMed]; Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Has calcium-dependent ATP-magnesium/inorganic phosphate antiporter. Could have a broader specificity for adenyl nucleotides. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. Acts downstream of Ca(2+)-permeable cation channel PKD2/TRPP2 and it is likely that PKD2-mediated Ca(2+) signaling activates SLC25A25 antiporter activity. Required for left-right pattern specification., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; May play an important role in regulating the function of hepatocytes rather than in differentiation in vivo, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0005347 ATP transmembrane transporter activity;GO:0140987 ATP:phosphate antiporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0060612 adipose tissue development;GO:0032094 response to food;GO:0035264 multicellular organism growth;GO:0014823 response to activity;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8K3P6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M880-1", "uniprot_id": [ { "id": "S66A2_RAT", "url": "https://www.uniprot.org/uniprot/Q5M880", "type": "external" } ], "mass": 30571.0, "length": 271, "protein_name": "Solute carrier family 66 member 2", "gene_name": "Slc66a2", "organism": "Rat", "refseq_name": "solute carrier family 66 member 2 isoform X1", "refseq_ac": [ { "id": "XP_006255014", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255014", "type": "external" } ], "gene_names_uniprotkb": "Slc66a2; Pqlc1", "gene_names_refseq": "Pqlc1; Slc66a2", "protein_names_uniprotkb": "Solute carrier family 66 member 2; PQ-loop repeat-containing protein 1", "protein_names_refseq": "solute carrier family 66 member 2 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:361352)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane;GO:0010008 endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M880-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6G5-1", "uniprot_id": [ { "id": "YIPF1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6G5", "type": "external" } ], "mass": 34283.0, "length": 306, "protein_name": "Protein YIPF1", "gene_name": "Yipf1", "organism": "Rat", "refseq_name": "protein YIPF1", "refseq_ac": [ { "id": "NP_955415", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955415", "type": "external" } ], "gene_names_uniprotkb": "Yipf1", "gene_names_refseq": "Yipf1", "protein_names_uniprotkb": "Protein YIPF1; YIP1 family member 1", "protein_names_refseq": "YIP1 family member 1; protein YIPF1", "tax_id": 10116, "disease": "", "pathway": " (rno:298312)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031902 late endosome membrane;GO:0030133 transport vesicle;GO:0005797 Golgi medial cisterna;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P6G5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PR01-1", "uniprot_id": [ { "id": "PPDPF_RAT", "url": "https://www.uniprot.org/uniprot/Q5PR01", "type": "external" } ], "mass": 12088.0, "length": 115, "protein_name": "Pancreatic progenitor cell differentiation and proliferation factor", "gene_name": "Ppdpf", "organism": "Rat", "refseq_name": "pancreatic progenitor cell differentiation and proliferation factor", "refseq_ac": [ { "id": "NP_001009316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009316", "type": "external" } ], "gene_names_uniprotkb": "Ppdpf; Exdpf", "gene_names_refseq": "Ppdpf; RGD1310660", "protein_names_uniprotkb": "Pancreatic progenitor cell differentiation and proliferation factor; Exocrine differentiation and proliferation factor", "protein_names_refseq": "exocrine differentiation and proliferation factor; pancreatic progenitor cell differentiation and proliferation factor homolog; pancreatic progenitor cell differentiation and proliferation factor", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208)", "pathway": " (rno:296470)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable regulator of exocrine pancreas development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0001889 liver development;GO:0030154 cell differentiation;GO:0031929 TOR signaling;GO:0038202 TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PR01-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIP9-1", "uniprot_id": [ { "id": "TMM43_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIP9", "type": "external" } ], "mass": 44774.0, "length": 400, "protein_name": "Transmembrane protein 43", "gene_name": "Tmem43", "organism": "Rat", "refseq_name": "transmembrane protein 43", "refseq_ac": [ { "id": "NP_001007746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007746", "type": "external" } ], "gene_names_uniprotkb": "Tmem43", "gene_names_refseq": "Tmem43", "protein_names_uniprotkb": "Transmembrane protein 43; Protein LUMA", "protein_names_refseq": "transmembrane protein 43", "tax_id": 10116, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); autosomal dominant Emery-Dreifuss muscular dystrophy 7 (Disease Ontology:DOID:0070252); arrhythmogenic right ventricular dysplasia 5 (Disease Ontology:DOID:0110074); autosomal dominant auditory neuropathy 3 (Disease Ontology:DOID:0112373)", "pathway": " (rno:362401)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (By similarity). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005248 voltage-gated sodium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0022843 voltage-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0007613 memory;GO:0045087 innate immune response;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIP9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ES0-1", "uniprot_id": [ { "id": "TR140_RAT", "url": "https://www.uniprot.org/uniprot/Q67ES0", "type": "external" } ], "mass": 35686.0, "length": 312, "protein_name": "Taste receptor type 2 member 140", "gene_name": "Tas2r140", "organism": "Rat", "refseq_name": "taste receptor type 2 member 140", "refseq_ac": [ { "id": "NP_001078866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078866", "type": "external" } ], "gene_names_uniprotkb": "Tas2r140; Tas2r31", "gene_names_refseq": "Tas2r140", "protein_names_uniprotkb": "Taste receptor type 2 member 140; T2R140; T2R31; Taste receptor type 2 member 31", "protein_names_refseq": "T2R140; putative taste receptor T2R31; taste receptor type 2 member 140; taste receptor type 2 member 31", "tax_id": 10116, "disease": "", "pathway": " (rno:689869); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ES0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7A4-1", "uniprot_id": [ { "id": "UBA5_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7A4", "type": "external" } ], "mass": 44895.0, "length": 403, "protein_name": "Ubiquitin-like modifier-activating enzyme 5", "gene_name": "Uba5", "organism": "Rat", "refseq_name": "ubiquitin-like modifier-activating enzyme 5", "refseq_ac": [ { "id": "NP_001009669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009669", "type": "external" } ], "gene_names_uniprotkb": "Uba5", "gene_names_refseq": "Uba5; Ube1dc1", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme 5; UFM1-activating enzyme; Ubiquitin-activating enzyme 5", "protein_names_refseq": "UFM1-activating enzyme; ubiquitin-activating enzyme 5; ubiquitin-activating enzyme E1 domain-containing protein 1; ubiquitin-activating enzyme E1-domain containing 1; ubiquitin-like modifier-activating enzyme 5", "tax_id": 10116, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 44 (Disease Ontology:DOID:0080424); autosomal recessive spinocerebellar ataxia 24 (Disease Ontology:DOID:0111615)", "pathway": " (rno:300968); (R-RNO-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy) (By similarity). Ufmylation is essential for erythroid differentiation of both megakaryocytes and erythrocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071566 UFM1 activating enzyme activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0050905 neuromuscular process;GO:0030218 erythrocyte differentiation;GO:0034976 response to endoplasmic reticulum stress;GO:0071569 protein ufmylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M7A4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CIN9-1", "uniprot_id": [ { "id": "RFFL_RAT", "url": "https://www.uniprot.org/uniprot/Q8CIN9", "type": "external" } ], "mass": 40409.0, "length": 362, "protein_name": "E3 ubiquitin-protein ligase rififylin", "gene_name": "Rad51d; Rffl", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase rififylin isoform 2", "refseq_ac": [ { "id": "NP_001004068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004068", "type": "external" } ], "gene_names_uniprotkb": "Rad51d; Rffl; Rad51d; Rffl", "gene_names_refseq": "Rffl", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase rififylin; 2.3.2.27; FYVE-RING finger protein Sakura; RING finger and FYVE-like domain-containing protein 1; RING-type E3 ubiquitin transferase rififylin", "protein_names_refseq": "E3 ubiquitin-protein ligase rififylin isoform 2; E3 ubiquitin-protein ligase rififylin; FYVE-RING finger protein Sakura; RING finger and FYVE-like domain-containing protein 1; RING finger protein SAKURA; RING-type E3 ubiquitin transferase rififylin; fring; ring finger and FYVE like domain containing protein; ring finger and FYVE-like domain containing 1", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); hereditary breast ovarian cancer syndrome (Disease Ontology:DOID:5683)", "pathway": " (rno:282844); (R-RNO-6804757)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12859687;21357277;22673903;28827789", "class_list": "", "function": "E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling., [UniProtKB, PubMed]; Identified two novel Ub ligases, Momo and Sakura, carrying double zinc finger motif and RING finger domain in rat brain; Sakura expression is more widely detected in the brain white matter as well as in many peripheral organs, [RefSeq, PubMed]; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM., [UniProtKB, UniProtKB, UniProtKB]; Our study provides evidence to suggest that early perturbations in endocytic recycling caused by the overexpression of Rffl is a novel physiological mechanism potentially underlying the development of hypertension., [RefSeq, PubMed]; Targeted disruption of the rat Rffl-lnc1 locus caused aberrant, short QT-intervals and elevated blood pressure. Further, to specifically examine the significance of the 19bp polymorphism within the Rffl-lnc1 locus, a CRISPR/Cas9 based targeted knock-in rescue model was constructed by inserting the 19bp into the strain which contained the deletion polymorphism. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6AY29", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0010762 regulation of fibroblast migration;GO:0006886 intracellular protein transport;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8CIN9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q812D3-1", "uniprot_id": [ { "id": "PPIL3_RAT", "url": "https://www.uniprot.org/uniprot/Q812D3", "type": "external" } ], "mass": 18113.0, "length": 161, "protein_name": "Peptidyl-prolyl cis-trans isomerase-like 3", "gene_name": "Ppil3", "organism": "Rat", "refseq_name": "peptidyl-prolyl cis-trans isomerase-like 3", "refseq_ac": [ { "id": "NP_783638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783638", "type": "external" } ], "gene_names_uniprotkb": "Ppil3; Cyp10l", "gene_names_refseq": "Cyp10l; Ppil3", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase-like 3; 5.2.1.8; CYP10L; Cyclophilin-like protein PPIL3; PPIase; Rotamase PPIL3", "protein_names_refseq": "PPIase; cyclophilin-like protein 3; cyclophilin-like protein PPIL3; peptidyl-prolyl cis-trans isomerase-like 3; peptidylprolyl cis-trans isomerase-like protein 3; peptidylprolyl isomerase (cyclophilin)-like 3; rotamase PPIL3", "tax_id": 10116, "disease": "", "pathway": " (rno:301432); (R-RNO-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q812D3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PEC3-1", "uniprot_id": [ { "id": "YIF1B_RAT", "url": "https://www.uniprot.org/uniprot/Q6PEC3", "type": "external" } ], "mass": 28418.0, "length": 259, "protein_name": "Protein YIF1B", "gene_name": "Yif1b", "organism": "Rat", "refseq_name": "protein YIF1B isoform b", "refseq_ac": [ { "id": "NP_001014810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014810", "type": "external" } ], "gene_names_uniprotkb": "Yif1b; LOC103689986", "gene_names_refseq": "Yif1b; Yip1b", "protein_names_uniprotkb": "Protein YIF1B; YIP1-interacting factor homolog B", "protein_names_refseq": "YIP1-interacting factor homolog B; protein YIF1B isoform b; protein YIF1B", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:292768)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18685031;23055492;26077767", "class_list": "", "function": "A new protein trafficking pathway model is proposed in which Yif1B is the scaffold protein recruiting the 5-HT1A receptor complex., [RefSeq, PubMed]; Functions in endoplasmic reticulum to Golgi vesicle-mediated transport and regulates the proper organization of the endoplasmic reticulum and the Golgi (By similarity). Plays a key role in targeting to neuronal dendrites receptors such as HTR1A (PubMed:18685031). Plays also a role in primary cilium and sperm flagellum assembly probably through protein transport to these compartments (By similarity)., [UniProtKB, UniProtKB, PubMed]; Has a role in transport between endoplasmic reticulum and Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006612 protein targeting to membrane;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0060271 cilium assembly;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6PEC3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0L3-1", "uniprot_id": [ { "id": "SYYM_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0L3", "type": "external" } ], "mass": 52628.0, "length": 471, "protein_name": "Tyrosine--tRNA ligase, mitochondrial", "gene_name": "Yars2", "organism": "Rat", "refseq_name": "tyrosine--tRNA ligase, mitochondrial", "refseq_ac": [ { "id": "NP_001009627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009627", "type": "external" } ], "gene_names_uniprotkb": "Yars2", "gene_names_refseq": "CGI-04; RGD1311696; Yars2", "protein_names_uniprotkb": "Tyrosine--tRNA ligase, mitochondrial; 6.1.1.1; TyrRS; Tyrosyl-tRNA synthetase", "protein_names_refseq": "tyrRS; tyrosine--tRNA ligase, mitochondrial; tyrosyl-tRNA synthetase 2 (mitochondrial); tyrosyl-tRNA synthetase, mitochondrial", "tax_id": 10116, "disease": "myopathy, lactic acidosis, and sideroblastic anemia 2 (Disease Ontology:DOID:0111186)", "pathway": " (rno:287924)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0000049 tRNA binding;GO:0072545 L-tyrosine binding;GO:0004831 tyrosine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0070184 mitochondrial tyrosyl-tRNA aminoacylation;GO:0043039 tRNA aminoacylation;GO:0006437 tyrosyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0L3-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q75WE7-1", "uniprot_id": [ { "id": "VWA5A_RAT", "url": "https://www.uniprot.org/uniprot/Q75WE7", "type": "external" } ], "mass": 91483.0, "length": 822, "protein_name": "von Willebrand factor A domain-containing protein 5A", "gene_name": "Vwa5a", "organism": "Rat", "refseq_name": "von Willebrand factor A domain-containing protein 5A isoform X2", "refseq_ac": [ { "id": "XP_063121387", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063121387", "type": "external" } ], "gene_names_uniprotkb": "Vwa5a; Loh11cr2a; Masa1", "gene_names_refseq": "Loh11cr2a; Vwa5a; masa-1", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 5A; Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog; Masa-1; Mast cell surface antigen 1", "protein_names_refseq": "von Willebrand factor A domain-containing protein 5A isoform X2", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in may contribute directly to or modify tumorigenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q75WE7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVN8-1", "uniprot_id": [ { "id": "WSDU1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVN8", "type": "external" } ], "mass": 52244.0, "length": 476, "protein_name": "WD repeat, SAM and U-box domain-containing protein 1", "gene_name": "Wdsub1", "organism": "Rat", "refseq_name": "WD repeat, SAM and U-box domain-containing protein 1", "refseq_ac": [ { "id": "NP_001014201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014201", "type": "external" } ], "gene_names_uniprotkb": "Wdsub1", "gene_names_refseq": "Wdsub1", "protein_names_uniprotkb": "WD repeat, SAM and U-box domain-containing protein 1", "protein_names_refseq": "WD repeat, SAM and U-box domain containing 1; WD repeat, SAM and U-box domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362137)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVN8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK38-1", "uniprot_id": [ { "id": "TM156_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK38", "type": "external" } ], "mass": 32552.0, "length": 286, "protein_name": "Transmembrane protein 156", "gene_name": "Tmem156", "organism": "Rat", "refseq_name": "transmembrane protein 156 isoform 3", "refseq_ac": [ { "id": "NP_001020309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020309", "type": "external" } ], "gene_names_uniprotkb": "Tmem156", "gene_names_refseq": "Tmem156", "protein_names_uniprotkb": "Transmembrane protein 156", "protein_names_refseq": "transmembrane protein 156 isoform 3", "tax_id": 10116, "disease": "", "pathway": " (rno:498365)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK38-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVI6-1", "uniprot_id": [ { "id": "VATC1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVI6", "type": "external" } ], "mass": 43901.0, "length": 382, "protein_name": "V-type proton ATPase subunit C 1", "gene_name": "Atp6v1c1", "organism": "Rat", "refseq_name": "V-type proton ATPase subunit C 1", "refseq_ac": [ { "id": "NP_001011992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011992", "type": "external" } ], "gene_names_uniprotkb": "Atp6v1c1", "gene_names_refseq": "Atp6v1c1", "protein_names_uniprotkb": "V-type proton ATPase subunit C 1; V-ATPase subunit C 1; Vacuolar proton pump subunit C 1", "protein_names_refseq": "ATPase, H+ transporting, V1 subunit C; ATPase, H+ transporting, lysosomal V1 subunit C1; V-ATPase subunit C 1; V-type proton ATPase subunit C 1; vacuolar proton pump subunit C 1", "tax_id": 10116, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); cancer (Disease Ontology:DOID:162); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (rno:299971); (R-RNO-1222556); (R-RNO-77387); (R-RNO-917977); (R-RNO-9639288); (R-RNO-983712)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "32165585", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033180 proton-transporting V-type ATPase, V1 domain;GO:0033176 proton-transporting V-type ATPase complex;GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0097401 synaptic vesicle lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVI6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZF2-1", "uniprot_id": [ { "id": "WBP4_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZF2", "type": "external" } ], "mass": 42157.0, "length": 374, "protein_name": "WW domain-binding protein 4", "gene_name": "Wbp4", "organism": "Rat", "refseq_name": "WW domain-binding protein 4", "refseq_ac": [ { "id": "NP_446218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446218", "type": "external" } ], "gene_names_uniprotkb": "Wbp4", "gene_names_refseq": "Fbp21; Wbp4", "protein_names_uniprotkb": "WW domain-binding protein 4; Formin-binding protein 21; WBP-4; WW domain-containing-binding protein 4", "protein_names_refseq": "WBP-4; WW domain binding protein 4 (formin binding protein 21); WW domain-binding protein 4; WW domain-containing-binding protein 4; formin-binding protein 21", "tax_id": 10116, "disease": "", "pathway": " (rno:114765)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0070064 proline-rich region binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5HZF2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TSW6-1", "uniprot_id": [ { "id": "STIMA_RAT", "url": "https://www.uniprot.org/uniprot/Q7TSW6", "type": "external" } ], "mass": 32470.0, "length": 288, "protein_name": "Store-operated calcium entry regulator STIMATE", "gene_name": "Stimate", "organism": "Rat", "refseq_name": "store-operated calcium entry regulator STIMATE", "refseq_ac": [ { "id": "NP_942069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942069", "type": "external" } ], "gene_names_uniprotkb": "Stimate; Tmem110", "gene_names_refseq": "Stimate; Tmem110", "protein_names_uniprotkb": "Store-operated calcium entry regulator STIMATE; STIM-activating enhancer encoded by TMEM110; Transmembrane protein 110", "protein_names_refseq": "STIM-activating enhancer encoded by TMEM110; store-operated calcium entry regulator STIMATE; transmembrane protein 110", "tax_id": 10116, "disease": "", "pathway": " (rno:361110)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032541 cortical endoplasmic reticulum;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0032237 activation of store-operated calcium channel activity;GO:0002115 store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TSW6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63429-1", "uniprot_id": [ { "id": "UBC_RAT", "url": "https://www.uniprot.org/uniprot/Q63429", "type": "external" } ], "mass": 91087.0, "length": 810, "protein_name": "Polyubiquitin-C", "gene_name": "Ubc", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ubc", "gene_names_refseq": "", "protein_names_uniprotkb": "Polyubiquitin-C", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:50522); (R-RNO-110312); (R-RNO-110314); (R-RNO-110320); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1253288); (R-RNO-1295596); (R-RNO-1358803); (R-RNO-156827); (R-RNO-168638); (R-RNO-174048); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-179409); (R-RNO-1799339); (R-RNO-182971); (R-RNO-187577); (R-RNO-195253); (R-RNO-201681); (R-RNO-202424); (R-RNO-205043); (R-RNO-209543); (R-RNO-209560); (R-RNO-2122948); (R-RNO-2173788); (R-RNO-2173791); (R-RNO-2173795); (R-RNO-2173796); (R-RNO-2467813); (R-RNO-2559580); (R-RNO-2559582); (R-RNO-2559585); (R-RNO-2565942); (R-RNO-2672351); (R-RNO-2871837); (R-RNO-3134975); (R-RNO-349425); (R-RNO-3769402); (R-RNO-382556); (R-RNO-445989); (R-RNO-450302); (R-RNO-450321); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-4641263); (R-RNO-5205685); (R-RNO-532668); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5654726); (R-RNO-5654727); (R-RNO-5654732); (R-RNO-5654733); (R-RNO-5655862); (R-RNO-5656121); (R-RNO-5656169); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5675221); (R-RNO-5675482); (R-RNO-5676590); (R-RNO-5684264); (R-RNO-5685942); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689877); (R-RNO-5689880); (R-RNO-5689896); (R-RNO-5689901); (R-RNO-5693537); (R-RNO-5693565); (R-RNO-5696394); (R-RNO-5696395); (R-RNO-5696397); (R-RNO-5696400); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6783310); (R-RNO-6791226); (R-RNO-6804756); (R-RNO-6804757); (R-RNO-6804760); (R-RNO-6807004); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69231); (R-RNO-69481); (R-RNO-69541); (R-RNO-69601); (R-RNO-72689); (R-RNO-72706); (R-RNO-75815); (R-RNO-8849469); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8856825); (R-RNO-8856828); (R-RNO-8863795); (R-RNO-8866427); (R-RNO-8866652); (R-RNO-8866654); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948747); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-901032); (R-RNO-9013507); (R-RNO-9020702); (R-RNO-9033241); (R-RNO-909733); (R-RNO-912631); (R-RNO-917729); (R-RNO-917937); (R-RNO-936440); (R-RNO-936964); (R-RNO-937039); (R-RNO-937041); (R-RNO-937042); (R-RNO-937072); (R-RNO-9645460); (R-RNO-9646399); (R-RNO-9648002); (R-RNO-9664873); (R-RNO-9705462); (R-RNO-975144); (R-RNO-975163); (R-RNO-9755511); (R-RNO-9758274); (R-RNO-975956); (R-RNO-975957); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-9770562); (R-RNO-9824878); (R-RNO-983168); (R-RNO-9861718); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9931295); (R-RNO-9932298); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716); (R-RNO-9958810); (R-RNO-9958825)", "pathway_count": 161, "publication_count": 2, "publication_id_list": "8018730;8031840", "class_list": "", "function": "Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). During ubiquitination, the acceptor ubiquitin is positioned in the active site via direct interaction with the E2 ubiquitin-conjugating enzymes such as UBE2R2 (By similarity). As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBA1", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005741 mitochondrial outer membrane;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0019941 modification-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63429-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HF2-1", "uniprot_id": [ { "id": "TM9S1_RAT", "url": "https://www.uniprot.org/uniprot/Q66HF2", "type": "external" } ], "mass": 66918.0, "length": 589, "protein_name": "Transmembrane 9 superfamily member 1", "gene_name": "Tm9sf1", "organism": "Rat", "refseq_name": "transmembrane 9 superfamily member 1 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001012155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012155", "type": "external" } ], "gene_names_uniprotkb": "Tm9sf1", "gene_names_refseq": "Tm9sf1", "protein_names_uniprotkb": "Transmembrane 9 superfamily member 1", "protein_names_refseq": "transmembrane 9 superfamily member 1 isoform 2 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:361043)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role in autophagy., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006914 autophagy;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HF2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FW7-1", "uniprot_id": [ { "id": "SYTM_RAT", "url": "https://www.uniprot.org/uniprot/Q68FW7", "type": "external" } ], "mass": 81672.0, "length": 723, "protein_name": "Threonine--tRNA ligase, mitochondrial", "gene_name": "Tars2", "organism": "Rat", "refseq_name": "threonine--tRNA ligase, mitochondrial", "refseq_ac": [ { "id": "NP_001014062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014062", "type": "external" } ], "gene_names_uniprotkb": "Tars2; Tarsl1", "gene_names_refseq": "RGD1308283; Tars2; Tarsl1", "protein_names_uniprotkb": "Threonine--tRNA ligase, mitochondrial; 6.1.1.3; ThrRS; Threonyl-tRNA synthetase-like 1; Threonyl-tRNA synthetase", "protein_names_refseq": "thrRS; threonine--tRNA ligase, mitochondrial; threonyl-tRNA synthetase 2, mitochondrial (putative); threonyl-tRNA synthetase, mitochondrial; threonyl-tRNA synthetase-like 1", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 21 (Disease Ontology:DOID:0111465); nonphotosensitive trichothiodystrophy (Disease Ontology:DOID:0111867); amino acid metabolic disorder (Disease Ontology:DOID:9252)", "pathway": " (rno:310672)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004829 threonine-tRNA ligase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005737 cytoplasm", "go_biological_process": "GO:0006435 threonyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FW7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI41-1", "uniprot_id": [ { "id": "TRAM1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI41", "type": "external" } ], "mass": 43030.0, "length": 374, "protein_name": "Translocating chain-associated membrane protein 1", "gene_name": "Tram1", "organism": "Rat", "refseq_name": "translocating chain-associated membrane protein 1", "refseq_ac": [ { "id": "NP_001007702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007702", "type": "external" } ], "gene_names_uniprotkb": "Tram1; Tram", "gene_names_refseq": "Tram1", "protein_names_uniprotkb": "Translocating chain-associated membrane protein 1; Protein TRAM1", "protein_names_refseq": "translocating chain-associated membrane protein 1; translocating chain-associating membrane protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:312903)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;27105999;30338452", "class_list": "", "function": "Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel. Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER. May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport. Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane. Associates with the second TM domain of G protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane. Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome., [UniProtKB, UniProtKB]; TRAM1 can protect pancreatic inflammation by regulation of necrosis-apoptosis switch in AR42J rat pancreatic acinar cells., [RefSeq, PubMed]; TRAM1 expression increased in the dorsal root ganglion neurons and dorsal horn neurons after chronic constriction injury., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045048 protein insertion into ER membrane;GO:0006613 cotranslational protein targeting to membrane;GO:0006986 response to unfolded protein;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5XI41-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQN5-1", "uniprot_id": [ { "id": "TRI55_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQN5", "type": "external" } ], "mass": 59980.0, "length": 545, "protein_name": "Tripartite motif-containing protein 55", "gene_name": "Trim55", "organism": "Rat", "refseq_name": "tripartite motif-containing protein 55", "refseq_ac": [ { "id": "NP_001012218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012218", "type": "external" } ], "gene_names_uniprotkb": "Trim55; Murf2; Rnf29", "gene_names_refseq": "Rnf29; Trim55", "protein_names_uniprotkb": "Tripartite motif-containing protein 55; 2.3.2.27; MuRF-2; MuRF2; Muscle-specific RING finger protein 2; RING finger protein 29", "protein_names_refseq": "MURF-2; muRF2; muscle-specific RING finger protein 2; ring finger protein 29; tripartite motif-containing protein 55", "tax_id": 10116, "disease": "", "pathway": " (rno:365751)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12414993;15199100;15802564;21185285;22673903;25868327;29393594;32463795", "class_list": "", "function": "E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression. Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA. Also modifies PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity., [UniProtKB, UniProtKB, UniProtKB]; MiR-378a-3p inhibits ischemia/reperfusion-induced apoptosis in H9C2 cardiomyocytes by targeting TRIM55 via the DUSP1-JNK1/2 signaling pathway., [RefSeq, PubMed]; MuRF1 and MuRF2 translocate to the nuclei in the soleus muscle during gravitational unloading., [RefSeq, PubMed]; Neonatal rat cardiomyocytes expressing MURF2+3 specific siRNA have reduced expression of both MURF2 and -3, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0070936 protein K48-linked ubiquitination;GO:0050904 diapedesis;GO:1905517 macrophage migration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5PQN5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63798-1", "uniprot_id": [ { "id": "PSME2_RAT", "url": "https://www.uniprot.org/uniprot/Q63798", "type": "external" } ], "mass": 26857.0, "length": 238, "protein_name": "Proteasome activator complex subunit 2", "gene_name": "Psme2", "organism": "Rat", "refseq_name": "proteasome activator complex subunit 2", "refseq_ac": [ { "id": "NP_058953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058953", "type": "external" } ], "gene_names_uniprotkb": "Psme2; LOC100362709", "gene_names_refseq": "Psme2", "protein_names_uniprotkb": "Proteasome activator complex subunit 2; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; PA28beta; PA28b; Proteasome activator 28 subunit beta; REG-beta", "protein_names_refseq": "11S regulator complex subunit beta; PA28beta; PA28b; REG-beta; activator of multicatalytic protease subunit 2; protease (prosome, macropain) 28 subunit, beta; proteasome (prosome, macropain) 28 subunit, beta; proteasome (prosome, macropain) activator subunit 2; proteasome activator 28 subunit beta; proteasome activator complex subunit 2", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); ductal carcinoma in situ (Disease Ontology:DOID:0060074); intestinal cancer (Disease Ontology:DOID:10155); prostate cancer (Disease Ontology:DOID:10283); amblyopia (Disease Ontology:DOID:10376); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); HELLP syndrome (Disease Ontology:DOID:13133); lung cancer (Disease Ontology:DOID:1324); interstitial cystitis (Disease Ontology:DOID:13949); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); calcinosis (Disease Ontology:DOID:182); nephroblastoma (Disease Ontology:DOID:2154); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); laryngeal squamous cell carcinoma (Disease Ontology:DOID:2876); carcinoma (Disease Ontology:DOID:305); high grade glioma (Disease Ontology:DOID:3070); mammary Paget's disease (Disease Ontology:DOID:3443); invasive lobular carcinoma (Disease Ontology:DOID:3457); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); stomach carcinoma (Disease Ontology:DOID:5517); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); median neuropathy (Disease Ontology:DOID:571); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:29614); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-9907900); (R-RNO-9912633)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "36715894;7789512", "class_list": "", "function": "Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibition of the Proteasome Regulator PA28 Aggravates Oxidized Protein Overload in the Diabetic Rat Brain., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 34, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QR96", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000502 proteasome complex;GO:0008537 proteasome activator complex", "go_biological_process": "GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0061136 regulation of proteasomal protein catabolic process;GO:0019884 antigen processing and presentation of exogenous antigen", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63798-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2T1-1", "uniprot_id": [ { "id": "TLCD1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2T1", "type": "external" } ], "mass": 28729.0, "length": 247, "protein_name": "TLC domain-containing protein 1", "gene_name": "Tlcd1", "organism": "Rat", "refseq_name": "TLC domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001013880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013880", "type": "external" } ], "gene_names_uniprotkb": "Tlcd1", "gene_names_refseq": "Tlcd1", "protein_names_uniprotkb": "TLC domain-containing protein 1; Calfacilitin", "protein_names_refseq": "TLC domain-containing protein 1 precursor; TLC domain-containing protein 1; calfacilitin", "tax_id": 10116, "disease": "", "pathway": " (rno:287472)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates the composition and fluidity of the plasma membrane (By similarity). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (By similarity). Does not appear to have any effect on LCPUFA synthesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0055091 phospholipid homeostasis;GO:0071709 membrane assembly;GO:0097035 regulation of membrane lipid distribution", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2T1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIT3-1", "uniprot_id": [ { "id": "YIPF2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIT3", "type": "external" } ], "mass": 34798.0, "length": 311, "protein_name": "Protein YIPF2", "gene_name": "Yipf2", "organism": "Rat", "refseq_name": "protein YIPF2", "refseq_ac": [ { "id": "NP_001014230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014230", "type": "external" } ], "gene_names_uniprotkb": "Yipf2", "gene_names_refseq": "RGD1307512; Yipf2", "protein_names_uniprotkb": "Protein YIPF2; YIP1 family member 2", "protein_names_refseq": "YIP1 family member 2; protein YIPF2", "tax_id": 10116, "disease": "", "pathway": " (rno:363027)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031902 late endosome membrane;GO:0030133 transport vesicle;GO:0005797 Golgi medial cisterna;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIT3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIB9-1", "uniprot_id": [ { "id": "TIFA_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIB9", "type": "external" } ], "mass": 21548.0, "length": 185, "protein_name": "TRAF-interacting protein with FHA domain-containing protein A", "gene_name": "Tifa", "organism": "Rat", "refseq_name": "TRAF-interacting protein with FHA domain-containing protein A", "refseq_ac": [ { "id": "NP_001014066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014066", "type": "external" } ], "gene_names_uniprotkb": "Tifa", "gene_names_refseq": "Ab2-389; T2bp; Tifa", "protein_names_uniprotkb": "TRAF-interacting protein with FHA domain-containing protein A", "protein_names_refseq": "TRAF-interacting protein with FHA domain-containing protein A; TRAF2-binding protein; Traf2 binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:310877); (R-RNO-445989); (R-RNO-9645460)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0033209 tumor necrosis factor-mediated signaling pathway;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIB9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYG3-1", "uniprot_id": [ { "id": "PRUN1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYG3", "type": "external" } ], "mass": 49998.0, "length": 454, "protein_name": "Exopolyphosphatase PRUNE1", "gene_name": "Prune1", "organism": "Rat", "refseq_name": "exopolyphosphatase PRUNE1", "refseq_ac": [ { "id": "NP_001007698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007698", "type": "external" } ], "gene_names_uniprotkb": "Prune1; Prune", "gene_names_refseq": "Prune1; Prune", "protein_names_uniprotkb": "Exopolyphosphatase PRUNE1; 3.6.1.14; 3.6.1.25", "protein_names_refseq": "exopolyphosphatase PRUNE1; protein prune homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:310664)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Exopolyphosphatase that catalyzes the hydrolysis of inorganic polyphosphates, with preference for short-chain substrates, as well as nucleoside 5'-tetraphosphates, releasing terminal phosphate residues. Also exhibits phosphodiesterase activity toward cyclic nucleotides, hydrolyzing cAMP and cGMP to their corresponding 5'-monophosphates. Requires divalent metal ions for activity. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization., [UniProtKB, UniProtKB]; Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0004427 inorganic diphosphate phosphatase activity;GO:0016791 phosphatase activity;GO:0004309 exopolyphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion", "go_biological_process": "GO:0031113 regulation of microtubule polymerization;GO:0050767 regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI02-1", "uniprot_id": [ { "id": "PP4R1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VI02", "type": "external" } ], "mass": 105615.0, "length": 951, "protein_name": "Serine/threonine-protein phosphatase 4 regulatory subunit 1", "gene_name": "Ppp4r1", "organism": "Rat", "refseq_name": "serine/threonine-protein phosphatase 4 regulatory subunit 1", "refseq_ac": [ { "id": "NP_543183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543183", "type": "external" } ], "gene_names_uniprotkb": "Ppp4r1", "gene_names_refseq": "Pp4r1; Ppp4r1", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 4 regulatory subunit 1", "protein_names_refseq": "serine/threonine-protein phosphatase 4 regulatory subunit 1", "tax_id": 10116, "disease": "", "pathway": " (rno:140943)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11729228;22673903", "class_list": "", "function": "Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. Plays a role in the inhibition of TNF-induced NF-kappa-B activation by regulating the dephosphorylation of TRAF2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030289 protein phosphatase 4 complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VI02-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY28-1", "uniprot_id": [ { "id": "PRS54_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY28", "type": "external" } ], "mass": 42921.0, "length": 382, "protein_name": "Inactive serine protease 54", "gene_name": "Prss54", "organism": "Rat", "refseq_name": "inactive serine protease 54 precursor", "refseq_ac": [ { "id": "NP_001013910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013910", "type": "external" } ], "gene_names_uniprotkb": "Prss54; Klkbl4", "gene_names_refseq": "Klkbl4; Prss54; RGD1307877", "protein_names_uniprotkb": "Inactive serine protease 54; Plasma kallikrein-like protein 4", "protein_names_refseq": "inactive serine protease 54 precursor; inactive serine protease 54; plasma kallikrein-like protein 4; protease, serine, 54", "tax_id": 10116, "disease": "", "pathway": " (rno:291846)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY28-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJT4-1", "uniprot_id": [ { "id": "TXD15_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJT4", "type": "external" } ], "mass": 37928.0, "length": 343, "protein_name": "Thioredoxin domain-containing protein 15", "gene_name": "Pcbd2; Txndc15", "organism": "Rat", "refseq_name": "thioredoxin domain-containing protein 15 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001020169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020169", "type": "external" } ], "gene_names_uniprotkb": "Pcbd2; Txndc15; Txndc15", "gene_names_refseq": "RGD1304696; Txndc15", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 15", "protein_names_refseq": "thioredoxin domain-containing protein 15 isoform 2 precursor; thioredoxin domain-containing protein 15", "tax_id": 10116, "disease": "Meckel syndrome (Disease Ontology:DOID:0050778)", "pathway": " (rno:307180)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a positive regulator of ciliary hedgehog signaling. Required for cilia biogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.96", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.96", "type": "external" } ], "go_molecular_function": "GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity;GO:0042802 identical protein binding;GO:0004505 phenylalanine 4-monooxygenase activity", "go_cellular_component": "GO:0005929 cilium;GO:0060170 ciliary membrane;GO:0005634 nucleus", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0060271 cilium assembly;GO:0006729 tetrahydrobiopterin biosynthetic process;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJT4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R413-1", "uniprot_id": [ { "id": "PROK2_RAT", "url": "https://www.uniprot.org/uniprot/Q8R413", "type": "external" } ], "mass": 11594.0, "length": 107, "protein_name": "Prokineticin-2", "gene_name": "Prok2", "organism": "Rat", "refseq_name": "prokineticin-2 isoform 2 precursor", "refseq_ac": [ { "id": "NP_620207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620207", "type": "external" } ], "gene_names_uniprotkb": "Prok2; Bv8", "gene_names_refseq": "Bv8; PK2; Prok2", "protein_names_uniprotkb": "Prokineticin-2; PK2", "protein_names_refseq": "homolog of mouse Bv8 (Bombina variegata 8 kDa); prokineticin 2 beta; prokineticin 2; prokineticin-2 isoform 2 precursor", "tax_id": 10116, "disease": "hypogonadotropic hypogonadism 4 with or without anosmia (Disease Ontology:DOID:0090077)", "pathway": " (rno:192206); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12024206;12054613;31766244;31899964;32572760;36804440;37934398", "class_list": "", "function": "May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity)., [UniProtKB]; Prokineticin 2 relieves hypoxia/reoxygenation-induced injury through activation of Akt/mTOR pathway in H9c2 cardiomyocytes., [RefSeq, PubMed]; Prokineticin-2 Participates in Chronic Constriction Injury-Triggered Neuropathic Pain and Anxiety via Regulated by NF-kappaB in Nucleus Accumbens Shell in Rats., [RefSeq, PubMed]; Roles of Prokineticin 2 in Subarachnoid Hemorrhage-Induced Early Brain Injury via Regulation of Phenotype Polarization in Astrocytes. Erratum:[Mol Neurobiol. 2024 Oct;61(10):8486. doi: 10.1007/s12035-024-04149-w. PMID: 38573416], [RefSeq, PubMed]; Roles of prokineticin 2 in electroconvulsive shock-induced memory impairment via regulation of phenotype polarization in astrocytes., [RefSeq, PubMed]; We demonstrated a significant upregulation of PROK2 levels in brain tissues of Abeta1-42 i.c.v. injected rats, transgenic AD mice (Tg2576), and in the hippocampus of AD patients. Additionally, through a pilot study, an approximate twofold increase of PROK2 levels has been proved in the serum of AD patients, compared to the control subjects, identifying a potential blood-based biomarker of the disease. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0001525 angiogenesis;GO:0006935 chemotaxis;GO:0007218 neuropeptide signaling pathway;GO:0007283 spermatogenesis;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R413-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q791F6-1", "uniprot_id": [ { "id": "TPRA1_RAT", "url": "https://www.uniprot.org/uniprot/Q791F6", "type": "external" } ], "mass": 40578.0, "length": 369, "protein_name": "Transmembrane protein adipocyte-associated 1", "gene_name": "Tpra1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tpra1; Gpr175; Tpra40", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein adipocyte-associated 1; Integral membrane protein GPR175; TPRA40; Transmembrane domain protein of 40 kDa regulated in adipocytes", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:85494)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11267675", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0040016 embryonic cleavage;GO:1901991 negative regulation of mitotic cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q791F6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI83-1", "uniprot_id": [ { "id": "VP35L_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI83", "type": "external" } ], "mass": 106151.0, "length": 936, "protein_name": "VPS35 endosomal protein-sorting factor-like", "gene_name": "Vps35l", "organism": "Rat", "refseq_name": "VPS35 endosomal protein-sorting factor-like isoform 2", "refseq_ac": [ { "id": "NP_001017463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017463", "type": "external" } ], "gene_names_uniprotkb": "Vps35l; LOC361635", "gene_names_refseq": "Vps35l", "protein_names_uniprotkb": "VPS35 endosomal protein-sorting factor-like", "protein_names_refseq": "UPF0505 protein C16orf62 homolog; VPS35 endosomal protein-sorting factor-like isoform 2", "tax_id": 10116, "disease": "Ritscher-Schinzel syndrome (Disease Ontology:DOID:0060565)", "pathway": " (rno:361635); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Does not seem to be required for CCC complex stability., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0015031 protein transport;GO:0032456 endocytic recycling;GO:0006893 Golgi to plasma membrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI83-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4R9-1", "uniprot_id": [ { "id": "PP14C_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4R9", "type": "external" } ], "mass": 17980.0, "length": 164, "protein_name": "Protein phosphatase 1 regulatory subunit 14C", "gene_name": "Ppp1r14c", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 14C", "refseq_ac": [ { "id": "NP_596916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596916", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r14c; Kepi", "gene_names_refseq": "Kepi; Ppp1r14c", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 14C; Kinase-enhanced PP1 inhibitor; PKC-potentiated PP1 inhibitory protein", "protein_names_refseq": "PKC-potentiated PP1 inhibitory protein; kinase-enhanced PP1 inhibitor; protein phosphatase 1 regulatory subunit 14C", "tax_id": 10116, "disease": "Coronavirus infectious disease (Disease Ontology:DOID:0080599)", "pathway": " (rno:171010)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11812771;22673903", "class_list": "", "function": "Inhibitor of PPP1CA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Inhibitor of the PP1 regulatory subunit PPP1CA., [UniProtKB]; Regulation by morphine, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R4R9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPN5-1", "uniprot_id": [ { "id": "TPPP3_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPN5", "type": "external" } ], "mass": 18980.0, "length": 176, "protein_name": "Tubulin polymerization-promoting protein family member 3", "gene_name": "Tppp3", "organism": "Rat", "refseq_name": "tubulin polymerization-promoting protein family member 3", "refseq_ac": [ { "id": "NP_001009639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009639", "type": "external" } ], "gene_names_uniprotkb": "Tppp3", "gene_names_refseq": "CGI-38; RGD1305061; Tppp3", "protein_names_uniprotkb": "Tubulin polymerization-promoting protein family member 3", "protein_names_refseq": "tubulin polymerization-promoting protein family member 3", "tax_id": 10116, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (rno:291966)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulator of microtubule dynamic that has microtubule bundling activity (By similarity). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm;GO:0097427 microtubule bundle", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0007566 embryo implantation;GO:0046697 decidualization;GO:0001578 microtubule bundle formation;GO:0032273 positive regulation of protein polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PPN5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJS8-1", "uniprot_id": [ { "id": "TPST2_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJS8", "type": "external" } ], "mass": 42068.0, "length": 376, "protein_name": "Protein-tyrosine sulfotransferase 2", "gene_name": "Tpst2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tpst2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein-tyrosine sulfotransferase 2; 2.8.2.20; TPST-2; Tyrosylprotein sulfotransferase 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:288719); (R-RNO-156584); (R-RNO-163841)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.20", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008476 protein-tyrosine sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0060468 prevention of polyspermy;GO:0006478 peptidyl-tyrosine sulfation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RJS8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QZQ4-1", "uniprot_id": [ { "id": "VMAC_RAT", "url": "https://www.uniprot.org/uniprot/Q6QZQ4", "type": "external" } ], "mass": 18844.0, "length": 171, "protein_name": "Vimentin-type intermediate filament-associated coiled-coil protein", "gene_name": "Vmac", "organism": "Rat", "refseq_name": "vimentin-type intermediate filament-associated coiled-coil protein", "refseq_ac": [ { "id": "NP_001001720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001720", "type": "external" } ], "gene_names_uniprotkb": "Vmac", "gene_names_refseq": "Vmac", "protein_names_uniprotkb": "Vimentin-type intermediate filament-associated coiled-coil protein", "protein_names_refseq": "vimentin-type intermediate filament-associated coiled-coil protein", "tax_id": 10116, "disease": "", "pathway": " (rno:363327)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14985129", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045098 type III intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6QZQ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XFW6-1", "uniprot_id": [ { "id": "WDR6_RAT", "url": "https://www.uniprot.org/uniprot/Q5XFW6", "type": "external" } ], "mass": 121937.0, "length": 1125, "protein_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "gene_name": "Wdr6", "organism": "Rat", "refseq_name": "tRNA (34-2'-O)-methyltransferase regulator WDR6", "refseq_ac": [ { "id": "NP_001006989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006989", "type": "external" } ], "gene_names_uniprotkb": "Wdr6", "gene_names_refseq": "Wdr6", "protein_names_uniprotkb": "tRNA (34-2'-O)-methyltransferase regulator WDR6; WD repeat-containing protein 6", "protein_names_refseq": "WD repeat domain 6 protein; WD repeat-containing protein 6; tRNA (34-2'-O)-methyltransferase regulator WDR6", "tax_id": 10116, "disease": "", "pathway": " (rno:301007); (R-RNO-9013420); (R-RNO-9013424); (R-RNO-9696264); (R-RNO-9696270); (R-RNO-9696273)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "17720279", "class_list": "", "function": "Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (By similarity). Required for the correct positioning of the substrate tRNA for methylation (By similarity). Required to suppress amino acid starvation-induced autophagy (By similarity). Enhances the STK11/LKB1-induced cell growth suppression activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0030234 enzyme regulator activity;GO:0043560 insulin receptor substrate binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0010507 negative regulation of autophagy;GO:0008286 insulin receptor signaling pathway;GO:0030488 tRNA methylation;GO:0048009 insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XFW6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IN38-1", "uniprot_id": [ { "id": "WIF1_RAT", "url": "https://www.uniprot.org/uniprot/Q6IN38", "type": "external" } ], "mass": 41585.0, "length": 379, "protein_name": "Wnt inhibitory factor 1", "gene_name": "Wif1", "organism": "Rat", "refseq_name": "wnt inhibitory factor 1 precursor", "refseq_ac": [ { "id": "NP_001386439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386439", "type": "external" } ], "gene_names_uniprotkb": "Wif1", "gene_names_refseq": "Wif1", "protein_names_uniprotkb": "Wnt inhibitory factor 1; WIF-1", "protein_names_refseq": "WIF-1; wnt inhibitory factor 1 precursor", "tax_id": 10116, "disease": "small cell carcinoma (Disease Ontology:DOID:0050685); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); invasive ductal carcinoma (Disease Ontology:DOID:3008); renal cell carcinoma (Disease Ontology:DOID:4450)", "pathway": " (rno:114557)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12065666;12470708;19621428;21986617;26637809;29393594", "class_list": "", "function": "Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation., [UniProtKB, UniProtKB, UniProtKB]; Data show that microRNA miR-17-5p over-expression promoted the activation of hepatic stellate cell (HSC) and contributed to the reduction of Wnt inhibitory factor 1 (WIF1) levels., [RefSeq, PubMed]; Downregulation of Smad1/Wif1 gene expression may contribute to pulmonary hypoplasia in the nitrofen CDH model by retardation of lung development during saccular stage., [RefSeq, PubMed]; GLT mRNA was translated in Wnt-1-expressing C6 cells when the GLT mRNA required no splicing before translation occurred, [RefSeq, PubMed]; Wif-1 inhibits proliferation of neoplastic choroid plexus epithelial cells, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q924Y6", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0045600 positive regulation of fat cell differentiation;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6IN38-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIR9-1", "uniprot_id": [ { "id": "UBAC1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIR9", "type": "external" } ], "mass": 45546.0, "length": 409, "protein_name": "Ubiquitin-associated domain-containing protein 1", "gene_name": "Ubac1", "organism": "Rat", "refseq_name": "ubiquitin-associated domain-containing protein 1", "refseq_ac": [ { "id": "NP_001007743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007743", "type": "external" } ], "gene_names_uniprotkb": "Ubac1; Kpc2; Ubadc1", "gene_names_refseq": "Ubac1; Ubadc1", "protein_names_uniprotkb": "Ubiquitin-associated domain-containing protein 1; E3 ubiquitin-protein ligase subunit KPC2; Kip1 ubiquitination-promoting complex protein 2; UBA domain-containing protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase subunit KPC2; UBA domain-containing protein 1; kip1 ubiquitination-promoting complex protein 2; ubiquitin associated domain containing 1; ubiquitin-associated domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362087); (R-RNO-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16641100", "class_list": "", "function": "Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1. The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor. Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MFZ5-1", "uniprot_id": [ { "id": "TRI39_RAT", "url": "https://www.uniprot.org/uniprot/Q6MFZ5", "type": "external" } ], "mass": 56394.0, "length": 488, "protein_name": "E3 ubiquitin-protein ligase TRIM39", "gene_name": "Rpp21; Trim39", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM39", "refseq_ac": [ { "id": "NP_998727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998727", "type": "external" } ], "gene_names_uniprotkb": "Rpp21; Trim39; Rnf23; Rpp21", "gene_names_refseq": "Rnf23; Trim39", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM39; 2.3.2.27; RING finger protein 23; RING-type E3 ubiquitin transferase TRIM39; Tripartite motif-containing protein 39", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM39; RING finger protein 23; RING-type E3 ubiquitin transferase TRIM39; tripartite motif protein 39; tripartite motif-containing protein 39", "tax_id": 10116, "disease": "", "pathway": " (rno:309591); (rno:406230); (R-RNO-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similarity)., [UniProtKB, UniProtKB]; E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0033204 ribonuclease P RNA binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005655 nucleolar ribonuclease P complex", "go_biological_process": "GO:0045087 innate immune response;GO:0006915 apoptotic process;GO:2001235 positive regulation of apoptotic signaling pathway;GO:0050821 protein stabilization;GO:0043124 negative regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MFZ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7T9-1", "uniprot_id": [ { "id": "THNS2_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7T9", "type": "external" } ], "mass": 54137.0, "length": 485, "protein_name": "Threonine synthase-like 2", "gene_name": "Thnsl2", "organism": "Rat", "refseq_name": "threonine synthase-like 2", "refseq_ac": [ { "id": "NP_001009658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009658", "type": "external" } ], "gene_names_uniprotkb": "Thnsl2", "gene_names_refseq": "RGD1309144; Thnsl2; Tsh2", "protein_names_uniprotkb": "Threonine synthase-like 2; 4.2.3.-; TSH2", "protein_names_refseq": "threonine synthase-like 2", "tax_id": 10116, "disease": "", "pathway": " (rno:297332)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0016829 lyase activity;GO:0016791 phosphatase activity;GO:0070905 serine binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7T9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64560-1", "uniprot_id": [ { "id": "TPP2_RAT", "url": "https://www.uniprot.org/uniprot/Q64560", "type": "external" } ], "mass": 138293.0, "length": 1249, "protein_name": "Tripeptidyl-peptidase 2", "gene_name": "Tpp2", "organism": "Rat", "refseq_name": "tripeptidyl-peptidase 2", "refseq_ac": [ { "id": "NP_112399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112399", "type": "external" } ], "gene_names_uniprotkb": "Tpp2", "gene_names_refseq": "TPP-2; Tpp2", "protein_names_uniprotkb": "Tripeptidyl-peptidase 2; 3.4.14.10; TPP-2; TPP-II; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase II", "protein_names_refseq": "TPP-II; tripeptidyl aminopeptidase; tripeptidyl-peptidase 2; tripeptidyl-peptidase II", "tax_id": 10116, "disease": "primary immunodeficiency disease (Disease Ontology:DOID:612)", "pathway": " (rno:81815); (R-RNO-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12147224;25095668;8602240", "class_list": "", "function": "Changes in the activity of TPP II play an important role in the pathogenesis of blood vessels wall in atherosclerosis and arterial hypertension., [RefSeq, PubMed]; Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis (By similarity). Stimulates adipogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Increase of expression and activity in skeletal muscle during sepsis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.14", "type": "external" }, { "id": "3.4.22.40", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.40", "type": "external" }, { "id": "3.4.11.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.3", "type": "external" }, { "id": "3.4.14.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.10", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0008240 tripeptidyl-peptidase activity;GO:0004177 aminopeptidase activity;GO:0042277 peptide binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006508 proteolysis;GO:0030163 protein catabolic process;GO:0080144 intracellular amino acid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q64560-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GH59-1", "uniprot_id": [ { "id": "XKR4_RAT", "url": "https://www.uniprot.org/uniprot/Q5GH59", "type": "external" } ], "mass": 72716.0, "length": 647, "protein_name": "XK-related protein 4", "gene_name": "Xkr4", "organism": "Rat", "refseq_name": "XK-related protein 4", "refseq_ac": [ { "id": "NP_001011971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011971", "type": "external" } ], "gene_names_uniprotkb": "Xkr4; Xrg4", "gene_names_refseq": "XRG4; Xkr4", "protein_names_uniprotkb": "XK-related protein 4", "protein_names_refseq": "X Kell blood group precursor related family member 4; X-linked Kx blood group related 4; XK, Kell blood group complex subunit-related family, member 4; XK-related protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:297801)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0043652 engulfment of apoptotic cell;GO:0070782 phosphatidylserine exposure on apoptotic cell surface;GO:1902742 apoptotic process involved in development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5GH59-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE41-1", "uniprot_id": [ { "id": "WFDC9_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE41", "type": "external" } ], "mass": 8568.0, "length": 74, "protein_name": "Protein WFDC9", "gene_name": "Wfdc9", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wfdc9", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein WFDC9", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:408228)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE41-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI52-1", "uniprot_id": [ { "id": "VEZA_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI52", "type": "external" } ], "mass": 88694.0, "length": 782, "protein_name": "Vezatin", "gene_name": "Vezt", "organism": "Rat", "refseq_name": "vezatin", "refseq_ac": [ { "id": "NP_001006985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006985", "type": "external" } ], "gene_names_uniprotkb": "Vezt", "gene_names_refseq": "Vezt", "protein_names_uniprotkb": "Vezatin", "protein_names_refseq": "transmembrane protein vezatin; vezatin", "tax_id": 10116, "disease": "", "pathway": " (rno:299738)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017022 myosin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0043009 chordate embryonic development;GO:0060074 synapse maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI52-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EB63-1", "uniprot_id": [ { "id": "TM196_RAT", "url": "https://www.uniprot.org/uniprot/Q5EB63", "type": "external" } ], "mass": 18846.0, "length": 176, "protein_name": "Transmembrane protein 196", "gene_name": "Tmem196", "organism": "Rat", "refseq_name": "transmembrane protein 196 isoform 2", "refseq_ac": [ { "id": "NP_001037734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037734", "type": "external" } ], "gene_names_uniprotkb": "Tmem196", "gene_names_refseq": "RGD1562527; Tmem196", "protein_names_uniprotkb": "Transmembrane protein 196", "protein_names_refseq": "transmembrane protein 196 isoform 2", "tax_id": 10116, "disease": "", "pathway": " (rno:500750)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26056045", "class_list": "", "function": "Acts as a tumor suppressor in lung cancer. Inhibits tumor cell growth by inhibiting cell proliferation and migration and promoting cell apoptosis. Inhibits metastasis of lung cancer by suppressing beta-catenin expression in the Wnt/beta-catenin signaling pathway., [UniProtKB, UniProtKB, UniProtKB]; TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is an independent prognostic factor of lung cancer, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0030336 negative regulation of cell migration;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EB63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQQ2-1", "uniprot_id": [ { "id": "WBP11_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQQ2", "type": "external" } ], "mass": 69996.0, "length": 641, "protein_name": "WW domain-binding protein 11", "gene_name": "Wbp11", "organism": "Rat", "refseq_name": "WW domain-binding protein 11", "refseq_ac": [ { "id": "NP_001009661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009661", "type": "external" } ], "gene_names_uniprotkb": "Wbp11; Sipp1; Wbp11l1", "gene_names_refseq": "Wbp11l1; Wbp11; wbp-11", "protein_names_uniprotkb": "WW domain-binding protein 11; Splicing factor that interacts with PQBP-1 and PP1; WBP-11", "protein_names_refseq": "WW domain-binding protein 11-like 1; WW domain-binding protein 11; splicing factor that interacts with PQBP-1 and PP1", "tax_id": 10116, "disease": "", "pathway": " (rno:297695); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0050699 WW domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0006364 rRNA processing;GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PQQ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY86-1", "uniprot_id": [ { "id": "VP26A_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY86", "type": "external" } ], "mass": 38115.0, "length": 327, "protein_name": "Vacuolar protein sorting-associated protein 26A", "gene_name": "Vps26a", "organism": "Rat", "refseq_name": "vacuolar protein sorting-associated protein 26A", "refseq_ac": [ { "id": "NP_001007741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007741", "type": "external" } ], "gene_names_uniprotkb": "Vps26a; Vps26", "gene_names_refseq": "Vps26a; Vps26", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 26A; Vesicle protein sorting 26A", "protein_names_refseq": "H beta 58; VPS26 retromer complex comonent A; vacuolar protein sorting 26 homolog A; vacuolar protein sorting-associated protein 26A; vacuole protein sorting 26; vesicle protein sorting 26A", "tax_id": 10116, "disease": "brain cancer (Disease Ontology:DOID:1319); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:361846); (R-RNO-3238698)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "22673903;26538661", "class_list": "", "function": "Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC complex seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2 (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Acts redundantly with VSP26B in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; VPS26A-SNX27 interaction plays a role in the development of neuropathic pain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030906 retromer, cargo-selective complex;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005764 lysosome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AY86-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q715S9-1", "uniprot_id": [ { "id": "NDK8_RAT", "url": "https://www.uniprot.org/uniprot/Q715S9", "type": "external" } ], "mass": 67312.0, "length": 587, "protein_name": "Protein NME8", "gene_name": "Nme8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nme8; Sptrx2; Txndc3", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein NME8; 2.7.-.-; 3.1.11.-; NDK8; NME/NM23 family member 8; Nucleoside diphosphate kinase 8; Protein kinase NME8; Putative 3'-5'-DNA exonuclease NDK8; Spermatid-specific thioredoxin-2; Sptrx-2; Thioredoxin domain-containing protein 3", "protein_names_refseq": "", "tax_id": 10116, "disease": "primary ciliary dyskinesia 6 (Disease Ontology:DOID:0110606)", "pathway": " (rno:364729)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12909633", "class_list": "", "function": "Possesses an intrinsic kinase activity. In vitro, does not exhibit nucleoside diphosphate kinase (NDPK) activity or disulfide bond-reducing activity. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, suggesting a role in DNA nucleolytic processing. May be required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0008017 microtubule binding;GO:0016740 transferase activity", "go_cellular_component": "GO:0097598 sperm cytoplasmic droplet;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005930 axoneme", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0060271 cilium assembly;GO:0034614 cellular response to reactive oxygen species;GO:0006308 DNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q715S9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M823-1", "uniprot_id": [ { "id": "NUDC2_RAT", "url": "https://www.uniprot.org/uniprot/Q5M823", "type": "external" } ], "mass": 17674.0, "length": 157, "protein_name": "NudC domain-containing protein 2", "gene_name": "Nudcd2", "organism": "Rat", "refseq_name": "nudC domain-containing protein 2", "refseq_ac": [ { "id": "NP_001009621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009621", "type": "external" } ], "gene_names_uniprotkb": "Nudcd2", "gene_names_refseq": "Nudcd2; RGD1307203", "protein_names_uniprotkb": "NudC domain-containing protein 2", "protein_names_refseq": "nudC domain-containing protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:287199)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0000776 kinetochore", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M823-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DGF8-1", "uniprot_id": [ { "id": "TMM18_RAT", "url": "https://www.uniprot.org/uniprot/Q6DGF8", "type": "external" } ], "mass": 16548.0, "length": 140, "protein_name": "Transmembrane protein 18", "gene_name": "Tmem18", "organism": "Rat", "refseq_name": "transmembrane protein 18", "refseq_ac": [ { "id": "NP_001007749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007749", "type": "external" } ], "gene_names_uniprotkb": "Tmem18", "gene_names_refseq": "Tmem18", "protein_names_uniprotkb": "Transmembrane protein 18", "protein_names_refseq": "transmembrane protein 18", "tax_id": 10116, "disease": "abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:362722)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18559506;21779089;21952719;29393594", "class_list": "", "function": "Long-Evans rats maintained on chow or a high-fat diet (HFD) for 6 weeks. From a total of 19 genes analyzed, seven genes (ETV5, FTO, GNPDA2, KCTD15, TMEM18, MC4R, and SH2B1) were down-regulated in the hypothalamus of HFD compared to chow-fed rats, [RefSeq, PubMed]; Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats (By similarity). Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC)., [UniProtKB, PubMed]; We observed a strong positive correlation between TMEM18 expression and body weight in the prefrontal cortex (PFC) (r = 0.5694, P = 0.0003) indicating a potential role for TMEM18 in higher functions related to feeding involving the PFC., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016477 cell migration;GO:0042755 eating behavior;GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6DGF8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQR8-1", "uniprot_id": [ { "id": "TPRKB_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQR8", "type": "external" } ], "mass": 17593.0, "length": 158, "protein_name": "EKC/KEOPS complex subunit Tprkb", "gene_name": "Tprkb", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tprkb", "gene_names_refseq": "", "protein_names_uniprotkb": "EKC/KEOPS complex subunit Tprkb; PRPK-binding protein; TP53RK-binding protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "Galloway-Mowat syndrome 5 (Disease Ontology:DOID:0080247)", "pathway": " (rno:297411)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQR8-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BKE0-1", "uniprot_id": [ { "id": "TAF9_RAT", "url": "https://www.uniprot.org/uniprot/Q5BKE0", "type": "external" } ], "mass": 28994.0, "length": 264, "protein_name": "Transcription initiation factor TFIID subunit 9", "gene_name": "Ak6; Taf9", "organism": "Rat", "refseq_name": "transcription initiation factor TFIID subunit 9", "refseq_ac": [ { "id": "NP_001032387", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032387", "type": "external" } ], "gene_names_uniprotkb": "Ak6; Taf9; AK6; Ak6; CINAP; Taf2g; Tafii31", "gene_names_refseq": "CINAP; TAFII31; TAFII32; Taf9", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 9; RNA polymerase II TBP-associated factor subunit G; TAFII-31; TAFII-32; TAFII31; TAFII32; Transcription initiation factor TFIID 31 kDa subunit; Transcription initiation factor TFIID 32 kDa subunit", "protein_names_refseq": "RNA polymerase II TBP-associated factor subunit G; TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAF9 RNA polymerase II, TATA box binding protein-associated factor; transcription initiation factor TFIID 31 kDa subunit; transcription initiation factor TFIID 32 kDa subunit; transcription initiation factor TFIID subunit 9", "tax_id": 10116, "disease": "", "pathway": " (rno:373541); (R-RNO-674695); (R-RNO-6804756); (R-RNO-6807505); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-76042)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "15309719", "class_list": "", "function": "Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. May be involved in regulation of Cajal body (CB) formation., [UniProtKB, HAMAP, UniProtKB, UniProtKB]; The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. Essential for cell viability. May have a role in gene regulation associated with apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6UV34;Q7TP20", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0051117 ATPase binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071339 MLL1 complex;GO:0070761 pre-snoRNP complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0060760 positive regulation of response to cytokine stimulus;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BKE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63525-1", "uniprot_id": [ { "id": "NUDC_RAT", "url": "https://www.uniprot.org/uniprot/Q63525", "type": "external" } ], "mass": 38412.0, "length": 332, "protein_name": "Nuclear migration protein nudC", "gene_name": "Nudc", "organism": "Rat", "refseq_name": "nuclear migration protein nudC", "refseq_ac": [ { "id": "NP_058967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058967", "type": "external" } ], "gene_names_uniprotkb": "Nudc", "gene_names_refseq": "Nudc; Silg92; c15", "protein_names_uniprotkb": "Nuclear migration protein nudC; Nuclear distribution protein C homolog; c15", "protein_names_refseq": "clone 15; nuclear distribution C homolog; nuclear distribution gene C homolog; nuclear distribution protein C homolog; nuclear migration protein nudC-like; nuclear migration protein nudC; nudC nuclear distribution protein", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:29648); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025); (R-RNO-9696270)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "21771589;7776977;9601647", "class_list": "", "function": "NudC, like Lis1, is required for neuronal migration during neocorticogenesis., [RefSeq, PubMed]; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity). Necessary for cytokinesis and cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030496 midbody;GO:0072686 mitotic spindle", "go_biological_process": "GO:0051301 cell division;GO:0006457 protein folding;GO:0007080 mitotic metaphase chromosome alignment;GO:0043434 response to peptide hormone;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63525-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62969-1", "uniprot_id": [ { "id": "PTGIS_RAT", "url": "https://www.uniprot.org/uniprot/Q62969", "type": "external" } ], "mass": 57128.0, "length": 501, "protein_name": "Prostacyclin synthase", "gene_name": "AABR07054614.1; Ptgis", "organism": "Rat", "refseq_name": "prostacyclin synthase", "refseq_ac": [ { "id": "NP_113745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113745", "type": "external" } ], "gene_names_uniprotkb": "AABR07054614.1; Ptgis; AABR07054614.1; Cyp8; Ptgis", "gene_names_refseq": "PGIS; Ptgis", "protein_names_uniprotkb": "Prostacyclin synthase; 4.2.1.152; 5.3.99.4; Hydroperoxy icosatetraenoate dehydratase; Prostaglandin I2 synthase", "protein_names_refseq": "hydroperoxy icosatetraenoate dehydratase; prostacyclin synthase; prostaglandin I2 (prostacyclin) synthase", "tax_id": 10116, "disease": "limb ischemia (Disease Ontology:DOID:0050852); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); UV-sensitive syndrome (Disease Ontology:DOID:0060240); colorectal carcinoma (Disease Ontology:DOID:0080199); cerebral cavernous malformation 1 (Disease Ontology:DOID:0080491); primary ovarian insufficiency 11 (Disease Ontology:DOID:0080868); Cockayne syndrome B (Disease Ontology:DOID:0080908); cerebrooculofacioskeletal syndrome 1 (Disease Ontology:DOID:0080911); age related macular degeneration 5 (Disease Ontology:DOID:0110028); De Sanctis-Cacchione syndrome (Disease Ontology:DOID:0112158); stomach cancer (Disease Ontology:DOID:10534); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); carotid stenosis (Disease Ontology:DOID:13001); lung cancer (Disease Ontology:DOID:1324); patent ductus arteriosus (Disease Ontology:DOID:13832); polyneuropathy due to drug (Disease Ontology:DOID:14184); Parkinson's disease (Disease Ontology:DOID:14330); primary pulmonary hypertension (Disease Ontology:DOID:14557); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); larynx cancer (Disease Ontology:DOID:2596); Cockayne syndrome (Disease Ontology:DOID:2962); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); macular degeneration (Disease Ontology:DOID:4448); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25527); (R-RNO-211979); (R-RNO-2162123)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152", "type": "external" }, { "id": "5.4.4.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.4.7", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.1", "type": "external" }, { "id": "5.3.99.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5", "type": "external" }, { "id": "5.3.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.4", "type": "external" } ], "go_molecular_function": "GO:0008116 prostaglandin-I synthase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0043279 response to alkaloid;GO:0006690 icosanoid metabolic process;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q62969-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHM3-1", "uniprot_id": [ { "id": "T53I2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CHM3", "type": "external" } ], "mass": 21624.0, "length": 199, "protein_name": "Tumor protein p53-inducible nuclear protein 2", "gene_name": "Tp53inp2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tp53inp2; Dor; Trp53inp2", "gene_names_refseq": "", "protein_names_uniprotkb": "Tumor protein p53-inducible nuclear protein 2; Diabetes and obesity-regulated gene", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:362246)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18030323", "class_list": "", "function": "Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0016605 PML body", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006351 DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CHM3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6DGG0-1", "uniprot_id": [ { "id": "PPID_RAT", "url": "https://www.uniprot.org/uniprot/Q6DGG0", "type": "external" } ], "mass": 40766.0, "length": 370, "protein_name": "Peptidyl-prolyl cis-trans isomerase D", "gene_name": "Ppidl1; Ppid", "organism": "Rat", "refseq_name": "peptidyl-prolyl cis-trans isomerase D", "refseq_ac": [ { "id": "NP_001004279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004279", "type": "external" } ], "gene_names_uniprotkb": "Ppidl1; Ppid; Ppidl1", "gene_names_refseq": "Cyp-40; CypD; Ppid", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase D; 40 kDa peptidyl-prolyl cis-trans isomerase; 5.2.1.8; CYP-40; Cyclophilin-40; PPIase D; Rotamase D", "protein_names_refseq": "40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin D; PPIase D; cyclophilin-40; peptidyl-prolyl cis-trans isomerase D; rotamase D", "tax_id": 10116, "disease": "", "pathway": " (rno:361967); (rno:501204); (R-RNO-8939211)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "21332552;22647578;25617357", "class_list": "", "function": "In cardiomyocytes the protective effects of metformin-induced AMPK activation against oxidative stress converge on mitochondria and are mediated, at least in part, through the dissociation of PPARalpha-CypD interactions., [RefSeq, PubMed]; NIM811 attenuates liver fibrosis in a CCl(4)-induced rat liver fibrosis model, which may be related to binding with cyclophilin B and D., [RefSeq, PubMed]; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ppid expression was predicted by plasma estradiol & 34% lower in control adolescent females than males. After chronic adolescent stress, females had elevated hippocampal Ppid expression that was not seen in males., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0031072 heat shock protein binding;GO:0008134 transcription factor binding;GO:0030331 nuclear estrogen receptor binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006979 response to oxidative stress;GO:0015031 protein transport;GO:0043065 positive regulation of apoptotic process;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6DGG0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71UF4-1", "uniprot_id": [ { "id": "RBBP7_RAT", "url": "https://www.uniprot.org/uniprot/Q71UF4", "type": "external" } ], "mass": 47820.0, "length": 425, "protein_name": "Histone-binding protein RBBP7", "gene_name": "Rbbp4; Rbbp7", "organism": "Rat", "refseq_name": "histone-binding protein RBBP7", "refseq_ac": [ { "id": "NP_114004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114004", "type": "external" } ], "gene_names_uniprotkb": "Rbbp4; Rbbp7; Rbbp4l1; Rbbp4", "gene_names_refseq": "Rbbp7", "protein_names_uniprotkb": "Histone-binding protein RBBP7; Nucleosome-remodeling factor subunit RBAP46; RBBP-7; Retinoblastoma-binding protein 7", "protein_names_refseq": "RBBP-7; histone-binding protein RBBP7; nucleosome-remodeling factor subunit RBAP46; retinoblastoma-binding protein 7", "tax_id": 10116, "disease": "X-linked spermatogenic failure 9 (Disease Ontology:DOID:0061177); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (rno:83712); (R-RNO-212300); (R-RNO-2559580); (R-RNO-3214815); (R-RNO-3214841); (R-RNO-3214847); (R-RNO-3214858); (R-RNO-606279); (R-RNO-6804758); (R-RNO-73762); (R-RNO-8943724); (R-RNO-8951664); (R-RNO-8953750); (R-RNO-9764725); (R-RNO-9909649); (R-RNO-9937850); (R-RNO-9940951)", "pathway_count": 17, "publication_count": 1, "publication_id_list": "24991957", "class_list": "", "function": "Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Endogenous Mta1/2 forms a complex with chromodomain helicase (Chd)4, histone deacetylase (Hdac)1/2, RbAp46/48, and Mbd3 in the rat cerebellum, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042393 histone binding;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035098 ESC/E(Z) complex;GO:0016589 NURF complex;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q71UF4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63312-1", "uniprot_id": [ { "id": "PHLB1_RAT", "url": "https://www.uniprot.org/uniprot/Q63312", "type": "external" } ], "mass": 93541.0, "length": 831, "protein_name": "Pleckstrin homology-like domain family B member 1", "gene_name": "Phldb1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Phldb1; Ll5", "gene_names_refseq": "", "protein_names_uniprotkb": "Pleckstrin homology-like domain family B member 1; Protein LL5-alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "osteogenesis imperfecta (Disease Ontology:DOID:12347)", "pathway": " (rno:171434)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22673903;38843836;8241284", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045180 basal cortex", "go_biological_process": "GO:0071711 basement membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63312-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVH8-1", "uniprot_id": [ { "id": "R7BP_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVH8", "type": "external" } ], "mass": 28966.0, "length": 257, "protein_name": "Regulator of G protein signaling 7-binding protein", "gene_name": "Rgs7bp", "organism": "Rat", "refseq_name": "regulator of G-protein signaling 7-binding protein", "refseq_ac": [ { "id": "NP_001012347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012347", "type": "external" } ], "gene_names_uniprotkb": "Rgs7bp; R7bp", "gene_names_refseq": "R7bp; RGD1309360; Rgs7bp", "protein_names_uniprotkb": "Regulator of G protein signaling 7-binding protein; R7 family-binding protein", "protein_names_refseq": "R7 binding protein; R7 family-binding protein; regulator of G-protein signaling 7-binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:294715)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21343290", "class_list": "", "function": "Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction;GO:0060078 regulation of postsynaptic membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5FVH8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIF9-1", "uniprot_id": [ { "id": "S2534_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIF9", "type": "external" } ], "mass": 33652.0, "length": 318, "protein_name": "Solute carrier family 25 member 34", "gene_name": "Slc25a34; Tmem82", "organism": "Rat", "refseq_name": "solute carrier family 25 member 34", "refseq_ac": [ { "id": "NP_001013958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013958", "type": "external" } ], "gene_names_uniprotkb": "Slc25a34; Tmem82", "gene_names_refseq": "Slc25a34", "protein_names_uniprotkb": "Solute carrier family 25 member 34", "protein_names_refseq": "solute carrier family 25 member 34", "tax_id": 10116, "disease": "", "pathway": " (rno:298606)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0001835 blastocyst hatching", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIF9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQM0-1", "uniprot_id": [ { "id": "TM168_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQM0", "type": "external" } ], "mass": 79772.0, "length": 697, "protein_name": "Transmembrane protein 168", "gene_name": "Tmem168", "organism": "Rat", "refseq_name": "transmembrane protein 168", "refseq_ac": [ { "id": "NP_001014076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014076", "type": "external" } ], "gene_names_uniprotkb": "Tmem168", "gene_names_refseq": "RGD1307778; Tmem168", "protein_names_uniprotkb": "Transmembrane protein 168", "protein_names_refseq": "transmembrane protein 168", "tax_id": 10116, "disease": "", "pathway": " (rno:312135)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A. May play a role i the modulation of anxiety behavior by regulating GABAergic neuronal system in the nucleus accumbens., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0030133 transport vesicle", "go_biological_process": "GO:1905150 regulation of voltage-gated sodium channel activity;GO:2000058 regulation of ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQM0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q710E6-1", "uniprot_id": [ { "id": "SUCO_RAT", "url": "https://www.uniprot.org/uniprot/Q710E6", "type": "external" } ], "mass": 139260.0, "length": 1253, "protein_name": "SUN domain-containing ossification factor", "gene_name": "Suco", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Suco; Dd25; Opt", "gene_names_refseq": "", "protein_names_uniprotkb": "SUN domain-containing ossification factor; Membrane protein CH1; Protein osteopotentia homolog; SUN-like protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "osteogenesis imperfecta type 5 (Disease Ontology:DOID:0110344)", "pathway": " (rno:360863)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0016020 membrane;GO:0030867 rough endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0032967 positive regulation of collagen biosynthetic process;GO:0045669 positive regulation of osteoblast differentiation;GO:0001503 ossification;GO:0046850 regulation of bone remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q710E6-1", "record_type": "protein", "filter_code": "0000000.0000011.010000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQQ4-1", "uniprot_id": [ { "id": "PIGC_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQQ4", "type": "external" } ], "mass": 33666.0, "length": 297, "protein_name": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "gene_name": "Pigc", "organism": "Rat", "refseq_name": "phosphatidylinositol N-acetylglucosaminyltransferase subunit C", "refseq_ac": [ { "id": "NP_001012207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012207", "type": "external" } ], "gene_names_uniprotkb": "Pigc", "gene_names_refseq": "Pigc", "protein_names_uniprotkb": "Phosphatidylinositol N-acetylglucosaminyltransferase subunit C; PIG-C; Phosphatidylinositol-glycan biosynthesis class C protein", "protein_names_refseq": "PIG-C; phosphatidylinositol N-acetylglucosaminyltransferase subunit C; phosphatidylinositol glycan, class C; phosphatidylinositol-glycan biosynthesis class C protein", "tax_id": 10116, "disease": "glycosylphosphatidylinositol biosynthesis defect 16 (Disease Ontology:DOID:0081223)", "pathway": " (rno:364032); (R-RNO-162710)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQQ4-1", "record_type": "protein", "filter_code": "0000000.1000011.100000.000000000000001000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HR0-1", "uniprot_id": [ { "id": "S12A9_RAT", "url": "https://www.uniprot.org/uniprot/Q66HR0", "type": "external" } ], "mass": 96005.0, "length": 914, "protein_name": "Solute carrier family 12 member 9", "gene_name": "Slc12a9", "organism": "Rat", "refseq_name": "solute carrier family 12 member 9", "refseq_ac": [ { "id": "NP_599232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599232", "type": "external" } ], "gene_names_uniprotkb": "Slc12a9; Ccc6", "gene_names_refseq": "Ccc6; Cip1; Slc12a9", "protein_names_uniprotkb": "Solute carrier family 12 member 9; Cation-chloride cotransporter 6", "protein_names_refseq": "cation-chloride cotransporter 6; cation-chloride cotransporter-interacting protein 1; solute carrier family 12 (potassium/chloride transporters), member 9; solute carrier family 12 member 9", "tax_id": 10116, "disease": "", "pathway": " (rno:171443)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21454685;22673903;38843836", "class_list": "", "function": "May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function. May play a role in lysosomal ion flux and osmoregulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q99NC8", "ec_number_list": [], "go_molecular_function": "GO:0015379 potassium:chloride symporter activity;GO:0015377 chloride:monoatomic cation symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis;GO:0055064 chloride ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q66HR0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q69BT7-1", "uniprot_id": [ { "id": "TPPC4_RAT", "url": "https://www.uniprot.org/uniprot/Q69BT7", "type": "external" } ], "mass": 24359.0, "length": 219, "protein_name": "Trafficking protein particle complex subunit 4", "gene_name": "Trappc4", "organism": "Rat", "refseq_name": "trafficking protein particle complex subunit 4", "refseq_ac": [ { "id": "NP_001003708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003708", "type": "external" } ], "gene_names_uniprotkb": "Trappc4; Sbdn", "gene_names_refseq": "Sbdn; Trappc4", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 4; Synbindin", "protein_names_refseq": "synbindin; trafficking protein particle complex 4; trafficking protein particle complex subunit 4", "tax_id": 10116, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)", "pathway": " (rno:367073); (R-RNO-204005); (R-RNO-8876198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (By similarity). May play a role in dendrite postsynaptic membrane trafficking (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4G098", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0030425 dendrite;GO:0045202 synapse;GO:0048786 presynaptic active zone", "go_biological_process": "GO:0016358 dendrite development;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q69BT7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63754-1", "uniprot_id": [ { "id": "SYUB_RAT", "url": "https://www.uniprot.org/uniprot/Q63754", "type": "external" } ], "mass": 14504.0, "length": 137, "protein_name": "Beta-synuclein", "gene_name": "Sncb", "organism": "Rat", "refseq_name": "beta-synuclein isoform 1", "refseq_ac": [ { "id": "NP_542955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542955", "type": "external" } ], "gene_names_uniprotkb": "Sncb", "gene_names_refseq": "Sncb", "protein_names_uniprotkb": "Beta-synuclein; PNP 14; Phosphoneuroprotein 14", "protein_names_refseq": "PNP 14; beta-synuclein isoform 1; beta-synuclein; phosphoneuroprotein 14", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Pick's disease (Disease Ontology:DOID:11870); Lewy body dementia (Disease Ontology:DOID:12217); uveitis (Disease Ontology:DOID:13141); Parkinson's disease (Disease Ontology:DOID:14330); pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981); acute megakaryocytic leukemia (Disease Ontology:DOID:8761)", "pathway": " (rno:113893)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11739622;1402909;19692427;22673903;29808713;30787438;33428933;8223629", "class_list": "", "function": "May be involved in neuronal plasticity., [UniProtKB]; T cells directed against the neuronal protein beta-synuclein specifically invade the grey matter and is accompanied by the presentation of multifaceted clinical disease; findings reveal a previously unrecognized role of beta-synuclein in provoking T-cell-mediated pathology of the central nervous system Erratum:[Nature. 2019 Mar;567(7749):E15. doi: 10.1038/s41586-019-1047-0. PMID: 30867589], [RefSeq, PubMed]; Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons., [RefSeq, PubMed]; The aim of this study was to elucidate the age-dependent role of Sncb in brain microvascular endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5PPN9", "ec_number_list": [], "go_molecular_function": "GO:0046914 transition metal ion binding;GO:0005509 calcium ion binding;GO:0048487 beta-tubulin binding;GO:0043014 alpha-tubulin binding;GO:1903136 cuprous ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030426 growth cone;GO:0043025 neuronal cell body;GO:0043195 terminal bouton;GO:0043679 axon terminus", "go_biological_process": "GO:0050808 synapse organization;GO:0007268 chemical synaptic transmission;GO:0043524 negative regulation of neuron apoptotic process;GO:0042417 dopamine metabolic process;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q63754-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IN02-1", "uniprot_id": [ { "id": "PR15A_RAT", "url": "https://www.uniprot.org/uniprot/Q6IN02", "type": "external" } ], "mass": 63570.0, "length": 578, "protein_name": "Protein phosphatase 1 regulatory subunit 15A", "gene_name": "Ppp1r15a", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 15A", "refseq_ac": [ { "id": "NP_598230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598230", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r15a; Gadd34; Myd116; Peg3", "gene_names_refseq": "Gadd34; Myd116; Peg-3; Ppp1r15a; RGD1624209", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 15A; Growth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116 homolog; PEG-3; Progression elevated gene 3 protein", "protein_names_refseq": "growth arrest and DNA damage-inducible protein GADD34; myeloid differentiation primary response gene 116; myeloid differentiation primary response protein MyD116 homolog; progression elevated gene 3 protein; protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); thalassemia (Disease Ontology:DOID:10241); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316)", "pathway": " (rno:171071)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10611347;12813455;15674324;34098025;8139541;9256446", "class_list": "", "function": "Growth arrest and DNA damage-inducible protein 34 (GADD34) contributes to cerebral ischemic injury and can be detected in plasma exosomes., [RefSeq, PubMed]; Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88344;Q7TQC2", "ec_number_list": [], "go_molecular_function": "GO:0071074 eukaryotic initiation factor eIF2 binding;GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0019888 protein phosphatase regulator activity;GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0032058 positive regulation of translational initiation in response to stress;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001934 positive regulation of protein phosphorylation;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6IN02-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIC4-1", "uniprot_id": [ { "id": "SPG21_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIC4", "type": "external" } ], "mass": 29576.0, "length": 261, "protein_name": "Maspardin", "gene_name": "Spg21", "organism": "Rat", "refseq_name": "maspardin isoform 3", "refseq_ac": [ { "id": "NP_001006988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006988", "type": "external" } ], "gene_names_uniprotkb": "Spg21", "gene_names_refseq": "Spg21", "protein_names_uniprotkb": "Maspardin; Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog", "protein_names_refseq": "SPG21, maspardin; acid cluster protein 33; maspardin isoform 3; maspardin; spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog; spastic paraplegia 21 homolog-like", "tax_id": 10116, "disease": "Mast syndrome (Disease Ontology:DOID:0060245); hereditary spastic paraplegia (Disease Ontology:DOID:2476)", "pathway": " (rno:300791)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role as a negative regulatory factor in CD4-dependent T-cell activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042609 CD4 receptor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030140 trans-Golgi network transport vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0007626 locomotory behavior;GO:0050905 neuromuscular process;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0048668 collateral sprouting;GO:0060173 limb development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIC4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M844-1", "uniprot_id": [ { "id": "SYNE4_RAT", "url": "https://www.uniprot.org/uniprot/Q5M844", "type": "external" } ], "mass": 36515.0, "length": 340, "protein_name": "Nesprin-4", "gene_name": "Syne4", "organism": "Rat", "refseq_name": "nesprin-4 isoform 2", "refseq_ac": [ { "id": "NP_001009283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009283", "type": "external" } ], "gene_names_uniprotkb": "Syne4; Syne4l1", "gene_names_refseq": "KASH4; RGD1304580; Syne4l1; Syne4", "protein_names_uniprotkb": "Nesprin-4; KASH domain-containing protein 4; KASH4; Nuclear envelope spectrin repeat protein 4", "protein_names_refseq": "KASH domain-containing protein 4; KASH domain-containing protein C19orf46 homolog; nesprin-4 isoform 2; nesprin-4; nuclear envelope spectrin repeat protein 4; spectrin repeat containing, nuclear envelope family member 4-like 1", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 76 (Disease Ontology:DOID:0110524)", "pathway": " (rno:292781)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology, by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005640 nuclear outer membrane;GO:0034993 meiotic nuclear membrane microtubule tethering complex", "go_biological_process": "GO:0045198 establishment of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M844-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNK6-1", "uniprot_id": [ { "id": "TRM11_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNK6", "type": "external" } ], "mass": 53103.0, "length": 463, "protein_name": "tRNA (guanine(10)-N(2))-methyltransferase TRMT11", "gene_name": "Trmt11", "organism": "Rat", "refseq_name": "tRNA (guanine(10)-N(2))-methyltransferase TRMT11 isoform 1", "refseq_ac": [ { "id": "NP_932168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932168", "type": "external" } ], "gene_names_uniprotkb": "Trmt11", "gene_names_refseq": "Mds024; Trmt11", "protein_names_uniprotkb": "tRNA (guanine(10)-N(2))-methyltransferase TRMT11; 2.1.1.214; tRNA methyltransferase 11 homolog", "protein_names_refseq": "putative RNA methylase MDS024; tRNA (guanine(10)-N(2))-methyltransferase TRMT11 isoform 1; tRNA (guanine(10)-N(2))-methyltransferase TRMT11; tRNA (guanine(10)-N(2))-methyltransferase homolog; tRNA (guanine(10)-N2)-methyltransferase homolog; tRNA guanosine-2'-O-methyltransferase TRM11 homolog; tRNA methyltransferase 11 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:378794)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.214", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.214", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0008168 methyltransferase activity;GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0034708 methyltransferase complex;GO:0043528 tRNA (m2G10) methyltransferase complex;GO:0043527 tRNA methyltransferase complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TNK6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJR8-1", "uniprot_id": [ { "id": "RXRG_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJR8", "type": "external" } ], "mass": 50893.0, "length": 463, "protein_name": "Retinoic acid receptor RXR-gamma", "gene_name": "Rxrg", "organism": "Rat", "refseq_name": "retinoic acid receptor RXR-gamma", "refseq_ac": [ { "id": "NP_113953", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113953", "type": "external" } ], "gene_names_uniprotkb": "Rxrg; Nr2b3", "gene_names_refseq": "Rxrg", "protein_names_uniprotkb": "Retinoic acid receptor RXR-gamma; Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma", "protein_names_refseq": "RXR gamma-1; nuclear receptor subfamily 2 group B member 3; retinoic X receptor gamma-1; retinoic acid receptor RXR-gamma-like; retinoic acid receptor RXR-gamma", "tax_id": 10116, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (rno:83574); (R-RNO-383280); (R-RNO-5362517)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1312497;23017197;28267642;30015907", "class_list": "", "function": "RXRgamma was absent in the female rat brain, while it was observed in some regions in the male., [RefSeq, PubMed]; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)., [UniProtKB]; The results of the present study revealed that miR3305p acts as a critical regulator of RXRgamma, and is able to determinate the fate of MSCs to differentiate into adipocytes. This suggests that miR3305p and RXRgamma may be target molecules for controlling metabolic diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003707 nuclear steroid receptor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5BJR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811P6-1", "uniprot_id": [ { "id": "TFB1M_RAT", "url": "https://www.uniprot.org/uniprot/Q811P6", "type": "external" } ], "mass": 39181.0, "length": 345, "protein_name": "Dimethyladenosine transferase 1, mitochondrial", "gene_name": "Tfb1m", "organism": "Rat", "refseq_name": "dimethyladenosine transferase 1, mitochondrial", "refseq_ac": [ { "id": "NP_852139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_852139", "type": "external" } ], "gene_names_uniprotkb": "Tfb1m", "gene_names_refseq": "Tfb1m", "protein_names_uniprotkb": "Dimethyladenosine transferase 1, mitochondrial; 2.1.1.-; Mitochondrial 12S rRNA dimethylase 1; Mitochondrial transcription factor B1; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1; mtTFB1", "protein_names_refseq": "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1; dimethyladenosine transferase 1, mitochondrial; mitochondrial 12S rRNA dimethylase 1; mitochondrial transcription factor B1; mtTFB1", "tax_id": 10116, "disease": "", "pathway": " (rno:308140)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IRI6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0034246 mitochondrial transcription factor activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0031167 rRNA methylation;GO:0006391 transcription initiation at mitochondrial promoter;GO:0180026 mitochondrial small ribosomal subunit assembly;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q811P6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P799-1", "uniprot_id": [ { "id": "SYSC_RAT", "url": "https://www.uniprot.org/uniprot/Q6P799", "type": "external" } ], "mass": 58588.0, "length": 512, "protein_name": "Serine--tRNA ligase, cytoplasmic", "gene_name": "Sars1", "organism": "Rat", "refseq_name": "serine--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_001007607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007607", "type": "external" } ], "gene_names_uniprotkb": "Sars1; Sars", "gene_names_refseq": "Sars1; Sars", "protein_names_uniprotkb": "Serine--tRNA ligase, cytoplasmic; 6.1.1.11; SerRS; Seryl-tRNA synthetase; Seryl-tRNA(Ser/Sec) synthetase", "protein_names_refseq": "serRS; serine--tRNA ligase, cytoplasmic; seryl-aminoacyl-tRNA synthetase 1; seryl-tRNA synthetase, cytoplasmic; seryl-tRNA(Ser/Sec) synthetase", "tax_id": 10116, "disease": "arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); prostate carcinoma (Disease Ontology:DOID:10286); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (rno:266975)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CIQ8", "ec_number_list": [ { "id": "6.1.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.11", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043527 tRNA methyltransferase complex", "go_biological_process": "GO:0001514 selenocysteine incorporation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006400 tRNA modification;GO:0016525 negative regulation of angiogenesis;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P799-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1W2-1", "uniprot_id": [ { "id": "PRR13_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1W2", "type": "external" } ], "mass": 14334.0, "length": 139, "protein_name": "Proline-rich protein 13", "gene_name": "Prr13", "organism": "Rat", "refseq_name": "proline-rich protein 13", "refseq_ac": [ { "id": "NP_001008380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008380", "type": "external" } ], "gene_names_uniprotkb": "Prr13", "gene_names_refseq": "Prr13; RGD1307129", "protein_names_uniprotkb": "Proline-rich protein 13", "protein_names_refseq": "proline-rich protein 13", "tax_id": 10116, "disease": "", "pathway": " (rno:363004)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U1W2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RK27-1", "uniprot_id": [ { "id": "S12A7_RAT", "url": "https://www.uniprot.org/uniprot/Q5RK27", "type": "external" } ], "mass": 119378.0, "length": 1083, "protein_name": "Solute carrier family 12 member 7", "gene_name": "Slc12a7", "organism": "Rat", "refseq_name": "solute carrier family 12 member 7", "refseq_ac": [ { "id": "NP_001013162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013162", "type": "external" } ], "gene_names_uniprotkb": "Slc12a7; Kcc4", "gene_names_refseq": "Kcc4; Slc12a7", "protein_names_uniprotkb": "Solute carrier family 12 member 7; Electroneutral potassium-chloride cotransporter 4; K-Cl cotransporter 4", "protein_names_refseq": "K-Cl cotransporter 4; K-Cl cotransporter KCC4; electroneutral potassium-chloride cotransporter 4; furosemide-sensitive KCl cotransporter 4; solute carrier family 12 (potassium/chloride transporter), member 7; solute carrier family 12 (potassium/chloride transporters), member 7; solute carrier family 12 member 7", "tax_id": 10116, "disease": "epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:308069); (R-RNO-426117)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15533301;16872584;18984587;19923415;24089410;29393594", "class_list": "", "function": "Data are consistent with a role for KCC4 in salt reabsorption of the thick ascending loop of Henle's loop and acid secretion of the collecting duct., [RefSeq, PubMed]; Distribution of KCC1, KCC3a, KCC3b, KCC4, and KCC2 protein and mrna in pancreatic alpha-cells and beta-cells; KCC's make a significant contribution to volume homeostasis only in alpha-cells, [RefSeq, PubMed]; In the rat brain, KCC4 express in the choroid plexus and the suprachiasmatic nucleus of the hypothalamus., [RefSeq, PubMed]; KCC4 and H+,K+-ATPase are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state., [RefSeq, PubMed]; Kinetic models of Na+-K+-2Cl- costransporter (NKCC2) and K+-Cl- cotransporter (KCC4), two of the key cotransporters of the Henle limb, are fashioned with inclusion of terms representing binding and transport of NH4+., [RefSeq, PubMed]; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (By similarity). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q6T7Y5;Q6TUA1;Q6TUA2", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0015379 potassium:chloride symporter activity;GO:0015377 chloride:monoatomic cation symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0032991 protein-containing complex;GO:0016020 membrane", "go_biological_process": "GO:0071333 cellular response to glucose stimulus;GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q5RK27-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5J3K5-1", "uniprot_id": [ { "id": "VR102_RAT", "url": "https://www.uniprot.org/uniprot/Q5J3K5", "type": "external" } ], "mass": 38467.0, "length": 336, "protein_name": "Vomeronasal type-1 receptor 102", "gene_name": "Vom1r102; Vom1r104", "organism": "Rat", "refseq_name": "vomeronasal type-1 receptor 102 isoform 2", "refseq_ac": [ { "id": "NP_001395764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001395764", "type": "external" } ], "gene_names_uniprotkb": "Vom1r102; Vom1r104; V1ra15; Vnr2; Vom1r105", "gene_names_refseq": "V1ra15; Vn2; Vnr2; Vom1r102", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 102; Pheromone receptor VN2; Vomeronasal receptor 2; Vomeronasal type-1 receptor A15", "protein_names_refseq": "pheromone receptor VN2; putative pheromone receptor VN2; vomernasal 1 receptor Vom1r102; vomeronasal V1r-type receptor V1ra15; vomeronasal receptor 2; vomeronasal type-1 receptor 102 isoform 2; vomeronasal type-1 receptor 102; vomeronasal type-1 receptor A15", "tax_id": 10116, "disease": "", "pathway": " (rno:286957)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7585937", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62856", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5J3K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PQP1-1", "uniprot_id": [ { "id": "RBMS1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PQP1", "type": "external" } ], "mass": 44068.0, "length": 403, "protein_name": "RNA-binding motif, single-stranded-interacting protein 1", "gene_name": "Rbms1", "organism": "Rat", "refseq_name": "RNA-binding motif, single-stranded-interacting protein 1", "refseq_ac": [ { "id": "NP_001012184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012184", "type": "external" } ], "gene_names_uniprotkb": "Rbms1", "gene_names_refseq": "Rbms1", "protein_names_uniprotkb": "RNA-binding motif, single-stranded-interacting protein 1", "protein_names_refseq": "RNA-binding motif, single-stranded-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:362138)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PQP1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P7B0-1", "uniprot_id": [ { "id": "SYWC_RAT", "url": "https://www.uniprot.org/uniprot/Q6P7B0", "type": "external" } ], "mass": 54144.0, "length": 481, "protein_name": "Tryptophan--tRNA ligase, cytoplasmic", "gene_name": "Wars1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wars1; Wars", "gene_names_refseq": "", "protein_names_uniprotkb": "Tryptophan--tRNA ligase, cytoplasmic; 6.1.1.2; TrpRS; Tryptophanyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 10116, "disease": "autosomal dominant distal hereditary motor neuronopathy 9 (Disease Ontology:DOID:0111212)", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "34502162;8889548", "class_list": "", "function": "Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). Could also possess an angiostatic activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0035556 intracellular signal transduction;GO:0045765 regulation of angiogenesis;GO:0006436 tryptophanyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6P7B0-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Z2-1", "uniprot_id": [ { "id": "PTN9_RAT", "url": "https://www.uniprot.org/uniprot/Q641Z2", "type": "external" } ], "mass": 67962.0, "length": 593, "protein_name": "Tyrosine-protein phosphatase non-receptor type 9", "gene_name": "Ptpn9", "organism": "Rat", "refseq_name": "tyrosine-protein phosphatase non-receptor type 9", "refseq_ac": [ { "id": "NP_001013058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013058", "type": "external" } ], "gene_names_uniprotkb": "Ptpn9", "gene_names_refseq": "Meg2; Ptpn9", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 9; 3.1.3.48", "protein_names_refseq": "tyrosine-protein phosphatase non-receptor type 9", "tax_id": 10116, "disease": "", "pathway": " (rno:266611)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "27655914", "class_list": "", "function": "As a result, overexpression of PTP-MEG2 down-regulates NGF/TrkA signaling and blocks neurite outgrowth and differentiation, [RefSeq, PubMed]; Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K3Y9", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0044306 neuron projection terminus", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0007165 signal transduction;GO:0010977 negative regulation of neuron projection development;GO:1903078 positive regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q641Z2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FR5-1", "uniprot_id": [ { "id": "TM209_RAT", "url": "https://www.uniprot.org/uniprot/Q68FR5", "type": "external" } ], "mass": 62914.0, "length": 561, "protein_name": "Transmembrane protein 209", "gene_name": "Tmem209", "organism": "Rat", "refseq_name": "transmembrane protein 209 isoform 1", "refseq_ac": [ { "id": "NP_001014077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014077", "type": "external" } ], "gene_names_uniprotkb": "Tmem209", "gene_names_refseq": "RGD1309682; Tmem209", "protein_names_uniprotkb": "Transmembrane protein 209", "protein_names_refseq": "transmembrane protein 209 isoform 1", "tax_id": 10116, "disease": "", "pathway": " (rno:312200)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Nuclear envelope protein which in association with NUP205, may be involved in nuclear transport of various nuclear proteins in addition to MYC., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FR5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P726-1", "uniprot_id": [ { "id": "TMM19_RAT", "url": "https://www.uniprot.org/uniprot/Q6P726", "type": "external" } ], "mass": 37750.0, "length": 351, "protein_name": "Transmembrane protein 19", "gene_name": "Tmem19", "organism": "Rat", "refseq_name": "transmembrane protein 19", "refseq_ac": [ { "id": "NP_954529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954529", "type": "external" } ], "gene_names_uniprotkb": "Tmem19", "gene_names_refseq": "Tmem19", "protein_names_uniprotkb": "Transmembrane protein 19", "protein_names_refseq": "transmembrane protein 19", "tax_id": 10116, "disease": "", "pathway": " (rno:299800)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P726-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZE8-1", "uniprot_id": [ { "id": "TM59L_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZE8", "type": "external" } ], "mass": 36976.0, "length": 331, "protein_name": "Transmembrane protein 59-like", "gene_name": "Tmem59l", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tmem59l; Bsmap", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protein 59-like; Brain-specific membrane-anchored protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:306349)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0001658 branching involved in ureteric bud morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5HZE8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q719N3-1", "uniprot_id": [ { "id": "PAQRB_RAT", "url": "https://www.uniprot.org/uniprot/Q719N3", "type": "external" } ], "mass": 27648.0, "length": 238, "protein_name": "Monocyte to macrophage differentiation factor", "gene_name": "Mmd", "organism": "Rat", "refseq_name": "monocyte to macrophage differentiation factor", "refseq_ac": [ { "id": "NP_001007674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007674", "type": "external" } ], "gene_names_uniprotkb": "Mmd; Maf; Paqr11", "gene_names_refseq": "Maf; Mmd", "protein_names_uniprotkb": "Monocyte to macrophage differentiation factor; MAF; Macrophage/microglia activation-associated factor; Progestin and adipoQ receptor family member 11; Progestin and adipoQ receptor family member XI", "protein_names_refseq": "macrophage/microglia activation-associated factor; monocyte to macrophage differentiation factor; monocyte to macrophage differentiation protein; progestin and adipoQ receptor family member 11; progestin and adipoQ receptor family member XI", "tax_id": 10116, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:303439)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15063720", "class_list": "", "function": "Is involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0140911 pore-forming activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0045666 positive regulation of neuron differentiation;GO:0045860 positive regulation of protein kinase activity;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q719N3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6V7K3-1", "uniprot_id": [ { "id": "S35B1_RAT", "url": "https://www.uniprot.org/uniprot/Q6V7K3", "type": "external" } ], "mass": 35817.0, "length": 322, "protein_name": "Solute carrier family 35 member B1", "gene_name": "Slc35b1", "organism": "Rat", "refseq_name": "solute carrier family 35 member B1", "refseq_ac": [ { "id": "NP_954512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954512", "type": "external" } ], "gene_names_uniprotkb": "Slc35b1", "gene_names_refseq": "AXER; Slc35b1; UGTrel1", "protein_names_uniprotkb": "Solute carrier family 35 member B1; ATP/ADP exchanger ER; AXER; Endoplasmic reticulum ATP/ADP translocase; UDP-galactose transporter-related protein 1; UGTrel1", "protein_names_refseq": "ATP/ADP exchanger ER; UDP-galactose transporter-related protein 1; endoplasmic reticulum ATP/ADP translocase; solute carrier family 35 member B1", "tax_id": 10116, "disease": "", "pathway": " (rno:287642)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9010752", "class_list": "", "function": "ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane (By similarity). Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (By similarity). Regulates ER energy metabolism and protein biogenesis (By similarity). Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply (By similarity). Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER (By similarity). Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P70639", "ec_number_list": [], "go_molecular_function": "GO:0005471 ATP:ADP antiporter activity;GO:0005459 UDP-galactose transmembrane transporter activity;GO:0005460 UDP-glucose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072334 UDP-galactose transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6V7K3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Y6-1", "uniprot_id": [ { "id": "PPM1J_RAT", "url": "https://www.uniprot.org/uniprot/Q641Y6", "type": "external" } ], "mass": 55211.0, "length": 504, "protein_name": "Protein phosphatase 1J", "gene_name": "Ppm1j", "organism": "Rat", "refseq_name": "protein phosphatase 1J", "refseq_ac": [ { "id": "NP_001005540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005540", "type": "external" } ], "gene_names_uniprotkb": "Ppm1j; Ppp2cz", "gene_names_refseq": "Ppm1j", "protein_names_uniprotkb": "Protein phosphatase 1J; 3.1.3.16; PP2C-zeta; Protein phosphatase 2C isoform zeta", "protein_names_refseq": "PP2C-zeta; protein phosphatase 1J; protein phosphatase 2C zeta", "tax_id": 10116, "disease": "", "pathway": " (rno:295341)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q641Y6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ44-1", "uniprot_id": [ { "id": "S13A5_RAT", "url": "https://www.uniprot.org/uniprot/Q8CJ44", "type": "external" } ], "mass": 63878.0, "length": 572, "protein_name": "Na(+)/citrate cotransporter", "gene_name": "Slc13a5", "organism": "Rat", "refseq_name": "Na(+)/citrate cotransporter", "refseq_ac": [ { "id": "NP_733768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733768", "type": "external" } ], "gene_names_uniprotkb": "Slc13a5; Nact", "gene_names_refseq": "Nact; Slc13a5", "protein_names_uniprotkb": "Na(+)/citrate cotransporter; NaCT; Sodium-coupled citrate transporter; Sodium-dependent citrate transporter; Solute carrier family 13 member 5", "protein_names_refseq": "Na(+)/citrate cotransporter; sodium-coupled citrate transporter; sodium-dependent citrate transporter; solute carrier family 13 (sodium-dependent citrate transporter), member 5", "tax_id": 10116, "disease": "alcohol-related neurodevelopmental disorder (Disease Ontology:DOID:0050667); developmental and epileptic encephalopathy 25 (Disease Ontology:DOID:0080453); Kohlschutter-Tonz syndrome (Disease Ontology:DOID:0111668); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:266998); (R-RNO-9955298)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12177002;12826022;14656221;16973915;24222346;26303333;26647160", "class_list": "", "function": "Expression and function of NaCT in a cell line and in primary hepatocytes from rat liver., [RefSeq, PubMed]; High-affinity sodium/citrate cotransporter that mediates citrate entry into cells, which is a critical participant of biochemical pathways (PubMed:12177002, PubMed:12826022, PubMed:14656221). May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis (By similarity). Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form (PubMed:12177002, PubMed:12826022, PubMed:14656221). Can recognize succinate as a substrate, but its affinity for succinate is several fold lower than for citrate (PubMed:12177002, PubMed:14656221). The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic (PubMed:12177002, PubMed:14656221). Involved in the regulation of citrate levels in the brain (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; NaCT is expressed in liver, testis and brain in rat and shows preference for citrate over dicarboxylates; it may play a role in cellular utilization of citrate in blood for the synthesis of fatty acids and cholesterol and for the generation of energy, [RefSeq, PubMed]; Suggest that mIndy is a CREB-dependent glucagon target gene that is induced in fasting and in type 2 diabetes, [RefSeq, PubMed]; These data suggest that inducible liver-selective reduction of mIndy in rats is able to ameliorate hepatic steatosis and insulin resistance, conditions occurring with high calorie diets and during aging., [RefSeq, PubMed]; This study thus identified the Slc13a5 as an AhR target gene, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0015137 citrate transmembrane transporter activity;GO:0017153 sodium:dicarboxylate symporter activity;GO:0005343 organic acid:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015746 citrate transport;GO:0071285 cellular response to lithium ion;GO:0015742 alpha-ketoglutarate transport;GO:0015729 oxaloacetate transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8CJ44-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63364-1", "uniprot_id": [ { "id": "PJA2_RAT", "url": "https://www.uniprot.org/uniprot/Q63364", "type": "external" } ], "mass": 77921.0, "length": 707, "protein_name": "E3 ubiquitin-protein ligase Praja-2", "gene_name": "Pja2", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase Praja-2 isoform 2", "refseq_ac": [ { "id": "NP_001264207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264207", "type": "external" } ], "gene_names_uniprotkb": "Pja2; Neurodap1", "gene_names_refseq": "Neurodap1; Pja2; praja2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Praja-2; 2.3.2.27; Praja2; RING-type E3 ubiquitin transferase Praja-2", "protein_names_refseq": "E3 ubiquitin-protein ligase Praja-2 isoform 2; E3 ubiquitin-protein ligase Praja-2; RING-type E3 ubiquitin transferase Praja-2; praja 2, RING-H2 motif containing; praja ring finger 2, E3 ubiquitin protein ligase; protein carrying the RING-H2 sequence motif", "tax_id": 10116, "disease": "", "pathway": " (rno:192256); (R-RNO-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21423175;29393594;7623148", "class_list": "", "function": "Data suggest that praja2 regulates the stability and total concentration of protein kinase A R subunits, tuning the strength and duration of PKA signal output in response to cAMP., [RefSeq, PubMed]; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. Plays a role in ciliogenesis by ubiquitinating OFD1 (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0046330 positive regulation of JNK cascade;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63364-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CJ42-1", "uniprot_id": [ { "id": "PR7B1_RAT", "url": "https://www.uniprot.org/uniprot/Q8CJ42", "type": "external" } ], "mass": 29010.0, "length": 251, "protein_name": "Prolactin-7B1", "gene_name": "Prl7b1", "organism": "Rat", "refseq_name": "prolactin-7B1 precursor", "refseq_ac": [ { "id": "NP_714960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714960", "type": "external" } ], "gene_names_uniprotkb": "Prl7b1; Prlpn", "gene_names_refseq": "Prl7b1; Prlpn", "protein_names_uniprotkb": "Prolactin-7B1; PLP-N; PRL-like protein N; Placental prolactin-like protein N", "protein_names_refseq": "PLP-N; PRL-like protein N; placental prolactin-like protein N; prolactin-7B1 precursor; prolactin-7B1", "tax_id": 10116, "disease": "", "pathway": " (rno:266804)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12488360;29393594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8CJ42-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYD2-1", "uniprot_id": [ { "id": "STN1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYD2", "type": "external" } ], "mass": 46783.0, "length": 408, "protein_name": "CST complex subunit STN1", "gene_name": "Stn1", "organism": "Rat", "refseq_name": "CST complex subunit STN1 isoform 3", "refseq_ac": [ { "id": "NP_001011943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011943", "type": "external" } ], "gene_names_uniprotkb": "Stn1; Obfc1", "gene_names_refseq": "Obfc1; Stn1", "protein_names_uniprotkb": "CST complex subunit STN1; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; Suppressor of cdc thirteen homolog", "protein_names_refseq": "CST complex subunit STN1 isoform 3; CST complex subunit STN1; STN1, CST complex subunit; oligonucleotide/oligosaccharide-binding fold containing 1; oligonucleotide/oligosaccharide-binding fold-containing protein 1; suppressor of cdc thirteen homolog", "tax_id": 10116, "disease": "telangiectasis (Disease Ontology:DOID:1272); melanoma (Disease Ontology:DOID:1909)", "pathway": " (rno:294025); (R-RNO-174411); (R-RNO-174430)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity)., [UniProtKB, UniProtKB]; Component of the CST complex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0003697 single-stranded DNA binding;GO:0043047 single-stranded telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000781 chromosome, telomeric region;GO:1990879 CST complex", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0000723 telomere maintenance;GO:0016233 telomere capping;GO:0032211 negative regulation of telomere maintenance via telomerase;GO:0045740 positive regulation of DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYD2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TP40-1", "uniprot_id": [ { "id": "PCNP_RAT", "url": "https://www.uniprot.org/uniprot/Q7TP40", "type": "external" } ], "mass": 20195.0, "length": 189, "protein_name": "PEST proteolytic signal-containing nuclear protein", "gene_name": "Pcnp", "organism": "Rat", "refseq_name": "PEST proteolytic signal-containing nuclear protein isoform X2", "refseq_ac": [ { "id": "XP_063126478", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063126478", "type": "external" } ], "gene_names_uniprotkb": "Pcnp; Ab2-416", "gene_names_refseq": "Ab2-416; Pcnp", "protein_names_uniprotkb": "PEST proteolytic signal-containing nuclear protein; Liver regeneration-related protein LRRG084; PCNP; PEST-containing nuclear protein", "protein_names_refseq": "PEST proteolytic signal-containing nuclear protein isoform X2", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May be involved in cell cycle regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7TP40-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY63-1", "uniprot_id": [ { "id": "NUDT5_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY63", "type": "external" } ], "mass": 24117.0, "length": 219, "protein_name": "ADP-sugar pyrophosphatase", "gene_name": "Nudt5", "organism": "Rat", "refseq_name": "ADP-sugar pyrophosphatase", "refseq_ac": [ { "id": "NP_001007734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007734", "type": "external" } ], "gene_names_uniprotkb": "Nudt5", "gene_names_refseq": "Nudt5", "protein_names_uniprotkb": "ADP-sugar pyrophosphatase; 2.7.7.96; 3.6.1.13; 3.6.1.58; 8-oxo-dGDP phosphatase; Nuclear ATP-synthesis protein NUDIX5; Nucleoside diphosphate-linked moiety X motif 5; Nudix motif 5", "protein_names_refseq": "8-oxo-dGDP phosphatase; ADP-sugar pyrophosphatase; nuclear ATP-synthesis protein NUDIX5; nucleoside diphosphate-linked moiety X motif 5; nudix (nucleoside diphosphate linked moiety X)-type motif 5; nudix motif 5; nudix-type motif 5", "tax_id": 10116, "disease": "", "pathway": " (rno:361274); (R-RNO-2393930)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. In vitro, it has decapping activity on 11-mer RNA capped with uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) by hydrolyzing the pyrophosphate bridge of the sugar cap (By similarity). Does not play a role in U8 snoRNA decapping (By similarity). Binds U8 snoRNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" }, { "id": "3.6.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.13", "type": "external" }, { "id": "3.6.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.58", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" }, { "id": "3.6.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76", "type": "external" }, { "id": "2.7.7.96", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.96", "type": "external" } ], "go_molecular_function": "GO:0044715 8-oxo-dGDP phosphatase activity;GO:0019144 ADP-sugar diphosphatase activity;GO:0000287 magnesium ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0019693 ribose phosphate metabolic process;GO:0006338 chromatin remodeling;GO:0006139 nucleobase-containing compound metabolic process;GO:1990966 ATP generation from poly-ADP-D-ribose;GO:0009191 ribonucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY63-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63610-1", "uniprot_id": [ { "id": "TPM3_RAT", "url": "https://www.uniprot.org/uniprot/Q63610", "type": "external" } ], "mass": 29007.0, "length": 248, "protein_name": "Tropomyosin alpha-3 chain", "gene_name": "Tpm3", "organism": "Rat", "refseq_name": "tropomyosin alpha-3 chain isoform Tpm3.3cy", "refseq_ac": [ { "id": "NP_001288215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288215", "type": "external" } ], "gene_names_uniprotkb": "Tpm3; Tpm-5; Tpm5", "gene_names_refseq": "TM30nm; Tpm3; Tpm5", "protein_names_uniprotkb": "Tropomyosin alpha-3 chain; Gamma-tropomyosin; Tropomyosin-3; Tropomyosin-5", "protein_names_refseq": "gamma-tropomyosin; nonmuscle tropomyosin 5; tropomyosin 3, gamma; tropomyosin alpha-3 chain isoform Tpm3.3cy; tropomyosin alpha-3 chain; tropomyosin non-muscle; tropomyosin-5", "tax_id": 10116, "disease": "congenital myopathy 4A (Disease Ontology:DOID:0080102); congenital myopathy 4B (Disease Ontology:DOID:0110926); dilated cardiomyopathy (Disease Ontology:DOID:12930); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (rno:117557)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22749829;33341060;36880246;8206382;9222299", "class_list": "", "function": "All studied gamma-tropomyosin mutants reduced Ca-induced activation but had no effect on the inhibition of actomyosin cross-bridges., [RefSeq, PubMed]; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments., [UniProtKB, UniProtKB]; Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension., [RefSeq, PubMed]; [Effects of tropomyosin 3 on pyroptosis of cardiomyocytes and fibroblast activation induced by hypoxia/reoxygenation in rats]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63599;Q63600;Q63601", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005903 brush border;GO:0030426 growth cone;GO:0002102 podosome", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63610-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXZ6-1", "uniprot_id": [ { "id": "PRS40_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXZ6", "type": "external" } ], "mass": 41448.0, "length": 369, "protein_name": "Serine protease 40", "gene_name": "Prss39; Prss40", "organism": "Rat", "refseq_name": "serine protease 40 precursor", "refseq_ac": [ { "id": "NP_001013244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013244", "type": "external" } ], "gene_names_uniprotkb": "Prss39; Prss40; Tesp2", "gene_names_refseq": "Prss39; Prss40; Tesp1; Tesp2", "protein_names_uniprotkb": "Serine protease 40; 3.4.21.-; Testicular serine protease 2", "protein_names_refseq": "serine protease 40 precursor; serine protease 40-like; serine protease 40; testicular serine protease 1; testicular serine protease 2", "tax_id": 10116, "disease": "", "pathway": " (rno:316318); (rno:363215)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play an important role in the sperm/egg interaction; released during the acrosome reaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXZ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IYF9-1", "uniprot_id": [ { "id": "SUCR1_RAT", "url": "https://www.uniprot.org/uniprot/Q6IYF9", "type": "external" } ], "mass": 36679.0, "length": 317, "protein_name": "Succinate receptor 1", "gene_name": "Sucnr1", "organism": "Rat", "refseq_name": "succinate receptor 1", "refseq_ac": [ { "id": "NP_001001518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001518", "type": "external" } ], "gene_names_uniprotkb": "Sucnr1; Gpr91", "gene_names_refseq": "Gpr91; Sucnr1", "protein_names_uniprotkb": "Succinate receptor 1; G protein-coupled receptor 91", "protein_names_refseq": "G-protein coupled receptor 91; succinate receptor 1", "tax_id": 10116, "disease": "", "pathway": " (rno:408199); (R-RNO-373076); (R-RNO-418594)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15141213;18836459;28736181;29867110;30030103;31645725;32856916;32992522", "class_list": "", "function": "A pathway of metabolite signaling where succinate, acting through GPR91, governs retinal angiogenesis and show the propensity of RGCs to act as sensors of ischemic stress., [RefSeq, PubMed]; G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (PubMed:15141213). Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasisn (By similarity). In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (By similarity). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involved in immune function (By similarity). In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (By similarity). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells (By similarity). In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity. In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock-regulated manner. In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (By similarity). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons (PubMed:18836459)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; GPR91 Receptor Mediates Protection against Doxorubicin-Induced Cardiotoxicity without Altering Its Anticancer Efficacy. An In Vitro Study on H9C2 Cardiomyoblasts and Breast Cancer-Derived MCF-7 Cells. Erratum:[Cells. 2025 Oct 10;14(20):1574. doi: 10.3390/cells14201574. PMID: 41148859] Publication Status: Online-Only, [RefSeq, PubMed]; High-resolution crystal structure of rat SUCNR1 in complex with an intracellular binding nanobody in the inactive conformation, [RefSeq, PubMed]; More than an intermediate, succinate functioned as a signaling molecule to link metabolic reprograming with angiogenesis. Intracellular succinate induced angiogenesis through HIF-1alpha induction, while extracellular succinate acted on GPR91 activation, working together to disturb energy metabolism and exacerbate inflammation and angiogenesis in arthritis synovium, [RefSeq, PubMed]; Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1., [RefSeq, PubMed]; Succinate-mediated GPR91 activation might be a potential therapeutic strategy for protecting cardiomyocytes from ischemic injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0051592 response to calcium ion;GO:0060177 regulation of angiotensin metabolic process;GO:0097009 energy homeostasis;GO:0042593 glucose homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q6IYF9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VI60-1", "uniprot_id": [ { "id": "SULF1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VI60", "type": "external" } ], "mass": 100860.0, "length": 870, "protein_name": "Extracellular sulfatase Sulf-1", "gene_name": "Sulf1", "organism": "Rat", "refseq_name": "extracellular sulfatase Sulf-1 precursor", "refseq_ac": [ { "id": "NP_599205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599205", "type": "external" } ], "gene_names_uniprotkb": "Sulf1", "gene_names_refseq": "RSulfFP1; Sulf1", "protein_names_uniprotkb": "Extracellular sulfatase Sulf-1; 3.1.6.14; 3.1.6.1; Arylsulfatase; N-acetylglucosamine-6-sulfatase; RSulfFP1; Sulfatase FP", "protein_names_refseq": "N-acetylglucosamine-6-sulfatase; arylsulfatase; extracellular sulfatase Sulf-1 precursor; extracellular sulfatase Sulf-1; sulfatase FP", "tax_id": 10116, "disease": "", "pathway": " (rno:171396)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11895481;16289059;25448158;25469740;26464246;33128921", "class_list": "", "function": "Examination of epiphyseal growth plates revealed differential, inverse patterns of SULF1 and SULF2 expressions, with the former enriched in quiescent and the latter in hypertrophic chondrocyte zones., [RefSeq, PubMed]; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (By similarity). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (By similarity). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (By similarity)., [UniProtKB, UniProtKB]; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin., [UniProtKB, UniProtKB]; Findings show an upregulation of SULF1 in degenerative discs for the first time, and suggest that there is a link between SULF1 and disc degeneration, [RefSeq, PubMed]; It is proposed that Sulf1, Sulf2 and ErbB1 are involved in the inhibition of neurite outgrowth and may regulate structural plasticity and regeneration in the nervous system., [RefSeq, PubMed]; Sulf1 mRNA expression was increased in cultured vascular smooth muscle cells compared to rat aorta., [RefSeq, PubMed]; Sulfatase 1 mediates IL-10-induced dimethylarginine dimethylaminohydrolase-1 expression and antiproliferative effects in vascular smooth muscle cells of spontaneously hypertensive rats., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.6.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.-", "type": "external" }, { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" } ], "go_molecular_function": "GO:0008449 N-acetylglucosamine-6-sulfatase activity;GO:0005509 calcium ion binding;GO:0004065 arylsulfatase activity;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft", "go_biological_process": "GO:0030201 heparan sulfate proteoglycan metabolic process;GO:0060384 innervation;GO:0040036 regulation of fibroblast growth factor receptor signaling pathway;GO:0014846 esophagus smooth muscle contraction;GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8VI60-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63415-1", "uniprot_id": [ { "id": "PCSK6_RAT", "url": "https://www.uniprot.org/uniprot/Q63415", "type": "external" } ], "mass": 104053.0, "length": 937, "protein_name": "Proprotein convertase subtilisin/kexin type 6", "gene_name": "Pcsk6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pcsk6; Pace4", "gene_names_refseq": "", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 6; 3.4.21.-; Paired basic amino acid cleaving enzyme 4; SPC4; Subtilisin-like proprotein convertase 4; Subtilisin/kexin-like protease PACE4", "protein_names_refseq": "", "tax_id": 10116, "disease": "abdominal aortic aneurysm (Disease Ontology:DOID:7693)", "pathway": " (rno:25507); (R-RNO-167060); (R-RNO-8963889); (R-RNO-9768727)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "26479776;8070361", "class_list": "", "function": "Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" } ], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007354 zygotic determination of anterior/posterior axis, embryo;GO:0032902 nerve growth factor production;GO:0016485 protein processing;GO:0016486 peptide hormone processing;GO:0032940 secretion by cell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63415-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6B4M5-1", "uniprot_id": [ { "id": "PAR6A_RAT", "url": "https://www.uniprot.org/uniprot/Q6B4M5", "type": "external" } ], "mass": 37398.0, "length": 346, "protein_name": "Partitioning defective 6 homolog alpha", "gene_name": "Pard6a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pard6a; Par-6a; Par6a", "gene_names_refseq": "", "protein_names_uniprotkb": "Partitioning defective 6 homolog alpha; PAR-6 alpha; PAR-6A; PAR-6", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-2173791); (R-RNO-420029); (R-RNO-4608870); (R-RNO-9013149); (R-RNO-9013420); (R-RNO-9013424)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4U4X0;Q6B4M6", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0031267 small GTPase binding;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0051301 cell division;GO:0001933 negative regulation of protein phosphorylation;GO:0050714 positive regulation of protein secretion;GO:1904781 positive regulation of protein localization to centrosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6B4M5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6W3E9-1", "uniprot_id": [ { "id": "P4HA3_RAT", "url": "https://www.uniprot.org/uniprot/Q6W3E9", "type": "external" } ], "mass": 61165.0, "length": 544, "protein_name": "Prolyl 4-hydroxylase subunit alpha-3", "gene_name": "P4ha3", "organism": "Rat", "refseq_name": "prolyl 4-hydroxylase subunit alpha-3 precursor", "refseq_ac": [ { "id": "NP_942070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942070", "type": "external" } ], "gene_names_uniprotkb": "P4ha3", "gene_names_refseq": "P4ha3", "protein_names_uniprotkb": "Prolyl 4-hydroxylase subunit alpha-3; 1.14.11.2; 4-PH alpha-3; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3", "protein_names_refseq": "4-PH alpha-3; collagen prolyl 4-hydroxylase alpha III subunit; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3; prolyl 4-hydroxylase subunit alpha-3 precursor; prolyl 4-hydroxylase, alpha polypeptide III", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:361612)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14500733", "class_list": "", "function": "Analysis of collagen prolyl 4-hydroxylase isoenzyme 3, its expression and catalytic properties, [RefSeq, PubMed]; Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.2", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0004656 procollagen-proline 4-dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0016222 procollagen-proline 4-dioxygenase complex", "go_biological_process": "GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6W3E9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FS6-1", "uniprot_id": [ { "id": "PYRD1_RAT", "url": "https://www.uniprot.org/uniprot/Q68FS6", "type": "external" } ], "mass": 55490.0, "length": 498, "protein_name": "tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1", "gene_name": "Pyroxd1", "organism": "Rat", "refseq_name": "tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1", "refseq_ac": [ { "id": "NP_001004234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004234", "type": "external" } ], "gene_names_uniprotkb": "Pyroxd1", "gene_names_refseq": "Pyroxd1", "protein_names_uniprotkb": "tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1; 1.6.99.1; Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1", "protein_names_refseq": "pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1", "tax_id": 10116, "disease": "myofibrillar myopathy 8 (Disease Ontology:DOID:0080308)", "pathway": " (rno:297708)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Flavoprotein whose role is to protect RTCB, the catalytic subunit of the tRNA ligase complex (tRNA-LC) involved in tRNA splicing and unfolded protein response, from oxidative inactivation. It directly binds and shields the catalytic center of RTCB, prior to guanylylation, when it is inactive and its active site is vulnerable to oxidation under aerobic conditions. The interaction of PYROXD1 with RTCB is allosterically regulated by NAD(P)H binding and reduction of its FAD cofactor, while reoxidation of PYROXD1 thanks to its NADPH dehydrogenase activity triggers the timed release of RTCB, enabling its subsequent activation. Thereby, this protective mechanism may also function as a molecular timer, regulating RTCB activation through controlled release., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.6.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.-", "type": "external" } ], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0140299 molecular sensor activity;GO:0003959 NADPH dehydrogenase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030017 sarcomere", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0000968 tRNA exon ligation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FS6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIS1-1", "uniprot_id": [ { "id": "SSH3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIS1", "type": "external" } ], "mass": 72071.0, "length": 652, "protein_name": "Protein phosphatase Slingshot homolog 3", "gene_name": "Ssh3", "organism": "Rat", "refseq_name": "protein phosphatase Slingshot homolog 3 isoform 1", "refseq_ac": [ { "id": "NP_001012217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012217", "type": "external" } ], "gene_names_uniprotkb": "Ssh3", "gene_names_refseq": "Ssh3", "protein_names_uniprotkb": "Protein phosphatase Slingshot homolog 3; 3.1.3.16; 3.1.3.48; SSH-3L; SSH-like protein 3", "protein_names_refseq": "SSH-3L; SSH-like protein 3; protein phosphatase Slingshot homolog 3 isoform 1; protein phosphatase Slingshot homolog 3; slingshot homolog 3", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:365396)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0030837 negative regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIS1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6WWW3-1", "uniprot_id": [ { "id": "S38A6_RAT", "url": "https://www.uniprot.org/uniprot/Q6WWW3", "type": "external" } ], "mass": 50192.0, "length": 457, "protein_name": "Solute carrier family 38 member 6", "gene_name": "Slc38a6", "organism": "Rat", "refseq_name": "solute carrier family 38 member 6", "refseq_ac": [ { "id": "NP_001013117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013117", "type": "external" } ], "gene_names_uniprotkb": "Slc38a6; Nat1; Snat6", "gene_names_refseq": "Slc38a6; Snat6", "protein_names_uniprotkb": "Solute carrier family 38 member 6; Amino acid transporter SLC38A6; N-system amino acid transporter 1; NAT-1", "protein_names_refseq": "N-system amino acid transporter 1; NAT-1; Na(+)-coupled neutral amino acid transporter 6; Na+-dependent neutral amino acid transporter; amino acid transporter SLC38A6; probable sodium-coupled neutral amino acid transporter 6; solute carrier family 38 member 6", "tax_id": 10116, "disease": "", "pathway": " (rno:299139)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Amino acid transporter with an apparent selectivity for L-glutamine and L-glutamate. May facilitate glutamine uptake in excitatory neurons. The transport mechanism remains to be elucidated., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008324 monoatomic cation transmembrane transporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0015291 secondary active transmembrane transporter activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0006868 glutamine transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6WWW3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ES2-1", "uniprot_id": [ { "id": "TR135_RAT", "url": "https://www.uniprot.org/uniprot/Q67ES2", "type": "external" } ], "mass": 36491.0, "length": 321, "protein_name": "Taste receptor type 2 member 135", "gene_name": "Tas2r135", "organism": "Rat", "refseq_name": "taste receptor type 2 member 135", "refseq_ac": [ { "id": "NP_001020233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020233", "type": "external" } ], "gene_names_uniprotkb": "Tas2r135; Tas2r28", "gene_names_refseq": "RGD1561078; Tas2r135", "protein_names_uniprotkb": "Taste receptor type 2 member 135; T2R135; T2R28; T2R35; Taste receptor type 2 member 28", "protein_names_refseq": "T2R135; T2R28; T2R35; taste receptor type 2 member 135; taste receptor type 2 member 28", "tax_id": 10116, "disease": "", "pathway": " (rno:502757); (R-RNO-418594); (R-RNO-420499)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0050912 detection of chemical stimulus involved in sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ES2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TNN9-1", "uniprot_id": [ { "id": "RHCG_RAT", "url": "https://www.uniprot.org/uniprot/Q7TNN9", "type": "external" } ], "mass": 54731.0, "length": 497, "protein_name": "Ammonium transporter Rh type C", "gene_name": "Rhcg", "organism": "Rat", "refseq_name": "ammonium transporter Rh type C", "refseq_ac": [ { "id": "NP_898876", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898876", "type": "external" } ], "gene_names_uniprotkb": "Rhcg", "gene_names_refseq": "Rhcg", "protein_names_uniprotkb": "Ammonium transporter Rh type C; Rh family type C glycoprotein; Rh type C glycoprotein; Rhesus blood group family type C glycoprotein", "protein_names_refseq": "Rh type C glycoprotein; Rhesus blood group-associated C glycoprotein; ammonium transporter Rh type C; rh family type C glycoprotein; rhesus blood group family type C glycoprotein", "tax_id": 10116, "disease": "metabolic acidosis (Disease Ontology:DOID:0050758); kidney failure (Disease Ontology:DOID:1074); renal tubular acidosis (Disease Ontology:DOID:14219); hypokalemia (Disease Ontology:DOID:4500)", "pathway": " (rno:293048); (R-RNO-444411)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12138130;12595489;16227429;16434569;20392801;21753075", "class_list": "", "function": "Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (By similarity). May act as a CO2 channel providing for renal acid secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Expression of Rhbg and Rhcg parallels intercalated cell development and that immature Rhbg and Rhcg expression at birth contributes to incomplete ammonia excretion capacity., [RefSeq, PubMed]; Increased plasma membrane Rhcg expression in response to hypokalemia in the rat, particularly in the outer medullary collecting duct, likely contributes to the increased ammonia excretion and thereby to the development of metabolic alkalosis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008519 ammonium channel activity;GO:0035379 carbon dioxide transmembrane transporter activity;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0070634 transepithelial ammonium transport;GO:0006873 intracellular monoatomic ion homeostasis;GO:0072488 ammonium transmembrane transport;GO:0006885 regulation of pH", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7TNN9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIU5-1", "uniprot_id": [ { "id": "PSMF1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIU5", "type": "external" } ], "mass": 29855.0, "length": 271, "protein_name": "Proteasome inhibitor PI31 subunit", "gene_name": "Psmf1", "organism": "Rat", "refseq_name": "proteasome inhibitor PI31 subunit", "refseq_ac": [ { "id": "NP_001094475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094475", "type": "external" } ], "gene_names_uniprotkb": "Psmf1", "gene_names_refseq": "Psmf1", "protein_names_uniprotkb": "Proteasome inhibitor PI31 subunit", "protein_names_refseq": "proteasome (prosome, macropain) inhibitor subunit 1; proteasome inhibitor PI31 subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:689852)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0004866 endopeptidase inhibitor activity;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:1901799 negative regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6R6I6-1", "uniprot_id": [ { "id": "RXFP1_RAT", "url": "https://www.uniprot.org/uniprot/Q6R6I6", "type": "external" } ], "mass": 87183.0, "length": 758, "protein_name": "Relaxin receptor 1", "gene_name": "Rxfp1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rxfp1; Lgr7", "gene_names_refseq": "", "protein_names_uniprotkb": "Relaxin receptor 1; Leucine-rich repeat-containing G protein-coupled receptor 7; Relaxin family peptide receptor 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:295144); (R-RNO-444821)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15566402", "class_list": "", "function": "Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0046872 metal ion binding;GO:0042562 hormone binding;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0009755 hormone-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6R6I6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64612-1", "uniprot_id": [ { "id": "PTPRV_RAT", "url": "https://www.uniprot.org/uniprot/Q64612", "type": "external" } ], "mass": 187293.0, "length": 1711, "protein_name": "Receptor-type tyrosine-protein phosphatase V", "gene_name": "Ptprv", "organism": "Rat", "refseq_name": "receptor-type tyrosine-protein phosphatase V precursor", "refseq_ac": [ { "id": "NP_149090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_149090", "type": "external" } ], "gene_names_uniprotkb": "Ptprv; Esp", "gene_names_refseq": "Esp; Ptprv", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase V; 3.1.3.48; ES cell phosphatase; Embryonic stem cell protein-tyrosine phosphatase; OST-PTP; Osteotesticular protein-tyrosine phosphatase; R-PTP-V", "protein_names_refseq": "ES cell phosphatase; OST-PTP; Osteotesticular phosphatase; R-PTP-V; embryonic stem cell protein-tyrosine phosphatase; osteotesticular protein-tyrosine phosphatase; protein tyrosine phosphatase receptor type W; receptor-type tyrosine-protein phosphatase V precursor; receptor-type tyrosine-protein phosphatase V", "tax_id": 10116, "disease": "", "pathway": " (rno:64576)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7527035", "class_list": "", "function": "Protein tyrosine phosphatase that acts as a regulator of energy metabolism (By similarity). Prevents decarboxylation of osteocalcin (Bglap) via an indirect mechanism, preventing the hormone activity of osteocalcin (By similarity). Functions in signaling pathways during bone remodeling, as well as serve a broader role in cell interactions associated with differentiation in bone and testis (PubMed:7527035). Associated with differentiation in bone and testis (PubMed:7527035)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 17, "predicted_n_glycosites": 17, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0035335 peptidyl-tyrosine dephosphorylation;GO:0007165 signal transduction;GO:0007283 spermatogenesis;GO:0071320 cellular response to cAMP;GO:0046849 bone remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q64612-1", "record_type": "protein", "filter_code": "0000000.1000101.010000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1W5-1", "uniprot_id": [ { "id": "U1SBP_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1W5", "type": "external" } ], "mass": 29204.0, "length": 244, "protein_name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "gene_name": "Snrnp35", "organism": "Rat", "refseq_name": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein", "refseq_ac": [ { "id": "NP_001014149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014149", "type": "external" } ], "gene_names_uniprotkb": "Snrnp35; U1snrnpbp", "gene_names_refseq": "RGD1310724; Snrnp35; U1snrnpbp", "protein_names_uniprotkb": "U11/U12 small nuclear ribonucleoprotein 35 kDa protein; U1 snRNP-binding protein homolog; U11/U12 snRNP 35 kDa protein", "protein_names_refseq": "U1 snRNP-binding protein homolog; U11/U12 small nuclear ribonucleoprotein 35 kDa protein; U11/U12 snRNP 35 kDa protein; U11/U12 snRNP 35K; small nuclear ribonucleoprotein 35 (U11/U12)", "tax_id": 10116, "disease": "", "pathway": " (rno:360803); (R-RNO-72165)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0017069 snRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005681 spliceosomal complex;GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U1W5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BLX8-1", "uniprot_id": [ { "id": "WDR83_RAT", "url": "https://www.uniprot.org/uniprot/Q5BLX8", "type": "external" } ], "mass": 34382.0, "length": 315, "protein_name": "WD repeat domain-containing protein 83", "gene_name": "Wdr83", "organism": "Rat", "refseq_name": "WD repeat domain-containing protein 83", "refseq_ac": [ { "id": "NP_001041312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041312", "type": "external" } ], "gene_names_uniprotkb": "Wdr83; Morg1", "gene_names_refseq": "Morg1; RGD1306947; Wdr83", "protein_names_uniprotkb": "WD repeat domain-containing protein 83; MAPK organizer 1; Mitogen-activated protein kinase organizer 1", "protein_names_refseq": "MAPK organizer 1; WD repeat domain-containing protein 83; WD repeat protein Morg1; mitogen-activated protein kinase organizer 1", "tax_id": 10116, "disease": "", "pathway": " (rno:288924); (R-RNO-5674135)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16407229", "class_list": "", "function": "Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing. Participates in tight junction development by regulating apico-basal polarity, a key step in tissue development and organization. Mechanistically, regulates the translocation of PAR6-aPKC from the cytoplasm to the apical surface by acting as an adapter between PARD6B AND CRB3. Also acts as a negative regulator of mTORC1 under nutrient-rich conditions by binding to the active Rag GTPases to inhibit mTORC1 localization to the lysosome and phosphorylation of downstream targets. This facilitates constitutive basal autophagy during nutrient availability (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0005764 lysosome;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000375 RNA splicing, via transesterification reactions;GO:0032496 response to lipopolysaccharide;GO:0001666 response to hypoxia;GO:0009611 response to wounding;GO:0001843 neural tube closure", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BLX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64093-1", "uniprot_id": [ { "id": "S6A20_RAT", "url": "https://www.uniprot.org/uniprot/Q64093", "type": "external" } ], "mass": 68971.0, "length": 616, "protein_name": "Sodium- and chloride-dependent transporter XTRP3", "gene_name": "Slc6a20a; Slc6a20", "organism": "Rat", "refseq_name": "sodium- and chloride-dependent transporter XTRP3", "refseq_ac": [ { "id": "NP_579830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579830", "type": "external" } ], "gene_names_uniprotkb": "Slc6a20a; Slc6a20; Sit1; Slc6a20; Xtrp3", "gene_names_refseq": "Slc6a20a; Slc6a20; Xtrp3; rB21a", "protein_names_uniprotkb": "Sodium- and chloride-dependent transporter XTRP3; Sodium/imino-acid transporter 1; Solute carrier family 6 member 20; Transporter rB21A", "protein_names_refseq": "X transporter protein 3; sodium- and chloride-dependent transporter XTRP3; sodium/imino-acid transporter 1; solute carrier family 6 (neurotransmitter transporter), member 20; solute carrier family 6 (proline IMINO transporter), member 20; solute carrier family 6 member 20; transporter rB21A", "tax_id": 10116, "disease": "", "pathway": " (rno:113918); (R-RNO-352230); (R-RNO-442660)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15632147;8001687", "class_list": "", "function": "Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids (PubMed:15632147). Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015193 L-proline transmembrane transporter activity;GO:0015199 amino-acid betaine transmembrane transporter activity;GO:0005298 proline:sodium symporter activity;GO:0015370 solute:sodium symporter activity;GO:0015171 amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0016020 membrane", "go_biological_process": "GO:0015816 glycine transport;GO:1905647 proline import across plasma membrane;GO:0015824 proline transport;GO:1904271 L-proline import across plasma membrane;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q64093-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PCT5-1", "uniprot_id": [ { "id": "PQBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q6PCT5", "type": "external" } ], "mass": 30529.0, "length": 263, "protein_name": "Polyglutamine-binding protein 1", "gene_name": "Pqbp1", "organism": "Rat", "refseq_name": "polyglutamine-binding protein 1", "refseq_ac": [ { "id": "NP_001013979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013979", "type": "external" } ], "gene_names_uniprotkb": "Pqbp1", "gene_names_refseq": "Pqbp1", "protein_names_uniprotkb": "Polyglutamine-binding protein 1; PQBP-1; Polyglutamine tract-binding protein 1", "protein_names_refseq": "PQBP-1; polyglutamine tract-binding protein 1; polyglutamine-binding protein 1", "tax_id": 10116, "disease": "Renpenning syndrome (Disease Ontology:DOID:0060179)", "pathway": " (rno:302557); (R-RNO-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0003690 double-stranded DNA binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0006351 DNA-templated transcription;GO:0031175 neuron projection development;GO:0045087 innate immune response;GO:0048814 regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6PCT5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R478-1", "uniprot_id": [ { "id": "WBP2_RAT", "url": "https://www.uniprot.org/uniprot/Q8R478", "type": "external" } ], "mass": 28131.0, "length": 262, "protein_name": "WW domain-binding protein 2", "gene_name": "Wbp2", "organism": "Rat", "refseq_name": "WW domain-binding protein 2", "refseq_ac": [ { "id": "NP_620431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620431", "type": "external" } ], "gene_names_uniprotkb": "Wbp2", "gene_names_refseq": "Wbp2", "protein_names_uniprotkb": "WW domain-binding protein 2; WBP-2", "protein_names_refseq": "WBP-2; WW domain-binding protein 2", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 107 (Disease Ontology:DOID:0080262)", "pathway": " (rno:192645)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Synergizes with YAP1 to enhance PGR activity (By similarity). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0032570 response to progesterone;GO:0045893 positive regulation of DNA-templated transcription;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0043627 response to estrogen", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8R478-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63189-1", "uniprot_id": [ { "id": "PRG2_RAT", "url": "https://www.uniprot.org/uniprot/Q63189", "type": "external" } ], "mass": 25129.0, "length": 227, "protein_name": "Bone marrow proteoglycan", "gene_name": "Prg2", "organism": "Rat", "refseq_name": "bone marrow proteoglycan precursor", "refseq_ac": [ { "id": "NP_113807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113807", "type": "external" } ], "gene_names_uniprotkb": "Prg2; Mbp", "gene_names_refseq": "Prg2", "protein_names_uniprotkb": "Bone marrow proteoglycan; BMPG; Proteoglycan 2", "protein_names_refseq": "BMPG; bone marrow proteoglycan precursor; bone marrow proteoglycan; eosinophil major basic protein; proteoglycan 2, bone marrow", "tax_id": 10116, "disease": "Chagas disease (Disease Ontology:DOID:12140); peritoneum cancer (Disease Ontology:DOID:1725); asthma (Disease Ontology:DOID:2841)", "pathway": " (rno:58826); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8547309", "class_list": "", "function": "Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0032693 negative regulation of interleukin-10 production;GO:0006955 immune response;GO:0042742 defense response to bacterium;GO:0002215 defense response to nematode;GO:0032753 positive regulation of interleukin-4 production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63189-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63532-1", "uniprot_id": [ { "id": "SPR1A_RAT", "url": "https://www.uniprot.org/uniprot/Q63532", "type": "external" } ], "mass": 16734.0, "length": 152, "protein_name": "Cornifin-A", "gene_name": "Sprr1a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sprr1a; Sprr1; Spr", "gene_names_refseq": "", "protein_names_uniprotkb": "Cornifin-A; SPR1A; SPRR1; Small proline-rich protein 1A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:499660)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8624253", "class_list": "", "function": "Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0071944 cell periphery;GO:0001533 cornified envelope", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking;GO:0070268 cornification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63532-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKG6-1", "uniprot_id": [ { "id": "TRI35_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKG6", "type": "external" } ], "mass": 57304.0, "length": 501, "protein_name": "E3 ubiquitin-protein ligase TRIM35", "gene_name": "Trim35", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM35", "refseq_ac": [ { "id": "NP_001020313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020313", "type": "external" } ], "gene_names_uniprotkb": "Trim35", "gene_names_refseq": "Trim35", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM35; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM35; tripartite motif protein 35; tripartite motif-containing protein 35", "tax_id": 10116, "disease": "", "pathway": " (rno:498538)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response. Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway. Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2. Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4VBW2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0044790 suppression of viral release by host;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0045087 innate immune response;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RKG6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64121-1", "uniprot_id": [ { "id": "PRLHR_RAT", "url": "https://www.uniprot.org/uniprot/Q64121", "type": "external" } ], "mass": 41161.0, "length": 370, "protein_name": "Prolactin-releasing peptide receptor", "gene_name": "Prlhr", "organism": "Rat", "refseq_name": "prolactin-releasing peptide receptor", "refseq_ac": [ { "id": "NP_631932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631932", "type": "external" } ], "gene_names_uniprotkb": "Prlhr; Gpr10", "gene_names_refseq": "Gpr10; Prlhr; Uhr-1", "protein_names_uniprotkb": "Prolactin-releasing peptide receptor; G protein-coupled receptor 10; PrRP receptor; PrRPR; UHR-1", "protein_names_refseq": "G-protein coupled receptor 10; prRP receptor; prRPR; prolactin-releasing peptide receptor", "tax_id": 10116, "disease": "hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:246075); (R-RNO-375276)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10498338;12619141;15752583;15854142;19540425;7733930", "class_list": "", "function": "Data report that PrRP and its receptor, GPR10, were found in the mouse substantia nigra pars compacta (SNpc), the main location of dopaminergic (DA) neurons of the nigrostriatal system., [RefSeq, PubMed]; Naturally occurring polymorphism in the UHR-1 gene that results in an ATG to ATA change at the putative translational initiation site., [RefSeq, PubMed]; Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing., [UniProtKB, UniProtKB, UniProtKB]; The mutated GPR10 receptor is responsible for the hyperphagia leading to obesity and dyslipidemia in the obese diabetic OLETF strain rat., [RefSeq, PubMed]; The receptor UHR1/GPR10 gene was expressed consistently in the medullary reticular formation and the adrenal gland but also transiently in several locations., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017046 peptide hormone binding;GO:0008188 neuropeptide receptor activity;GO:0004983 neuropeptide Y receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043005 neuron projection;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior;GO:0008343 adult feeding behavior;GO:0042445 hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q64121-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M948-1", "uniprot_id": [ { "id": "TAF1D_RAT", "url": "https://www.uniprot.org/uniprot/Q5M948", "type": "external" } ], "mass": 32616.0, "length": 285, "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit D", "gene_name": "Taf1d", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Taf1d; Josd3", "gene_names_refseq": "", "protein_names_uniprotkb": "TATA box-binding protein-associated factor RNA polymerase I subunit D; TATA box-binding protein-associated factor 1D; TBP-associated factor 1D; Transcription initiation factor SL1/TIF-IB subunit D", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:363017); (R-RNO-5250924); (R-RNO-73762); (R-RNO-73772); (R-RNO-73863)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005668 RNA polymerase transcription factor SL1 complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M948-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63347-1", "uniprot_id": [ { "id": "PRS7_RAT", "url": "https://www.uniprot.org/uniprot/Q63347", "type": "external" } ], "mass": 48575.0, "length": 433, "protein_name": "26S proteasome regulatory subunit 7", "gene_name": "Psmc2", "organism": "Rat", "refseq_name": "26S proteasome regulatory subunit 7", "refseq_ac": [ { "id": "NP_150239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_150239", "type": "external" } ], "gene_names_uniprotkb": "Psmc2; Mss1", "gene_names_refseq": "MSS1; Psmc2", "protein_names_uniprotkb": "26S proteasome regulatory subunit 7; 26S proteasome AAA-ATPase subunit RPT1; Proteasome 26S subunit ATPase 2", "protein_names_refseq": "26S protease regulatory subunit 7; 26S proteasome AAA-ATPase subunit RPT1; 26S proteasome regulatory subunit 7; proteasome (prosome, macropain) 26S subunit, ATPase 2", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:25581); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-6798695); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 57, "publication_count": 3, "publication_id_list": "19638347;8607789;9533861", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show that data provide a novel mechanism whereby CaMKII may regulate the proteasome in neurons to facilitate remodeling of synaptic connections through protein degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62690;Q6P7R9", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0017025 TBP-class protein binding;GO:0140296 general transcription initiation factor binding;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005829 cytosol;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63347-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2H5-1", "uniprot_id": [ { "id": "PHLD_RAT", "url": "https://www.uniprot.org/uniprot/Q8R2H5", "type": "external" } ], "mass": 93782.0, "length": 843, "protein_name": "Phosphatidylinositol-glycan-specific phospholipase D", "gene_name": "Gpld1", "organism": "Rat", "refseq_name": "phosphatidylinositol-glycan-specific phospholipase D precursor", "refseq_ac": [ { "id": "NP_001093982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093982", "type": "external" } ], "gene_names_uniprotkb": "Gpld1", "gene_names_refseq": "Gpld1", "protein_names_uniprotkb": "Phosphatidylinositol-glycan-specific phospholipase D; 3.1.4.50; GPI-PLD; GPI-specific phospholipase D; Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; PI-G PLD", "protein_names_refseq": "GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipase D; glycosyl-phosphatidylinositol-specific phospholipase D; glycosylphosphatidylinositol phospholipase D; phosphatidylinositol-glycan-specific phospholipase D precursor; phosphatidylinositol-glycan-specific phospholipase D", "tax_id": 10116, "disease": "", "pathway": " (rno:291132); (R-RNO-163125)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11855934;30457913", "class_list": "", "function": "GPI-PLD directly regulates intracellular diacylglycerol content in rat primary hepatocytes., [RefSeq, PubMed]; Hydrolyzes the inositol phosphate linkage of glycosylphosphatidylinositol (GPI)-anchored membrane proteins, thereby releasing them from the cell surface. Cleaves on the inositol side of the anchor, leaving the phosphate group attached to the membrane. This release of GPI-anchored proteins can modulate diverse biological processes, including the activation of signaling pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.4.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.50", "type": "external" }, { "id": "3.4.11.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.9", "type": "external" } ], "go_molecular_function": "GO:0004630 phospholipase D activity;GO:0004621 glycosylphosphatidylinositol phospholipase D activity;GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0071401 cellular response to triglyceride;GO:1900076 regulation of cellular response to insulin stimulus;GO:0006629 lipid metabolic process;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R2H5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2R5-1", "uniprot_id": [ { "id": "PPR3C_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2R5", "type": "external" } ], "mass": 36413.0, "length": 317, "protein_name": "Protein phosphatase 1 regulatory subunit 3C", "gene_name": "Ppp1r3c", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 3C", "refseq_ac": [ { "id": "NP_001012072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012072", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r3c; Ppp1r5", "gene_names_refseq": "PTG; Ppp1r3c; R5", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 3C; PP1 subunit R5; PTG; Protein phosphatase 1 regulatory subunit 5; Protein targeting to glycogen", "protein_names_refseq": "PP1 subunit R5; protein phosphatase 1 regulatory subunit 3C-like; protein phosphatase 1 regulatory subunit 3C; protein phosphatase 1 regulatory subunit 5; protein phosphatase 1, regulatory (inhibitor) subunit 3C; protein targeting to glycogen", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:309513); (R-RNO-3322077)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019899 enzyme binding;GO:0030674 protein-macromolecule adaptor activity;GO:0008157 protein phosphatase 1 binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005829 cytosol;GO:0042587 glycogen granule", "go_biological_process": "GO:0005981 regulation of glycogen catabolic process;GO:0005977 glycogen metabolic process;GO:0005978 glycogen biosynthetic process;GO:0005979 regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2R5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63651-1", "uniprot_id": [ { "id": "GRK1_RAT", "url": "https://www.uniprot.org/uniprot/Q63651", "type": "external" } ], "mass": 63769.0, "length": 564, "protein_name": "Rhodopsin kinase GRK1", "gene_name": "Grk1", "organism": "Rat", "refseq_name": "rhodopsin kinase GRK1", "refseq_ac": [ { "id": "NP_112358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112358", "type": "external" } ], "gene_names_uniprotkb": "Grk1; Rhok", "gene_names_refseq": "Grk1; Rhok", "protein_names_uniprotkb": "Rhodopsin kinase GRK1; 2.7.11.14; G protein-coupled receptor kinase 1; RK", "protein_names_refseq": "G protein-coupled receptpr kinase 1; RK; rhodopsin kinase GRK1", "tax_id": 10116, "disease": "Oguchi disease-2 (Disease Ontology:DOID:0110713); alcohol use disorder (Disease Ontology:DOID:1574); retinal disease (Disease Ontology:DOID:5679); congestive heart failure (Disease Ontology:DOID:6000); night blindness (Disease Ontology:DOID:8499)", "pathway": " (rno:81760); (R-RNO-2514859)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11717351;21504899;24914207;26350504;9147475", "class_list": "", "function": "AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling. Erratum:[Ann Biomed Eng. 2016 Mar;44(3):830-2. doi: 10.1007/s10439-015-1537-7. PMID: 26715208], [RefSeq, PubMed]; Cytoskeletal reorganization evoked by Rho-associated kinase- and protein kinase C-catalyzed phosphorylation of cofilin and heat shock protein 27, respectively, contributes to myogenic constriction of rat cerebral arteries., [RefSeq, PubMed]; Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (By similarity). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.11.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0050254 rhodopsin kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007601 visual perception;GO:0046777 protein autophosphorylation;GO:0009966 regulation of signal transduction;GO:0042327 positive regulation of phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63651-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIH3-1", "uniprot_id": [ { "id": "S28A3_RAT", "url": "https://www.uniprot.org/uniprot/Q8VIH3", "type": "external" } ], "mass": 78374.0, "length": 705, "protein_name": "Solute carrier family 28 member 3", "gene_name": "Slc28a3", "organism": "Rat", "refseq_name": "solute carrier family 28 member 3", "refseq_ac": [ { "id": "NP_543184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543184", "type": "external" } ], "gene_names_uniprotkb": "Slc28a3; Cnt3", "gene_names_refseq": "Cnt3; Slc28a3", "protein_names_uniprotkb": "Solute carrier family 28 member 3; CNT 3; Concentrative Na(+)-nucleoside cotransporter 3; rCNT3", "protein_names_refseq": "CNT 3; concentrative Na(+)-nucleoside cotransporter 3; rCNT3; solute carrier family 28 (concentrative nucleoside transporter), member 3; solute carrier family 28 (sodium-coupled nucleoside transporter), member 3; solute carrier family 28 member 3", "tax_id": 10116, "disease": "", "pathway": " (rno:140944); (R-RNO-83936); (R-RNO-9748787); (R-RNO-9755088)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "16014043;25034758", "class_list": "", "function": "Diabetes increased CNT1 and CNT3 expression in the glomerulus and insulin treatment decreased it., [RefSeq, PubMed]; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine., [UniProtKB, UniProtKB]; There is functional crosstalk between the adenosine transporter CNT3 and purinergic receptors in the cholangiocytes in rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015213 uridine transmembrane transporter activity;GO:0015389 pyrimidine- and adenosine-specific:sodium symporter activity;GO:0015390 purine-specific nucleoside:sodium symporter activity;GO:0005337 nucleoside transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0015860 purine nucleoside transmembrane transport;GO:0015862 uridine transmembrane transport;GO:0001895 retina homeostasis;GO:0015864 pyrimidine nucleoside transport;GO:1901642 nucleoside transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8VIH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71QF9-1", "uniprot_id": [ { "id": "PRIC1_RAT", "url": "https://www.uniprot.org/uniprot/Q71QF9", "type": "external" } ], "mass": 94170.0, "length": 831, "protein_name": "Prickle-like protein 1", "gene_name": "Prickle1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Prickle1; Rilp", "gene_names_refseq": "", "protein_names_uniprotkb": "Prickle-like protein 1; REST/NRSF-interacting LIM domain protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive Robinow syndrome (Disease Ontology:DOID:0060764); progressive myoclonus epilepsy 1B (Disease Ontology:DOID:0111448); velocardiofacial syndrome (Disease Ontology:DOID:12583); epilepsy (Disease Ontology:DOID:1826); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (rno:315259); (R-RNO-4608870)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "14645515", "class_list": "", "function": "Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity). Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0016020 membrane", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0061326 renal tubule development;GO:0007409 axonogenesis;GO:0007507 heart development;GO:0016358 dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q71QF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ET4-1", "uniprot_id": [ { "id": "TR125_RAT", "url": "https://www.uniprot.org/uniprot/Q67ET4", "type": "external" } ], "mass": 35639.0, "length": 310, "protein_name": "Taste receptor type 2 member 125", "gene_name": "Tas2r125", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tas2r125; T2r16", "gene_names_refseq": "", "protein_names_uniprotkb": "Taste receptor type 2 member 125; T2R16; T2r125; Taste receptor type 2 member 16", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ET4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJW3-1", "uniprot_id": [ { "id": "TX261_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJW3", "type": "external" } ], "mass": 22524.0, "length": 196, "protein_name": "Protein TEX261", "gene_name": "Tex261", "organism": "Rat", "refseq_name": "protein TEX261", "refseq_ac": [ { "id": "NP_001017537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017537", "type": "external" } ], "gene_names_uniprotkb": "Tex261", "gene_names_refseq": "Tex261", "protein_names_uniprotkb": "Protein TEX261", "protein_names_refseq": "protein TEX261; testis expressed gene 261", "tax_id": 10116, "disease": "", "pathway": " (rno:297392)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097020 COPII receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJW3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BJX0-1", "uniprot_id": [ { "id": "NTM1A_RAT", "url": "https://www.uniprot.org/uniprot/Q5BJX0", "type": "external" } ], "mass": 25464.0, "length": 223, "protein_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "gene_name": "Ntmt1", "organism": "Rat", "refseq_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "refseq_ac": [ { "id": "NP_001020190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020190", "type": "external" } ], "gene_names_uniprotkb": "Ntmt1; Mettl11a", "gene_names_refseq": "Mettl11a; NTM1A; Ntmt1; RGD1306582", "protein_names_uniprotkb": "N-terminal Xaa-Pro-Lys N-methyltransferase 1; 2.1.1.244; Alpha N-terminal protein methyltransferase 1A; Methyltransferase-like protein 11A; NTM1A; X-Pro-Lys N-terminal protein methyltransferase 1A", "protein_names_refseq": "N-terminal Xaa-Pro-Lys N-methyltransferase 1; X-Pro-Lys N-terminal protein methyltransferase 1A; alpha N-terminal protein methyltransferase 1A; methyltransferase like 11A; methyltransferase-like protein 11A", "tax_id": 10116, "disease": "", "pathway": " (rno:362103)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.244", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.244", "type": "external" } ], "go_molecular_function": "GO:0071885 N-terminal protein N-methyltransferase activity;GO:0008276 protein methyltransferase activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0018012 N-terminal peptidyl-alanine trimethylation;GO:0018013 N-terminal peptidyl-glycine methylation;GO:0018016 N-terminal peptidyl-proline dimethylation;GO:0035572 N-terminal peptidyl-serine dimethylation;GO:0035573 N-terminal peptidyl-serine trimethylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BJX0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK13-1", "uniprot_id": [ { "id": "VMA12_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK13", "type": "external" } ], "mass": 23160.0, "length": 208, "protein_name": "Vacuolar ATPase assembly protein VMA12", "gene_name": "Vma12", "organism": "Rat", "refseq_name": "vacuolar ATPase assembly protein VMA12", "refseq_ac": [ { "id": "NP_001020163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020163", "type": "external" } ], "gene_names_uniprotkb": "Vma12; Tmem199", "gene_names_refseq": "Tmem199; Vma12", "protein_names_uniprotkb": "Vacuolar ATPase assembly protein VMA12; Transmembrane protein 199", "protein_names_refseq": "transmembrane protein 199; vacuolar ATPase assembly protein VMA12", "tax_id": 10116, "disease": "congenital disorder of glycosylation type IIp (Disease Ontology:DOID:0070268)", "pathway": " (rno:303332)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly;GO:0007042 lysosomal lumen acidification;GO:0036295 cellular response to increased oxygen levels;GO:1905146 lysosomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK13-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK64-1", "uniprot_id": [ { "id": "RPP40_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK64", "type": "external" } ], "mass": 41640.0, "length": 363, "protein_name": "Ribonuclease P protein subunit p40", "gene_name": "Rpp40", "organism": "Rat", "refseq_name": "ribonuclease P protein subunit p40 isoform 1", "refseq_ac": [ { "id": "NP_001013073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013073", "type": "external" } ], "gene_names_uniprotkb": "Rpp40", "gene_names_refseq": "Rpp40", "protein_names_uniprotkb": "Ribonuclease P protein subunit p40; RNaseP protein p40", "protein_names_refseq": "RNaseP protein p40; ribonuclease P 40 subunit; ribonuclease P protein subunit p40 isoform 1; ribonuclease P protein subunit p40; ribonuclease P/MRP 40 subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:291071); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033204 ribonuclease P RNA binding;GO:0004526 ribonuclease P activity", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0000172 ribonuclease MRP complex;GO:0030677 ribonuclease P complex", "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5BK64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK75-1", "uniprot_id": [ { "id": "S46A3_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK75", "type": "external" } ], "mass": 51527.0, "length": 461, "protein_name": "Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3", "gene_name": "Slc46a3", "organism": "Rat", "refseq_name": "lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 precursor", "refseq_ac": [ { "id": "NP_001020139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020139", "type": "external" } ], "gene_names_uniprotkb": "Slc46a3", "gene_names_refseq": "RGD1307594; Slc46a3", "protein_names_uniprotkb": "Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3; Solute carrier family 46 member 3", "protein_names_refseq": "lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 precursor; lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3", "tax_id": 10116, "disease": "", "pathway": " (rno:288454)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (By similarity). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (By similarity). Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (By similarity). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity;GO:0005375 copper ion transmembrane transporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine;GO:0034486 vacuolar transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK75-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5BK81-1", "uniprot_id": [ { "id": "PTGR2_RAT", "url": "https://www.uniprot.org/uniprot/Q5BK81", "type": "external" } ], "mass": 38136.0, "length": 351, "protein_name": "Prostaglandin reductase 2", "gene_name": "Ptgr2", "organism": "Rat", "refseq_name": "prostaglandin reductase 2 isoform 2", "refseq_ac": [ { "id": "NP_001015009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015009", "type": "external" } ], "gene_names_uniprotkb": "Ptgr2; Zadh1", "gene_names_refseq": "Ptgr2; Zadh1", "protein_names_uniprotkb": "Prostaglandin reductase 2; 1.3.1.48; 15-oxoprostaglandin 13-reductase; PRG-2; Zinc-binding alcohol dehydrogenase domain-containing protein 1", "protein_names_refseq": "15-oxoprostaglandin 13-reductase; PRG-2; prostaglandin reductase 2 isoform 2; zinc binding alcohol dehydrogenase, domain containing 1; zinc-binding alcohol dehydrogenase domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:299194)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.48", "type": "external" }, { "id": "1.3.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.74", "type": "external" } ], "go_molecular_function": "GO:0047522 15-oxoprostaglandin 13-reductase [NAD(P)+] activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006693 prostaglandin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5BK81-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EB66-1", "uniprot_id": [ { "id": "TRIQK_RAT", "url": "https://www.uniprot.org/uniprot/Q5EB66", "type": "external" } ], "mass": 9677.0, "length": 86, "protein_name": "Triple QxxK/R motif-containing protein", "gene_name": "Triqk", "organism": "Rat", "refseq_name": "triple QxxK/R motif-containing protein", "refseq_ac": [ { "id": "NP_001165273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165273", "type": "external" } ], "gene_names_uniprotkb": "Triqk", "gene_names_refseq": "Triqk", "protein_names_uniprotkb": "Triple QxxK/R motif-containing protein; Triple repetitive-sequence of QXXK/R protein homolog", "protein_names_refseq": "protein TRIQK; triple QxxK/R motif-containing protein; triple repetitive-sequence of QXXK/R protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:500413)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in cell growth and maintenance of cell morphology., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5EB66-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EB92-1", "uniprot_id": [ { "id": "WDR70_RAT", "url": "https://www.uniprot.org/uniprot/Q5EB92", "type": "external" } ], "mass": 72836.0, "length": 655, "protein_name": "WD repeat-containing protein 70", "gene_name": "Wdr70", "organism": "Rat", "refseq_name": "WD repeat-containing protein 70", "refseq_ac": [ { "id": "NP_001013931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013931", "type": "external" } ], "gene_names_uniprotkb": "Wdr70", "gene_names_refseq": "RGD1309487; Wdr70", "protein_names_uniprotkb": "WD repeat-containing protein 70", "protein_names_refseq": "WD repeat-containing protein 70", "tax_id": 10116, "disease": "", "pathway": " (rno:294783); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0035861 site of double-strand break;GO:0071006 U2-type catalytic step 1 spliceosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5EB92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVF4-1", "uniprot_id": [ { "id": "TM7S3_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVF4", "type": "external" } ], "mass": 63585.0, "length": 565, "protein_name": "Transmembrane 7 superfamily member 3", "gene_name": "Tm7sf3", "organism": "Rat", "refseq_name": "transmembrane 7 superfamily member 3 precursor", "refseq_ac": [ { "id": "NP_001011970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011970", "type": "external" } ], "gene_names_uniprotkb": "Tm7sf3", "gene_names_refseq": "Tm7sf3", "protein_names_uniprotkb": "Transmembrane 7 superfamily member 3", "protein_names_refseq": "transmembrane 7 superfamily member 3 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:297725)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the inhibition of cytokine-induced death of pancreatic beta cells (By similarity). Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0043069 negative regulation of programmed cell death;GO:0034620 cellular response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVF4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVG6-1", "uniprot_id": [ { "id": "PRR5_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVG6", "type": "external" } ], "mass": 42540.0, "length": 387, "protein_name": "Proline-rich protein 5", "gene_name": "Prr5", "organism": "Rat", "refseq_name": "proline-rich protein 5", "refseq_ac": [ { "id": "NP_001012121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012121", "type": "external" } ], "gene_names_uniprotkb": "Prr5; Protor1", "gene_names_refseq": "Protor1; Prr5", "protein_names_uniprotkb": "Proline-rich protein 5; Protein observed with Rictor-1; Protor-1", "protein_names_refseq": "proline rich 5 (renal); proline-rich protein 5; protein observed with Rictor-1; protor-1", "tax_id": 10116, "disease": "", "pathway": " (rno:315189); (R-RNO-1257604); (R-RNO-389357); (R-RNO-5218920); (R-RNO-6804757); (R-RNO-9856530)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031932 TORC2 complex", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0038203 TORC2 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVG6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVJ4-1", "uniprot_id": [ { "id": "RELL2_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVJ4", "type": "external" } ], "mass": 32134.0, "length": 302, "protein_name": "RELT-like protein 2", "gene_name": "Rell2", "organism": "Rat", "refseq_name": "RELT-like protein 2", "refseq_ac": [ { "id": "NP_001014171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014171", "type": "external" } ], "gene_names_uniprotkb": "Rell2", "gene_names_refseq": "RGD1305276; Rell2", "protein_names_uniprotkb": "RELT-like protein 2", "protein_names_refseq": "RELT-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361313)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0010811 positive regulation of cell-substrate adhesion;GO:1900745 positive regulation of p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVJ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVM3-1", "uniprot_id": [ { "id": "RETR1_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVM3", "type": "external" } ], "mass": 52782.0, "length": 480, "protein_name": "Reticulophagy regulator 1", "gene_name": "Retreg1; Zfp622", "organism": "Rat", "refseq_name": "reticulophagy regulator 1", "refseq_ac": [ { "id": "NP_001030084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030084", "type": "external" } ], "gene_names_uniprotkb": "Retreg1; Zfp622; Fam134b; Retreg1; Zfp622l1; Zfp622", "gene_names_refseq": "Fam134b; Retreg1", "protein_names_uniprotkb": "Reticulophagy regulator 1; Reticulophagy receptor 1", "protein_names_refseq": "family with sequence similarity 134, member B; protein FAM134B; reticulophagy receptor 1; reticulophagy receptor FAM134B; reticulophagy regulator 1", "tax_id": 10116, "disease": "hereditary sensory and autonomic neuropathy type 2B (Disease Ontology:DOID:0070150); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (rno:619558)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "32086669;32716134;34212292;36056188", "class_list": "", "function": "Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Active under basal conditions. Required for collagen quality control in a LIR motif-dependent manner. Required for long-term survival of nociceptive and autonomic ganglion neurons., [UniProtKB, UniProtKB, UniProtKB]; FAM134B Attenuates Seizure-Induced Apoptosis and Endoplasmic Reticulum Stress in Hippocampal Neurons by Promoting Autophagy., [RefSeq, PubMed]; FAM134B-Mediated ER-Phagy in Mg(2+)-Free Solution-Induced Mitochondrial Calcium Homeostasis and Cell Death in Epileptic Hippocampal Neurons., [RefSeq, PubMed]; MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B., [RefSeq, PubMed]; O-GlcNAc transferase regulates intervertebral disc degeneration by targeting FAM134B-mediated ER-phagy., [RefSeq, PubMed]; Pre-60S-associated cytoplasmic factor involved in the cytoplasmic maturation of the 60S subunit., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140506 endoplasmic reticulum-autophagosome adaptor activity;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005801 cis-Golgi network;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0050872 white fat cell differentiation;GO:0019233 sensory perception of pain;GO:0043524 negative regulation of neuron apoptotic process;GO:0006914 autophagy;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5FVM3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5FVR0-1", "uniprot_id": [ { "id": "TIMD2_RAT", "url": "https://www.uniprot.org/uniprot/Q5FVR0", "type": "external" } ], "mass": 38544.0, "length": 349, "protein_name": "T-cell immunoglobulin and mucin domain-containing protein 2", "gene_name": "Timd2", "organism": "Rat", "refseq_name": "T-cell immunoglobulin and mucin domain-containing protein 2 precursor", "refseq_ac": [ { "id": "NP_001013877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013877", "type": "external" } ], "gene_names_uniprotkb": "Timd2; Tim2", "gene_names_refseq": "Tim2; Timd2", "protein_names_uniprotkb": "T-cell immunoglobulin and mucin domain-containing protein 2; T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2; TIM-2; TIMD-2", "protein_names_refseq": "T-cell immunoglobulin and mucin domain-containing protein 2 precursor; T-cell immunoglobulin and mucin domain-containing protein 2; T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2; TIM-2; TIMD-2", "tax_id": 10116, "disease": "essential hypertension (Disease Ontology:DOID:10825); hydronephrosis (Disease Ontology:DOID:11111); acute kidney tubular necrosis (Disease Ontology:DOID:12556); renovascular hypertension (Disease Ontology:DOID:1591); hyperuricemia (Disease Ontology:DOID:1920); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); atopic dermatitis (Disease Ontology:DOID:3310); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (rno:287222)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 1, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070287 ferritin receptor activity;GO:0001618 virus receptor activity;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0006826 iron ion transport;GO:0033005 positive regulation of mast cell activation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5FVR0-1", "record_type": "protein", "filter_code": "0000000.1000011.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5GH60-1", "uniprot_id": [ { "id": "XKR2_RAT", "url": "https://www.uniprot.org/uniprot/Q5GH60", "type": "external" } ], "mass": 52048.0, "length": 448, "protein_name": "XK-related protein 2", "gene_name": "Xkrx", "organism": "Rat", "refseq_name": "XK-related protein 2", "refseq_ac": [ { "id": "NP_001012230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012230", "type": "external" } ], "gene_names_uniprotkb": "Xkrx; Xkr2; Xrg2", "gene_names_refseq": "XRG2; Xkrx", "protein_names_uniprotkb": "XK-related protein 2; X Kell blood group-related, X-linked", "protein_names_refseq": "X Kell blood group precursor related X linked; XK, Kell blood group complex subunit-related, X-linked; XK-related protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:497101)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5GH60-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZE5-1", "uniprot_id": [ { "id": "TMM17_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZE5", "type": "external" } ], "mass": 22555.0, "length": 198, "protein_name": "Transmembrane protein 17", "gene_name": "Tmem17", "organism": "Rat", "refseq_name": "transmembrane protein 17", "refseq_ac": [ { "id": "NP_001010961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010961", "type": "external" } ], "gene_names_uniprotkb": "Tmem17", "gene_names_refseq": "Tmem17", "protein_names_uniprotkb": "Transmembrane protein 17", "protein_names_refseq": "transmembrane protein 17", "tax_id": 10116, "disease": "", "pathway": " (rno:360985)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0036038 MKS complex;GO:0060170 ciliary membrane;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0060271 cilium assembly;GO:0007224 smoothened signaling pathway;GO:1905515 non-motile cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5HZE5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZV9-1", "uniprot_id": [ { "id": "PP1R7_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZV9", "type": "external" } ], "mass": 41297.0, "length": 360, "protein_name": "Protein phosphatase 1 regulatory subunit 7", "gene_name": "AABR07068351.1; Ppp1r7", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 7", "refseq_ac": [ { "id": "NP_001009825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009825", "type": "external" } ], "gene_names_uniprotkb": "AABR07068351.1; Ppp1r7; AABR07068351.1; Ppp1r7; Sds22", "gene_names_refseq": "Ppp1r7; Sds22", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 7; Protein phosphatase 1 regulatory subunit 22", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 22; protein phosphatase 1 regulatory subunit 7; protein phosphatase 1, regulatory (inhibitor) subunit 7", "tax_id": 10116, "disease": "", "pathway": " (rno:301618)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12226088;12555814;22673903;7498485", "class_list": "", "function": "Conserved portion of Sds22 folds into a curved superhelix; demonstrate that mutation to alanine of any of eight residues at the concave surface of this superhelix thwarts the interaction with PP1 [Sds22], [RefSeq, PubMed]; Multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 are found in rat liver nuclei, [RefSeq, PubMed]; Regulatory subunit of protein phosphatase 1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5HZV9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5HZY2-1", "uniprot_id": [ { "id": "SAR1B_RAT", "url": "https://www.uniprot.org/uniprot/Q5HZY2", "type": "external" } ], "mass": 22410.0, "length": 198, "protein_name": "Small COPII coat GTPase SAR1B", "gene_name": "Sar1b", "organism": "Rat", "refseq_name": "small COPII coat GTPase SAR1B", "refseq_ac": [ { "id": "NP_001009622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009622", "type": "external" } ], "gene_names_uniprotkb": "Sar1b", "gene_names_refseq": "SARA1B; Sar1b; Sara2", "protein_names_uniprotkb": "Small COPII coat GTPase SAR1B; 3.6.5.2", "protein_names_refseq": "GTP-binding protein SAR1b; SAR1 gene homolog B; SAR1 homolog B; small COPII coat GTPase SAR1B", "tax_id": 10116, "disease": "chylomicron retention disease (Disease Ontology:DOID:0060357)", "pathway": " (rno:287276); (R-RNO-204005); (R-RNO-2132295); (R-RNO-5694530); (R-RNO-8963888); (R-RNO-983170)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "21480366;22303004;22484643", "class_list": "", "function": "Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol enabling it to bind to endoplasmic reticulum (ER) and bud the pre-chylomicron transport vesicle., [RefSeq, PubMed]; Sar1 recruitment to the endoplasmic reticulum-membrane is sensitive to H89-sensitive kinase activation, indicating the first step in transport vesicle formation occurs under kinase regulation, [RefSeq, PubMed]; Sar1 translocation onto the endoplasmic reticulum was modulated by endoplasmic reticulum-resident G(i2), [RefSeq, PubMed]; Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII. The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi. In contrast to SAR1A, SAR1B specifically interacts with the cargo receptor SURF4 to mediate the transport of lipid-carrying lipoproteins including APOB and APOA1 from the endoplasmic reticulum to the Golgi and thereby, indirectly regulates lipid homeostasis. In addition to its role in vesicle trafficking, can also function as a leucine sensor regulating TORC1 signaling and more indirectly cellular metabolism, growth and survival. In absence of leucine, interacts with the GATOR2 complex via MIOS and inhibits TORC1 signaling. The binding of leucine abrogates the interaction with GATOR2 and the inhibition of the TORC1 signaling. This function is completely independent of the GTPase activity of SAR1B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity;GO:0140785 amino acid sensor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032580 Golgi cisterna membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0032368 regulation of lipid transport;GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0042953 lipoprotein transport;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5HZY2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0E9-1", "uniprot_id": [ { "id": "S47A1_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0E9", "type": "external" } ], "mass": 61440.0, "length": 566, "protein_name": "Multidrug and toxin extrusion protein 1", "gene_name": "Slc47a1", "organism": "Rat", "refseq_name": "multidrug and toxin extrusion protein 1", "refseq_ac": [ { "id": "NP_001014140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014140", "type": "external" } ], "gene_names_uniprotkb": "Slc47a1; Mate1", "gene_names_refseq": "MATE1; RGD1311123; Slc47a1", "protein_names_uniprotkb": "Multidrug and toxin extrusion protein 1; MATE-1; Solute carrier family 47 member 1; rMATE-1", "protein_names_refseq": "MATE-1; multidrug and toxin extrusion protein 1; rMATE-1; solute carrier family 47 (multidrug and toxin extrusion), member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:360539); (R-RNO-549127)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "16850272;16928787;17047166;17296166;17327464;17582384;17616214;23182769;25486332;29346429;29393594;30951542", "class_list": "", "function": "Although multiple factors may influence renal handling of drugs, these observations can be accounted for, at least in part, by downregulation of Mate1-mediated apical efflux from tubular cells and Oct2-mediated basolateral uptake. Our results suggest that hyperuricemia could alter the disposition of drugs that are substrates of Mate1 and/or Oct2. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibitory effect of atenolol on urinary excretion of metformin via down-regulating MATE1 expression in the kidney of rats, [RefSeq, PubMed]; MATE1 is expressed in the renal proximal tubules and can mediate the transport of various organic cations and cephalexin using an oppositely directed H+ gradient, [RefSeq, PubMed]; Mechanism involved in further increasing biliary ADMA levels in sham and I/R groups treated with OCA appears to be MATE-1-dependent Publication Status: Online-Only, [RefSeq, PubMed]; Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:17047166). Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16850272, PubMed:16928787, PubMed:17047166, PubMed:17327464, PubMed:17582384). Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16850272, PubMed:16928787, PubMed:17047166, PubMed:17327464, PubMed:17582384). May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Renal mRNA level of multidrug and toxin extrusions-1 did not show an age-related increase; the increase in creatinine clearance highly contributed to the age-related increase in urinary creatinine excretion compared to mRNA levels of Oct2 and Mate1, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 31, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KKE7", "ec_number_list": [], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0015234 thiamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0031982 vesicle", "go_biological_process": "GO:0015695 organic cation transport;GO:0055085 transmembrane transport;GO:0098655 monoatomic cation transmembrane transport;GO:0006812 monoatomic cation transport;GO:1902475 L-alpha-amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q5I0E9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5I0H9-1", "uniprot_id": [ { "id": "PDIA5_RAT", "url": "https://www.uniprot.org/uniprot/Q5I0H9", "type": "external" } ], "mass": 59399.0, "length": 517, "protein_name": "Protein disulfide-isomerase A5", "gene_name": "Pdia5", "organism": "Rat", "refseq_name": "protein disulfide-isomerase A5 precursor", "refseq_ac": [ { "id": "NP_001014147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014147", "type": "external" } ], "gene_names_uniprotkb": "Pdia5", "gene_names_refseq": "Pdia5", "protein_names_uniprotkb": "Protein disulfide-isomerase A5; 5.3.4.1", "protein_names_refseq": "protein disulfide isomerase-associated 5; protein disulfide-isomerase A5 precursor; protein disulfide-isomerase A5-like; protein disulfide-isomerase A5", "tax_id": 10116, "disease": "", "pathway": " (rno:360722)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5I0H9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5IRJ7-1", "uniprot_id": [ { "id": "PROF4_RAT", "url": "https://www.uniprot.org/uniprot/Q5IRJ7", "type": "external" } ], "mass": 14421.0, "length": 129, "protein_name": "Profilin-4", "gene_name": "Pfn4", "organism": "Rat", "refseq_name": "profilin-4", "refseq_ac": [ { "id": "NP_001009503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009503", "type": "external" } ], "gene_names_uniprotkb": "Pfn4", "gene_names_refseq": "Pfn4", "protein_names_uniprotkb": "Profilin-4; Profilin IV", "protein_names_refseq": "profilin IV; profilin-4", "tax_id": 10116, "disease": "amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (rno:494222)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15591451;19419568", "class_list": "", "function": "Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis (By similarity). Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Contrary to other profilin family members, does not bind to actin in vitro (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003785 actin monomer binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005938 cell cortex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0001675 acrosome assembly;GO:1905198 manchette assembly;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5IRJ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5J3L6-1", "uniprot_id": [ { "id": "VR100_RAT", "url": "https://www.uniprot.org/uniprot/Q5J3L6", "type": "external" } ], "mass": 37396.0, "length": 326, "protein_name": "Vomeronasal type-1 receptor 100", "gene_name": "Vom1r100", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vom1r100; V1ra12; Vnr3", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 100; Pheromone receptor VN3; Vomeronasal receptor 3; Vomeronasal type-1 receptor A12", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:297439)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7585937", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62852", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5J3L6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5J3M3-1", "uniprot_id": [ { "id": "VR101_RAT", "url": "https://www.uniprot.org/uniprot/Q5J3M3", "type": "external" } ], "mass": 35513.0, "length": 310, "protein_name": "Vomeronasal type-1 receptor 101", "gene_name": "Vom1r101", "organism": "Rat", "refseq_name": "vomeronasal type-1 receptor 101", "refseq_ac": [ { "id": "NP_775135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775135", "type": "external" } ], "gene_names_uniprotkb": "Vom1r101; V1rb13; V1rb7", "gene_names_refseq": "V1rb13; V1rb7; VN7; Vnr7; Vom1r101", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 101; Pheromone receptor VN7; Vomeronasal receptor 7; Vomeronasal type-1 receptor B13", "protein_names_refseq": "pheromone receptor VN7; putative pheromone receptor VN7; vomernasal 1 receptor Vom1r101; vomeronasal 1 receptor, B7; vomeronasal V1r-type receptor V1rb13; vomeronasal receptor 7; vomeronasal type-1 receptor 101; vomeronasal type-1 receptor B13", "tax_id": 10116, "disease": "", "pathway": " (rno:286892)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7585937", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q62851", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5J3M3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7T2-1", "uniprot_id": [ { "id": "SPRY7_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7T2", "type": "external" } ], "mass": 21681.0, "length": 196, "protein_name": "SPRY domain-containing protein 7", "gene_name": "Spryd7", "organism": "Rat", "refseq_name": "SPRY domain-containing protein 7", "refseq_ac": [ { "id": "NP_001009635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009635", "type": "external" } ], "gene_names_uniprotkb": "Spryd7; Clld6", "gene_names_refseq": "Clld6; RGD1306437; Spryd7", "protein_names_uniprotkb": "SPRY domain-containing protein 7; CLL deletion region gene 6 protein homolog; Chronic lymphocytic leukemia deletion region gene 6 protein homolog", "protein_names_refseq": "CLL deletion region gene 6 protein homolog; SPRY domain-containing protein 7; chronic lymphocytic leukemia deletion region gene 6 protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:290303)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7T2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7U7-1", "uniprot_id": [ { "id": "VSTM5_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7U7", "type": "external" } ], "mass": 22486.0, "length": 199, "protein_name": "V-set and transmembrane domain-containing protein 5", "gene_name": "Vstm5", "organism": "Rat", "refseq_name": "V-set and transmembrane domain-containing protein 5 precursor", "refseq_ac": [ { "id": "NP_001138342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138342", "type": "external" } ], "gene_names_uniprotkb": "Vstm5", "gene_names_refseq": "Vstm5", "protein_names_uniprotkb": "V-set and transmembrane domain-containing protein 5", "protein_names_refseq": "V-set and transmembrane domain-containing protein 5 precursor; V-set and transmembrane domain-containing protein 5; hypothetical gene supported by BC088439", "tax_id": 10116, "disease": "", "pathway": " (rno:500947)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0006955 immune response;GO:0046847 filopodium assembly;GO:0051260 protein homooligomerization;GO:0021517 ventral spinal cord development;GO:1904891 positive regulation of excitatory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7U7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M7V1-1", "uniprot_id": [ { "id": "TRI13_RAT", "url": "https://www.uniprot.org/uniprot/Q5M7V1", "type": "external" } ], "mass": 46815.0, "length": 407, "protein_name": "E3 ubiquitin-protein ligase TRIM13", "gene_name": "Trim13", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM13", "refseq_ac": [ { "id": "NP_001012210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012210", "type": "external" } ], "gene_names_uniprotkb": "Trim13; Rfp2", "gene_names_refseq": "Trim13", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM13; 2.3.2.27; Putative tumor suppressor RFP2; RING-type E3 ubiquitin transferase TRIM13; Ret finger protein 2; Tripartite motif-containing protein 13", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM13; RING-type E3 ubiquitin transferase TRIM13; putative tumor suppressor RFP2; ret finger protein 2; tripartite motif protein 13; tripartite motif-containing protein 13", "tax_id": 10116, "disease": "", "pathway": " (rno:364398)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation. Participates as well in T-cell receptor-mediated NF-kappa-B activation. In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061659 ubiquitin-like protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M7V1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M856-1", "uniprot_id": [ { "id": "SPC25_RAT", "url": "https://www.uniprot.org/uniprot/Q5M856", "type": "external" } ], "mass": 26189.0, "length": 226, "protein_name": "Kinetochore protein Spc25", "gene_name": "Spc25", "organism": "Rat", "refseq_name": "kinetochore protein Spc25", "refseq_ac": [ { "id": "NP_001009654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009654", "type": "external" } ], "gene_names_uniprotkb": "Spc25; Spbc25", "gene_names_refseq": "RGD1307811; Spbc25; Spc25", "protein_names_uniprotkb": "Kinetochore protein Spc25", "protein_names_refseq": "SPC25, NDC80 kinetochore complex component, homolog; kinetochore protein Spc25; spindle pole body component 25 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:295661); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000776 kinetochore;GO:0000940 outer kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M856-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M962-1", "uniprot_id": [ { "id": "TM204_RAT", "url": "https://www.uniprot.org/uniprot/Q5M962", "type": "external" } ], "mass": 24701.0, "length": 226, "protein_name": "Transmembrane protein 204", "gene_name": "Tmem204", "organism": "Rat", "refseq_name": "transmembrane protein 204 precursor", "refseq_ac": [ { "id": "NP_001009620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009620", "type": "external" } ], "gene_names_uniprotkb": "Tmem204; Clp24", "gene_names_refseq": "Tmem204", "protein_names_uniprotkb": "Transmembrane protein 204; Claudin-like protein 24", "protein_names_refseq": "claudin-like protein 24; transmembrane protein 204 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:287129)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0051145 smooth muscle cell differentiation;GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway;GO:0001945 lymph vessel development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M962-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M965-1", "uniprot_id": [ { "id": "THG1_RAT", "url": "https://www.uniprot.org/uniprot/Q5M965", "type": "external" } ], "mass": 34850.0, "length": 298, "protein_name": "Probable tRNA(His) guanylyltransferase", "gene_name": "Thg1l", "organism": "Rat", "refseq_name": "probable tRNA(His) guanylyltransferase", "refseq_ac": [ { "id": "NP_001013988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013988", "type": "external" } ], "gene_names_uniprotkb": "Thg1l", "gene_names_refseq": "Thg1l", "protein_names_uniprotkb": "Probable tRNA(His) guanylyltransferase; 2.7.7.79; tRNA-histidine guanylyltransferase", "protein_names_refseq": "probable tRNA(His) guanylyltransferase", "tax_id": 10116, "disease": "autosomal recessive cerebellar ataxia (Disease Ontology:DOID:0050950); autosomal recessive spinocerebellar ataxia 28 (Disease Ontology:DOID:0070409); cancer (Disease Ontology:DOID:162)", "pathway": " (rno:303067)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21784897", "class_list": "", "function": "Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; IHG-1 increases mitochondrial biogenesis by promoting PGC-1alpha-dependent processes, potentially contributing to the pathogenesis of renal fibrosis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.79", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.79", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:1990234 transferase complex;GO:0005739 mitochondrion", "go_biological_process": "GO:1990046 stress-induced mitochondrial fusion;GO:0006979 response to oxidative stress;GO:0008033 tRNA processing;GO:0051289 protein homotetramerization;GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5M965-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5M9I5-1", "uniprot_id": [ { "id": "QCR6_RAT", "url": "https://www.uniprot.org/uniprot/Q5M9I5", "type": "external" } ], "mass": 10424.0, "length": 89, "protein_name": "Cytochrome b-c1 complex subunit 6, mitochondrial", "gene_name": "Uqcrh", "organism": "Rat", "refseq_name": "cytochrome b-c1 complex subunit 6, mitochondrial", "refseq_ac": [ { "id": "NP_001009480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009480", "type": "external" } ], "gene_names_uniprotkb": "Uqcrh", "gene_names_refseq": "Uqcrh", "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit 6, mitochondrial; Complex III subunit 6; Complex III subunit VIII; Cytochrome c1 non-heme 11 kDa protein; Mitochondrial hinge protein; Ubiquinol-cytochrome c reductase complex 11 kDa protein", "protein_names_refseq": "complex III subunit 6; complex III subunit VIII; cytochrome b-c1 complex subunit 6, mitochondrial; cytochrome c1 non-heme 11 kDa protein; mitochondrial hinge protein; ubiquinol-cytochrome c reductase complex 11 kDa protein", "tax_id": 10116, "disease": "mitochondrial complex III deficiency (Disease Ontology:DOID:0111139)", "pathway": " (rno:366448); (R-RNO-611105); (R-RNO-9865881)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0008121 quinol-cytochrome-c reductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045275 respiratory chain complex III", "go_biological_process": "GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5M9I5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPM8-1", "uniprot_id": [ { "id": "PP4P1_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPM8", "type": "external" } ], "mass": 29993.0, "length": 284, "protein_name": "Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "gene_name": "Pip4p1", "organism": "Rat", "refseq_name": "type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "refseq_ac": [ { "id": "NP_001014255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014255", "type": "external" } ], "gene_names_uniprotkb": "Pip4p1; Tmem55b", "gene_names_refseq": "Pip4p1; RGD1307475; Tmem55b", "protein_names_uniprotkb": "Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; 3.1.3.78; PtdIns-4,5-P2 4-Ptase I; Transmembrane protein 55B; Type 1 PtdIns-4,5-P2 4-Ptase", "protein_names_refseq": "PtdIns-4,5-P(2) 4-phosphatase type I; ptdIns-4,5-P2 4-Ptase I; transmembrane protein 55B-like; transmembrane protein 55B; type 1 PtdIns-4,5-P2 4-Ptase; type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "tax_id": 10116, "disease": "", "pathway": " (rno:364298); (R-RNO-6811555); (R-RNO-8847453)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (By similarity). May play a role in the regulation of cellular cholesterol metabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.78", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.78", "type": "external" } ], "go_molecular_function": "GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0008203 cholesterol metabolic process;GO:0032418 lysosome localization;GO:0046856 phosphatidylinositol dephosphorylation;GO:0006991 response to sterol depletion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PPM8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PPN2-1", "uniprot_id": [ { "id": "RPP25_RAT", "url": "https://www.uniprot.org/uniprot/Q5PPN2", "type": "external" } ], "mass": 20939.0, "length": 199, "protein_name": "Ribonuclease P protein subunit p25", "gene_name": "Rpp25", "organism": "Rat", "refseq_name": "ribonuclease P protein subunit p25", "refseq_ac": [ { "id": "NP_001012124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012124", "type": "external" } ], "gene_names_uniprotkb": "Rpp25", "gene_names_refseq": "Rpp25", "protein_names_uniprotkb": "Ribonuclease P protein subunit p25; RNase P protein subunit p25", "protein_names_refseq": "RNase P protein subunit p25; ribonuclease P 25 subunit; ribonuclease P and MRP subunit p25; ribonuclease P protein subunit p25; ribonuclease P/MRP 25 subunit", "tax_id": 10116, "disease": "autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (rno:315705); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005654 nucleoplasm;GO:0000172 ribonuclease MRP complex", "go_biological_process": "GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5PPN2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5PT50-1", "uniprot_id": [ { "id": "NTCP7_RAT", "url": "https://www.uniprot.org/uniprot/Q5PT50", "type": "external" } ], "mass": 37316.0, "length": 340, "protein_name": "Sodium/bile acid cotransporter 7", "gene_name": "Slc10a7", "organism": "Rat", "refseq_name": "sodium/bile acid cotransporter 7", "refseq_ac": [ { "id": "NP_001010948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010948", "type": "external" } ], "gene_names_uniprotkb": "Slc10a7; P7", "gene_names_refseq": "P7; Slc10a7", "protein_names_uniprotkb": "Sodium/bile acid cotransporter 7; Na(+)/bile acid cotransporter 7; Solute carrier family 10 member 7", "protein_names_refseq": "Na(+)/bile acid cotransporter 7; sodium/bile acid cotransporter 7; solute carrier family 10 (sodium/bile acid cotransporter family), member 7-like", "tax_id": 10116, "disease": "syndrome (Disease Ontology:DOID:225)", "pathway": " (rno:291942)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17628207", "class_list": "", "function": "Does not show transport activity towards bile acids or steroid sulfates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization. Also involved in the regulation of cellular calcium homeostasis. Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Molecular characterization and expression analysis of a novel member of the SLC10 family, SLC10A7, previously known as C4orf13, is reported, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0060348 bone development;GO:0006814 sodium ion transport;GO:0030210 heparin proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5PT50-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QD21-1", "uniprot_id": [ { "id": "TAA7C_RAT", "url": "https://www.uniprot.org/uniprot/Q5QD21", "type": "external" } ], "mass": 40303.0, "length": 358, "protein_name": "Trace amine-associated receptor 7c", "gene_name": "Taar7c", "organism": "Rat", "refseq_name": "trace amine-associated receptor 7c", "refseq_ac": [ { "id": "NP_001009975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009975", "type": "external" } ], "gene_names_uniprotkb": "Taar7c", "gene_names_refseq": "Taar7c", "protein_names_uniprotkb": "Trace amine-associated receptor 7c; TaR-7c; Trace amine receptor 7c", "protein_names_refseq": "taR-7c; trace amine associated receptor 7c; trace amine receptor 7c; trace amine-associated receptor 7c", "tax_id": 10116, "disease": "", "pathway": " (rno:494535)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15718104;17556730", "class_list": "", "function": "Expression of Taar family members is limited to specific tissue subpopulations and developmental stages in mouse., [RefSeq, PubMed]; Olfactory receptor specific for N,N-dimethylalkylamines trace amines. Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors. Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5QD21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QD25-1", "uniprot_id": [ { "id": "TAAR2_RAT", "url": "https://www.uniprot.org/uniprot/Q5QD25", "type": "external" } ], "mass": 38557.0, "length": 339, "protein_name": "Trace amine-associated receptor 2", "gene_name": "Taar2", "organism": "Rat", "refseq_name": "trace amine-associated receptor 2", "refseq_ac": [ { "id": "NP_001008512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008512", "type": "external" } ], "gene_names_uniprotkb": "Taar2; Gpr58", "gene_names_refseq": "Gpr58; Taar2", "protein_names_uniprotkb": "Trace amine-associated receptor 2; G protein-coupled receptor 58; TaR-2; Trace amine receptor 2", "protein_names_refseq": "G-protein coupled receptor 58; taR-2; trace amine receptor 2; trace amine-associated receptor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:294121); (R-RNO-375280)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15718104", "class_list": "", "function": "Orphan olfactory receptor specific for trace amines. Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors. Ligand-binding causes a conformation change that triggers signaling via the G(s)-class of G proteins which activate adenylate cyclase (By similarity). May also be required to provide olfactory input into limbic brain areas to regulate emotional behaviors likely via modulation of the dopamine system (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5QD25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RJP7-1", "uniprot_id": [ { "id": "PGFRL_RAT", "url": "https://www.uniprot.org/uniprot/Q5RJP7", "type": "external" } ], "mass": 41933.0, "length": 375, "protein_name": "Platelet-derived growth factor receptor-like protein", "gene_name": "Pdgfrl", "organism": "Rat", "refseq_name": "platelet-derived growth factor receptor-like protein precursor", "refseq_ac": [ { "id": "NP_001011921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011921", "type": "external" } ], "gene_names_uniprotkb": "Pdgfrl", "gene_names_refseq": "Pdgfrl", "protein_names_uniprotkb": "Platelet-derived growth factor receptor-like protein; PDGFR-like protein", "protein_names_refseq": "PDGFR-like protein; platelet-derived growth factor receptor-like protein precursor; platelet-derived growth factor receptor-like protein", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:290771)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21092323", "class_list": "", "function": "Data demonstrate that in RBA-1 cells, activation of c-Jun/AP-1 by a CaMKII-dependent PI3K/Akt-JNK activation mediated through transactivation of PDGFR is essential for up-regulation of MMP-9 and cell migration induced by lipoteichoic acid. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005017 platelet-derived growth factor receptor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5RJP7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RK30-1", "uniprot_id": [ { "id": "SBDS_RAT", "url": "https://www.uniprot.org/uniprot/Q5RK30", "type": "external" } ], "mass": 28752.0, "length": 250, "protein_name": "Ribosome maturation protein SBDS", "gene_name": "Sbds", "organism": "Rat", "refseq_name": "ribosome maturation protein SBDS", "refseq_ac": [ { "id": "NP_001008290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008290", "type": "external" } ], "gene_names_uniprotkb": "Sbds", "gene_names_refseq": "Sbds", "protein_names_uniprotkb": "Ribosome maturation protein SBDS; Shwachman-Bodian-Diamond syndrome protein homolog", "protein_names_refseq": "SBDS ribosome assembly guanine nucleotide exchange factor; Shwachman-Bodian-Diamond syndrome homolog; ribosome maturation protein SBDS; shwachman-Bodian-Diamond syndrome protein homolog", "tax_id": 10116, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479); neuronal ceroid lipofuscinosis 3 (Disease Ontology:DOID:0110731); aplastic anemia (Disease Ontology:DOID:12449)", "pathway": " (rno:288615)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019843 rRNA binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002244 hematopoietic progenitor cell differentiation;GO:0006364 rRNA processing;GO:0030282 bone mineralization;GO:0007052 mitotic spindle organization;GO:0048539 bone marrow development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RK30-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKI7-1", "uniprot_id": [ { "id": "S7A13_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKI7", "type": "external" } ], "mass": 53551.0, "length": 479, "protein_name": "Solute carrier family 7 member 13", "gene_name": "Slc7a13", "organism": "Rat", "refseq_name": "solute carrier family 7 member 13", "refseq_ac": [ { "id": "NP_001012100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012100", "type": "external" } ], "gene_names_uniprotkb": "Slc7a13", "gene_names_refseq": "Slc7a13", "protein_names_uniprotkb": "Solute carrier family 7 member 13; Sodium-independent aspartate/glutamate transporter 1", "protein_names_refseq": "sodium-independent aspartate/glutamate transporter 1; solute carrier family 7 (anionic amino acid transporter), member 13; solute carrier family 7 member 13; solute carrier family 7, (cationic amino acid transporter, y+ system) member 13", "tax_id": 10116, "disease": "", "pathway": " (rno:313089)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Associates with SLC3A1/rBAT to form a functional heterodimeric complex that transports anionic and neutral amino acids across the apical plasma membrane of renal epithelium. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. May act as a major transporter for L-cystine in late proximal tubules, ensuring its reabsorption from the luminal fluid in exchange for cytosolic L-glutamate or L-aspartate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0046982 protein heterodimerization activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015811 L-cystine transport;GO:0003333 amino acid transmembrane transport;GO:0015810 aspartate transmembrane transport;GO:0015813 L-glutamate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RKI7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5RKL7-1", "uniprot_id": [ { "id": "S35E4_RAT", "url": "https://www.uniprot.org/uniprot/Q5RKL7", "type": "external" } ], "mass": 37041.0, "length": 350, "protein_name": "Solute carrier family 35 member E4", "gene_name": "Slc35e4", "organism": "Rat", "refseq_name": "solute carrier family 35 member E4", "refseq_ac": [ { "id": "NP_695228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_695228", "type": "external" } ], "gene_names_uniprotkb": "Slc35e4", "gene_names_refseq": "Slc35e4", "protein_names_uniprotkb": "Solute carrier family 35 member E4", "protein_names_refseq": "putative phosphate-phosphoenolpyruvate translocator; solute carrier family 35 member E4", "tax_id": 10116, "disease": "", "pathway": " (rno:266687)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative transporter., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5RKL7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1X0-1", "uniprot_id": [ { "id": "TAF11_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1X0", "type": "external" } ], "mass": 23306.0, "length": 211, "protein_name": "Transcription initiation factor TFIID subunit 11", "gene_name": "Taf11", "organism": "Rat", "refseq_name": "transcription initiation factor TFIID subunit 11", "refseq_ac": [ { "id": "NP_001008351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008351", "type": "external" } ], "gene_names_uniprotkb": "Taf11", "gene_names_refseq": "Taf11", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 11; TAF(II)28; TAFII-28; TAFII28; TFIID subunit p30-beta; Transcription initiation factor TFIID 28 kDa subunit", "protein_names_refseq": "TAF(II)28; TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor; TAFII-28; TAFII28; TATA box binding protein (TBP)-associated factor 11; TFIID subunit p30-beta; transcription initiation factor TFIID 28 kDa subunit; transcription initiation factor TFIID subunit 11", "tax_id": 10116, "disease": "", "pathway": " (rno:309638); (R-RNO-674695); (R-RNO-6804756); (R-RNO-6807505); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-76042)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF11, together with TAF13 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0046982 protein heterodimerization activity;GO:0046966 nuclear thyroid hormone receptor binding;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0042789 mRNA transcription by RNA polymerase II;GO:0043923 host-mediated activation of viral transcription;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U1X0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1Z2-1", "uniprot_id": [ { "id": "TPPC3_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1Z2", "type": "external" } ], "mass": 20302.0, "length": 180, "protein_name": "Trafficking protein particle complex subunit 3", "gene_name": "Trappc3", "organism": "Rat", "refseq_name": "trafficking protein particle complex subunit 3", "refseq_ac": [ { "id": "NP_001008377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008377", "type": "external" } ], "gene_names_uniprotkb": "Trappc3", "gene_names_refseq": "Trappc3", "protein_names_uniprotkb": "Trafficking protein particle complex subunit 3", "protein_names_refseq": "BET3 homolog; trafficking protein particle complex 3; trafficking protein particle complex subunit 3", "tax_id": 10116, "disease": "", "pathway": " (rno:362599); (R-RNO-204005); (R-RNO-8876198)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15728249", "class_list": "", "function": "Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus, [RefSeq, PubMed]; May play a role in vesicular transport from endoplasmic reticulum to Golgi., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0033106 cis-Golgi network membrane;GO:0030008 TRAPP complex", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006891 intra-Golgi vesicle-mediated transport;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5U1Z2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U1Z8-1", "uniprot_id": [ { "id": "PREY_RAT", "url": "https://www.uniprot.org/uniprot/Q5U1Z8", "type": "external" } ], "mass": 12652.0, "length": 112, "protein_name": "Protein preY, mitochondrial", "gene_name": "Pyurf", "organism": "Rat", "refseq_name": "protein preY, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001019541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019541", "type": "external" } ], "gene_names_uniprotkb": "Pyurf; Pigy; Prey", "gene_names_refseq": "Pigy; Prey; Pyurfl1; Pyurf", "protein_names_uniprotkb": "Protein preY, mitochondrial", "protein_names_refseq": "PIGY upstream reading frame-like 1; phosphatidylinositol glycan anchor biosynthesis, class Y; protein preY, mitochondrial precursor; protein preY, mitochondrial", "tax_id": 10116, "disease": "", "pathway": " (rno:502782)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In mitochondria, S-adenosylmethionine-dependent methyltransferase chaperone that supports both coenzyme Q biosynthesis, by stabilizing its components, such as COQ5, and NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) assembly, by stabilizing complex I assembly factors, such as NDUFAF5., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U1Z8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2R6-1", "uniprot_id": [ { "id": "P33MX_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2R6", "type": "external" } ], "mass": 32797.0, "length": 304, "protein_name": "Putative monooxygenase p33MONOX", "gene_name": "Kiaa1191; P33monox", "organism": "Rat", "refseq_name": "putative monooxygenase p33MONOX isoform 1", "refseq_ac": [ { "id": "NP_001014029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014029", "type": "external" } ], "gene_names_uniprotkb": "Kiaa1191; P33monox; Aa2-141; LOC306766", "gene_names_refseq": "Aa2-141; Kiaa1191; P33monox", "protein_names_uniprotkb": "Putative monooxygenase p33MONOX; 1.-.-.-; liver regeneration-related protein LRRG011", "protein_names_refseq": "liver regeneration-related protein LRRG011; putative monooxygenase p33MONOX isoform 1; putative monooxygenase p33MONOX", "tax_id": 10116, "disease": "", "pathway": " (rno:306766)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21153684;22673903", "class_list": "", "function": "Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7TP81", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5U2R6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2W6-1", "uniprot_id": [ { "id": "PTVO1_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2W6", "type": "external" } ], "mass": 46849.0, "length": 416, "protein_name": "Prostate tumor-overexpressed gene 1 protein homolog", "gene_name": "Ptov1", "organism": "Rat", "refseq_name": "prostate tumor-overexpressed gene 1 protein homolog", "refseq_ac": [ { "id": "NP_001008305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008305", "type": "external" } ], "gene_names_uniprotkb": "Ptov1", "gene_names_refseq": "Ptov1", "protein_names_uniprotkb": "Prostate tumor-overexpressed gene 1 protein homolog", "protein_names_refseq": "prostate tumor over expressed gene 1; prostate tumor overexpressed 1; prostate tumor-overexpressed gene 1 protein homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:292888)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2W6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U2X7-1", "uniprot_id": [ { "id": "TIM21_RAT", "url": "https://www.uniprot.org/uniprot/Q5U2X7", "type": "external" } ], "mass": 27876.0, "length": 245, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim21", "gene_name": "Timm21", "organism": "Rat", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim21 precursor", "refseq_ac": [ { "id": "NP_001008344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008344", "type": "external" } ], "gene_names_uniprotkb": "Timm21; Tim21", "gene_names_refseq": "RGD1307279; Timm21", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim21; TIM21-like protein, mitochondrial", "protein_names_refseq": "TIM21-like protein, mitochondrial; mitochondrial import inner membrane translocase subunit Tim21 precursor; mitochondrial import inner membrane translocase subunit Tim21; translocase of inner mitochondrial membrane 21 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:307210)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U2X7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5U3Y9-1", "uniprot_id": [ { "id": "TM218_RAT", "url": "https://www.uniprot.org/uniprot/Q5U3Y9", "type": "external" } ], "mass": 12479.0, "length": 115, "protein_name": "Transmembrane protein 218", "gene_name": "Tmem218", "organism": "Rat", "refseq_name": "transmembrane protein 218", "refseq_ac": [ { "id": "NP_001008326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008326", "type": "external" } ], "gene_names_uniprotkb": "Tmem218", "gene_names_refseq": "RGD1311364; Tmem218", "protein_names_uniprotkb": "Transmembrane protein 218", "protein_names_refseq": "transmembrane protein 218", "tax_id": 10116, "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); Joubert syndrome (Disease Ontology:DOID:0050777)", "pathway": " (rno:300516)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in ciliary biogenesis or function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5U3Y9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHX2-1", "uniprot_id": [ { "id": "TPRN_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHX2", "type": "external" } ], "mass": 80272.0, "length": 753, "protein_name": "Taperin", "gene_name": "Tprn", "organism": "Rat", "refseq_name": "taperin", "refseq_ac": [ { "id": "NP_001019480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019480", "type": "external" } ], "gene_names_uniprotkb": "Tprn", "gene_names_refseq": "Tprn", "protein_names_uniprotkb": "Taperin", "protein_names_refseq": "taperin", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 79 (Disease Ontology:DOID:0110526)", "pathway": " (rno:499749)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (By similarity). Recruited to sites of DNA damage and may play a role in DNA damage repair (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0003779 actin binding;GO:0008157 protein phosphatase 1 binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005902 microvillus;GO:0032420 stereocilium;GO:0120044 stereocilium base", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0060088 auditory receptor cell stereocilium organization;GO:0120045 stereocilium maintenance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XHX2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHY3-1", "uniprot_id": [ { "id": "TX19A_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHY3", "type": "external" } ], "mass": 40855.0, "length": 356, "protein_name": "Testis-expressed protein 19.1", "gene_name": "Tex19.1", "organism": "Rat", "refseq_name": "testis-expressed protein 19.1", "refseq_ac": [ { "id": "NP_001017482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017482", "type": "external" } ], "gene_names_uniprotkb": "Tex19.1; Tex19a", "gene_names_refseq": "Tex19.1; Tex19a; Tex19", "protein_names_uniprotkb": "Testis-expressed protein 19.1; Testis-expressed protein 19A; Tex19.1", "protein_names_refseq": "testis expressed gene 19.1; testis expressed gene 19; testis-expressed protein 19.1; testis-expressed protein 19A; testis-expressed sequence 1A", "tax_id": 10116, "disease": "", "pathway": " (rno:498033)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18096721", "class_list": "", "function": "Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis. Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization., [UniProtKB, UniProtKB]; Tex19 is a mammalian-specific protein duplicated in mouse and rat, renamed Tex19.1 and Tex19.2, whereas only one form is found in human., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034584 piRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0001890 placenta development;GO:0008584 male gonad development;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XHY3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XHZ9-1", "uniprot_id": [ { "id": "PCH2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XHZ9", "type": "external" } ], "mass": 48434.0, "length": 432, "protein_name": "Pachytene checkpoint protein 2 homolog", "gene_name": "Trip13", "organism": "Rat", "refseq_name": "pachytene checkpoint protein 2 homolog", "refseq_ac": [ { "id": "NP_001011930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011930", "type": "external" } ], "gene_names_uniprotkb": "Trip13; Pch2", "gene_names_refseq": "Trip13", "protein_names_uniprotkb": "Pachytene checkpoint protein 2 homolog; TR-interacting protein 13; TRIP-13; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13", "protein_names_refseq": "TR-interacting protein 13; TRIP-13; pachytene checkpoint protein 2 homolog; thyroid receptor-interacting protein 13", "tax_id": 10116, "disease": "mosaic variegated aneuploidy syndrome 3 (Disease Ontology:DOID:0080689)", "pathway": " (rno:292206)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0001673 male germ cell nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0007144 female meiosis I;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XHZ9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI37-1", "uniprot_id": [ { "id": "RT15_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI37", "type": "external" } ], "mass": 29713.0, "length": 257, "protein_name": "Small ribosomal subunit protein uS15m", "gene_name": "Mrps15", "organism": "Rat", "refseq_name": "small ribosomal subunit protein uS15m", "refseq_ac": [ { "id": "NP_001007654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007654", "type": "external" } ], "gene_names_uniprotkb": "Mrps15", "gene_names_refseq": "Mrps15", "protein_names_uniprotkb": "Small ribosomal subunit protein uS15m; 28S ribosomal protein S15, mitochondrial; MRP-S15; S15mt", "protein_names_refseq": "28S ribosomal protein S15, mitochondrial; MRP-S15; S15mt; small ribosomal subunit protein uS15m", "tax_id": 10116, "disease": "", "pathway": " (rno:298517); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005761 mitochondrial ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI37-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI70-1", "uniprot_id": [ { "id": "PCGF6_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI70", "type": "external" } ], "mass": 39706.0, "length": 351, "protein_name": "Polycomb group RING finger protein 6", "gene_name": "Pcgf6", "organism": "Rat", "refseq_name": "polycomb group RING finger protein 6", "refseq_ac": [ { "id": "NP_001013172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013172", "type": "external" } ], "gene_names_uniprotkb": "Pcgf6; Rnf134", "gene_names_refseq": "Pcgf6; Rnf134", "protein_names_uniprotkb": "Polycomb group RING finger protein 6; RING finger protein 134", "protein_names_refseq": "polycomb group RING finger protein 6; ring finger protein 134", "tax_id": 10116, "disease": "", "pathway": " (rno:309457); (R-RNO-8953750)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0031519 PcG protein complex;GO:0035102 PRC1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XI70-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XI89-1", "uniprot_id": [ { "id": "NXPE4_RAT", "url": "https://www.uniprot.org/uniprot/Q5XI89", "type": "external" } ], "mass": 61615.0, "length": 542, "protein_name": "NXPE family member 4", "gene_name": "Nxpe4", "organism": "Rat", "refseq_name": "NXPE family member 4 precursor", "refseq_ac": [ { "id": "NP_001020226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020226", "type": "external" } ], "gene_names_uniprotkb": "Nxpe4; Fam55d", "gene_names_refseq": "Fam55b; Fam55d; Nxpe4", "protein_names_uniprotkb": "NXPE family member 4; Protein FAM55D", "protein_names_refseq": "NXPE family member 4 precursor; NXPE family member 4; family with sequence similarity 55, member B; protein FAM55D", "tax_id": 10116, "disease": "", "pathway": " (rno:500991)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XI89-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIE1-1", "uniprot_id": [ { "id": "THEM6_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIE1", "type": "external" } ], "mass": 23748.0, "length": 207, "protein_name": "Protein THEM6", "gene_name": "Them6", "organism": "Rat", "refseq_name": "protein THEM6 precursor", "refseq_ac": [ { "id": "NP_001007659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007659", "type": "external" } ], "gene_names_uniprotkb": "Them6", "gene_names_refseq": "RGD1359378; Them6", "protein_names_uniprotkb": "Protein THEM6", "protein_names_refseq": "UPF0670 protein C8orf55 homolog; UPF0670 protein THEM6 homolog; mesenchymal stem cell protein DSCD75; protein THEM6 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:300015)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIE1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIF4-1", "uniprot_id": [ { "id": "SUMO3_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIF4", "type": "external" } ], "mass": 12456.0, "length": 110, "protein_name": "Small ubiquitin-related modifier 3", "gene_name": "Sumo3", "organism": "Rat", "refseq_name": "small ubiquitin-related modifier 3", "refseq_ac": [ { "id": "NP_001019466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019466", "type": "external" } ], "gene_names_uniprotkb": "Sumo3", "gene_names_refseq": "Sumo3", "protein_names_uniprotkb": "Small ubiquitin-related modifier 3; SUMO-3", "protein_names_refseq": "SMT3 suppressor of mif two 3 homolog 3; SUMO-3; small ubiquitin-related modifier 3", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:499417); (R-RNO-196791); (R-RNO-3065679); (R-RNO-3108214); (R-RNO-3232118); (R-RNO-3899300); (R-RNO-4085377); (R-RNO-4090294); (R-RNO-4551638); (R-RNO-4570464); (R-RNO-4615885); (R-RNO-5693607); (R-RNO-5696395)", "pathway_count": 13, "publication_count": 4, "publication_id_list": "18167501;20075418;22891650;24971350", "class_list": "", "function": "Considering the marked effect of SUMO conjugation on the function of target proteins, it is very likely that the postischemic activation of sumoylation has a significant effect on the fate of neurons exposed to transient ischemia., [RefSeq, PubMed]; Disruption of the retinoic acid receptor alpha gene in the testis resulted in alteration of SUMO-2/3 subcellular localization, [RefSeq, PubMed]; Exposure to moderate 30 degrees C hypothermia in rats is sufficient to markedly modify the pattern and subcellular localization of SUMO2/3 in neurons, and hypothermia triggers nuclear translocation of the SUMO-conjugating enzyme Ubc9., [RefSeq, PubMed]; These results suggest that high glucose may activate TGF- beta/Smad signaling through sumoylation of Samd4 by SUMO2/3 in mesangial cells., [RefSeq, PubMed]; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044389 ubiquitin-like protein ligase binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016605 PML body", "go_biological_process": "GO:0016925 protein sumoylation;GO:1900180 regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5XIF4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIG0-1", "uniprot_id": [ { "id": "NUDT9_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIG0", "type": "external" } ], "mass": 38562.0, "length": 350, "protein_name": "ADP-ribose pyrophosphatase", "gene_name": "Nudt9", "organism": "Rat", "refseq_name": "ADP-ribose pyrophosphatase", "refseq_ac": [ { "id": "NP_001006992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006992", "type": "external" } ], "gene_names_uniprotkb": "Nudt9", "gene_names_refseq": "Nudt9", "protein_names_uniprotkb": "ADP-ribose pyrophosphatase; 3.6.1.13; ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ADPR-PPase; Adenosine diphosphoribose pyrophosphatase; Nucleoside diphosphate-linked moiety X motif 9; Nudix motif 9", "protein_names_refseq": "ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ADP-ribose pyrophosphatase, mitochondrial; ADP-ribose pyrophosphatase; ADPR-PPase; adenosine diphosphoribose pyrophosphatase; nucleoside diphosphate-linked moiety X motif 9; nudix (nucleoside diphosphate linked moiety X)-type motif 9; nudix motif 9; nudix-type motif 9", "tax_id": 10116, "disease": "", "pathway": " (rno:305149); (R-RNO-2393930)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. Has also a weak phosphohydrolase activity against NADH and FAD (in vitro)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" }, { "id": "3.6.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.13", "type": "external" }, { "id": "3.6.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.58", "type": "external" }, { "id": "2.7.7.96", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.96", "type": "external" } ], "go_molecular_function": "GO:0047631 ADP-ribose diphosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0046032 ADP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5XIG0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIH6-1", "uniprot_id": [ { "id": "TRI54_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIH6", "type": "external" } ], "mass": 41031.0, "length": 364, "protein_name": "Tripartite motif-containing protein 54", "gene_name": "Trim54", "organism": "Rat", "refseq_name": "tripartite motif-containing protein 54", "refseq_ac": [ { "id": "NP_001013235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013235", "type": "external" } ], "gene_names_uniprotkb": "Trim54; Rnf30", "gene_names_refseq": "Rnf30; Trim54", "protein_names_uniprotkb": "Tripartite motif-containing protein 54; RING finger protein 30", "protein_names_refseq": "ring finger protein 30; tripartite motif-containing protein 54", "tax_id": 10116, "disease": "", "pathway": " (rno:362708)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "38042492", "class_list": "", "function": "May bind and stabilize microtubules during myotubes formation., [UniProtKB]; TRIM54 alleviates inflammation and apoptosis by stabilizing YOD1 in rat tendon-derived stem cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005875 microtubule associated complex;GO:0030018 Z disc", "go_biological_process": "GO:0030154 cell differentiation;GO:0045087 innate immune response;GO:0007026 negative regulation of microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XII5-1", "uniprot_id": [ { "id": "TCAB1_RAT", "url": "https://www.uniprot.org/uniprot/Q5XII5", "type": "external" } ], "mass": 58195.0, "length": 532, "protein_name": "Telomerase Cajal body protein 1", "gene_name": "Wrap53", "organism": "Rat", "refseq_name": "telomerase Cajal body protein 1", "refseq_ac": [ { "id": "NP_001007611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007611", "type": "external" } ], "gene_names_uniprotkb": "Wrap53; Tcab1; Wdr79", "gene_names_refseq": "Wdr79; Wrap53", "protein_names_uniprotkb": "Telomerase Cajal body protein 1; WD repeat-containing protein 79; WD40 repeat-containing protein antisense to TP53 gene homolog", "protein_names_refseq": "WD repeat domain 79; WD repeat-containing protein 79; WD repeat-containing protein WRAP53; WD40 repeat-containing protein antisense to TP53 gene homolog; WD40 repeat-containing protein encoded by RNA antisense to p53; telomerase Cajal body protein 1", "tax_id": 10116, "disease": "autosomal recessive dyskeratosis congenita 3 (Disease Ontology:DOID:0070019); breast cancer (Disease Ontology:DOID:1612); rectal benign neoplasm (Disease Ontology:DOID:1984); motor neuron disease (Disease Ontology:DOID:231); ovarian cancer (Disease Ontology:DOID:2394); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); hepatocellular carcinoma (Disease Ontology:DOID:684); glottis squamous cell carcinoma (Disease Ontology:DOID:7031); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (rno:287432); (R-RNO-171319); (R-RNO-174430)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity. In addition, also controls telomerase holoenzyme complex localization to Cajal body. During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity. In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies. Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks. Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0031625 ubiquitin protein ligase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016604 nuclear body;GO:0035861 site of double-strand break;GO:0015030 Cajal body;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0090666 scaRNA localization to Cajal body;GO:0034337 RNA folding;GO:0032203 telomere formation via telomerase;GO:0090671 telomerase RNA localization to Cajal body", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XII5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIL2-1", "uniprot_id": [ { "id": "P4K2B_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIL2", "type": "external" } ], "mass": 54464.0, "length": 477, "protein_name": "Phosphatidylinositol 4-kinase type 2-beta", "gene_name": "Pi4k2b", "organism": "Rat", "refseq_name": "phosphatidylinositol 4-kinase type 2-beta", "refseq_ac": [ { "id": "NP_001005883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005883", "type": "external" } ], "gene_names_uniprotkb": "Pi4k2b", "gene_names_refseq": "Pi4k2b", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase type 2-beta; 2.7.1.67; Phosphatidylinositol 4-kinase type II-beta", "protein_names_refseq": "phosphatidylinositol 4-kinase type 2-beta; phosphatidylinositol 4-kinase type II-beta", "tax_id": 10116, "disease": "", "pathway": " (rno:305419); (R-RNO-1483248); (R-RNO-1660499); (R-RNO-1660514); (R-RNO-1660516)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "16837555", "class_list": "", "function": "These results demonstrate a novel role for NCS-1 and PI4Kbeta in regulating ERK1/2 signaling and inflammatory reactions in mast cells., [RefSeq, PubMed]; Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007032 endosome organization;GO:0007030 Golgi organization;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIL2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIP1-1", "uniprot_id": [ { "id": "PELO_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIP1", "type": "external" } ], "mass": 43407.0, "length": 385, "protein_name": "Protein pelota homolog", "gene_name": "Pelo", "organism": "Rat", "refseq_name": "protein pelota homolog", "refseq_ac": [ { "id": "NP_001007635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007635", "type": "external" } ], "gene_names_uniprotkb": "Pelo", "gene_names_refseq": "Pelo", "protein_names_uniprotkb": "Protein pelota homolog", "protein_names_refseq": "pelota homolog; protein pelota homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:294754); (R-RNO-9954714)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0043022 ribosome binding;GO:0170011 stalled ribosome sensor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0022626 cytosolic ribosome;GO:1990533 Dom34-Hbs1 complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay;GO:0070651 nonfunctional rRNA decay;GO:0071025 RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5XIP1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5XIU9-1", "uniprot_id": [ { "id": "PGRC2_RAT", "url": "https://www.uniprot.org/uniprot/Q5XIU9", "type": "external" } ], "mass": 23403.0, "length": 217, "protein_name": "Membrane-associated progesterone receptor component 2", "gene_name": "Pgrmc2", "organism": "Rat", "refseq_name": "membrane-associated progesterone receptor component 2", "refseq_ac": [ { "id": "NP_001008375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008375", "type": "external" } ], "gene_names_uniprotkb": "Pgrmc2", "gene_names_refseq": "Pgrmc2", "protein_names_uniprotkb": "Membrane-associated progesterone receptor component 2", "protein_names_refseq": "membrane-associated progesterone receptor component 2; progesterone membrane binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:361940); (R-RNO-8980692); (R-RNO-9013404); (R-RNO-9013408); (R-RNO-9013423); (R-RNO-9707616)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "20977928;22673903;25253729", "class_list": "", "function": "PGRMC1 and PGRMC2 are involved in regulating entry into the G1 stage of the cell cycle., [RefSeq, PubMed]; Pgrmc1 and Pgrmc2 may play roles in neuroendocrine functions of the female rat., [RefSeq, PubMed]; Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus. Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015232 heme transmembrane transporter activity;GO:0005496 steroid binding;GO:0020037 heme binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0060612 adipose tissue development;GO:0015886 heme transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5XIU9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62649-1", "uniprot_id": [ { "id": "NNAT_RAT", "url": "https://www.uniprot.org/uniprot/Q62649", "type": "external" } ], "mass": 9220.0, "length": 81, "protein_name": "Neuronatin", "gene_name": "Nnat", "organism": "Rat", "refseq_name": "neuronatin isoform 3", "refseq_ac": [ { "id": "NP_001257796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257796", "type": "external" } ], "gene_names_uniprotkb": "Nnat", "gene_names_refseq": "Nnat; Peg5", "protein_names_uniprotkb": "Neuronatin", "protein_names_refseq": "neuronatin alpha; neuronatin isoform 3", "tax_id": 10116, "disease": "", "pathway": " (rno:94270)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "20509861;21935485;24370184;30869556;31805566;7496812;8024565", "class_list": "", "function": "Data propose that neuronatin may impact synaptic plasticity by modulating dendritic calcium levels during homeostatic plasticity, thereby potentially regulating neuronal excitability, receptor trafficking, and calcium dependent signaling., [RefSeq, PubMed]; Localization of Neuronatin in Rat Testis, Hair Follicle, Tongue, and Pancreas, [RefSeq, PubMed]; May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system., [UniProtKB]; NNAT signals were broadly observed across the developing brain on embryonic day E13.5 and gradually more localized in later stages, eventually concentrated in the alar and basal parts of the terminal hypothalamus, the alar plate of prosomere 2 of the thalamus, and the choroid plexus in the lateral and fourth ventricles on embryonic day E20.5., [RefSeq, PubMed]; Significant correlation between mechanical hyperalgesia in axotomy of sciatic nerve and the increased expression of Nnat in C-fiber and A-delta fiber of adult dorsal root ganglion neurons Publication Status: Online-Only, [RefSeq, PubMed]; Trh, Tnxa and Nnat genes were affected according to the degree of memory in male rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JPK6;Q62663", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0007420 brain development;GO:0032880 regulation of protein localization;GO:0030182 neuron differentiation;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q62649-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62689-1", "uniprot_id": [ { "id": "JAK2_RAT", "url": "https://www.uniprot.org/uniprot/Q62689", "type": "external" } ], "mass": 130585.0, "length": 1132, "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "Jak2", "organism": "Rat", "refseq_name": "tyrosine-protein kinase JAK2", "refseq_ac": [ { "id": "NP_113702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113702", "type": "external" } ], "gene_names_uniprotkb": "Jak2", "gene_names_refseq": "Jak2", "protein_names_uniprotkb": "Tyrosine-protein kinase JAK2; 2.7.10.2; JAK-2; Janus kinase 2", "protein_names_refseq": "JAK-2; Janus kinase 2 (a protein tyrosine kinase); tyrosine-protein kinase JAK2", "tax_id": 10116, "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); stroke (Disease Ontology:DOID:0051061); familial erythrocytosis 1 (Disease Ontology:DOID:0060652); isolated growth hormone deficiency type IA (Disease Ontology:DOID:0060873); thrombosis (Disease Ontology:DOID:0060903); myeloid neoplasm (Disease Ontology:DOID:0070004); Seckel syndrome 8 (Disease Ontology:DOID:0070009); colorectal carcinoma (Disease Ontology:DOID:0080199); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6 (Disease Ontology:DOID:0111519); stomach cancer (Disease Ontology:DOID:10534); portal hypertension (Disease Ontology:DOID:10762); esophageal carcinoma (Disease Ontology:DOID:1107); heart disease (Disease Ontology:DOID:114); Budd-Chiari syndrome (Disease Ontology:DOID:11512); primary biliary cholangitis (Disease Ontology:DOID:12236); leukemia (Disease Ontology:DOID:1240); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); disease of cellular proliferation (Disease Ontology:DOID:14566); limited scleroderma (Disease Ontology:DOID:1577); cancer (Disease Ontology:DOID:162); hyperuricemia (Disease Ontology:DOID:1920); atherosclerosis (Disease Ontology:DOID:1936); colon cancer (Disease Ontology:DOID:219); essential thrombocythemia (Disease Ontology:DOID:2224); myeloproliferative neoplasm (Disease Ontology:DOID:2226); thrombocytosis (Disease Ontology:DOID:2228); transient cerebral ischemia (Disease Ontology:DOID:224); colon adenocarcinoma (Disease Ontology:DOID:234); hematologic cancer (Disease Ontology:DOID:2531); Bloom syndrome (Disease Ontology:DOID:2717); liver cancer (Disease Ontology:DOID:3571); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); bacterial gastritis (Disease Ontology:DOID:4033); myelofibrosis (Disease Ontology:DOID:4971); liver cirrhosis (Disease Ontology:DOID:5082); retinal detachment (Disease Ontology:DOID:5327); Werner syndrome (Disease Ontology:DOID:5688); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); mitochondrial myopathy (Disease Ontology:DOID:699); ankylosing spondylitis (Disease Ontology:DOID:7147); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); polycythemia vera (Disease Ontology:DOID:8997); acute myeloid leukemia (Disease Ontology:DOID:9119); nasopharynx carcinoma (Disease Ontology:DOID:9261); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:24514); (R-RNO-1059683); (R-RNO-110056); (R-RNO-112411); (R-RNO-1170546); (R-RNO-1433557); (R-RNO-512988); (R-RNO-5673000); (R-RNO-5673001); (R-RNO-6785807); (R-RNO-6788467); (R-RNO-69231); (R-RNO-877300); (R-RNO-877312); (R-RNO-8854691); (R-RNO-8984722); (R-RNO-9006335); (R-RNO-9020591); (R-RNO-9020933); (R-RNO-9020956); (R-RNO-9027276); (R-RNO-9027284); (R-RNO-912526); (R-RNO-9674555); (R-RNO-9705462); (R-RNO-9732724); (R-RNO-982772); (R-RNO-983231); (R-RNO-9958825)", "pathway_count": 29, "publication_count": 10, "publication_id_list": "22673903;23533474;29393594;33731692;37641874;37759514;38154546;38306778;38796983;7607555", "class_list": "", "function": "Daucosterol regulates JAK2-STAT3 signaling pathway to promote megakaryocyte differentiation., [RefSeq, PubMed]; Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles promote the recovery of spinal cord injury by affecting the phenotype of astrocytes through the miR-21/JAK2/STAT3 pathway., [RefSeq, PubMed]; IFITM3 mediates inflammation induced myocardial injury through JAK2/STAT3 signaling pathway., [RefSeq, PubMed]; Non-membrane spanning protein tyrosine kinase that phosphorylates type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin receptor (MPL/TPOR); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Functionnally, plays a pivotal role in signal transduction and is involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. Mechanistically, following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin. Up-regulates the potassium voltage-gated channel activity of KCNA3. Binding of CNTF or the CLCF1/CLF heterodimer to CNTFR leads to IL6ST/gp130-LIFR dimerization followed by activation of JAK1 and JAK2 which in turns phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking proteins for STAT3. Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST)., [UniProtKB, UniProtKB]; PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction., [RefSeq, PubMed]; The Regulatory Effects of JAK2/STAT3 on Spermatogenesis and the Redox Keap1/Nrf2 Axis in an Animal Model of Testicular Ischemia Reperfusion Injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 51, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" } ], "go_molecular_function": "GO:0005143 interleukin-12 receptor binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0060399 positive regulation of growth hormone receptor signaling pathway;GO:0038043 interleukin-5-mediated signaling pathway;GO:0038156 interleukin-3-mediated signaling pathway;GO:0001774 microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q62689-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62703-1", "uniprot_id": [ { "id": "RCN2_RAT", "url": "https://www.uniprot.org/uniprot/Q62703", "type": "external" } ], "mass": 37433.0, "length": 320, "protein_name": "Reticulocalbin-2", "gene_name": "Rcn2", "organism": "Rat", "refseq_name": "reticulocalbin-2 precursor", "refseq_ac": [ { "id": "NP_058828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058828", "type": "external" } ], "gene_names_uniprotkb": "Rcn2; Erc55", "gene_names_refseq": "Rcn2", "protein_names_uniprotkb": "Reticulocalbin-2; Calcium-binding protein ERC-55; TCBP-49; Taipoxin-associated calcium-binding protein 49", "protein_names_refseq": "TCBP-49; calcium-binding protein ERC-55; reticulocalbin 2, EF-hand calcium binding domain; reticulocalbin-2 precursor; taipoxin-associated calcium-binding protein 49", "tax_id": 10116, "disease": "", "pathway": " (rno:29218)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7722520", "class_list": "", "function": "Not known. Binds calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6X5", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62703-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62718-1", "uniprot_id": [ { "id": "NTRI_RAT", "url": "https://www.uniprot.org/uniprot/Q62718", "type": "external" } ], "mass": 37998.0, "length": 344, "protein_name": "Neurotrimin", "gene_name": "Ntm", "organism": "Rat", "refseq_name": "neurotrimin isoform 8 precursor", "refseq_ac": [ { "id": "NP_059050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059050", "type": "external" } ], "gene_names_uniprotkb": "Ntm; Hnt; Nt", "gene_names_refseq": "GP65; Hnt; Ntm; RNU16845", "protein_names_uniprotkb": "Neurotrimin; GP65", "protein_names_refseq": "neurotrimin isoform 8 precursor; protein CEPU-1", "tax_id": 10116, "disease": "primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); uterine fibroid (Disease Ontology:DOID:13223); ovary epithelial cancer (Disease Ontology:DOID:2152); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:50864); (R-RNO-163125)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11984841;12373100;18729387;24090084;28801670;7891157", "class_list": "", "function": "Homophilic and heterophilic interactions between IgLON family members are likely to play a role in the specification of neuronal projections via growth promoting and inhibiting effects, respectively., [RefSeq, PubMed]; Neural cell adhesion molecule., [UniProtKB]; Neurotrimin and LSAMP were identified as ADAM10 substrates that are shed from the cell surface of dorsal root ganglion (DRGs) neurons. Overexpression of LSAMP and NTM suppresses outgrowth from DRG neurons. Furthermore, LSAMP loss of function decreases the outgrowth sensitivity to an ADAM10 inhibitor. Publication Status: Online-Only, [RefSeq, PubMed]; The spatio-temporal expression pattern of neurotrimin suggests that it plays a role in axonal fasciculation of specific cerebellar systems and may also be involved in the formation of excitatory synapses and their stabilization into adulthood., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 5, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 527, "biomarker_type": "", "glycan_count": 6, "disease_count": 5, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0010977 negative regulation of neuron projection development;GO:0032355 response to estradiol;GO:0060253 negative regulation of glial cell proliferation;GO:0051963 regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q62718-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62746-1", "uniprot_id": [ { "id": "SYT6_RAT", "url": "https://www.uniprot.org/uniprot/Q62746", "type": "external" } ], "mass": 57179.0, "length": 511, "protein_name": "Synaptotagmin-6", "gene_name": "Syt6", "organism": "Rat", "refseq_name": "synaptotagmin-6", "refseq_ac": [ { "id": "NP_071527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071527", "type": "external" } ], "gene_names_uniprotkb": "Syt6", "gene_names_refseq": "Syt6", "protein_names_uniprotkb": "Synaptotagmin-6; Synaptotagmin VI; SytVI", "protein_names_refseq": "synaptotagmin VI; synaptotagmin-6; sytVI", "tax_id": 10116, "disease": "", "pathway": " (rno:60565)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;7791877", "class_list": "", "function": "May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KLI6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0048306 calcium-dependent protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0097038 perinuclear endoplasmic reticulum", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0007340 acrosome reaction;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:0060478 acrosomal vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q62746-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62849-1", "uniprot_id": [ { "id": "PCSK7_RAT", "url": "https://www.uniprot.org/uniprot/Q62849", "type": "external" } ], "mass": 85599.0, "length": 783, "protein_name": "Proprotein convertase subtilisin/kexin type 7", "gene_name": "Pcsk7", "organism": "Rat", "refseq_name": "proprotein convertase subtilisin/kexin type 7 precursor", "refseq_ac": [ { "id": "NP_062119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062119", "type": "external" } ], "gene_names_uniprotkb": "Pcsk7; Pc7", "gene_names_refseq": "PC7; Pcsk7", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 7; 3.4.21.-; PC7; Prohormone convertase 7; Proprotein convertase 7; Subtilisin/kexin-like protease PC7; rPC7", "protein_names_refseq": "prohormone convertase 7; prohormone convertase PC7; proprotein convertase 7; proprotein convertase PC7; proprotein convertase subtilisin/kexin type 7 precursor; rPC7; subtilisin/kexin-like protease PC7", "tax_id": 10116, "disease": "autosomal recessive intellectual developmental disorder 67 (Disease Ontology:DOID:0081228); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29606); (R-RNO-9768727)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "21075846;23686857;8622945", "class_list": "", "function": "Overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner, [RefSeq, PubMed]; PC7 is distinct from other proprotein convertases in its zymogen activation, subcellular localization, and trafficking., [RefSeq, PubMed]; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q62849-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62850-1", "uniprot_id": [ { "id": "VR105_RAT", "url": "https://www.uniprot.org/uniprot/Q62850", "type": "external" } ], "mass": 35377.0, "length": 311, "protein_name": "Vomeronasal type-1 receptor 105", "gene_name": "Vom1r105", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vom1r105; Vmn1r51; Vnr1", "gene_names_refseq": "", "protein_names_uniprotkb": "Vomeronasal type-1 receptor 105; Pheromone receptor VN1; Vomeronasal receptor 1; Vomeronasal type-1 receptor 51; Vomeronasal type-1 receptor A1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:100312735)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7585937", "class_list": "", "function": "Putative pheromone receptor implicated in the regulation of social as well as reproductive behavior., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0016503 pheromone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q62850-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62866-1", "uniprot_id": [ { "id": "S19A1_RAT", "url": "https://www.uniprot.org/uniprot/Q62866", "type": "external" } ], "mass": 58108.0, "length": 512, "protein_name": "Reduced folate transporter", "gene_name": "Slc19a1", "organism": "Rat", "refseq_name": "reduced folate transporter", "refseq_ac": [ { "id": "NP_001030309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030309", "type": "external" } ], "gene_names_uniprotkb": "Slc19a1", "gene_names_refseq": "MTX-1; MTX1; Slc19a1", "protein_names_uniprotkb": "Reduced folate transporter; MTX-1; MTX1; Methotrexate carrier 1; Plasma membrane folate antiporter SLC19A1; RFC-1; RFC1; Reduced folate carrier 1; Solute carrier family 19 member 1", "protein_names_refseq": "RFC-1; RFC1; folate transporter 1; methotrexate carrier 1; methotrexate carrier 2; methotrexate carrier 5; methotrexate carrier 6; plasma membrane folate antiporter SLC19A1; reduced folate carrier 1; reduced folate transporter; solute carrier family 19 (folate transporter), member 1; solute carrier family 19 (sodium/hydrogen exchanger), member 1", "tax_id": 10116, "disease": "biotin-responsive basal ganglia disease (Disease Ontology:DOID:0050659); dextro-looped transposition of the great arteries (Disease Ontology:DOID:0060770); immunodeficiency 114 (Disease Ontology:DOID:0061080); malaria (Disease Ontology:DOID:12365); hematologic cancer (Disease Ontology:DOID:2531); abdominal aortic aneurysm (Disease Ontology:DOID:7693); chronic kidney disease (Disease Ontology:DOID:784); cleft lip (Disease Ontology:DOID:9296)", "pathway": " (rno:29723); (R-RNO-196757)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10827155;11600421;19243012;32521439;35850595", "class_list": "", "function": "Antiporter that mediates the import of reduced folates, driven by the export of organic anions (PubMed:11600421, PubMed:19243012). Also acts as an importer of immunoreactive cyclic dinucleotides, but with a lower transporter activity (By similarity). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (By similarity). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (By similarity). Also mediates the import of antifolate drug methotrexate (PubMed:10827155, PubMed:11600421). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]; Role of Slc19a1 and Tfr2 in liver transport of iron and folate: A rat model of folate/iron deficiency followed by supplementation., [RefSeq, PubMed]; Xanthones from securidaca inappendiculata antagonizes the anti-rheumatic effect of methotrexate by inhibiting reduced folate carrier 1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "D3ZQS7;Q9QUM8", "ec_number_list": [], "go_molecular_function": "GO:0015350 methotrexate transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015297 antiporter activity;GO:0005542 folic acid binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0051958 methotrexate transport;GO:0007565 female pregnancy;GO:0009636 response to toxic substance;GO:0015711 organic anion transport;GO:0006855 xenobiotic transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q62866-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q62923-1", "uniprot_id": [ { "id": "PNOC_RAT", "url": "https://www.uniprot.org/uniprot/Q62923", "type": "external" } ], "mass": 20479.0, "length": 181, "protein_name": "Prepronociceptin", "gene_name": "Pnoc", "organism": "Rat", "refseq_name": "prepronociceptin precursor", "refseq_ac": [ { "id": "NP_037139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037139", "type": "external" } ], "gene_names_uniprotkb": "Pnoc", "gene_names_refseq": "N23K; Npnc1; Pnoc", "protein_names_uniprotkb": "Prepronociceptin; ORL1 receptor agonist; Orphanin FQ; PPNOC", "protein_names_refseq": "Prepronociceptin (neuropeptide nociceptin) (N23K); neuropeptide nociceptin 1; nociceptin; orphanin FQ; prepronociceptin precursor", "tax_id": 10116, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); opioid abuse (Disease Ontology:DOID:11206); alcohol use disorder (Disease Ontology:DOID:1574); morphine dependence (Disease Ontology:DOID:2560); cocaine abuse (Disease Ontology:DOID:809); neonatal abstinence syndrome (Disease Ontology:DOID:9828)", "pathway": " (rno:25516); (R-RNO-375276); (R-RNO-418594)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "30302539;38316167;38338936;7566152;8710928;8710930", "class_list": "", "function": "An examination of the effects of nucleus accumbens core nociceptin on appetitive and consummatory motivation for food., [RefSeq, PubMed]; Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia., [UniProtKB, UniProtKB]; Both Pnoc and FoxP1 were expressed at high levels in the rostromedial tegmental nucleus and colocalized strongly with previously established RMTg markers., [RefSeq, PubMed]; Has potent analgesic activity., [UniProtKB, UniProtKB]; Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development., [UniProtKB, PubMed]; Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q64162", "ec_number_list": [], "go_molecular_function": "GO:0031628 opioid receptor binding;GO:0048018 receptor ligand activity;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043679 axon terminus", "go_biological_process": "GO:0098828 modulation of inhibitory postsynaptic potential;GO:0007218 neuropeptide signaling pathway;GO:0035094 response to nicotine;GO:0045471 response to ethanol;GO:0098815 modulation of excitatory postsynaptic potential", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q62923-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63089-1", "uniprot_id": [ { "id": "S22A1_RAT", "url": "https://www.uniprot.org/uniprot/Q63089", "type": "external" } ], "mass": 61541.0, "length": 556, "protein_name": "Solute carrier family 22 member 1", "gene_name": "Slc22a1", "organism": "Rat", "refseq_name": "solute carrier family 22 member 1", "refseq_ac": [ { "id": "NP_036829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036829", "type": "external" } ], "gene_names_uniprotkb": "Slc22a1; Oct1", "gene_names_refseq": "Oct1; Orct1; Roct1; Slc22a1", "protein_names_uniprotkb": "Solute carrier family 22 member 1; Organic cation transporter 1; rOCT1", "protein_names_refseq": "organic cation transporter 1; solute carrier family 22 (organic cation transporter), member 1; solute carrier family 22 member 1", "tax_id": 10116, "disease": "extrahepatic cholestasis (Disease Ontology:DOID:13619); intrahepatic cholestasis (Disease Ontology:DOID:1852); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021)", "pathway": " (rno:24904); (R-RNO-112311); (R-RNO-181430); (R-RNO-2161517); (R-RNO-442660); (R-RNO-549127); (R-RNO-9793528)", "pathway_count": 7, "publication_count": 33, "publication_id_list": "10570053;10864577;10997918;11083459;11408531;11502595;11758759;11792693;12395288;15122767;15640376;15662044;15817714;15829703;16142924;16272756;16581093;17553914;17567940;17616214;21454685;22673903;23280877;30409791;32961667;7990927;8955087;9195965;9405386;9703985;9776363;9808712;9830022", "class_list": "", "function": "Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10570053, PubMed:10864577, PubMed:10997918, PubMed:11408531, PubMed:11502595, PubMed:12395288, PubMed:15640376, PubMed:15662044, PubMed:16142924, PubMed:16272756, PubMed:16581093, PubMed:17567940, PubMed:7990927, PubMed:8955087). Functions as a pH- and Na(+)-independent, bidirectional transporter (PubMed:16142924, PubMed:8955087). Cation cellular uptake or release is driven by the electrochemical potential (i.e. membrane potential and concentration gradient) and substrate selectivity (PubMed:16142924, PubMed:17567940, PubMed:8955087, PubMed:9405386). Hydrophobicity is a major requirement for recognition in polyvalent substrates and inhibitors (By similarity). Primarily expressed in the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds from the blood by hepatic and renal clearance (PubMed:10997918, PubMed:7990927, PubMed:9703985). Most likely functions as an uptake carrier in enterocytes contributing to the intestinal excretion and elimination of organic cations from the systemic circulation (By similarity). Transports endogenous monoamines such as N-1-methylnicotinamide (NMN), guanidine, neurotransmitters dopamine, serotonin, noradrenaline, adrenaline and histamine, and quaternary ammonium compound such as choline (PubMed:10570053, PubMed:11408531, PubMed:11502595, PubMed:11758759, PubMed:15662044, PubMed:16581093, PubMed:17567940, PubMed:8955087, PubMed:9776363). Also transports natural polyamines such as spermidine, agmatine and putrescine at low affinity, but relatively high turnover (By similarity). Involved in the hepatic uptake of vitamin B1/thiamine, hence regulating hepatic lipid and energy metabolism (By similarity). Contributes to the influx and efflux of fatty acid carriers carnitines and acylcarnitines across the basolateral membrane of hepatocytes, from the liver to the systemic circulation and inversely and may be involved in regulating the systemic availability of hepatic acylcarnitines (By similarity). Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium (PubMed:15817714). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with lower efficiency (By similarity). Also capable of transporting non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (By similarity). May contribute to the transport of cationic compounds in testis across the blood-testis-barrier (Probable). Also mediates the uptake of xenobiotics tributylmethylammonium (TBuMA), quinidine, N-methyl-quinine (NMQ), N-methyl-quinidine (NMQD) N-(4,4-azo-n-pentyl)-quinuclidine (APQ), azidoprocainamide methoiodide (AMP), N-(4,4-azo-n-pentyl)-21-deoxyajmalinium (APDA) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (PubMed:10864577, PubMed:11408531, PubMed:12395288, PubMed:8955087)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction. Publication Status: Online-Only, [RefSeq, PubMed]; Functional isoform capable of transporting TEA., [UniProtKB, PubMed]; Protein and mRNA expression levels of Oat1, Oat3, Oct1, and Oct2 were significantly decreased in adenine-induced chronic renal failure rats., [RefSeq, PubMed]; The binding and transport of model substrate 1-methyl-4-phenylpyridinium(+) (MPP(+)) by cell-free-expressed fusion proteins of rOCT1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 42, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O35882;Q6AYW1", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0005334 norepinephrine:sodium symporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0015844 monoamine transport;GO:0015870 acetylcholine transport;GO:0072237 metanephric proximal tubule development;GO:0015695 organic cation transport", "synthesized_glycan_count": 0, "hit_score": 3.4, "record_id": "Q63089-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63262-1", "uniprot_id": [ { "id": "PO3F3_RAT", "url": "https://www.uniprot.org/uniprot/Q63262", "type": "external" } ], "mass": 50226.0, "length": 497, "protein_name": "POU domain, class 3, transcription factor 3", "gene_name": "Pou3f3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pou3f3; Brn-1; Brn1; Rhs2", "gene_names_refseq": "", "protein_names_uniprotkb": "POU domain, class 3, transcription factor 3; Brain-1; Brain-specific homeobox/POU domain protein 1; Brn-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:192109)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1348858;9405434;9632656", "class_list": "", "function": "Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0021869 forebrain ventricular zone progenitor cell division;GO:0071918 urea transmembrane transport;GO:0072218 metanephric ascending thin limb development;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63262-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63372-2", "uniprot_id": [ { "id": "NRX1A_RAT", "url": "https://www.uniprot.org/uniprot/Q63372", "type": "external" } ], "mass": 167923.0, "length": 1530, "protein_name": "Neurexin-1", "gene_name": "Nrxn1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Nrxn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurexin-1; Neurexin I-alpha; Neurexin-1-alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Pitt-Hopkins-like syndrome 2 (Disease Ontology:DOID:0111332); transient cerebral ischemia (Disease Ontology:DOID:224); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (rno:60391); (R-RNO-6794361)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10197529;11470830;12040031;1621094;18093522;20064387;20064388;25385611;38843836;7695896;8786425;9856994", "class_list": "", "function": "Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission (By similarity). Function is isoform-specific (By similarity). Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission (By similarity). Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions (By similarity). They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland (By similarity). They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery (By similarity). Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels (By similarity). Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2 (By similarity). In vitro, triggers the de novo formation of presynaptic structures (PubMed:20064387, PubMed:20064388). May be involved in specification of excitatory synapses (PubMed:20064387, PubMed:20064388). Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (PubMed:20064387, PubMed:20064388)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0004888 transmembrane signaling receptor activity;GO:0033130 acetylcholine receptor binding;GO:0048306 calcium-dependent protein binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0048787 presynaptic active zone membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0099054 presynapse assembly;GO:0097112 gamma-aminobutyric acid receptor clustering;GO:0090126 protein-containing complex assembly involved in synapse maturation;GO:0097091 synaptic vesicle clustering;GO:0097116 gephyrin clustering involved in postsynaptic density assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q63372-2", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63418-1", "uniprot_id": [ { "id": "PCDH3_RAT", "url": "https://www.uniprot.org/uniprot/Q63418", "type": "external" } ], "mass": 87474.0, "length": 797, "protein_name": "Protocadherin-3", "gene_name": "Pcdh3", "organism": "Rat", "refseq_name": "protocadherin-3 precursor", "refseq_ac": [ { "id": "NP_775122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775122", "type": "external" } ], "gene_names_uniprotkb": "Pcdh3", "gene_names_refseq": "Pcdh3; Pcdhb12; Pcdhb13; Pcdhb2l; Pcdhb2; pcdh-T4", "protein_names_uniprotkb": "Protocadherin-3", "protein_names_refseq": "Protocadherin-3, cadherin-related protein; protocadherin 3; protocadherin beta 13; protocadherin beta 2-like; protocadherin beta-6; protocadherin-3 precursor; protocadherin-T4", "tax_id": 10116, "disease": "leukodystrophy (Disease Ontology:DOID:10579)", "pathway": " (rno:25133)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8575755", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63418-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63449-1", "uniprot_id": [ { "id": "PRGR_RAT", "url": "https://www.uniprot.org/uniprot/Q63449", "type": "external" } ], "mass": 99408.0, "length": 923, "protein_name": "Progesterone receptor", "gene_name": "Pgr", "organism": "Rat", "refseq_name": "progesterone receptor", "refseq_ac": [ { "id": "NP_074038", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_074038", "type": "external" } ], "gene_names_uniprotkb": "Pgr; Nr3c3", "gene_names_refseq": "Pgr", "protein_names_uniprotkb": "Progesterone receptor; Nuclear receptor subfamily 3 group C member 3; PR", "protein_names_refseq": "PR; nuclear receptor subfamily 3 group C member 3; progesterone receptor", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); polycystic ovary syndrome (Disease Ontology:DOID:11612); hyperprolactinemia (Disease Ontology:DOID:12700); endometriosis (Disease Ontology:DOID:289); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25154); (R-RNO-3371497); (R-RNO-383280); (R-RNO-4090294); (R-RNO-9018519)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "17003284;1840636;25612677;25616002;30069875;31926947;34740365;8145766;8299566", "class_list": "", "function": "Bisphenol A (BPA) induces progesterone receptor expression in an estrogen receptor alpha-dependent manner in perinatal brain., [RefSeq, PubMed]; Individual and simultaneous activation of ERalpha and ERbeta have different effects on the levels and subcellular location of PRs in VMNvl neurons, [RefSeq, PubMed]; Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2., [UniProtKB, UniProtKB]; Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats. Publication Status: Online-Only, [RefSeq, PubMed]; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor (By similarity)., [UniProtKB, UniProtKB]; Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation., [UniProtKB, UniProtKB]; Virtually all PR cells co-expressed the calcium binding protein, calretinin, and the glycoprotein, reelin, both reliable markers for Cajal-Retzius neurons, a transient population of developmentally critical pioneer neurons that guide synaptogenesis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0050678 regulation of epithelial cell proliferation;GO:0060180 female mating behavior;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q63449-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63530-1", "uniprot_id": [ { "id": "PTER_RAT", "url": "https://www.uniprot.org/uniprot/Q63530", "type": "external" } ], "mass": 39145.0, "length": 349, "protein_name": "N-acetyltaurine hydrolase", "gene_name": "Pter", "organism": "Rat", "refseq_name": "N-acetyltaurine hydrolase", "refseq_ac": [ { "id": "NP_071560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071560", "type": "external" } ], "gene_names_uniprotkb": "Pter; Rpr-1", "gene_names_refseq": "Pter; Rpr-1; Rpr1", "protein_names_uniprotkb": "N-acetyltaurine hydrolase; 3.1.-.-; Phosphotriesterase-related protein; Resiniferotoxin-binding phosphotriesterase-related protein", "protein_names_refseq": "N-acetyltaurine hydrolase; parathion hydrolase-related protein; phosphotriesterase-related protein; resiniferatoxin-binding, phosphotriesterase-related protein; resiniferotoxin-binding phosphotriesterase-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:63852)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9237666", "class_list": "", "function": "N-acetyltaurine hydrolase that regulates feeding by catalyzing the hydrolysis of N-acetyltaurine into taurine and acetate (By similarity). N-acetyltaurine has anorexigenic and anti-obesity effects that are dependent on GFRAL receptor and GDF15 (By similarity). PTER also acts on other N-acetyl amino acids (Met, Ile, Leu, Val) and N-propionyltaurine, but at lower rates (By similarity). Binds resiniferotoxin, a vanilloid that desensitizes nociceptive neurons (PubMed:9237666)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AYY7", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.5.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.14", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0141215 N-acetyltaurine hydrolase activity;GO:0016788 hydrolase activity, acting on ester bonds", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0032098 regulation of appetite;GO:0019530 taurine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63530-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63570-1", "uniprot_id": [ { "id": "PRS6B_RAT", "url": "https://www.uniprot.org/uniprot/Q63570", "type": "external" } ], "mass": 47408.0, "length": 418, "protein_name": "26S proteasome regulatory subunit 6B", "gene_name": "Psmc4", "organism": "Rat", "refseq_name": "26S proteasome regulatory subunit 6B", "refseq_ac": [ { "id": "NP_476463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476463", "type": "external" } ], "gene_names_uniprotkb": "Psmc4; Tbp7", "gene_names_refseq": "Psmc4; Tbp7", "protein_names_uniprotkb": "26S proteasome regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; Proteasome 26S subunit ATPase 4; S6 ATPase; TBP-7; Tat-binding protein 7", "protein_names_refseq": "26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; 26S proteasome regulatory subunit 6B; S6 ATPase; TAT-binding protein 7; TBP-7; proteasome (prosome, macropain) 26S subunit, ATPase, 4; proteasome 26S ATPase subunit 4", "tax_id": 10116, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); hereditary spastic paraplegia (Disease Ontology:DOID:2476); amyotrophic lateral sclerosis (Disease Ontology:DOID:332)", "pathway": " (rno:117262); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 56, "publication_count": 2, "publication_id_list": "17292836;8607789", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0036402 proteasome-activating activity", "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0001824 blastocyst development;GO:2000311 regulation of AMPA receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q63570-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63647-1", "uniprot_id": [ { "id": "PNRC1_RAT", "url": "https://www.uniprot.org/uniprot/Q63647", "type": "external" } ], "mass": 32374.0, "length": 296, "protein_name": "Proline-rich nuclear receptor coactivator 1", "gene_name": "Pnrc1", "organism": "Rat", "refseq_name": "proline-rich nuclear receptor coactivator 1", "refseq_ac": [ { "id": "NP_775444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775444", "type": "external" } ], "gene_names_uniprotkb": "Pnrc1; Prol2", "gene_names_refseq": "Pnrc1; Prol2", "protein_names_uniprotkb": "Proline-rich nuclear receptor coactivator 1; Proline-rich protein 2", "protein_names_refseq": "proline rich 2; proline-rich nuclear receptor coactivator 1; proline-rich protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:286988)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8780705", "class_list": "", "function": "Nuclear receptor coactivator. May play a role in signal transduction (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63647-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63666-1", "uniprot_id": [ { "id": "VAMP1_RAT", "url": "https://www.uniprot.org/uniprot/Q63666", "type": "external" } ], "mass": 12797.0, "length": 118, "protein_name": "Vesicle-associated membrane protein 1", "gene_name": "Vamp1", "organism": "Rat", "refseq_name": "vesicle-associated membrane protein 1", "refseq_ac": [ { "id": "NP_037222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037222", "type": "external" } ], "gene_names_uniprotkb": "Vamp1; Syb1", "gene_names_refseq": "Syb1; Vamp1", "protein_names_uniprotkb": "Vesicle-associated membrane protein 1; Synaptobrevin-1; VAMP-1", "protein_names_refseq": "VAMP-1; synaptobrevin-1; vesicle-associated membrane protein 1", "tax_id": 10116, "disease": "spastic ataxia 1 (Disease Ontology:DOID:0050772); congenital myasthenic syndrome (Disease Ontology:DOID:3635)", "pathway": " (rno:25624)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12490191;1331807;2472388;25010769;26888187;27791016;28314111;28477408;8175689;8505288;9358054", "class_list": "", "function": "Differential sorting of the rat v-SNARE splice isoforms VAMP-1a and -1b, [RefSeq, PubMed]; Involved in the targeting and/or fusion of transport vesicles to their target membrane., [UniProtKB]; Our study uncovers the postsynaptic function of the SNAP25-VAMP1-syntaxin4 complex in mediating the constitutive exocytosis of NMDA receptors, suggesting that this SNARE complex is involved in excitatory synaptic transmission, [RefSeq, PubMed]; Residue 48 of VAMP1 varies frequently between M and I across seventeen closely related primate species, suggesting a potential selective pressure from members of BoNTs for resistance in vertebrates. Publication Status: Online-Only, [RefSeq, PubMed]; TNFalpha induces co-trafficking of TRPV1/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1/syntaxin1/SNAP-25 mediated fusion. Publication Status: Online-Only, [RefSeq, PubMed]; Together with previous studies, these data support a model whereby Munc18-1 acts as a template for SNARE complex assembly, and autoinhibition of synaptobrevin binding contributes to enabling regulation of neurotransmitter release by Munc13-1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6YSN3;O09025;Q56A22;Q8CH14", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0035493 SNARE complex assembly;GO:0006906 vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q63666-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63713-1", "uniprot_id": [ { "id": "RASA2_RAT", "url": "https://www.uniprot.org/uniprot/Q63713", "type": "external" } ], "mass": 96374.0, "length": 847, "protein_name": "Ras GTPase-activating protein 2", "gene_name": "Rasa2", "organism": "Rat", "refseq_name": "ras GTPase-activating protein 2", "refseq_ac": [ { "id": "NP_001099194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099194", "type": "external" } ], "gene_names_uniprotkb": "Rasa2", "gene_names_refseq": "GAP1M; Rasa2", "protein_names_uniprotkb": "Ras GTPase-activating protein 2; GAP1m", "protein_names_refseq": "ras GTPase-activating protein 2", "tax_id": 10116, "disease": "respiratory allergy (Disease Ontology:DOID:0060496); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); Noonan syndrome (Disease Ontology:DOID:3490); lung disease (Disease Ontology:DOID:850)", "pathway": " (rno:25597); (R-RNO-5658442)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7935405", "class_list": "", "function": "Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4) and phospholipids., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0035556 intracellular signal transduction;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63713-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63716-1", "uniprot_id": [ { "id": "PRDX1_RAT", "url": "https://www.uniprot.org/uniprot/Q63716", "type": "external" } ], "mass": 22109.0, "length": 199, "protein_name": "Peroxiredoxin-1", "gene_name": "Prdx1", "organism": "Rat", "refseq_name": "peroxiredoxin-1", "refseq_ac": [ { "id": "NP_476455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476455", "type": "external" } ], "gene_names_uniprotkb": "Prdx1; Tdpx2", "gene_names_refseq": "Hbp23; Prdx1", "protein_names_uniprotkb": "Peroxiredoxin-1; 1.11.1.24; HBP23; Heme-binding 23 kDa protein; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2; Thioredoxin-dependent peroxiredoxin 1", "protein_names_refseq": "heme-binding 23 kDa protein; peroxiredoxin-1; thioredoxin peroxidase 2; thioredoxin-dependent peroxide reductase 2; thioredoxin-dependent peroxiredoxin 1", "tax_id": 10116, "disease": "methylmalonic aciduria and homocystinuria type cblC (Disease Ontology:DOID:0050715)", "pathway": " (rno:117254); (R-RNO-3000471); (R-RNO-3299685); (R-RNO-5628897); (R-RNO-9818027)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10535922;17974571;27922677;29410271;32292063;33682513;7577926", "class_list": "", "function": "Pancreatic beta-cells use cytoplasmic Prdx1 as a primary defense mechanism against both ROS and RNS., [RefSeq, PubMed]; Prdx1 inhibited MAPK pathway induced cells apoptosis, and reactive oxygen species is the upstream regulator of hypoxia/reoxygenation induced apoptosis., [RefSeq, PubMed]; Silencing of peroxiredoxin 1 expression ameliorates ulcerative colitis in a rat model., [RefSeq, PubMed]; TLR4 silencing inhibits the peroxiredocin 1 -induced proliferation of vascular smooth muscle cells., [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0020037 heme binding;GO:0051920 peroxiredoxin activity;GO:0008379 thioredoxin peroxidase activity;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0008283 cell population proliferation;GO:0000302 response to reactive oxygen species;GO:0045454 cell redox homeostasis;GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q63716-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63797-1", "uniprot_id": [ { "id": "PSME1_RAT", "url": "https://www.uniprot.org/uniprot/Q63797", "type": "external" } ], "mass": 28577.0, "length": 249, "protein_name": "Proteasome activator complex subunit 1", "gene_name": "Psme1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Psme1", "gene_names_refseq": "", "protein_names_uniprotkb": "Proteasome activator complex subunit 1; 11S regulator complex subunit alpha; Activator of multicatalytic protease subunit 1; PA28alpha; PA28a; Proteasome activator 28 subunit alpha; REG-alpha", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:29630); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-9907900); (R-RNO-9912633)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "7789512", "class_list": "", "function": "Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000502 proteasome complex;GO:0008537 proteasome activator complex", "go_biological_process": "GO:2000045 regulation of G1/S transition of mitotic cell cycle;GO:0061136 regulation of proteasomal protein catabolic process;GO:0019884 antigen processing and presentation of exogenous antigen", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q63797-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63921-1", "uniprot_id": [ { "id": "PGH1_RAT", "url": "https://www.uniprot.org/uniprot/Q63921", "type": "external" } ], "mass": 69032.0, "length": 602, "protein_name": "Prostaglandin G/H synthase 1", "gene_name": "Ptgs1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ptgs1; Cox-1; Cox1", "gene_names_refseq": "", "protein_names_uniprotkb": "Prostaglandin G/H synthase 1; 1.14.99.1; COX-1; Cyclooxygenase-1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "salivary gland carcinoma (Disease Ontology:DOID:0050904); UV-sensitive syndrome (Disease Ontology:DOID:0060240); polycystic kidney disease (Disease Ontology:DOID:0080322); Cockayne syndrome A (Disease Ontology:DOID:0080907); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); hepatic encephalopathy (Disease Ontology:DOID:13413); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); cervix carcinoma (Disease Ontology:DOID:2893); Cockayne syndrome (Disease Ontology:DOID:2962); glioblastoma (Disease Ontology:DOID:3068); gliosarcoma (Disease Ontology:DOID:3071); bipolar disorder (Disease Ontology:DOID:3312); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); ulcerative colitis (Disease Ontology:DOID:8577)", "pathway": " (rno:24693); (R-RNO-140180); (R-RNO-2162123)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10966456;24605250;29393594;7864644;8274023", "class_list": "", "function": "Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q62731;Q63684", "ec_number_list": [ { "id": "1.14.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.1", "type": "external" } ], "go_molecular_function": "GO:0004666 prostaglandin-endoperoxide synthase activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0007612 learning;GO:0007613 memory;GO:0042127 regulation of cell population proliferation;GO:0045987 positive regulation of smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q63921-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641W3-1", "uniprot_id": [ { "id": "NUFP1_RAT", "url": "https://www.uniprot.org/uniprot/Q641W3", "type": "external" } ], "mass": 55090.0, "length": 486, "protein_name": "FMR1-interacting protein NUFIP1", "gene_name": "Nufip1", "organism": "Rat", "refseq_name": "FMR1-interacting protein NUFIP1", "refseq_ac": [ { "id": "NP_001007759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007759", "type": "external" } ], "gene_names_uniprotkb": "Nufip1", "gene_names_refseq": "Nufip1", "protein_names_uniprotkb": "FMR1-interacting protein NUFIP1; Nuclear FMRP-interacting protein 1", "protein_names_refseq": "FMR1-interacting protein NUFIP1; NUFIP1, FMR1 interacting protein 1; nuclear FMRP-interacting protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:364430)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Binds RNA., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0008023 transcription elongation factor complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000492 box C/D snoRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q641W3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Y2-1", "uniprot_id": [ { "id": "NDUS2_RAT", "url": "https://www.uniprot.org/uniprot/Q641Y2", "type": "external" } ], "mass": 52562.0, "length": 463, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial", "gene_name": "Ndufs2", "organism": "Rat", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001011907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011907", "type": "external" } ], "gene_names_uniprotkb": "Ndufs2", "gene_names_refseq": "Ndufs2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; 7.1.1.2; CI-49kD; Complex I-49kD; NADH-ubiquinone oxidoreductase 49 kDa subunit", "protein_names_refseq": "CI-49kD; NADH dehydrogenase (ubiquinone) Fe-S protein 2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial precursor; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH-ubiquinone oxidoreductase 49 kDa subunit; complex I-49kD", "tax_id": 10116, "disease": "mitochondrial complex I deficiency (Disease Ontology:DOID:0060536); nuclear type mitochondrial complex I deficiency 6 (Disease Ontology:DOID:0112066); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); alcohol use disorder (Disease Ontology:DOID:1574); multiple sclerosis (Disease Ontology:DOID:2377); Leigh disease (Disease Ontology:DOID:3652); inherited metabolic disorder (Disease Ontology:DOID:655)", "pathway": " (rno:289218); (R-RNO-611105); (R-RNO-6799198)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "18683930;19343716;26446791;27213235;30922174;34502162;38843836", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30922174). Essential for the catalytic activity of complex I (PubMed:30922174). Essential for the assembly of complex I (By similarity). Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed:30922174). Plays an important role in carotid body sensing of hypoxia (By similarity). Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" } ], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0031625 ubiquitin protein ligase binding;GO:0051287 NAD binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042063 gliogenesis;GO:0022008 neurogenesis;GO:0061351 neural precursor cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q641Y2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q641Y7-1", "uniprot_id": [ { "id": "NUD18_RAT", "url": "https://www.uniprot.org/uniprot/Q641Y7", "type": "external" } ], "mass": 35647.0, "length": 323, "protein_name": "8-oxo-dGDP phosphatase NUDT18", "gene_name": "Nudt18", "organism": "Rat", "refseq_name": "8-oxo-dGDP phosphatase NUDT18", "refseq_ac": [ { "id": "NP_001094202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094202", "type": "external" } ], "gene_names_uniprotkb": "Nudt18", "gene_names_refseq": "Nudt18; RGD1311802", "protein_names_uniprotkb": "8-oxo-dGDP phosphatase NUDT18; 2-hydroxy-dADP phosphatase; 3.6.1.58; 3.6.1.68; 3.6.1.76; 7,8-dihydro-8-oxoguanine phosphatase; Nucleoside diphosphate-linked moiety X motif 18; Nudix motif 18", "protein_names_refseq": "2-hydroxy-dADP phosphatase; 7,8-dihydro-8-oxoguanine phosphatase; 8-oxo-dGDP phosphatase NUDT18; mutT homolog 3; nucleoside diphosphate-linked moiety X motif 18; nudix (nucleoside diphosphate linked moiety X)-type motif 18; nudix motif 18", "tax_id": 10116, "disease": "", "pathway": " (rno:361068); (R-RNO-2393930)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Also hydrolyzes 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. In vitro, it catalyzes the hydrolysis of isoprene pyrophosphates, including (2E)-geranyl diphosphate, isopentenyl diphosphate, (2E,6E)-farnesyl diphosphate and dimethylallyl diphosphate. It may therefore play a role in the control of cellular levels of these metabolites that are essential for multiple cellular processes, including isoprenoids synthesis and protein isoprenylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KM80", "ec_number_list": [ { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" }, { "id": "3.6.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76", "type": "external" }, { "id": "3.6.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.58", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.13", "type": "external" }, { "id": "2.7.7.96", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.96", "type": "external" } ], "go_molecular_function": "GO:0044715 8-oxo-dGDP phosphatase activity;GO:0044716 8-oxo-GDP phosphatase activity;GO:0044717 8-hydroxy-dADP phosphatase activity;GO:0046872 metal ion binding;GO:0106405 isoprenoid diphosphate phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0046057 dADP catabolic process;GO:0046067 dGDP catabolic process;GO:0046712 GDP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q641Y7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q642A6-1", "uniprot_id": [ { "id": "VWA1_RAT", "url": "https://www.uniprot.org/uniprot/Q642A6", "type": "external" } ], "mass": 44832.0, "length": 415, "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "Vwa1", "organism": "Rat", "refseq_name": "von Willebrand factor A domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001013960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013960", "type": "external" } ], "gene_names_uniprotkb": "Vwa1", "gene_names_refseq": "RGD1311476; Vwa1", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 1", "protein_names_refseq": "von Willebrand factor A domain-containing protein 1 precursor; von Willebrand factor A domain-containing protein 1", "tax_id": 10116, "disease": "autosomal recessive distal hereditary motor neuronopathy 7 (Disease Ontology:DOID:0081426); motor neuron disease (Disease Ontology:DOID:231)", "pathway": " (rno:298683); (R-RNO-381426); (R-RNO-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Promotes matrix assembly (By similarity). Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050436 microfibril binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005614 interstitial matrix", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0051260 protein homooligomerization;GO:0048266 behavioral response to pain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q642A6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64303-1", "uniprot_id": [ { "id": "PAK2_RAT", "url": "https://www.uniprot.org/uniprot/Q64303", "type": "external" } ], "mass": 57960.0, "length": 524, "protein_name": "Serine/threonine-protein kinase PAK 2", "gene_name": "Pak2", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase PAK 2", "refseq_ac": [ { "id": "NP_001380632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380632", "type": "external" } ], "gene_names_uniprotkb": "Pak2", "gene_names_refseq": "PAK-2; Pak2; gamma-PAK", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK 2; 2.7.11.1; Gamma-PAK; PAK-2; p21-activated kinase 2", "protein_names_refseq": "p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; serine/threonine-protein kinase PAK 2-like; serine/threonine-protein kinase PAK 2", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); ductal carcinoma in situ (Disease Ontology:DOID:0060074); ureteral obstruction (Disease Ontology:DOID:5199)", "pathway": " (rno:29432); (R-RNO-202433); (R-RNO-2871796); (R-RNO-389359); (R-RNO-3928664); (R-RNO-399954); (R-RNO-4420097); (R-RNO-445355); (R-RNO-5218920); (R-RNO-5621575); (R-RNO-5627123); (R-RNO-5687128); (R-RNO-9013149); (R-RNO-9013404); (R-RNO-9013406); (R-RNO-9013407); (R-RNO-9013408); (R-RNO-9013420); (R-RNO-9013423); (R-RNO-9013424)", "pathway_count": 20, "publication_count": 8, "publication_id_list": "16396499;16641100;22673903;25979836;26912410;28408623;30620686;7592896", "class_list": "", "function": "PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases., [RefSeq, PubMed]; PAK2 regulates cell death pathways in pancreatic acinar cells promoting cell death ., [RefSeq, PubMed]; Pak2 promotes a protective endoplasmic reticulum stress response, protecting the heart from disease., [RefSeq, PubMed]; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Phosphorylates CASP7, thereby preventing its activity. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity)., [UniProtKB, UniProtKB]; These results show that PAK2 is important in signaling cascades activated by numerous pancreatic stimuli which mediate their various physiological/pathophysiological responses, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QYU0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "1.16.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0150105 protein localization to cell-cell junction;GO:0006468 protein phosphorylation;GO:0016477 cell migration;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q64303-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q64305-1", "uniprot_id": [ { "id": "PTF1A_RAT", "url": "https://www.uniprot.org/uniprot/Q64305", "type": "external" } ], "mass": 35305.0, "length": 326, "protein_name": "Pancreas transcription factor 1 subunit alpha", "gene_name": "Ptf1a", "organism": "Rat", "refseq_name": "pancreas transcription factor 1 subunit alpha", "refseq_ac": [ { "id": "NP_446416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446416", "type": "external" } ], "gene_names_uniprotkb": "Ptf1a; Ptf1p48", "gene_names_refseq": "Ptf1a", "protein_names_uniprotkb": "Pancreas transcription factor 1 subunit alpha; PTF1-p48; Pancreas-specific transcription factor 1a; bHLH transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1", "protein_names_refseq": "PTF1-p48; bHLH transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; pancreas specific transcription factor, 1a; pancreas transcription factor 1 subunit alpha", "tax_id": 10116, "disease": "pancreatic agenesis 2 (Disease Ontology:DOID:0060988)", "pathway": " (rno:117034)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10768861;8703005;8861960", "class_list": "", "function": "Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0060042 retina morphogenesis in camera-type eye;GO:0061074 regulation of neural retina development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q64305-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H19-1", "uniprot_id": [ { "id": "SRFB1_RAT", "url": "https://www.uniprot.org/uniprot/Q66H19", "type": "external" } ], "mass": 49195.0, "length": 442, "protein_name": "Serum response factor-binding protein 1", "gene_name": "Srfbp1", "organism": "Rat", "refseq_name": "serum response factor-binding protein 1", "refseq_ac": [ { "id": "NP_001005536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005536", "type": "external" } ], "gene_names_uniprotkb": "Srfbp1", "gene_names_refseq": "Srfbp1; p49/STRAP", "protein_names_uniprotkb": "Serum response factor-binding protein 1; SRF-dependent transcription regulation-associated protein; p49/STRAP", "protein_names_refseq": "SRF-dependent transcription regulation-associated protein; serum response factor-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:291469)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;29393594", "class_list": "", "function": "May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0030686 90S preribosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q66H19-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H20-1", "uniprot_id": [ { "id": "PTBP2_RAT", "url": "https://www.uniprot.org/uniprot/Q66H20", "type": "external" } ], "mass": 57489.0, "length": 531, "protein_name": "Polypyrimidine tract-binding protein 2", "gene_name": "Ptbp2", "organism": "Rat", "refseq_name": "polypyrimidine tract-binding protein 2", "refseq_ac": [ { "id": "NP_001005555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005555", "type": "external" } ], "gene_names_uniprotkb": "Ptbp2; Nptb; Ptblp", "gene_names_refseq": "PTBLP-L; PTBLP-S; PTBLP; Ptb2; Ptbp2", "protein_names_uniprotkb": "Polypyrimidine tract-binding protein 2; Neural polypyrimidine tract-binding protein; PTB-like protein", "protein_names_refseq": "PTB-like protein; neural polypyrimidine tract-binding protein; polypyrimidine tract-binding protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:310820)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11694331;14667811;21139978;22673903", "class_list": "", "function": "RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation., [UniProtKB, UniProtKB, UniProtKB]; The predominant expression of REST4, HuB/C/D and nPTB in post-mitotic fiber cells, together with miR-124 expression in vertebrate lenses, was shown. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q78ZE9;Q7TNW8", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030426 growth cone;GO:0043025 neuronal cell body;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0021510 spinal cord development;GO:0043484 regulation of RNA splicing;GO:0021549 cerebellum development;GO:0006376 mRNA splice site recognition;GO:0033119 negative regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66H20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H68-1", "uniprot_id": [ { "id": "RBM47_RAT", "url": "https://www.uniprot.org/uniprot/Q66H68", "type": "external" } ], "mass": 64094.0, "length": 590, "protein_name": "RNA-binding protein 47", "gene_name": "Rbm47", "organism": "Rat", "refseq_name": "RNA-binding protein 47", "refseq_ac": [ { "id": "NP_001005882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005882", "type": "external" } ], "gene_names_uniprotkb": "Rbm47", "gene_names_refseq": "RGD1359713; Rbm47", "protein_names_uniprotkb": "RNA-binding protein 47; RNA-binding motif protein 47", "protein_names_refseq": "RNA-binding protein 47; hypothetical RNA binding protein RGD1359713", "tax_id": 10116, "disease": "", "pathway": " (rno:305340)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing. Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules. Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10. Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons regulating their exclusion and inclusion into mRNAs (By similarity). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019899 enzyme binding;GO:0003730 mRNA 3'-UTR binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030895 apolipoprotein B mRNA editing enzyme complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0016554 cytidine to uridine editing;GO:0008380 RNA splicing;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:0002244 hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H68-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66H78-1", "uniprot_id": [ { "id": "PXYP1_RAT", "url": "https://www.uniprot.org/uniprot/Q66H78", "type": "external" } ], "mass": 54958.0, "length": 480, "protein_name": "2-phosphoxylose phosphatase 1", "gene_name": "Pxylp1", "organism": "Rat", "refseq_name": "2-phosphoxylose phosphatase 1", "refseq_ac": [ { "id": "NP_001007711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007711", "type": "external" } ], "gene_names_uniprotkb": "Pxylp1; Acpl2", "gene_names_refseq": "Acpl2; Pxylp1", "protein_names_uniprotkb": "2-phosphoxylose phosphatase 1; 3.1.3.-; Acid phosphatase-like protein 2", "protein_names_refseq": "2-phosphoxylose phosphatase 1; acid phosphatase-like 2; acid phosphatase-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:315939); (R-RNO-1971475)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0016791 phosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66H78-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HB5-1", "uniprot_id": [ { "id": "RS10B_RAT", "url": "https://www.uniprot.org/uniprot/Q66HB5", "type": "external" } ], "mass": 101587.0, "length": 876, "protein_name": "Radial spoke head 10 homolog B", "gene_name": "Rsph10b", "organism": "Rat", "refseq_name": "radial spoke head 10 homolog B", "refseq_ac": [ { "id": "NP_001013889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013889", "type": "external" } ], "gene_names_uniprotkb": "Rsph10b", "gene_names_refseq": "RGD1311893; Rsph10b", "protein_names_uniprotkb": "Radial spoke head 10 homolog B", "protein_names_refseq": "radial spoke head 10 homolog B", "tax_id": 10116, "disease": "", "pathway": " (rno:288478)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May function as part of the axonemal radial spoke complex 3 (RS3). Radial spoke complexes are important for ciliary motility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0097729 9+2 motile cilium;GO:0031514 motile cilium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HB5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HC4-1", "uniprot_id": [ { "id": "PHOP2_RAT", "url": "https://www.uniprot.org/uniprot/Q66HC4", "type": "external" } ], "mass": 27627.0, "length": 241, "protein_name": "Pyridoxal phosphate phosphatase PHOSPHO2", "gene_name": "Phospho2", "organism": "Rat", "refseq_name": "pyridoxal phosphate phosphatase PHOSPHO2", "refseq_ac": [ { "id": "NP_001007643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007643", "type": "external" } ], "gene_names_uniprotkb": "Phospho2", "gene_names_refseq": "Phospho2", "protein_names_uniprotkb": "Pyridoxal phosphate phosphatase PHOSPHO2; 3.1.3.74", "protein_names_refseq": "pyridoxal phosphate phosphatase PHOSPHO2", "tax_id": 10116, "disease": "", "pathway": " (rno:295663)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0033883 pyridoxal phosphatase activity;GO:0046872 metal ion binding;GO:0016791 phosphatase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HC4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HE1-1", "uniprot_id": [ { "id": "PNRC2_RAT", "url": "https://www.uniprot.org/uniprot/Q66HE1", "type": "external" } ], "mass": 14881.0, "length": 134, "protein_name": "Proline-rich nuclear receptor coactivator 2", "gene_name": "Pnrc2", "organism": "Rat", "refseq_name": "proline-rich nuclear receptor coactivator 2", "refseq_ac": [ { "id": "NP_001096830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096830", "type": "external" } ], "gene_names_uniprotkb": "Pnrc2", "gene_names_refseq": "Pnrc2", "protein_names_uniprotkb": "Proline-rich nuclear receptor coactivator 2", "protein_names_refseq": "proline-rich nuclear receptor coactivator 2", "tax_id": 10116, "disease": "", "pathway": " (rno:100125373); (R-RNO-975957)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000932 P-body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HE1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HE5-1", "uniprot_id": [ { "id": "NUAK2_RAT", "url": "https://www.uniprot.org/uniprot/Q66HE5", "type": "external" } ], "mass": 69953.0, "length": 630, "protein_name": "NUAK family SNF1-like kinase 2", "gene_name": "Nuak2", "organism": "Rat", "refseq_name": "NUAK family SNF1-like kinase 2", "refseq_ac": [ { "id": "NP_001007618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007618", "type": "external" } ], "gene_names_uniprotkb": "Nuak2", "gene_names_refseq": "1200013b22rik; Nuak2; Snark; UV126", "protein_names_uniprotkb": "NUAK family SNF1-like kinase 2; 2.7.11.1; SNARK; SNF1/AMP kinase-related kinase", "protein_names_refseq": "NUAK family SNF1-like kinase 2; NUAK family, SNF1-like kinase, 2; SNF1/AMP kinase-related kinase; SNF1/AMP-activated protein kinase", "tax_id": 10116, "disease": "anencephaly (Disease Ontology:DOID:0060668)", "pathway": " (rno:289419)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11284715;15893879;29393594", "class_list": "", "function": "SNARK (SNF1/AMP-activated protein kinase) activity is regulated by a broad range of cellular stresses in a cell-type-specific manner., [RefSeq, PubMed]; Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0016607 nuclear speck", "go_biological_process": "GO:0035330 regulation of hippo signaling;GO:0006468 protein phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q66HE5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HG5-1", "uniprot_id": [ { "id": "TM9S2_RAT", "url": "https://www.uniprot.org/uniprot/Q66HG5", "type": "external" } ], "mass": 75586.0, "length": 663, "protein_name": "Transmembrane 9 superfamily member 2", "gene_name": "Tm9sf2", "organism": "Rat", "refseq_name": "transmembrane 9 superfamily member 2 precursor", "refseq_ac": [ { "id": "NP_001005554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005554", "type": "external" } ], "gene_names_uniprotkb": "Tm9sf2", "gene_names_refseq": "Tm9sf2", "protein_names_uniprotkb": "Transmembrane 9 superfamily member 2", "protein_names_refseq": "transmembrane 9 superfamily member 2 precursor", "tax_id": 10116, "disease": "acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:306197)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the intracellular compartments, may function as a channel or small molecule transporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0005815 microtubule organizing center;GO:0010008 endosome membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0006672 ceramide metabolic process;GO:0072657 protein localization to membrane;GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q66HG5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HP6-1", "uniprot_id": [ { "id": "SPAT2_RAT", "url": "https://www.uniprot.org/uniprot/Q66HP6", "type": "external" } ], "mass": 57481.0, "length": 511, "protein_name": "Spermatogenesis-associated protein 2", "gene_name": "Spata2", "organism": "Rat", "refseq_name": "spermatogenesis-associated protein 2", "refseq_ac": [ { "id": "NP_446127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446127", "type": "external" } ], "gene_names_uniprotkb": "Spata2; Pd1", "gene_names_refseq": "Spata2", "protein_names_uniprotkb": "Spermatogenesis-associated protein 2", "protein_names_refseq": "spermatogenesis-associated protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:114210); (R-RNO-5357786); (R-RNO-5357905); (R-RNO-5357956)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "11079456;11322771;29393594;34075523", "class_list": "", "function": "Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (By similarity). Controls the kinase activity of RIPK1 and TNF-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Spata2 Knockdown Exacerbates Brain Inflammation via NF-kappaB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1LNA7;Q91XS7", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:1990381 ubiquitin-specific protease binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0070536 protein K63-linked deubiquitination;GO:0050727 regulation of inflammatory response;GO:0072520 seminiferous tubule development;GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q66HP6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66HR9-1", "uniprot_id": [ { "id": "SAXO4_RAT", "url": "https://www.uniprot.org/uniprot/Q66HR9", "type": "external" } ], "mass": 47597.0, "length": 425, "protein_name": "Stabilizer of axonemal microtubules 4", "gene_name": "Saxo4", "organism": "Rat", "refseq_name": "stabilizer of axonemal microtubules 4", "refseq_ac": [ { "id": "NP_665729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665729", "type": "external" } ], "gene_names_uniprotkb": "Saxo4; Iiig9; Ppp1r32", "gene_names_refseq": "Iiig9; Ppp1r32; Saxo4", "protein_names_uniprotkb": "Stabilizer of axonemal microtubules 4; Protein IIIG9; Protein phosphatase 1 regulatory subunit 32", "protein_names_refseq": "protein phosphatase 1, regulatory subunit 32; stabilizer of axonemal microtubules 4; uncharacterized protein C11orf66 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:252958)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15018803;28194645;34535732", "class_list": "", "function": "IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment. Publication Status: Online-Only, [RefSeq, PubMed]; IIIG9 is localized in the cilia of adult ependymal cells and that its expression is correlated with the process of ependymal differentiation and with the maturation of radial glia., [RefSeq, PubMed]; IIIG9 mRNA is expressed along brain ventricles, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q91XJ3;Q91XJ4", "ec_number_list": [], "go_molecular_function": "GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005929 cilium;GO:0036126 sperm flagellum;GO:0036064 ciliary basal body;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q66HR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q675A5-1", "uniprot_id": [ { "id": "PAG15_RAT", "url": "https://www.uniprot.org/uniprot/Q675A5", "type": "external" } ], "mass": 47391.0, "length": 413, "protein_name": "Lysosomal phospholipase A and acyltransferase", "gene_name": "Pla2g15", "organism": "Rat", "refseq_name": "lysosomal phospholipase A and acyltransferase precursor", "refseq_ac": [ { "id": "NP_001004277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004277", "type": "external" } ], "gene_names_uniprotkb": "Pla2g15; Lypla3", "gene_names_refseq": "1-O-acylceramidesynthase; ACS; LLPL; LPLA2; Lypla3; Pla2g15", "protein_names_uniprotkb": "Lysosomal phospholipase A and acyltransferase; 1-O-acylceramide synthase; 2.3.1.-; 3.1.1.32; 3.1.1.4; 3.1.1.5; ACS; LCAT-like lysophospholipase; LLPL; LPLA2; Lysophospholipase 3; Lysosomal phospholipase A2; Phospholipase A2 group XV", "protein_names_refseq": "1-O-acylceramide synthase; LCAT-like lysophospholipase; group XV phospholipase A2; lysophospholipase 3; lysosomal phospholipase A and acyltransferase precursor; lysosomal phospholipase A and acyltransferase; lysosomal phospholipase A2", "tax_id": 10116, "disease": "", "pathway": " (rno:361401); (R-RNO-1483115)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15294901;29393594", "class_list": "", "function": "Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:15294901). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:15294901). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines. Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines, phosphatidylethanolamines, and phosphatidylglycerols (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide. Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress (By similarity). Required for normal phospholipid degradation in alveolar macrophages with potential implications in the clearance of pulmonary surfactant, which is mainly composed of dipalmitoylphosphatidylcholine (1,2-dihexadecanoyl-sn-glycero-3-phosphocholine) (PubMed:15294901). Involved in the first step of bis(monoacylglycero)phosphate (BMP) de novo synthesis from phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (By similarity). BMP is an important player in cargo sorting and degradation, regulation of cellular cholesterol levels and intercellular communication. At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; LPLA2 may be a major enzyme of pulmonary surfactant phospholipid degradation by alveolar macrophages, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0016411 acylglycerol O-acyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0046338 phosphatidylethanolamine catabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0006631 fatty acid metabolic process;GO:0006672 ceramide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q675A5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q675B7-1", "uniprot_id": [ { "id": "TR136_RAT", "url": "https://www.uniprot.org/uniprot/Q675B7", "type": "external" } ], "mass": 37358.0, "length": 330, "protein_name": "Taste receptor type 2 member 136", "gene_name": "Tas2r136", "organism": "Rat", "refseq_name": "taste receptor type 2 member 136", "refseq_ac": [ { "id": "NP_001160150", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160150", "type": "external" } ], "gene_names_uniprotkb": "Tas2r136; Tas2r40", "gene_names_refseq": "Tas2r136", "protein_names_uniprotkb": "Taste receptor type 2 member 136; T2R136; T2R40; Taste receptor type 2 member 40", "protein_names_refseq": "T2R136; T2R40; taste receptor type 2 member 136; taste receptor type 2 member 40", "tax_id": 10116, "disease": "", "pathway": " (rno:100310876); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q675B7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q675B8-1", "uniprot_id": [ { "id": "TR117_RAT", "url": "https://www.uniprot.org/uniprot/Q675B8", "type": "external" } ], "mass": 37090.0, "length": 318, "protein_name": "Taste receptor type 2 member 117", "gene_name": "Tas2r117", "organism": "Rat", "refseq_name": "taste receptor type 2 member 117", "refseq_ac": [ { "id": "NP_001160154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160154", "type": "external" } ], "gene_names_uniprotkb": "Tas2r117; T2r39", "gene_names_refseq": "Tas2r117", "protein_names_uniprotkb": "Taste receptor type 2 member 117; T2R117; T2R39; Taste receptor type 2 member 39", "protein_names_refseq": "T2R117; T2R39; taste receptor type 2 member 117; taste receptor type 2 member 39", "tax_id": 10116, "disease": "", "pathway": " (rno:100310880)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q675B8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q675B9-1", "uniprot_id": [ { "id": "TR109_RAT", "url": "https://www.uniprot.org/uniprot/Q675B9", "type": "external" } ], "mass": 37481.0, "length": 320, "protein_name": "Taste receptor type 2 member 109", "gene_name": "Tas2r109", "organism": "Rat", "refseq_name": "taste receptor type 2 member 109", "refseq_ac": [ { "id": "NP_001074408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074408", "type": "external" } ], "gene_names_uniprotkb": "Tas2r109; Tas2r38", "gene_names_refseq": "Tas2r109", "protein_names_uniprotkb": "Taste receptor type 2 member 109; T2R109; T2R38; Taste receptor type 2 member 38", "protein_names_refseq": "T2R109; putative taste receptor T2R38; taste receptor type 2 member 109; taste receptor type 2 member 38", "tax_id": 10116, "disease": "", "pathway": " (rno:690572)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q675B9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q675C0-1", "uniprot_id": [ { "id": "TR102_RAT", "url": "https://www.uniprot.org/uniprot/Q675C0", "type": "external" } ], "mass": 37656.0, "length": 327, "protein_name": "Taste receptor type 2 member 102", "gene_name": "Tas2r102", "organism": "Rat", "refseq_name": "taste receptor type 2 member 102", "refseq_ac": [ { "id": "NP_001028836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028836", "type": "external" } ], "gene_names_uniprotkb": "Tas2r102; Tas2r37", "gene_names_refseq": "T2R102; T2R37; Tas2r102", "protein_names_uniprotkb": "Taste receptor type 2 member 102; T2R102; T2R37; Taste receptor type 2 member 37", "protein_names_refseq": "taste receptor type 2 member 102; taste receptor type 2 member 37", "tax_id": 10116, "disease": "", "pathway": " (rno:500347)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q675C0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ER8-1", "uniprot_id": [ { "id": "TR116_RAT", "url": "https://www.uniprot.org/uniprot/Q67ER8", "type": "external" } ], "mass": 37020.0, "length": 324, "protein_name": "Taste receptor type 2 member 116", "gene_name": "Tas2r116", "organism": "Rat", "refseq_name": "taste receptor type 2 member 116", "refseq_ac": [ { "id": "NP_001160151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160151", "type": "external" } ], "gene_names_uniprotkb": "Tas2r116; T2r33", "gene_names_refseq": "Tas2r116", "protein_names_uniprotkb": "Taste receptor type 2 member 116; T2R116; T2R33; Taste receptor type 2 member 33", "protein_names_refseq": "T2R116; T2R33; taste receptor type 2 member 116; taste receptor type 2 member 33", "tax_id": 10116, "disease": "", "pathway": " (rno:100310877)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ER8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ES1-1", "uniprot_id": [ { "id": "TR113_RAT", "url": "https://www.uniprot.org/uniprot/Q67ES1", "type": "external" } ], "mass": 36021.0, "length": 309, "protein_name": "Taste receptor type 2 member 113", "gene_name": "Tas2r113", "organism": "Rat", "refseq_name": "taste receptor type 2 member 113", "refseq_ac": [ { "id": "NP_001160161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160161", "type": "external" } ], "gene_names_uniprotkb": "Tas2r113; Tas2r30", "gene_names_refseq": "T2R30; Tas2r113", "protein_names_uniprotkb": "Taste receptor type 2 member 113; T2R113; T2R30; Taste receptor type 2 member 30", "protein_names_refseq": "T2R113; taste receptor type 2 member 113; taste receptor type 2 member 30", "tax_id": 10116, "disease": "", "pathway": " (rno:100310885)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ES1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ES3-1", "uniprot_id": [ { "id": "TR143_RAT", "url": "https://www.uniprot.org/uniprot/Q67ES3", "type": "external" } ], "mass": 34111.0, "length": 294, "protein_name": "Taste receptor type 2 member 143", "gene_name": "Tas2r143", "organism": "Rat", "refseq_name": "taste receptor type 2 member 143", "refseq_ac": [ { "id": "NP_001020232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020232", "type": "external" } ], "gene_names_uniprotkb": "Tas2r143; Tas2r27", "gene_names_refseq": "RGD1566290; Tas2r143", "protein_names_uniprotkb": "Taste receptor type 2 member 143; T2R143; T2R27; Taste receptor type 2 member 27", "protein_names_refseq": "T2R143; T2R27; taste receptor type 2 member 143; taste receptor type 2 member 27", "tax_id": 10116, "disease": "", "pathway": " (rno:502756)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ES3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ES5-1", "uniprot_id": [ { "id": "TR124_RAT", "url": "https://www.uniprot.org/uniprot/Q67ES5", "type": "external" } ], "mass": 35786.0, "length": 309, "protein_name": "Taste receptor type 2 member 124", "gene_name": "Tas2r124", "organism": "Rat", "refseq_name": "taste receptor type 2 member 124", "refseq_ac": [ { "id": "NP_001074407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074407", "type": "external" } ], "gene_names_uniprotkb": "Tas2r124; T2r25", "gene_names_refseq": "Tas2r124", "protein_names_uniprotkb": "Taste receptor type 2 member 124; T2R124; T2R25; Taste receptor type 2 member 25", "protein_names_refseq": "T2R124; putative taste receptor T2R25; taste receptor type 2 member 124; taste receptor type 2 member 25", "tax_id": 10116, "disease": "", "pathway": " (rno:690472)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ES5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ES6-1", "uniprot_id": [ { "id": "TR129_RAT", "url": "https://www.uniprot.org/uniprot/Q67ES6", "type": "external" } ], "mass": 37033.0, "length": 315, "protein_name": "Taste receptor type 2 member 129", "gene_name": "Tas2r129", "organism": "Rat", "refseq_name": "taste receptor type 2 member 129", "refseq_ac": [ { "id": "NP_001160155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160155", "type": "external" } ], "gene_names_uniprotkb": "Tas2r129; T2r24", "gene_names_refseq": "Tas2r129", "protein_names_uniprotkb": "Taste receptor type 2 member 129; T2R129; T2R24; Taste receptor type 2 member 24", "protein_names_refseq": "T2R129; T2R24; taste receptor type 2 member 129; taste receptor type 2 member 24", "tax_id": 10116, "disease": "", "pathway": " (rno:100310881)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ES6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ES7-1", "uniprot_id": [ { "id": "TR134_RAT", "url": "https://www.uniprot.org/uniprot/Q67ES7", "type": "external" } ], "mass": 38062.0, "length": 329, "protein_name": "Taste receptor type 2 member 134", "gene_name": "Tas2r134", "organism": "Rat", "refseq_name": "taste receptor type 2 member 134", "refseq_ac": [ { "id": "NP_001013937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013937", "type": "external" } ], "gene_names_uniprotkb": "Tas2r134; Tas2r23; Tas2r34", "gene_names_refseq": "GPCR; T2R134; T2R23; T2R34; Tas2r134", "protein_names_uniprotkb": "Taste receptor type 2 member 134; T2R134; T2R23; T2R34; Taste receptor type 2 member 23", "protein_names_refseq": "taste receptor type 2 member 134; taste receptor type 2 member 23", "tax_id": 10116, "disease": "", "pathway": " (rno:295589)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15886333", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4VHE8", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q67ES7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ES9-1", "uniprot_id": [ { "id": "TR104_RAT", "url": "https://www.uniprot.org/uniprot/Q67ES9", "type": "external" } ], "mass": 35103.0, "length": 302, "protein_name": "Taste receptor type 2 member 104", "gene_name": "Tas2r104", "organism": "Rat", "refseq_name": "taste receptor type 2 member 104", "refseq_ac": [ { "id": "NP_001160153", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160153", "type": "external" } ], "gene_names_uniprotkb": "Tas2r104; Tas2r21", "gene_names_refseq": "Tas2r104", "protein_names_uniprotkb": "Taste receptor type 2 member 104; T2R104; T2R21; Taste receptor type 2 member 21", "protein_names_refseq": "T2R104; T2R21; taste receptor type 2 member 104; taste receptor type 2 member 21", "tax_id": 10116, "disease": "", "pathway": " (rno:100310879)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ES9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ET1-1", "uniprot_id": [ { "id": "TR106_RAT", "url": "https://www.uniprot.org/uniprot/Q67ET1", "type": "external" } ], "mass": 35326.0, "length": 307, "protein_name": "Taste receptor type 2 member 106", "gene_name": "Tas2r106", "organism": "Rat", "refseq_name": "taste receptor type 2 member 106", "refseq_ac": [ { "id": "NP_001160152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160152", "type": "external" } ], "gene_names_uniprotkb": "Tas2r106; Tas2r19", "gene_names_refseq": "Tas2r106", "protein_names_uniprotkb": "Taste receptor type 2 member 106; T2R106; T2R19; Taste receptor type 2 member 19", "protein_names_refseq": "T2R106; T2R19; taste receptor type 2 member 106; taste receptor type 2 member 19", "tax_id": 10116, "disease": "", "pathway": " (rno:100310878)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ET1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ET2-1", "uniprot_id": [ { "id": "T2R40_RAT", "url": "https://www.uniprot.org/uniprot/Q67ET2", "type": "external" } ], "mass": 36957.0, "length": 319, "protein_name": "Taste receptor type 2 member 40", "gene_name": "Tas2r40", "organism": "Rat", "refseq_name": "taste receptor type 2 member 40", "refseq_ac": [ { "id": "NP_001020321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020321", "type": "external" } ], "gene_names_uniprotkb": "Tas2r40; T2r18; Tas2r144", "gene_names_refseq": "RGD1562314; Tas2r144; Tas2r40", "protein_names_uniprotkb": "Taste receptor type 2 member 40; T2R18; T2R40; Taste receptor type 2 member 144; Taste receptor type 2 member 18", "protein_names_refseq": "T2R18; T2R40; taste receptor type 2 member 18; taste receptor type 2 member 40; taste receptor, type 2, member 40", "tax_id": 10116, "disease": "", "pathway": " (rno:500101); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "31352039", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)., [UniProtKB, UniProtKB]; The bitter receptors Tas2r109, Tas2r144, and the taste-related genes Plcb2 and Trpm5 were down-regulated by ovarian hormones, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q67ET2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ET3-1", "uniprot_id": [ { "id": "TR120_RAT", "url": "https://www.uniprot.org/uniprot/Q67ET3", "type": "external" } ], "mass": 33578.0, "length": 295, "protein_name": "Taste receptor type 2 member 120", "gene_name": "Tas2r120", "organism": "Rat", "refseq_name": "taste receptor type 2 member 120", "refseq_ac": [ { "id": "NP_001074406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074406", "type": "external" } ], "gene_names_uniprotkb": "Tas2r120; T2r17", "gene_names_refseq": "Tas2r120", "protein_names_uniprotkb": "Taste receptor type 2 member 120; T2R120; T2R17; Taste receptor type 2 member 17", "protein_names_refseq": "T2R120; putative taste receptor T2R17; taste receptor type 2 member 120; taste receptor type 2 member 17", "tax_id": 10116, "disease": "", "pathway": " (rno:690448); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ET3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ET5-1", "uniprot_id": [ { "id": "TR103_RAT", "url": "https://www.uniprot.org/uniprot/Q67ET5", "type": "external" } ], "mass": 34961.0, "length": 312, "protein_name": "Taste receptor type 2 member 103", "gene_name": "Tas2r103", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tas2r103; Tas2r15", "gene_names_refseq": "", "protein_names_uniprotkb": "Taste receptor type 2 member 103; T2R103; T2R15; Taste receptor type 2 member 15", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:100310886)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ET5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q67ET7-1", "uniprot_id": [ { "id": "TA2R3_RAT", "url": "https://www.uniprot.org/uniprot/Q67ET7", "type": "external" } ], "mass": 36265.0, "length": 316, "protein_name": "Taste receptor type 2 member 3", "gene_name": "Tas2r3", "organism": "Rat", "refseq_name": "taste receptor type 2 member 3", "refseq_ac": [ { "id": "NP_001020320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020320", "type": "external" } ], "gene_names_uniprotkb": "Tas2r3; Tas2r137", "gene_names_refseq": "RGD1560602; Tas2r137; Tas2r3", "protein_names_uniprotkb": "Taste receptor type 2 member 3; T2R11; T2R3; Taste receptor type 2 member 137", "protein_names_refseq": "T2R11; T2R3; taste receptor type 2 member 3", "tax_id": 10116, "disease": "", "pathway": " (rno:500089); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q67ET7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68A65-1", "uniprot_id": [ { "id": "SPT21_RAT", "url": "https://www.uniprot.org/uniprot/Q68A65", "type": "external" } ], "mass": 75826.0, "length": 685, "protein_name": "Spermatogenesis-associated protein 21", "gene_name": "Spata21", "organism": "Rat", "refseq_name": "spermatogenesis-associated protein 21", "refseq_ac": [ { "id": "NP_001004447", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004447", "type": "external" } ], "gene_names_uniprotkb": "Spata21; Spergen3", "gene_names_refseq": "Spata21; Spergen3", "protein_names_uniprotkb": "Spermatogenesis-associated protein 21; Spergen-3; Spermatogenic cell-specific gene 3 protein", "protein_names_refseq": "spergen-3; spermatogenesis-associated protein 21; spermatogenic cell-specific gene 3 protein", "tax_id": 10116, "disease": "", "pathway": " (rno:366491)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15477360", "class_list": "", "function": "Involved in the differentiation of haploid spermatids., [UniProtKB, PubMed]; Potential role of Spergen-3, a new member of EF-hand family, in differentiation of haploid spermatids in testis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68A65-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68AX7-1", "uniprot_id": [ { "id": "REG4_RAT", "url": "https://www.uniprot.org/uniprot/Q68AX7", "type": "external" } ], "mass": 18269.0, "length": 157, "protein_name": "Regenerating islet-derived protein 4", "gene_name": "Reg4", "organism": "Rat", "refseq_name": "regenerating islet-derived protein 4 precursor", "refseq_ac": [ { "id": "NP_001004096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004096", "type": "external" } ], "gene_names_uniprotkb": "Reg4", "gene_names_refseq": "Reg4", "protein_names_uniprotkb": "Regenerating islet-derived protein 4; REG-4", "protein_names_refseq": "REG-4; regenerating islet-derived family, member 4; regenerating islet-derived protein 4 precursor; regenerating islet-derived protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:445583)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21168191;36293268", "class_list": "", "function": "Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity)., [UniProtKB]; Reg IV expression in different rat organs, which may help elucidate a potential role in growth and proliferation of different cells like other members of the Reg family genes which act as growth factors in the different organs, [RefSeq, PubMed]; Upregulation of Reg IV and Hgf mRNAs by Intermittent Hypoxia via Downregulation of microRNA-499 in Cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:2001065 mannan binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q68AX7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FS1-1", "uniprot_id": [ { "id": "NUBP2_RAT", "url": "https://www.uniprot.org/uniprot/Q68FS1", "type": "external" } ], "mass": 28926.0, "length": 271, "protein_name": "Cytosolic Fe-S cluster assembly factor NUBP2", "gene_name": "Nubp2", "organism": "Rat", "refseq_name": "cytosolic Fe-S cluster assembly factor NUBP2", "refseq_ac": [ { "id": "NP_001011891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011891", "type": "external" } ], "gene_names_uniprotkb": "Nubp2; NUBP2", "gene_names_refseq": "Nubp2", "protein_names_uniprotkb": "Cytosolic Fe-S cluster assembly factor NUBP2; NBP 2; Nucleotide-binding protein 2", "protein_names_refseq": "NBP 2; cytosolic Fe-S cluster assembly factor NUBP2; nucleotide binding protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:287125)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051536 iron-sulfur cluster binding;GO:0140663 ATP-dependent FeS chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005814 centriole;GO:0005930 axoneme;GO:0031616 spindle pole centrosome", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q68FS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FT6-1", "uniprot_id": [ { "id": "RHBG_RAT", "url": "https://www.uniprot.org/uniprot/Q68FT6", "type": "external" } ], "mass": 49731.0, "length": 455, "protein_name": "Ammonium transporter Rh type B", "gene_name": "Rhbg", "organism": "Rat", "refseq_name": "ammonium transporter Rh type B", "refseq_ac": [ { "id": "NP_898877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898877", "type": "external" } ], "gene_names_uniprotkb": "Rhbg", "gene_names_refseq": "Rhbg", "protein_names_uniprotkb": "Ammonium transporter Rh type B; Rh family type B glycoprotein; Rh type B glycoprotein; Rhesus blood group family type B glycoprotein", "protein_names_refseq": "Rh type B glycoprotein; Rhesus blood group-associated B glycoprotein; ammonium transporter Rh type B; rh family type B glycoprotein; rhesus blood group family type B glycoprotein", "tax_id": 10116, "disease": "", "pathway": " (rno:310625); (R-RNO-444411)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "12595489;15611082;16227429;17652373;20392801;21753075;29393594", "class_list": "", "function": "Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (By similarity). May act as a CO2 channel providing for renal acid secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Expression of Rhbg and Rhcg parallels intercalated cell development and that immature Rhbg and Rhcg expression at birth contributes to incomplete ammonia excretion capacity., [RefSeq, PubMed]; In hypokalemia, Rhbg protein expression was decreased slightly in the kidney cortex and not detectably altered in the outer medulla., [RefSeq, PubMed]; Rhbg expression was unchanged in hypertrophy of both intercalated cells and principal cells in the cortical and outer medullary collecting duct, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7TNP0", "ec_number_list": [], "go_molecular_function": "GO:0008519 ammonium channel activity;GO:0035379 carbon dioxide transmembrane transporter activity;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0014731 spectrin-associated cytoskeleton", "go_biological_process": "GO:0097272 ammonium homeostasis;GO:0070634 transepithelial ammonium transport;GO:0072488 ammonium transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q68FT6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FV8-1", "uniprot_id": [ { "id": "UBTD1_RAT", "url": "https://www.uniprot.org/uniprot/Q68FV8", "type": "external" } ], "mass": 25958.0, "length": 227, "protein_name": "Ubiquitin domain-containing protein 1", "gene_name": "Ubtd1", "organism": "Rat", "refseq_name": "ubiquitin domain-containing protein 1", "refseq_ac": [ { "id": "NP_001013171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013171", "type": "external" } ], "gene_names_uniprotkb": "Ubtd1", "gene_names_refseq": "Ubtd1", "protein_names_uniprotkb": "Ubiquitin domain-containing protein 1", "protein_names_refseq": "ubiquitin domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:309373)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FV8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FW6-1", "uniprot_id": [ { "id": "PPR36_RAT", "url": "https://www.uniprot.org/uniprot/Q68FW6", "type": "external" } ], "mass": 47760.0, "length": 411, "protein_name": "Protein phosphatase 1 regulatory subunit 36", "gene_name": "Ppp1r36", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 36", "refseq_ac": [ { "id": "NP_001013966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013966", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r36", "gene_names_refseq": "Ppp1r36; RGD1309051", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 36", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 36; uncharacterized protein C14orf50 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:299153)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity;GO:0019902 phosphatase binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68FW6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68G31-1", "uniprot_id": [ { "id": "PBLD_RAT", "url": "https://www.uniprot.org/uniprot/Q68G31", "type": "external" } ], "mass": 31687.0, "length": 288, "protein_name": "Phenazine biosynthesis-like domain-containing protein", "gene_name": "Pbld1; Pbld", "organism": "Rat", "refseq_name": "phenazine biosynthesis-like domain-containing protein", "refseq_ac": [ { "id": "NP_612539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612539", "type": "external" } ], "gene_names_uniprotkb": "Pbld1; Pbld; Mawbp", "gene_names_refseq": "Mawbp; Pbld1; Pbld", "protein_names_uniprotkb": "Phenazine biosynthesis-like domain-containing protein", "protein_names_refseq": "MAWD binding protein; phenazine biosynthesis-like domain-containing protein", "tax_id": 10116, "disease": "", "pathway": " (rno:171564)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication. Enhances IRF3-mediated innate immune signaling and promotes apoptotic cell death, thereby suppressing viral replication. Facilitates virus-induced type I interferon (IFN-I) signaling by promoting IRF3 phosphorylation. Upregulates the type I interferon (IFN-I) response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8R423", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003824 catalytic activity;GO:0016853 isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006915 apoptotic process;GO:0030277 maintenance of gastrointestinal epithelium;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002230 positive regulation of defense response to virus by host;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q68G31-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXN0-1", "uniprot_id": [ { "id": "UBAD1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXN0", "type": "external" } ], "mass": 18895.0, "length": 176, "protein_name": "UBA-like domain-containing protein 1", "gene_name": "Ubald1", "organism": "Rat", "refseq_name": "UBA-like domain-containing protein 1", "refseq_ac": [ { "id": "NP_001007669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007669", "type": "external" } ], "gene_names_uniprotkb": "Ubald1; Fam100a", "gene_names_refseq": "Fam100a; RGD1359443; Ubald1", "protein_names_uniprotkb": "UBA-like domain-containing protein 1", "protein_names_refseq": "UBA-like domain-containing protein 1; family with sequence similarity 100, member A; protein FAM100A-like; protein FAM100A", "tax_id": 10116, "disease": "", "pathway": " (rno:302941)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXN0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXN3-1", "uniprot_id": [ { "id": "TMED5_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXN3", "type": "external" } ], "mass": 26136.0, "length": 229, "protein_name": "Transmembrane emp24 domain-containing protein 5", "gene_name": "Tmed5", "organism": "Rat", "refseq_name": "transmembrane emp24 domain-containing protein 5 precursor", "refseq_ac": [ { "id": "NP_001007620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007620", "type": "external" } ], "gene_names_uniprotkb": "Tmed5", "gene_names_refseq": "LRRG00120; Tmed5", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 5; p24 family protein gamma-2; p24gamma2", "protein_names_refseq": "p24 family protein gamma-2; p24gamma2; transmembrane emp24 domain-containing protein 5 precursor; transmembrane emp24 domain-containing protein 5; transmembrane emp24 protein transport domain containing 5", "tax_id": 10116, "disease": "", "pathway": " (rno:289883); (R-RNO-3238698)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0090161 Golgi ribbon formation;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AXN3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXS4-1", "uniprot_id": [ { "id": "RENR_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXS4", "type": "external" } ], "mass": 39082.0, "length": 350, "protein_name": "Renin receptor", "gene_name": "Atp6ap2", "organism": "Rat", "refseq_name": "renin receptor precursor", "refseq_ac": [ { "id": "NP_001007092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007092", "type": "external" } ], "gene_names_uniprotkb": "Atp6ap2; Atp6ip2", "gene_names_refseq": "Atp6ap2", "protein_names_uniprotkb": "Renin receptor; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; Renin/prorenin receptor", "protein_names_refseq": "ATPase, H(+)-transporting, lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal accessory protein 2; renin receptor precursor; renin receptor; renin/prorenin receptor", "tax_id": 10116, "disease": "congenital disorder of glycosylation type IIr (Disease Ontology:DOID:0051048); syndromic X-linked intellectual disability (Disease Ontology:DOID:0060309); syndromic X-linked intellectual disability Hedera type (Disease Ontology:DOID:0060806); X-linked parkinsonism-spasticity syndrome (Disease Ontology:DOID:0112105); hypertension (Disease Ontology:DOID:10763); congenital disorder of glycosylation (Disease Ontology:DOID:5212)", "pathway": " (rno:302526); (R-RNO-2022377); (R-RNO-6798695)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "15489960;18212268;29393594;32165585;32830537;33547400;34087284;34228176;37286698", "class_list": "", "function": "(Pro)renin receptor involves in myocardial fibrosis and oxidative stress in diabetic cardiomyopathy via the PRR-YAP pathway. Publication Status: Online-Only, [RefSeq, PubMed]; (Pro)renin receptor promotes crescent formation via the ERK1/2 and Wnt/beta-catenin pathways in glomerulonephritis., [RefSeq, PubMed]; ATP6AP2 is robustly expressed in pancreatic beta cells and neuroendocrine tumors, and plays a role in maintaining cellular viability. Publication Status: Online-Only, [RefSeq, PubMed]; Blockade of the (pro)renin receptor (P)RR with 'handle-region' peptide (HRP) does not improve target organ damage in renovascular hypertensive rats., [RefSeq, PubMed]; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system (By similarity). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (By similarity). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Role of autophagy and evaluation the effects of microRNAs 214, 132, 34c and prorenin receptor in a rat model of focal segmental glomerulosclerosis., [RefSeq, PubMed]; The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005615 extracellular space;GO:0016020 membrane;GO:0030424 axon;GO:0005764 lysosome", "go_biological_process": "GO:0060323 head morphogenesis;GO:0032914 positive regulation of transforming growth factor beta1 production;GO:0021903 rostrocaudal neural tube patterning;GO:0002003 angiotensin maturation;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6AXS4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXV2-1", "uniprot_id": [ { "id": "TEKT4_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXV2", "type": "external" } ], "mass": 52148.0, "length": 447, "protein_name": "Tektin-4", "gene_name": "Tekt4", "organism": "Rat", "refseq_name": "tektin-4", "refseq_ac": [ { "id": "NP_001013987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013987", "type": "external" } ], "gene_names_uniprotkb": "Tekt4; Tek4", "gene_names_refseq": "RGD1308075; Tek4; Tekt4; Tektin4", "protein_names_uniprotkb": "Tektin-4", "protein_names_refseq": "tektin-4", "tax_id": 10116, "disease": "", "pathway": " (rno:302991)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15948161;16596631", "class_list": "", "function": "Data suggest that Tektin 4 is not associated with axonemal tubulins but instead associated with Outer Dense Fibers in rodent spermatozoa., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Contributes to normal sperm motility (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Tektin4 protein was predominantly localized in the flagella of spermatozoa, suggesting that it might works as a flagellar component requisite for flagellar stability or sperm motility, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0097229 sperm end piece;GO:0015630 microtubule cytoskeleton;GO:0036126 sperm flagellum;GO:0097228 sperm principal piece;GO:0005879 axonemal microtubule", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0060378 regulation of brood size;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AXV2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXW8-1", "uniprot_id": [ { "id": "TMM81_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXW8", "type": "external" } ], "mass": 28886.0, "length": 262, "protein_name": "Transmembrane protein 81", "gene_name": "Tmem81", "organism": "Rat", "refseq_name": "transmembrane protein 81 precursor", "refseq_ac": [ { "id": "NP_001017490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017490", "type": "external" } ], "gene_names_uniprotkb": "Tmem81", "gene_names_refseq": "Tmem81", "protein_names_uniprotkb": "Transmembrane protein 81", "protein_names_refseq": "transmembrane protein 81 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:498229)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential fertilization factor required for male fertility. Part of a conserved trimeric sperm complex with the essential fertilization factors IZUMO1 and SPACA6 which bridges sperm and oocyte membranes during fertilization by binding to IZUMO1R/JUNO on the oocyte., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0035036 sperm-egg recognition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXW8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AXZ0-1", "uniprot_id": [ { "id": "PAIP2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AXZ0", "type": "external" } ], "mass": 14700.0, "length": 124, "protein_name": "Polyadenylate-binding protein-interacting protein 2", "gene_name": "Paip2", "organism": "Rat", "refseq_name": "polyadenylate-binding protein-interacting protein 2", "refseq_ac": [ { "id": "NP_001014170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014170", "type": "external" } ], "gene_names_uniprotkb": "Paip2", "gene_names_refseq": "Paip2", "protein_names_uniprotkb": "Polyadenylate-binding protein-interacting protein 2; PABP-interacting protein 2; PAIP-2; Poly(A)-binding protein-interacting protein 2", "protein_names_refseq": "PABP-interacting protein 2; PAIP-2; polyadenylate-binding protein-interacting protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:361309)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003729 mRNA binding;GO:0030371 translation repressor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0007613 memory;GO:0017148 negative regulation of translation;GO:0045947 negative regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AXZ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY46-1", "uniprot_id": [ { "id": "TRM61_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY46", "type": "external" } ], "mass": 31619.0, "length": 290, "protein_name": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A", "gene_name": "Trmt61a", "organism": "Rat", "refseq_name": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A", "refseq_ac": [ { "id": "NP_001007707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007707", "type": "external" } ], "gene_names_uniprotkb": "Trmt61a; Trm61", "gene_names_refseq": "Gcd14; RGD1359191; Trm61; Trmt61a", "protein_names_uniprotkb": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; 2.1.1.-; 2.1.1.220; mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRMT61A", "protein_names_refseq": "GCD14 and PCMT domain containing protein RGD1359191; GCD14/PCMT domain containing protein RGD1359191; mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61; tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A; tRNA methyltransferase 61 homolog A; tRNA(m1A58)-methyltransferase subunit TRM61; tRNA(m1A58)-methyltransferase subunit TRMT61A; tRNA(m1A58)MTase subunit TRM61; tRNA(m1A58)MTase subunit TRMT61A", "tax_id": 10116, "disease": "", "pathway": " (rno:314462)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" }, { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" }, { "id": "2.1.1.220", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.220", "type": "external" } ], "go_molecular_function": "GO:0061953 mRNA (adenine-N1-)-methyltransferase activity;GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031515 tRNA (m1A) methyltransferase complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY46-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY57-1", "uniprot_id": [ { "id": "WIPI2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY57", "type": "external" } ], "mass": 48519.0, "length": 445, "protein_name": "WD repeat domain phosphoinositide-interacting protein 2", "gene_name": "Wipi2", "organism": "Rat", "refseq_name": "WD repeat domain phosphoinositide-interacting protein 2", "refseq_ac": [ { "id": "NP_001007616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007616", "type": "external" } ], "gene_names_uniprotkb": "Wipi2", "gene_names_refseq": "Wipi2", "protein_names_uniprotkb": "WD repeat domain phosphoinositide-interacting protein 2; WIPI-2", "protein_names_refseq": "WD repeat domain phosphoinositide-interacting protein 2; WIPI-2", "tax_id": 10116, "disease": "Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (rno:288498); (R-RNO-1632852)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0030674 protein-macromolecule adaptor activity;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005829 cytosol;GO:0016020 membrane;GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0034497 protein localization to phagophore assembly site;GO:0061739 protein lipidation involved in autophagosome assembly;GO:0098792 xenophagy;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AY57-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY78-1", "uniprot_id": [ { "id": "S67A1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY78", "type": "external" } ], "mass": 43818.0, "length": 412, "protein_name": "Solute carrier family 22 member 18", "gene_name": "Slc22a18; Slc67a1", "organism": "Rat", "refseq_name": "solute carrier family 22 member 18", "refseq_ac": [ { "id": "NP_001004260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004260", "type": "external" } ], "gene_names_uniprotkb": "Slc22a18; Slc67a1; Orctl2; Slc22a18; Tssc5", "gene_names_refseq": "Slc22a18; Slc67a1", "protein_names_uniprotkb": "Solute carrier family 22 member 18; ORCTL-2; Organic cation transporter-like protein 2", "protein_names_refseq": "ORCTL-2; organic cation transporter-like protein 2; solute carrier family 22 (organic cation transporter), member 18; solute carrier family 22 member 18; tumor suppressing subtransferable candidate 5", "tax_id": 10116, "disease": "lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); colon adenocarcinoma (Disease Ontology:DOID:234); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); esophagus adenocarcinoma (Disease Ontology:DOID:4914)", "pathway": " (rno:309131); (R-RNO-549127)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21454685;24099777", "class_list": "", "function": "May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (By similarity). Plays a role in the regulation of lipid metabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results reveal a novel link between Slc22a18 and fat accumulation and suggest that this gene could be a new therapeutic target in obesity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JSS3", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0015293 symporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0016324 apical plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0042908 xenobiotic transport;GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AY78-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYA5-1", "uniprot_id": [ { "id": "T106B_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYA5", "type": "external" } ], "mass": 31152.0, "length": 275, "protein_name": "Transmembrane protein 106B", "gene_name": "Tmem106b", "organism": "Rat", "refseq_name": "transmembrane protein 106B", "refseq_ac": [ { "id": "NP_001004267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004267", "type": "external" } ], "gene_names_uniprotkb": "Tmem106b", "gene_names_refseq": "LRRGT00101; Tmem106b", "protein_names_uniprotkb": "Transmembrane protein 106B", "protein_names_refseq": "transmembrane protein 106B", "tax_id": 10116, "disease": "hypomyelinating leukodystrophy 16 (Disease Ontology:DOID:0070405)", "pathway": " (rno:312132)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24090084;24357581", "class_list": "", "function": "In neurons, involved in the transport of late endosomes/lysosomes (PubMed:24357581). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:24357581). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (PubMed:24357581). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is particularly important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (By similarity). Required for proper lysosomal acidification (By similarity)., [UniProtKB, UniProtKB, PubMed]; Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking. May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (PubMed:24357581). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (By similarity). Required for proper lysosomal acidification (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 7, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0007040 lysosome organization;GO:0048813 dendrite morphogenesis;GO:0051345 positive regulation of hydrolase activity;GO:0007041 lysosomal transport;GO:0032418 lysosome localization", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6AYA5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYD9-1", "uniprot_id": [ { "id": "NUD19_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYD9", "type": "external" } ], "mass": 39939.0, "length": 357, "protein_name": "Acyl-coenzyme A diphosphatase NUDT19", "gene_name": "Nudt19", "organism": "Rat", "refseq_name": "acyl-coenzyme A diphosphatase NUDT19 precursor", "refseq_ac": [ { "id": "NP_001004258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004258", "type": "external" } ], "gene_names_uniprotkb": "Nudt19", "gene_names_refseq": "Nudt19", "protein_names_uniprotkb": "Acyl-coenzyme A diphosphatase NUDT19; 3.6.1.-; 3.6.1.77; Nucleoside diphosphate-linked moiety X motif 19; Nudix motif 19", "protein_names_refseq": "acyl-coenzyme A diphosphatase NUDT19 precursor; acyl-coenzyme A diphosphatase NUDT19; nucleoside diphosphate-linked moiety X motif 19, mitochondrial; nudix (nucleoside diphosphate linked moiety X)-type motif 19; nudix motif 19", "tax_id": 10116, "disease": "", "pathway": " (rno:308518); (R-RNO-390918); (R-RNO-9033241)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" }, { "id": "3.6.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.2.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.5", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.64", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "2.3.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "3.6.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.17", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0036114 medium-chain fatty-acyl-CoA catabolic process;GO:2001294 malonyl-CoA catabolic process;GO:0015938 coenzyme A catabolic process;GO:0044580 butyryl-CoA catabolic process;GO:1901289 succinyl-CoA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYD9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYE3-1", "uniprot_id": [ { "id": "TAD2A_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYE3", "type": "external" } ], "mass": 51399.0, "length": 443, "protein_name": "Transcriptional adapter 2-alpha", "gene_name": "Tada2a", "organism": "Rat", "refseq_name": "transcriptional adapter 2-alpha", "refseq_ac": [ { "id": "NP_001012141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012141", "type": "external" } ], "gene_names_uniprotkb": "Tada2a; Tada2l", "gene_names_refseq": "Tada2a; Tada2l", "protein_names_uniprotkb": "Transcriptional adapter 2-alpha; ADA2-like protein; Transcriptional adapter 2-like", "protein_names_refseq": "ADA2-like protein; transcriptional adapter 2-alpha", "tax_id": 10116, "disease": "", "pathway": " (rno:360581); (R-RNO-9772755)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17218081", "class_list": "", "function": "Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1EC76", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0070461 SAGA-type complex;GO:0005634 nucleus;GO:0000124 SAGA complex;GO:0072686 mitotic spindle;GO:0140672 ATAC complex", "go_biological_process": "GO:0090043 regulation of tubulin deacetylation;GO:0000278 mitotic cell cycle;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYE3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYJ8-1", "uniprot_id": [ { "id": "TP8L2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYJ8", "type": "external" } ], "mass": 20751.0, "length": 184, "protein_name": "Tumor necrosis factor alpha-induced protein 8-like protein 2", "gene_name": "Tnfaip8l2", "organism": "Rat", "refseq_name": "tumor necrosis factor alpha-induced protein 8-like protein 2", "refseq_ac": [ { "id": "NP_001014061", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014061", "type": "external" } ], "gene_names_uniprotkb": "Tnfaip8l2", "gene_names_refseq": "RGD1310519; Tnfaip8l2", "protein_names_uniprotkb": "Tumor necrosis factor alpha-induced protein 8-like protein 2; TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2", "protein_names_refseq": "TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; tumor necrosis factor alpha-induced protein 8-like protein 2; tumor necrosis factor, alpha-induced protein 8-like 2; tumor necrosis factor, alpha-induced protein 8-like protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:310663); (R-RNO-1483255)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "27666960;28849230;32333940;35842555;37493703", "class_list": "", "function": "Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (By similarity). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (By similarity). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Exogenous TIPE2 Inhibit TAK1 to Improve Inflammation and Neuropathic Pain Induced by Sciatic Nerve Injury Through Inactivating NF-kappaB and JNK., [RefSeq, PubMed]; Expression and regulation of tumor necrosis factor-alpha-induced protein-8-like 2 is associated with acute lung injury induced by myocardial ischemia reperfusion in diabetic rats., [RefSeq, PubMed]; Expression of tumor necrosis factor (TNF)alphainduced protein 8-like 2 (TIPE2), matrix metalloproteinase-9 (MMP-9) and heme oxygenase-1 (HO-1) and mitogen-activated protein kinase (MAPK) signaling was modulated by Xuebijing injection (XBJ)., [RefSeq, PubMed]; TIPE2 regulates lipopolysaccharide-induced rat rheumatoid arthritis immune responses and is associated with Rac1 activation and IRF3 phosphorylation., [RefSeq, PubMed]; TIPE2 regulates periodontal inflammation by inhibiting NF-kappaB p65 phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0045087 innate immune response;GO:0050728 negative regulation of inflammatory response;GO:0042981 regulation of apoptotic process;GO:1902531 regulation of intracellular signal transduction;GO:0050868 negative regulation of T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6AYJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYL4-1", "uniprot_id": [ { "id": "RIBC1_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYL4", "type": "external" } ], "mass": 44480.0, "length": 378, "protein_name": "RIB43A-like with coiled-coils protein 1", "gene_name": "Ribc1", "organism": "Rat", "refseq_name": "RIB43A-like with coiled-coils protein 1", "refseq_ac": [ { "id": "NP_001007716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007716", "type": "external" } ], "gene_names_uniprotkb": "Ribc1", "gene_names_refseq": "Ribc1", "protein_names_uniprotkb": "RIB43A-like with coiled-coils protein 1", "protein_names_refseq": "RIB43A-like with coiled-coils protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:317431)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYL9-1", "uniprot_id": [ { "id": "NUF2_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYL9", "type": "external" } ], "mass": 54556.0, "length": 464, "protein_name": "Kinetochore protein Nuf2", "gene_name": "Nuf2", "organism": "Rat", "refseq_name": "kinetochore protein Nuf2", "refseq_ac": [ { "id": "NP_001012028", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012028", "type": "external" } ], "gene_names_uniprotkb": "Nuf2; Cdca1", "gene_names_refseq": "Cdca1; Nuf2", "protein_names_uniprotkb": "Kinetochore protein Nuf2; Cell division cycle-associated protein 1", "protein_names_refseq": "NDC80 kinetochore complex component NUF2; NUF2, NDC80 kinetochore complex component, homolog; cell division cycle associated 1; cell division cycle-associated protein 1; kinetochore protein Nuf2", "tax_id": 10116, "disease": "oral cavity carcinoma in situ (Disease Ontology:DOID:0050610); castration-resistant prostate carcinoma (Disease Ontology:DOID:0080909); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:304951); (R-RNO-141430); (R-RNO-141444); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-5663220); (R-RNO-68877); (R-RNO-9648025)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005654 nucleoplasm;GO:0000776 kinetochore;GO:0000940 outer kinetochore;GO:0005634 nucleus", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051383 kinetochore organization;GO:0008608 attachment of spindle microtubules to kinetochore;GO:0051301 cell division;GO:0045132 meiotic chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYL9-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYN2-1", "uniprot_id": [ { "id": "SARAF_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYN2", "type": "external" } ], "mass": 35885.0, "length": 334, "protein_name": "Store-operated calcium entry-associated regulatory factor", "gene_name": "Saraf", "organism": "Rat", "refseq_name": "store-operated calcium entry-associated regulatory factor precursor", "refseq_ac": [ { "id": "NP_001004213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004213", "type": "external" } ], "gene_names_uniprotkb": "Saraf; Tmem66", "gene_names_refseq": "Saraf; Tmem66", "protein_names_uniprotkb": "Store-operated calcium entry-associated regulatory factor; SARAF; SOCE-associated regulatory factor; Transmembrane protein 66", "protein_names_refseq": "SOCE-associated regulatory factor; arrestin-E; store-operated calcium entry-associated regulatory factor precursor; transmembrane protein 66", "tax_id": 10116, "disease": "", "pathway": " (rno:290796)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "29393594;31173198", "class_list": "", "function": "Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TMEM66 attenuates neointimal hyperplasia after carotid artery injury by SOCE inactivation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0006816 calcium ion transport;GO:2001256 regulation of store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6AYN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYN4-1", "uniprot_id": [ { "id": "PHIPL_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYN4", "type": "external" } ], "mass": 42412.0, "length": 375, "protein_name": "Phytanoyl-CoA hydroxylase-interacting protein-like", "gene_name": "Phyhipl", "organism": "Rat", "refseq_name": "phytanoyl-CoA hydroxylase-interacting protein-like isoform 1", "refseq_ac": [ { "id": "NP_001012076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012076", "type": "external" } ], "gene_names_uniprotkb": "Phyhipl", "gene_names_refseq": "Phyhipl", "protein_names_uniprotkb": "Phytanoyl-CoA hydroxylase-interacting protein-like", "protein_names_refseq": "phytanoyl-CoA hydroxylase-interacting protein-like isoform 1; phytanoyl-CoA hydroxylase-interacting protein-like", "tax_id": 10116, "disease": "", "pathway": " (rno:309901)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "May play a role in the development of the central system., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6AYN4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYS5-1", "uniprot_id": [ { "id": "TMM98_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYS5", "type": "external" } ], "mass": 24684.0, "length": 226, "protein_name": "Transmembrane protein 98", "gene_name": "Tmem98", "organism": "Rat", "refseq_name": "transmembrane protein 98", "refseq_ac": [ { "id": "NP_001007673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007673", "type": "external" } ], "gene_names_uniprotkb": "Tmem98", "gene_names_refseq": "Tmem98", "protein_names_uniprotkb": "Transmembrane protein 98", "protein_names_refseq": "transmembrane protein 98", "tax_id": 10116, "disease": "nanophthalmos (Disease Ontology:DOID:0080634)", "pathway": " (rno:303356)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0070062 extracellular exosome", "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:1900181 negative regulation of protein localization to nucleus;GO:0031642 negative regulation of myelination;GO:0048715 negative regulation of oligodendrocyte differentiation;GO:0010955 negative regulation of protein processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AYS5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6B345-1", "uniprot_id": [ { "id": "S10AB_RAT", "url": "https://www.uniprot.org/uniprot/Q6B345", "type": "external" } ], "mass": 11065.0, "length": 98, "protein_name": "Protein S100-A11", "gene_name": "S100a11", "organism": "Rat", "refseq_name": "protein S100-A11", "refseq_ac": [ { "id": "NP_001004095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004095", "type": "external" } ], "gene_names_uniprotkb": "S100a11", "gene_names_refseq": "S100a11", "protein_names_uniprotkb": "Protein S100-A11; Calgizzarin; S100 calcium-binding protein A11", "protein_names_refseq": "S100 calcium binding protein A11 (calizzarin); calgizzarin; protein S100-A11", "tax_id": 10116, "disease": "", "pathway": " (rno:445415); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "35419674", "class_list": "", "function": "Facilitates the differentiation and the cornification of keratinocytes., [UniProtKB]; Inhibitory Effect of S100A11 on Airway Smooth Muscle Contraction and Airway Hyperresponsiveness., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0014911 positive regulation of smooth muscle cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6B345-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6EIX2-1", "uniprot_id": [ { "id": "TIM16_RAT", "url": "https://www.uniprot.org/uniprot/Q6EIX2", "type": "external" } ], "mass": 13730.0, "length": 124, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM16", "gene_name": "AABR07030524.1; Magmas-ps1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AABR07030524.1; Magmas-ps1; Magmas-ps1; Magmas; Pam16; Tim16; Timm16", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM16; Mitochondria-associated granulocyte macrophage CSF-signaling molecule; Presequence translocated-associated motor subunit PAM16", "protein_names_refseq": "", "tax_id": 10116, "disease": "spondylometaphyseal dysplasia Megarbane-Dagher-Melike type (Disease Ontology:DOID:0112304); osteochondrodysplasia (Disease Ontology:DOID:2256)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15984936", "class_list": "", "function": "Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005744 TIM23 mitochondrial import inner membrane translocase complex;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0001503 ossification;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6EIX2-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GUG4-1", "uniprot_id": [ { "id": "P2Y13_RAT", "url": "https://www.uniprot.org/uniprot/Q6GUG4", "type": "external" } ], "mass": 38823.0, "length": 336, "protein_name": "P2Y purinoceptor 13", "gene_name": "P2ry13", "organism": "Rat", "refseq_name": "P2Y purinoceptor 13", "refseq_ac": [ { "id": "NP_001002853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002853", "type": "external" } ], "gene_names_uniprotkb": "P2ry13", "gene_names_refseq": "P2ry13; P2y13", "protein_names_uniprotkb": "P2Y purinoceptor 13; P2Y13", "protein_names_refseq": "P2Y purinoceptor 13; purinergic receptor P2Y, G-protein coupled, 13", "tax_id": 10116, "disease": "", "pathway": " (rno:310444); (R-RNO-417957); (R-RNO-418594)", "pathway_count": 3, "publication_count": 10, "publication_id_list": "15183123;20447456;20813187;22521313;24851838;25186167;29393594;29574630;32155290;38142931", "class_list": "", "function": "ADP-mediated intracellular calcium mobilization and Hex release in RBL-2H3 cells are via P2Y(1) and P2y13 receptors, respectively., [RefSeq, PubMed]; Gene expression of the purinergic P2Y12 subtype was detected in rat retina during early postnatal days (P0 to P5), while expression levels of P2Y13 were low., [RefSeq, PubMed]; P2Y13 and P2X7 receptors modulate mechanically induced adenosine triphosphate release from mast cells., [RefSeq, PubMed]; P2Y13 receptor in invloves in suppression of neuronal differentiation. P2Y13 receptor antagonists might be candidates for treatment of neurodegenerative diseases., [RefSeq, PubMed]; P2Y13 receptor involved in HIV-1 gp120 induced neuropathy in superior cervical ganglia through NLRP3 inflammasome activation. Review article, [RefSeq, PubMed]; P2Y13 receptors regulate DUSP2 expression and contribute to p38 signaling homeostasis and survival in granule neurons., [RefSeq, PubMed]; Rat P2rY13 receptor displays several similarities but also interesting differences with its human and mouse orthologs [P2Y(13)], [RefSeq, PubMed]; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system., [UniProtKB, PubMed]; Results show a previously unrecognized role of the purinergic P2Y13 receptor in the induction of the Nrf2/HO-1 antioxidant response and in protection against oxidative stress, [RefSeq, PubMed]; The activation of P2Y13 receptor might be involved in the effect of ADP on [Ca(2+)]i in cultured dorsal spinal cord microglia, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q6GUG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE06-1", "uniprot_id": [ { "id": "PRS58_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE06", "type": "external" } ], "mass": 26812.0, "length": 240, "protein_name": "Putative inactive serine protease 58", "gene_name": "Prss58", "organism": "Rat", "refseq_name": "putative inactive serine protease 58 precursor", "refseq_ac": [ { "id": "NP_001009174", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009174", "type": "external" } ], "gene_names_uniprotkb": "Prss58; Tryx3", "gene_names_refseq": "Prss58; Tryx3; try1", "protein_names_uniprotkb": "Putative inactive serine protease 58; 3.4.21.4; Trypsin-X3", "protein_names_refseq": "protease, serine, 58; putative inactive serine protease 58 precursor; putative inactive serine protease 58; putative trypsin-X3", "tax_id": 10116, "disease": "", "pathway": " (rno:408204)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060002;18815551", "class_list": "", "function": "Nicotine impairs secretion rather than production of pancreatic trypsinogen 1., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation;GO:2000243 positive regulation of reproductive process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6IE06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE59-1", "uniprot_id": [ { "id": "PRS57_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE59", "type": "external" } ], "mass": 29518.0, "length": 278, "protein_name": "Serine protease 57", "gene_name": "Prss57", "organism": "Rat", "refseq_name": "serine protease 57 precursor", "refseq_ac": [ { "id": "NP_001003956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003956", "type": "external" } ], "gene_names_uniprotkb": "Prss57; Df2; Prssl1", "gene_names_refseq": "Df2; NSP4; Prss57; Prssl1", "protein_names_uniprotkb": "Serine protease 57; 3.4.21.-; Complement factor D-like protein; NSP4; Neutrophil serine protease 4; Serine protease 1-like protein 1", "protein_names_refseq": "PRSSL1 homolog; complement factor D-like protein; neutrophil serine protease 4; protease, serine, 57; protease, serine-like 1; serine protease 1-like protein 1; serine protease 57 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:408241)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008201 heparin binding;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0035578 azurophil granule lumen;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE62-1", "uniprot_id": [ { "id": "PRS45_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE62", "type": "external" } ], "mass": 37303.0, "length": 330, "protein_name": "Inactive serine protease 45", "gene_name": "Prss45", "organism": "Rat", "refseq_name": "inactive serine protease 45 precursor", "refseq_ac": [ { "id": "NP_001008864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008864", "type": "external" } ], "gene_names_uniprotkb": "Prss45; Tessp5", "gene_names_refseq": "Prss45; Tessp5", "protein_names_uniprotkb": "Inactive serine protease 45; Inactive testis serine protease 5", "protein_names_refseq": "inactive serine protease 45 precursor; inactive serine protease 45; inactive testis serine protease 5; protease, serine, 45; testis-specific serine protease-5", "tax_id": 10116, "disease": "", "pathway": " (rno:408244)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE62-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IE70-1", "uniprot_id": [ { "id": "PAN2_RAT", "url": "https://www.uniprot.org/uniprot/Q6IE70", "type": "external" } ], "mass": 135627.0, "length": 1205, "protein_name": "PAN2-PAN3 deadenylation complex catalytic subunit Pan2", "gene_name": "Pan2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Pan2; PAN2; Usp52", "gene_names_refseq": "", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex catalytic subunit Pan2; 3.1.13.4; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 2; Poly(A)-nuclease deadenylation complex subunit 2", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-429947)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060002", "class_list": "", "function": "Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0031251 PAN complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IE70-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IMA7-1", "uniprot_id": [ { "id": "RSLBB_RAT", "url": "https://www.uniprot.org/uniprot/Q6IMA7", "type": "external" } ], "mass": 27291.0, "length": 247, "protein_name": "Ras-like protein family member 11B", "gene_name": "Rasl11b", "organism": "Rat", "refseq_name": "ras-like protein family member 11B", "refseq_ac": [ { "id": "NP_001002830", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002830", "type": "external" } ], "gene_names_uniprotkb": "Rasl11b", "gene_names_refseq": "Rasl11b", "protein_names_uniprotkb": "Ras-like protein family member 11B; 3.6.5.2", "protein_names_refseq": "ras-like protein family member 11B", "tax_id": 10116, "disease": "", "pathway": " (rno:305302)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15033445", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0005160 transforming growth factor beta receptor binding;GO:0003925 G protein activity", "go_cellular_component": "", "go_biological_process": "GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6IMA7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IN01-1", "uniprot_id": [ { "id": "PPR3B_RAT", "url": "https://www.uniprot.org/uniprot/Q6IN01", "type": "external" } ], "mass": 32626.0, "length": 284, "protein_name": "Protein phosphatase 1 regulatory subunit 3B", "gene_name": "Ppp1r3b", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 3B", "refseq_ac": [ { "id": "NP_620267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620267", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r3b; Ppp1r4", "gene_names_refseq": "Ppp1r3b", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 3B; 33 kDa glycogen-binding protein; Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; PP1 subunit R4; Protein phosphatase 1 regulatory subunit 4; Protein phosphatase 1 subunit GL", "protein_names_refseq": "33 kDa glycogen-binding protein; PP1 subunit R4; R4; hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; protein phosphatase 1 (GL-subunit); protein phosphatase 1 regulatory subunit 3B; protein phosphatase 1 regulatory subunit 4; protein phosphatase 1 subunit GL; protein phosphatase 1, regulatory (inhibitor) subunit 3B", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:192280)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10862764;11872655;17555403;18298402;7498521;7720853;9841883", "class_list": "", "function": "Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes., [UniProtKB, PubMed, PubMed, PubMed]; Data show that inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63759", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0019888 protein phosphatase regulator activity;GO:0008157 protein phosphatase 1 binding;GO:2001069 glycogen binding;GO:0050196 [phosphorylase] phosphatase activity", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0042587 glycogen granule", "go_biological_process": "GO:0005981 regulation of glycogen catabolic process;GO:0045818 negative regulation of glycogen catabolic process;GO:0005977 glycogen metabolic process;GO:0045725 positive regulation of glycogen biosynthetic process;GO:0005979 regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q6IN01-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IN33-1", "uniprot_id": [ { "id": "RCAN1_RAT", "url": "https://www.uniprot.org/uniprot/Q6IN33", "type": "external" } ], "mass": 22948.0, "length": 199, "protein_name": "Calcipressin-1", "gene_name": "Rcan1", "organism": "Rat", "refseq_name": "calcipressin-1 isoform 2", "refseq_ac": [ { "id": "NP_714946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714946", "type": "external" } ], "gene_names_uniprotkb": "Rcan1; Dscr1", "gene_names_refseq": "Dscr1; Mcip1; Rcan1", "protein_names_uniprotkb": "Calcipressin-1; Down syndrome critical region protein 1 homolog; MCIP1; Myocyte-enriched calcineurin-interacting protein 1; Regulator of calcineurin 1", "protein_names_refseq": "Down syndrome critical region gene 1; Down syndrome critical region homolog 1; calcipressin-1 isoform 2; calcipressin-1; down syndrome critical region protein 1 homolog; myocyte-enriched calcineurin-interacting protein 1", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); Down syndrome (Disease Ontology:DOID:14250)", "pathway": " (rno:266766)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14976250;26122706;27339639;28064310;32467610;37098739", "class_list": "", "function": "In the heart MCIP1 gene is activated by calcineurin and has been proposed to fulfill a negative feedback loop that restrains potentially pathological calcineurin signaling, [RefSeq, PubMed]; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development., [UniProtKB, UniProtKB]; MicroRNA-21-3p/Rcan1 signaling axis affects apoptosis of cardiomyocytes of sepsis rats., [RefSeq, PubMed]; RCAN1 plays a critical role in spinal cord injury., [RefSeq, PubMed]; Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla., [RefSeq, PubMed]; The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs., [RefSeq, PubMed]; We propose that increased RCAN1-4 expression and the signal transduction pathways it regulates represent important components of the physiological adaptation to exercise-induced oxidative stress., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K4S2", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003676 nucleic acid binding;GO:0030346 protein phosphatase 2B binding;GO:0004864 protein phosphatase inhibitor activity;GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002931 response to ischemia;GO:0006979 response to oxidative stress;GO:0019722 calcium-mediated signaling;GO:0007614 short-term memory;GO:0009612 response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6IN33-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6J329-1", "uniprot_id": [ { "id": "S2547_RAT", "url": "https://www.uniprot.org/uniprot/Q6J329", "type": "external" } ], "mass": 33618.0, "length": 310, "protein_name": "Solute carrier family 25 member 47", "gene_name": "Slc25a47", "organism": "Rat", "refseq_name": "solute carrier family 25 member 47", "refseq_ac": [ { "id": "NP_001001509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001509", "type": "external" } ], "gene_names_uniprotkb": "Slc25a47; Hdmcp", "gene_names_refseq": "Hdmcp; Slc24a47; Slc25a47", "protein_names_uniprotkb": "Solute carrier family 25 member 47; Hepatocellular carcinoma down-regulated mitochondrial carrier homolog; Mitochondrial NAD(+) transporter SLC25A47", "protein_names_refseq": "hepatocellular carcinoma down-regulated mitochondrial carrier homolog; mitochondrial NAD(+) transporter SLC25A47; mitochondrial hepatocellular carcinoma-downregulated carrier protein; solute carrier family 25 member 47", "tax_id": 10116, "disease": "", "pathway": " (rno:299316)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15322095;19303656;29393594", "class_list": "", "function": "HDMCP might function through promoting ATP depletion and decreasing H(2)O(2) production., [RefSeq, PubMed]; Hepatocellular carcinoma down-regulated mitochondrial carrier protein is a novel liver-specific uncoupling protein, [RefSeq, PubMed]; Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0008521 acetyl-CoA transmembrane transporter activity;GO:0051724 NAD transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6J329-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6JAM9-1", "uniprot_id": [ { "id": "NACHO_RAT", "url": "https://www.uniprot.org/uniprot/Q6JAM9", "type": "external" } ], "mass": 18473.0, "length": 167, "protein_name": "Novel acetylcholine receptor chaperone", "gene_name": "Tmem35a", "organism": "Rat", "refseq_name": "nicotinic acetylcholine receptor chaperone", "refseq_ac": [ { "id": "NP_001001799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001799", "type": "external" } ], "gene_names_uniprotkb": "Tmem35a; Nacho; Tmem35; Tuf1", "gene_names_refseq": "RSEP4; Tmem35a; Tmem35", "protein_names_uniprotkb": "Novel acetylcholine receptor chaperone; Spinal cord expression protein 4; TMEM35 gene-derived unknown factor 1; Transmembrane protein 35A", "protein_names_refseq": "TMEM35 gene-derived unknown factor 1; nicotinic acetylcholine receptor chaperone; novel acetylcholine receptor chaperone; spinal cord expression protein 4; transmembrane protein 35", "tax_id": 10116, "disease": "", "pathway": " (rno:308134)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20685870;26875622;28131622", "class_list": "", "function": "Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (By similarity). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:26875622). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; TMEM35/TUF1 is a candidate for modulating neurite outgrowth in the ZG after sodium depletion., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030548 acetylcholine receptor regulator activity", "go_cellular_component": "GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:2000010 positive regulation of protein localization to cell surface;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6JAM9-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MFY6-1", "uniprot_id": [ { "id": "PP1RB_RAT", "url": "https://www.uniprot.org/uniprot/Q6MFY6", "type": "external" } ], "mass": 13936.0, "length": 127, "protein_name": "E3 ubiquitin-protein ligase PPP1R11", "gene_name": "Ppp1r11", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase PPP1R11", "refseq_ac": [ { "id": "NP_997707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997707", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r11", "gene_names_refseq": "HCGV; Ppp1r11; Tctex5", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase PPP1R11; 2.3.2.27; Protein phosphatase 1 regulatory subunit 11", "protein_names_refseq": "E3 ubiquitin-protein ligase PPP1R11; protein phosphatase 1 regulatory subunit 11; t-complex testis expressed-5", "tax_id": 10116, "disease": "", "pathway": " (rno:294207)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6AXZ8", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0061630 ubiquitin protein ligase activity;GO:0008157 protein phosphatase 1 binding;GO:0004864 protein phosphatase inhibitor activity;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0001818 negative regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MFY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MFY8-1", "uniprot_id": [ { "id": "TRI40_RAT", "url": "https://www.uniprot.org/uniprot/Q6MFY8", "type": "external" } ], "mass": 28389.0, "length": 247, "protein_name": "E3 ubiquitin ligase TRIM40", "gene_name": "Trim40", "organism": "Rat", "refseq_name": "E3 ubiquitin ligase TRIM40", "refseq_ac": [ { "id": "NP_001009175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009175", "type": "external" } ], "gene_names_uniprotkb": "Trim40; Rnf35", "gene_names_refseq": "Rnf35; Trim40", "protein_names_uniprotkb": "E3 ubiquitin ligase TRIM40; 2.3.2.27; Probable E3 NEDD8-protein ligase; RING finger protein 35", "protein_names_refseq": "E3 ubiquitin ligase TRIM40; RING finger protein 35; probable E3 NEDD8-protein ligase; tripartite motif protein 40; tripartite motif-containing protein 40-like; tripartite motif-containing protein 40", "tax_id": 10116, "disease": "", "pathway": " (rno:365528)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Also promotes the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008385 IkappaB kinase complex", "go_biological_process": "GO:0045087 innate immune response;GO:1900181 negative regulation of protein localization to nucleus;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0042177 negative regulation of protein catabolic process;GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MFY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG07-1", "uniprot_id": [ { "id": "PRR3_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG07", "type": "external" } ], "mass": 20651.0, "length": 186, "protein_name": "Proline-rich protein 3", "gene_name": "Prr3", "organism": "Rat", "refseq_name": "proline-rich protein 3", "refseq_ac": [ { "id": "NP_997709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997709", "type": "external" } ], "gene_names_uniprotkb": "Prr3; Cat56", "gene_names_refseq": "Cat56; Prr3", "protein_names_uniprotkb": "Proline-rich protein 3; MHC class I region proline-rich protein CAT56", "protein_names_refseq": "MHC class I region proline-rich protein CAT56; proline-rich polypeptide 3; proline-rich protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:361788); (R-RNO-9770562)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN06", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004864 protein phosphatase inhibitor activity;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0000785 chromatin;GO:0072357 PTW/PP1 phosphatase complex", "go_biological_process": "GO:2000806 positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MG07-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG21-1", "uniprot_id": [ { "id": "SYVM_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG21", "type": "external" } ], "mass": 118894.0, "length": 1065, "protein_name": "Valine--tRNA ligase, mitochondrial", "gene_name": "Vars2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Vars2", "gene_names_refseq": "", "protein_names_uniprotkb": "Valine--tRNA ligase, mitochondrial; 6.1.1.9; ValRS; Valyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 10116, "disease": "myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); combined oxidative phosphorylation deficiency 20 (Disease Ontology:DOID:0111478); mitochondrial metabolism disease (Disease Ontology:DOID:700); mitochondrial encephalomyopathy (Disease Ontology:DOID:890)", "pathway": " (rno:309596)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15060004;29393594", "class_list": "", "function": "Catalyzes the attachment of valine to tRNA(Val) in a two-step reaction: valine is first activated by ATP to form Val-AMP and then transferred to the acceptor end of tRNA(Val)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004832 valine-tRNA ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006438 valyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6MG21-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG64-1", "uniprot_id": [ { "id": "VWA7_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG64", "type": "external" } ], "mass": 96045.0, "length": 892, "protein_name": "von Willebrand factor A domain-containing protein 7", "gene_name": "Vwa7", "organism": "Rat", "refseq_name": "von Willebrand factor A domain-containing protein 7 precursor", "refseq_ac": [ { "id": "NP_997664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997664", "type": "external" } ], "gene_names_uniprotkb": "Vwa7; G7c", "gene_names_refseq": "C6orf27; G7c; NG37; Vwa7", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 7; Protein G7c", "protein_names_refseq": "protein G7c; von Willebrand factor A domain-containing protein 7 precursor; von Willebrand factor A domain-containing protein 7", "tax_id": 10116, "disease": "", "pathway": " (rno:309611)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15060004", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6MG64-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6MG82-1", "uniprot_id": [ { "id": "PRRT1_RAT", "url": "https://www.uniprot.org/uniprot/Q6MG82", "type": "external" } ], "mass": 31389.0, "length": 306, "protein_name": "Proline-rich transmembrane protein 1", "gene_name": "Prrt1", "organism": "Rat", "refseq_name": "proline-rich transmembrane protein 1", "refseq_ac": [ { "id": "NP_001027456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027456", "type": "external" } ], "gene_names_uniprotkb": "Prrt1; Ng5", "gene_names_refseq": "DSPD1; Ng5; Orf31; Prrt1; SynDIG4", "protein_names_uniprotkb": "Proline-rich transmembrane protein 1; DSPD1; Dispanin subfamily D member 1; SynDIG4; Synapse differentiation-induced protein 4", "protein_names_refseq": "dispanin subfamily D member 1; proline-rich transmembrane protein 1; synapse differentiation-induced protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:406167)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15060004;22363774;22632720;26660156", "class_list": "", "function": "Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression., [UniProtKB, UniProtKB]; These results indicate that, although SynDIG4 shares sequence similarity with SynDIG1, it might act through a unique mechanism as an auxiliary factor for extrasynaptic GluA1-containing AMPA receptors, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0045211 postsynaptic membrane;GO:0030672 synaptic vesicle membrane;GO:0098839 postsynaptic density membrane;GO:0016020 membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007611 learning or memory;GO:0050808 synapse organization;GO:0060292 long-term synaptic depression;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6MG82-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NX65-1", "uniprot_id": [ { "id": "PDC10_RAT", "url": "https://www.uniprot.org/uniprot/Q6NX65", "type": "external" } ], "mass": 24355.0, "length": 210, "protein_name": "Programmed cell death protein 10", "gene_name": "Pdcd10", "organism": "Rat", "refseq_name": "programmed cell death protein 10", "refseq_ac": [ { "id": "NP_001009542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009542", "type": "external" } ], "gene_names_uniprotkb": "Pdcd10", "gene_names_refseq": "Pdcd10", "protein_names_uniprotkb": "Programmed cell death protein 10", "protein_names_refseq": "programmed cell death protein 10", "tax_id": 10116, "disease": "cerebral cavernous malformation (Disease Ontology:DOID:0060669); cerebral cavernous malformation 3 (Disease Ontology:DOID:0060671); varicocele (Disease Ontology:DOID:12337); hepatitis (Disease Ontology:DOID:2237); endometrial adenocarcinoma (Disease Ontology:DOID:2870); liver cirrhosis (Disease Ontology:DOID:5082); liver carcinoma (Disease Ontology:DOID:686)", "pathway": " (rno:494345)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20332113", "class_list": "", "function": "Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0071454 cellular response to anoxia;GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0001525 angiogenesis;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6NX65-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P3E0-1", "uniprot_id": [ { "id": "THYN1_RAT", "url": "https://www.uniprot.org/uniprot/Q6P3E0", "type": "external" } ], "mass": 26123.0, "length": 226, "protein_name": "Thymocyte nuclear protein 1", "gene_name": "Thyn1", "organism": "Rat", "refseq_name": "thymocyte nuclear protein 1", "refseq_ac": [ { "id": "NP_001007662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007662", "type": "external" } ], "gene_names_uniprotkb": "Thyn1", "gene_names_refseq": "Thyn1", "protein_names_uniprotkb": "Thymocyte nuclear protein 1", "protein_names_refseq": "thymocyte nuclear protein 1; thymocyte protein thy28", "tax_id": 10116, "disease": "", "pathway": " (rno:300470)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P3E0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P6S2-1", "uniprot_id": [ { "id": "S39AB_RAT", "url": "https://www.uniprot.org/uniprot/Q6P6S2", "type": "external" } ], "mass": 34868.0, "length": 335, "protein_name": "Zinc transporter ZIP11", "gene_name": "Slc39a11", "organism": "Rat", "refseq_name": "zinc transporter ZIP11", "refseq_ac": [ { "id": "NP_001013060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013060", "type": "external" } ], "gene_names_uniprotkb": "Slc39a11; Zip11", "gene_names_refseq": "Slc39a11", "protein_names_uniprotkb": "Zinc transporter ZIP11; Solute carrier family 39 member 11; ZIP-11; Zrt- and Irt-like protein 11", "protein_names_refseq": "ZIP-11; solute carrier family 39 (metal ion transporter), member 11; zinc transporter ZIP11; zrt- and Irt-like protein 11", "tax_id": 10116, "disease": "", "pathway": " (rno:287796)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Zinc importer that regulates cytosolic zinc concentrations either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechanism remains to be elucidated., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0005375 copper ion transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0071578 zinc ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P6S2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P756-1", "uniprot_id": [ { "id": "NECP2_RAT", "url": "https://www.uniprot.org/uniprot/Q6P756", "type": "external" } ], "mass": 28405.0, "length": 263, "protein_name": "Adaptin ear-binding coat-associated protein 2", "gene_name": "Necap2", "organism": "Rat", "refseq_name": "adaptin ear-binding coat-associated protein 2 isoform 2", "refseq_ac": [ { "id": "NP_001386017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386017", "type": "external" } ], "gene_names_uniprotkb": "Necap2", "gene_names_refseq": "Necap2", "protein_names_uniprotkb": "Adaptin ear-binding coat-associated protein 2; NECAP-2", "protein_names_refseq": "NECAP-2; adaptin ear-binding coat-associated protein 2 isoform 2; adaptin ear-binding coat-associated protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:298598); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "14555962;14766980", "class_list": "", "function": "Involved in endocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6P756-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P767-1", "uniprot_id": [ { "id": "PTTG_RAT", "url": "https://www.uniprot.org/uniprot/Q6P767", "type": "external" } ], "mass": 19900.0, "length": 174, "protein_name": "Pituitary tumor-transforming gene 1 protein-interacting protein", "gene_name": "Pttg1ip", "organism": "Rat", "refseq_name": "pituitary tumor-transforming gene 1 protein-interacting protein precursor", "refseq_ac": [ { "id": "NP_001013256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013256", "type": "external" } ], "gene_names_uniprotkb": "Pttg1ip", "gene_names_refseq": "Pttg1ip", "protein_names_uniprotkb": "Pituitary tumor-transforming gene 1 protein-interacting protein; PBF; PTTG-binding factor; Pituitary tumor-transforming gene protein-binding factor", "protein_names_refseq": "PBF; PTTG-binding factor; pituitary tumor-transforming 1 interacting protein; pituitary tumor-transforming gene 1 protein-interacting protein precursor; pituitary tumor-transforming gene 1 protein-interacting protein; pituitary tumor-transforming gene protein-binding factor", "tax_id": 10116, "disease": "", "pathway": " (rno:365548)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May facilitate PTTG1 nuclear translocation., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002039 p53 binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0031398 positive regulation of protein ubiquitination;GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P767-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P773-1", "uniprot_id": [ { "id": "TAF1C_RAT", "url": "https://www.uniprot.org/uniprot/Q6P773", "type": "external" } ], "mass": 92371.0, "length": 842, "protein_name": "TATA box-binding protein-associated factor, RNA polymerase I, subunit C", "gene_name": "Taf1c", "organism": "Rat", "refseq_name": "TATA box-binding protein-associated factor, RNA polymerase I, subunit C", "refseq_ac": [ { "id": "NP_001014177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014177", "type": "external" } ], "gene_names_uniprotkb": "Taf1c", "gene_names_refseq": "Taf1c", "protein_names_uniprotkb": "TATA box-binding protein-associated factor, RNA polymerase I, subunit C; TATA box-binding protein-associated factor 1C; TBP-associated factor 1C; Transcription initiation factor SL1/TIF-IB subunit C", "protein_names_refseq": "TATA box binding protein (Tbp)-associated factor, RNA polymerase I, C; TATA box-binding protein-associated factor 1C; TATA box-binding protein-associated factor, RNA polymerase I, subunit C; TBP-associated factor 1C; transcription initiation factor SL1/TIF-IB subunit C", "tax_id": 10116, "disease": "", "pathway": " (rno:361420); (R-RNO-5250924); (R-RNO-73762); (R-RNO-73772); (R-RNO-73863)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3 (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding;GO:0001181 RNA polymerase I general transcription initiation factor activity", "go_cellular_component": "GO:0005668 RNA polymerase transcription factor SL1 complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0001650 fibrillar center", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P773-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P798-1", "uniprot_id": [ { "id": "RCBT2_RAT", "url": "https://www.uniprot.org/uniprot/Q6P798", "type": "external" } ], "mass": 60123.0, "length": 551, "protein_name": "RCC1 and BTB domain-containing protein 2", "gene_name": "Rcbtb2", "organism": "Rat", "refseq_name": "RCC1 and BTB domain-containing protein 2", "refseq_ac": [ { "id": "NP_954515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954515", "type": "external" } ], "gene_names_uniprotkb": "Rcbtb2; Chc1l", "gene_names_refseq": "Chc1l; Rcbtb2", "protein_names_uniprotkb": "RCC1 and BTB domain-containing protein 2; Chromosome condensation 1-like; Regulator of chromosome condensation and BTB domain-containing protein 2", "protein_names_refseq": "RCC1 and BTB domain-containing protein 2; regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2; regulator of chromosome condensation and BTB domain-containing protein 2", "tax_id": 10116, "disease": "malignant histiocytic disease (Disease Ontology:DOID:2570)", "pathway": " (rno:290363)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0001889 liver development;GO:0008283 cell population proliferation;GO:0048536 spleen development;GO:0048565 digestive tract development;GO:0048535 lymph node development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P798-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9U1-1", "uniprot_id": [ { "id": "NUD22_RAT", "url": "https://www.uniprot.org/uniprot/Q6P9U1", "type": "external" } ], "mass": 33492.0, "length": 308, "protein_name": "Uridine diphosphate glucose pyrophosphatase NUDT22", "gene_name": "Nudt22", "organism": "Rat", "refseq_name": "uridine diphosphate glucose pyrophosphatase NUDT22", "refseq_ac": [ { "id": "NP_954521", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954521", "type": "external" } ], "gene_names_uniprotkb": "Nudt22", "gene_names_refseq": "Nudt22", "protein_names_uniprotkb": "Uridine diphosphate glucose pyrophosphatase NUDT22; 3.6.1.-; Nucleoside diphosphate-linked moiety X motif 22; Nudix motif 22", "protein_names_refseq": "UDPG pyrophosphatase; UGPPase; nucleoside diphosphate-linked moiety X motif 22; nudix (nucleoside diphosphate linked moiety X)-type motif 22; nudix motif 22; uridine diphosphate glucose pyrophosphatase NUDT22", "tax_id": 10116, "disease": "", "pathway": " (rno:293703)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pyrophosphatase hydrolyzing the diphosphate bond in the nucleotide-sugars UDP-glucose and UDP-galactose with a preference for the former, yielding glucose 1-phosphate or galactose 1-phosphate and UMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0008768 UDP-sugar diphosphatase activity;GO:0046872 metal ion binding;GO:0052751 GDP-mannose hydrolase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6P9U1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6PDV7-1", "uniprot_id": [ { "id": "RL10_RAT", "url": "https://www.uniprot.org/uniprot/Q6PDV7", "type": "external" } ], "mass": 24604.0, "length": 214, "protein_name": "Large ribosomal subunit protein uL16", "gene_name": "Rpl10", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL16", "refseq_ac": [ { "id": "NP_112362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112362", "type": "external" } ], "gene_names_uniprotkb": "Rpl10", "gene_names_refseq": "Rpl10", "protein_names_uniprotkb": "Large ribosomal subunit protein uL16; 60S ribosomal protein L10; Ribosomal protein L10", "protein_names_refseq": "60S ribosomal protein L10; large ribosomal subunit protein uL16", "tax_id": 10116, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); syndromic X-linked mental retardation 35 (Disease Ontology:DOID:0080241); autistic disorder (Disease Ontology:DOID:12849); spondyloepiphyseal dysplasia congenita (Disease Ontology:DOID:14789); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603)", "pathway": " (rno:81764); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "38843836;8780716", "class_list": "", "function": "Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P45634", "ec_number_list": [], "go_molecular_function": "GO:0045182 translation regulator activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005790 smooth endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0006412 translation;GO:0097421 liver regeneration;GO:1990403 embryonic brain development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6PDV7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QA27-1", "uniprot_id": [ { "id": "TRI44_RAT", "url": "https://www.uniprot.org/uniprot/Q6QA27", "type": "external" } ], "mass": 38086.0, "length": 344, "protein_name": "Tripartite motif-containing protein 44", "gene_name": "Trim44", "organism": "Rat", "refseq_name": "tripartite motif-containing protein 44", "refseq_ac": [ { "id": "NP_001013221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013221", "type": "external" } ], "gene_names_uniprotkb": "Trim44; Dipb", "gene_names_refseq": "Trim44", "protein_names_uniprotkb": "Tripartite motif-containing protein 44; Protein DIPB", "protein_names_refseq": "DIPB protein; tripartite motif protein 44; tripartite motif-containing protein 44", "tax_id": 10116, "disease": "aniridia (Disease Ontology:DOID:12271)", "pathway": " (rno:362172)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "35609523", "class_list": "", "function": "May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (By similarity). Is a negative regulator of PAX6 expression (By similarity)., [UniProtKB, UniProtKB]; Silencing of TRIM44 Inhibits Inflammation and Alleviates Traumatic Brain Injury in Rats by Downregulating TLR4-NF-kappaB Signaling., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0045893 positive regulation of DNA-templated transcription;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6QA27-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6REY9-1", "uniprot_id": [ { "id": "RHG20_RAT", "url": "https://www.uniprot.org/uniprot/Q6REY9", "type": "external" } ], "mass": 131138.0, "length": 1182, "protein_name": "Rho GTPase-activating protein 20", "gene_name": "Arhgap20", "organism": "Rat", "refseq_name": "rho GTPase-activating protein 20 isoform 1", "refseq_ac": [ { "id": "NP_001421259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421259", "type": "external" } ], "gene_names_uniprotkb": "Arhgap20", "gene_names_refseq": "Arhgap20; RARhoGAP", "protein_names_uniprotkb": "Rho GTPase-activating protein 20; RA and RhoGAP domain-containing protein; RARhoGAP; Rho-type GTPase-activating protein 20", "protein_names_refseq": "RA and RhoGAP domain-containing protein; RhoGTPase activating protein; rho GTPase-activating protein 20 isoform 1; rho GTPase-activating protein 20; rho-type GTPase-activating protein 20", "tax_id": 10116, "disease": "", "pathway": " (rno:367085); (R-RNO-8980692); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "15234003;22673903", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state., [UniProtKB]; RARhoGAP expression was found in differentiating male germ cells and in the testis, suggesting that it may be involved in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0035023 regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6REY9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RIA2-1", "uniprot_id": [ { "id": "PAF15_RAT", "url": "https://www.uniprot.org/uniprot/Q6RIA2", "type": "external" } ], "mass": 12006.0, "length": 110, "protein_name": "PCNA-associated factor", "gene_name": "Pclaf", "organism": "Rat", "refseq_name": "PCNA-associated factor", "refseq_ac": [ { "id": "NP_958821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_958821", "type": "external" } ], "gene_names_uniprotkb": "Pclaf; Ns5atp9; Paf", "gene_names_refseq": "Ns5atp9; PAF15; Paf; Pclaf", "protein_names_uniprotkb": "PCNA-associated factor; HCV NS5A-transactivated protein 9 homolog; PAF15; PCNA-associated factor of 15 kDa; PCNA-clamp-associated factor; p15PAF", "protein_names_refseq": "HCV NS5A-transactivated protein 9 homolog; NS5A (hepatitis C virus) transactivated protein 9; PCNA-associated factor of 15 kDa; PCNA-associated factor; p15PAF", "tax_id": 10116, "disease": "", "pathway": " (rno:300795); (R-RNO-5656169)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006974 DNA damage response;GO:0009411 response to UV;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6RIA2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6RVG2-2", "uniprot_id": [ { "id": "S4A8_RAT", "url": "https://www.uniprot.org/uniprot/Q6RVG2", "type": "external" } ], "mass": 122489.0, "length": 1092, "protein_name": "Electroneutral sodium bicarbonate exchanger 1", "gene_name": "Slc4a8", "organism": "Rat", "refseq_name": "electroneutral sodium bicarbonate exchanger 1 isoform 2", "refseq_ac": [ { "id": "NP_001257723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257723", "type": "external" } ], "gene_names_uniprotkb": "Slc4a8; Ndcbe1", "gene_names_refseq": "Slc4a8", "protein_names_uniprotkb": "Electroneutral sodium bicarbonate exchanger 1; Electroneutral Na+-driven Cl-HCO3 exchanger; Solute carrier family 4 member 8; k-NBC3", "protein_names_refseq": "Na-driven Cl-HCO3 exchanger NDCBE1-A; Na-driven Cl-HCO3 exchanger NDCBE1-B; Na-driven Cl-HCO3 exchanger NDCBE1-C; electroneutral Na+-driven Cl-HCO3 exchanger; electroneutral sodium bicarbonate exchanger 1 isoform 2; electroneutral sodium bicarbonate exchanger 1; k-NBC3; solute carrier family 4 (anion exchanger), member 8; solute carrier family 4, sodium bicarbonate cotransporter, member 8", "tax_id": 10116, "disease": "prediabetes syndrome (Disease Ontology:DOID:11716); anemia (Disease Ontology:DOID:2355)", "pathway": " (rno:315311); (R-RNO-425381)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "16916513;17715183;18359573;21195699;22102085;34584093;8189393", "class_list": "", "function": "Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:34584093, PubMed:8189393). Plays a major role in pH regulation in neurons (PubMed:8189393). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Results suggest that Na(+)-driven Cl(-)/HCO(3)(-) exchanger (NCBE) activity is inhibited by protein kinase A and depends on the integrity of the actin cytoskeleton within a multiprotein complex at the plasma membrane., [RefSeq, PubMed]; These findings suggest that NDCBE can regulate glutamatergic transmission throughout the brain, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 18, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1LUB7;Q6RVG1;Q6RVG3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0015081 sodium ion transmembrane transporter activity;GO:0008510 sodium:bicarbonate symporter activity;GO:0015106 bicarbonate transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0097457 hippocampal mossy fiber;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:2000302 positive regulation of synaptic vesicle exocytosis;GO:0042391 regulation of membrane potential;GO:0055085 transmembrane transport;GO:0050804 modulation of chemical synaptic transmission;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q6RVG2-2", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6SLE7-1", "uniprot_id": [ { "id": "SARCO_RAT", "url": "https://www.uniprot.org/uniprot/Q6SLE7", "type": "external" } ], "mass": 3808.0, "length": 31, "protein_name": "Sarcolipin", "gene_name": "Sln", "organism": "Rat", "refseq_name": "sarcolipin", "refseq_ac": [ { "id": "NP_001013265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013265", "type": "external" } ], "gene_names_uniprotkb": "Sln", "gene_names_refseq": "Sln", "protein_names_uniprotkb": "Sarcolipin", "protein_names_refseq": "sarcolipin", "tax_id": 10116, "disease": "", "pathway": " (rno:367086)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15801907;16036219;16566928;19631655", "class_list": "", "function": "Reversibly inhibits the activity of ATP2A1/SERCA1 and ATP2A2/SERCA2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Also inhibits the activity of ATP2A3/SERCA3. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The atrium-specific effect of thyroid hormone may occur in part through the regulation of atrial sarcolipin gene expression., [RefSeq, PubMed]; The expression of SLN and PLB mRNA and protein relative to SERCA1 or SERCA2 was assessed in ventricle, atrium, and skeltal msucle of mouse, rat, rabbit and pig., [RefSeq, PubMed]; We generated right-sided pressure-overload models by monocrotaline administration in Wistar rats. Monocrotaline administration significantly decreased expression of sarcolipin, SERCA2a, & phospholamban mRNAs in right atrium than those in left atrium., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity;GO:1901895 negative regulation of ATPase-coupled calcium transmembrane transporter activity;GO:0051924 regulation of calcium ion transport;GO:0070296 sarcoplasmic reticulum calcium ion transport;GO:1901077 regulation of relaxation of muscle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6SLE7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6T3U3-1", "uniprot_id": [ { "id": "NPCL1_RAT", "url": "https://www.uniprot.org/uniprot/Q6T3U3", "type": "external" } ], "mass": 146415.0, "length": 1331, "protein_name": "NPC1-like intracellular cholesterol transporter 1", "gene_name": "Npc1l1", "organism": "Rat", "refseq_name": "NPC1-like intracellular cholesterol transporter 1 precursor", "refseq_ac": [ { "id": "NP_001002025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002025", "type": "external" } ], "gene_names_uniprotkb": "Npc1l1", "gene_names_refseq": "Npc1l1; SLC66A2", "protein_names_uniprotkb": "NPC1-like intracellular cholesterol transporter 1; Niemann-Pick C1-like protein 1; Npc1l1", "protein_names_refseq": "NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC1-like 1; NPC1-like intracellular cholesterol transporter 1 precursor; Niemann-Pick C1-like protein 1; Niemann-Pick disease, type C1-like 1; solute carrier family 66 member 2", "tax_id": 10116, "disease": "Niemann-Pick disease type C1 (Disease Ontology:DOID:0070113); Niemann-Pick disease (Disease Ontology:DOID:14504)", "pathway": " (rno:432367); (R-RNO-8963678)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "14976318;15777641;15928087;17135346;21844200;25696002;25716431;29393594;29880681", "class_list": "", "function": "Cdc42 controls the cholesterol-regulated transport and localization of NPC1L1, and plays a role in cholesterol absorption., [RefSeq, PubMed]; Decreased mRNA levels of HNF4alpha and SREBP2 in mice could be involved in the reduction in NPC1L1 expression., [RefSeq, PubMed]; Demonstrate that Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter, plays a central role in intestinal VK uptake and modulates the anticoagulant effect of warfarin. In, [RefSeq, PubMed]; NPC1L1 exists as a predominantly cell surface membrane expressed protein, consistent with its proposed role as the putative intestinal sterol transporter, [RefSeq, PubMed]; NPC1L1 protein plays a critical role in the absorption of intestinal cholesterol. NPC1L1 expression is enriched in the small intestine and is in the brush border membrane of enterocytes., [RefSeq, PubMed]; Plays a major role in cholesterol homeostasis (PubMed:17135346). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:17135346). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (PubMed:17135346). Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia (PubMed:15928087). May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (By similarity). May be involved in caveolin trafficking from the plasma membrane (By similarity). Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 11, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 11, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 11, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 18, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0042803 protein homodimerization activity;GO:0015485 cholesterol binding;GO:0031267 small GTPase binding;GO:0008431 vitamin E binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0071501 cellular response to sterol depletion;GO:0042157 lipoprotein metabolic process;GO:0006695 cholesterol biosynthetic process;GO:0030299 intestinal cholesterol absorption;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q6T3U3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VEU1-1", "uniprot_id": [ { "id": "NOB1_RAT", "url": "https://www.uniprot.org/uniprot/Q6VEU1", "type": "external" } ], "mass": 46425.0, "length": 410, "protein_name": "RNA-binding protein NOB1", "gene_name": "Nob1", "organism": "Rat", "refseq_name": "RNA-binding protein NOB1", "refseq_ac": [ { "id": "NP_954517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954517", "type": "external" } ], "gene_names_uniprotkb": "Nob1; Nob1p", "gene_names_refseq": "Nob1p; Nob1", "protein_names_uniprotkb": "RNA-binding protein NOB1; 3.1.-.-", "protein_names_refseq": "NIN1/PSMD8 binding protein 1 homolog; RNA-binding protein NOB1; nin one binding protein", "tax_id": 10116, "disease": "", "pathway": " (rno:291996); (R-RNO-6791226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21219967;29393594", "class_list": "", "function": "May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; May play a role in mRNA degradation. Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits., [UniProtKB, UniProtKB, UniProtKB]; Nob1 may play an important role in auditory function following acoustic trauma., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JN09", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0007601 visual perception;GO:0030490 maturation of SSU-rRNA;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6VEU1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76HP2-1", "uniprot_id": [ { "id": "T132D_RAT", "url": "https://www.uniprot.org/uniprot/Q76HP2", "type": "external" } ], "mass": 121139.0, "length": 1097, "protein_name": "Transmembrane protein 132D", "gene_name": "Tmem132d", "organism": "Rat", "refseq_name": "transmembrane protein 132D precursor", "refseq_ac": [ { "id": "NP_942022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942022", "type": "external" } ], "gene_names_uniprotkb": "Tmem132d; Molt", "gene_names_refseq": "MOLT; Tmem132d", "protein_names_uniprotkb": "Transmembrane protein 132D; Mature OL transmembrane protein; Mature oligodendrocytes transmembrane protein", "protein_names_refseq": "mature OL transmembrane protein; mature oligodendrocyte transmembrane protein; mature oligodendrocytes transmembrane protein; transmembrane protein 132D precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:288750)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12966072", "class_list": "", "function": "Regulates neuronal morphology via inhibition of the WAVE regulatory complex (WCR), a complex that controls F-actin cytoskeletal dynamics., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1M5W0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q76HP2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7M730-1", "uniprot_id": [ { "id": "SCN4B_RAT", "url": "https://www.uniprot.org/uniprot/Q7M730", "type": "external" } ], "mass": 25247.0, "length": 228, "protein_name": "Sodium channel regulatory subunit beta-4", "gene_name": "Scn4b", "organism": "Rat", "refseq_name": "sodium channel regulatory subunit beta-4 precursor", "refseq_ac": [ { "id": "NP_001008880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008880", "type": "external" } ], "gene_names_uniprotkb": "Scn4b", "gene_names_refseq": "Scn4b", "protein_names_uniprotkb": "Sodium channel regulatory subunit beta-4", "protein_names_refseq": "sodium channel accessory subunit; sodium channel beta 4 subunit; sodium channel regulatory subunit beta-4 precursor; sodium channel regulatory subunit beta-4; sodium channel subunit beta-4; sodium channel, type 4, beta subunit; sodium channel, type IV, beta; sodium channel, voltage-gated, type IV, beta subunit", "tax_id": 10116, "disease": "long QT syndrome 10 (Disease Ontology:DOID:0110651)", "pathway": " (rno:315611)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12930796;16432696;21099342;24090084;26408173;26785322;26894959;30699332", "class_list": "", "function": "Anthopleurin elicited opposing effects on the gating mode, kinetics and charge immobilized during open- versus closed-state fast inactivation of Nav1.4 channels., [RefSeq, PubMed]; Data suggest that modulation of the sodium current by the expression of the highly sialylated beta1-subunit may alter the channel gating by increasing the density of surface negative charges in the vicinity of the sodium channel voltage sensing machinery., [RefSeq, PubMed]; NaVbeta4 may represent a more specific target for pain conditions that depend on myelinated neurons expressing NaV1.6, [RefSeq, PubMed]; Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:12930796). Modulates the activity of SCN1A/Nav1.1 (By similarity). Modulates the activity of SCN2A/Nav1.2 (PubMed:12930796)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Study found that knockdown of either NaV1.6 or NaVbeta4 reduced pain behaviors and sensory neuron hyperexcitability in the chronic compression dorsal rook ganglia model of low back pain., [RefSeq, PubMed]; This study identified Navbeta4 as an important regulator of excitability in sensory neurons. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 2, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q80Z84", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014704 intercalated disc;GO:0001518 voltage-gated sodium channel complex;GO:0016020 membrane", "go_biological_process": "GO:0019228 neuronal action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:0060048 cardiac muscle contraction;GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization;GO:0061337 cardiac conduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7M730-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7TP17-1", "uniprot_id": [ { "id": "U2AF4_RAT", "url": "https://www.uniprot.org/uniprot/Q7TP17", "type": "external" } ], "mass": 25836.0, "length": 220, "protein_name": "Splicing factor U2AF 26 kDa subunit", "gene_name": "U2af1l4", "organism": "Rat", "refseq_name": "splicing factor U2AF 26 kDa subunit", "refseq_ac": [ { "id": "NP_001008775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008775", "type": "external" } ], "gene_names_uniprotkb": "U2af1l4; Cb2-806; Cb2-807", "gene_names_refseq": "U2af1l4", "protein_names_uniprotkb": "Splicing factor U2AF 26 kDa subunit; Liver regeneration-related protein LRRG157/LRRG158; U2 auxiliary factor 26; U2 small nuclear RNA auxiliary factor 1-like protein 4; U2AF1-like 4", "protein_names_refseq": "Cb2-807; U2 auxiliary factor 26; U2 small nuclear RNA auxiliary factor 1-like protein 4; U2AF1-like 4; liver regeneration-related protein LRRG157/LRRG158; splicing factor U2AF 26 kDa subunit", "tax_id": 10116, "disease": "", "pathway": " (rno:361542); (R-RNO-159236); (R-RNO-9770562)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7TP18", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030628 pre-mRNA 3'-splice site binding;GO:0003677 DNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0089701 U2AF complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q7TP17-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80WK7-1", "uniprot_id": [ { "id": "S29A3_RAT", "url": "https://www.uniprot.org/uniprot/Q80WK7", "type": "external" } ], "mass": 51677.0, "length": 475, "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "Slc29a3", "organism": "Rat", "refseq_name": "equilibrative nucleoside transporter 3", "refseq_ac": [ { "id": "NP_853670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853670", "type": "external" } ], "gene_names_uniprotkb": "Slc29a3; Ent3", "gene_names_refseq": "Ent3; Slc29a3; rENT3", "protein_names_uniprotkb": "Equilibrative nucleoside transporter 3; Solute carrier family 29 member 3; rENT3", "protein_names_refseq": "equilibrative nucleoside transporter 3; solute carrier family 29 (equilibrative nucleoside transporter), member 3; solute carrier family 29 (nucleoside transporters), member 3", "tax_id": 10116, "disease": "histiocytosis-lymphadenopathy plus syndrome (Disease Ontology:DOID:0111278)", "pathway": " (rno:353307); (R-RNO-83936); (R-RNO-9755088)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15701636;22673903", "class_list": "", "function": "Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes. Functions as a non-electrogenic Na(+)-independent transporter. Transport activity is pH-dependent and enhanced under acidic conditions, consistent with localization to acidic intracellular compartments. Protons are not cotransported but likely modulate transport by altering the ionization state of the transporter which dictates its conformation, thereby regulating substrate permeability. May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate nucleic acid salvage pathways. Transports nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine), deoxynucleosides (deoxyadenosine, deoxycytidine), purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil). Also capable of transporting monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine, as well as ATP (By similarity). Mediates nucleoside export from lysosomes in macrophages, thereby regulating macrophage function and number (By similarity). Also functions as a lysosomal urate exporter, contributing to intracellular urate disposal. Regulates inflammasome activation via dual roles in urate and adenosine transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6AZ86", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015205 nucleobase transmembrane transporter activity;GO:0015212 cytidine transmembrane transporter activity;GO:0015213 uridine transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0015851 nucleobase transport;GO:0015861 cytidine transport;GO:0015858 nucleoside transport;GO:0015862 uridine transmembrane transport;GO:0015872 dopamine transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q80WK7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q80ZG1-1", "uniprot_id": [ { "id": "RIC8A_RAT", "url": "https://www.uniprot.org/uniprot/Q80ZG1", "type": "external" } ], "mass": 59827.0, "length": 530, "protein_name": "Chaperone Ric-8A", "gene_name": "Ric8a", "organism": "Rat", "refseq_name": "chaperone Ric-8A", "refseq_ac": [ { "id": "NP_001093990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093990", "type": "external" } ], "gene_names_uniprotkb": "Ric8a", "gene_names_refseq": "Ric-8A; Ric8a; Ric8", "protein_names_uniprotkb": "Chaperone Ric-8A; Synembryn-A", "protein_names_refseq": "chaperone Ric-8A; heterotrimeric G protein guanine nucleotide exchange factor Ric-8A; resistance to inhibitors of cholinesterase 8 homolog; resistance to inhibitors of cholinesterase 8A-like protein; resistance to inhibitors of cholinesterase 8A; synembryn-A", "tax_id": 10116, "disease": "", "pathway": " (rno:293614)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12509430;16275912;18541531;21158412;27558716;28008853;29393594;29844055;31155309;32103024;32126208", "class_list": "", "function": "Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (PubMed:29844055, PubMed:32103024, PubMed:32126208). Does not fold G(s) G-alpha proteins GNAS nor GNAL (PubMed:29844055). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (PubMed:12509430, PubMed:16275912, PubMed:29844055, PubMed:31155309, PubMed:32103024). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (PubMed:12509430, PubMed:16275912). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; In contrast to G protein-coupled receptors, Ric-8A interacts with Switches I and II of Galpha and possibly at the Galpha domain interface. Publication Status: Online-Only, [RefSeq, PubMed]; Induction of Galphai1 structural heterogeneity by Ric-8A provides a mechanism for nucleotide release, [RefSeq, PubMed]; Ric-8A has a role in catalyzing guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3, [RefSeq, PubMed]; Structure, function, and dynamics of the Galpha binding domain of Ric-8A have been reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 22, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B1H241", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0016020 membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008542 visual learning;GO:0042074 cell migration involved in gastrulation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q80ZG1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q810I1-1", "uniprot_id": [ { "id": "TRI50_RAT", "url": "https://www.uniprot.org/uniprot/Q810I1", "type": "external" } ], "mass": 54719.0, "length": 483, "protein_name": "E3 ubiquitin-protein ligase TRIM50", "gene_name": "Trim50", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM50 isoform 1", "refseq_ac": [ { "id": "NP_851594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851594", "type": "external" } ], "gene_names_uniprotkb": "Trim50", "gene_names_refseq": "Trim50", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM50; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM50; Tripartite motif-containing protein 50", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM50 isoform 1; E3 ubiquitin-protein ligase TRIM50; RING-type E3 ubiquitin transferase TRIM50; tripartite motif protein 50; tripartite motif-containing protein 50", "tax_id": 10116, "disease": "", "pathway": " (rno:288596); (R-RNO-983168)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22872646", "class_list": "", "function": "E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Also interacts with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. Also promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity)., [UniProtKB, UniProtKB]; TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016235 aggresome", "go_biological_process": "GO:0045087 innate immune response;GO:0070201 regulation of establishment of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q810I1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q811R2-1", "uniprot_id": [ { "id": "PRGC2_RAT", "url": "https://www.uniprot.org/uniprot/Q811R2", "type": "external" } ], "mass": 111589.0, "length": 1010, "protein_name": "Peroxisome proliferator-activated receptor gamma coactivator 1-beta", "gene_name": "Ppargc1b", "organism": "Rat", "refseq_name": "peroxisome proliferator-activated receptor gamma coactivator 1-beta", "refseq_ac": [ { "id": "NP_788264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788264", "type": "external" } ], "gene_names_uniprotkb": "Ppargc1b; Perc; Pgc1b; Pgc1; Ppargc1", "gene_names_refseq": "PGC1beta; Perc; Ppargc1b", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor gamma coactivator 1-beta; PGC-1-beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta", "protein_names_refseq": "PGC-1-beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:291567); (R-RNO-9841922)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12678921;12807885;27631411;30635067", "class_list": "", "function": "Abeta increases the expression of mTOR and p-mTOR at the site of Ser2448, and the stimulation of Abeta is likely to depend on sirtuin 1, PPARgamma, and PGC-1beta pathway in regulating mTOR expression., [RefSeq, PubMed]; MiR-30c/PGC-1beta protects against diabetic cardiomyopathy via PPARalpha signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Also induces the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0030331 nuclear estrogen receptor binding;GO:0050682 AF-2 domain binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007584 response to nutrient;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q811R2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CH01-1", "uniprot_id": [ { "id": "TKN4_RAT", "url": "https://www.uniprot.org/uniprot/Q8CH01", "type": "external" } ], "mass": 18751.0, "length": 170, "protein_name": "Tachykinin-4", "gene_name": "Tac4", "organism": "Rat", "refseq_name": "tachykinin-4 preproprotein", "refseq_ac": [ { "id": "NP_758831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_758831", "type": "external" } ], "gene_names_uniprotkb": "Tac4", "gene_names_refseq": "Ppt-c; Tac4", "protein_names_uniprotkb": "Tachykinin-4; HK-I; HK1; Hemokinin-1; Hemokinin-I; PPT-C; Preprotachykinin-C", "protein_names_refseq": "preprotachykinin-C; tachykinin 4 (hemokinin); tachykinin-4 preproprotein; tachykinin-4", "tax_id": 10116, "disease": "", "pathway": " (rno:282829)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "11786503;12044836;12383518;16102736;17628523;20176398;22384199;22554585", "class_list": "", "function": "HKs emerge as pivotal endogenous regulators of angiogenesis through neurokinin-1 receptor, [RefSeq, PubMed]; Hemokinin-1 gene expression is upregulated in microglia activated by lipopolysaccharide through NF-kappaB and p38 MAPK signaling pathways, [RefSeq, PubMed]; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and proliferation. Lowers systemic arterial pressure following intravenous injection. Induces interferon-gamma production and may play a role in the inflammatory response. Shows potent affinity and specificity for the NK-1 receptor., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; These findings indicate that three amino acids, Ser, Thr and Arg at the 2nd, 4th and 5th positions of HK-1, respectively, regulate the induction of thermal hyperalgesia by HK-1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031835 substance P receptor binding;GO:0031837 substance K receptor binding;GO:0005102 signaling receptor binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:1904057 negative regulation of sensory perception of pain;GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0051930 regulation of sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8CH01-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CHN3-1", "uniprot_id": [ { "id": "WFDC2_RAT", "url": "https://www.uniprot.org/uniprot/Q8CHN3", "type": "external" } ], "mass": 17448.0, "length": 168, "protein_name": "WAP four-disulfide core domain protein 2", "gene_name": "Wfdc2", "organism": "Rat", "refseq_name": "WAP four-disulfide core domain protein 2 precursor", "refseq_ac": [ { "id": "NP_775132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775132", "type": "external" } ], "gene_names_uniprotkb": "Wfdc2", "gene_names_refseq": "Wfdc2; re4", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 2; Epididymal secretory protein 4; RE4", "protein_names_refseq": "WAP four-disulfide core domain protein 2 precursor; WAP four-disulfide core domain protein 2; epididymal secretory protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:286888)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "33903172", "class_list": "", "function": "HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression., [RefSeq, PubMed]; Plays a critical role in lung development (By similarity). Required for terminal differentiation of bronchiole club cells (By similarity). Required for development of airway barrier mechanisms, such as lamellar body formation in type II alveolar epithelial cells and cilia formation on ciliated epithelial cells following initiation of respiration at birth (By similarity). Required for type I alveolar epithelial cell and vascular endothelial development in the lungs, thereby mediating blood-air barrier exchange (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8CHN1", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0019828 aspartic-type endopeptidase inhibitor activity;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:1901248 positive regulation of lung ciliated cell differentiation;GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0060426 lung vasculature development;GO:0060486 club cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8CHN3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3F3-1", "uniprot_id": [ { "id": "PP14B_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3F3", "type": "external" } ], "mass": 15957.0, "length": 147, "protein_name": "Protein phosphatase 1 regulatory subunit 14B", "gene_name": "Ppp1r14bl1; Ppp1r14b", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 14B", "refseq_ac": [ { "id": "NP_742042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742042", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r14bl1; Ppp1r14b; Phi1; Ppp1r14b-ps2; Ppp1r14b", "gene_names_refseq": "PHI-1; Ppp1r14b", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 14B; PHI-1; Phosphatase holoenzyme inhibitor 1; Ubiquitous PKC-potentiated PP1 inhibitor", "protein_names_refseq": "phosphatase holoenzyme inhibitor 1; protein phosphatase 1 regulatory subunit 14B; protein phosphatase 1, regulatory (inhibitor) 5 subunit 14B; ubiquitous PKC-potentiated PP1 inhibitor", "tax_id": 10116, "disease": "", "pathway": " (rno:259225)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12144526;12974676;15522888", "class_list": "", "function": "ILK may activate smooth-muscle contraction both directly, via phosphorylation of myosin, and indirectly, via phosphorylation and activation of CPI-17 and PHI-1, leading to inhibition of myosin light-chain phosphatase., [RefSeq, PubMed]; Inhibitor of PPP1CA., [UniProtKB, UniProtKB]; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity)., [UniProtKB]; PHI-1 participates in regulatory events at the trailing edge of migrating cells and modulates retraction of endothelial and epithelial cells, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0019888 protein phosphatase regulator activity;GO:0019212 phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K3F3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8K3F4-1", "uniprot_id": [ { "id": "PP14D_RAT", "url": "https://www.uniprot.org/uniprot/Q8K3F4", "type": "external" } ], "mass": 16867.0, "length": 146, "protein_name": "Protein phosphatase 1 regulatory subunit 14D", "gene_name": "Ppp1r14d", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 14D", "refseq_ac": [ { "id": "NP_742008", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742008", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r14d; Gbpi", "gene_names_refseq": "Gbpi; Ppp1r14d", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 14D; GBPI-1; Gastrointestinal and brain-specific PP1-inhibitory protein 1", "protein_names_refseq": "GBPI-1; gastrointestinal and brain-specific PP1-inhibitory protein 1; gastrointestinal- and brain-specific PKC-activated PP1 inhibitor; protein phosphatase 1 regulatory subunit 14D", "tax_id": 10116, "disease": "", "pathway": " (rno:259226)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12974676;17537548;21112318", "class_list": "", "function": "A gastrointestinal- and brain-specific PP1 inhibitory protein (GBPI-1)is activated by PKC phosphorylation. A longer GBPI-2 splice variant mRNA is found in testis., [RefSeq, PubMed]; Brain PPP1R14D is upregulated in alloxan diabetes. It inhibits the function of PP1, switches-on glycogen breakdown and switches-off glycogen synthesis due to lack of insulin., [RefSeq, PubMed]; Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; PP-1 activity due to a decrease in cyclic GMP-PKG modulation plays a role for the age-related reduction of alpha(2/3)-Na,K-ATPase activity in rat cerebellum., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8K3F4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R414-1", "uniprot_id": [ { "id": "PROK1_RAT", "url": "https://www.uniprot.org/uniprot/Q8R414", "type": "external" } ], "mass": 11643.0, "length": 105, "protein_name": "Prokineticin-1", "gene_name": "Prok1", "organism": "Rat", "refseq_name": "prokineticin-1 precursor", "refseq_ac": [ { "id": "NP_620206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620206", "type": "external" } ], "gene_names_uniprotkb": "Prok1", "gene_names_refseq": "Prok1", "protein_names_uniprotkb": "Prokineticin-1; EG-VEGF; Endocrine-gland-derived vascular endothelial growth factor", "protein_names_refseq": "EG-VEGF; endocrine-gland-derived vascular endothelial growth factor; prokineticin-1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:192205); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12054613;31322191", "class_list": "", "function": "Polycystic ovary syndrome development promoted by PROK1 overexpression is inhibited by miR-28-5p via the PI3K/AKT/mTOR signaling pathway., [RefSeq, PubMed]; Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051781 positive regulation of cell division;GO:0045765 regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8R414-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R4E1-1", "uniprot_id": [ { "id": "TIP_RAT", "url": "https://www.uniprot.org/uniprot/Q8R4E1", "type": "external" } ], "mass": 67337.0, "length": 610, "protein_name": "T-cell immunomodulatory protein", "gene_name": "Itfg1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Itfg1; Cda08; Lnkn-1; Tip", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell immunomodulatory protein; CDA08-like protein; Integrin-alpha FG-GAP repeat-containing protein 1; Linkin; Protein TIP", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "21454685;24090084;38843836", "class_list": "", "function": "Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity)., [UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 2, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 3, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8R4E1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8VIJ4-1", "uniprot_id": [ { "id": "NR2C1_RAT", "url": "https://www.uniprot.org/uniprot/Q8VIJ4", "type": "external" } ], "mass": 65528.0, "length": 590, "protein_name": "Nuclear receptor subfamily 2 group C member 1", "gene_name": "Nr2c1", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 2 group C member 1", "refseq_ac": [ { "id": "NP_665723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665723", "type": "external" } ], "gene_names_uniprotkb": "Nr2c1; Tr2", "gene_names_refseq": "Nr2c1; Psg4; TR2-11; Tr2", "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor TR2; Testicular receptor 2", "protein_names_refseq": "nuclear receptor subfamily 2 group C member 1; nuclear receptor subfamily 2, group H, member 1; orphan nuclear receptor TR2; orphan receptor, TR2-11; pregnancy specific beta-1-glycoprotein 4; testicular receptor 2", "tax_id": 10116, "disease": "developmental and epileptic encephalopathy 33 (Disease Ontology:DOID:0080463); dilated cardiomyopathy (Disease Ontology:DOID:12930); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:252924); (R-RNO-383280)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016605 PML body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8VIJ4-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXN1-1", "uniprot_id": [ { "id": "LEF1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXN1", "type": "external" } ], "mass": 44023.0, "length": 397, "protein_name": "Lymphoid enhancer-binding factor 1", "gene_name": "Lef1", "organism": "Rat", "refseq_name": "lymphoid enhancer-binding factor 1", "refseq_ac": [ { "id": "NP_569113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569113", "type": "external" } ], "gene_names_uniprotkb": "Lef1", "gene_names_refseq": "Lef1", "protein_names_uniprotkb": "Lymphoid enhancer-binding factor 1; LEF-1", "protein_names_refseq": "LEF-1; lymphoid enhancer-binding factor 1", "tax_id": 10116, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); prostate cancer (Disease Ontology:DOID:10283); anxiety disorder (Disease Ontology:DOID:2030); ovarian cancer (Disease Ontology:DOID:2394); papillary thyroid carcinoma (Disease Ontology:DOID:3969); prostate carcinoma in situ (Disease Ontology:DOID:8634); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:161452); (R-RNO-201722); (R-RNO-3769402); (R-RNO-4086398); (R-RNO-4641265); (R-RNO-8951430); (R-RNO-9825892)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "10824856;33407665;33422572", "class_list": "", "function": "Knockdown of long non-coding RNA LEF1-AS1 attenuates apoptosis and inflammatory injury of microglia cells following spinal cord injury. Publication Status: Online-Only, [RefSeq, PubMed]; Oxytocin Facilitates Dentinogenesis of Rat Dental Pulp Cells., [RefSeq, PubMed]; Transcription factor that binds DNA in a sequence-specific manner (By similarity). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function (By similarity). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. May play a role in hair cell differentiation and follicle morphogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0045063 T-helper 1 cell differentiation;GO:0048341 paraxial mesoderm formation;GO:0021861 forebrain radial glial cell differentiation;GO:1901331 positive regulation of odontoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QXN1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06882-1", "uniprot_id": [ { "id": "THYG_RAT", "url": "https://www.uniprot.org/uniprot/P06882", "type": "external" } ], "mass": 304645.0, "length": 2768, "protein_name": "Thyroglobulin", "gene_name": "Tg", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Tg", "gene_names_refseq": "", "protein_names_uniprotkb": "Thyroglobulin; Tg", "protein_names_refseq": "", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); isolated growth hormone deficiency (Disease Ontology:DOID:0060870); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); thyroid dyshormonogenesis 3 (Disease Ontology:DOID:0112187); goiter (Disease Ontology:DOID:12176); Graves' disease (Disease Ontology:DOID:12361); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); hypothyroidism (Disease Ontology:DOID:1459); autoimmune thyroiditis (Disease Ontology:DOID:7188)", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "11089535;2325666;3455768;3838512;7927539;9135553", "class_list": "", "function": "Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity). One dimer produces 7 thyroid hormone molecules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 23, "predicted_n_glycosites": 22, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 23, "binding_glycan_count": 0, "secondary_ac_list": "Q9JKY6;Q9JM94", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0044877 protein-containing complex binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex;GO:0005576 extracellular region", "go_biological_process": "GO:0030878 thyroid gland development;GO:0071412 cellular response to genistein;GO:0032496 response to lipopolysaccharide;GO:0009268 response to pH;GO:0042446 hormone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P06882-1", "record_type": "protein", "filter_code": "0000000.0000110.001000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PP0-1", "uniprot_id": [ { "id": "CCN4_RAT", "url": "https://www.uniprot.org/uniprot/Q99PP0", "type": "external" } ], "mass": 40614.0, "length": 367, "protein_name": "CCN family member 4", "gene_name": "Ccn4", "organism": "Rat", "refseq_name": "CCN family member 4 precursor", "refseq_ac": [ { "id": "NP_113904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113904", "type": "external" } ], "gene_names_uniprotkb": "Ccn4; Elm1; Wisp1", "gene_names_refseq": "Ccn4; Wisp1", "protein_names_uniprotkb": "CCN family member 4; ELM-1; WISP-1; WNT1-inducible-signaling pathway protein 1", "protein_names_refseq": "CCN family member 4 precursor; CCN family member 4; ELM-1; WISP-1; WNT1 inducible signaling pathway protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:65154)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11031104;17616748;26627308;30556898", "class_list": "", "function": "Downstream regulator in the Wnt/Frizzled-signaling pathway (By similarity). Associated with cell survival. Adheres to skin and melanoma fibroblasts (By similarity). In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan (By similarity)., [UniProtKB]; Thymosin beta4 targets Wnt/WISP-1 signaling to protect against Ang II-induced cardiomyocyte growth., [RefSeq, PubMed]; WISP-1 stimulates cardiomyocyte hypertrophy, fibroblast proliferation, and ECM expression in vitro. These results suggest that WISP-1 may play a critical role in post-myocardial infarction remodeling., [RefSeq, PubMed]; WISP1 gene silencing suppresses the activation of the wnt/beta-catenin signaling pathway., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q9WUW4", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0042593 glucose homeostasis;GO:0045597 positive regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q99PP0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35476-1", "uniprot_id": [ { "id": "OPSG_RAT", "url": "https://www.uniprot.org/uniprot/O35476", "type": "external" } ], "mass": 40200.0, "length": 359, "protein_name": "Medium-wave-sensitive opsin 1", "gene_name": "Opn1mw", "organism": "Rat", "refseq_name": "medium-wave-sensitive opsin 1", "refseq_ac": [ { "id": "NP_446000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446000", "type": "external" } ], "gene_names_uniprotkb": "Opn1mw; Gcp", "gene_names_refseq": "Opn1mw", "protein_names_uniprotkb": "Medium-wave-sensitive opsin 1; Green cone photoreceptor pigment; Green-sensitive opsin; Medium wavelength-sensitive cone opsin", "protein_names_refseq": "green cone photoreceptor pigment; green-sensitive opsin; medium wavelength-sensitive cone opsin; medium-wave-sensitive opsin 1; opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan), green opsin", "tax_id": 10116, "disease": "blue cone monochromacy (Disease Ontology:DOID:0050679); red-green color blindness (Disease Ontology:DOID:13909); red color blindness (Disease Ontology:DOID:13910)", "pathway": " (rno:89810); (R-RNO-2187335); (R-RNO-418594); (R-RNO-419771)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "6233288;9580985;9751808", "class_list": "", "function": "G protein-coupled photoreceptor that selectively activates G(i) proteins in response to medium-wavelength (green) light, thereby decreasing intracellular cAMP levels. Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade. Mediates visual perception of green light in cone photoreceptor cells., [UniProtKB, UniProtKB]; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008020 G protein-coupled photoreceptor activity;GO:0009881 photoreceptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment;GO:0016020 membrane", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0032467 positive regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O35476-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJK4-1", "uniprot_id": [ { "id": "PEX3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJK4", "type": "external" } ], "mass": 42210.0, "length": 372, "protein_name": "Peroxisomal biogenesis factor 3", "gene_name": "Pex3", "organism": "Rat", "refseq_name": "peroxisomal biogenesis factor 3", "refseq_ac": [ { "id": "NP_112640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112640", "type": "external" } ], "gene_names_uniprotkb": "Pex3", "gene_names_refseq": "Pex3", "protein_names_uniprotkb": "Peroxisomal biogenesis factor 3; Peroxin-3; Peroxisomal assembly protein PEX3", "protein_names_refseq": "peroxin-3; peroxisomal assembly protein PEX3; peroxisomal biogenesis factor 3", "tax_id": 10116, "disease": "peroxisome biogenesis disorder 10A (Disease Ontology:DOID:0080484); Peroxisome biogenesis disorder 10B (Disease Ontology:DOID:0081440); Zellweger syndrome (Disease Ontology:DOID:905)", "pathway": " (rno:83519); (R-RNO-1369062); (R-RNO-9603798)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10527525;10848631;29393594", "class_list": "", "function": "Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007031 peroxisome organization;GO:0016557 peroxisome membrane biogenesis;GO:0045046 protein import into peroxisome membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JJK4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4L9P7-1", "uniprot_id": [ { "id": "PDS5A_RAT", "url": "https://www.uniprot.org/uniprot/A4L9P7", "type": "external" } ], "mass": 150286.0, "length": 1333, "protein_name": "Sister chromatid cohesion protein PDS5 homolog A", "gene_name": "Pds5a", "organism": "Rat", "refseq_name": "sister chromatid cohesion protein PDS5 homolog A", "refseq_ac": [ { "id": "NP_001077093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077093", "type": "external" } ], "gene_names_uniprotkb": "Pds5a", "gene_names_refseq": "Pds5a; RGD1307094; Scc-112", "protein_names_uniprotkb": "Sister chromatid cohesion protein PDS5 homolog A", "protein_names_refseq": "PDS5, regulator of cohesion maintenance, homolog A; sister chromatid cohesion protein PDS5 homolog A", "tax_id": 10116, "disease": "Cornelia de Lange syndrome (Disease Ontology:DOID:11725)", "pathway": " (rno:305343); (R-RNO-2467813); (R-RNO-2468052); (R-RNO-2470946); (R-RNO-2500257)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "21069257;22673903", "class_list": "", "function": "Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells., [RefSeq, PubMed]; Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140670 cohesin unloader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0051301 cell division;GO:0003007 heart morphogenesis;GO:0009952 anterior/posterior pattern specification;GO:0060021 roof of mouth development;GO:0001656 metanephros development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A4L9P7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99P74-1", "uniprot_id": [ { "id": "RB27B_RAT", "url": "https://www.uniprot.org/uniprot/Q99P74", "type": "external" } ], "mass": 24620.0, "length": 218, "protein_name": "Ras-related protein Rab-27B", "gene_name": "Rab27b", "organism": "Rat", "refseq_name": "ras-related protein Rab-27B", "refseq_ac": [ { "id": "NP_445911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445911", "type": "external" } ], "gene_names_uniprotkb": "Rab27b", "gene_names_refseq": "Rab27b", "protein_names_uniprotkb": "Ras-related protein Rab-27B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-27B", "tax_id": 10116, "disease": "platelet storage pool deficiency (Disease Ontology:DOID:2223)", "pathway": " (rno:84590); (R-RNO-114608); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "15039459;15451418;21775604;22157766;27325508;29167152", "class_list": "", "function": "Cyt b(558) depends on clathrin for internalization, and in activated macrophages NADPH oxidase occupies a Rab27A/B-regulated secretory compartment, [RefSeq, PubMed]; RAB27B regulates discoidal- and/or fusiform-shaped vesicle exocytosis in bladder umbrella cells., [RefSeq, PubMed]; The Rab27B-Slac2-c complex is an important constituent of secretory granule exocytosis in parotid acinar cells, [RefSeq, PubMed]; The data of this study suggested that Rab27b is involved in myelin biogenesis by regulating PLP transport from late endosomes/lysosomes to the cell membrane in oligodendrocytes., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB27B regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]; These results demonstrate that Rab27b is present on ZGs and plays an important role in regulating acinar exocytosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0016324 apical plasma membrane;GO:0042470 melanosome;GO:0005770 late endosome", "go_biological_process": "GO:0071985 multivesicular body sorting pathway;GO:0099641 anterograde axonal protein transport;GO:0006887 exocytosis;GO:0045921 positive regulation of exocytosis;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99P74-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25094-1", "uniprot_id": [ { "id": "PMP22_RAT", "url": "https://www.uniprot.org/uniprot/P25094", "type": "external" } ], "mass": 17946.0, "length": 160, "protein_name": "Peripheral myelin protein 22", "gene_name": "Pmp22", "organism": "Rat", "refseq_name": "peripheral myelin protein 22", "refseq_ac": [ { "id": "NP_001416879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001416879", "type": "external" } ], "gene_names_uniprotkb": "Pmp22; Cd25; Pmp-22", "gene_names_refseq": "Gas-3; Pmp22", "protein_names_uniprotkb": "Peripheral myelin protein 22; PMP-22; Protein CD25; SAG; SR13 myelin protein; Schwann cell membrane glycoprotein", "protein_names_refseq": "PMP-22; SAG; SR13 myelin protein; peripheral myelin protein 22; schwann cell membrane glycoprotein", "tax_id": 10116, "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); hereditary neuropathy with liability to pressure palsies (Disease Ontology:DOID:0060843); Charcot-Marie-Tooth disease type 1A (Disease Ontology:DOID:0110148); Charcot-Marie-Tooth disease type 1E (Disease Ontology:DOID:0110153); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); sciatic neuropathy (Disease Ontology:DOID:11446); Guillain-Barre syndrome (Disease Ontology:DOID:12842)", "pathway": " (rno:24660)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1287719;1376775;1714591;1935894;29771329;33883545;34837628", "class_list": "", "function": "AAV2/9-mediated silencing of PMP22 prevents the development of pathological features in a rat model of Charcot-Marie-Tooth disease 1 A. Publication Status: Online-Only, [RefSeq, PubMed]; Dysregulated miR-29a-3p/PMP22 Modulates Schwann Cell Proliferation and Migration During Peripheral Nerve Regeneration., [RefSeq, PubMed]; Might be involved in growth regulation, and in myelinization in the peripheral nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our data show a significant decrease in Pmp22 transcript expression using allele-specific internal controls. Moreover, the P2 promoter of the Pmp22 gene, which is used in other cell types, is affected, but we find that the Schwann cell-specific P1 promoter is disproportionately more sensitive to loss of the super-enhancer., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003774 cytoskeletal motor activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0031579 membrane raft organization;GO:0060005 vestibular reflex;GO:0048936 peripheral nervous system neuron axonogenesis;GO:2001233 regulation of apoptotic signaling pathway;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25094-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4F7E9-1", "uniprot_id": [ { "id": "ZNF76_RAT", "url": "https://www.uniprot.org/uniprot/B4F7E9", "type": "external" } ], "mass": 61647.0, "length": 568, "protein_name": "Zinc finger protein 76", "gene_name": "Zfp523; Znf76", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Zfp523; Znf76; Zfp523", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger protein 76; Zinc finger protein 523", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:361809)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that regulates expression of genes transcribed by both RNA polymerases II and III. Specifically recognizes and binds the Staf-binding site (SBS), a consensus DNA-binding motif present in many promoters. Able to activate expression of small nuclear RNA (snRNA) transcribed by RNA polymerases II and III. Also regulates expression of mRNAs and acts as a DNA-binding transcription repressor that inhibits the activity of the TATA-binding protein (TBP)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B4F7E9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C6C0-1", "uniprot_id": [ { "id": "SPKAP_RAT", "url": "https://www.uniprot.org/uniprot/P0C6C0", "type": "external" } ], "mass": 184451.0, "length": 1683, "protein_name": "A-kinase anchor protein SPHKAP", "gene_name": "Sphkap", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sphkap; Skip", "gene_names_refseq": "", "protein_names_uniprotkb": "A-kinase anchor protein SPHKAP; SPHK1-interactor and AKAP domain-containing protein; Sphingosine kinase type 1-interacting protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "16739995;22673903", "class_list": "", "function": "Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030018 Z disc", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C6C0-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXL7-1", "uniprot_id": [ { "id": "NDK7_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXL7", "type": "external" } ], "mass": 44510.0, "length": 395, "protein_name": "Nucleoside diphosphate kinase 7", "gene_name": "Nme7", "organism": "Rat", "refseq_name": "nucleoside diphosphate kinase 7", "refseq_ac": [ { "id": "NP_612541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612541", "type": "external" } ], "gene_names_uniprotkb": "Nme7", "gene_names_refseq": "NDK7; Nm23-r7; Nme7; nm23-H7", "protein_names_uniprotkb": "Nucleoside diphosphate kinase 7; 2.7.11.1; 3.1.11.-; NDK7; NDP kinase 7; NM23-R7; Putative 3'-5'-DNA exonuclease NDK7; Serine protein kinase NME7", "protein_names_refseq": "3'-5' exonuclease NME7; NDK 7; NDP kinase 7; NDP kinase homolog 7; non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase); nucleoside diphosphate kinase 7; nucleoside diphosphate kinase homolog 7; protein kinase NME7; putative 3'-5'-DNA exonuclease NDK7; serine protein kinase NME7", "tax_id": 10116, "disease": "hydrocephalus (Disease Ontology:DOID:10908)", "pathway": " (rno:171566); (R-RNO-380270); (R-RNO-380320)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "20966424;30484681;33916973;34356103", "class_list": "", "function": "Heterozygous Nme7 Mutation Affects Glucose Tolerance in Male Rats. Publication Status: Online-Only, [RefSeq, PubMed]; Ln a rat model of metabolic syndrome, expression of Nme7 may have relevance for carbohydrate and lipid metabolism as well as ciliogenesis., [RefSeq, PubMed]; Possesses an intrinsic kinase activity. Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing. In vitro, does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner. May maintain primary cilium assembly and ciliary microtubule stability. Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, required for motile cilia beating., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Semi-Lethal Primary Ciliary Dyskinesia in Rats Lacking the Nme7 Gene. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6IDE2;Q6PAG9", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0060972 left/right pattern formation;GO:0010968 regulation of microtubule nucleation;GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QXL7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JIT3-1", "uniprot_id": [ { "id": "TLE3_RAT", "url": "https://www.uniprot.org/uniprot/Q9JIT3", "type": "external" } ], "mass": 82644.0, "length": 764, "protein_name": "Transducin-like enhancer protein 3", "gene_name": "Tle3", "organism": "Rat", "refseq_name": "transducin-like enhancer protein 3 isoform 2", "refseq_ac": [ { "id": "NP_445852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445852", "type": "external" } ], "gene_names_uniprotkb": "Tle3; Esp3", "gene_names_refseq": "Esp3; Tle3", "protein_names_uniprotkb": "Transducin-like enhancer protein 3; rTLE3", "protein_names_refseq": "rTLE3; transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 3 homolog of Drosophila; transducin-like enhancer of split 3, E(spl) homolog; transducin-like enhancer of split 3, homolog of Drosophila E(spl); transducin-like enhancer protein 3 isoform 2; transducin-like enhancer protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:84424); (R-RNO-201722); (R-RNO-3769402); (R-RNO-4641265); (R-RNO-9018519)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10800926;18254933;22673903", "class_list": "", "function": "Transcriptional coregulator that binds to a number of transcription factors. Acts as a regulator of adipogenesis both by acting as a corepressor of Wnt signaling and coactivator for PPARG (By similarity). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (By similarity). Promotes diffentiation of white adipocytes by acting as a coactivator for PPARG and preventing the association between PRDM16 and PPARG, thereby preventing browning of white adipocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0050872 white fat cell differentiation;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0006355 regulation of DNA-templated transcription;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JIT3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L1L2-1", "uniprot_id": [ { "id": "TM214_RAT", "url": "https://www.uniprot.org/uniprot/A1L1L2", "type": "external" } ], "mass": 76566.0, "length": 685, "protein_name": "Transmembrane protein 214", "gene_name": "Tmem214", "organism": "Rat", "refseq_name": "transmembrane protein 214", "refseq_ac": [ { "id": "NP_001014217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014217", "type": "external" } ], "gene_names_uniprotkb": "Tmem214", "gene_names_refseq": "RGD1311324; Tmem214", "protein_names_uniprotkb": "Transmembrane protein 214", "protein_names_refseq": "transmembrane protein 214", "tax_id": 10116, "disease": "", "pathway": " (rno:362711)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5U4F5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L1L2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q68FR8-1", "uniprot_id": [ { "id": "TBA3_RAT", "url": "https://www.uniprot.org/uniprot/Q68FR8", "type": "external" } ], "mass": 49960.0, "length": 450, "protein_name": "Tubulin alpha-3 chain", "gene_name": "Tuba3a; Tuba3b; Tuba8", "organism": "Rat", "refseq_name": "tubulin alpha-3 chain", "refseq_ac": [ { "id": "NP_001019507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019507", "type": "external" } ], "gene_names_uniprotkb": "Tuba3a; Tuba3b; Tuba8; Tuba3", "gene_names_refseq": "RGD1565155; Tuba3b", "protein_names_uniprotkb": "Tubulin alpha-3 chain; 3.6.5.-; Alpha-tubulin 3", "protein_names_refseq": "alpha-tubulin 3; tubulin alpha-3 chain", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234); keratoconus (Disease Ontology:DOID:10126)", "pathway": " (rno:500319); (rno:500363); (R-RNO-190840); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3371497); (R-RNO-380320); (R-RNO-437239); (R-RNO-5610787); (R-RNO-5620920); (R-RNO-5620924); (R-RNO-5626467); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8852276); (R-RNO-8955332); (R-RNO-9646399); (R-RNO-9648025); (R-RNO-9668328); (R-RNO-983189); (R-RNO-9833482)", "pathway_count": 25, "publication_count": 2, "publication_id_list": "38843836;9108330", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.108", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0045121 membrane raft;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q68FR8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B9TQX4-1", "uniprot_id": [ { "id": "UCMA_RAT", "url": "https://www.uniprot.org/uniprot/B9TQX4", "type": "external" } ], "mass": 16574.0, "length": 138, "protein_name": "Unique cartilage matrix-associated protein", "gene_name": "Ucma", "organism": "Rat", "refseq_name": "upper zone of growth plate and cartilage matrix-associated protein precursor", "refseq_ac": [ { "id": "NP_001386279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386279", "type": "external" } ], "gene_names_uniprotkb": "Ucma; Grp", "gene_names_refseq": "GRP; RGD1308977; Ucma", "protein_names_uniprotkb": "Unique cartilage matrix-associated protein; GRP; Gla-rich protein", "protein_names_refseq": "Gla-rich protein; unique cartilage matrix-associated protein; upper zone of growth plate and cartilage matrix-associated protein precursor; upper zone of growth plate and cartilage matrix-associated protein", "tax_id": 10116, "disease": "", "pathway": " (rno:291312)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18836183", "class_list": "", "function": "May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0048471 perinuclear region of cytoplasm;GO:0016235 aggresome", "go_biological_process": "GO:0045668 negative regulation of osteoblast differentiation;GO:0048706 embryonic skeletal system development;GO:0060392 negative regulation of SMAD protein signal transduction;GO:0045667 regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B9TQX4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R037-1", "uniprot_id": [ { "id": "WDR44_RAT", "url": "https://www.uniprot.org/uniprot/Q9R037", "type": "external" } ], "mass": 100948.0, "length": 908, "protein_name": "WD repeat-containing protein 44", "gene_name": "Wdr44", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wdr44; RPH11", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat-containing protein 44; Rab11BP; Rabphilin-11", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10464283;22673903", "class_list": "", "function": "Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:10464283). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:10464283). When bound to Rab11, prevents the formation of the ciliogenic Rab11-Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (By similarity). May participate in neo-synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm;GO:0010008 endosome membrane", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0030334 regulation of cell migration;GO:0060627 regulation of vesicle-mediated transport;GO:0061824 cytosolic ciliogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R037-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYG8-1", "uniprot_id": [ { "id": "UCK2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYG8", "type": "external" } ], "mass": 29404.0, "length": 261, "protein_name": "Uridine-cytidine kinase 2", "gene_name": "Uck2", "organism": "Rat", "refseq_name": "uridine-cytidine kinase 2", "refseq_ac": [ { "id": "NP_001402675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001402675", "type": "external" } ], "gene_names_uniprotkb": "Uck2", "gene_names_refseq": "Uck2; Umpk", "protein_names_uniprotkb": "Uridine-cytidine kinase 2; 2.7.1.48; Cytidine monophosphokinase 2; UCK 2; Uridine monophosphokinase 2", "protein_names_refseq": "UCK 2; cytidine monophosphokinase 2; uridine monophosphate kinase; uridine monophosphokinase 2; uridine-cytidine kinase 2", "tax_id": 10116, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (rno:304944); (R-RNO-73614)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10581173", "class_list": "", "function": "Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2RZ83", "ec_number_list": [ { "id": "2.7.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.48", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004849 uridine kinase activity;GO:0043771 cytidine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage;GO:0016579 protein deubiquitination;GO:0007631 feeding behavior;GO:0048678 response to axon injury", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QYG8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTR7-1", "uniprot_id": [ { "id": "SC11C_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTR7", "type": "external" } ], "mass": 21646.0, "length": 192, "protein_name": "Signal peptidase complex catalytic subunit SEC11C", "gene_name": "Sec11c", "organism": "Rat", "refseq_name": "signal peptidase complex catalytic subunit SEC11C", "refseq_ac": [ { "id": "NP_705892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_705892", "type": "external" } ], "gene_names_uniprotkb": "Sec11c; Sec11l3; Spc21", "gene_names_refseq": "Sec11c; Sec11l3; Spc21", "protein_names_uniprotkb": "Signal peptidase complex catalytic subunit SEC11C; 3.4.21.89; Microsomal signal peptidase 21 kDa subunit; SEC11 homolog C; SEC11-like protein 3; SPC21; SPase 21 kDa subunit", "protein_names_refseq": "SEC11-like protein 3; SPase 21 kDa subunit; Sec11-like 3; microsomal signal peptidase 21 kDa subunit; signal peptidase 21kDa subunit; signal peptidase complex catalytic subunit SEC11C", "tax_id": 10116, "disease": "", "pathway": " (rno:266758); (R-RNO-422085); (R-RNO-9768727)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.89", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008233 peptidase activity;GO:0009003 signal peptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005787 signal peptidase complex;GO:0016020 membrane", "go_biological_process": "GO:0006465 signal peptide processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9WTR7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35119-1", "uniprot_id": [ { "id": "TRPC4_RAT", "url": "https://www.uniprot.org/uniprot/O35119", "type": "external" } ], "mass": 111848.0, "length": 977, "protein_name": "Short transient receptor potential channel 4", "gene_name": "Trpc4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Trpc4", "gene_names_refseq": "", "protein_names_uniprotkb": "Short transient receptor potential channel 4; CCE1; Capacitative calcium entry channel 1; Trp4; TrpC4", "protein_names_refseq": "", "tax_id": 10116, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); neurodegenerative disease (Disease Ontology:DOID:1289); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (R-RNO-3295583)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10980202;11713258;12857742;9037541", "class_list": "", "function": "Forms a non-selective a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein-coupled receptors., [UniProtKB, PubMed]; Forms a receptor-activated non-selective calcium permeant cation channel (By similarity). Acts as a cell-cell contact-dependent endothelial calcium entry channel (By similarity). Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (By similarity). Also permeable to monovalent ions including sodium, lithium and cesium ions (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91ZL9;Q9EQ74;Q9EQ75", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005262 calcium channel activity;GO:0046872 metal ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0051924 regulation of calcium ion transport;GO:0070588 calcium ion transmembrane transport;GO:0014051 gamma-aminobutyric acid secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35119-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z1J8-1", "uniprot_id": [ { "id": "S14L3_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z1J8", "type": "external" } ], "mass": 46027.0, "length": 400, "protein_name": "SEC14-like protein 3", "gene_name": "Sec14l3; Sec14l4", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sec14l3; Sec14l4; Sec14l3; Sec14l4", "gene_names_refseq": "", "protein_names_uniprotkb": "SEC14-like protein 3; 45 kDa secretory protein; rsec45", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:498399)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10350070;22673903", "class_list": "", "function": "Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z1J8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHC6-1", "uniprot_id": [ { "id": "CCN5_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHC6", "type": "external" } ], "mass": 27005.0, "length": 250, "protein_name": "CCN family member 5", "gene_name": "Ccn5", "organism": "Rat", "refseq_name": "CCN family member 5 precursor", "refseq_ac": [ { "id": "NP_113778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113778", "type": "external" } ], "gene_names_uniprotkb": "Ccn5; Cop1; Ctgfl; Wisp2", "gene_names_refseq": "Ccn5; Wisp2", "protein_names_uniprotkb": "CCN family member 5; CCN family protein COP-1; CTGF-L; Connective tissue growth factor-like protein; WISP-2; WNT1-inducible-signaling pathway protein 2", "protein_names_refseq": "CCN family member 5 precursor; CCN family member 5; CCN family protein COP-1; CTGF-L; WISP-2; WNT1 inducible signaling pathway protein 2; connective tissue growth factor-like protein; secreted protein", "tax_id": 10116, "disease": "", "pathway": " (rno:29576)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "14605002;20148653;28167681;32058630;9742130", "class_list": "", "function": "COP-1 immunization might increase NT-3 expression by some unknown mechanism in high IOP rats and the change may be related to COP-1 therapeutic intervention., [RefSeq, PubMed]; Data indicate that CCN5 protein is positively regulated by estrogen in the rat uterus and suggests that this gene may play an important role in maintaining normal uterine physiology, [RefSeq, PubMed]; May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-450a-5p promoted adipogenesis through repressing expression of WISP2 by targeting its 3' untranslated region., [RefSeq, PubMed]; WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARgamma in vitro., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0045597 positive regulation of cell differentiation;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9JHC6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ESQ7-1", "uniprot_id": [ { "id": "PSD1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ESQ7", "type": "external" } ], "mass": 70818.0, "length": 649, "protein_name": "PH and SEC7 domain-containing protein 1", "gene_name": "Psd", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Psd; Efa6; Psd1", "gene_names_refseq": "", "protein_names_uniprotkb": "PH and SEC7 domain-containing protein 1; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; Exchange factor for ARF6 A; Exchange factor for ARF6; Pleckstrin homology and SEC7 domain-containing protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "11834294;22673903;38843836", "class_list": "", "function": "Guanine nucleotide exchange factor for ARF6 (By similarity). Induces cytoskeletal remodeling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0001409 guanine nucleotide transmembrane transporter activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0032154 cleavage furrow;GO:0032587 ruffle membrane", "go_biological_process": "GO:0031175 neuron projection development;GO:0030182 neuron differentiation;GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction;GO:0099562 maintenance of postsynaptic density structure", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9ESQ7-1", "record_type": "protein", "filter_code": "0000000.0000110.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B0BNE2-1", "uniprot_id": [ { "id": "RPAB1_RAT", "url": "https://www.uniprot.org/uniprot/B0BNE2", "type": "external" } ], "mass": 24570.0, "length": 210, "protein_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "gene_name": "Polr2e", "organism": "Rat", "refseq_name": "DNA-directed RNA polymerases I, II, and III subunit RPABC1", "refseq_ac": [ { "id": "NP_001103084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103084", "type": "external" } ], "gene_names_uniprotkb": "Polr2e", "gene_names_refseq": "Polr2e", "protein_names_uniprotkb": "DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-directed RNA polymerase II subunit E; RNA polymerases I, II, and III subunit ABC1; RPB5 homolog", "protein_names_refseq": "DNA-directed RNA polymerase II subunit E; DNA-directed RNA polymerases I, II, and III subunit RPABC1; RNA polymerases I, II, and III subunit ABC1; RPB5 homolog; polymerase (RNA) II (DNA directed) polypeptide E, 25kDa; polymerase (RNA) II subunit E", "tax_id": 10116, "disease": "", "pathway": " (rno:690966); (R-RNO-112382); (R-RNO-113418); (R-RNO-5250924); (R-RNO-5578749); (R-RNO-674695); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-6796648); (R-RNO-6803529); (R-RNO-6807505); (R-RNO-72086); (R-RNO-72163); (R-RNO-72165); (R-RNO-72203); (R-RNO-73762); (R-RNO-73772); (R-RNO-73776); (R-RNO-73779); (R-RNO-73863); (R-RNO-75953); (R-RNO-75955); (R-RNO-76042); (R-RNO-76061); (R-RNO-76066); (R-RNO-76071); (R-RNO-77075); (R-RNO-9018519); (R-RNO-9770562)", "pathway_count": 30, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPABC1 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005665 RNA polymerase II, core complex;GO:0005736 RNA polymerase I complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0042797 tRNA transcription by RNA polymerase III;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0006362 transcription elongation by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B0BNE2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WCG0-1", "uniprot_id": [ { "id": "SERC4_RAT", "url": "https://www.uniprot.org/uniprot/A8WCG0", "type": "external" } ], "mass": 54011.0, "length": 492, "protein_name": "Serine incorporator 4", "gene_name": "Serinc4", "organism": "Rat", "refseq_name": "serine incorporator 4", "refseq_ac": [ { "id": "NP_001402855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001402855", "type": "external" } ], "gene_names_uniprotkb": "Serinc4", "gene_names_refseq": "RGD1566077; Serinc4", "protein_names_uniprotkb": "Serine incorporator 4", "protein_names_refseq": "serine incorporator 4", "tax_id": 10116, "disease": "", "pathway": " (rno:311358); (R-RNO-977347)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16120614", "class_list": "", "function": "Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids., [UniProtKB, UniProtKB]; Serinc proteins incorporate serine into membrane lipid synthesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A8WCG0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5J2-1", "uniprot_id": [ { "id": "B9D1_RAT", "url": "https://www.uniprot.org/uniprot/P0C5J2", "type": "external" } ], "mass": 22655.0, "length": 204, "protein_name": "B9 domain-containing protein 1", "gene_name": "B9d1", "organism": "Rat", "refseq_name": "B9 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001099256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099256", "type": "external" } ], "gene_names_uniprotkb": "B9d1; Eppb9", "gene_names_refseq": "B9d1; Eppb9", "protein_names_uniprotkb": "B9 domain-containing protein 1; Endothelial precursor cells protein B9", "protein_names_refseq": "B9 domain-containing protein 1; B9 protein domain 1; endothelial precursor cells protein B9; endothelial precursor protein B9", "tax_id": 10116, "disease": "Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Joubert syndrome 27 (Disease Ontology:DOID:0110996); nephronophthisis (Disease Ontology:DOID:12712)", "pathway": " (rno:287383); (R-RNO-5620912)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008158 hedgehog receptor activity", "go_cellular_component": "GO:0005813 centrosome;GO:0016020 membrane;GO:0036038 MKS complex;GO:0036064 ciliary basal body;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0032880 regulation of protein localization;GO:0060271 cilium assembly;GO:0060563 neuroepithelial cell differentiation;GO:0001944 vasculature development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C5J2-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923X9-1", "uniprot_id": [ { "id": "TAA8A_RAT", "url": "https://www.uniprot.org/uniprot/Q923X9", "type": "external" } ], "mass": 38065.0, "length": 344, "protein_name": "Trace amine-associated receptor 8a", "gene_name": "Taar8a", "organism": "Rat", "refseq_name": "trace amine-associated receptor 8a", "refseq_ac": [ { "id": "NP_783189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783189", "type": "external" } ], "gene_names_uniprotkb": "Taar8a; Ta11; Tar11; Trar11", "gene_names_refseq": "Ta11; Taar8a; Trar5", "protein_names_uniprotkb": "Trace amine-associated receptor 8a; TaR-11; TaR-8a; Trace amine receptor 11; Trace amine receptor 8a", "protein_names_refseq": "taR-11; taR-8a; trace amine receptor 11; trace amine receptor 5; trace amine receptor 8a; trace amine-associated receptor 8a", "tax_id": 10116, "disease": "", "pathway": " (rno:319104)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11459929;22442117", "class_list": "", "function": "Data show that TAARs were expressed only at trace amounts in most of the tissues, the exceptions being TAAR1 in stomach and testis and TAAR8a in intestine, spleen, and testis., [RefSeq, PubMed]; Olfactory receptor activated by trace amines. Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors. Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q923X9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2Y1-1", "uniprot_id": [ { "id": "TIM_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2Y1", "type": "external" } ], "mass": 138565.0, "length": 1205, "protein_name": "Protein timeless homolog", "gene_name": "Timeless", "organism": "Rat", "refseq_name": "protein timeless homolog", "refseq_ac": [ { "id": "NP_112630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112630", "type": "external" } ], "gene_names_uniprotkb": "Timeless", "gene_names_refseq": "Timeless; Tim; rTIM; rTLP", "protein_names_uniprotkb": "Protein timeless homolog; Timeless-like protein; rTIM; rTLP", "protein_names_refseq": "protein timeless homolog; timeless circadian clock; timeless homolog; timeless-like protein", "tax_id": 10116, "disease": "advanced sleep phase syndrome 4 (Disease Ontology:DOID:0061006); alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (rno:83508); (R-RNO-5693607)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10963667;11112428;15094047;22673903", "class_list": "", "function": "Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (By similarity). Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. During DNA replication, inhibits the CMG complex ATPase activity and activates DNA polymerases catalytic activities, coupling DNA unwinding and DNA synthesis (By similarity). TIMELESS promotes TIPIN nuclear localization (By similarity). Plays a role in maintaining processive DNA replication past genomic guanine-rich DNA sequences that form G-quadruplex (G4) structures, possibly together with DDX11 (By similarity). Involved in cell survival after DNA damage or replication stress by promoting DNA repair (By similarity). In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (By similarity). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity). Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (By similarity). Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (By similarity). May also play an important role in epithelial cell morphogenesis and formation of branching tubules (PubMed:10963667)., [UniProtKB, PubMed, UniProtKB]; The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the Period genes (Per1, Per2, and Per3) and others to downregulate activation of Per1 by Clock/Arntl. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0031298 replication fork protection complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0051301 cell division;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z2Y1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925S8-1", "uniprot_id": [ { "id": "YMEL1_RAT", "url": "https://www.uniprot.org/uniprot/Q925S8", "type": "external" } ], "mass": 79867.0, "length": 715, "protein_name": "ATP-dependent zinc metalloprotease YME1L1", "gene_name": "Potec; Yme1l1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Potec; Yme1l1; Potec; RGD1308454; Yme1l1", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP-dependent zinc metalloprotease YME1L1; 3.4.24.-; 3.6.-.-; ATP-dependent metalloprotease FtsH1; Meg-4; YME1-like protein 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); optic atrophy 11 (Disease Ontology:DOID:0111436); dilated cardiomyopathy (Disease Ontology:DOID:12930); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (rno:364798); (R-RNO-8949664); (R-RNO-9840373)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "38843836", "class_list": "", "function": "ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region. Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (By similarity). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (By similarity). Involved in the mitochondrial adaptation in response to various signals, such as stress or developmental cues, by mediating degradation of mitochondrial proteins to rewire the mitochondrial proteome (By similarity). Catalyzes degradation of mitochondrial proteins, such as translocases, lipid transfer proteins and metabolic enzymes in response to nutrient starvation in order to limit mitochondrial biogenesis: mechanistically, YME1L1 is activated by decreased phosphatidylethanolamine levels caused by LPIN1 activity in response to mTORC1 inhibition (By similarity). Acts as a regulator of adult neural stem cell self-renewal by promoting mitochondrial proteome rewiring, preserving neural stem and progenitor cells self-renewal. Required for normal, constitutive degradation of PRELID1 (By similarity). Catalyzes the degradation of OMA1 in response to membrane depolarization. Mediates degradation of TIMM17A downstream of the integrated stress response (ISR) (By similarity). Catalyzes degradation of MICU1 when MICU1 is not assembled via an interchain disulfide (By similarity). Cleaves STARD7 mitochondrial targeting sequence (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.13.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.4.21.105", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.105", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0004176 ATP-dependent peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0008283 cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0007005 mitochondrion organization;GO:0009267 cellular response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q925S8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQT5-1", "uniprot_id": [ { "id": "TINAL_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQT5", "type": "external" } ], "mass": 52821.0, "length": 467, "protein_name": "Tubulointerstitial nephritis antigen-like", "gene_name": "Tinagl1", "organism": "Rat", "refseq_name": "tubulointerstitial nephritis antigen-like precursor", "refseq_ac": [ { "id": "NP_446034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446034", "type": "external" } ], "gene_names_uniprotkb": "Tinagl1; Gis5; Lcn7; Tinagl", "gene_names_refseq": "Lcn7; Tinagl1; gis5", "protein_names_uniprotkb": "Tubulointerstitial nephritis antigen-like; Glucocorticoid-inducible protein 5", "protein_names_refseq": "glucocorticoid-inducible protein 5; lipocalin 7; tubulointerstitial nephritis antigen-like precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:94174)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043236 laminin binding;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9EQT5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZDK2-1", "uniprot_id": [ { "id": "UB2D1_RAT", "url": "https://www.uniprot.org/uniprot/D3ZDK2", "type": "external" } ], "mass": 16602.0, "length": 147, "protein_name": "Ubiquitin-conjugating enzyme E2 D1", "gene_name": "Ube2d1", "organism": "Rat", "refseq_name": "ubiquitin-conjugating enzyme E2 D1", "refseq_ac": [ { "id": "NP_001102000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102000", "type": "external" } ], "gene_names_uniprotkb": "Ube2d1", "gene_names_refseq": "Ube2d1", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 D1; (E3-independent) E2 ubiquitin-conjugating enzyme D1; 2.3.2.23; 2.3.2.24; E2 ubiquitin-conjugating enzyme D1; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2-17 kDa 1; Ubiquitin-protein ligase D1", "protein_names_refseq": "(E3-independent) E2 ubiquitin-conjugating enzyme D1; E2 ubiquitin-conjugating enzyme D1; ubiquitin carrier protein D1; ubiquitin-conjugating enzyme E2 D1; ubiquitin-conjugating enzyme E2(17)KB 1; ubiquitin-conjugating enzyme E2-17 kDa 1; ubiquitin-protein ligase D1", "tax_id": 10116, "disease": "", "pathway": " (rno:361831); (R-RNO-1234176); (R-RNO-141430); (R-RNO-174048); (R-RNO-174084); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-176407); (R-RNO-176408); (R-RNO-176412); (R-RNO-179409); (R-RNO-201451); (R-RNO-202424); (R-RNO-2173795); (R-RNO-2467813); (R-RNO-2559582); (R-RNO-2871837); (R-RNO-5357905); (R-RNO-5607764); (R-RNO-5689896); (R-RNO-68867); (R-RNO-69017); (R-RNO-8866652); (R-RNO-8866654); (R-RNO-8951664); (R-RNO-9033241); (R-RNO-937041); (R-RNO-9705462); (R-RNO-983168); (R-RNO-9954709); (R-RNO-9954716)", "pathway_count": 32, "publication_count": 1, "publication_id_list": "18359941", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 (By similarity). Mediates ubiquitination of PEX5., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.36", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031398 positive regulation of protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZDK2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08653-1", "uniprot_id": [ { "id": "TEP1_RAT", "url": "https://www.uniprot.org/uniprot/O08653", "type": "external" } ], "mass": 291708.0, "length": 2629, "protein_name": "Telomerase protein component 1", "gene_name": "Tep1", "organism": "Rat", "refseq_name": "telomerase protein component 1", "refseq_ac": [ { "id": "NP_072113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072113", "type": "external" } ], "gene_names_uniprotkb": "Tep1; Tlp1", "gene_names_refseq": "Tep1; Tlp1", "protein_names_uniprotkb": "Telomerase protein component 1; Telomerase protein 1; Telomerase-associated protein 1; p230; p240; p80 telomerase homolog; rTLP1", "protein_names_refseq": "p230; p240; p80 telomerase homolog; rTLP1; telomerase protein 1; telomerase protein component 1", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:64523)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10551828;10864046;9118230", "class_list": "", "function": "Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0002039 p53 binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:1990904 ribonucleoprotein complex;GO:0005697 telomerase holoenzyme complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006278 RNA-templated DNA biosynthetic process;GO:0000722 telomere maintenance via recombination;GO:0006259 DNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O08653-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MI7-1", "uniprot_id": [ { "id": "UBA3_RAT", "url": "https://www.uniprot.org/uniprot/Q99MI7", "type": "external" } ], "mass": 51723.0, "length": 462, "protein_name": "NEDD8-activating enzyme E1 catalytic subunit", "gene_name": "Uba3", "organism": "Rat", "refseq_name": "NEDD8-activating enzyme E1 catalytic subunit", "refseq_ac": [ { "id": "NP_476553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476553", "type": "external" } ], "gene_names_uniprotkb": "Uba3; Ube1c", "gene_names_refseq": "Uba3; Ube1c", "protein_names_uniprotkb": "NEDD8-activating enzyme E1 catalytic subunit; 6.2.1.64; NEDD8-activating enzyme E1C; Ubiquitin-activating enzyme 3; Ubiquitin-activating enzyme E1C; Ubiquitin-like modifier-activating enzyme 3", "protein_names_refseq": "NEDD8-activating enzyme E1 catalytic subunit; NEDD8-activating enzyme E1C; ubiquitin-activating enzyme 3; ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)", "tax_id": 10116, "disease": "", "pathway": " (rno:117553); (R-RNO-5607761); (R-RNO-5676590); (R-RNO-983168)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11818503", "class_list": "", "function": "Activating enzyme of NEDD8 inhibits steroid receptor function, [RefSeq, PubMed]; Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0016922 nuclear receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0045892 negative regulation of DNA-templated transcription;GO:0045116 protein neddylation;GO:0051726 regulation of cell cycle;GO:0007113 endomitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99MI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXQ7-1", "uniprot_id": [ { "id": "WNT5A_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXQ7", "type": "external" } ], "mass": 42283.0, "length": 380, "protein_name": "Protein Wnt-5a", "gene_name": "Wnt5a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Wnt5a; Wnt-5a", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Wnt-5a", "protein_names_refseq": "", "tax_id": 10116, "disease": "Robinow syndrome (Disease Ontology:DOID:0060254); autosomal dominant Robinow syndrome 1 (Disease Ontology:DOID:0060766); colon cancer (Disease Ontology:DOID:219); endometrial carcinoma (Disease Ontology:DOID:2871)", "pathway": " (rno:64566); (R-RNO-201681); (R-RNO-3238698); (R-RNO-4086398); (R-RNO-4086400); (R-RNO-4608870); (R-RNO-5099900); (R-RNO-5140745); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "15309358", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells (By similarity). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5PY99", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0019904 protein domain specific binding;GO:0005125 cytokine activity;GO:0005115 receptor tyrosine kinase-like orphan receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0098794 postsynapse", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0060762 regulation of branching involved in mammary gland duct morphogenesis;GO:1903861 positive regulation of dendrite extension;GO:0043032 positive regulation of macrophage activation;GO:0051057 positive regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QXQ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12001-1", "uniprot_id": [ { "id": "RL18_RAT", "url": "https://www.uniprot.org/uniprot/P12001", "type": "external" } ], "mass": 21659.0, "length": 188, "protein_name": "Large ribosomal subunit protein eL18", "gene_name": "Rpl18", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL18", "refseq_ac": [ { "id": "NP_112364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112364", "type": "external" } ], "gene_names_uniprotkb": "Rpl18", "gene_names_refseq": "Rpl18", "protein_names_uniprotkb": "Large ribosomal subunit protein eL18; 60S ribosomal protein L18", "protein_names_refseq": "60S ribosomal protein L18; large ribosomal subunit protein eL18", "tax_id": 10116, "disease": "Diamond-Blackfan anemia 18 (Disease Ontology:DOID:0111896); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (rno:81766); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 2, "publication_id_list": "22673903;3371159", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0097421 liver regeneration;GO:0002181 cytoplasmic translation;GO:0140236 translation at presynapse;GO:0140242 translation at postsynapse;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P12001-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70141-1", "uniprot_id": [ { "id": "SEM6B_RAT", "url": "https://www.uniprot.org/uniprot/O70141", "type": "external" } ], "mass": 95752.0, "length": 887, "protein_name": "Semaphorin-6B", "gene_name": "Sema6b", "organism": "Rat", "refseq_name": "semaphorin-6B precursor", "refseq_ac": [ { "id": "NP_445923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445923", "type": "external" } ], "gene_names_uniprotkb": "Sema6b", "gene_names_refseq": "Sema6b", "protein_names_uniprotkb": "Semaphorin-6B; Sema Z; Semaphorin-Z", "protein_names_refseq": "sema Z; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B; semaphorin-6B precursor; semaphorin-Z", "tax_id": 10116, "disease": "progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (rno:84609)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "38843836;9427525", "class_list": "", "function": "Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0021766 hippocampus development;GO:0007417 central nervous system development;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O70141-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54800-1", "uniprot_id": [ { "id": "CADH8_RAT", "url": "https://www.uniprot.org/uniprot/O54800", "type": "external" } ], "mass": 88333.0, "length": 799, "protein_name": "Cadherin-8", "gene_name": "Cdh8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Cdh8", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin-8", "protein_names_refseq": "", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); cancer (Disease Ontology:DOID:162)", "pathway": " (R-RNO-418990)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "21454685;22673903;9521872", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O54801", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005912 adherens junction;GO:0043679 axon terminus;GO:0043083 synaptic cleft;GO:0016342 catenin complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0009409 response to cold;GO:0016477 cell migration;GO:0007268 chemical synaptic transmission;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O54800-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0V6-1", "uniprot_id": [ { "id": "PRDX3_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0V6", "type": "external" } ], "mass": 28295.0, "length": 257, "protein_name": "Thioredoxin-dependent peroxide reductase, mitochondrial", "gene_name": "Prdx3", "organism": "Rat", "refseq_name": "thioredoxin-dependent peroxide reductase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_071985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071985", "type": "external" } ], "gene_names_uniprotkb": "Prdx3", "gene_names_refseq": "Prdx3; Prx3", "protein_names_uniprotkb": "Thioredoxin-dependent peroxide reductase, mitochondrial; 1.11.1.24; PRX-3; PRx III; Peroxiredoxin-3; Thioredoxin-dependent peroxiredoxin 3", "protein_names_refseq": "PRX-3; PRx III; thioredoxin-dependent peroxide reductase, mitochondrial precursor; thioredoxin-dependent peroxide reductase, mitochondrial; thioredoxin-dependent peroxiredoxin 3", "tax_id": 10116, "disease": "autosomal recessive spinocerebellar ataxia 32 (Disease Ontology:DOID:0070413); glucose intolerance (Disease Ontology:DOID:10603)", "pathway": " (rno:64371); (R-RNO-3299685)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10025941;26446791;27213235;28828729;29427714;31829064;36566946;36933848", "class_list": "", "function": "DR1 activation inhibits VSMCs proliferation primarily by JNK/c-Jun dependent increasing of Prx3, suggesting DR1 a potential target for the prevention of vascular proliferation disease., [RefSeq, PubMed]; PRDX3 protects against traumatic neuronal injury insult by preserving mitochondrial function and mitochondrial biogenesis., [RefSeq, PubMed]; Peroxiredoxin-3 plays a neuroprotective role in early brain injury after experimental subarachnoid hemorrhage in rats., [RefSeq, PubMed]; Regulation of peroxiredoxin-3 gene expression under basal and hyperglycemic conditions: Key roles for transcription factors Sp1, CREB and NF-kappaB., [RefSeq, PubMed]; The overexpression of LATS2 induces mitochondrial stress by repressing protective mitophagy in a manner dependent on Prx3-Mfn2 pathways, thus reducing the survival of H9C2 cells., [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (By similarity). Required for the maintenance of physical strength (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q6P9W3", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0008379 thioredoxin peroxidase activity;GO:0140824 thioredoxin-dependent peroxiredoxin activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0008284 positive regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0043066 negative regulation of apoptotic process;GO:0051881 regulation of mitochondrial membrane potential", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Z0V6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22934-1", "uniprot_id": [ { "id": "TNR1A_RAT", "url": "https://www.uniprot.org/uniprot/P22934", "type": "external" } ], "mass": 50969.0, "length": 461, "protein_name": "Tumor necrosis factor receptor superfamily member 1A", "gene_name": "Tnfrsf1a", "organism": "Rat", "refseq_name": "tumor necrosis factor receptor superfamily member 1A precursor", "refseq_ac": [ { "id": "NP_037223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037223", "type": "external" } ], "gene_names_uniprotkb": "Tnfrsf1a; Tnfr-1; Tnfr1", "gene_names_refseq": "TNFR-1; Tnfr1; Tnfrsf1a", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor type I; p55; p60", "protein_names_refseq": "TNF-R1; TNF-RI; TNFR-I; p55; p60; tumor necrosis factor receptor 1; tumor necrosis factor receptor superfamily member 1A precursor; tumor necrosis factor receptor superfamily, member 1a; tumor necrosis factor receptor type I", "tax_id": 10116, "disease": "cryptogenic organizing pneumonia (Disease Ontology:DOID:0050157); obstructive sleep apnea (Disease Ontology:DOID:0050848); colorectal adenoma (Disease Ontology:DOID:0050860); lupus nephritis (Disease Ontology:DOID:0080162); polymyositis (Disease Ontology:DOID:0080745); TNF receptorassociated periodic syndrome (Disease Ontology:DOID:0090018); Alzheimer's disease (Disease Ontology:DOID:10652); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); uveitis (Disease Ontology:DOID:13141); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); Behcet's disease (Disease Ontology:DOID:13241); endometrial cancer (Disease Ontology:DOID:1380); root resorption (Disease Ontology:DOID:14550); cystic fibrosis (Disease Ontology:DOID:1485); colon carcinoma (Disease Ontology:DOID:1520); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); glomerulonephritis (Disease Ontology:DOID:2921); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); ischemia (Disease Ontology:DOID:326); fibrosarcoma (Disease Ontology:DOID:3355); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); acne (Disease Ontology:DOID:6543); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); extrinsic allergic alveolitis (Disease Ontology:DOID:841); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); amyloidosis (Disease Ontology:DOID:9120); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25625); (R-RNO-5357786); (R-RNO-5357905); (R-RNO-5357956); (R-RNO-5626978); (R-RNO-5669034); (R-RNO-75893)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "11486281;1702293;32802876;32979866;33066952;34739338;38897255", "class_list": "", "function": "Inflammatory pain in peripheral tissue depends on the activation of the TNF-alpha type 1 receptor in the primary afferent neuron., [RefSeq, PubMed]; Kupffer Cell-Derived TNF-alpha Triggers the Apoptosis of Hepatic Stellate Cells through TNF-R1/Caspase 8 due to ER Stress. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-29a-3p Enhances the Viability of Rat Neuronal Cells that Injured by Oxygen-Glucose Deprivation/Reoxygenation Treatment Through Targeting TNFRSF1A and Regulating NF-kappaB Signaling Pathway., [RefSeq, PubMed]; Receptor for TNFSF2/TNF and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TNFR1 drives the cell death of Paneth cells within the small intestine. This contributes to microibal dysbiosis and pathology in susceptible mice., [RefSeq, PubMed]; Tumor necrosis factor alpha receptor 1A transduces the inhibitory effect on axon regeneration triggered by IgG anti-ganglioside GD1a antibodies., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 45, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5U1X6;Q91V30;Q91Y93", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0043120 tumor necrosis factor binding;GO:0044877 protein-containing complex binding;GO:0005031 tumor necrosis factor receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0043279 response to alkaloid;GO:1903140 regulation of establishment of endothelial barrier;GO:0006952 defense response;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P22934-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0A1-1", "uniprot_id": [ { "id": "VPS25_RAT", "url": "https://www.uniprot.org/uniprot/P0C0A1", "type": "external" } ], "mass": 20762.0, "length": 176, "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "Ramp2; Vps25; Wnk4", "organism": "Rat", "refseq_name": "vacuolar protein-sorting-associated protein 25", "refseq_ac": [ { "id": "NP_001166922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166922", "type": "external" } ], "gene_names_uniprotkb": "Ramp2; Vps25; Wnk4; Eap20; Vps25", "gene_names_refseq": "Vps25", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 25; ELL-associated protein of 20 kDa; ESCRT-II complex subunit VPS25", "protein_names_refseq": "ELL-associated protein of 20 kDa; ESCRT-II complex subunit VPS25; vacuolar protein-sorting-associated protein 25", "tax_id": 10116, "disease": "Gitelman syndrome (Disease Ontology:DOID:0050450); hypertension (Disease Ontology:DOID:10763); cancer (Disease Ontology:DOID:162); transient cerebral ischemia (Disease Ontology:DOID:224); carcinoma (Disease Ontology:DOID:305); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (rno:681059); (R-RNO-917729)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11278625", "class_list": "", "function": "Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form a receptor complex for adrenomedullin/ADM. Together with CALCR, act as a receptor complex for calcitonin/CT/CALC. Together with CALCR, also act as a receptor complex for amylin/IAPP., [UniProtKB, UniProtKB]; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005198 structural molecule activity;GO:0015026 coreceptor activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0000814 ESCRT II complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010008 endosome membrane", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0006351 DNA-templated transcription;GO:0016236 macroautophagy;GO:0007175 negative regulation of epidermal growth factor-activated receptor activity;GO:0071985 multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C0A1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZC96-1", "uniprot_id": [ { "id": "TT39B_RAT", "url": "https://www.uniprot.org/uniprot/D3ZC96", "type": "external" } ], "mass": 70168.0, "length": 617, "protein_name": "Tetratricopeptide repeat protein 39B", "gene_name": "Ttc39b", "organism": "Rat", "refseq_name": "tetratricopeptide repeat protein 39B", "refseq_ac": [ { "id": "NP_001100135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001100135", "type": "external" } ], "gene_names_uniprotkb": "Ttc39b", "gene_names_refseq": "RGD1305797; Ttc39b", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 39B; TPR repeat protein 39B", "protein_names_refseq": "TPR repeat protein 39B; tetratricopeptide repeat protein 39B", "tax_id": 10116, "disease": "", "pathway": " (rno:298186)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29393594", "class_list": "", "function": "Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0090181 regulation of cholesterol metabolic process;GO:0010887 negative regulation of cholesterol storage;GO:0042632 cholesterol homeostasis;GO:0010874 regulation of cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZC96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6N6J5-1", "uniprot_id": [ { "id": "WDR35_RAT", "url": "https://www.uniprot.org/uniprot/A6N6J5", "type": "external" } ], "mass": 132779.0, "length": 1170, "protein_name": "WD repeat-containing protein 35", "gene_name": "Wdr35", "organism": "Rat", "refseq_name": "WD repeat-containing protein 35", "refseq_ac": [ { "id": "NP_001092810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092810", "type": "external" } ], "gene_names_uniprotkb": "Wdr35", "gene_names_refseq": "RGD1564116; Wdr35", "protein_names_uniprotkb": "WD repeat-containing protein 35; Naofen", "protein_names_refseq": "WD repeat-containing protein 35; naofen", "tax_id": 10116, "disease": "cranioectodermal dysplasia 2 (Disease Ontology:DOID:0080804); short-rib thoracic dysplasia 7 with or without polydactyly (Disease Ontology:DOID:0110090); Ellis-Van Creveld syndrome (Disease Ontology:DOID:12714); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (rno:503018); (R-RNO-5610787); (R-RNO-5620924)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "18671723;20193664;20224876;23289926;24803807", "class_list": "", "function": "As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (By similarity). May promote CASP3 activation and TNF-stimulated apoptosis (PubMed:20193664)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Naofen N-terminal protein causes a significant decrease in acetylcholine-induced relaxation of aortic strips from normotensive rats., [RefSeq, PubMed]; Naofen expression may be upregulated by hyperglycemia, with possible correlation to apoptosis of tubular epithelial cells and thereby to diabetic nephropathy. Erratum:[Clin Exp Nephrol. 2010 Jun;14(3):213], [RefSeq, PubMed]; TNF-alpha released from Kupffer cells treated with LPS may induce hepatic naofen expression, which then stimulates hepatocellular apoptosis through activation of caspase-3., [RefSeq, PubMed]; The results of this study indicated that domoic acid activated AMPA/KA receptors and induced ROS production and p38 MAPK phosphorylation, resulting in an increase in the expression of WDR35 in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicated that naofen may function as a novel modulator activating caspase-3, and promoting TNF-alpha-stimulated apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0030991 intraciliary transport particle A", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0032496 response to lipopolysaccharide;GO:0071333 cellular response to glucose stimulus;GO:0071466 cellular response to xenobiotic stimulus;GO:1990830 cellular response to leukemia inhibitory factor", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A6N6J5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920J4-1", "uniprot_id": [ { "id": "TXNL1_RAT", "url": "https://www.uniprot.org/uniprot/Q920J4", "type": "external" } ], "mass": 32249.0, "length": 289, "protein_name": "Thioredoxin-like protein 1", "gene_name": "Txnl1", "organism": "Rat", "refseq_name": "thioredoxin-like protein 1", "refseq_ac": [ { "id": "NP_543163", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543163", "type": "external" } ], "gene_names_uniprotkb": "Txnl1; Trp", "gene_names_refseq": "Txnl1; Txnl", "protein_names_uniprotkb": "Thioredoxin-like protein 1; Thioredoxin-related protein", "protein_names_refseq": "thioredoxin-like (32kD); thioredoxin-like protein 1; thioredoxin-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:140922); (R-RNO-9013418); (R-RNO-9013420); (R-RNO-9013422); (R-RNO-9013424); (R-RNO-9696264); (R-RNO-9696270); (R-RNO-9696273)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "17987124;22673903", "class_list": "", "function": "Active thioredoxin with a redox potential of about -250 mV., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TXNL1 acts as an effector of oxidants or a redox sensor by converting redox changes into changes of GDI capacity to capture Rab5, which in turn modulates fluid phase endocytosis Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q920J4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O55005-1", "uniprot_id": [ { "id": "ROBO1_RAT", "url": "https://www.uniprot.org/uniprot/O55005", "type": "external" } ], "mass": 180748.0, "length": 1651, "protein_name": "Roundabout homolog 1", "gene_name": "Robo1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Robo1; LOC683548", "gene_names_refseq": "", "protein_names_uniprotkb": "Roundabout homolog 1", "protein_names_refseq": "", "tax_id": 10116, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); combined or isolated pituitary hormone deficiency 8 (Disease Ontology:DOID:0061018); autosomal recessive congenital nystagmus 8 (Disease Ontology:DOID:0061178); polymyositis (Disease Ontology:DOID:0080745); dermatomyositis (Disease Ontology:DOID:10223); pre-eclampsia (Disease Ontology:DOID:10591); lung cancer (Disease Ontology:DOID:1324); transient cerebral ischemia (Disease Ontology:DOID:224); cystic kidney disease (Disease Ontology:DOID:2975); plasmacytoma (Disease Ontology:DOID:3721); lung non-small cell carcinoma (Disease Ontology:DOID:3908); diabetic retinopathy (Disease Ontology:DOID:8947); multiple myeloma (Disease Ontology:DOID:9538)", "pathway": " (rno:58946)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10102268;11754167;28859078;9458045", "class_list": "", "function": "Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (By similarity). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (By similarity). May be required for lung development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 14, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030275 LRR domain binding;GO:0008046 axon guidance receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0070100 negative regulation of chemokine-mediated signaling pathway;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O55005-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6ZIQ8-1", "uniprot_id": [ { "id": "TM38A_RAT", "url": "https://www.uniprot.org/uniprot/A6ZIQ8", "type": "external" } ], "mass": 33276.0, "length": 297, "protein_name": "Trimeric intracellular cation channel type A", "gene_name": "Tmem38a", "organism": "Rat", "refseq_name": "trimeric intracellular cation channel type A", "refseq_ac": [ { "id": "NP_001093645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093645", "type": "external" } ], "gene_names_uniprotkb": "Tmem38a", "gene_names_refseq": "RGD1307901; Srp-27; Tmem38a", "protein_names_uniprotkb": "Trimeric intracellular cation channel type A; 27 kDa sarcoplasmic reticulum protein; SPR-27; TRIC-A; TRICA; Transmembrane protein 38A", "protein_names_refseq": "27 kDa sarcoplasmic reticulum protein; SPR-27; TRIC-A; TRICA; trimeric intracellular cation channel type A", "tax_id": 10116, "disease": "", "pathway": " (rno:306327)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18035970", "class_list": "", "function": "Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Opened by a change of voltage within the sarcoplasmic reticulum lumen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SRP-27 is part of a sarcoplasmic reticulum supramolecular complex, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion;GO:0051279 regulation of release of sequestered calcium ion into cytosol;GO:0007029 endoplasmic reticulum organization;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6ZIQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZYB7-1", "uniprot_id": [ { "id": "TAF1B_RAT", "url": "https://www.uniprot.org/uniprot/D3ZYB7", "type": "external" } ], "mass": 68022.0, "length": 586, "protein_name": "TATA box-binding protein-associated factor RNA polymerase I subunit B", "gene_name": "Taf1b", "organism": "Rat", "refseq_name": "TATA box-binding protein-associated factor RNA polymerase I subunit B", "refseq_ac": [ { "id": "NP_001178036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178036", "type": "external" } ], "gene_names_uniprotkb": "Taf1b", "gene_names_refseq": "TAFI63; Taf1b", "protein_names_uniprotkb": "TATA box-binding protein-associated factor RNA polymerase I subunit B; RNA polymerase I-specific TBP-associated factor 63 kDa; TAFI63; TATA box-binding protein-associated factor 1B; TBP-associated factor 1B; Transcription initiation factor SL1/TIF-IB subunit B", "protein_names_refseq": "RNA polymerase I-specific TBP-associated factor 63 kDa; TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B; TATA box-binding protein-associated factor 1B; TATA box-binding protein-associated factor RNA polymerase I subunit B; TBP-associated factor 1B; transcription initiation factor SL1/TIF-IB subunit B", "tax_id": 10116, "disease": "mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); Lynch syndrome (Disease Ontology:DOID:3883)", "pathway": " (rno:690450); (R-RNO-5250924); (R-RNO-73762); (R-RNO-73772); (R-RNO-73863)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005668 RNA polymerase transcription factor SL1 complex;GO:0005730 nucleolus;GO:0070860 RNA polymerase I core factor complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I;GO:0001188 RNA polymerase I preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZYB7-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZTX0-1", "uniprot_id": [ { "id": "TMED7_RAT", "url": "https://www.uniprot.org/uniprot/D3ZTX0", "type": "external" } ], "mass": 25479.0, "length": 226, "protein_name": "Transmembrane emp24 domain-containing protein 7", "gene_name": "Ticam2; Tmed7", "organism": "Rat", "refseq_name": "transmembrane emp24 domain-containing protein 7 precursor", "refseq_ac": [ { "id": "NP_001099228", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099228", "type": "external" } ], "gene_names_uniprotkb": "Ticam2; Tmed7; Ticam2; Tmed7", "gene_names_refseq": "Tmed7; p27", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 7; p24 family protein gamma-3; p24gamma3; p27", "protein_names_refseq": "UV36Sp6 ultraviolet B radiation-activated UV36; p24 family protein gamma-3; p24gamma3; transmembrane emp24 domain-containing protein 7 precursor; transmembrane emp24 domain-containing protein 7; transmembrane emp24 protein transport domain containing 7", "tax_id": 10116, "disease": "Coronavirus infectious disease (Disease Ontology:DOID:0080599)", "pathway": " (rno:252889); (rno:364867); (R-RNO-140534); (R-RNO-166016); (R-RNO-166166); (R-RNO-2562578); (R-RNO-6798695); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-936964); (R-RNO-937041); (R-RNO-937072); (R-RNO-975163); (R-RNO-9824878)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "9472029", "class_list": "", "function": "Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria., [UniProtKB, UniProtKB, UniProtKB]; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005543 phospholipid binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization;GO:0015031 protein transport;GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZTX0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZFW5-1", "uniprot_id": [ { "id": "TM107_RAT", "url": "https://www.uniprot.org/uniprot/D3ZFW5", "type": "external" } ], "mass": 15591.0, "length": 140, "protein_name": "Transmembrane protein 107", "gene_name": "Tmem107", "organism": "Rat", "refseq_name": "transmembrane protein 107", "refseq_ac": [ { "id": "NP_001103118", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103118", "type": "external" } ], "gene_names_uniprotkb": "Tmem107", "gene_names_refseq": "Tmem107", "protein_names_uniprotkb": "Transmembrane protein 107", "protein_names_refseq": "transmembrane protein 107", "tax_id": 10116, "disease": "Meckel syndrome 13 (Disease Ontology:DOID:0080253); orofaciodigital syndrome XVI (Disease Ontology:DOID:0080254)", "pathway": " (rno:691750)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0016020 membrane;GO:0036038 MKS complex;GO:0035869 ciliary transition zone;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0097094 craniofacial suture morphogenesis;GO:0003127 detection of nodal flow;GO:0060271 cilium assembly;GO:0007368 determination of left/right symmetry;GO:0060021 roof of mouth development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D3ZFW5-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZHP7-1", "uniprot_id": [ { "id": "ULK3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZHP7", "type": "external" } ], "mass": 53419.0, "length": 472, "protein_name": "Serine/threonine-protein kinase ULK3", "gene_name": "Ulk3", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase ULK3", "refseq_ac": [ { "id": "NP_001258064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258064", "type": "external" } ], "gene_names_uniprotkb": "Ulk3", "gene_names_refseq": "Ulk3", "protein_names_uniprotkb": "Serine/threonine-protein kinase ULK3; 2.7.11.1; Unc-51-like kinase 3", "protein_names_refseq": "serine/threonine-protein kinase ULK3", "tax_id": 10116, "disease": "", "pathway": " (rno:691171); (R-RNO-5632684)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20643644;22673903", "class_list": "", "function": "Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway., [RefSeq, PubMed]; Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy., [UniProtKB, UniProtKB, UniProtKB]; Serine/threonine protein kinase that acts as a regulator of smoothened signaling and autophagy. Acts as a positive regulator of smoothened signaling in the presence of hedgehog (DHH, IHH or SHH) ligand: autophosphorylates and mediates phosphorylation of full-length GLI2, promoting subsequent phosphorylation by CDK1 and GLI2 dissociation from SUFU and translocation to the nucleus. Also phosphorylates as GLI1 and GLI3, although less efficiently. In the absence of hedgehog ligand, interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0000045 autophagosome assembly;GO:0010506 regulation of autophagy;GO:0042594 response to starvation;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZHP7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B5DEQ3-1", "uniprot_id": [ { "id": "XPP3_RAT", "url": "https://www.uniprot.org/uniprot/B5DEQ3", "type": "external" } ], "mass": 56455.0, "length": 506, "protein_name": "Xaa-Pro aminopeptidase 3", "gene_name": "Xpnpep3", "organism": "Rat", "refseq_name": "xaa-Pro aminopeptidase 3", "refseq_ac": [ { "id": "NP_001124054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124054", "type": "external" } ], "gene_names_uniprotkb": "Xpnpep3", "gene_names_refseq": "APP3; Xpnpep3", "protein_names_uniprotkb": "Xaa-Pro aminopeptidase 3; 3.4.11.9; APP3; Aminopeptidase P3; X-Pro aminopeptidase 3", "protein_names_refseq": "X-Pro aminopeptidase 3; X-prolyl aminopeptidase 3, mitochondrial; aminopeptidase P3; probable Xaa-Pro aminopeptidase 3; xaa-Pro aminopeptidase 3", "tax_id": 10116, "disease": "nephronophthisis-like nephropathy 1 (Disease Ontology:DOID:0111117)", "pathway": " (rno:685823)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20179356", "class_list": "", "function": "Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0003094 glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B5DEQ3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1S4-1", "uniprot_id": [ { "id": "XBP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1S4", "type": "external" } ], "mass": 29665.0, "length": 267, "protein_name": "X-box-binding protein 1", "gene_name": "Xbp1", "organism": "Rat", "refseq_name": "X-box-binding protein 1 isoform XBP1(U)", "refseq_ac": [ { "id": "NP_001004210", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004210", "type": "external" } ], "gene_names_uniprotkb": "Xbp1; Htf", "gene_names_refseq": "HTF; Xbp1", "protein_names_uniprotkb": "X-box-binding protein 1; HTF; Hepatocarcinogenesis-related transcription factor", "protein_names_refseq": "X-box-binding protein 1 isoform XBP1(U); hepatocarcinogenesis-related transcription factor", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); borna disease (Disease Ontology:DOID:5154)", "pathway": " (rno:289754)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10675042;34676402;34964131;35008595;35497095;36705422", "class_list": "", "function": "Acts as a weak transcriptional factor. Together with HDAC3, contributes to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to EC survival under disturbed flow/oxidative stress. Binds to the ER stress response element (ERSE) upon ER stress. Binds to the consensus 5'-GATGACGTG[TG]N(3)[AT]T-3' sequence related to cAMP responsive element (CRE)-like sequences. Associates preferentially to the HDAC3 gene promoter region in a static flow-dependent manner. Binds to the CDH5/VE-cadherin gene promoter region., [UniProtKB, UniProtKB, UniProtKB]; Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis. Publication Status: Online-Only, [RefSeq, PubMed]; Effect of Denervation on XBP1 in Skeletal Muscle and the Neuromuscular Junction. Publication Status: Online-Only, [RefSeq, PubMed]; Exosomal miR-205-5p derived from periodontal ligament stem cells attenuates the inflammation of chronic periodontitis via targeting XBP1., [RefSeq, PubMed]; Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes. Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention., [UniProtKB, UniProtKB, UniProtKB]; Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary hypertension through the p-JNK MAPK pathway., [RefSeq, PubMed]; Xbp1s-Ddit3 promotes MCT-induced pulmonary hypertension., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:2000347 positive regulation of hepatocyte proliferation;GO:0031670 cellular response to nutrient;GO:1901985 positive regulation of protein acetylation;GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9R1S4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68370-1", "uniprot_id": [ { "id": "TBA1A_RAT", "url": "https://www.uniprot.org/uniprot/P68370", "type": "external" } ], "mass": 50136.0, "length": 451, "protein_name": "Tubulin alpha-1A chain", "gene_name": "Tuba1a; Tuba1b", "organism": "Rat", "refseq_name": "tubulin alpha-1A chain", "refseq_ac": [ { "id": "NP_071634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071634", "type": "external" } ], "gene_names_uniprotkb": "Tuba1a; Tuba1b; Tuba1a; Tuba1b; Tuba1", "gene_names_refseq": "Tuba1a; Tuba1", "protein_names_uniprotkb": "Tubulin alpha-1A chain; 3.6.5.-; Alpha-tubulin 1; Tubulin alpha-1 chain", "protein_names_refseq": "alpha-tubulin 1; tubulin alpha-1 chain; tubulin alpha-1A chain; tubulin, alpha 1", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234); microcephaly (Disease Ontology:DOID:10907); Down syndrome (Disease Ontology:DOID:14250); congenital nervous system abnormality (Disease Ontology:DOID:2490)", "pathway": " (rno:64158); (R-RNO-190840); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-3371497); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-437239); (R-RNO-5610787); (R-RNO-5620912); (R-RNO-5620920); (R-RNO-5620924); (R-RNO-5626467); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8852276); (R-RNO-8854518); (R-RNO-8955332); (R-RNO-9646399); (R-RNO-9648025); (R-RNO-9668328); (R-RNO-983189); (R-RNO-9833482)", "pathway_count": 30, "publication_count": 11, "publication_id_list": "12397027;21933451;27314403;30582931;34502162;35486479;38843836;6269058;6927856;7328649;9108330", "class_list": "", "function": "Alpha-Tubulin acetylation on lysine 40 controls cardiac glucose uptake., [RefSeq, PubMed]; HDAC6-mediated alpha-tubulin acetylation is an important mechanism of acidic pH-dependent autophagy in cardiomyocytes., [RefSeq, PubMed]; These results agree with the hypothesis that the acetylation of alpha-tubulin by ATAT1 regulates the intracellular transport of secretory granules in corticotrophs., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02551;P05210;P05212;Q6P6G6", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.108", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0016787 hydrolase activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0046785 microtubule polymerization;GO:0021696 cerebellar cortex morphogenesis;GO:0001964 startle response;GO:0000278 mitotic cell cycle;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P68370-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MC0-1", "uniprot_id": [ { "id": "PP14A_RAT", "url": "https://www.uniprot.org/uniprot/Q99MC0", "type": "external" } ], "mass": 16697.0, "length": 147, "protein_name": "Protein phosphatase 1 regulatory subunit 14A", "gene_name": "Ppp1r14a", "organism": "Rat", "refseq_name": "protein phosphatase 1 regulatory subunit 14A", "refseq_ac": [ { "id": "NP_569087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569087", "type": "external" } ], "gene_names_uniprotkb": "Ppp1r14a; Cpi17; Cpi", "gene_names_refseq": "CPI-17; Cpi17; Ppp1r14a", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; CPI-17; Protein kinase C-potentiated inhibitor protein of 17 kDa", "protein_names_refseq": "17 kDa PKC-potentiated inhibitory protein of PP1; protein kinase C-potentiated inhibitor protein of 17 kDa; protein phosphatase 1 regulatory subunit 14A", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (rno:114004); (R-RNO-5625740)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "11931393;12144526;12359219;12974676;16040632;16267107;16763289;16953424;19296091;20046026;21787615;21827498;22004427;22673903;24909118;25502873;27706026;28717991;38474189", "class_list": "", "function": "Agonists induce PHI-1 phosphorylation in VSMCs and divergent kinase signaling couples agonist stimulation to PHI-1 and CPI-17 phosphorylation., [RefSeq, PubMed]; An impairment of the rapid CPI-17 signaling pathway mediating alpha1A-adrenoceptor activation is a cause of hypo-responsiveness of splanchnic resistance arteries, as an end organ of orthostatic blood pressure reflex, in the orthostatic hypotension model rats, [RefSeq, PubMed]; Distribution of mouse and rat PPP1R14A was more specific and different from that of humans, [RefSeq, PubMed]; Emodin attenuates tonic tension through the blockade of PKCdelta and CPI-17-mediated MLC-phosphatase inhibition., [RefSeq, PubMed]; ILK may activate smooth-muscle contraction both directly, via phosphorylation of myosin, and indirectly, via phosphorylation and activation of CPI-17 and PHI-1, leading to inhibition of myosin light-chain phosphatase, [RefSeq, PubMed]; Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylated by p21-activated kinase, [RefSeq, PubMed]; Rac1 coordinates with RhoA to increase myosin light chain (MLC) phosphorylation by inactivation of CPI-17/MYPT1 phosphatase, which decreases MLC phosphatase activity thus promoting MLC phosphorylation and cell contraction, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0071466 cellular response to xenobiotic stimulus", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q99MC0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B6ID01-1", "uniprot_id": [ { "id": "TM216_RAT", "url": "https://www.uniprot.org/uniprot/B6ID01", "type": "external" } ], "mass": 16174.0, "length": 141, "protein_name": "Transmembrane protein 216", "gene_name": "Tmem216", "organism": "Rat", "refseq_name": "transmembrane protein 216", "refseq_ac": [ { "id": "NP_001257968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257968", "type": "external" } ], "gene_names_uniprotkb": "Tmem216", "gene_names_refseq": "RGD1304607; Tmem216", "protein_names_uniprotkb": "Transmembrane protein 216", "protein_names_refseq": "transmembrane protein 216", "tax_id": 10116, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); retinitis pigmentosa 98 (Disease Ontology:DOID:0061109); Meckel syndrome 2 (Disease Ontology:DOID:0070116); Joubert syndrome 2 (Disease Ontology:DOID:0110988)", "pathway": " (rno:361727); (R-RNO-5620912)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential for primary ciliogenesis and embryonic development, facilitating the activation of Hedgehog (Hh) signaling pathway. Disrupts the interaction of GLI2 and GLI3 with the negative regulator SUFU. Inhibiting SUFU's interaction with GLI2 promotes the entry of GLI2 into the nucleus, allowing it to activate Hh target gene expression. Disrupting SUFU's interaction with GLI3 prevents its conversion into the repressor form, leading to increased nuclear GLI3 and enhanced Hh signaling. Required for the proper development and structural integrity of photoreceptor outer segment disks, ensuring normal outer segment morphogenesis and survival of photoreceptors., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4A451", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0016020 membrane;GO:0036038 MKS complex;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0045494 photoreceptor cell maintenance;GO:0060271 cilium assembly;GO:1905515 non-motile cilium assembly;GO:0045724 positive regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B6ID01-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19637-1", "uniprot_id": [ { "id": "TPA_RAT", "url": "https://www.uniprot.org/uniprot/P19637", "type": "external" } ], "mass": 62903.0, "length": 559, "protein_name": "Tissue-type plasminogen activator", "gene_name": "Plat", "organism": "Rat", "refseq_name": "tissue-type plasminogen activator precursor", "refseq_ac": [ { "id": "NP_037283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037283", "type": "external" } ], "gene_names_uniprotkb": "Plat", "gene_names_refseq": "PATISS; Plat; tPA", "protein_names_uniprotkb": "Tissue-type plasminogen activator; 3.4.21.68; t-PA; t-plasminogen activator; tPA", "protein_names_refseq": "t-PA; t-plasminogen activator; tissue plasminogen activator; tissue-type plasminogen activator precursor; tissue-type plasminogen activator-like; tissue-type plasminogen activator", "tax_id": 10116, "disease": "stroke (Disease Ontology:DOID:0051061); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); von Willebrand's disease 1 (Disease Ontology:DOID:0060573); osteonecrosis (Disease Ontology:DOID:10159); IgA vasculitis (Disease Ontology:DOID:11123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); sciatic neuropathy (Disease Ontology:DOID:11446); diabetic angiopathy (Disease Ontology:DOID:11713); gestational diabetes (Disease Ontology:DOID:11714); factor VIII deficiency (Disease Ontology:DOID:12134); blood coagulation disease (Disease Ontology:DOID:1247); hemolytic-uremic syndrome (Disease Ontology:DOID:12554); Parkinson's disease (Disease Ontology:DOID:14330); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); severe acute respiratory syndrome (Disease Ontology:DOID:2945); antiphospholipid syndrome (Disease Ontology:DOID:2988); acute kidney failure (Disease Ontology:DOID:3021); Noonan syndrome (Disease Ontology:DOID:3490); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); brain edema (Disease Ontology:DOID:4724); myocardial infarction (Disease Ontology:DOID:5844); leukopenia (Disease Ontology:DOID:615); peritonitis (Disease Ontology:DOID:8283); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:25692); (R-RNO-186797); (R-RNO-75205)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "1515147;2105315;29304073;3148445;31848365;34968722;36283468;38360257", "class_list": "", "function": "Astrocyte tissue plasminogen activator expression during brain development and its role in pyramidal neuron neurite outgrowth., [RefSeq, PubMed]; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (PubMed:1515147)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; T-PA expressed in ECs may help to form IT of the DA via activation of MMP-2 and disruption of IEL Publication Status: Online-Only, [RefSeq, PubMed]; The interplay between MMP-12 and t-PA in the brain after ischemic stroke., [RefSeq, PubMed]; The paradox of tPA in ischemic stroke: tPA knockdown following recanalization improves functional and histological outcomes., [RefSeq, PubMed]; Tissue-type plasminogen activator-primed human iPSC-derived neural progenitor cells promote motor recovery after severe spinal cord injury. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.68", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098992 neuronal dense core vesicle;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface", "go_biological_process": "GO:0006508 proteolysis;GO:0001666 response to hypoxia;GO:0014909 smooth muscle cell migration;GO:0035249 synaptic transmission, glutamatergic;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P19637-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21533-1", "uniprot_id": [ { "id": "RL6_RAT", "url": "https://www.uniprot.org/uniprot/P21533", "type": "external" } ], "mass": 33562.0, "length": 298, "protein_name": "Large ribosomal subunit protein eL6", "gene_name": "Rpl6", "organism": "Rat", "refseq_name": "large ribosomal subunit protein eL6", "refseq_ac": [ { "id": "NP_446423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446423", "type": "external" } ], "gene_names_uniprotkb": "Rpl6", "gene_names_refseq": "Rpl6", "protein_names_uniprotkb": "Large ribosomal subunit protein eL6; 60S ribosomal protein L6; Neoplasm-related protein C140", "protein_names_refseq": "60S ribosomal protein L6; large ribosomal subunit protein eL6; neoplasm-related protein C140", "tax_id": 10116, "disease": "", "pathway": " (rno:117042); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 11, "publication_count": 4, "publication_id_list": "20410138;398910;8185817;8828793", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4QRA9;Q64624;Q68G26", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000049 tRNA binding;GO:1990932 5.8S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0036464 cytoplasmic ribonucleoprotein granule", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P21533-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZU96-1", "uniprot_id": [ { "id": "UBP42_RAT", "url": "https://www.uniprot.org/uniprot/D3ZU96", "type": "external" } ], "mass": 146357.0, "length": 1325, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 42", "gene_name": "Usp42", "organism": "Rat", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 42", "refseq_ac": [ { "id": "NP_001099379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099379", "type": "external" } ], "gene_names_uniprotkb": "Usp42", "gene_names_refseq": "Usp42", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 42; 3.4.19.12; Deubiquitinating enzyme 42; Ubiquitin thioesterase 42; Ubiquitin-specific-processing protease 42", "protein_names_refseq": "deubiquitinating enzyme 42; ubiquitin carboxyl-terminal hydrolase 42; ubiquitin specific protease 42; ubiquitin thioesterase 42; ubiquitin thiolesterase 42; ubiquitin-specific-processing protease 42", "tax_id": 10116, "disease": "congenital heart disease (Disease Ontology:DOID:1682); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (rno:288482); (R-RNO-5689880)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "Deubiquitinating enzyme which may play an important role during spermatogenesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0016579 protein deubiquitination;GO:0030154 cell differentiation;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZU96-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C5J5-1", "uniprot_id": [ { "id": "WFKN1_RAT", "url": "https://www.uniprot.org/uniprot/P0C5J5", "type": "external" } ], "mass": 59915.0, "length": 552, "protein_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1", "gene_name": "Wfikkn1", "organism": "Rat", "refseq_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001123248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123248", "type": "external" } ], "gene_names_uniprotkb": "Wfikkn1; Oc29", "gene_names_refseq": "Oc29; RGD1565835; Wfikkn1", "protein_names_uniprotkb": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1", "protein_names_refseq": "WAP, FS, Ig, KU, and NTR-containing protein 1; WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 precursor; WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:363555)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15497143", "class_list": "", "function": "OC29 may have a role in the early development of the inner ear sensory organ, particularly in the formation of the cristae of the semicircular canals [OC29], [RefSeq, PubMed]; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0048019 receptor antagonist activity;GO:0050431 transforming growth factor beta binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0001501 skeletal system development;GO:0060021 roof of mouth development;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0055001 muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C5J5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0G8-1", "uniprot_id": [ { "id": "WIPF3_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0G8", "type": "external" } ], "mass": 49381.0, "length": 485, "protein_name": "WAS/WASL-interacting protein family member 3", "gene_name": "Wipf3", "organism": "Rat", "refseq_name": "WAS/WASL-interacting protein family member 3 isoform 2", "refseq_ac": [ { "id": "NP_671744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671744", "type": "external" } ], "gene_names_uniprotkb": "Wipf3; Cr16", "gene_names_refseq": "Cr16; Wipf3", "protein_names_uniprotkb": "WAS/WASL-interacting protein family member 3; Corticosteroids and regional expression protein 16", "protein_names_refseq": "SH3 domain binding protein CR16; WAS/WASL-interacting protein family member 3 isoform 2; corticosteroids and regional expression protein 16", "tax_id": 10116, "disease": "", "pathway": " (rno:259242); (R-RNO-2029482); (R-RNO-5663213)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11553796;16182290;17418095;22673903;2357595;8839352;8906616", "class_list": "", "function": "May have a role in spermatogenesis (By similarity). May be a regulator of cytoskeletal organization., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q62775", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0045202 synapse;GO:0055037 recycling endosome;GO:0071203 WASH complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0042147 retrograde transport, endosome to Golgi;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9Z0G8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35397-1", "uniprot_id": [ { "id": "CASP6_RAT", "url": "https://www.uniprot.org/uniprot/O35397", "type": "external" } ], "mass": 31556.0, "length": 277, "protein_name": "Caspase-6", "gene_name": "Casp6", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Casp6; Mch2", "gene_names_refseq": "", "protein_names_uniprotkb": "Caspase-6; 3.4.22.59; Apoptotic protease Mch-2; CASP-6", "protein_names_refseq": "", "tax_id": 10116, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); endometritis (Disease Ontology:DOID:1002); prostate carcinoma (Disease Ontology:DOID:10286); Alzheimer's disease (Disease Ontology:DOID:10652); prostatic hypertrophy (Disease Ontology:DOID:11132); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); middle cerebral artery infarction (Disease Ontology:DOID:3525); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (R-RNO-111465); (R-RNO-264870); (R-RNO-352238)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9530276", "class_list": "", "function": "Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (By similarity). Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation. Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution (By similarity). Acts as a regulator of liver damage by promoting hepatocyte apoptosis: in absence of phosphorylation by AMP-activated protein kinase (AMPK), catalyzes cleavage of BID, leading to cytochrome c release, thereby participating in nonalcoholic steatohepatitis. Cleaves PARK7/DJ-1 in cells undergoing apoptosis (By similarity). Involved in intrinsic apoptosis by mediating cleavage of RIPK1. Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (By similarity). Cleaves phospholipid scramblase proteins XKR4 and XKR9. In addition to apoptosis, involved in different forms of programmed cell death. Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity. PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis. Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death. Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis. Regulates B-cell programs both during early development and after antigen stimulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.59", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030424 axon", "go_biological_process": "GO:0002525 acute inflammatory response to non-antigenic stimulus;GO:0046670 positive regulation of retinal cell programmed cell death;GO:0006508 proteolysis;GO:0010332 response to gamma radiation;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O35397-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8R2H2-1", "uniprot_id": [ { "id": "ITB3_RAT", "url": "https://www.uniprot.org/uniprot/Q8R2H2", "type": "external" } ], "mass": 86930.0, "length": 787, "protein_name": "Integrin beta-3", "gene_name": "Itgb3", "organism": "Rat", "refseq_name": "integrin beta-3 precursor", "refseq_ac": [ { "id": "NP_714942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714942", "type": "external" } ], "gene_names_uniprotkb": "Itgb3", "gene_names_refseq": "GPIIIa; Itgb3", "protein_names_uniprotkb": "Integrin beta-3; GPIIIa; Platelet membrane glycoprotein IIIa", "protein_names_refseq": "integrin beta 3 (Cd61); integrin beta-3 precursor; integrin, beta 3; platelet membrane glycoprotein IIIa", "tax_id": 10116, "disease": "non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); platelet-type bleeding disorder 16 (Disease Ontology:DOID:0060691); colorectal carcinoma (Disease Ontology:DOID:0080199); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); Graves' disease (Disease Ontology:DOID:12361); thrombocytopenia (Disease Ontology:DOID:1588); cancer (Disease Ontology:DOID:162); blood platelet disease (Disease Ontology:DOID:2218); Glanzmann's thrombasthenia (Disease Ontology:DOID:2219); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); lung non-small cell carcinoma (Disease Ontology:DOID:3908); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); bacterial pneumonia (Disease Ontology:DOID:874); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (rno:29302); (R-RNO-114608); (R-RNO-1566948); (R-RNO-210990); (R-RNO-2129379); (R-RNO-216083); (R-RNO-2173789); (R-RNO-3000170); (R-RNO-3000178); (R-RNO-354192); (R-RNO-354194); (R-RNO-372708); (R-RNO-4420097); (R-RNO-445144); (R-RNO-5674135); (R-RNO-9769733); (R-RNO-9860927)", "pathway_count": 17, "publication_count": 7, "publication_id_list": "10640428;18317590;18549786;30507047;31964805;32351169;37062956", "class_list": "", "function": "Ca(2+) waves coordinate purinergic receptor-evoked integrin activation and polarization. Publication Status: Online-Only, [RefSeq, PubMed]; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (By similarity). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (By similarity). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin (By similarity). Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (PubMed:18549786). ITGAV:ITGB3 acts as a receptor for CD40LG (By similarity). ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (PubMed:10640428). Integrin ITGA2B:ITGB3 is also the receptor of the erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed]; Integrin alphanubeta3 modulates lipopolysaccharide-induced hyperpermeability in cardiac microvascular endothelial cells., [RefSeq, PubMed]; MiR-223-3p alleviated the progression of pulmonary arterial hypertension by suppressing the expression of ITGB3, a finding which provides novel targets for clinical treatment., [RefSeq, PubMed]; Reduced expression of Il10, Stat3, Hoxa10, and Itgb3 in the embryo implantation site of rat model with prenatal androgen-induced polycystic ovary syndrome., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "M0RCF3", "ec_number_list": [], "go_molecular_function": "GO:0038132 neuregulin binding;GO:0002020 protease binding;GO:0005178 integrin binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0072126 positive regulation of glomerular mesangial cell proliferation;GO:0007044 cell-substrate junction assembly;GO:0010888 negative regulation of lipid storage;GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8R2H2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17074-1", "uniprot_id": [ { "id": "RS19_RAT", "url": "https://www.uniprot.org/uniprot/P17074", "type": "external" } ], "mass": 16085.0, "length": 145, "protein_name": "Small ribosomal subunit protein eS19", "gene_name": "LOC120095010; Rps19l3; Rps19", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS19", "refseq_ac": [ { "id": "NP_001032423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032423", "type": "external" } ], "gene_names_uniprotkb": "LOC120095010; Rps19l3; Rps19; LOC100360843; LOC120095010; Rps19l3; Rps19l4", "gene_names_refseq": "Rps19l2; Rps19", "protein_names_uniprotkb": "Small ribosomal subunit protein eS19; 40S ribosomal protein S19", "protein_names_refseq": "40S ribosomal protein S19; ribosomal protein S19-like2; small ribosomal subunit protein eS19", "tax_id": 10116, "disease": "Diamond-Blackfan anemia 1 (Disease Ontology:DOID:0111895); aplastic anemia (Disease Ontology:DOID:12449); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (rno:100360843); (rno:29287); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "2116918", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0017134 fibroblast growth factor binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007000 nucleolus organization;GO:0007219 Notch signaling pathway;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0030218 erythrocyte differentiation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P17074-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MA59-1", "uniprot_id": [ { "id": "F1MA59_RAT", "url": "https://www.uniprot.org/uniprot/F1MA59", "type": "external" } ], "mass": 160613.0, "length": 1669, "protein_name": "Collagen type IV alpha 1 chain", "gene_name": "Col4a1", "organism": "Rat", "refseq_name": "collagen alpha-1(IV) chain precursor", "refseq_ac": [ { "id": "NP_001128481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128481", "type": "external" } ], "gene_names_uniprotkb": "Col4a1", "gene_names_refseq": "Col4a1", "protein_names_uniprotkb": "Collagen type IV alpha 1 chain", "protein_names_refseq": "alpha 1 type IV collagen; collagen alpha-1(IV) chain precursor; collagen alpha-1(IV) chain; collagen, type IV, alpha 1; procollagen, type IV, alpha 1", "tax_id": 10116, "disease": "Walker-Warburg syndrome (Disease Ontology:DOID:0050560); stroke (Disease Ontology:DOID:0051061); porencephaly (Disease Ontology:DOID:0060263); brain small vessel disease 1 (Disease Ontology:DOID:0090125); retinal arterial tortuosity (Disease Ontology:DOID:0111547); uterine fibroid (Disease Ontology:DOID:13223); myopathy (Disease Ontology:DOID:423); kidney disease (Disease Ontology:DOID:557); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); collagen disease (Disease Ontology:DOID:854); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:290905); (R-RNO-1442490); (R-RNO-1566977); (R-RNO-1650814); (R-RNO-186797); (R-RNO-2022090); (R-RNO-216083); (R-RNO-2243919); (R-RNO-3000157); (R-RNO-3000171); (R-RNO-419037)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "27530924;31480394;36281728", "class_list": "", "function": "Glomerular collagen deposition and increased lipocalin-2 expression were the early signs of kidney injury. Publication Status: Online-Only, [RefSeq, PubMed]; Hypoxia-induced upregulation of matrix metalloproteinase 9 increases basement membrane degradation by downregulating collagen type IV alpha 1 chain., [RefSeq, PubMed]; PTH pretreatment prevented TGF-beta1 and high glucose-induced Smad2/3 phosphorylation and consequent upregulation of fibronectin and type IV collagen within 4 h., [RefSeq, PubMed]; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 0, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0005604 basement membrane;GO:0005581 collagen trimer;GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005587 collagen type IV trimer", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0030198 extracellular matrix organization;GO:0030855 epithelial cell differentiation;GO:0007420 brain development;GO:0048514 blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1MA59-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ADV8-1", "uniprot_id": [ { "id": "D4ADV8_RAT", "url": "https://www.uniprot.org/uniprot/D4ADV8", "type": "external" } ], "mass": 78365.0, "length": 718, "protein_name": "Dishevelled segment polarity protein 3", "gene_name": "Dvl3", "organism": "Rat", "refseq_name": "segment polarity protein dishevelled homolog DVL-3 isoform X1", "refseq_ac": [ { "id": "XP_063126544", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_063126544", "type": "external" } ], "gene_names_uniprotkb": "Dvl3", "gene_names_refseq": "Dvl3", "protein_names_uniprotkb": "Dishevelled segment polarity protein 3", "protein_names_refseq": "segment polarity protein dishevelled homolog DVL-3 isoform X1", "tax_id": 10116, "disease": "autosomal dominant Robinow syndrome 3 (Disease Ontology:DOID:0060767); neurodegenerative disease (Disease Ontology:DOID:1289); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (R-RNO-201688); (R-RNO-4086400); (R-RNO-4641258); (R-RNO-4641262); (R-RNO-5663220)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "22673903", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005109 frizzled binding;GO:0031267 small GTPase binding;GO:0008013 beta-catenin binding;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005829 cytosol;GO:0000785 chromatin;GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0045202 synapse", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046330 positive regulation of JNK cascade;GO:0032880 regulation of protein localization;GO:0050821 protein stabilization;GO:0007264 small GTPase-mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D4ADV8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B2GV38-1", "uniprot_id": [ { "id": "UBL4A_RAT", "url": "https://www.uniprot.org/uniprot/B2GV38", "type": "external" } ], "mass": 17791.0, "length": 157, "protein_name": "Ubiquitin-like protein 4A", "gene_name": "Ubl4a", "organism": "Rat", "refseq_name": "ubiquitin-like protein 4A", "refseq_ac": [ { "id": "NP_001099816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099816", "type": "external" } ], "gene_names_uniprotkb": "Ubl4a; Ubl4", "gene_names_refseq": "RGD1563983; Ubl4a; Ubl4", "protein_names_uniprotkb": "Ubiquitin-like protein 4A", "protein_names_refseq": "ubiquitin-like 4; ubiquitin-like protein 4A", "tax_id": 10116, "disease": "", "pathway": " (rno:293864)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane;GO:0031647 regulation of protein stability;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0071816 tail-anchored membrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "B2GV38-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08950-1", "uniprot_id": [ { "id": "T2AG_RAT", "url": "https://www.uniprot.org/uniprot/O08950", "type": "external" } ], "mass": 12473.0, "length": 109, "protein_name": "Transcription initiation factor IIA subunit 2", "gene_name": "Gtf2a2", "organism": "Rat", "refseq_name": "transcription initiation factor IIA subunit 2", "refseq_ac": [ { "id": "NP_445797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445797", "type": "external" } ], "gene_names_uniprotkb": "Gtf2a2", "gene_names_refseq": "Gtf2a2", "protein_names_uniprotkb": "Transcription initiation factor IIA subunit 2; General transcription factor IIA subunit 2; TFIIA-gamma; Transcription initiation factor IIA gamma chain", "protein_names_refseq": "TFIIA-gamma; general transcription factor IIA subunit 2; general transcription factor IIa 2; general transcription factor IIa, 2 (12kD subunit); general transcription factor2A subunit 2; transcription initiation factor IIA gamma chain; transcription initiation factor IIA subunit 2", "tax_id": 10116, "disease": "", "pathway": " (rno:83828); (R-RNO-674695); (R-RNO-6807505); (R-RNO-73776); (R-RNO-73779); (R-RNO-75953); (R-RNO-76042); (R-RNO-9018519)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0017025 TBP-class protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005672 transcription factor TFIIA complex;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O08950-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24051-1", "uniprot_id": [ { "id": "RS27L_RAT", "url": "https://www.uniprot.org/uniprot/P24051", "type": "external" } ], "mass": 9477.0, "length": 84, "protein_name": "Small ribosomal subunit protein eS27-like", "gene_name": "LOC108353425; Rps27l3; Rps27l; Rps27", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS27-like", "refseq_ac": [ { "id": "NP_001263406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263406", "type": "external" } ], "gene_names_uniprotkb": "LOC108353425; Rps27l3; Rps27l; Rps27; LOC100362987; LOC100911728; Rps27l3; Rps27l; Rps27", "gene_names_refseq": "Rps27l1; Rps27l", "protein_names_uniprotkb": "Small ribosomal subunit protein eS27-like; 40S ribosomal protein S27-like", "protein_names_refseq": "40S ribosomal protein S27-like; ribosomal protein S27-like 1; ribosomal protein S27; small ribosomal subunit protein eS27-like", "tax_id": 10116, "disease": "Diamond-Blackfan anemia 17 (Disease Ontology:DOID:0111880)", "pathway": " (rno:100362987); (rno:681429); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "10820185;8441676", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0008494 translation activator activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0006412 translation;GO:0045727 positive regulation of translation;GO:0030330 DNA damage response, signal transduction by p53 class mediator;GO:0031571 mitotic G1 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P24051-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZB71-1", "uniprot_id": [ { "id": "D3ZB71_RAT", "url": "https://www.uniprot.org/uniprot/D3ZB71", "type": "external" } ], "mass": 78846.0, "length": 736, "protein_name": "Dishevelled segment polarity protein 2", "gene_name": "Dvl2", "organism": "Rat", "refseq_name": "segment polarity protein dishevelled homolog DVL-2", "refseq_ac": [ { "id": "NP_001165527", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165527", "type": "external" } ], "gene_names_uniprotkb": "Dvl2; LOC100361515", "gene_names_refseq": "Dvl-2; Dvl2", "protein_names_uniprotkb": "Dishevelled segment polarity protein 2", "protein_names_refseq": "segment polarity protein dishevelled homolog DVL-2", "tax_id": 10116, "disease": "", "pathway": " (rno:303251); (R-RNO-201688); (R-RNO-2028269); (R-RNO-4086400); (R-RNO-4608870); (R-RNO-4641258); (R-RNO-4641262); (R-RNO-5099900); (R-RNO-5663220); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 11, "publication_count": 4, "publication_id_list": "23396967;25825496;28187436;33577018", "class_list": "", "function": "Dpr1 promotes the ubiquitination of Dvl2 by pVHL and mediates the protein aggregate-elicited autophagy initiation, [RefSeq, PubMed]; MiR-29c-3p reduces bone loss in rats with diabetic osteoporosis via targeted regulation of Dvl2 expression., [RefSeq, PubMed]; Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis, [RefSeq, PubMed]; Wnt-induced dishevelled 2 phosphorylation has effects in in canonical and noncanonical Wnt3a and Wnt5a signaling, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0007507 heart development;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046330 positive regulation of JNK cascade;GO:0061098 positive regulation of protein tyrosine kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "D3ZB71-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3V7S6-1", "uniprot_id": [ { "id": "G3V7S6_RAT", "url": "https://www.uniprot.org/uniprot/G3V7S6", "type": "external" } ], "mass": 35922.0, "length": 339, "protein_name": "Hes-related family bHLH transcription factor with YRPW motif 2", "gene_name": "Hey2", "organism": "Rat", "refseq_name": "hairy/enhancer-of-split related with YRPW motif protein 2", "refseq_ac": [ { "id": "NP_569101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569101", "type": "external" } ], "gene_names_uniprotkb": "Hey2", "gene_names_refseq": "Herp1; Hey2", "protein_names_uniprotkb": "Hes-related family bHLH transcription factor with YRPW motif 2", "protein_names_refseq": "hairy/enhancer-of-split related with YRPW motif 2; hairy/enhancer-of-split related with YRPW motif protein 2", "tax_id": 10116, "disease": "hemangiopericytoma (Disease Ontology:DOID:264); aortic valve disease (Disease Ontology:DOID:62); tetralogy of Fallot (Disease Ontology:DOID:6419); varicose veins (Disease Ontology:DOID:799)", "pathway": " (rno:155430)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0072359 circulatory system development;GO:0003171 atrioventricular valve development;GO:0003208 cardiac ventricle morphogenesis;GO:0003195 tricuspid valve formation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3V7S6-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O09139-1", "uniprot_id": [ { "id": "E2F1_RAT", "url": "https://www.uniprot.org/uniprot/O09139", "type": "external" } ], "mass": 46548.0, "length": 432, "protein_name": "Transcription factor E2F1", "gene_name": "E2f1; Necab3", "organism": "Rat", "refseq_name": "transcription factor E2F1", "refseq_ac": [ { "id": "NP_001094248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094248", "type": "external" } ], "gene_names_uniprotkb": "E2f1; Necab3; Necab3", "gene_names_refseq": "E2f1", "protein_names_uniprotkb": "Transcription factor E2F1; E2F-1", "protein_names_refseq": "E2F-1; transcription factor E2F1", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); Huntington's disease (Disease Ontology:DOID:12858); Sjogren's syndrome (Disease Ontology:DOID:12894); dementia (Disease Ontology:DOID:1307); pancreatic cancer (Disease Ontology:DOID:1793); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); osteosarcoma (Disease Ontology:DOID:3347); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); lung small cell carcinoma (Disease Ontology:DOID:5409); viral encephalitis (Disease Ontology:DOID:646); chronic myeloid leukemia (Disease Ontology:DOID:8552); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:311562); (rno:399489); (R-RNO-68911); (R-RNO-69231)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "20176812;29936143;34342400;35457270;36111777;37403456;8673024", "class_list": "", "function": "Biological effects of miRNA-24/E2F1 on myocardial ischemia-reperfusion injury., [RefSeq, PubMed]; E2F1 Expression and Apoptosis Initiation in Crayfish and Rat Peripheral Neurons and Glial Cells after Axonal Injury. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3., [UniProtKB, UniProtKB]; SENP5 deteriorates traumatic brain injury via SUMO2-dependent suppression of E2F1 SUMOylation., [RefSeq, PubMed]; Spherical alpha-helical polypeptide-mediated E2F1 silencing against myocardial ischemia-reperfusion injury (MIRI). Publication Status: Online-Only, [RefSeq, PubMed]; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Directly activates transcription of PEG10. Positively regulates transcription of RRP1B., [UniProtKB, UniProtKB]; Two novel alternatively spliced E2F1 transcripts were identified in rat hippocampus., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0070345 negative regulation of fat cell proliferation;GO:1990086 lens fiber cell apoptotic process;GO:0060252 positive regulation of glial cell proliferation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O09139-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35913-1", "uniprot_id": [ { "id": "SO1A4_RAT", "url": "https://www.uniprot.org/uniprot/O35913", "type": "external" } ], "mass": 73252.0, "length": 661, "protein_name": "Solute carrier organic anion transporter family member 1A4", "gene_name": "Slco1a4; Slco1a5; Slco1a8", "organism": "Rat", "refseq_name": "solute carrier organic anion transporter family member 1A4", "refseq_ac": [ { "id": "NP_571981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571981", "type": "external" } ], "gene_names_uniprotkb": "Slco1a4; Slco1a5; Slco1a8; Oatp1a4; Oatp2; Slc21a4; Slc21a5; Slco1a3; Slco1a4; Slco1a5; Slco1a8", "gene_names_refseq": "Oatp2; Slc21a5; Slco1a2; Slco1a4", "protein_names_uniprotkb": "Solute carrier organic anion transporter family member 1A4; Brain digoxin carrier protein; Brain-specific organic anion transporter; OATP-B1; Sodium-independent organic anion-transporting polypeptide 2; Solute carrier family 21 member 5", "protein_names_refseq": "OATP-B1; brain digoxin carrier protein; brain-specific organic anion transporter; organic anion transporter 2; sodium-independent organic anion-transporting polypeptide 2; solute carrier family 21 (organic anion transporter), member 5; solute carrier family 21 member 5; solute carrier organic anion transporter family member 1A4; solute carrier organic anion transporter family, member 1A2", "tax_id": 10116, "disease": "Dubin-Johnson syndrome (Disease Ontology:DOID:12308); cholestasis (Disease Ontology:DOID:13580); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (rno:170698); (R-RNO-159418); (R-RNO-879518); (R-RNO-9793528)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "19129463;30977661;31102415;31174976;31746415;33779805;9294213;9712861", "class_list": "", "function": "Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, prostaglandin E2, estrone 3-sulfate, L-thyroxine (T4), the cardiac glycosides ouabain and digoxin and thyroid hormones (PubMed:19129463). May play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides. Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463)., [UniProtKB, PubMed]; MiR-23a-3p is involved in drug resistance by directly targeting the influx drug transporter organic anion-transporting polypeptide 2., [RefSeq, PubMed]; Oatp1a4 appears to play a major role in Cerebrospinal Fluid detoxification by limiting the distribution of organic anions to the brain and spinal cord., [RefSeq, PubMed]; Optimal rOATP1A4 trafficking to the cell surface is dependent upon coexpression and interaction with rOATP1A1., [RefSeq, PubMed]; Organic anion transporting polypeptide 1A2 mediates fentanyl uptake in cultured cells., [RefSeq, PubMed]; The Oatp1a4 function is dominant in the region around the hepatic CV in rat hepatic lobules., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O55224", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015125 bile acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015721 bile acid and bile salt transport;GO:0071466 cellular response to xenobiotic stimulus;GO:0043627 response to estrogen;GO:0043252 sodium-independent organic anion transport;GO:0006820 monoatomic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O35913-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97698-1", "uniprot_id": [ { "id": "SMO_RAT", "url": "https://www.uniprot.org/uniprot/P97698", "type": "external" } ], "mass": 87376.0, "length": 793, "protein_name": "Protein smoothened", "gene_name": "Smo", "organism": "Rat", "refseq_name": "protein smoothened precursor", "refseq_ac": [ { "id": "NP_036939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036939", "type": "external" } ], "gene_names_uniprotkb": "Smo", "gene_names_refseq": "Smoh; Smo", "protein_names_uniprotkb": "Protein smoothened", "protein_names_refseq": "protein smoothened precursor; protein smoothened; smoothened protein; smoothened, frizzled family receptor", "tax_id": 10116, "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); medulloblastoma (Disease Ontology:DOID:0050902); pre-malignant neoplasm (Disease Ontology:DOID:0060071); stomach cancer (Disease Ontology:DOID:10534); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus adenocarcinoma (Disease Ontology:DOID:4914); pancreatitis (Disease Ontology:DOID:4989); liver cirrhosis (Disease Ontology:DOID:5082); gastric papillary adenocarcinoma (Disease Ontology:DOID:5593); gastric tubular adenocarcinoma (Disease Ontology:DOID:6595); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); malignant pleural mesothelioma (Disease Ontology:DOID:7474); Barrett's esophagus (Disease Ontology:DOID:9206); colorectal cancer (Disease Ontology:DOID:9256); ocular hypertension (Disease Ontology:DOID:9282); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (rno:25273); (R-RNO-5610787); (R-RNO-5620922); (R-RNO-5632684); (R-RNO-5635838)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "34755677;36946310;37516284;8906787", "class_list": "", "function": "Enhancement of biochemical and genomic pathways through lycopene-loaded nano-liposomes: Alleviating insulin resistance, hepatic steatosis, and autophagy in obese rats with non-alcoholic fatty liver disease: Involvement of SMO, GLI-1, and PTCH-1 genes., [RefSeq, PubMed]; G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling. Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched. When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes. Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation., [UniProtKB, UniProtKB]; G protein-coupled receptor, which transduces the smoothened signaling pathway. Activated by cholesterol in response to hedgehog (DHH, IHH or SHH) morphogens. In absence of hedgehog, SMO is inactivated by patched protein (PTCH1 or PTCH2), which prevents SMO access to cholesterol. In response to hedgehog-binding to pathched, inhibition is relieved, promoting SMO translocation to primary cilium and activation by cholesterol: cholesterol causes a conformation change that triggers signaling via G protein G(i), mediating inhibition of adenylate cyclase activity and decreassed production of cAMP. Decreased cAMP levels then inhibit protein kinase A (PKA) and promote release of GLI (GLI1, GLI2 and GLI3) transcription factors, which activate expression of target genes. Active SMO also directly inhibits PKA by sequestering its catalytic subunit, PRKACA, at the cell membrane, preventing PRKACA-mediated phosphorylation and subsequent processing of GLI transcription factors (By similarity). Active SMO also promotes the removal of GPR161, a key inhibitor of the smoothened signaling pathway, from primary cilia (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MiR-6315 silencing protects against spinal cord injury through the Smo and anti-ferroptosis pathway., [RefSeq, PubMed]; [G-protein coupled receptor Smo positively regulates proliferation and migration of adult neural stem cells in vitro]., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0005113 patched binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0060242 contact inhibition;GO:0001708 cell fate specification;GO:0045880 positive regulation of smoothened signaling pathway;GO:0003140 determination of left/right asymmetry in lateral mesoderm", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P97698-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15709-1", "uniprot_id": [ { "id": "ST2A1_RAT", "url": "https://www.uniprot.org/uniprot/P15709", "type": "external" } ], "mass": 33135.0, "length": 284, "protein_name": "Sulfotransferase 2A1", "gene_name": "LOC120099768; Sult2a1; Sult2a2; Sult2a6", "organism": "Rat", "refseq_name": "sulfotransferase 2A1", "refseq_ac": [ { "id": "NP_571978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_571978", "type": "external" } ], "gene_names_uniprotkb": "LOC120099768; Sult2a1; Sult2a2; Sult2a6; LOC100364224; LOC120099768; LOC134485278; St2a1; Sult2a1; Sult2a2", "gene_names_refseq": "STa; Smp-2; St2a1; St2; Sth2; Sult2a1", "protein_names_uniprotkb": "Sulfotransferase 2A1; 2.8.2.14; 2.8.2.2; Bile salt sulfotransferase; Hydroxysteroid sulfotransferase; ST-20; ST2A1; ST", "protein_names_refseq": "ST-20; ST; alcohol sulfotransferase; bile salt sulfotransferase; bile-salt sulfotransferase 2A1; hydroxysteroid sulfotransferase a; hydroxysteroid sulfotransferase-like; sulfotransferase 2A1; sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1; sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1; sulfotransferase hydroxysteroid gene 2; sulfotransferase, hydroxysteroid preferring 2", "tax_id": 10116, "disease": "prostate cancer (Disease Ontology:DOID:10283)", "pathway": " (rno:24912); (R-RNO-156584); (R-RNO-9753281)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "21721019;23026138;2590219;7854148;8033273", "class_list": "", "function": "Data suggest that Sult2a1 and Sult1a1 can be induced in small intestinal mucosa by dietary factors (here, by various levels of caffeine); induction is gender specific and organ specific. Consumption of caffeine may enhance xenobiotic detoxification., [RefSeq, PubMed]; Results suggest that the physiological functions of SULT2A1 in different brain regions can be affected by methamphetamine., [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (By similarity). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (PubMed:7854148)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0G2JYC0", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.14", "type": "external" }, { "id": "2.8.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.2", "type": "external" }, { "id": "2.8.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.1", "type": "external" }, { "id": "2.8.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.4", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0004027 alcohol sulfotransferase activity;GO:0047704 bile-salt sulfotransferase activity;GO:0050294 steroid sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051923 sulfation;GO:0008203 cholesterol metabolic process;GO:0031667 response to nutrient levels;GO:0006068 ethanol catabolic process;GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P15709-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9T8-1", "uniprot_id": [ { "id": "TBB4B_RAT", "url": "https://www.uniprot.org/uniprot/Q6P9T8", "type": "external" } ], "mass": 49801.0, "length": 445, "protein_name": "Tubulin beta-4B chain", "gene_name": "Tubb4b; Tubb6", "organism": "Rat", "refseq_name": "tubulin beta-4B chain", "refseq_ac": [ { "id": "NP_954525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954525", "type": "external" } ], "gene_names_uniprotkb": "Tubb4b; Tubb6; Tubb2c; Tubb4b", "gene_names_refseq": "Tubb2c; Tubb2; Tubb4b", "protein_names_uniprotkb": "Tubulin beta-4B chain; Tubulin beta-2C chain", "protein_names_refseq": "tubulin beta-2C chain; tubulin beta-4B chain; tubulin, beta 2C; tubulin, beta, 2", "tax_id": 10116, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); tubulinopathy (Disease Ontology:DOID:0112227); Leber congenital amaurosis with early-onset deafness (Disease Ontology:DOID:0112240); facial paralysis (Disease Ontology:DOID:13934)", "pathway": " (rno:296554); (rno:307351); (R-RNO-190840); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-2565942); (R-RNO-3371497); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-437239); (R-RNO-5610787); (R-RNO-5620912); (R-RNO-5620920); (R-RNO-5620924); (R-RNO-5626467); (R-RNO-5663220); (R-RNO-6798695); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8852276); (R-RNO-8854518); (R-RNO-8955332); (R-RNO-9646399); (R-RNO-9648025); (R-RNO-9668328); (R-RNO-983189); (R-RNO-9833482)", "pathway_count": 32, "publication_count": 4, "publication_id_list": "18683930;22673903;34502162;38843836", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0033269 internode region of axon;GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030317 flagellated sperm motility;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6P9T8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63562-1", "uniprot_id": [ { "id": "M3K8_RAT", "url": "https://www.uniprot.org/uniprot/Q63562", "type": "external" } ], "mass": 52807.0, "length": 467, "protein_name": "Mitogen-activated protein kinase kinase kinase 8", "gene_name": "Map3k8", "organism": "Rat", "refseq_name": "mitogen-activated protein kinase kinase kinase 8", "refseq_ac": [ { "id": "NP_446299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446299", "type": "external" } ], "gene_names_uniprotkb": "Map3k8; Tpl2", "gene_names_refseq": "D17TPL2; Map3k8; Tpl-2; Tpl2", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 8; 2.7.11.25; TPL-2; Tumor progression locus 2", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase 8; serine/threonine kinase (Tpl-2); tumor progression locus 2", "tax_id": 10116, "disease": "stomach cancer (Disease Ontology:DOID:10534); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); lung non-small cell carcinoma (Disease Ontology:DOID:3908); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (rno:116596); (R-RNO-389357); (R-RNO-5684264)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "22673903;7681591;9950430", "class_list": "", "function": "Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0004709 MAP kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0003231 cardiac ventricle development;GO:0000165 MAPK cascade;GO:0050729 positive regulation of inflammatory response;GO:0002376 immune system process;GO:1990349 gap junction-mediated intercellular transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q63562-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34900-1", "uniprot_id": [ { "id": "SDC2_RAT", "url": "https://www.uniprot.org/uniprot/P34900", "type": "external" } ], "mass": 22149.0, "length": 201, "protein_name": "Syndecan-2", "gene_name": "Sdc2", "organism": "Rat", "refseq_name": "syndecan-2 precursor", "refseq_ac": [ { "id": "NP_037214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037214", "type": "external" } ], "gene_names_uniprotkb": "Sdc2; Hspg1; Synd2", "gene_names_refseq": "HSPG; Sdc2", "protein_names_uniprotkb": "Syndecan-2; Fibroglycan; HSPG; Heparan sulfate proteoglycan core protein; SYND2", "protein_names_refseq": "Ryudocan/syndecan 2; SYND2; fibroglycan; heparan sulfate proteoglycan core protein; syndecan-2 precursor", "tax_id": 10116, "disease": "cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:25615); (R-RNO-1971475); (R-RNO-2022928); (R-RNO-2024096); (R-RNO-3000170); (R-RNO-381426); (R-RNO-3928662); (R-RNO-8957275); (R-RNO-975634); (R-RNO-9769739)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "1740437;27627962;28821612", "class_list": "", "function": "Cell surface proteoglycan which regulates dendritic arbor morphogenesis., [UniProtKB, UniProtKB]; Cell surface proteoglycan., [UniProtKB, UniProtKB]; Data suggest that the cytoplasmic domain of Sdc2 is involved in regulation of expression of MMP7 in colon carcinoma/adenocarcinoma cells; induction of MMP7 involves protein kinase C gamma-mediated FAK/ERK signaling. (Sdc2 = syndecan-2; MMP7 = matrix metalloproteinase-7; FAK = focal adhesion kinase 1), [RefSeq, PubMed]; Postsynaptic SDC2 uses its ectodomain to interact with and facilitate dendritic filopodial targeting of FGF22, triggering presynaptic maturation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030165 PDZ domain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043025 neuronal cell body;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0016477 cell migration;GO:0045785 positive regulation of cell adhesion;GO:0048814 regulation of dendrite morphogenesis;GO:0001666 response to hypoxia;GO:0031000 response to caffeine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P34900-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P69897-1", "uniprot_id": [ { "id": "TBB5_RAT", "url": "https://www.uniprot.org/uniprot/P69897", "type": "external" } ], "mass": 49671.0, "length": 444, "protein_name": "Tubulin beta-5 chain", "gene_name": "Tubb5", "organism": "Rat", "refseq_name": "tubulin beta-5 chain", "refseq_ac": [ { "id": "NP_775125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775125", "type": "external" } ], "gene_names_uniprotkb": "Tubb5", "gene_names_refseq": "Tubb5; Tubb", "protein_names_uniprotkb": "Tubulin beta-5 chain", "protein_names_refseq": "tubulin beta-5 chain", "tax_id": 10116, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); complex cortical dysplasia with other brain malformations 6 (Disease Ontology:DOID:0090136); tubulinopathy (Disease Ontology:DOID:0112227); congenital symmetric circumferential skin creases 1 (Disease Ontology:DOID:0112242); microcephaly (Disease Ontology:DOID:10907); facial paralysis (Disease Ontology:DOID:13934)", "pathway": " (rno:29214); (R-RNO-2565942); (R-RNO-380259); (R-RNO-380270); (R-RNO-380284); (R-RNO-380320); (R-RNO-5620912); (R-RNO-6798695); (R-RNO-8854518)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "10524766;15060004;18047804;22309793;22673903;34502162;38843836", "class_list": "", "function": "Coimmunoprecipitation experiments of transfected cells revealed that rat TRPV4 and rat tubulin beta 5 associated together in a complex., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05218;Q6P9X8;Q8WUC1;Q9CY33", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0051225 spindle assembly;GO:0071895 odontoblast differentiation;GO:0050807 regulation of synapse organization", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P69897-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P85108-1", "uniprot_id": [ { "id": "TBB2A_RAT", "url": "https://www.uniprot.org/uniprot/P85108", "type": "external" } ], "mass": 49907.0, "length": 445, "protein_name": "Tubulin beta-2A chain", "gene_name": "Tubb2a; Tubb2b", "organism": "Rat", "refseq_name": "tubulin beta-2A chain", "refseq_ac": [ { "id": "NP_001102589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102589", "type": "external" } ], "gene_names_uniprotkb": "Tubb2a; Tubb2b; Tubb2b", "gene_names_refseq": "Tubb2a; Tubb2b", "protein_names_uniprotkb": "Tubulin beta-2A chain", "protein_names_refseq": "T beta-15; Tubulin beta-2B chain; tubulin beta-2A chain pseudogene; tubulin beta-2A chain", "tax_id": 10116, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); complex cortical dysplasia with other brain malformations 5 (Disease Ontology:DOID:0090135); tubulinopathy (Disease Ontology:DOID:0112227); facial paralysis (Disease Ontology:DOID:13934)", "pathway": " (rno:498736); (R-RNO-190840); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3371497); (R-RNO-380320); (R-RNO-437239); (R-RNO-5610787); (R-RNO-5620920); (R-RNO-5620924); (R-RNO-5626467); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8852276); (R-RNO-8955332); (R-RNO-9646399); (R-RNO-9648025); (R-RNO-9668328); (R-RNO-983189); (R-RNO-9833482)", "pathway_count": 24, "publication_count": 2, "publication_id_list": "18683930;38843836", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton;GO:0097229 sperm end piece;GO:0045171 intercellular bridge", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0001764 neuron migration;GO:0021987 cerebral cortex development;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P85108-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4QRB4-1", "uniprot_id": [ { "id": "TBB3_RAT", "url": "https://www.uniprot.org/uniprot/Q4QRB4", "type": "external" } ], "mass": 50419.0, "length": 450, "protein_name": "Tubulin beta-3 chain", "gene_name": "Tubb3", "organism": "Rat", "refseq_name": "tubulin beta-3 chain", "refseq_ac": [ { "id": "NP_640347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_640347", "type": "external" } ], "gene_names_uniprotkb": "Tubb3", "gene_names_refseq": "Tubb3", "protein_names_uniprotkb": "Tubulin beta-3 chain; Neuron-specific class III beta-tubulin", "protein_names_refseq": "neuron-specific class III beta-tubulin; tubulin beta-3 chain", "tax_id": 10116, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); congenital fibrosis of the extraocular muscles (Disease Ontology:DOID:0080143); congenital fibrosis of the extraocular muscles 3A (Disease Ontology:DOID:0081017); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); complex cortical dysplasia with other brain malformations 1 (Disease Ontology:DOID:0090137); tubulinopathy (Disease Ontology:DOID:0112227); facial paralysis (Disease Ontology:DOID:13934)", "pathway": " (rno:246118); (R-RNO-190840); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3371497); (R-RNO-380320); (R-RNO-437239); (R-RNO-5610787); (R-RNO-5620920); (R-RNO-5620924); (R-RNO-5626467); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8852276); (R-RNO-8955332); (R-RNO-9646399); (R-RNO-9648025); (R-RNO-9668328); (R-RNO-983189); (R-RNO-9833482)", "pathway_count": 24, "publication_count": 5, "publication_id_list": "12234689;18683930;26561800;28223217;38843836", "class_list": "", "function": "PAX3 could inhibit the neuronal differentiation of neural stem celland the expression of TUBB3., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity). Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (By similarity). TUBB3 plays a critical role in proper axon guidance and maintenance (By similarity). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity)., [UniProtKB, UniProtKB]; Upon ependymal stem cells differentiation, Cx50 expression favors glial cell fate, since higher expression levels, endogenous or by over-expression of Cx50, augmented the expression of the astrocyte marker GFAP and impaired the neuronal marker Tubb3. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8K5B6", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0042277 peptide binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0030027 lamellipodium;GO:0030424 axon", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization;GO:0007411 axon guidance;GO:0038007 netrin-activated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q4QRB4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AY56-1", "uniprot_id": [ { "id": "TBA8_RAT", "url": "https://www.uniprot.org/uniprot/Q6AY56", "type": "external" } ], "mass": 50037.0, "length": 449, "protein_name": "Tubulin alpha-8 chain", "gene_name": "Tuba8", "organism": "Rat", "refseq_name": "tubulin alpha-8 chain", "refseq_ac": [ { "id": "NP_001019510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019510", "type": "external" } ], "gene_names_uniprotkb": "Tuba8", "gene_names_refseq": "Tuba8", "protein_names_uniprotkb": "Tubulin alpha-8 chain; 3.6.5.-; Alpha-tubulin 8", "protein_names_refseq": "alpha-tubulin 8; tubulin alpha-8 chain", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); autosomal dominant isolated macrothrombocytopenia 2 (Disease Ontology:DOID:0060995); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234)", "pathway": " (rno:500377); (R-RNO-190840); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3371497); (R-RNO-380320); (R-RNO-437239); (R-RNO-5620920); (R-RNO-5626467); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8852276); (R-RNO-8955332); (R-RNO-9646399); (R-RNO-9648025); (R-RNO-9668328); (R-RNO-983189); (R-RNO-9833482)", "pathway_count": 22, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.108", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0045121 membrane raft;GO:0015630 microtubule cytoskeleton;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007283 spermatogenesis;GO:0007286 spermatid development;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6AY56-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AYZ1-1", "uniprot_id": [ { "id": "TBA1C_RAT", "url": "https://www.uniprot.org/uniprot/Q6AYZ1", "type": "external" } ], "mass": 49937.0, "length": 449, "protein_name": "Tubulin alpha-1C chain", "gene_name": "Tuba1c", "organism": "Rat", "refseq_name": "tubulin alpha-1C chain", "refseq_ac": [ { "id": "NP_001011995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011995", "type": "external" } ], "gene_names_uniprotkb": "Tuba1c; Tuba6", "gene_names_refseq": "Tuba1c; Tuba6", "protein_names_uniprotkb": "Tubulin alpha-1C chain; 3.6.5.-; Alpha-tubulin 6; Tubulin alpha-6 chain", "protein_names_refseq": "alpha-tubulin 6; tubulin alpha-1C chain-like; tubulin alpha-1C chain; tubulin alpha-6 chain; tubulin, alpha 6", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234)", "pathway": " (rno:300218); (R-RNO-190840); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3371497); (R-RNO-380320); (R-RNO-437239); (R-RNO-5610787); (R-RNO-5620920); (R-RNO-5620924); (R-RNO-5626467); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8852276); (R-RNO-8955332); (R-RNO-9646399); (R-RNO-9648025); (R-RNO-9668328); (R-RNO-983189); (R-RNO-9833482)", "pathway_count": 24, "publication_count": 3, "publication_id_list": "29393594;38843836;9108330", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.108", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0045121 membrane raft", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6AYZ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6P9V9-1", "uniprot_id": [ { "id": "TBA1B_RAT", "url": "https://www.uniprot.org/uniprot/Q6P9V9", "type": "external" } ], "mass": 50152.0, "length": 451, "protein_name": "Tubulin alpha-1B chain", "gene_name": "Tuba1b", "organism": "Rat", "refseq_name": "tubulin alpha-1B chain", "refseq_ac": [ { "id": "NP_001037735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001037735", "type": "external" } ], "gene_names_uniprotkb": "Tuba1b; Tuba2", "gene_names_refseq": "RGD1565476; Tuba1b; Tuba1", "protein_names_uniprotkb": "Tubulin alpha-1B chain; 3.6.5.-; Alpha-tubulin 2; Tubulin alpha-2 chain", "protein_names_refseq": "Alpha-tubulin 1; Tubulin alpha-1 chain; alpha-tubulin 2; tubulin alpha-1B chain; tubulin alpha-2 chain", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234)", "pathway": " (rno:500929); (R-RNO-190840); (R-RNO-2132295); (R-RNO-2467813); (R-RNO-2500257); (R-RNO-3371497); (R-RNO-380320); (R-RNO-437239); (R-RNO-5610787); (R-RNO-5620920); (R-RNO-5620924); (R-RNO-5626467); (R-RNO-5663220); (R-RNO-6807878); (R-RNO-6811434); (R-RNO-6811436); (R-RNO-68877); (R-RNO-8852276); (R-RNO-8955332); (R-RNO-9013407); (R-RNO-9646399); (R-RNO-9648025); (R-RNO-9668328); (R-RNO-983189); (R-RNO-9833482)", "pathway_count": 25, "publication_count": 3, "publication_id_list": "34274903;34502162;9108330", "class_list": "", "function": "Lower levels of tubulin alpha 1b in the frontal pole in schizophrenia supports a role for changed cytoskeletal dynamics in the aetiology of the disorder., [RefSeq, PubMed]; Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (By similarity). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.3", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "6.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.1.108", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.108", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium;GO:0045121 membrane raft;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization;GO:0071353 cellular response to interleukin-4", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6P9V9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04644-1", "uniprot_id": [ { "id": "RS17_RAT", "url": "https://www.uniprot.org/uniprot/P04644", "type": "external" } ], "mass": 15510.0, "length": 135, "protein_name": "Small ribosomal subunit protein eS17", "gene_name": "LOC100362366; Rps17l1; Rps17l4; Rps17", "organism": "Rat", "refseq_name": "small ribosomal subunit protein eS17", "refseq_ac": [ { "id": "NP_058848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058848", "type": "external" } ], "gene_names_uniprotkb": "LOC100362366; Rps17l1; Rps17l4; Rps17; LOC100362366; LOC100365810; LOC108352780; RGD1562381; Rps17l2", "gene_names_refseq": "Rps17", "protein_names_uniprotkb": "Small ribosomal subunit protein eS17; 40S ribosomal protein S17", "protein_names_refseq": "40S ribosomal protein S17; small ribosomal subunit protein eS17", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); Diamond-Blackfan anemia 4 (Disease Ontology:DOID:0111890); Diamond-Blackfan anemia (Disease Ontology:DOID:1339)", "pathway": " (rno:100362366); (rno:29286); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "3840111", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6PDV2", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0034101 erythrocyte homeostasis;GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P04644-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17078-1", "uniprot_id": [ { "id": "RL35_RAT", "url": "https://www.uniprot.org/uniprot/P17078", "type": "external" } ], "mass": 14553.0, "length": 123, "protein_name": "Large ribosomal subunit protein uL29", "gene_name": "LOC120093238; Rpl35l1; Rpl35", "organism": "Rat", "refseq_name": "large ribosomal subunit protein uL29", "refseq_ac": [ { "id": "NP_997676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997676", "type": "external" } ], "gene_names_uniprotkb": "LOC120093238; Rpl35l1; Rpl35; AABR07031666.1; LOC120093238; LOC686074; Rpl35l1", "gene_names_refseq": "Rpl35", "protein_names_uniprotkb": "Large ribosomal subunit protein uL29; 60S ribosomal protein L35", "protein_names_refseq": "60S ribosomal protein L35; large ribosomal subunit protein uL29", "tax_id": 10116, "disease": "Diamond-Blackfan anemia 19 (Disease Ontology:DOID:0111886)", "pathway": " (rno:120093238); (rno:296709); (rno:686074); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 3, "publication_id_list": "2322279;29393594;38843836", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0043021 ribonucleoprotein complex binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0002181 cytoplasmic translation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P17078-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0I8-1", "uniprot_id": [ { "id": "PI42A_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0I8", "type": "external" } ], "mass": 46210.0, "length": 406, "protein_name": "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha", "gene_name": "AABR07028769.1; Pip4k2a", "organism": "Rat", "refseq_name": "phosphatidylinositol 5-phosphate 4-kinase type-2 alpha", "refseq_ac": [ { "id": "NP_446378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446378", "type": "external" } ], "gene_names_uniprotkb": "AABR07028769.1; Pip4k2a; Pip4k2a; Pip4ka; Pip5k2a", "gene_names_refseq": "Pip4k2a; Pip5k2a", "protein_names_uniprotkb": "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; 2.7.1.149; Diphosphoinositide kinase 2-alpha; PI(5)P 4-kinase type II alpha; PIP4KII-alpha; PIPK2 alpha; Phosphatidylinositol 5-phosphate 4-kinase type II alpha; PtdIns(5)P-4-kinase isoform 2-alpha", "protein_names_refseq": "1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; 1-phosphatidylinositol-5-phosphate 4-kinase A; PI(5)P 4-kinase type II alpha; PIP4KII-alpha; PIPK2 alpha; diphosphoinositide kinase 2-alpha; phosphatidylinositol 5-phosphate 4-kinase type II alpha; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; phosphatidylinositol-4-phosphate 5-kinase, type II, alpha; phosphatidylinositol-5-phosphate 4-kinase type-2 alpha-like", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:116723); (R-RNO-1660499); (R-RNO-6811555); (R-RNO-6811558); (R-RNO-8847453)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "20204506;21847559", "class_list": "", "function": "Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Has both ATP- and GTP-dependent kinase activities. May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2 (By similarity). May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (PubMed:20204506). Required for lysosome-peroxisome membrane contacts and intracellular cholesterol transport through modulating peroxisomal PtdIns(4,5)P2 level (By similarity). In collaboration with PIP4K2B, has a role in mediating autophagy in times of nutrient stress (By similarity). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (By similarity). Negatively regulates insulin signaling through a catalytic-independent mechanism. PIP4Ks interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:21847559). May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.68", "type": "external" }, { "id": "2.7.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.149", "type": "external" } ], "go_molecular_function": "GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0010506 regulation of autophagy;GO:0035855 megakaryocyte development;GO:2000786 positive regulation of autophagosome assembly;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R0I8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P97633-1", "uniprot_id": [ { "id": "KC1A_RAT", "url": "https://www.uniprot.org/uniprot/P97633", "type": "external" } ], "mass": 37495.0, "length": 325, "protein_name": "Casein kinase I isoform alpha", "gene_name": "Csnk1a1", "organism": "Rat", "refseq_name": "casein kinase I isoform alpha", "refseq_ac": [ { "id": "NP_446067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446067", "type": "external" } ], "gene_names_uniprotkb": "Csnk1a1", "gene_names_refseq": "CK1; Csnk1a1", "protein_names_uniprotkb": "Casein kinase I isoform alpha; 2.7.11.1; CK1; CKI-alpha", "protein_names_refseq": "CKI-alpha; casein kinase I isoform alpha; casein kinase I", "tax_id": 10116, "disease": "syndromic X-linked intellectual disability Najm type (Disease Ontology:DOID:0060807); Alzheimer's disease (Disease Ontology:DOID:10652); inclusion body myositis (Disease Ontology:DOID:3429)", "pathway": " (rno:113927); (R-RNO-195253); (R-RNO-196299); (R-RNO-4641262); (R-RNO-5610785); (R-RNO-5635838); (R-RNO-69601)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "11955436;24760862;38843836;8973207", "class_list": "", "function": "CK1 associates with and phosphorylates REST at two neighboring, but distinct, motifs within the C terminus of REST critical for binding of beta-TrCP and targeting of REST for proteasomal degradation., [RefSeq, PubMed]; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity). Can phosphorylate a large number of proteins (By similarity). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (By similarity). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (By similarity). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97634", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0031670 cellular response to nutrient;GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P97633-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04666-1", "uniprot_id": [ { "id": "HES1_RAT", "url": "https://www.uniprot.org/uniprot/Q04666", "type": "external" } ], "mass": 29622.0, "length": 281, "protein_name": "Transcription factor HES-1", "gene_name": "Hes1", "organism": "Rat", "refseq_name": "transcription factor HES-1", "refseq_ac": [ { "id": "NP_077336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077336", "type": "external" } ], "gene_names_uniprotkb": "Hes1; Hes-1; Hl", "gene_names_refseq": "Hes1", "protein_names_uniprotkb": "Transcription factor HES-1; Hairy and enhancer of split 1; Hairy-like protein; RHL", "protein_names_refseq": "RHL; hairy and enhancer of split 1; hairy-like protein; transcription factor HES-1", "tax_id": 10116, "disease": "brain cancer (Disease Ontology:DOID:1319); epilepsy (Disease Ontology:DOID:1826); hemangiopericytoma (Disease Ontology:DOID:264); acute kidney failure (Disease Ontology:DOID:3021); central nervous system cancer (Disease Ontology:DOID:3620); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (rno:29577)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "1340473;22302822;31454988;31476403;37445785;37543138;8417318;8649374;8687460", "class_list": "", "function": "KDM6B Negatively Regulates the Neurogenesis Potential of Apical Papilla Stem Cells via HES1. Publication Status: Online-Only, [RefSeq, PubMed]; Penehyclidine hydrochloride alleviates LPS-induced ALI by ameliorating ER stress-mediated apoptosis and promoting Hes1/Notch1 signaling in vivo and in vitro., [RefSeq, PubMed]; The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model., [RefSeq, PubMed]; The results in this study indicated nerve injury diminishes spinal Hes1-dependent suppression of CDK9-dependent RNAPII phosphorylation on the mGluR5 promoter that possibly enhances mGluR5 transcription/expression for neuropathic pain development. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0000785 chromatin", "go_biological_process": "GO:0043279 response to alkaloid;GO:1904010 response to Aroclor 1254;GO:2000981 negative regulation of inner ear receptor cell differentiation;GO:0021984 adenohypophysis development;GO:0045608 negative regulation of inner ear auditory receptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q04666-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924Z9-1", "uniprot_id": [ { "id": "NET1_RAT", "url": "https://www.uniprot.org/uniprot/Q924Z9", "type": "external" } ], "mass": 67873.0, "length": 604, "protein_name": "Netrin-1", "gene_name": "Ntn1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Ntn1", "gene_names_refseq": "", "protein_names_uniprotkb": "Netrin-1", "protein_names_refseq": "", "tax_id": 10116, "disease": "mirror movements 4 (Disease Ontology:DOID:0070638)", "pathway": " (rno:114523)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11356879;8861902", "class_list": "", "function": "Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0060603 mammary gland duct morphogenesis;GO:0007409 axonogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0016358 dendrite development;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q924Z9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q63450-1", "uniprot_id": [ { "id": "KCC1A_RAT", "url": "https://www.uniprot.org/uniprot/Q63450", "type": "external" } ], "mass": 41638.0, "length": 374, "protein_name": "Calcium/calmodulin-dependent protein kinase type 1", "gene_name": "Camk1", "organism": "Rat", "refseq_name": "calcium/calmodulin-dependent protein kinase type 1", "refseq_ac": [ { "id": "NP_604463", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_604463", "type": "external" } ], "gene_names_uniprotkb": "Camk1", "gene_names_refseq": "Camk1; Camki; Gaip", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type 1; 2.7.11.17; CaM kinase I alpha; CaM kinase I; CaM-KI; CaMKI-alpha", "protein_names_refseq": "G alpha interacting protein; caM kinase I alpha; caM-KI; caMKI-alpha; calcium/calmodulin-dependent protein kinase type 1; regulator of G-protein signalling 19", "tax_id": 10116, "disease": "", "pathway": " (rno:171503); (R-RNO-9619229)", "pathway_count": 2, "publication_count": 26, "publication_id_list": "10400638;10936699;12081505;12475216;15084659;15147908;15689566;1646483;16772171;17022975;18683930;21107644;26386307;27323839;27369073;34875535;7624832;7698321;7948038;8253780;8386178;8601311;8621702;8631893;8702851;9405489", "class_list": "", "function": "C-terminal cytoplasmic fragment of PcdhgC5 acts as a scaffold for CaMKP and CaMKI to regulate CaMKP activity., [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-516', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation (By similarity). Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-275' and 'Ser-294'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Expression of CaMKIbeta2 in the retina was detected from the earliest development until adulthood, indicating that CaMKIbeta2 may be required in both proliferation and differentiation of the retinal precursor cells and subsequent formation of the functional layers Publication Status: Online-Only, [RefSeq, PubMed]; Furthermore, the effect of CaMKP on self-assembly of NFL was examined. Electron microscopy revealed that CaMKP markedly prevented NFL from forming large filamentous aggregates, suggesting that CaMKP-binding to NFL inhibits its filament association. These findings may provide new insights into a novel mechanism for regulating network formation of neurofilaments during neuronal differentiation., [RefSeq, PubMed]; Oligomerization of Ca(2+)/calmodulin-dependent protein kinase kinase., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q63084", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0014069 postsynaptic density", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006913 nucleocytoplasmic transport;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q63450-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8CGU6-1", "uniprot_id": [ { "id": "NICA_RAT", "url": "https://www.uniprot.org/uniprot/Q8CGU6", "type": "external" } ], "mass": 78400.0, "length": 708, "protein_name": "Nicastrin", "gene_name": "Ncstn", "organism": "Rat", "refseq_name": "nicastrin precursor", "refseq_ac": [ { "id": "NP_777353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777353", "type": "external" } ], "gene_names_uniprotkb": "Ncstn", "gene_names_refseq": "Ncstn", "protein_names_uniprotkb": "Nicastrin", "protein_names_refseq": "nicastrin precursor", "tax_id": 10116, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); vitiligo (Disease Ontology:DOID:12306); alcohol use disorder (Disease Ontology:DOID:1574); hidradenitis suppurativa (Disease Ontology:DOID:2280); schizophrenia (Disease Ontology:DOID:5419); chronic myeloid leukemia (Disease Ontology:DOID:8552)", "pathway": " (rno:289231); (R-RNO-1251985); (R-RNO-193692); (R-RNO-205043); (R-RNO-3928665); (R-RNO-6798695); (R-RNO-9013507); (R-RNO-9017802); (R-RNO-9839383)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "12736250;21454685;24090084;29176823;29393594;38843836", "class_list": "", "function": "Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Experiments establish amyloid precursor protein, nicastrin, and presenilin-1 as resident lysosomal membrane proteins and indicate that gamma-secretase is a lysosomal protease, [RefSeq, PubMed]; These results demonstrated the localization of VDR on the neuronal plasma membrane and the co-localization of VDR and APP or ADAM10 or Nicastrin and limited co-localization of VDR and PS1. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 15, "predicted_n_glycosites": 15, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 8, "disease_count": 7, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "Q8CH12", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0051117 ATPase binding;GO:0070851 growth factor receptor binding;GO:0008233 peptidase activity;GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing;GO:0007611 learning or memory;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q8CGU6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1100000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ERE0-1", "uniprot_id": [ { "id": "CCL17_RAT", "url": "https://www.uniprot.org/uniprot/Q9ERE0", "type": "external" } ], "mass": 10480.0, "length": 93, "protein_name": "C-C motif chemokine 17", "gene_name": "Ccl17", "organism": "Rat", "refseq_name": "C-C motif chemokine 17 precursor", "refseq_ac": [ { "id": "NP_476492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476492", "type": "external" } ], "gene_names_uniprotkb": "Ccl17; Abcd-2; Tarc", "gene_names_refseq": "Ccl17; Scya17; Tarc", "protein_names_uniprotkb": "C-C motif chemokine 17; CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine", "protein_names_refseq": "C-C motif chemokine 17 precursor; C-C motif chemokine 17; CC chemokine TARC; chemokine (C-C motif) ligand 17; small inducible cytokine subfamily A (Cys-Cys), member 17; small-inducible cytokine A17; thymus and activation-regulated chemokine", "tax_id": 10116, "disease": "sarcoidosis (Disease Ontology:DOID:11335); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); allergic bronchopulmonary aspergillosis (Disease Ontology:DOID:13166); cystic fibrosis (Disease Ontology:DOID:1485); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary fibrosis (Disease Ontology:DOID:3770); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); pneumonia (Disease Ontology:DOID:552); pulmonary eosinophilia (Disease Ontology:DOID:9498)", "pathway": " (rno:117518); (R-RNO-380108)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation (By similarity). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity;GO:0031729 CCR4 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0045662 negative regulation of myoblast differentiation;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9ERE0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21961-1", "uniprot_id": [ { "id": "CBPA3_RAT", "url": "https://www.uniprot.org/uniprot/P21961", "type": "external" } ], "mass": 47944.0, "length": 412, "protein_name": "Mast cell carboxypeptidase A", "gene_name": "Cpa3", "organism": "Rat", "refseq_name": "mast cell carboxypeptidase A precursor", "refseq_ac": [ { "id": "NP_062173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062173", "type": "external" } ], "gene_names_uniprotkb": "Cpa3", "gene_names_refseq": "Cpa3", "protein_names_uniprotkb": "Mast cell carboxypeptidase A; 3.4.17.1; Carboxypeptidase A3; R-CPA; RMC-CP", "protein_names_refseq": "R-CPA; RMC-CP; carboxypeptidase A3, mast cell; mast cell carboxypeptidase A precursor; mast cell carboxypeptidase A", "tax_id": 10116, "disease": "", "pathway": " (rno:54242); (R-RNO-2022377)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1988052;24953986;8996238", "class_list": "", "function": "These data suggest that ischemic preconditioning protected against reperfusion injury via the mast cell degranulation-mediated release of MC-CPA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P97597", "ec_number_list": [ { "id": "3.4.17.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.2", "type": "external" }, { "id": "3.4.17.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.1", "type": "external" }, { "id": "3.4.17.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.20", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030133 transport vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0002003 angiotensin maturation;GO:0002002 regulation of angiotensin levels in blood", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P21961-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPI1-1", "uniprot_id": [ { "id": "XYLT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPI1", "type": "external" } ], "mass": 93859.0, "length": 821, "protein_name": "Xylosyltransferase 1", "gene_name": "Xylt1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Xylt1", "gene_names_refseq": "", "protein_names_uniprotkb": "Xylosyltransferase 1; 2.4.2.26; Peptide O-xylosyltransferase 1; Xylosyltransferase I", "protein_names_refseq": "", "tax_id": 10116, "disease": "Desbuquois dysplasia (Disease Ontology:DOID:0060462); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); kidney disease (Disease Ontology:DOID:557); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:64133); (R-RNO-1971475)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11099377;38843836", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal maturation of chondrocytes during bone development, normal onset of ossification and normal embryonic and postnatal skeleton development, especially of the long bones., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.26", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030158 protein xylosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0000137 Golgi cis cisterna", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0034605 cellular response to heat;GO:0070555 response to interleukin-1;GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EPI1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000011000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R141-1", "uniprot_id": [ { "id": "S22A4_RAT", "url": "https://www.uniprot.org/uniprot/Q9R141", "type": "external" } ], "mass": 62362.0, "length": 553, "protein_name": "Solute carrier family 22 member 4", "gene_name": "Slc22a4", "organism": "Rat", "refseq_name": "solute carrier family 22 member 4", "refseq_ac": [ { "id": "NP_071606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071606", "type": "external" } ], "gene_names_uniprotkb": "Slc22a4; Octn1", "gene_names_refseq": "Octn1; Slc22a4", "protein_names_uniprotkb": "Solute carrier family 22 member 4; Octn1; Organic cation/carnitine transporter 1", "protein_names_refseq": "organic cation transporter OCTN1; organic cation/carnitine transporter 1; solute carrier family 22 (organic cation transporter), member 4; solute carrier family 22 (organic cation/zwitterion transporter), member 4; solute carrier family 22 member 4", "tax_id": 10116, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); rheumatoid arthritis (Disease Ontology:DOID:7148)", "pathway": " (rno:64037); (R-RNO-549127); (R-RNO-6798163)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10825452;17616214;18670092;35559956", "class_list": "", "function": "Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain. Publication Status: Online-Only, [RefSeq, PubMed]; Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations (PubMed:18670092). Functions as a Na(+)-dependent and pH-dependent high affinity microbial symporter of potent food-derived antioxidant ergothioeine (PubMed:18670092). Transports one sodium ion with one ergothioeine molecule (PubMed:18670092). Involved in the absorption of ergothioneine from the luminal/apical side of the small intestine and renal tubular cells, and into non-parenchymal liver cells, thereby contributing to maintain steady-state ergothioneine level in the body (By similarity). Also mediates the bidirectional transport of acetycholine, although the exact transport mechanism has not been fully identified yet (By similarity). Most likely exports anti-inflammatory acetylcholine in non-neuronal tissues, thereby contributing to the non-neuronal cholinergic system (By similarity). Displays a general physiological role linked to better survival by controlling inflammation and oxidative stress, which may be related to ergothioneine and acetycholine transports (By similarity). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (PubMed:17616214)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0015199 amino-acid betaine transmembrane transporter activity;GO:0005524 ATP binding;GO:0015171 amino acid transmembrane transporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0043025 neuronal cell body;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0006641 triglyceride metabolic process;GO:0032496 response to lipopolysaccharide;GO:0043330 response to exogenous dsRNA;GO:0007595 lactation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9R141-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZUL3-1", "uniprot_id": [ { "id": "D3ZUL3_RAT", "url": "https://www.uniprot.org/uniprot/D3ZUL3", "type": "external" } ], "mass": 109789.0, "length": 1034, "protein_name": "Collagen alpha-1(VI) chain", "gene_name": "Col6a1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Col6a1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(VI) chain", "protein_names_refseq": "", "tax_id": 10116, "disease": "Ullrich congenital muscular dystrophy (Disease Ontology:DOID:0050558); Bethlem myopathy (Disease Ontology:DOID:0050663); Ullrich congenital muscular dystrophy 1A (Disease Ontology:DOID:0060946); Bethlem myopathy 1A (Disease Ontology:DOID:0061198)", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "24090084", "class_list": "", "function": "Collagen VI acts as a cell-binding protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0097708 intracellular vesicle;GO:0005576 extracellular region;GO:0005739 mitochondrion;GO:0031012 extracellular matrix;GO:0005764 lysosome", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0060538 skeletal muscle organ development;GO:0010657 muscle cell apoptotic process;GO:0050954 sensory perception of mechanical stimulus;GO:0085029 extracellular matrix assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D3ZUL3-1", "record_type": "protein", "filter_code": "0000000.0000110.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11250-1", "uniprot_id": [ { "id": "RL34_RAT", "url": "https://www.uniprot.org/uniprot/P11250", "type": "external" } ], "mass": 13507.0, "length": 117, "protein_name": "Large ribosomal subunit protein eL34", "gene_name": "Rpl34", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rpl34; Rpl34l1; Rpl34l2", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein eL34; 60S ribosomal protein L34", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72689); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954709); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "2721685", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P11250-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54960-1", "uniprot_id": [ { "id": "CAPON_RAT", "url": "https://www.uniprot.org/uniprot/O54960", "type": "external" } ], "mass": 55864.0, "length": 503, "protein_name": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein", "gene_name": "C13h1orf226; Nos1ap", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "C13h1orf226; Nos1ap; C13h1orf226; Capon; LOC100361087; Nos1ap", "gene_names_refseq": "", "protein_names_uniprotkb": "Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Nitric oxide synthase 1 adaptor protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "nephrotic syndrome type 22 (Disease Ontology:DOID:0112268); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); depressive disorder (Disease Ontology:DOID:1596); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (rno:100361087); (rno:192363)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10623522;11086993;11867766;22673903;26197318;33523862;9459447", "class_list": "", "function": "Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 8, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0030165 PDZ domain binding;GO:0050998 nitric-oxide synthase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0098974 postsynaptic actin cytoskeleton organization;GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization;GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;GO:0031102 neuron projection regeneration;GO:0007269 neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O54960-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4AC54-1", "uniprot_id": [ { "id": "D4AC54_RAT", "url": "https://www.uniprot.org/uniprot/D4AC54", "type": "external" } ], "mass": 14292.0, "length": 134, "protein_name": "Uncharacterized protein", "gene_name": "AC133403.1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AC133403.1", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4AC54-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1M3B2-1", "uniprot_id": [ { "id": "F1M3B2_RAT", "url": "https://www.uniprot.org/uniprot/F1M3B2", "type": "external" } ], "mass": 123538.0, "length": 1143, "protein_name": "Mastermind-like transcriptional coactivator 2", "gene_name": "Maml2", "organism": "Rat", "refseq_name": "mastermind-like protein 2 isoform X1", "refseq_ac": [ { "id": "XP_008764219", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_008764219", "type": "external" } ], "gene_names_uniprotkb": "Maml2", "gene_names_refseq": "Maml2", "protein_names_uniprotkb": "Mastermind-like transcriptional coactivator 2", "protein_names_refseq": "mastermind-like protein 2 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:689844); (R-RNO-350054); (R-RNO-8941856)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007221 positive regulation of transcription of Notch receptor target", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1M3B2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08464-1", "uniprot_id": [ { "id": "FZD2_RAT", "url": "https://www.uniprot.org/uniprot/Q08464", "type": "external" } ], "mass": 63885.0, "length": 570, "protein_name": "Frizzled-2", "gene_name": "Fzd2", "organism": "Rat", "refseq_name": "frizzled-2 precursor", "refseq_ac": [ { "id": "NP_742032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_742032", "type": "external" } ], "gene_names_uniprotkb": "Fzd2", "gene_names_refseq": "Fz-10; Fzd10; Fzd2", "protein_names_uniprotkb": "Frizzled-2; Fz-2; rFz2", "protein_names_refseq": "Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 2; frizzled family receptor 2; frizzled-2 precursor; frizzled-2; fz-2; rFz2", "tax_id": 10116, "disease": "omodysplasia 2 (Disease Ontology:DOID:0080845); leiomyoma (Disease Ontology:DOID:127); breast carcinoma (Disease Ontology:DOID:3459); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:64512); (R-RNO-4086398); (R-RNO-4608870); (R-RNO-4641262); (R-RNO-5140745)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10395542;1334084;25120137;27878554", "class_list": "", "function": "A novel pathogenesis of the contribution of downregulation of neurotrophins to the inhibition of the interaction between Wnt5a and Frizzled-2 in astrocytes in minimal hepatic encephalopathy, [RefSeq, PubMed]; H9c2 cell treatment with resveratrol significantly reduces the expression of Frizzled2 and Wnt5a., [RefSeq, PubMed]; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G protein-dependent mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0030165 PDZ domain binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0030855 epithelial cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0071363 cellular response to growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08464-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61810-1", "uniprot_id": [ { "id": "CD5R1_RAT", "url": "https://www.uniprot.org/uniprot/P61810", "type": "external" } ], "mass": 34031.0, "length": 307, "protein_name": "Cyclin-dependent kinase 5 activator 1", "gene_name": "Cdk5r1", "organism": "Rat", "refseq_name": "cyclin-dependent kinase 5 activator 1", "refseq_ac": [ { "id": "NP_446343", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446343", "type": "external" } ], "gene_names_uniprotkb": "Cdk5r1; Cdk5r", "gene_names_refseq": "Cdk5r1; Cdk5r; p35", "protein_names_uniprotkb": "Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; Tau protein kinase II 23 kDa subunit; p23", "protein_names_refseq": "CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 activator 1; p23; tau protein kinase II 23 kDa subunit", "tax_id": 10116, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); trigeminal neuralgia (Disease Ontology:DOID:12098); neurodegenerative disease (Disease Ontology:DOID:1289); hypothyroidism (Disease Ontology:DOID:1459); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (rno:116671); (R-RNO-399956); (R-RNO-6804756)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10903889;15128856;17121855;17143272;18326489;29388152;31314915;33456665;36847717;37848102;8662984", "class_list": "", "function": "CDK5R1 promotes Schwann cell proliferation, migration, and production of neurotrophic factors via CDK5/BDNF/TrkB after sciatic nerve injury., [RefSeq, PubMed]; Involvement of the miR-137-3p/CAPN-2 Interaction in Ischemia-Reperfusion-Induced Neuronal Apoptosis through Modulation of p35 Cleavage and Subsequent Caspase-8 Overactivation. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA HAGLR promotes the proliferation, migration, and neurotrophic factor production of Schwann cells via miR-204/CDK5R1 after sciatic nerve injury., [RefSeq, PubMed]; Luciferase reporter assay, and rescue experiments suggested that miR-sc4 executed its effect through directly targeting cyclin-dependent kinase 5 activator 1 (Cdk5r1), [RefSeq, PubMed]; Spinal crosstalk between Cdk5/p35 and ERK1/2 pathways mediates astrocyte activity via the PPARgamma pathway in a chronic constriction injury model., [RefSeq, PubMed]; p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62938", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0003779 actin binding;GO:0019901 protein kinase binding;GO:0046875 ephrin receptor binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0009792 embryo development ending in birth or egg hatching;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0031175 neuron projection development;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P61810-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08463-1", "uniprot_id": [ { "id": "FZD1_RAT", "url": "https://www.uniprot.org/uniprot/Q08463", "type": "external" } ], "mass": 71027.0, "length": 641, "protein_name": "Frizzled-1", "gene_name": "Fzd1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Fzd1", "gene_names_refseq": "", "protein_names_uniprotkb": "Frizzled-1; Fz-1; rFz1", "protein_names_refseq": "", "tax_id": 10116, "disease": "breast carcinoma (Disease Ontology:DOID:3459)", "pathway": " (rno:58868); (R-RNO-4086400); (R-RNO-4608870); (R-RNO-4641262)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10395542;1334084", "class_list": "", "function": "Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6 or WNT7A. Contradictory results have been reported for activation by WNT7B. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0007267 cell-cell signaling;GO:0010976 positive regulation of neuron projection development;GO:0030855 epithelial cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08463-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R1B1-1", "uniprot_id": [ { "id": "T10B_RAT", "url": "https://www.uniprot.org/uniprot/Q9R1B1", "type": "external" } ], "mass": 11351.0, "length": 100, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim10 B", "gene_name": "Timm10b", "organism": "Rat", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim10 B", "refseq_ac": [ { "id": "NP_445823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445823", "type": "external" } ], "gene_names_uniprotkb": "Timm10b; Fxc1; Tim9b; Timm9b", "gene_names_refseq": "Fxc1; Tim9b; Timm10b; tim10b", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim10 B; Fracture callus protein 1; FxC1; Mitochondrial import inner membrane translocase subunit Tim9 B; TIMM10B; Tim10b", "protein_names_refseq": "fracture callus 1; fracture callus protein 1; fractured callus expressed transcript 1; mitochondrial import inner membrane translocase subunit Tim10 B; mitochondrial import inner membrane translocase subunit Tim9 B; translocase of inner mitochondrial membrane 10 homolog B", "tax_id": 10116, "disease": "", "pathway": " (rno:84384)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10611480;9731230", "class_list": "", "function": "Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O88471", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R1B1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q921A3-1", "uniprot_id": [ { "id": "UBD_RAT", "url": "https://www.uniprot.org/uniprot/Q921A3", "type": "external" } ], "mass": 17983.0, "length": 161, "protein_name": "Ubiquitin D", "gene_name": "AC112568.1; Ubd", "organism": "Rat", "refseq_name": "ubiquitin D", "refseq_ac": [ { "id": "NP_445751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445751", "type": "external" } ], "gene_names_uniprotkb": "AC112568.1; Ubd; AC112568.1; Fat10; Ubd", "gene_names_refseq": "Ubd", "protein_names_uniprotkb": "Ubiquitin D; Diubiquitin; Ubiquitin-like protein FAT10", "protein_names_refseq": "diubiquitin; ubiquitin D; ubiquitin-like protein FAT10", "tax_id": 10116, "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (rno:29168); (R-RNO-8951664)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "15060004;23416168;24452267;29393594;33307094", "class_list": "", "function": "FAT10 protects cardiac myocytes against apoptosis., [RefSeq, PubMed]; These data prove that Ubd is a diabetes susceptibility gene, providing insight into the interplay of multiple genes and environmental factors in T1D susceptibility., [RefSeq, PubMed]; Ubiquitin-like protein FAT10 suppresses SIRT1-mediated autophagy to protect against ischemic myocardial injury., [RefSeq, PubMed]; Ubiquitin-like protein modifier which can be covalently attached to target proteins and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner (By similarity). Conjugation to the target protein is activated by UBA6 via adenylation of its C-terminal glycine (By similarity). Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha (By similarity). Required for TNF-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses (By similarity). Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle (By similarity). May be involved in the formation of aggresomes when proteasome is saturated or impaired (By similarity). Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6MFX3", "ec_number_list": [], "go_molecular_function": "GO:0070628 proteasome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016235 aggresome", "go_biological_process": "GO:0002931 response to ischemia;GO:0034612 response to tumor necrosis factor;GO:0043065 positive regulation of apoptotic process;GO:0001666 response to hypoxia;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q921A3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925B5-1", "uniprot_id": [ { "id": "SYT13_RAT", "url": "https://www.uniprot.org/uniprot/Q925B5", "type": "external" } ], "mass": 46881.0, "length": 426, "protein_name": "Synaptotagmin-13", "gene_name": "Syt13", "organism": "Rat", "refseq_name": "synaptotagmin-13", "refseq_ac": [ { "id": "NP_110466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110466", "type": "external" } ], "gene_names_uniprotkb": "Syt13", "gene_names_refseq": "Syt13; sytXIII", "protein_names_uniprotkb": "Synaptotagmin-13; Synaptotagmin XIII; SytXIII", "protein_names_refseq": "synaptotagmin XIII; synaptotagmin-13", "tax_id": 10116, "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); stomach cancer (Disease Ontology:DOID:10534); breast cancer (Disease Ontology:DOID:1612); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); lung adenocarcinoma (Disease Ontology:DOID:3910); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:80977)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11211934", "class_list": "", "function": "May be involved in transport vesicle docking to the plasma membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERD5", "ec_number_list": [], "go_molecular_function": "GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030133 transport vesicle;GO:0030672 synaptic vesicle membrane;GO:0070382 exocytic vesicle", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:0051726 regulation of cell cycle;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q925B5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0W2-1", "uniprot_id": [ { "id": "S22A2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0W2", "type": "external" } ], "mass": 62343.0, "length": 555, "protein_name": "Solute carrier family 22 member 2", "gene_name": "Slc22a2", "organism": "Rat", "refseq_name": "solute carrier family 22 member 2", "refseq_ac": [ { "id": "NP_113772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113772", "type": "external" } ], "gene_names_uniprotkb": "Slc22a2; Oct2", "gene_names_refseq": "OCT2r; OCT2; Slc22a2; rOCT2", "protein_names_uniprotkb": "Solute carrier family 22 member 2; Organic cation transporter 2; rOCT2", "protein_names_refseq": "organic cation transporter 2; solute carrier family 22 (organic cation transporter), member 2; solute carrier family 22 member 2", "tax_id": 10116, "disease": "kidney failure (Disease Ontology:DOID:1074); extrahepatic cholestasis (Disease Ontology:DOID:13619); intrahepatic cholestasis (Disease Ontology:DOID:1852); hyperuricemia (Disease Ontology:DOID:1920); acute kidney failure (Disease Ontology:DOID:3021); end stage renal disease (Disease Ontology:DOID:783)", "pathway": " (rno:29503); (R-RNO-112311); (R-RNO-181430); (R-RNO-2161517); (R-RNO-442660); (R-RNO-549127)", "pathway_count": 6, "publication_count": 23, "publication_id_list": "10385678;10812069;10889205;11083459;11758759;12538837;15817714;16006492;16242669;16272756;16581093;17567940;17582384;18180268;27901065;28414026;30120945;30951542;32484793;8702418;9260930;9812985;9830022", "class_list": "", "function": "Although multiple factors may influence renal handling of drugs, these observations can be accounted for, at least in part, by downregulation of Mate1-mediated apical efflux from tubular cells and Oct2-mediated basolateral uptake. Our results suggest that hyperuricemia could alter the disposition of drugs that are substrates of Mate1 and/or Oct2. Publication Status: Online-Only, [RefSeq, PubMed]; Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10889205, PubMed:12538837, PubMed:15817714, PubMed:16581093, PubMed:9812985). Functions as a Na(+)-independent, bidirectional uniporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10889205). However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (PubMed:10889205). Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (By similarity). Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters (PubMed:16581093, PubMed:9812985). Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system (By similarity). Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium (PubMed:15817714). Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN) (PubMed:11758759). Mediates the uptake and efflux of choline (PubMed:10889205). Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamine putrescine (PubMed:12538837). Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (By similarity). Also involved in the uptake of xenobiotic 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Findings indicate that OCT2 knockout possibly mitigate OTA-induced apoptosis by preventing the increase of Caspase 3 and CDK1, [RefSeq, PubMed]; Formononetin prevents cisplatin-induced acute kidney injury by targeting Oct2/TP53 in the kidney. Erratum:[Toxicol Appl Pharmacol. 2022 Sep 1;450:116133. doi: 10.1016/j.taap.2022.116133. PMID: 35716766], [RefSeq, PubMed]; Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice., [RefSeq, PubMed]; These results provide the first identification of a high affinity neuronal transporter for p-tyramine, and also confirm the recently described localization of OCT2 in pre-synaptic terminals. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P70485;P97558", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0015697 quaternary ammonium group transport;GO:0015870 acetylcholine transport;GO:0015695 organic cation transport;GO:0055085 transmembrane transport;GO:0006812 monoatomic cation transport", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9R0W2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z118-1", "uniprot_id": [ { "id": "PTBP3_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z118", "type": "external" } ], "mass": 56716.0, "length": 523, "protein_name": "Polypyrimidine tract-binding protein 3", "gene_name": "Ptbp3", "organism": "Rat", "refseq_name": "polypyrimidine tract-binding protein 3", "refseq_ac": [ { "id": "NP_112636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112636", "type": "external" } ], "gene_names_uniprotkb": "Ptbp3; Rod1", "gene_names_refseq": "Ptbp3; Rod1", "protein_names_uniprotkb": "Polypyrimidine tract-binding protein 3; Regulator of differentiation 1; Rod1", "protein_names_refseq": "ROD1 regulator of differentiation 1; polypyrimidine tract-binding protein 3; regulator of differentiation (in S. pombe) 1; regulator of differentiation 1", "tax_id": 10116, "disease": "", "pathway": " (rno:83515)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10207106", "class_list": "", "function": "RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes Fas exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z118-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKL9-1", "uniprot_id": [ { "id": "PR2B1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKL9", "type": "external" } ], "mass": 26060.0, "length": 228, "protein_name": "Prolactin-2B1", "gene_name": "Prl2b1", "organism": "Rat", "refseq_name": "prolactin-2B1 precursor", "refseq_ac": [ { "id": "NP_620216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620216", "type": "external" } ], "gene_names_uniprotkb": "Prl2b1; Prlpk", "gene_names_refseq": "Ghd11; Prl2b1; Prlpk", "protein_names_uniprotkb": "Prolactin-2B1; PLP-K; PRL-like protein K; Placental prolactin-like protein K", "protein_names_refseq": "PLP-K; PRL-like protein K; growth hormone d11; placental prolactin-like protein K; prolactin-2B1 precursor; prolactin-2B1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); impulse control disorder (Disease Ontology:DOID:10937); depressive disorder (Disease Ontology:DOID:1596); severe acute respiratory syndrome (Disease Ontology:DOID:2945); carotid artery disease (Disease Ontology:DOID:3407); prolactinoma (Disease Ontology:DOID:5394); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:192224)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10471365;10856884", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0R8", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JKL9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2X3-1", "uniprot_id": [ { "id": "PSD10_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2X3", "type": "external" } ], "mass": 24985.0, "length": 231, "protein_name": "26S proteasome non-ATPase regulatory subunit 10", "gene_name": "Psmd10", "organism": "Rat", "refseq_name": "26S proteasome non-ATPase regulatory subunit 10 isoform 1", "refseq_ac": [ { "id": "NP_446377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446377", "type": "external" } ], "gene_names_uniprotkb": "Psmd10; AABR07040855.1", "gene_names_refseq": "Psmd10; p28Gank", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; Gankyrin", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 10 isoform 1; 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; gankyrin; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10", "tax_id": 10116, "disease": "", "pathway": " (rno:116722); (R-RNO-9907900)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module (By similarity). Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0008540 proteasome regulatory particle, base subcomplex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030307 positive regulation of cell growth;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9Z2X3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2I7-1", "uniprot_id": [ { "id": "SVOP_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2I7", "type": "external" } ], "mass": 60804.0, "length": 548, "protein_name": "Synaptic vesicle 2-related protein", "gene_name": "Svop", "organism": "Rat", "refseq_name": "synaptic vesicle 2-related protein", "refseq_ac": [ { "id": "NP_599231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599231", "type": "external" } ], "gene_names_uniprotkb": "Svop", "gene_names_refseq": "Svop", "protein_names_uniprotkb": "Synaptic vesicle 2-related protein; SV2-related protein", "protein_names_refseq": "synaptic vesicle 2-related protein-like; synaptic vesicle 2-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:171442)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22673903;9801366", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z2I7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLS3-1", "uniprot_id": [ { "id": "TAOK2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLS3", "type": "external" } ], "mass": 138751.0, "length": 1235, "protein_name": "Serine/threonine-protein kinase TAO2", "gene_name": "Taok2", "organism": "Rat", "refseq_name": "serine/threonine-protein kinase TAO2", "refseq_ac": [ { "id": "NP_073193", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073193", "type": "external" } ], "gene_names_uniprotkb": "Taok2; Tao2", "gene_names_refseq": "Tao2; Taok2", "protein_names_uniprotkb": "Serine/threonine-protein kinase TAO2; 2.7.11.1; Thousand and one amino acid protein 2", "protein_names_refseq": "serine-threonine kinase; serine/threonine-protein kinase TAO2; thousand and one amino acid protein 2", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cancer (Disease Ontology:DOID:162); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (rno:64666)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10497253;15458637;16761096;17988630;28065648;38843836", "class_list": "", "function": "Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation., [UniProtKB, PubMed, PubMed]; TAOK2 directly phosphorylates the cytoskeletal GTPase Septin7, at an evolutionary conserved residue. This phosphorylation induces translocation of Septin7 to the spine, where it associates with and stabilizes the scaffolding protein PSD95, promoting dendritic spine maturation., [RefSeq, PubMed]; This analysis of atomic details for TAO2-staurosporine interactions explains the relatively low potency of staurosporine against TAO2, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6BM05", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.4.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.18", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0038191 neuropilin binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007409 axonogenesis;GO:0032956 regulation of actin cytoskeleton organization;GO:0043410 positive regulation of MAPK cascade;GO:0046330 positive regulation of JNK cascade;GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9JLS3-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0T0-1", "uniprot_id": [ { "id": "TPMT_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0T0", "type": "external" } ], "mass": 27692.0, "length": 240, "protein_name": "Thiopurine S-methyltransferase", "gene_name": "Tpmt", "organism": "Rat", "refseq_name": "thiopurine S-methyltransferase", "refseq_ac": [ { "id": "NP_001382599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382599", "type": "external" } ], "gene_names_uniprotkb": "Tpmt", "gene_names_refseq": "Tpmt", "protein_names_uniprotkb": "Thiopurine S-methyltransferase; 2.1.1.67; Thiopurine methyltransferase", "protein_names_refseq": "thiopurine S-methyltransferase; thiopurine methyltransferase", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); poor metabolism of thiopurines 1 (Disease Ontology:DOID:0061004); poor metabolism of thiopurines (Disease Ontology:DOID:0080172); leukopenia (Disease Ontology:DOID:615); alopecia (Disease Ontology:DOID:987); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (rno:690050); (R-RNO-156581); (R-RNO-9748787)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.67", "type": "external" } ], "go_molecular_function": "GO:0008119 thiopurine S-methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0032259 methylation;GO:0033574 response to testosterone", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9Z0T0-1", "record_type": "protein", "filter_code": "0000000.0000011.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTN5-1", "uniprot_id": [ { "id": "TPC1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTN5", "type": "external" } ], "mass": 94405.0, "length": 817, "protein_name": "Two pore calcium channel protein 1", "gene_name": "Tpcn1", "organism": "Rat", "refseq_name": "two pore calcium channel protein 1", "refseq_ac": [ { "id": "NP_647548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647548", "type": "external" } ], "gene_names_uniprotkb": "Tpcn1; Tpc1", "gene_names_refseq": "Tpcn1", "protein_names_uniprotkb": "Two pore calcium channel protein 1; Voltage-dependent calcium channel protein TPC1", "protein_names_refseq": "two pore calcium channel protein 1; two pore channel 1; voltage-dependent calcium channel protein TPC1; voltage-gated Ca channel", "tax_id": 10116, "disease": "", "pathway": " (rno:246215); (R-RNO-2672351)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10753632;16627563;31557916;34263977", "class_list": "", "function": "Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles. Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis. Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2. Required for mTOR-dependent nutrient sensing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NAADP-induced intracellular calcium ion is mediated by the TPCs (two-pore channels) in hypoxia-induced pulmonary arterial hypertension., [RefSeq, PubMed]; Rat GnRH neurones express all five subtypes of voltage-gated Ca(2+) channels and exhibit an apamin-sensitive I(sAHP), which may allow continuous firing in response to a relatively strong depolarizing input., [RefSeq, PubMed]; TPC1 is involved in the norepinephrine (NE)-stimulated [Ca(2+)]i rise in Smooth muscle cells. Inhibition of TPC1 activity by NED 19 could be the reason for partial inhibition of aortic rings contraction in response to NE. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6P6R1", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0072345 NAADP-sensitive calcium-release channel activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0019905 syntaxin binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0010508 positive regulation of autophagy;GO:0035725 sodium ion transmembrane transport;GO:0075509 endocytosis involved in viral entry into host cell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WTN5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKB8-1", "uniprot_id": [ { "id": "PRP18_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKB8", "type": "external" } ], "mass": 39866.0, "length": 342, "protein_name": "Pre-mRNA-splicing factor 18", "gene_name": "Prpf18", "organism": "Rat", "refseq_name": "pre-mRNA-splicing factor 18", "refseq_ac": [ { "id": "NP_612532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612532", "type": "external" } ], "gene_names_uniprotkb": "Prpf18; Kcrf; Prp18", "gene_names_refseq": "KCRF; Pprf18; Prpf18", "protein_names_uniprotkb": "Pre-mRNA-splicing factor 18; PRP18 homolog; Potassium channel regulatory factor", "protein_names_refseq": "PRP18 homolog; PRP18 pre-mRNA processing factor 18 homolog; potassium channel regulatory factor; pre-mRNA-splicing factor 18", "tax_id": 10116, "disease": "", "pathway": " (rno:171552); (R-RNO-72163)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10924366", "class_list": "", "function": "Participates in the second step of pre-mRNA splicing (By similarity). Down-regulates the expression of potassium channel subunits., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005682 U5 snRNP;GO:0046540 U4/U6 x U5 tri-snRNP complex;GO:0071021 U2-type post-spliceosomal complex;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000350 generation of catalytic spliceosome for second transesterification step;GO:0051248 negative regulation of protein metabolic process;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JKB8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPJ0-1", "uniprot_id": [ { "id": "NUCKS_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPJ0", "type": "external" } ], "mass": 27140.0, "length": 243, "protein_name": "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1", "gene_name": "LOC120093168; Nucks1", "organism": "Rat", "refseq_name": "nuclear ubiquitous casein and cyclin-dependent kinase substrate 1", "refseq_ac": [ { "id": "NP_073636", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073636", "type": "external" } ], "gene_names_uniprotkb": "LOC120093168; Nucks1; LOC120093168; Nucks", "gene_names_refseq": "Nucks1; Nucks", "protein_names_uniprotkb": "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1", "protein_names_refseq": "nuclear ubiquitous casein and cyclin-dependent kinase substrate 1; nuclear ubiquitous casein and cyclin-dependent kinases substrate-like; nuclear ubiquitous casein and cyclin-dependent kinases substrate; nuclear ubiquitous casein kinase 2; nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate", "tax_id": 10116, "disease": "", "pathway": " (rno:120093168); (rno:64709)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11298763;11827176;16641100;22673903;24140890", "class_list": "", "function": "Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR). Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1., [UniProtKB, UniProtKB]; Consequences of CK2 signaling to the nuclear matrix., [RefSeq, PubMed]; Results show that Nucks expression increased during the initial stages of embryonic development, and then gradually decreased until birth in all tissues except the nervous tissue and muscle fibers. GeneRIF: The expression of Nucks in both proliferating and quiescent cells and its correlation with Bax levels and apoptosis strongly suggest that Nucks plays complex roles in cell homeostasis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 23, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042593 glucose homeostasis;GO:0001678 intracellular glucose homeostasis;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9EPJ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQ10-1", "uniprot_id": [ { "id": "PARI_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQ10", "type": "external" } ], "mass": 63902.0, "length": 573, "protein_name": "PCNA-interacting partner", "gene_name": "Parpbp", "organism": "Rat", "refseq_name": "PCNA-interacting partner isoform 3", "refseq_ac": [ { "id": "NP_001160148", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160148", "type": "external" } ], "gene_names_uniprotkb": "Parpbp; Arom; Pari", "gene_names_refseq": "AROM; PARI; Parpbp", "protein_names_uniprotkb": "PCNA-interacting partner; AROM; Antisense RNA overlapping MCH gene protein; PARI; PARP-1 binding protein; PARP1-binding protein; PARPBP", "protein_names_refseq": "PARP-1 binding protein; PCNA-interacting partner isoform 3; PCNA-interacting partner; antisense RNA overlapping MCH gene protein", "tax_id": 10116, "disease": "", "pathway": " (rno:100310874)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11006283", "class_list": "", "function": "Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity). Binds single-strand DNA and poly(A) homopolymers., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0005634 nucleus", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EQ10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVB1-1", "uniprot_id": [ { "id": "RAB6A_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVB1", "type": "external" } ], "mass": 23590.0, "length": 208, "protein_name": "Ras-related protein Rab-6A", "gene_name": "Rab6a", "organism": "Rat", "refseq_name": "ras-related protein Rab-6A isoform 1", "refseq_ac": [ { "id": "NP_001401384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001401384", "type": "external" } ], "gene_names_uniprotkb": "Rab6a; Rab6", "gene_names_refseq": "RCO4-3; Rab6a; Rab6b; Rab6", "protein_names_uniprotkb": "Ras-related protein Rab-6A; 3.6.5.2; Rab-6", "protein_names_refseq": "RAB6, member RAS oncogene family; RAB6B, member RAS oncogene family; rab-6; ras-related protein Rab-6A isoform 1; ras-related protein Rab-6A", "tax_id": 10116, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:84379); (R-RNO-6798695); (R-RNO-6811436); (R-RNO-6811440); (R-RNO-8854214); (R-RNO-8873719); (R-RNO-8876198)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "11062069;22673903;33571451", "class_list": "", "function": "Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers. Erratum:[Dev Cell. 2021 May 17;56(10):1552-1554. doi: 10.1016/j.devcel.2021.04.028. PMID: 34004153], [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Recruits VPS13B to the Golgi membrane. Plays a role in neuron projection development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0051117 ATPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0070381 endosome to plasma membrane transport vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0042147 retrograde transport, endosome to Golgi;GO:0034067 protein localization to Golgi apparatus;GO:1903292 protein localization to Golgi membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9WVB1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV25-1", "uniprot_id": [ { "id": "PUF60_RAT", "url": "https://www.uniprot.org/uniprot/Q9WV25", "type": "external" } ], "mass": 60249.0, "length": 564, "protein_name": "Poly(U)-binding-splicing factor PUF60", "gene_name": "Puf60", "organism": "Rat", "refseq_name": "poly(U)-binding-splicing factor PUF60 isoform 1", "refseq_ac": [ { "id": "NP_001386320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001386320", "type": "external" } ], "gene_names_uniprotkb": "Puf60; Siahbp1", "gene_names_refseq": "Puf60; Siahbp1", "protein_names_uniprotkb": "Poly(U)-binding-splicing factor PUF60; 60 kDa poly(U)-binding-splicing factor; RNA-binding protein Siah-BP; Siah-binding protein 1", "protein_names_refseq": "60 kDa poly(U)-binding-splicing factor; FBP interacting repressor; RNA-binding protein Siah-BP; Ro ribonucleoprotein-binding protein 1; poly(U)-binding-splicing factor PUF60 isoform 1; poly(U)-binding-splicing factor PUF60; poly-U binding splicing factor 60K; pyrimidine tract binding splicing factor; siah binding protein 1; siah-binding protein 1", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-72163); (R-RNO-9770562); (R-RNO-9943411)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "29393594;34502162", "class_list": "", "function": "DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0006376 mRNA splice site recognition;GO:0000380 alternative mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9WV25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV59-1", "uniprot_id": [ { "id": "TRI17_RAT", "url": "https://www.uniprot.org/uniprot/Q9WV59", "type": "external" } ], "mass": 54954.0, "length": 477, "protein_name": "E3 ubiquitin-protein ligase TRIM17", "gene_name": "Trim17", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM17", "refseq_ac": [ { "id": "NP_073635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073635", "type": "external" } ], "gene_names_uniprotkb": "Trim17; Terf", "gene_names_refseq": "Rnf16; Trim17", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM17; 2.3.2.27; RING-type E3 ubiquitin transferase TRIM17; Testis RING finger protein; Tripartite motif-containing protein 17", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM17; RING finger protein terf; RING-type E3 ubiquitin transferase TRIM17; ring finger protein 16; testis RING finger protein; tripartite motif protein 17; tripartite motif-containing protein 17", "tax_id": 10116, "disease": "", "pathway": " (rno:64702)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9792805", "class_list": "", "function": "E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation. Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation. Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (By similarity). Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (By similarity). Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005764 lysosome", "go_biological_process": "GO:0045087 innate immune response;GO:0032880 regulation of protein localization;GO:0006914 autophagy;GO:0010468 regulation of gene expression;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WV59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R283-1", "uniprot_id": [ { "id": "TRPC2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R283", "type": "external" } ], "mass": 130467.0, "length": 1170, "protein_name": "Short transient receptor potential channel 2", "gene_name": "Trpc2; Xndc1", "organism": "Rat", "refseq_name": "short transient receptor potential channel 2", "refseq_ac": [ { "id": "NP_072160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072160", "type": "external" } ], "gene_names_uniprotkb": "Trpc2; Xndc1; Trp2; Trpc2", "gene_names_refseq": "Trpc2; Trrp2", "protein_names_uniprotkb": "Short transient receptor potential channel 2; TRP-2; Transient receptor protein 2; TrpC2; rTrp2", "protein_names_refseq": "TRP-2; rTrp2; short transient receptor potential channel 2; transient receptor potential cation channel, subfamily C, member 2, pseudogene; transient receptor protein 2", "tax_id": 10116, "disease": "", "pathway": " (rno:102549471); (rno:64573)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10318963;23018590;23144458;23578584", "class_list": "", "function": "Ca(2+) entry via TRPC2 contributes to CaCC activation., [RefSeq, PubMed]; TRPC2 is an important regulator of rat thyroid cell function., [RefSeq, PubMed]; TRPC2, by regulating STIM2, PKC expression, and SERCA activity, regulates calcium homeostasis in thyroid cells., [RefSeq, PubMed]; Thought to form a receptor-activated calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein coupled receptors. Is not activated by intracellular calcium store depletion., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B5DFD7;O70485", "ec_number_list": [], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005516 calmodulin binding;GO:0003684 damaged DNA binding;GO:0019992 diacylglycerol binding;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0000139 Golgi membrane;GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0005886 plasma membrane", "go_biological_process": "GO:0002121 inter-male aggressive behavior;GO:0002124 territorial aggressive behavior;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9R283-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPC6-1", "uniprot_id": [ { "id": "PROF2_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPC6", "type": "external" } ], "mass": 15002.0, "length": 140, "protein_name": "Profilin-2", "gene_name": "Pfn2", "organism": "Rat", "refseq_name": "profilin-2", "refseq_ac": [ { "id": "NP_110500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110500", "type": "external" } ], "gene_names_uniprotkb": "Pfn2", "gene_names_refseq": "Pfn2", "protein_names_uniprotkb": "Profilin-2; Profilin II", "protein_names_refseq": "profilin II; profilin-2-like; profilin-2", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:81531); (R-RNO-5663220)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11027290;14517206;15477377;19307711", "class_list": "", "function": "Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG., [UniProtKB, UniProtKB, UniProtKB]; Following hypophysectomy, the actin cytoskeleton of the Sertoli cell shifts to a predominantly depolymerized state, perhaps in part because of decreases in profilin II and espin gene products., [RefSeq, PubMed]; RhoA/ROCK/PIIa-mediated regulation of actin stability, shown to be essential for neuritogenesis, may constitute a central mechanism throughout neuronal differentiation., [RefSeq, PubMed]; The binding site for proline-rich peptides is pre-organized. The C-terminus 2a is well ordered in the absence of ligand peptide. Pfn2 binds to the neuronal protein palladin., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9JHU7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0043195 terminal bouton;GO:0098794 postsynapse", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0098885 modification of postsynaptic actin cytoskeleton;GO:1900028 negative regulation of ruffle assembly;GO:0032233 positive regulation of actin filament bundle assembly;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9EPC6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLT7-1", "uniprot_id": [ { "id": "RX_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLT7", "type": "external" } ], "mass": 36337.0, "length": 342, "protein_name": "Retinal homeobox protein Rx", "gene_name": "Rax", "organism": "Rat", "refseq_name": "retinal homeobox protein Rx", "refseq_ac": [ { "id": "NP_446130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446130", "type": "external" } ], "gene_names_uniprotkb": "Rax; Rx", "gene_names_refseq": "Rax; Rx", "protein_names_uniprotkb": "Retinal homeobox protein Rx; Retina and anterior neural fold homeobox protein", "protein_names_refseq": "retina and anterior neural fold homeobox protein; retinal homeobox protein Rx; retinal homeobox transcription factor Rx/rax", "tax_id": 10116, "disease": "syndromic microphthalmia 16 (Disease Ontology:DOID:0060842)", "pathway": " (rno:114213)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "21749377;21897745", "class_list": "", "function": "Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; RAX expression in the retina of diabetic rats may be indirectly regulated by miR-29b., [RefSeq, PubMed]; These findings are consistent with the evidence that Rax is of functional importance in eye development and suggest a role of Rax in the developing pineal gland, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q99PA4", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0060173 limb development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JLT7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKU1-1", "uniprot_id": [ { "id": "TR119_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKU1", "type": "external" } ], "mass": 37852.0, "length": 335, "protein_name": "Taste receptor type 2 member 119", "gene_name": "Tas2r119", "organism": "Rat", "refseq_name": "taste receptor type 2 member 119", "refseq_ac": [ { "id": "NP_076483", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076483", "type": "external" } ], "gene_names_uniprotkb": "Tas2r119; Tas2r19; Tas2r1", "gene_names_refseq": "T2R1; Tas2r119; Tas2r1", "protein_names_uniprotkb": "Taste receptor type 2 member 119; T2R119; T2R19; T2R1; Taste receptor type 2 member 19; Taste receptor type 2 member 1", "protein_names_refseq": "T2R119; T2R19; taste receptor type 2 member 119; taste receptor type 2 member 19; taste receptor type 2 member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:78979); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10761934;10761935;11696554;11854532;12139982;12581520;22836012", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5., [UniProtKB]; T2R1, a receptor for bitter taste, is expressed in brainstem., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JKU1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZA1-1", "uniprot_id": [ { "id": "PHLA1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZA1", "type": "external" } ], "mass": 45746.0, "length": 407, "protein_name": "Pleckstrin homology-like domain family A member 1", "gene_name": "Phlda1", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Phlda1; Pqr", "gene_names_refseq": "", "protein_names_uniprotkb": "Pleckstrin homology-like domain family A member 1; PQ-rich protein; PQR protein; Proline- and glutamine-rich protein", "protein_names_refseq": "", "tax_id": 10116, "disease": "retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (rno:29380); (R-RNO-8854521)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10428057", "class_list": "", "function": "Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0031410 cytoplasmic vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0021879 forebrain neuron differentiation;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0009101 glycoprotein biosynthetic process;GO:1904044 response to aldosterone", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9QZA1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZP2-1", "uniprot_id": [ { "id": "PRDM4_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZP2", "type": "external" } ], "mass": 87392.0, "length": 798, "protein_name": "PR domain zinc finger protein 4", "gene_name": "Prdm4", "organism": "Rat", "refseq_name": "PR domain zinc finger protein 4 isoform 1", "refseq_ac": [ { "id": "NP_579846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579846", "type": "external" } ], "gene_names_uniprotkb": "Prdm4", "gene_names_refseq": "Prdm4; SC-1", "protein_names_uniprotkb": "PR domain zinc finger protein 4; 2.1.1.-; PR domain-containing protein 4", "protein_names_refseq": "PR domain 4; PR domain containing 4; PR domain zinc finger protein 4 isoform 1; PR domain zinc finger protein 4; PR domain-containing protein 4", "tax_id": 10116, "disease": "", "pathway": " (rno:170820)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10485890;23048031;27125459", "class_list": "", "function": "May function as a transcription factor involved in cell differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SC1 and PRMT5 are components of an epigenetic regulatory complex that maintains the 'stem-like' cellular state of the neural stem cells., [RefSeq, PubMed]; We investigated the potential mechanism of nuclear shuttling of PRDM4 via the importin alpha/beta-mediated pathway and find that PRDM4 nuclear targeting is independent of alpha/beta-mediated nuclear import., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0008168 methyltransferase activity;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0010629 negative regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071363 cellular response to growth factor stimulus;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QZP2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920E1-1", "uniprot_id": [ { "id": "PAR3_RAT", "url": "https://www.uniprot.org/uniprot/Q920E1", "type": "external" } ], "mass": 41796.0, "length": 368, "protein_name": "Proteinase-activated receptor 3", "gene_name": "F2rl2", "organism": "Rat", "refseq_name": "proteinase-activated receptor 3 precursor", "refseq_ac": [ { "id": "NP_445765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445765", "type": "external" } ], "gene_names_uniprotkb": "F2rl2; Par3", "gene_names_refseq": "F2rl2; PAR3", "protein_names_uniprotkb": "Proteinase-activated receptor 3; Coagulation factor II receptor-like 2; PAR-3; Thrombin receptor-like 2", "protein_names_refseq": "G-protein coupled receptor; PAR-3; coagulation factor II receptor-like 2; protease-activated receptor 3; proteinase-activated receptor 3 precursor; proteinase-activated receptor 3; thrombin receptor-like 2", "tax_id": 10116, "disease": "", "pathway": " (rno:29636); (R-RNO-375276); (R-RNO-416476); (R-RNO-456926)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "12165407;12836167;14705148;16403464;17136598", "class_list": "", "function": "Expression of protease-activated receptor 3 does not change significantly in the hippocampus following severe ischemic insult., [RefSeq, PubMed]; Involvement of the thrombin receptors PAR-1, PAR-3, and PAR-4 in the pathophysiology of brain ischemia was suggested by decreased mRNA levels observed for PAR-1, -2, and -3, whereas PAR-4 levels were reduced only after 7 days, [RefSeq, PubMed]; PAR 3 is regulated at the transcriptional level in a rat model of lipopolysaccharide induced acute lung injury and probably has a distinct role., [RefSeq, PubMed]; PAR1 and PAR3 could be involved in thrombin-modulated initiation of post-ischemic inflammation and PAR4 may be associated with neuronal degeneration. (Protease-activated receptor 1, 3, 4), [RefSeq, PubMed]; Par-3 mRNA is expressed in the developing rat eye and adult retina but shows a delayed upregulation after optic nerve crush compared to Par-1, Par-2, and Par-4., [RefSeq, PubMed]; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015057 thrombin-activated receptor activity;GO:0004930 G protein-coupled receptor activity;GO:0048018 receptor ligand activity;GO:0001648 proteinase-activated receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0003093 regulation of glomerular filtration;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q920E1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q925B4-1", "uniprot_id": [ { "id": "SYT8_RAT", "url": "https://www.uniprot.org/uniprot/Q925B4", "type": "external" } ], "mass": 43980.0, "length": 395, "protein_name": "Synaptotagmin-8", "gene_name": "Syt8", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Syt8", "gene_names_refseq": "", "protein_names_uniprotkb": "Synaptotagmin-8; Synaptotagmin VIII; SytVIII", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:60566); (R-RNO-8856825); (R-RNO-8856828)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11309201;7791877;9689015", "class_list": "", "function": "Involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62749;Q925B9", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0030276 clathrin binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0001669 acrosomal vesicle;GO:0031982 vesicle", "go_biological_process": "GO:0007340 acrosome reaction;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q925B4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0J5-1", "uniprot_id": [ { "id": "TRXR2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0J5", "type": "external" } ], "mass": 56575.0, "length": 526, "protein_name": "Thioredoxin reductase 2, mitochondrial", "gene_name": "Txnrd2", "organism": "Rat", "refseq_name": "thioredoxin reductase 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_072106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_072106", "type": "external" } ], "gene_names_uniprotkb": "Txnrd2; Trxr2", "gene_names_refseq": "Tr3; Trxr2; Trxrd2; Txnrd2", "protein_names_uniprotkb": "Thioredoxin reductase 2, mitochondrial; 1.8.1.9; Thioredoxin reductase TR3", "protein_names_refseq": "thioredoxin reductase 2, mitochondrial precursor; thioredoxin reductase 2, mitochondrial; thioredoxin reductase TR3", "tax_id": 10116, "disease": "chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); familial glucocorticoid deficiency (Disease Ontology:DOID:0080620)", "pathway": " (rno:50551); (R-RNO-3299685)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11060283;23613536;25055978;26674287;38513765;9988709", "class_list": "", "function": "Active TrxR1 and TrxR2 are required for cerebellar granule cell survival., [RefSeq, PubMed]; Different doxorubicin formulations decreased liver expression of TXNRD2., [RefSeq, PubMed]; Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains mitochondrial thioredoxin in a reduced state. May play a role in redox-regulated cell signaling., [UniProtKB, UniProtKB, PubMed]; The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2017]., [RefSeq]; Txnrd2 Attenuates Early Brain Injury by Inhibition of Oxidative Stress and Endoplasmic Reticulum Stress via Trx2/Prx3 Pathway after Intracerebral Hemorrhage in Rats., [RefSeq, PubMed]; Upregulation of thioredoxin reductase-2 plays a critical role in preserving the mitochondrial redox status in the heart and skeletal muscle with exercise., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" }, { "id": "1.11.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.2", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0007507 heart development;GO:0042542 response to hydrogen peroxide;GO:0030097 hemopoiesis;GO:0010269 response to selenium ion;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z0J5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES87-1", "uniprot_id": [ { "id": "PRSS8_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES87", "type": "external" } ], "mass": 36857.0, "length": 342, "protein_name": "Prostasin", "gene_name": "Prss8", "organism": "Rat", "refseq_name": "prostasin precursor", "refseq_ac": [ { "id": "NP_620191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620191", "type": "external" } ], "gene_names_uniprotkb": "Prss8", "gene_names_refseq": "CAP1; Prss8", "protein_names_uniprotkb": "Prostasin; 3.4.21.-; CAP1; Channel-activating protease 1; Serine protease 8", "protein_names_refseq": "channel-activating protease 1; prostasin precursor; prostasin; protease, serine, 8", "tax_id": 10116, "disease": "autosomal recessive congenital ichthyosis 4B (Disease Ontology:DOID:0060713); ovarian cancer (Disease Ontology:DOID:2394); breast carcinoma (Disease Ontology:DOID:3459); prostate carcinoma in situ (Disease Ontology:DOID:8634); alopecia (Disease Ontology:DOID:987)", "pathway": " (rno:192107)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11373334;20201958;20645929;22705055", "class_list": "", "function": "A 12-bp deletion in the third exon of the Prss8 gene is responsible for the mutant 'hairless', frizzy-Charles River (frCR) phenotype. No alterations to Prss8 coding sequences were detected in the allelic 'fuzzy' rat variant., [RefSeq, PubMed]; Data show that apical, GPI-anchored, lipid raft-associated serine protease activity, compatible with prostasin, is necessary for the development of a high-resistance collecting duct epithelium., [RefSeq, PubMed]; Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity., [RefSeq, PubMed]; Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G) (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6GSY8;Q9ER01", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017080 sodium channel regulator activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0016485 protein processing;GO:0051385 response to mineralocorticoid;GO:0043434 response to peptide hormone;GO:0009410 response to xenobiotic stimulus;GO:0010765 positive regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9ES87-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZT3-1", "uniprot_id": [ { "id": "PA2GX_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZT3", "type": "external" } ], "mass": 17088.0, "length": 151, "protein_name": "Group 10 secretory phospholipase A2", "gene_name": "Pla2g10", "organism": "Rat", "refseq_name": "group 10 secretory phospholipase A2 precursor", "refseq_ac": [ { "id": "NP_058872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058872", "type": "external" } ], "gene_names_uniprotkb": "Pla2g10", "gene_names_refseq": "PLA2GX; Pla2g10; sPLA2-X", "protein_names_uniprotkb": "Group 10 secretory phospholipase A2; 3.1.1.4; GX sPLA2; Group X secretory phospholipase A2; Phosphatidylcholine 2-acylhydrolase 10; sPLA2-X", "protein_names_refseq": "GX sPLA2; group 10 secretory phospholipase A2 precursor; group 10 secretory phospholipase A2; group X phospholipase A2; group X secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 10; phosphatidylcholine 2-acylhydrolase GX; phospholipase A2, group 10", "tax_id": 10116, "disease": "", "pathway": " (rno:29359); (R-RNO-1482788); (R-RNO-1482801); (R-RNO-1482839); (R-RNO-1482922); (R-RNO-1482925); (R-RNO-1483166)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "10531313;15781456", "class_list": "", "function": "Group X secreted phospholipase A2 is expressed in neural cells and has neuritogenic action, [RefSeq, PubMed]; Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells. Efficiently hydrolyzes and inactivates platelet activating factor (PAF), a potent lipid mediator present in oxidized LDL (By similarity). May act in an autocrine and paracrine manner. Secreted by lung epithelium, targets membrane phospholipids of infiltrating eosinophils, releasing arachidonate and boosting eicosanoid and cysteinyl leukotriene synthesis involved in airway inflammatory response. Secreted by gut epithelium, hydrolyzes dietary and biliary phosphatidylcholines in the gastrointestinal lumen. Plays a stem cell regulator role in colon epithelium. Within intracellular compartment, mediates Paneth-like cell differentiation and its stem cell supporting functions by inhibiting the Wnt signaling pathway in intestinal stem cell (ISC). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ISCs and tissue regeneration. May participate in hair follicle morphogenesis by regulating phosphatidylethanolamines metabolism at the outermost epithelial layer and facilitating melanin synthesis. By releasing lysophosphatidylcholines (LPCs) at sperm acrosome, controls sperm cell capacitation, acrosome reaction and overall fertility. May promote neurite outgrowth in neuron fibers involved in nociception (By similarity). Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of phosphatidylglycerols and phosphatidylethanolamines, which are major components of membrane phospholipids in bacteria. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. In pulmonary epithelium, may contribute to host defense response against adenoviral infection. Prevents adenovirus entry into host cells by hydrolyzing host cell plasma membrane, releasing C16:0 LPCs that inhibit virus-mediated membrane fusion and viral infection. Likely prevents adenoviral entry into the endosomes of host cells (By similarity). May play a role in maturation and activation of innate immune cells including macrophages, group 2 innate lymphoid cells and mast cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0004620 phospholipase activity;GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005764 lysosome;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0046473 phosphatidic acid metabolic process;GO:0034638 phosphatidylcholine catabolic process;GO:0051977 lysophospholipid transport;GO:0043249 erythrocyte maturation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9QZT3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKT9-1", "uniprot_id": [ { "id": "TR107_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKT9", "type": "external" } ], "mass": 35052.0, "length": 308, "protein_name": "Taste receptor type 2 member 107", "gene_name": "Tas2r107", "organism": "Rat", "refseq_name": "taste receptor type 2 member 107", "refseq_ac": [ { "id": "NP_076485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076485", "type": "external" } ], "gene_names_uniprotkb": "Tas2r107; Tas2r10; Tas2r4", "gene_names_refseq": "T2R4; Tas2r107; Tas2r10", "protein_names_uniprotkb": "Taste receptor type 2 member 107; T2R107; T2R4; Taste receptor type 2 member 4", "protein_names_refseq": "T2R107; taste receptor T2R4; taste receptor type 2 member 107; taste receptor type 2 member 4; taste receptor, type 2, member 10", "tax_id": 10116, "disease": "", "pathway": " (rno:78981); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10761934;21303656;23070743", "class_list": "", "function": "Gene expression frequency of TAS2R40 and TAS2R107 on the tongue significantly decreased in rats fed a zinc-deficient diet, and frequency of TAS2R107 significantly increased following zinc administration., [RefSeq, PubMed]; Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]; T2R4 is localized in the neuronal cells of the rat brain stem., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9JKT9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKT8-1", "uniprot_id": [ { "id": "TR114_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKT8", "type": "external" } ], "mass": 35604.0, "length": 309, "protein_name": "Taste receptor type 2 member 114", "gene_name": "Tas2r114", "organism": "Rat", "refseq_name": "taste receptor type 2 member 114", "refseq_ac": [ { "id": "NP_076486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076486", "type": "external" } ], "gene_names_uniprotkb": "Tas2r114; Tas2r5", "gene_names_refseq": "T2R5; Tas2r114; Tas2r5", "protein_names_uniprotkb": "Taste receptor type 2 member 114; T2R114; T2R5; Taste receptor type 2 member 5", "protein_names_refseq": "T2R114; taste receptor T2R5; taste receptor type 2 member 114; taste receptor type 2 member 5", "tax_id": 10116, "disease": "", "pathway": " (rno:78982)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10761934", "class_list": "", "function": "Putative taste receptor which may play a role in the perception of bitterness., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JKT8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JLN4-1", "uniprot_id": [ { "id": "PGRP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JLN4", "type": "external" } ], "mass": 20591.0, "length": 183, "protein_name": "Peptidoglycan recognition protein 1", "gene_name": "Pglyrp1", "organism": "Rat", "refseq_name": "peptidoglycan recognition protein 1 precursor", "refseq_ac": [ { "id": "NP_445825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445825", "type": "external" } ], "gene_names_uniprotkb": "Pglyrp1; Pglyrp; Pgrp", "gene_names_refseq": "Pglyrp1; Pglyrp; Pgrp", "protein_names_uniprotkb": "Peptidoglycan recognition protein 1; PGRP-S; Peptidoglycan recognition protein short", "protein_names_refseq": "PGRP-S; peptidoglycan recognition protein 1 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:84387); (R-RNO-6798695); (R-RNO-6803157)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11145837;16641100", "class_list": "", "function": "Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0032827 negative regulation of natural killer cell differentiation involved in immune response;GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JLN4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923S8-1", "uniprot_id": [ { "id": "PANK4_RAT", "url": "https://www.uniprot.org/uniprot/Q923S8", "type": "external" } ], "mass": 86243.0, "length": 773, "protein_name": "4'-phosphopantetheine phosphatase", "gene_name": "Pank4", "organism": "Rat", "refseq_name": "4'-phosphopantetheine phosphatase", "refseq_ac": [ { "id": "NP_598215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598215", "type": "external" } ], "gene_names_uniprotkb": "Pank4; Fang1", "gene_names_refseq": "Fang1; Pank4", "protein_names_uniprotkb": "4'-phosphopantetheine phosphatase; 3.1.3.-; Inactive pantothenic acid kinase 4; rPanK4", "protein_names_refseq": "4'-phosphopantetheine phosphatase; hypothetical protein Fang1; inactive pantothenic acid kinase 4; pantothenate kinase 4 (inactive); pantothenic acid kinase 4; rPanK4", "tax_id": 10116, "disease": "pantothenate kinase-associated neurodegeneration (Disease Ontology:DOID:3981); cataract (Disease Ontology:DOID:83)", "pathway": " (rno:171053); (R-RNO-199220)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16132722;17971806;22673903", "class_list": "", "function": "PanK4 inhibits pancreatic beta-cell apoptosis by decreasing the transcriptional level of pro-caspase-9, [RefSeq, PubMed]; PanK4 interacts with Pkm2 and thereby may modulate the glucose metabolism through regulating the activity of Pkm2., [RefSeq, PubMed]; Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016791 phosphatase activity;GO:0016787 hydrolase activity;GO:0004594 pantothenate kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q923S8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R006-1", "uniprot_id": [ { "id": "PR7A2_RAT", "url": "https://www.uniprot.org/uniprot/Q9R006", "type": "external" } ], "mass": 28882.0, "length": 250, "protein_name": "Prolactin-7A2", "gene_name": "Prl7a2; Prl7a3", "organism": "Rat", "refseq_name": "prolactin-7A2 precursor", "refseq_ac": [ { "id": "NP_071975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071975", "type": "external" } ], "gene_names_uniprotkb": "Prl7a2; Prl7a3; Prl7a3; Prlpf", "gene_names_refseq": "Ghd7; Prl7a2; Prl7a3; Prlfp; Prlpf", "protein_names_uniprotkb": "Prolactin-7A2; PLP-F; PRL-like protein F; Placental prolactin-like protein F", "protein_names_refseq": "PLP-F; PRL-like protein F; growth hormone d7; placental prolactin-like protein F; prolactin-7A2 precursor; prolactin-7A2", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); impulse control disorder (Disease Ontology:DOID:10937); depressive disorder (Disease Ontology:DOID:1596); severe acute respiratory syndrome (Disease Ontology:DOID:2945); carotid artery disease (Disease Ontology:DOID:3407); prolactinoma (Disease Ontology:DOID:5394); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:64361)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10657001;17095594", "class_list": "", "function": "Adaptive responses to maternal hypoxia include activation of placental PLP-Falpha/E gene expression, which may then participate in maternal hematological adjustments required for maintaining maternal and fetal oxygen delivery., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9R006-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JI85-1", "uniprot_id": [ { "id": "NUCB2_RAT", "url": "https://www.uniprot.org/uniprot/Q9JI85", "type": "external" } ], "mass": 50090.0, "length": 420, "protein_name": "Nucleobindin-2", "gene_name": "Nucb2", "organism": "Rat", "refseq_name": "nucleobindin-2 precursor", "refseq_ac": [ { "id": "NP_067695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067695", "type": "external" } ], "gene_names_uniprotkb": "Nucb2; Nefa", "gene_names_refseq": "Nefa; Nucb2; p54", "protein_names_uniprotkb": "Nucleobindin-2; DNA-binding protein NEFA; Prepronesfatin", "protein_names_refseq": "DNA-binding protein NEFA; nesfatin-1; nucleobindin-2 precursor; prepronefastin; prepronesfatin", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:59295)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "11893086;15240697;17036007;21653697;22293188;22673903;37031608;37105355;38339201;38511245;39097921", "class_list": "", "function": "A research on the expression of Nucb2/ cAMP / PKA in the hippocampus of alcohol-dependent rats., [RefSeq, PubMed]; Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G protein) alpha subunit GNAI3 (PubMed:21653697)., [UniProtKB, PubMed, UniProtKB]; Nesfatin, corresponding to NEFA/nucleobindin2 (NUCB2), a secreted protein of unknown function, is expressed in the appetite-control hypothalamic nuclei in rats, [RefSeq, PubMed]; Nesfatin-1 alleviates hyperoxia-induced bronchopulmonary dysplasia (BPD) via the nuclear factor-kappaB (NF-kappaB) p65 signaling pathway., [RefSeq, PubMed]; Nesfatin-1 inhibits cerebral aneurysms by activating Nrf2 and inhibiting NF-kappaB signaling., [RefSeq, PubMed]; Nesfatin-1 peptide protects rat renal epithelial cells against high glucose and H2O2 induced injury via inhibition of oxidative stress, apoptosis, and fibrosis., [RefSeq, PubMed]; Nuclear Binding Protein 2/Nesfatin-1 Affects Trophoblast Cell Fusion during Placental Development via the EGFR-PLCG1-CAMK4 Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Since NEFA is a peripheral luminal membrane constituent, its distinct trafficking from the transmembrane marker mannosidase II suggests a novel Golgi retention mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005509 calcium ion binding;GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1901142 insulin metabolic process;GO:0042594 response to starvation;GO:0007264 small GTPase-mediated signal transduction;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9JI85-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920E0-1", "uniprot_id": [ { "id": "PAR4_RAT", "url": "https://www.uniprot.org/uniprot/Q920E0", "type": "external" } ], "mass": 42943.0, "length": 395, "protein_name": "Proteinase-activated receptor 4", "gene_name": "F2rl3", "organism": "Rat", "refseq_name": "proteinase-activated receptor 4", "refseq_ac": [ { "id": "NP_446260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446260", "type": "external" } ], "gene_names_uniprotkb": "F2rl3; Par4", "gene_names_refseq": "F2rl3; PAR4", "protein_names_uniprotkb": "Proteinase-activated receptor 4; Coagulation factor II receptor-like 3; PAR-4; Thrombin receptor-like 3", "protein_names_refseq": "F2R like thrombin/trypsin receptor 3; G-protein coupled receptor; PAR-4; coagulation factor II (thrombin) receptor-like 3; coagulation factor II receptor-like 3; protease-activated receptor 4; proteinase-activated receptor 4; thrombin receptor-like 3", "tax_id": 10116, "disease": "", "pathway": " (rno:116498); (R-RNO-375276); (R-RNO-416476); (R-RNO-456926)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "16403464;17136598;20875131;24105611;25931468;35093640", "class_list": "", "function": "Activation of PAR4 upregulates the expression of CGRP mRNA and protein levels in dorsal root ganglion neurons, [RefSeq, PubMed]; Blocking protease-activated receptor 4 alleviates liver injury induced by brain death., [RefSeq, PubMed]; Increased thrombin activity 6 to 24 hours after germinal matrix hemorrhage, and PAR-1, PAR-4, inhibition normalized cyclooxygenase-2, and mammalian target of rapamycin by 72 hours., [RefSeq, PubMed]; PAR 4 is regulated at the transcriptional level in a rat model of lipopolysaccharide induced acute lung injury and probably has a distinct role., [RefSeq, PubMed]; PAR1 and PAR3 could be involved in thrombin-modulated initiation of post-ischemic inflammation and PAR4 may be associated with neuronal degeneration. (Protease-activated receptor 1, 3, 4), [RefSeq, PubMed]; PAR1 and PAR4 are functionally expressed in large myelinated fibre neurons, and are also expressed in small nociceptors of the peptidergic subclass, where they are able to potentiate TRPV1 activity. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015057 thrombin-activated receptor activity;GO:0002020 protease binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0030168 platelet activation;GO:0051281 positive regulation of release of sequestered calcium ion into cytosol;GO:0070527 platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q920E0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O88777-1", "uniprot_id": [ { "id": "PSN2_RAT", "url": "https://www.uniprot.org/uniprot/O88777", "type": "external" } ], "mass": 50051.0, "length": 448, "protein_name": "Presenilin-2", "gene_name": "Psen2", "organism": "Rat", "refseq_name": "presenilin-2", "refseq_ac": [ { "id": "NP_112349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112349", "type": "external" } ], "gene_names_uniprotkb": "Psen2; Ps2; Psnl2", "gene_names_refseq": "Psen2", "protein_names_uniprotkb": "Presenilin-2; 3.4.23.-; PS-2", "protein_names_refseq": "PS-2; presenilin-2", "tax_id": 10116, "disease": "early-onset Parkinson's disease (Disease Ontology:DOID:0060894); Alzheimer's disease 4 (Disease Ontology:DOID:0110040); Alzheimer's disease 3 (Disease Ontology:DOID:0110042); dilated cardiomyopathy 1V (Disease Ontology:DOID:0110427); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); dilated cardiomyopathy (Disease Ontology:DOID:12930); breast cancer (Disease Ontology:DOID:1612)", "pathway": " (rno:81751); (R-RNO-1251985); (R-RNO-193692); (R-RNO-205043); (R-RNO-3928665); (R-RNO-9013507); (R-RNO-9017802); (R-RNO-9839383)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "21285369;22673903;26721367;27804997;9332390;9545577", "class_list": "", "function": "Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (By similarity). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369)., [UniProtKB, PubMed, UniProtKB]; Downregulating the expression of miR-375, miR-30a, and miR-34a restored PSEN1, PSEN2, and NICD1 production and prevented glucotoxicity-induced impairment of the beta cells.Our findings demonstrated that miRNA-mediated suppression of NICD1 links the presenilin/Notch1 pathway to glucotoxicity in mature pancreatic beta cells Publication Status: Online-Only, [RefSeq, PubMed]; Significant dysregulation of presenilin 2 gene was found in neuronal cells following brain ischemia due to cardiac arrest., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O08947;O35546", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0002573 myeloid leukocyte differentiation;GO:0001708 cell fate specification;GO:0035333 Notch receptor processing, ligand-dependent;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006509 membrane protein ectodomain proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O88777-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XU1-1", "uniprot_id": [ { "id": "QKI_RAT", "url": "https://www.uniprot.org/uniprot/Q91XU1", "type": "external" } ], "mass": 37643.0, "length": 341, "protein_name": "KH domain-containing RNA-binding protein QKI", "gene_name": "Qki", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Qki; Qk", "gene_names_refseq": "", "protein_names_uniprotkb": "KH domain-containing RNA-binding protein QKI; Protein quaking; RqkI", "protein_names_refseq": "", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:499022)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11178867", "class_list": "", "function": "RNA reader protein, which recognizes and binds specific RNAs, thereby regulating RNA metabolic processes, such as pre-mRNA splicing, circular RNA (circRNA) formation, mRNA export, mRNA stability and/or translation. Involved in various cellular processes, such as mRNA storage into stress granules, apoptosis, lipid deposition, interferon response, glial cell fate and development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts as a mRNA modification reader that specifically recognizes and binds mRNA transcripts modified by internal N(7)-methylguanine (m7G). Promotes the formation of circular RNAs (circRNAs) during the epithelial to mesenchymal transition and in cardiomyocytes: acts by binding to sites flanking circRNA-forming exons. CircRNAs are produced by back-splicing circularization of pre-mRNAs. Plays a central role in myelinization via 3 distinct mechanisms (By similarity). First, acts by protecting and promoting stability of target mRNAs such as MBP, SIRT2 and CDKN1B, which promotes oligodendrocyte differentiation. Second, participates in mRNA transport by regulating the nuclear export of MBP mRNA. Finally, indirectly regulates mRNA splicing of MAG pre-mRNA during oligodendrocyte differentiation by acting as a negative regulator of MAG exon 12 alternative splicing: acts by binding to HNRNPA1 mRNA splicing factor, preventing its translation. Involved in microglia differentiation and remyelination by regulating microexon alternative splicing of the Rho GTPase pathway (By similarity). Involved in macrophage differentiation: promotes monocyte differentiation by regulating pre-mRNA splicing in naive peripheral blood monocytes (By similarity). Acts as an important regulator of muscle development: required for the contractile function of cardiomyocytes by regulating alternative splicing of cardiomyocyte transcripts. Acts as a negative regulator of thermogenesis by decreasing stability, nuclear export and translation of mRNAs encoding PPARGC1A and UCP1. Also required for visceral endoderm function and blood vessel development (By similarity). May also play a role in smooth muscle development (By similarity). In addition to its RNA-binding activity, also acts as a nuclear transcription coactivator for SREBF2/SREBP2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003729 mRNA binding;GO:0017124 SH3 domain binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0035886 vascular associated smooth muscle cell differentiation;GO:0001570 vasculogenesis;GO:0006397 mRNA processing;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91XU1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91XV7-1", "uniprot_id": [ { "id": "TM158_RAT", "url": "https://www.uniprot.org/uniprot/Q91XV7", "type": "external" } ], "mass": 29005.0, "length": 285, "protein_name": "Transmembrane protein 158", "gene_name": "Tmem158", "organism": "Rat", "refseq_name": "transmembrane protein 158 precursor", "refseq_ac": [ { "id": "NP_476560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476560", "type": "external" } ], "gene_names_uniprotkb": "Tmem158; Ris1", "gene_names_refseq": "Ris1; Tmem158", "protein_names_uniprotkb": "Transmembrane protein 158; 40 kDa BINP-binding protein; Brain-specific binding protein; Ras-induced senescence protein 1; p40BBP", "protein_names_refseq": "40 kDa BINP-binding protein; BINP receptor; Ras-induced senescence 1; brain-specific binding protein; p40BBP; ras-induced senescence protein 1; transmembrane protein 158 precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:117582)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11399754", "class_list": "", "function": "Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042277 peptide binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91XV7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91Z63-1", "uniprot_id": [ { "id": "TRI63_RAT", "url": "https://www.uniprot.org/uniprot/Q91Z63", "type": "external" } ], "mass": 39723.0, "length": 351, "protein_name": "E3 ubiquitin-protein ligase TRIM63", "gene_name": "Trim63", "organism": "Rat", "refseq_name": "E3 ubiquitin-protein ligase TRIM63", "refseq_ac": [ { "id": "NP_543179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_543179", "type": "external" } ], "gene_names_uniprotkb": "Trim63; Murf1", "gene_names_refseq": "Murf1; Murf; Rnf28; Trim63", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM63; 2.3.2.27; MuRF-1; MuRF1; Muscle-specific RING finger protein 1; RING-type E3 ubiquitin transferase TRIM63; Tripartite motif-containing protein 63", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM63; MURF-1; RING-type E3 ubiquitin transferase TRIM63; monomeric E3 ubiquitin ligase; muscle ring finger protein 1; muscle-specific RING finger protein 1; ring finger protein 28; tripartite motif containing 63, E3 ubiquitin protein ligase; tripartite motif protein 63; tripartite motif-containing protein 63", "tax_id": 10116, "disease": "primary pulmonary hypertension (Disease Ontology:DOID:14557); muscular atrophy (Disease Ontology:DOID:767); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (rno:140939); (R-RNO-983168)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "11679633;11927605;12672461;12782319;14718385;15596539;15827064;15963672;32646070;34943780;35301823;36414561;37658726", "class_list": "", "function": "Differences in the Role of HDACs 4 and 5 in the Modulation of Processes Regulating MAFbx and MuRF1 Expression during Muscle Unloading. Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells., [UniProtKB, PubMed, PubMed]; Leucine-Rich Diet Improved Muscle Function in Cachectic Walker 256 Tumour-Bearing Wistar Rats. Publication Status: Online-Only, [RefSeq, PubMed]; MafBx and Murf mRNA are up-regulated in response to LPS and might play a role in the muscle proteolysis observed, [RefSeq, PubMed]; MuRF-1 is Involved in Laryngeal Muscle Denervation Atrophy by Regulating G-Actin Ubiquitination., [RefSeq, PubMed]; Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility., [RefSeq, PubMed]; [Effects of different types of exercise on contractile properties and expressions of MuRF1, PGC-1alpha /FNDC5 in soleus muscle of unloaded rats]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031432 titin binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030018 Z disc;GO:0031430 M band;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0014904 myotube cell development;GO:0006936 muscle contraction;GO:0045087 innate immune response;GO:0051384 response to glucocorticoid;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q91Z63-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920A6-1", "uniprot_id": [ { "id": "RISC_RAT", "url": "https://www.uniprot.org/uniprot/Q920A6", "type": "external" } ], "mass": 51175.0, "length": 452, "protein_name": "Retinoid-inducible serine carboxypeptidase", "gene_name": "Scpep1", "organism": "Rat", "refseq_name": "retinoid-inducible serine carboxypeptidase precursor", "refseq_ac": [ { "id": "NP_596874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596874", "type": "external" } ], "gene_names_uniprotkb": "Scpep1; Risc", "gene_names_refseq": "Risc; Scpep1", "protein_names_uniprotkb": "Retinoid-inducible serine carboxypeptidase; 3.4.16.-; Serine carboxypeptidase 1", "protein_names_refseq": "retinoid-inducible serine carboxypeptidase precursor; retinoid-inducible serine carboxypeptidase; retinoid-inducible serine caroboxypetidase", "tax_id": 10116, "disease": "", "pathway": " (rno:114861)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11447226;29393594", "class_list": "", "function": "May be involved in vascular wall and kidney homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004185 serine-type carboxypeptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0045776 negative regulation of blood pressure;GO:0097746 blood vessel diameter maintenance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q920A6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q920I0-1", "uniprot_id": [ { "id": "PR8A9_RAT", "url": "https://www.uniprot.org/uniprot/Q920I0", "type": "external" } ], "mass": 27736.0, "length": 241, "protein_name": "Prolactin-8A9", "gene_name": "Prl8a9", "organism": "Rat", "refseq_name": "prolactin-8A9 precursor", "refseq_ac": [ { "id": "NP_599212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599212", "type": "external" } ], "gene_names_uniprotkb": "Prl8a9; Prlpc2", "gene_names_refseq": "Ghd9; Plpcbeta; Prl8a9; Prlpc2", "protein_names_uniprotkb": "Prolactin-8A9; PLP C-beta; PLP-C2; PRL-like protein C2; Placental prolactin-like protein C2; Prolactin-like protein C-beta", "protein_names_refseq": "PLP C-beta; PLP-C2; PRL-like protein C2; growth hormone d9; placental prolactin-like protein C2; prolactin-8A9 precursor; prolactin-8A9; prolactin-like protein C 2; prolactin-like protein C-beta", "tax_id": 10116, "disease": "", "pathway": " (rno:171406)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10965907", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1L118;Q498N7;Q80ZD4;Q920H9", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q920I0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q923Y2-1", "uniprot_id": [ { "id": "TAA7A_RAT", "url": "https://www.uniprot.org/uniprot/Q923Y2", "type": "external" } ], "mass": 40147.0, "length": 358, "protein_name": "Trace amine-associated receptor 7a", "gene_name": "Taar7a", "organism": "Rat", "refseq_name": "trace amine-associated receptor 7a", "refseq_ac": [ { "id": "NP_783175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783175", "type": "external" } ], "gene_names_uniprotkb": "Taar7a; Ta8; Tar8; Trar8", "gene_names_refseq": "Ta8; Taar7a", "protein_names_uniprotkb": "Trace amine-associated receptor 7a; TaR-7a; TaR-8; Trace amine receptor 7a; Trace amine receptor 8", "protein_names_refseq": "taR-7a; taR-8; trace amine receptor 7a; trace amine receptor 8; trace amine-associated receptor 7a", "tax_id": 10116, "disease": "", "pathway": " (rno:294125)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11459929;17556730", "class_list": "", "function": "Olfactory receptor specific for N,N-dimethylalkylamines trace amines. Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors. Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS)., [UniProtKB, UniProtKB]; Shows that expression of Taar family members is limited to specific tissue subpopulations and developmental stages in mouse., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001594 trace-amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q923Y2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q924C9-1", "uniprot_id": [ { "id": "S26A3_RAT", "url": "https://www.uniprot.org/uniprot/Q924C9", "type": "external" } ], "mass": 83369.0, "length": 757, "protein_name": "Chloride anion exchanger", "gene_name": "Slc26a3", "organism": "Rat", "refseq_name": "chloride anion exchanger", "refseq_ac": [ { "id": "NP_446207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446207", "type": "external" } ], "gene_names_uniprotkb": "Slc26a3; Dra", "gene_names_refseq": "Slc26a3", "protein_names_uniprotkb": "Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3", "protein_names_refseq": "chloride anion exchanger; down-regulated in adenoma; solute carrier family 26 (anion exchanger), member 3", "tax_id": 10116, "disease": "congenital secretory chloride diarrhea 1 (Disease Ontology:DOID:0060296); diarrhea (Disease Ontology:DOID:13250)", "pathway": " (rno:114629); (R-RNO-427601)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "17492310;25297603;35076190", "class_list": "", "function": "Data indicate that solute carrier family 26, member 3 protein (Slc26a3) is expressed in male reproductive tract, and its expression pattern is related to the function., [RefSeq, PubMed]; In addition to mediating pH-sensitive Cl(-) uptake, DRA may function as a modifier of other anion transport proteins, [RefSeq, PubMed]; MOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein, is an Alternative to BCECF-AM to Measure Intracellular pH to Determine NHE3 and DRA Activity., [RefSeq, PubMed]; Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015106 bicarbonate transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane;GO:0097225 sperm midpiece", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:0048240 sperm capacitation;GO:1902476 chloride transmembrane transport;GO:0060081 membrane hyperpolarization;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q924C9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99JE4-1", "uniprot_id": [ { "id": "RGRF2_RAT", "url": "https://www.uniprot.org/uniprot/Q99JE4", "type": "external" } ], "mass": 135827.0, "length": 1190, "protein_name": "Ras-specific guanine nucleotide-releasing factor 2", "gene_name": "AABR07007642.1; Rasgrf2", "organism": "Rat", "refseq_name": "ras-specific guanine nucleotide-releasing factor 2", "refseq_ac": [ { "id": "NP_446173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446173", "type": "external" } ], "gene_names_uniprotkb": "AABR07007642.1; Rasgrf2; AABR07007642.1; Grf2; Rasgrf2", "gene_names_refseq": "Rasgrf2", "protein_names_uniprotkb": "Ras-specific guanine nucleotide-releasing factor 2; Ras guanine nucleotide exchange factor 2; Ras-GRF2", "protein_names_refseq": "guanine nucleotide-releasing factor 2; ras guanine nucleotide exchange factor 2; ras-GRF2; ras-specific guanine nucleotide-releasing factor 2", "tax_id": 10116, "disease": "", "pathway": " (rno:114513); (R-RNO-193648); (R-RNO-416482); (R-RNO-5673001); (R-RNO-8980692); (R-RNO-9013148); (R-RNO-9013149)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "10373510;11252168;14749369;15128856;17931779;9032266", "class_list": "", "function": "Data identify the Ras activator, Ras-GRF1, although not Ras-GRF2, as a susceptible target to cocaine stimulation in striatal neurons, [RefSeq, PubMed]; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation., [UniProtKB, PubMed]; RasGRF family exchange factors, both endogenous and ectopically expressed, are present in the endoplasmic reticulum but not in the Golgi complex, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0098794 postsynapse", "go_biological_process": "GO:2000310 regulation of NMDA receptor activity;GO:0007265 Ras protein signal transduction;GO:0060291 long-term synaptic potentiation;GO:0034976 response to endoplasmic reticulum stress;GO:0099170 postsynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q99JE4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MS0-1", "uniprot_id": [ { "id": "S14L2_RAT", "url": "https://www.uniprot.org/uniprot/Q99MS0", "type": "external" } ], "mass": 46166.0, "length": 403, "protein_name": "SEC14-like protein 2", "gene_name": "Sec14l2", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sec14l2", "gene_names_refseq": "", "protein_names_uniprotkb": "SEC14-like protein 2; Alpha-tocopherol-associated protein; SPF; Squalene transfer protein; Supernatant protein factor; TAP", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:116486)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11226224", "class_list": "", "function": "Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol (By similarity). Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0008289 lipid binding;GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045542 positive regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99MS0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99MY2-1", "uniprot_id": [ { "id": "NUDT4_RAT", "url": "https://www.uniprot.org/uniprot/Q99MY2", "type": "external" } ], "mass": 20138.0, "length": 179, "protein_name": "Diphosphoinositol polyphosphate phosphohydrolase 2", "gene_name": "Nudt4; Ube2n", "organism": "Rat", "refseq_name": "diphosphoinositol polyphosphate phosphohydrolase 2 isoform 2", "refseq_ac": [ { "id": "NP_446050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446050", "type": "external" } ], "gene_names_uniprotkb": "Nudt4; Ube2n; Dipp2", "gene_names_refseq": "DRCF-5; Nudt4", "protein_names_uniprotkb": "Diphosphoinositol polyphosphate phosphohydrolase 2; 3.6.1.52; 3.6.1.61; DIPP-2; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2; Nucleoside diphosphate-linked moiety X motif 4; Nudix motif 4", "protein_names_refseq": "DIPP-2; diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2; diphosphoinositol polyphosphate phosphohydolase type II; diphosphoinositol polyphosphate phosphohydrolase 2 isoform 2; diphosphoinositol polyphosphate phosphohydrolase 2; nucleoside diphosphate-linked moiety X motif 4; nudix (nucleoside diphosphate linked moiety X)-type motif 4; nudix motif 4; nudix-type motif 4; rDIPP2", "tax_id": 10116, "disease": "", "pathway": " (rno:94267); (R-RNO-1855167)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11331144", "class_list": "", "function": "Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates. Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate (By similarity). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "3.6.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.52", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.10", "type": "external" }, { "id": "3.6.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.61", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0000298 endopolyphosphatase activity;GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity;GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity;GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity;GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0071543 diphosphoinositol polyphosphate metabolic process;GO:1901907 diadenosine pentaphosphate catabolic process;GO:1901909 diadenosine hexaphosphate catabolic process;GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99MY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q99PK0-1", "uniprot_id": [ { "id": "SYF1_RAT", "url": "https://www.uniprot.org/uniprot/Q99PK0", "type": "external" } ], "mass": 99998.0, "length": 855, "protein_name": "Pre-mRNA-splicing factor SYF1", "gene_name": "Xab2", "organism": "Rat", "refseq_name": "pre-mRNA-splicing factor SYF1", "refseq_ac": [ { "id": "NP_620809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620809", "type": "external" } ], "gene_names_uniprotkb": "Xab2; Ath55; Syf1", "gene_names_refseq": "Ath55; Xab2", "protein_names_uniprotkb": "Pre-mRNA-splicing factor SYF1; Adapter protein ATH-55; XPA-binding protein 2", "protein_names_refseq": "adapter protein ATH-55; pre-mRNA-splicing factor SYF1", "tax_id": 10116, "disease": "", "pathway": " (rno:245976); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210); (R-RNO-72163)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "12801913", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0071013 catalytic step 2 spliceosome;GO:0071014 post-mRNA release spliceosomal complex", "go_biological_process": "GO:0000349 generation of catalytic spliceosome for first transesterification step;GO:0006351 DNA-templated transcription;GO:0021987 cerebral cortex development;GO:0000398 mRNA splicing, via spliceosome;GO:0006283 transcription-coupled nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q99PK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPH0-1", "uniprot_id": [ { "id": "S26A5_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPH0", "type": "external" } ], "mass": 81279.0, "length": 744, "protein_name": "Prestin", "gene_name": "Slc26a5", "organism": "Rat", "refseq_name": "prestin", "refseq_ac": [ { "id": "NP_110467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110467", "type": "external" } ], "gene_names_uniprotkb": "Slc26a5; Pres", "gene_names_refseq": "Pres; Slc26a5; prestin", "protein_names_uniprotkb": "Prestin; Solute carrier family 26 member 5", "protein_names_refseq": "prestin (motor protein); prestin; solute carrier family 26 (anion exchanger), member 5", "tax_id": 10116, "disease": "autosomal recessive nonsyndromic deafness 61 (Disease Ontology:DOID:0110513); hypothyroidism (Disease Ontology:DOID:1459)", "pathway": " (rno:83819)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "11125015;11274441;11423665;11867734;12782792;17442754;20471983;22063625;22890707;24710176;26635354;27636386;28097024;30529910;33667636", "class_list": "", "function": "Calmodulin binds to the STAS domain of SLC26A5 prestin with a calcium-dependent, one-lobe, binding mode., [RefSeq, PubMed]; In chicken STAS, the anion-binding site is lacking because of a local structural rearrangement, indicating that the presence of the STAS anion-binding site is exclusive to mammalian prestin, [RefSeq, PubMed]; Prestin expression first appeared at postnatal day 6 (P6) in the auditory brainstem and reached mature level by P14., [RefSeq, PubMed]; These results suggest that there is a temporal pattern of change in serum prestin level after noise-induced hearing loss that is related to severity of hearing loss. Circulatory levels of prestin may be able to act as surrogate biomarker for hearing loss involving outer hair cell loss., [RefSeq, PubMed]; Voltage-sensitive motor protein that drives outer hair cell (OHC) electromotility (eM) and participates in sound amplification in the hearing organ (PubMed:11125015, PubMed:11274441). Converts changes in the transmembrane electric potential into mechanical displacements resulting in the coupling of its expansion to movement of a charged voltage sensor across the lipid membrane (PubMed:11125015, PubMed:11274441). The nature of the voltage sensor is not completely clear, and two models compete. In the first model, acts as an incomplete transporter where intracellular chloride anion acts as extrinsic voltage sensor that drives conformational change in the protein which is sufficient to produce a length change in the plane of the membrane and hence in the length of the OHC (PubMed:11423665). The second model in which multiple charged amino acid residues are distributed at the intracellular and extracellular membrane interfaces that form an intrinsic voltage sensor, whose movement produces the non-linear capacitance (NLC) (By similarity). However, the effective voltage sensor may be the result of a hybrid voltage sensor assembled from intrinsic charge (charged residues) and extrinsic charge (bound anion) (By similarity). Notably, binding of anions to the anion-binding pocket partially neutralizes the intrinsic positive charge rather than to form an electrically negative sensor, therefore remaining charge may serve as voltage sensor that, after depolarization, moves from down (expanded state) to up (contracted) conformation, which is accompanied by an eccentric contraction of the intermembrane cross-sectional area of the protein as well as a major increase in the hydrophobic thickness of the protein having as consequences the plasma membrane thickening and the cell contraction after membrane depolarization (By similarity). The anion-binding pocket transits from the inward-open (Down) state, where it is exposed toward the intracellular solvent in the absence of anion, to the occluded (Up) state upon anion binding (PubMed:24710176). Salicylate competes for the anion-binding site and inhibits the voltage-sensor movement, and therefore inhibits the charge transfer and electromotility by displacing Cl(-) from the anion-binding site and by preventing the structural transitions to the contracted state (By similarity). In addition, can act as a weak Cl(-)/HCO3(-) antiporter across the cell membrane and so regulate the intracellular pH of the outer hair cells (OHCs) (PubMed:22063625, PubMed:22890707), while firstly found as being unable to mediate electrogenic anion transport (PubMed:17442754, PubMed:22063625, PubMed:22890707). Moreover, supports a role in cardiac mechanical amplification serving as an elastic element to enhance the actomyosin- based sarcomere contraction system (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Work, for the first time, provides proof of concept that the levels of prestin, an otologic serum biomarker, can change after acoustic trauma and hearing loss, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 39, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9ERC6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0030507 spectrin binding;GO:0019531 oxalate transmembrane transporter activity;GO:0003774 cytoskeletal motor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016328 lateral plasma membrane;GO:0120249 lateral wall of outer hair cell;GO:0016020 membrane", "go_biological_process": "GO:0098656 monoatomic anion transmembrane transport;GO:0019532 oxalate transport;GO:0002931 response to ischemia;GO:0042391 regulation of membrane potential;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9EPH0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EPJ3-1", "uniprot_id": [ { "id": "RT26_RAT", "url": "https://www.uniprot.org/uniprot/Q9EPJ3", "type": "external" } ], "mass": 23350.0, "length": 200, "protein_name": "Small ribosomal subunit protein mS26", "gene_name": "Mrps26", "organism": "Rat", "refseq_name": "small ribosomal subunit protein mS26 precursor", "refseq_ac": [ { "id": "NP_001013224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013224", "type": "external" } ], "gene_names_uniprotkb": "Mrps26", "gene_names_refseq": "Mrps26", "protein_names_uniprotkb": "Small ribosomal subunit protein mS26; 28S ribosomal protein S26, mitochondrial; MRP-S26; Protein 5'OT-EST; S26mt", "protein_names_refseq": "28S ribosomal protein S26, mitochondrial; 5'OT-EST protein; MRP-S26; S26mt; protein 5'OT-EST; small ribosomal subunit protein mS26 precursor; small ribosomal subunit protein mS26", "tax_id": 10116, "disease": "", "pathway": " (rno:362216); (R-RNO-5389840); (R-RNO-5419276); (R-RNO-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9857009", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9EPJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQL5-1", "uniprot_id": [ { "id": "T4S4_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQL5", "type": "external" } ], "mass": 21484.0, "length": 202, "protein_name": "Transmembrane 4 L6 family member 4", "gene_name": "Tm4sf4", "organism": "Rat", "refseq_name": "transmembrane 4 L6 family member 4", "refseq_ac": [ { "id": "NP_446237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446237", "type": "external" } ], "gene_names_uniprotkb": "Tm4sf4; Lrtm4", "gene_names_refseq": "Lrtm4; Tm4sf4", "protein_names_uniprotkb": "Transmembrane 4 L6 family member 4", "protein_names_refseq": "transmembrane 4 L6 family member 4; transmembrane 4 superfamily member 4", "tax_id": 10116, "disease": "", "pathway": " (rno:116467)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11267677;17069928", "class_list": "", "function": "Rat TM4SF4 is overexpressed in acutely injured liver induced by CCl4 and plays a crucial role in accelerating liver injury, which may be mediated by the TNF-alpha and HGF/c-met signaling pathways., [RefSeq, PubMed]; Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0042246 tissue regeneration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9EQL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9EQP5-1", "uniprot_id": [ { "id": "PRELP_RAT", "url": "https://www.uniprot.org/uniprot/Q9EQP5", "type": "external" } ], "mass": 43179.0, "length": 377, "protein_name": "Prolargin", "gene_name": "Prelp", "organism": "Rat", "refseq_name": "prolargin precursor", "refseq_ac": [ { "id": "NP_445837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445837", "type": "external" } ], "gene_names_uniprotkb": "Prelp", "gene_names_refseq": "Prelp", "protein_names_uniprotkb": "Prolargin; Proline-arginine-rich end leucine-rich repeat protein", "protein_names_refseq": "prolargin precursor; prolargin; proline arginine-rich end leucine-rich repeat protein-like; proline-arginine-rich end leucine-rich repeat protein", "tax_id": 10116, "disease": "", "pathway": " (rno:84400); (R-RNO-2022854); (R-RNO-2022857)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11007795;20096814;26920026", "class_list": "", "function": "May anchor basement membranes to the underlying connective tissue., [UniProtKB, UniProtKB]; Prelp were present exclusively in the proliferative zone of in growth plate cartilage of 1-week-old rats., [RefSeq, PubMed]; These findings provide support for a role of the N-terminal region of PRELP as an important regulator of cell adhesion and behaviour, which may be of importance in pathological conditions., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0090398 cellular senescence", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9EQP5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES38-1", "uniprot_id": [ { "id": "S27A5_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES38", "type": "external" } ], "mass": 76266.0, "length": 690, "protein_name": "Long-chain fatty acid transport protein 5", "gene_name": "Slc27a5", "organism": "Rat", "refseq_name": "long-chain fatty acid transport protein 5", "refseq_ac": [ { "id": "NP_077057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077057", "type": "external" } ], "gene_names_uniprotkb": "Slc27a5; Acsb; Fatp5; Vlacsr", "gene_names_refseq": "BAL; Slc27a5; rBAL-1", "protein_names_uniprotkb": "Long-chain fatty acid transport protein 5; 6.2.1.-; 6.2.1.3; 6.2.1.7; BA-CoA ligase; BACS; BAL; Bile acid-CoA ligase; Bile acyl-CoA synthetase; Cholate--CoA ligase; FATP-5; Fatty acid transport protein 5; Long-chain-fatty-acid--CoA ligase; Solute carrier family 27 member 5; VLACS-related; VLACSR; Very long-chain acyl-CoA synthetase-related protein", "protein_names_refseq": "BA-CoA ligase; BACS; FATP-5; VLACS-related; VLACSR; bile acid-CoA ligase; bile acyl-CoA synthetase; cholate--CoA ligase; fatty acid transport protein 5; long-chain fatty acid transport protein 5; long-chain-fatty-acid--CoA ligase; solute carrier family 27 (fatty acid transporter), member 5; very long-chain acyl-CoA synthetase-related protein", "tax_id": 10116, "disease": "", "pathway": " (rno:79111); (R-RNO-159418); (R-RNO-193368); (R-RNO-193775)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "12454267;12951368", "class_list": "", "function": "Mediates the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (By similarity). Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (By similarity). Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:12454267, PubMed:12951368). In particular, catalyzes the activation of the primary bile acid, chenodeoxycholic acid (PubMed:12454267, PubMed:12951368). Primary bile acid cholic acid and secondary bile acids (deoxycholic acid and lithocholic acid) are principal substrates too (By similarity). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (By similarity). Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "6.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.7", "type": "external" }, { "id": "6.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.24", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0015245 fatty acid transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0009925 basal plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006699 bile acid biosynthetic process;GO:0046951 ketone body biosynthetic process;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9ES38-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ES75-1", "uniprot_id": [ { "id": "PRAP1_RAT", "url": "https://www.uniprot.org/uniprot/Q9ES75", "type": "external" } ], "mass": 17322.0, "length": 152, "protein_name": "Proline-rich acidic protein 1", "gene_name": "Prap1", "organism": "Rat", "refseq_name": "proline-rich acidic protein 1 precursor", "refseq_ac": [ { "id": "NP_113857", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113857", "type": "external" } ], "gene_names_uniprotkb": "Prap1", "gene_names_refseq": "Prap1; Upa", "protein_names_uniprotkb": "Proline-rich acidic protein 1", "protein_names_refseq": "proline-rich acidic protein 1 precursor; uterine-specific proline-rich acidic protein", "tax_id": 10116, "disease": "", "pathway": " (rno:60574)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10899595", "class_list": "", "function": "Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity). May play an important role in maintaining normal growth homeostasis in epithelial cells (By similarity). Involved in p53/TP53-dependent cell survival after DNA damage (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017129 triglyceride binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:1902426 deactivation of mitotic spindle assembly checkpoint;GO:0043066 negative regulation of apoptotic process;GO:0006974 DNA damage response;GO:0030330 DNA damage response, signal transduction by p53 class mediator;GO:0071481 cellular response to X-ray", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9ES75-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9ET64-1", "uniprot_id": [ { "id": "NSMA_RAT", "url": "https://www.uniprot.org/uniprot/Q9ET64", "type": "external" } ], "mass": 47645.0, "length": 422, "protein_name": "Sphingomyelin phosphodiesterase 2", "gene_name": "Smpd2", "organism": "Rat", "refseq_name": "sphingomyelin phosphodiesterase 2", "refseq_ac": [ { "id": "NP_112650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112650", "type": "external" } ], "gene_names_uniprotkb": "Smpd2", "gene_names_refseq": "Smpd2; nSMase", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase 2; 3.1.4.12; Lyso-PAF-PLC; Lyso-platelet-activating factor-phospholipase C; N-SMase; Neutral sphingomyelinase; nSMase", "protein_names_refseq": "N-SMase; lyso-PAF-PLC; lyso-platelet-activating factor-phospholipase C; neutral sphingomyelinase; sphingomyelin phosphodiesterase 2, neutral membrane; sphingomyelin phosphodiesterase 2", "tax_id": 10116, "disease": "", "pathway": " (rno:83537); (R-RNO-5626978); (R-RNO-9840310)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10561609;10832103;12473648;24316227;25354938;28277984;29393594;34089907", "class_list": "", "function": "A novel physiological function as a new mechanosensor initiating the ERK cascade, [RefSeq, PubMed]; ANG II stimulates ceramide formation via the activation of nSMase in the kidney., [RefSeq, PubMed]; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor)., [UniProtKB, UniProtKB]; Characterization of neutral sphingomyelinase activity and isoform expression in rodent skeletal muscle mitochondria., [RefSeq, PubMed]; Data herein confirm the role of ceramide in increased apoptotic cell death and highlight the protective effect of N-SMase inhibition in down-regulation of apoptotic stimuli responses occurring in hepatic ischemia reperfusion injury., [RefSeq, PubMed]; Data suggest that neurotrophins can promote cell viability through Trk receptors in a manner depending on basal neutral sphingomyelinase (nSMase) but not through SMase activity enhancement., [RefSeq, PubMed]; Sphingomyelinase causes an increase in intracellular chloride, which is known to inhibit glycogen synthase phosphatase, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKB2", "ec_number_list": [ { "id": "3.1.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12", "type": "external" }, { "id": "3.1.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008081 phosphoric diester hydrolase activity;GO:0004767 sphingomyelin phosphodiesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0071944 cell periphery;GO:0005901 caveola", "go_biological_process": "GO:0030149 sphingolipid catabolic process;GO:0035556 intracellular signal transduction;GO:0046513 ceramide biosynthetic process;GO:0006672 ceramide metabolic process;GO:0009612 response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9ET64-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9HB97-1", "uniprot_id": [ { "id": "PARVA_RAT", "url": "https://www.uniprot.org/uniprot/Q9HB97", "type": "external" } ], "mass": 42292.0, "length": 372, "protein_name": "Alpha-parvin", "gene_name": "Parva", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Parva; Actp", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-parvin; Actopaxin", "protein_names_refseq": "", "tax_id": 10116, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (rno:57341); (R-RNO-446343); (R-RNO-446388)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "11134073;15817463;22673903;30515554", "class_list": "", "function": "Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019904 protein domain specific binding;GO:0044877 protein-containing complex binding;GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0007155 cell adhesion;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0034446 substrate adhesion-dependent cell spreading;GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9HB97-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JHW0-1", "uniprot_id": [ { "id": "PSB7_RAT", "url": "https://www.uniprot.org/uniprot/Q9JHW0", "type": "external" } ], "mass": 29927.0, "length": 277, "protein_name": "Proteasome subunit beta type-7", "gene_name": "Psmb7", "organism": "Rat", "refseq_name": "proteasome subunit beta type-7", "refseq_ac": [ { "id": "NP_445984", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445984", "type": "external" } ], "gene_names_uniprotkb": "Psmb7", "gene_names_refseq": "Psmb7", "protein_names_uniprotkb": "Proteasome subunit beta type-7; 3.4.25.1; Macropain chain Z; Multicatalytic endopeptidase complex chain Z; Proteasome subunit Z; Proteasome subunit beta-2; beta-2", "protein_names_refseq": "beta-2; macropain chain Z; multicatalytic endopeptidase complex chain Z; proteasome (prosome, macropain) subunit, beta type 7; proteasome beta 7 subunit; proteasome subunit Z; proteasome subunit beta 7; proteasome subunit beta type-7; proteasome subunit beta-2", "tax_id": 10116, "disease": "Omenn syndrome (Disease Ontology:DOID:0060010)", "pathway": " (rno:85492); (R-RNO-1169091); (R-RNO-1234176); (R-RNO-1236974); (R-RNO-1236978); (R-RNO-174084); (R-RNO-174113); (R-RNO-174154); (R-RNO-174178); (R-RNO-174184); (R-RNO-187577); (R-RNO-195253); (R-RNO-202424); (R-RNO-2467813); (R-RNO-2871837); (R-RNO-349425); (R-RNO-350562); (R-RNO-382556); (R-RNO-450408); (R-RNO-4608870); (R-RNO-4641257); (R-RNO-4641258); (R-RNO-5358346); (R-RNO-5607761); (R-RNO-5607764); (R-RNO-5610780); (R-RNO-5610785); (R-RNO-5632684); (R-RNO-5658442); (R-RNO-5668541); (R-RNO-5676590); (R-RNO-5687128); (R-RNO-5689603); (R-RNO-5689880); (R-RNO-6798695); (R-RNO-68867); (R-RNO-68949); (R-RNO-69017); (R-RNO-69481); (R-RNO-69601); (R-RNO-75815); (R-RNO-8852276); (R-RNO-8854050); (R-RNO-8939236); (R-RNO-8941858); (R-RNO-8948751); (R-RNO-8951664); (R-RNO-9020702); (R-RNO-9755511); (R-RNO-9762114); (R-RNO-9766229); (R-RNO-983168); (R-RNO-9907900); (R-RNO-9912633); (R-RNO-9929356); (R-RNO-9929491); (R-RNO-9931269); (R-RNO-9932298); (R-RNO-9954709)", "pathway_count": 59, "publication_count": 2, "publication_id_list": "22673903;23969338", "class_list": "", "function": "Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity., [UniProtKB, UniProtKB]; Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; Our results indicate that Psmb7 knockdown induces endoplasmic reticulum stress and autophagy in cardiomyocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.2.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "4.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.17", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "1.14.11.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.29", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JHW0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JII3-1", "uniprot_id": [ { "id": "PR2A1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JII3", "type": "external" } ], "mass": 25709.0, "length": 228, "protein_name": "Prolactin-2A1", "gene_name": "Prl2a1", "organism": "Rat", "refseq_name": "prolactin-2A1 precursor", "refseq_ac": [ { "id": "NP_446243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446243", "type": "external" } ], "gene_names_uniprotkb": "Prl2a1; Prlpm", "gene_names_refseq": "Ghd5; Prl2a1; Prlpm", "protein_names_uniprotkb": "Prolactin-2A1; PLP-M; PRL-like protein M; Placental prolactin-like protein M", "protein_names_refseq": "PLP-M; PRL-like protein M; growth hormone d5; placental prolactin-like protein M; prolactin-2A1 precursor; prolactin-2A1", "tax_id": 10116, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); withdrawal disorder (Disease Ontology:DOID:0060001); impulse control disorder (Disease Ontology:DOID:10937); depressive disorder (Disease Ontology:DOID:1596); severe acute respiratory syndrome (Disease Ontology:DOID:2945); carotid artery disease (Disease Ontology:DOID:3407); prolactinoma (Disease Ontology:DOID:5394); hepatocellular carcinoma (Disease Ontology:DOID:684); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (rno:116474)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10906059;12885563", "class_list": "", "function": "Both interstitial and endovascular rat trophoblast cells synthesize Prlpm., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JII3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JII4-1", "uniprot_id": [ { "id": "PR5A1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JII4", "type": "external" } ], "mass": 26162.0, "length": 227, "protein_name": "Prolactin-5A1", "gene_name": "Prl5a1", "organism": "Rat", "refseq_name": "prolactin-5A1 precursor", "refseq_ac": [ { "id": "NP_612536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612536", "type": "external" } ], "gene_names_uniprotkb": "Prl5a1; Prlpl", "gene_names_refseq": "Ghd1; Prl5a1; Prlpl", "protein_names_uniprotkb": "Prolactin-5A1; PLP-L; PRL-like protein L; Placental prolactin-like protein L", "protein_names_refseq": "PLP-L; PRL-like protein L; growth hormone d1; placental prolactin-like protein L; prolactin-5A1 precursor; prolactin-5A1", "tax_id": 10116, "disease": "", "pathway": " (rno:171556)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10471365;10906059", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0R7", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JII4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JJP6-1", "uniprot_id": [ { "id": "P63_RAT", "url": "https://www.uniprot.org/uniprot/Q9JJP6", "type": "external" } ], "mass": 76760.0, "length": 680, "protein_name": "Tumor protein 63", "gene_name": "Tp63", "organism": "Rat", "refseq_name": "tumor protein 63 isoform b", "refseq_ac": [ { "id": "NP_001120811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120811", "type": "external" } ], "gene_names_uniprotkb": "Tp63; Ket; P63; Tp73l; Trp63", "gene_names_refseq": "Ket; P73l; Tp63; Tp73l; Trp63", "protein_names_uniprotkb": "Tumor protein 63; Keratinocyte transcription factor KET; TP63; Transformation-related protein 63; Tumor protein p73-like; p63; p73L", "protein_names_refseq": "keratinocyte transcription factor KET; transformation related protein 63; tumor protein 63 isoform b; tumor protein 63 kDa", "tax_id": 10116, "disease": "ADULT syndrome (Disease Ontology:DOID:0050601); Rapp-Hodgkin syndrome (Disease Ontology:DOID:0060330); EEC syndrome (Disease Ontology:DOID:0060782); ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 (Disease Ontology:DOID:0060783); bladder exstrophy-epispadias-cloacal exstrophy complex (Disease Ontology:DOID:0080173); bladder exstrophy (Disease Ontology:DOID:0080174); orofacial cleft 8 (Disease Ontology:DOID:0080401); split hand-foot malformation 4 (Disease Ontology:DOID:0090023); ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (Disease Ontology:DOID:0090119); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); cancer (Disease Ontology:DOID:162); ectodermal dysplasia (Disease Ontology:DOID:2121); transitional cell carcinoma (Disease Ontology:DOID:2671); testicular cancer (Disease Ontology:DOID:2998); primary ovarian insufficiency (Disease Ontology:DOID:5426); gastroesophageal reflux disease (Disease Ontology:DOID:8534); prostate carcinoma in situ (Disease Ontology:DOID:8634); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)", "pathway": " (rno:246334); (R-RNO-6804759)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "11470269;9315105", "class_list": "", "function": "Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter (By similarity). Binds to an upstream regulatory region of the DSG1 gene and promotes transcription (By similarity)., [UniProtKB, PubMed, UniProtKB]; This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q99JD6;Q99JD7;Q99JD8;Q99JD9;Q99JE0;Q99JE1;Q99JE2;Q99JE3", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0000785 chromatin", "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9JJP6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JK00-1", "uniprot_id": [ { "id": "SCN3B_RAT", "url": "https://www.uniprot.org/uniprot/Q9JK00", "type": "external" } ], "mass": 24799.0, "length": 215, "protein_name": "Sodium channel regulatory subunit beta-3", "gene_name": "Scn3b", "organism": "Rat", "refseq_name": "sodium channel regulatory subunit beta-3 precursor", "refseq_ac": [ { "id": "NP_620797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620797", "type": "external" } ], "gene_names_uniprotkb": "Scn3b", "gene_names_refseq": "Scn3b; Scnb3", "protein_names_uniprotkb": "Sodium channel regulatory subunit beta-3", "protein_names_refseq": "sodium channel beta 3 subunit; sodium channel regulatory subunit beta-3 precursor; sodium channel regulatory subunit beta-3; sodium channel subunit beta-3; sodium channel, voltage-gated, type III, beta subunit", "tax_id": 10116, "disease": "Brugada syndrome 7 (Disease Ontology:DOID:0110224); brain edema (Disease Ontology:DOID:4724)", "pathway": " (rno:245956)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10688874;11470829;11922146;14975698;15178439;20675377;24090084;26528804", "class_list": "", "function": "Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:10688874, PubMed:11922146). The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:10688874, PubMed:11470829, PubMed:11922146). Voltage-gated sodium channels regulatory subunit that modulates channel gating kinetics (PubMed:10688874, PubMed:11922146). Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation and increasing the fraction of channels operating in the fast gating mode (PubMed:10688874, PubMed:11922146). Also able to induce unique persistent SCN2A/Nav1.2-mediated sodium currents (PubMed:11922146). Could modulate the activity of SCN10A/Nav1.8 (PubMed:14975698, PubMed:15178439)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The presences of Nav1.1, Nav1.6, Navbeta1 and Navbeta3 mRNA and their reduced levels in rat SAN during aging., [RefSeq, PubMed]; The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 3, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 9, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019871 sodium channel inhibitor activity;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030018 Z disc;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization;GO:0007399 nervous system development;GO:0072659 protein localization to plasma membrane;GO:0051899 membrane depolarization;GO:0086010 membrane depolarization during action potential", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9JK00-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKF0-1", "uniprot_id": [ { "id": "TR123_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKF0", "type": "external" } ], "mass": 38164.0, "length": 333, "protein_name": "Taste receptor type 2 member 123", "gene_name": "Tas2r123", "organism": "Rat", "refseq_name": "taste receptor type 2 member 123", "refseq_ac": [ { "id": "NP_775458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775458", "type": "external" } ], "gene_names_uniprotkb": "Tas2r123; Tas2r14; Tas2r23; Tas2r2", "gene_names_refseq": "Tas2r123; Tas2r14", "protein_names_uniprotkb": "Taste receptor type 2 member 123; T2R123; T2R23; T2R2; Taste receptor type 2 member 23; Taste receptor type 2 member 2", "protein_names_refseq": "T2R123; T2R23; T2R2; taste receptor rT2R2; taste receptor type 2 member 123; taste receptor type 2 member 23; taste receptor type 2 member 2; taste receptor, type 2, member 14", "tax_id": 10116, "disease": "", "pathway": " (rno:287003)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10761934;10761935;11696554;11854532;12139982;12581520", "class_list": "", "function": "Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9JKF0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKF8-1", "uniprot_id": [ { "id": "RASD1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKF8", "type": "external" } ], "mass": 31714.0, "length": 280, "protein_name": "Dexamethasone-induced Ras-related protein 1", "gene_name": "Rasd1", "organism": "Rat", "refseq_name": "dexamethasone-induced Ras-related protein 1", "refseq_ac": [ { "id": "NP_001257883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257883", "type": "external" } ], "gene_names_uniprotkb": "Rasd1; Dexras1", "gene_names_refseq": "Rasd1", "protein_names_uniprotkb": "Dexamethasone-induced Ras-related protein 1", "protein_names_refseq": "DEXRAS1 (Dexras1); RAS, dexamethasone-induced 1; dexamethasone-induced Ras-related protein 1", "tax_id": 10116, "disease": "", "pathway": " (rno:64455)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11086993;17768032;18219571;18922798;24548484;26739966;26785766;28835591;36230939", "class_list": "", "function": "Dexras1 Induces Dysdifferentiation of Oligodendrocytes and Myelin Injury by Inhibiting the cAMP-CREB Pathway after Subarachnoid Hemorrhage. Erratum:[Cells. 2024 Nov 29;13(23):1975. doi: 10.3390/cells13231975. PMID: 39682783] Publication Status: Online-Only, [RefSeq, PubMed]; Dexras1 functions as a suppressor of FE65-APP-mediated transcription, and FE65 tyrosine 547 phosphorylation enhances FE65-APP-mediated transcription, at least in part, by modulating the interaction between FE65 and Dexras1, [RefSeq, PubMed]; Dexras1 is involved in various pathological conditions including nerve regeneration, neuron loss or survival and even pain processes via regulating nNOS activity or through the downstream targets of Dexras1., [RefSeq, PubMed]; RASD1 is downregulated by calycosin in cerebral ischemia/reperfusion injury and provides a protective effect., [RefSeq, PubMed]; Rasd1 is an estrogen-responsive immediate early gene and modulates E2 induction of at least several late genes in anterior pituitary cells., [RefSeq, PubMed]; Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65., [UniProtKB]; The Dexras1 protein is expressed predominantly in the dorsomedial part of thesuprachiasmatic nucleus and the light pulse has only a limited effect on its expression, [RefSeq, PubMed]; Transient high expression of Dexras1 which localized in apoptotic neurons and pathological oligodendrocytes after spinal cord transection., [RefSeq, PubMed]; Two mechanisms of Rasd1 induction in the hypothalamus, were identified. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KLL2", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0007165 signal transduction;GO:0045892 negative regulation of DNA-templated transcription;GO:0007263 nitric oxide mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9JKF8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKT5-1", "uniprot_id": [ { "id": "TR105_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKT5", "type": "external" } ], "mass": 35149.0, "length": 309, "protein_name": "Taste receptor type 2 member 105", "gene_name": "Tas2r105", "organism": "Rat", "refseq_name": "taste receptor type 2 member 105", "refseq_ac": [ { "id": "NP_076489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076489", "type": "external" } ], "gene_names_uniprotkb": "Tas2r105; Tas2r9", "gene_names_refseq": "T2R9; Tas2r105", "protein_names_uniprotkb": "Taste receptor type 2 member 105; T2R105; T2R9; Taste receptor type 2 member 9", "protein_names_refseq": "T2R105; taste receptor T2R9; taste receptor type 2 member 105; taste receptor type 2 member 9", "tax_id": 10116, "disease": "", "pathway": " (rno:78985); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10761934;10761935;11696554;11854532;12139982;12379855;12581520", "class_list": "", "function": "Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9JKT5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JKW1-1", "uniprot_id": [ { "id": "TIM22_RAT", "url": "https://www.uniprot.org/uniprot/Q9JKW1", "type": "external" } ], "mass": 19918.0, "length": 192, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim22", "gene_name": "Timm22", "organism": "Rat", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim22", "refseq_ac": [ { "id": "NP_116007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116007", "type": "external" } ], "gene_names_uniprotkb": "Timm22; Tim22", "gene_names_refseq": "Timm22", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim22", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim22; translocase of inner mitochondrial membrane 22 homolog", "tax_id": 10116, "disease": "combined oxidative phosphorylation deficiency 43 (Disease Ontology:DOID:0112116); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (rno:79463)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10611480", "class_list": "", "function": "Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity;GO:0030943 mitochondrion targeting sequence binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9JKW1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9JM15-1", "uniprot_id": [ { "id": "S38A1_RAT", "url": "https://www.uniprot.org/uniprot/Q9JM15", "type": "external" } ], "mass": 53846.0, "length": 485, "protein_name": "Sodium-coupled neutral amino acid symporter 1", "gene_name": "Slc38a1", "organism": "Rat", "refseq_name": "sodium-coupled neutral amino acid symporter 1", "refseq_ac": [ { "id": "NP_620187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620187", "type": "external" } ], "gene_names_uniprotkb": "Slc38a1; Ata1; Glnt; Sa2; Sat1; Snat1", "gene_names_refseq": "Ata1; GlnT; Sat1; Slc38a1; Snat1", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid symporter 1; Amino acid transporter A1; Glutamine transporter; N-system amino acid transporter 2; Solute carrier family 38 member 1; System A amino acid transporter 1; System A transporter 2; System N amino acid transporter 1; rATA1", "protein_names_refseq": "N-system amino acid transporter 2; amino acid transporter A1; amino acid transporter system A1; contains 11 putative transmembrane domains; glutamine transporter; rATA1; sodium-coupled neutral amino acid symporter 1; sodium-coupled neutral amino acid transporter 1; system A amino acid transporter 1; system A transporter 2; system N amino acid transporter 1", "tax_id": 10116, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:170567); (R-RNO-210455); (R-RNO-352230)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10660562;11692272;11756489;12684517;12855186;15054072;16023720;17323379;20602128;22673903;25957749;26590355", "class_list": "", "function": "Distribution of SNAT1 in central nervous system neurons and characterization of its transport properties, [RefSeq, PubMed]; Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming, [RefSeq, PubMed]; Overexpression of X-box binding protein-1 led to a marked increase in luciferase activity in P19 cells transfected with the Slc38a1 reporter plasmid. These results suggest that theanine accelerates cellular proliferation and subsequent neuronal specification through a mechanism relevant to upregulation of Slc38a1 gene in undifferentiated neural progenitor cells, [RefSeq, PubMed]; Oxidative stress increases SNAT1 expression and stimulates cysteine uptake in rat cardiomyocytes., [RefSeq, PubMed]; Symporter that cotransports short-chain neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10660562, PubMed:11692272, PubMed:11756489, PubMed:12684517). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:11692272, PubMed:11756489, PubMed:12684517). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (PubMed:10660562, PubMed:11756489). May also contributes to amino acid transport in placental trophoblast (By similarity). Regulates synaptic plasticity (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0005298 proline:sodium symporter activity;GO:0015186 L-glutamine transmembrane transporter activity;GO:0005283 amino acid:sodium symporter activity;GO:0015375 glycine:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0048167 regulation of synaptic plasticity;GO:0007565 female pregnancy;GO:0006868 glutamine transport;GO:0015804 neutral amino acid transport;GO:1903803 L-glutamine import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9JM15-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9P290-1", "uniprot_id": [ { "id": "S22AH_RAT", "url": "https://www.uniprot.org/uniprot/Q9P290", "type": "external" } ], "mass": 55801.0, "length": 520, "protein_name": "Solute carrier family 22 member 17", "gene_name": "Slc22a17", "organism": "Rat", "refseq_name": "solute carrier family 22 member 17 isoform X1", "refseq_ac": [ { "id": "XP_006252027", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006252027", "type": "external" } ], "gene_names_uniprotkb": "Slc22a17; Boct; Boit", "gene_names_refseq": "24p3R; Boct; Slc22a17; rBOCT", "protein_names_uniprotkb": "Solute carrier family 22 member 17; 24p3 receptor; 24p3R; Brain-type organic cation transporter; Lipocalin-2 receptor", "protein_names_refseq": "solute carrier family 22 member 17 isoform X1", "tax_id": 10116, "disease": "", "pathway": " (rno:305886); (R-RNO-917937)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4KLP1", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005774 vacuolar membrane;GO:0031090 organelle membrane;GO:0016020 membrane", "go_biological_process": "GO:0015891 siderophore transport;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9P290-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUL0-1", "uniprot_id": [ { "id": "PR3C1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QUL0", "type": "external" } ], "mass": 24575.0, "length": 211, "protein_name": "Prolactin-3C1", "gene_name": "Prl3c1", "organism": "Rat", "refseq_name": "prolactin-3C1 precursor", "refseq_ac": [ { "id": "NP_112606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112606", "type": "external" } ], "gene_names_uniprotkb": "Prl3c1; Prlpi; Prlpj", "gene_names_refseq": "Prl3c1; Prlpi; Prlpj", "protein_names_uniprotkb": "Prolactin-3C1; Decidualin; PLP-I; PLP-J; PRL-like protein I; PRL-like protein J; Placental prolactin-like protein J; Prolactin-like protein I", "protein_names_refseq": "PLP-I; PLP-J; PRL-like protein I; PRL-like protein J; decidualin; placental prolactin-like protein J; prolactin-3C1 precursor; prolactin-3C1; prolactin-like protein 1; prolactin-like protein I; prolactin-like protein J", "tax_id": 10116, "disease": "hyperandrogenism (Disease Ontology:DOID:11613)", "pathway": " (rno:58937)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10471365;10537137;10542329;10856884;18467328", "class_list": "", "function": "The restricted expression of PLP-J and its specific interactions with uterine stromal cells and endothelial cells suggests that it acts locally and regulates decidual cell development and the endometrial vasculature., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9R0S7", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9QUL0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QUS1-1", "uniprot_id": [ { "id": "NR1I3_RAT", "url": "https://www.uniprot.org/uniprot/Q9QUS1", "type": "external" } ], "mass": 40923.0, "length": 358, "protein_name": "Nuclear receptor subfamily 1 group I member 3", "gene_name": "Nr1i3", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 1 group I member 3 isoform 1", "refseq_ac": [ { "id": "NP_075230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075230", "type": "external" } ], "gene_names_uniprotkb": "Nr1i3; Car", "gene_names_refseq": "CAR; Nr1i3", "protein_names_uniprotkb": "Nuclear receptor subfamily 1 group I member 3; CAR; Constitutive androstane receptor", "protein_names_refseq": "constitutive androstane receptor; nuclear receptor constitutive active receptor; nuclear receptor subfamily 1 group I member 3 isoform 1; strain Fischer nuclear receptor (CAR)", "tax_id": 10116, "disease": "", "pathway": " (rno:65035); (R-RNO-383280)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "11160864;15953603;26053941;27665777;29204052;34264181", "class_list": "", "function": "Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity)., [UniProtKB]; CAR expressed in the hepatic preneoplastic lesions of rats is resistant to nuclear translocation and transactivation of the phenobarbital(PB) responsive enhancer module upon PB treatment., [RefSeq, PubMed]; Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)., [RefSeq, PubMed]; Metabolism of methiocarb and carbaryl does not alter CAR activity., [RefSeq, PubMed]; Nuclear expression virtually disappeared in the late stage of cholestatic injury, after an initial increase, [RefSeq, PubMed]; Serum 5-HT regulates the expression of Mrp2 and P-gp, and the underlying mechanism may be related to the altered expression of the nuclear receptor constitutive androstane receptor., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QUS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QWM1-1", "uniprot_id": [ { "id": "NR5A2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QWM1", "type": "external" } ], "mass": 63904.0, "length": 560, "protein_name": "Nuclear receptor subfamily 5 group A member 2", "gene_name": "Nr5a2", "organism": "Rat", "refseq_name": "nuclear receptor subfamily 5 group A member 2", "refseq_ac": [ { "id": "NP_068510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068510", "type": "external" } ], "gene_names_uniprotkb": "Nr5a2", "gene_names_refseq": "Ftf; Lrh-1; Nr5a2", "protein_names_uniprotkb": "Nuclear receptor subfamily 5 group A member 2; FTZ-F1 beta; LRH-1; Liver receptor homolog 1", "protein_names_refseq": "FTZ-F1 beta2 protein; fetoprotein transcription factor; liver receptor homolog 1; nuclear receptor subfamily 5 group A member 2", "tax_id": 10116, "disease": "colon cancer (Disease Ontology:DOID:219)", "pathway": " (rno:60349); (R-RNO-383280); (R-RNO-4090294); (R-RNO-9018519)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "12672674;12865342;14736734;36857632", "class_list": "", "function": "Data indicate that granulosa cells of small and preovulatory follicles express both SF-1 and FTF/LRH-1 and that each orphan receptor may regulate target gene expression in these cells, [RefSeq, PubMed]; Evidence provided that LRH-1 plays an important role in the regulation of aromatase expression in Leydig cells, [RefSeq, PubMed]; Liver receptor homologue 1 (LRH-1) is a member of the nuclear receptor superfamily originally found in liver cells. LRH-1 participates in regulation of cholesterol metabolism and bile acid synthesis. Recent studies have shown that LRH-1 is even more highl, [RefSeq, PubMed]; Orphan nuclear receptor that binds DNA as a monomer to the 5'-TCAAGGCCA-3' sequence and controls expression of target genes: regulates key biological processes, such as early embryonic development, cholesterol and bile acid synthesis pathways, as well as liver and pancreas morphogenesis. Ligand-binding causes conformational change which causes recruitment of coactivators, promoting target gene activation. The specific ligand is unknown, but specific phospholipids, such as phosphatidylethanolamine, phosphatidylserine, dilauroyl phosphatidylcholine and diundecanoyl phosphatidylcholine can act as ligand in vitro. Acts as a pioneer transcription factor, which unwraps target DNA from histones and elicits local opening of closed chromatin (By similarity). Plays a central role during preimplantation stages of embryonic development. Plays a minor role in zygotic genome activation (ZGA) by regulating a small set of two-cell stage genes. Plays a major role in morula development (2-16 cells embryos) by acting as a master regulator at the 8-cell stage, controlling expression of lineage-specifying transcription factors and genes involved in mitosis, telomere maintenance and DNA repair. Zygotic NR5A2 binds to both closed and open chromatin with other transcription factors, often at SINE B1/Alu repeats DNA elements, promoting chromatin accessibility at nearby regulatory regions (By similarity). Also involved in the epiblast stage of development and embryonic stem cell pluripotency, by promoting expression of POU5F1/OCT4 (By similarity). Regulates other processes later in development, such as formation of connective tissue in lower jaw and middle ear, neural stem cell differentiation, ovarian follicle development and Sertoli cell differentiation. Involved in exocrine pancreas development and acinar cell differentiation (By similarity). Acts as an essential transcriptional regulator of lipid metabolism. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. Also acts as a negative regulator of inflammation in different organs, such as, liver and pancreas (By similarity). Protects against intestinal inflammation via its ability to regulate glucocorticoid production (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity). Acts as a regulator of immunity by promoting lymphocyte T-cell development, proliferation and effector functions. Also involved in resolution of endoplasmic reticulum stress in the liver (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; TGF-beta1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in rat Leydig cellsdagger., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9QWM0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0001545 primary ovarian follicle growth;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QWM1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QXQ5-1", "uniprot_id": [ { "id": "WNT4_RAT", "url": "https://www.uniprot.org/uniprot/Q9QXQ5", "type": "external" } ], "mass": 39044.0, "length": 351, "protein_name": "Protein Wnt-4", "gene_name": "Wnt4", "organism": "Rat", "refseq_name": "protein Wnt-4 precursor", "refseq_ac": [ { "id": "NP_445854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445854", "type": "external" } ], "gene_names_uniprotkb": "Wnt4; Wnt-4", "gene_names_refseq": "Wnt4", "protein_names_uniprotkb": "Protein Wnt-4", "protein_names_refseq": "protein Wnt-4 precursor; protein Wnt-4; wingless-related MMTV integration site 4; wingless-type MMTV integration site family, member 4", "tax_id": 10116, "disease": "Mullerian aplasia and hyperandrogenism (Disease Ontology:DOID:0111526); endometrial carcinoma (Disease Ontology:DOID:2871); acute kidney failure (Disease Ontology:DOID:3021)", "pathway": " (rno:84426); (R-RNO-3238698); (R-RNO-4086400)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "29429512;29921370;30002385", "class_list": "", "function": "Compared with the saline Hepatocellular carcinoma (HCC)-group, transplantation with CD34+ human hematopoietic stem cells produced a further increase in the levels of wnt4 (+19.4%) and p53 gene expression (+53%), a 2-fold increase in the percentage of cancer progenitor cells and increased HCC pathology grading, [RefSeq, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors. Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development. Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary. Required for normal lung development and for normal patterning of trachael cartilage rings., [UniProtKB, UniProtKB]; Study of cisplatin-induced acute kidney injury (AKI) model in rats and clinical study of contrast agent induced AKI is the first to demonstrate that increased expression of renal and urinary Wnt4 can be detected earlier than serum creatinine after drug-induced AKI suggesting that urinary Wnt4 can potentially serve as a noninvasive biomarker for monitoring patients with tubular injury. Publication Status: Online-Only, [RefSeq, PubMed]; This suggests that soybean isoflavones could delay the process of renal interstitial fibrosis in DN rats by decreasing the expression of Wnt4, beta-catenin and TGF-beta1 in the renal interstitium, thus demonstrating that soybean isoflavones plus losartan have the best protective effects against diabetes-induced renal fibrosis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0003714 transcription corepressor activity;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0045836 positive regulation of meiotic nuclear division;GO:0072006 nephron development;GO:0060993 kidney morphogenesis;GO:0060126 somatotropin secreting cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9QXQ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYK2-1", "uniprot_id": [ { "id": "PRGC1_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYK2", "type": "external" } ], "mass": 90622.0, "length": 796, "protein_name": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "gene_name": "Ppargc1a", "organism": "Rat", "refseq_name": "peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "refseq_ac": [ { "id": "NP_112637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112637", "type": "external" } ], "gene_names_uniprotkb": "Ppargc1a; Pgc1a; Pgc1; Ppargc1", "gene_names_refseq": "LRPGC1; PGC-1v; PGCvf-1; PGCvf1; PGCvf; Ppargc1a; Ppargc1", "protein_names_uniprotkb": "Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha", "protein_names_refseq": "PGC-1-alpha; PGC-1alpha; PPAR gamma coactivator 1alpha variant form-1; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ppargc1a-vf1; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha", "tax_id": 10116, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); cardiomyopathy (Disease Ontology:DOID:0050700); renal fibrosis (Disease Ontology:DOID:0050855); colitis (Disease Ontology:DOID:0060180); abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); amblyopia (Disease Ontology:DOID:10376); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); age related macular degeneration (Disease Ontology:DOID:10871); amnestic disorder (Disease Ontology:DOID:10914); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); prediabetes syndrome (Disease Ontology:DOID:11716); nephrotic syndrome (Disease Ontology:DOID:1184); morbid obesity (Disease Ontology:DOID:11981); primary biliary cholangitis (Disease Ontology:DOID:12236); Huntington's disease (Disease Ontology:DOID:12858); cardiovascular system disease (Disease Ontology:DOID:1287); dilated cardiomyopathy (Disease Ontology:DOID:12930); Parkinson's disease (Disease Ontology:DOID:14330); malignant fibrous histiocytoma (Disease Ontology:DOID:1907); melanoma (Disease Ontology:DOID:1909); kidney cancer (Disease Ontology:DOID:263); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); placental insufficiency (Disease Ontology:DOID:3891); hyperglycemia (Disease Ontology:DOID:4195); macular degeneration (Disease Ontology:DOID:4448); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperthyroidism (Disease Ontology:DOID:7998); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:83516); (R-RNO-9841922)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10913342;11108270;11875072;12072378;12107181;19103600;37085803;37526811;37962014;38139395;38677116", "class_list": "", "function": "Cooling of male rat skeletal muscle during endurance-like contraction attenuates contraction-induced PGC-1alpha mRNA expression., [RefSeq, PubMed]; HIV-1 Tat Induces Dysregulation of PGC1-Alpha and Sirtuin 3 Expression in Neurons: The Role of Mitochondrial Biogenesis in HIV-Associated Neurocognitive Disorder (HAND). Publication Status: Online-Only, [RefSeq, PubMed]; Increased PGC-1 expression and subsequent hepatic glucose production contribute to the insulin resistance observed in the intrauterine growth retardation juvenile rat, [RefSeq, PubMed]; PGC-1alpha Inhibits Schwann Cell Dedifferentiation and Delays Peripheral Nerve Degeneration by Targeting PON1., [RefSeq, PubMed]; Peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1 recruitment regulates PPAR subtype specificity., [RefSeq, PubMed]; Results show that CREB and HNF4alpha bind the CPT promoter, that PGC-1 is involved in liver carnitine palmitoyltransferase I (CPT) gene activation by cylic AMP, and that PGC-1 acts to coordinate the process of metabolic adaptation in the liver., [RefSeq, PubMed]; The mechanism by which miR-494-3p regulates PGC1-alpha-mediated inhibition of mitophagy in cardiomyocytes and alleviation of myocardial ischemia-reperfusion injury. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (By similarity). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1alpha/ERRalpha axis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 37, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0031625 ubiquitin protein ligase binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043025 neuronal cell body;GO:0016605 PML body", "go_biological_process": "GO:2000272 negative regulation of signaling receptor activity;GO:1990910 response to hypobaric hypoxia;GO:0002931 response to ischemia;GO:0006351 DNA-templated transcription;GO:0007584 response to nutrient", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9QYK2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QYW3-1", "uniprot_id": [ { "id": "PHOCN_RAT", "url": "https://www.uniprot.org/uniprot/Q9QYW3", "type": "external" } ], "mass": 26032.0, "length": 225, "protein_name": "MOB-like protein phocein", "gene_name": "Mob4", "organism": "Rat", "refseq_name": "MOB-like protein phocein", "refseq_ac": [ { "id": "NP_598212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598212", "type": "external" } ], "gene_names_uniprotkb": "Mob4; Mob3; Mobkl1; Phocn; Prei3", "gene_names_refseq": "Mob4; Mobkl1; Mobkl3; Phocn; Prei3; phocein", "protein_names_uniprotkb": "MOB-like protein phocein; Class II mMOB1; Mob1 homolog 3; Mob3; Mps one binder kinase activator-like 3; Phocein; Preimplantation protein 3", "protein_names_refseq": "MOB-like protein phocein; MOB1, Mps One Binder kinase activator-like 3; class II mMOB1; mob1 homolog 3; mob3; mps one binder kinase activator-like 3; phocein, Mob-like protein; preimplantation protein 3", "tax_id": 10116, "disease": "", "pathway": " (rno:171050)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11251078;11872741;18466332;23015759", "class_list": "", "function": "Interaction with nucleoside-diphosphate kinase, eps15, and dynamin I (phocein), [RefSeq, PubMed]; Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Zinedin is primarily expressed in neurons of the hippocampus, cerebral cortex, olfactory bulb and caudate putamen nucleus. AND displays a polarized distribution in the somato-dendritic compartment of neurons and is enriched in dendritic spines., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0043025 neuronal cell body;GO:0043197 dendritic spine", "go_biological_process": "GO:0006900 vesicle budding from membrane;GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9QYW3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9QZQ4-1", "uniprot_id": [ { "id": "UTS2_RAT", "url": "https://www.uniprot.org/uniprot/Q9QZQ4", "type": "external" } ], "mass": 13614.0, "length": 123, "protein_name": "Urotensin-2", "gene_name": "Uts2", "organism": "Rat", "refseq_name": "urotensin-2 precursor", "refseq_ac": [ { "id": "NP_062033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062033", "type": "external" } ], "gene_names_uniprotkb": "Uts2", "gene_names_refseq": "U-II; UII; Ucn2; Uts2", "protein_names_uniprotkb": "Urotensin-2; U-II; UII; Urotensin II", "protein_names_refseq": "urocortin 2; urotensin II; urotensin-2 precursor", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); gestational diabetes (Disease Ontology:DOID:11714); endomyocardial fibrosis (Disease Ontology:DOID:12932); asthma (Disease Ontology:DOID:2841); carotid artery disease (Disease Ontology:DOID:3407); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (rno:29180); (R-RNO-375276); (R-RNO-416476)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10486557;27448985;27613164;28656205;29257277;31473519", "class_list": "", "function": "Aldosterone and its receptors were expressed on tunica adventitia. Urotensin II promoted ALD protein secretion from cells in a dose and timedependent manner., [RefSeq, PubMed]; Highly potent vasoconstrictor., [UniProtKB]; IRF3 expression and activation depend on the signal transduction of the the urotensin II/urotensin receptor (UII/UT) system, and play important roles in UII/UT-mediated immune inflammatory injury in the liver, [RefSeq, PubMed]; Results suggest that GRK5 may be involved in a UII-mediated hypertrophic response via activation of NF-kappaB and HDAC5 at least in part by ERK1/2 and GSK3alpha/beta-independent pathways., [RefSeq, PubMed]; There is an increase of Ucn2 mRNA levels in the adrenal medulla and spleen induced by immobilization stress., [RefSeq, PubMed]; These results suggest that urotensin II induces cardiomyocyte hypertrophy through the cAMP-dependent protein kinase A -mediated upregulation of phospholamban phosphorylation at Ser16, which provides a new experimental foundation for the prevention and/or treatment of cardiac hypertrophy., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0045777 positive regulation of blood pressure;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9QZQ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R0S5-1", "uniprot_id": [ { "id": "YLAT1_RAT", "url": "https://www.uniprot.org/uniprot/Q9R0S5", "type": "external" } ], "mass": 55641.0, "length": 512, "protein_name": "Y+L amino acid transporter 1", "gene_name": "Slc7a7", "organism": "Rat", "refseq_name": "Y+L amino acid transporter 1", "refseq_ac": [ { "id": "NP_112631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112631", "type": "external" } ], "gene_names_uniprotkb": "Slc7a7", "gene_names_refseq": "Slc7a7; y+LAT1", "protein_names_uniprotkb": "Y+L amino acid transporter 1; Solute carrier family 7 member 7; Y+LAT1; y(+)L-type amino acid transporter 1; y+LAT-1", "protein_names_refseq": "Y+L amino acid transporter 1; solute carrier family 7 (amino acid transporter light chain, y+L system), member 7; solute carrier family 7 (cationic amino acid transporter, y+ system), member 7; y(+)L-type amino acid transporter 1; y+LAT-1", "tax_id": 10116, "disease": "lysinuric protein intolerance (Disease Ontology:DOID:0060439)", "pathway": " (rno:83509); (R-RNO-210991); (R-RNO-352230)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10777485;19388351;22673903;9878049", "class_list": "", "function": "Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:10777485). Also mediates L-arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (By similarity). The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (PubMed:10777485). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (PubMed:10777485)., [UniProtKB, UniProtKB, PubMed]; LAT1 may be transiently upregulated as part of the tissue-repair process after traumatic contusion injury in the spinal cord, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9QZ66", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015174 basic amino acid transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:1902495 transmembrane transporter complex;GO:0016020 membrane", "go_biological_process": "GO:0015820 L-leucine transport;GO:0003333 amino acid transmembrane transport;GO:1903826 L-arginine transmembrane transport;GO:0089718 amino acid import across plasma membrane;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9R0S5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9R154-1", "uniprot_id": [ { "id": "S26A4_RAT", "url": "https://www.uniprot.org/uniprot/Q9R154", "type": "external" } ], "mass": 85715.0, "length": 780, "protein_name": "Pendrin", "gene_name": "Slc26a4", "organism": "Rat", "refseq_name": "pendrin", "refseq_ac": [ { "id": "NP_062087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062087", "type": "external" } ], "gene_names_uniprotkb": "Slc26a4; Pds", "gene_names_refseq": "Pds; Slc26a4", "protein_names_uniprotkb": "Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4", "protein_names_refseq": "Pendred syndrome homolog; pendrin; sodium-independent chloride/iodide transporter; solute carrier family 26 (anion exchanger), member 4", "tax_id": 10116, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Pendred Syndrome (Disease Ontology:DOID:0060744); autosomal recessive nonsyndromic deafness 4 (Disease Ontology:DOID:0110498); goiter (Disease Ontology:DOID:12176)", "pathway": " (rno:29440); (R-RNO-427601)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10449762;11208611;11274445;12107249;26173457;26791486;26932931;34326480;36977894", "class_list": "", "function": "Characterization of pendrin in urinary extracellular vesicles in a rat model of aldosterone excess and in human primary aldosteronism., [RefSeq, PubMed]; Pendrin abundance, subcellular distribution, and function are unaffected by either alphaENaC gene ablation or by increasing ENaC channel activity., [RefSeq, PubMed]; Pendrin is expressed in the adrenal medulla, where it blunts stress-induced catecholamine release. Erratum:[Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E885. doi: 10.1152/ajpendo.zh1-7433-corr.2015. PMID: 26573274], [RefSeq, PubMed]; Sodium-independent transporter of chloride and iodide (PubMed:12107249, PubMed:26791486). Mediates electroneutral chloride-bicarbonate and chloride-formate exchange with 1:1 stoichiometry (PubMed:11208611). Mediates electroneutral iodide-chloride and iodide-bicarbonate exchange (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; These data suggest that pendrin may have an important role in mediating iodide efflux in thyrocytes, especially under conditions of iodide excess., [RefSeq, PubMed]; These studies implicate the involvement of pendrin-facilitated chloride-bicarbonate exchange in the regulation of airway surface liquid volume and suggest the utility of pendrin inhibitors in inflammatory lung diseases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0015111 iodide transmembrane transporter activity;GO:0015108 chloride transmembrane transporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane;GO:0031526 brush border membrane", "go_biological_process": "GO:0032880 regulation of protein localization;GO:0015705 iodide transport;GO:1902476 chloride transmembrane transport;GO:0015698 inorganic anion transport;GO:0006885 regulation of pH", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9R154-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTQ6-1", "uniprot_id": [ { "id": "TRIB3_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTQ6", "type": "external" } ], "mass": 38602.0, "length": 349, "protein_name": "Tribbles homolog 3", "gene_name": "Trib3", "organism": "Rat", "refseq_name": "tribbles homolog 3", "refseq_ac": [ { "id": "NP_653356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653356", "type": "external" } ], "gene_names_uniprotkb": "Trib3; Nipk", "gene_names_refseq": "NIPK; Trib3", "protein_names_uniprotkb": "Tribbles homolog 3; Neuronal cell death-inducible putative kinase; TRB-3", "protein_names_refseq": "Neuronal cell death Inducible Putative Kinase; TRB-3; neuronal cell death-inducible putative kinase; tribbles homolog 3", "tax_id": 10116, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (rno:246273); (R-RNO-1257604); (R-RNO-165158); (R-RNO-199418); (R-RNO-389357); (R-RNO-5218920)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10329375;15469416;28782643;34553361;34906150;38302075", "class_list": "", "function": "Chronic intermittent hypoxia-induced oxidative stress activates TRB3 and phosphorylated JNK to mediate insulin resistance and cell apoptosis in the pancreas., [RefSeq, PubMed]; Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (By similarity). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (By similarity). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (PubMed:15469416). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases (By similarity). Can inhibit APOBEC3A editing of nuclear DNA (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; TRB3 mediates vascular remodeling by activating the MAPK signaling pathway in hypoxic pulmonary hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; TRB3 participated in the global cerebral ischemia and reperfusion injury-induced neuronal apoptosis, [RefSeq, PubMed]; TRIB3-Regulated Akt Signal Pathway Affects Trophoblast Invasion in the Development of Preeclampsia., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5BKD1", "ec_number_list": [], "go_molecular_function": "GO:0055106 ubiquitin-protein transferase regulator activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010506 regulation of autophagy;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9WTQ6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WTW7-1", "uniprot_id": [ { "id": "S23A1_RAT", "url": "https://www.uniprot.org/uniprot/Q9WTW7", "type": "external" } ], "mass": 65263.0, "length": 604, "protein_name": "Solute carrier family 23 member 1", "gene_name": "Slc23a1", "organism": "Rat", "refseq_name": "solute carrier family 23 member 1", "refseq_ac": [ { "id": "NP_059011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059011", "type": "external" } ], "gene_names_uniprotkb": "Slc23a1; Svct1", "gene_names_refseq": "SVCT1; Slc23a1", "protein_names_uniprotkb": "Solute carrier family 23 member 1; Na(+)/L-ascorbic acid transporter 1; Sodium-dependent vitamin C transporter 1", "protein_names_refseq": "Na(+)/L-ascorbic acid transporter 1; sodium-coupled ascorbic acid transporter 1; sodium-dependent vitamin C transporter 1; solute carrier family 23 (ascorbic acid transporter), member 1; solute carrier family 23 (nucleobase transporters), member 1; solute carrier family 23 member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:50621); (R-RNO-196836)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10331392;11834736;21733302;22348976;23708151", "class_list": "", "function": "Glutathione depletion failed to affect ascorbic acid transport, and SVCT1 and SVCT2 expression in hepatoma cells., [RefSeq, PubMed]; In adult rats, when obstructive cholestasis was maintained for 8 weeks, a significant up-regulation of Slc23a2 accompanied by a down-regulation of Slc23a1 was found., [RefSeq, PubMed]; Inhibited by flavonoids, an intestinal transporter for vitamin c, [RefSeq, PubMed]; Metabolic/oxidative stress in the liver induce different responses in the expression of ascorbic acid transporters SVCT1 and SVCT2 in intrahepatic and extrahepatic tissues, which may affect the overall bioavailability and cellular uptake of this vitamin, [RefSeq, PubMed]; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10331392). Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008520 L-ascorbate:sodium symporter activity;GO:0015229 L-ascorbic acid transmembrane transporter activity;GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0015081 sodium ion transmembrane transporter activity;GO:0015143 urate transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015882 L-ascorbic acid transmembrane transport;GO:0070837 dehydroascorbic acid transport;GO:0030324 lung development;GO:0007420 brain development;GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9WTW7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WUW9-1", "uniprot_id": [ { "id": "S1C2A_RAT", "url": "https://www.uniprot.org/uniprot/Q9WUW9", "type": "external" } ], "mass": 34859.0, "length": 296, "protein_name": "Sulfotransferase 1C2A", "gene_name": "Sult1c2a", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Sult1c2a; Sultk2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sulfotransferase 1C2A; 2.8.2.1; ST1C2A; Sulfotransferase K2; rSULT1C2A", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (rno:316153)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10872834", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds (PubMed:10872834). Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol (By similarity) (PubMed:10872834). Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q569D0;Q642G8", "ec_number_list": [ { "id": "2.8.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.1", "type": "external" }, { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.2", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0004062 aryl sulfotransferase activity;GO:0051922 cholesterol sulfotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005764 lysosome", "go_biological_process": "GO:0051923 sulfation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WUW9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WV97-1", "uniprot_id": [ { "id": "TIM9_RAT", "url": "https://www.uniprot.org/uniprot/Q9WV97", "type": "external" } ], "mass": 10376.0, "length": 89, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim9", "gene_name": "Timm9", "organism": "Rat", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim9", "refseq_ac": [ { "id": "NP_001263358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263358", "type": "external" } ], "gene_names_uniprotkb": "Timm9; Tim9a; Tim9; Timm9a", "gene_names_refseq": "Tim9a; Tim9; Timm9a; Timm9", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim9", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim9; translocase of inner mitochondrial membrane 9 homolog", "tax_id": 10116, "disease": "", "pathway": " (rno:171139)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051087 protein-folding chaperone binding;GO:0032977 membrane insertase activity;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9WV97-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVA1-1", "uniprot_id": [ { "id": "TIM8A_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVA1", "type": "external" } ], "mass": 11042.0, "length": 97, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim8 A", "gene_name": "Timm8a", "organism": "Rat", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim8 A", "refseq_ac": [ { "id": "NP_445822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445822", "type": "external" } ], "gene_names_uniprotkb": "Timm8a; Ddp1; Tim8a", "gene_names_refseq": "DDP; Ddp1; Timm8a1; Timm8a", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim8 A; Deafness dystonia protein 1 homolog", "protein_names_refseq": "deafness dystonia protein 1 homolog; mitochondrial import inner membrane translocase subunit Tim8 A; translocase of inner mitochondrial membrane 8 homolog A1; translocase of inner mitochondrial membrane 8 homolog a", "tax_id": 10116, "disease": "deafness-dystonia-optic neuronopathy syndrome (Disease Ontology:DOID:0050757); dystonia (Disease Ontology:DOID:543)", "pathway": " (rno:84383)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10611480", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane;GO:0006626 protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9WVA1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9WVR7-1", "uniprot_id": [ { "id": "PPM1F_RAT", "url": "https://www.uniprot.org/uniprot/Q9WVR7", "type": "external" } ], "mass": 49165.0, "length": 450, "protein_name": "Protein phosphatase 1F", "gene_name": "Ppm1f", "organism": "Rat", "refseq_name": "protein phosphatase 1F", "refseq_ac": [ { "id": "NP_786931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786931", "type": "external" } ], "gene_names_uniprotkb": "Ppm1f; Popx2", "gene_names_refseq": "CaMKPase; Ppm1f", "protein_names_uniprotkb": "Protein phosphatase 1F; 3.1.3.16; Ca(2+)/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CaMKPase; Partner of PIX 2", "protein_names_refseq": "CaM-kinase phosphatase; ca(2+)/calmodulin-dependent protein kinase phosphatase; calcium/calmodulin-dependent protein kinase phosphatase; partner of PIX 2; protein phosphatase 1F (PP2C domain containing); protein phosphatase 1F", "tax_id": 10116, "disease": "", "pathway": " (rno:287931)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10348902;23991411", "class_list": "", "function": "Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis., [UniProtKB]; The truncated CaMKP-N may play an important physiological role in neuronal cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" } ], "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9WVR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0R7-1", "uniprot_id": [ { "id": "TS1R2_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0R7", "type": "external" } ], "mass": 95800.0, "length": 843, "protein_name": "Taste receptor type 1 member 2", "gene_name": "Tas1r2", "organism": "Rat", "refseq_name": "taste receptor type 1 member 2 precursor", "refseq_ac": [ { "id": "NP_001258195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258195", "type": "external" } ], "gene_names_uniprotkb": "Tas1r2; Gpr71; T1r2; Tr2", "gene_names_refseq": "Aldh4a1; Gpr71; T1r2; Tas1r2; Tr2", "protein_names_uniprotkb": "Taste receptor type 1 member 2; G protein-coupled receptor 71; Sweet taste receptor T1R2", "protein_names_refseq": "G protein-coupled receptor 71; aldehyde dehydrogenase 4 family, member A1; sweet taste receptor T1R2; taste receptor TR2; taste receptor type 1 member 2 precursor; taste receptor, type 1, member 2", "tax_id": 10116, "disease": "", "pathway": " (rno:100270683); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10052456;23636420;28782537;31655082", "class_list": "", "function": "A subset of synaptogyrin-1-immunoreactive taste cells also expressed phospholipase Cbeta2, gustducin, or sweet taste receptor (T1R2)., [RefSeq, PubMed]; Maternal high-fat diet during gestation and lactation increases conditioned aversion threshold for sucrose and alters sweet taste receptors expression in taste buds in rat offspring., [RefSeq, PubMed]; Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners., [UniProtKB]; Sweet taste molecules of T1R2, T1R3, alpha-gustducin and TRPM5 in ileum were dramatically higher than those in duodenum (P<0.01 for each)., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033041 sweet taste receptor activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:1903767 sweet taste receptor complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex;GO:0038037 G protein-coupled receptor dimeric complex", "go_biological_process": "GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste;GO:0032467 positive regulation of cytokinesis;GO:0050916 sensory perception of sweet taste", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9Z0R7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0R8-1", "uniprot_id": [ { "id": "TS1R1_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0R8", "type": "external" } ], "mass": 93497.0, "length": 840, "protein_name": "Taste receptor type 1 member 1", "gene_name": "Tas1r1", "organism": "Rat", "refseq_name": "taste receptor type 1 member 1 precursor", "refseq_ac": [ { "id": "NP_445757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445757", "type": "external" } ], "gene_names_uniprotkb": "Tas1r1; Gpr70; T1r1; Tr1", "gene_names_refseq": "Gpr70; Tas1r1", "protein_names_uniprotkb": "Taste receptor type 1 member 1; G protein-coupled receptor 70", "protein_names_refseq": "G-protein coupled receptor 70; taste receptor type 1 member 1 precursor; taste receptor, type 1, member 1", "tax_id": 10116, "disease": "", "pathway": " (rno:29407); (R-RNO-418594); (R-RNO-420499); (R-RNO-9717207)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "10052456", "class_list": "", "function": "Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0050917 sensory perception of umami taste", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9Z0R8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0V5-1", "uniprot_id": [ { "id": "PRDX4_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0V5", "type": "external" } ], "mass": 31007.0, "length": 273, "protein_name": "Peroxiredoxin-4", "gene_name": "Prdx4", "organism": "Rat", "refseq_name": "peroxiredoxin-4 precursor", "refseq_ac": [ { "id": "NP_445964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_445964", "type": "external" } ], "gene_names_uniprotkb": "Prdx4; Rno2CysPrx04", "gene_names_refseq": "Prdx4", "protein_names_uniprotkb": "Peroxiredoxin-4; 1.11.1.24; Antioxidant enzyme AOE372; Peroxiredoxin IV; Prx-IV; Thioredoxin peroxidase AO372; Thioredoxin-dependent peroxide reductase A0372; Thioredoxin-dependent peroxiredoxin 4", "protein_names_refseq": "antioxidant enzyme AOE372; peroxiredoxin IV; peroxiredoxin-4 precursor; prx-IV; thioredoxin peroxidase AO372; thioredoxin-dependent peroxide reductase A0372; thioredoxin-dependent peroxiredoxin 4", "tax_id": 10116, "disease": "", "pathway": " (rno:85274); (R-RNO-6798695)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10025941;10731722;21454685;28391163;28391978;29804005", "class_list": "", "function": "In the rough endoplasmic reticulum, Prx-4 interacts with and is located with STIM1 in liver microsomes., [RefSeq, PubMed]; Our data suggested that reactive oxygen species, at least in part, play a role in cancer metastatic pain development and persistency which can be attenuated by the adminstration of recombinant PTD-Cu/Zn SOD via the peroxiredoxin 4 modulation from oxidative stress., [RefSeq, PubMed]; The regulatory effects of PRDX4 on IL-1beta-induced chondrocyte apoptosis., [RefSeq, PubMed]; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.6.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" } ], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0008379 thioredoxin peroxidase activity;GO:0140313 molecular sequestering activity;GO:0140824 thioredoxin-dependent peroxiredoxin activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005790 smooth endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:2000255 negative regulation of male germ cell proliferation;GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis;GO:0030198 extracellular matrix organization;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9Z0V5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z0Z5-1", "uniprot_id": [ { "id": "S13A3_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z0Z5", "type": "external" } ], "mass": 66099.0, "length": 600, "protein_name": "Na(+)/dicarboxylate cotransporter 3", "gene_name": "Slc13a3", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Slc13a3; Nadc3; Sdct2", "gene_names_refseq": "", "protein_names_uniprotkb": "Na(+)/dicarboxylate cotransporter 3; Na(+)-coupled carboxylate transporter 3; NaC3; NaDC-3; SDCT2; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 member 3; rNaDC3", "protein_names_refseq": "", "tax_id": 10116, "disease": "", "pathway": " (R-RNO-9955298)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10207168;10794676;10992006;12177002;9920886", "class_list": "", "function": "High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed:10207168, PubMed:10794676, PubMed:10992006, PubMed:12177002, PubMed:9920886). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:10207168, PubMed:10992006, PubMed:9920886). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed:10207168). Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0015137 citrate transmembrane transporter activity;GO:0015362 high-affinity sodium:dicarboxylate symporter activity;GO:0017153 sodium:dicarboxylate symporter activity;GO:0005343 organic acid:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015746 citrate transport;GO:0034775 glutathione transmembrane transport;GO:0015810 aspartate transmembrane transport;GO:0006835 dicarboxylic acid transport;GO:0071422 succinate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9Z0Z5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Z2P3-1", "uniprot_id": [ { "id": "TNFL4_RAT", "url": "https://www.uniprot.org/uniprot/Q9Z2P3", "type": "external" } ], "mass": 22190.0, "length": 199, "protein_name": "Tumor necrosis factor ligand superfamily member 4", "gene_name": "Tnfsf4", "organism": "Rat", "refseq_name": "tumor necrosis factor ligand superfamily member 4", "refseq_ac": [ { "id": "NP_446004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_446004", "type": "external" } ], "gene_names_uniprotkb": "Tnfsf4; Ox40l; Txgp1", "gene_names_refseq": "Ox40l; Tnfsf4; Tnlg2b", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L", "protein_names_refseq": "OX40 ligand; tumor necrosis factor (ligand) superfamily, member 4; tumor necrosis factor ligand 2b; tumor necrosis factor ligand superfamily member 4; tumor necrosis factor superfamily member 4", "tax_id": 10116, "disease": "primary pulmonary hypertension (Disease Ontology:DOID:14557); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); myocardial infarction (Disease Ontology:DOID:5844); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (rno:89814); (R-RNO-5669034)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20871162;9790919", "class_list": "", "function": "Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity)., [UniProtKB]; OX40 and OX40L may play a role in the pathogenesis of experimental allegic neuritis., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0048018 receptor ligand activity;GO:0032813 tumor necrosis factor receptor superfamily binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032700 negative regulation of interleukin-17 production;GO:0045626 negative regulation of T-helper 1 cell differentiation;GO:2000570 positive regulation of T-helper 2 cell activation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9Z2P3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13413-1", "uniprot_id": [ { "id": "TNNI1_RAT", "url": "https://www.uniprot.org/uniprot/P13413", "type": "external" } ], "mass": 21724.0, "length": 187, "protein_name": "Troponin I, slow skeletal muscle", "gene_name": "Tnni1", "organism": "Rat", "refseq_name": "troponin I, slow skeletal muscle", "refseq_ac": [ { "id": "NP_058880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_058880", "type": "external" } ], "gene_names_uniprotkb": "Tnni1", "gene_names_refseq": "Tnni1", "protein_names_uniprotkb": "Troponin I, slow skeletal muscle; Troponin I, slow-twitch isoform", "protein_names_refseq": "troponin I type 1 (skeletal, slow); troponin I, skeletal, slow 1; troponin I, slow skeletal muscle", "tax_id": 10116, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); heart disease (Disease Ontology:DOID:114); dilated cardiomyopathy (Disease Ontology:DOID:12930); adenocarcinoma (Disease Ontology:DOID:299)", "pathway": " (rno:29388); (R-RNO-390522)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "12815045;14726477;19507043;22673903;26391394;2760067;28864299;30820991;31981571", "class_list": "", "function": "A novel role is described for cardiac TnI PKA phosphorylation in the rate-dependent enhancement of systolic & diastolic function in vivo & afterload sensitivity of relaxation. This has implications for cardiac failure., [RefSeq, PubMed]; Regular aerobic exercise appeared to have antioxidant effects in the muscle that reduced TNNI1 slow carbonylation and promoted Ca(2+) /calmodulin-dependent protein kinase IIalpha and TNNI1 expression for skeletal muscle contraction regulation, [RefSeq, PubMed]; Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity., [RefSeq, PubMed]; These findings suggest that altered TnI function, due to changes in the distribution of phosphorylated sites, is an early contributor to reduced contractility of the heart., [RefSeq, PubMed]; These results suggest that cTnI(R146G) and cTnI(R21C) blunt PKA modulation of activation and relaxation kinetics by prohibiting cardiac-specific N-terminal interaction with the cTnI inhibitory peptide., [RefSeq, PubMed]; Troponin I interaction with calcium and Troponin C in cardiac muscle, [RefSeq, PubMed]; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Troponin I phosphorylation has a role in protein kinase C-mediated enhanced contractile performance of myocytes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0060048 cardiac muscle contraction;GO:0014883 transition between fast and slow fiber;GO:0055010 ventricular cardiac muscle tissue morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P13413-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19511-1", "uniprot_id": [ { "id": "AT5F1_RAT", "url": "https://www.uniprot.org/uniprot/P19511", "type": "external" } ], "mass": 28869.0, "length": 256, "protein_name": "ATP synthase peripheral stalk subunit b, mitochondrial", "gene_name": "Atp5pb", "organism": "Rat", "refseq_name": "ATP synthase peripheral stalk subunit b, mitochondrial precursor", "refseq_ac": [ { "id": "NP_599192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_599192", "type": "external" } ], "gene_names_uniprotkb": "Atp5pb; Atp5f1; Atp5f", "gene_names_refseq": "Atp5f1; Atp5pb", "protein_names_uniprotkb": "ATP synthase peripheral stalk subunit b, mitochondrial; ATP synthase F(0) complex subunit B1, mitochondrial; ATP synthase peripheral stalk-membrane subunit b; ATP synthase subunit b; ATPase subunit b", "protein_names_refseq": "ATP synthase F(0) complex subunit B1, mitochondrial; ATP synthase peripheral stalk subunit b, mitochondrial precursor; ATP synthase peripheral stalk subunit b, mitochondrial; ATP synthase subunit b, mitochondrial-like; ATP synthase subunit b, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b; ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1; ATPase subunit b", "tax_id": 10116, "disease": "clear cell renal cell carcinoma (Disease Ontology:DOID:4467); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (rno:171375); (R-RNO-163210); (R-RNO-8949613)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "17575325;2140936;27213235;34502162;38843836", "class_list": "", "function": "Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0015078 proton transmembrane transporter activity;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0071456 cellular response to hypoxia;GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P19511-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D3ZND0-1", "uniprot_id": [ { "id": "UVSSA_RAT", "url": "https://www.uniprot.org/uniprot/D3ZND0", "type": "external" } ], "mass": 82035.0, "length": 720, "protein_name": "UV-stimulated scaffold protein A", "gene_name": "Uvssa", "organism": "Rat", "refseq_name": "UV-stimulated scaffold protein A", "refseq_ac": [ { "id": "NP_001423889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423889", "type": "external" } ], "gene_names_uniprotkb": "Uvssa", "gene_names_refseq": "RGD1306371; Uvssa", "protein_names_uniprotkb": "UV-stimulated scaffold protein A", "protein_names_refseq": "UV-stimulated scaffold protein A", "tax_id": 10116, "disease": "UV-sensitive syndrome (Disease Ontology:DOID:0060240)", "pathway": " (rno:314061); (R-RNO-6781823); (R-RNO-6782135); (R-RNO-6782210)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "22673903;8889548", "class_list": "", "function": "Factor involved in transcription-coupled nucleotide excision repair (TC-NER), a mechanism that rapidly removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. Acts as a key adapter that promotes recruitment of factors involved in TC-NER. Facilitates the ubiquitination of the elongating form of RNA polymerase II (RNA pol IIo) at DNA damage sites, thereby promoting RNA pol IIo backtracking and access by the TC-NER machinery to lesion sites. Also promotes stabilization of ERCC6/CSB by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Mediates the recruitment of the TFIIH complex and other factors that are required for nucleotide excision repair to RNA polymerase II. Also required to inactivate stalled RNA polymerase II by blocking the access of TCEA1/TFIIS, thereby preventing reactivation of RNA polymerase II. Not involved in processing oxidative damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding;GO:0140463 chromatin-protein adaptor activity;GO:0140870 RNA polymerase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0090734 site of DNA damage", "go_biological_process": "GO:0009411 response to UV;GO:0016567 protein ubiquitination;GO:0006283 transcription-coupled nucleotide-excision repair;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "D3ZND0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O54858-1", "uniprot_id": [ { "id": "CBPZ_RAT", "url": "https://www.uniprot.org/uniprot/O54858", "type": "external" } ], "mass": 73082.0, "length": 652, "protein_name": "Carboxypeptidase Z", "gene_name": "Cpz", "organism": "Rat", "refseq_name": "carboxypeptidase Z precursor", "refseq_ac": [ { "id": "NP_113954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_113954", "type": "external" } ], "gene_names_uniprotkb": "Cpz", "gene_names_refseq": "Cpz", "protein_names_uniprotkb": "Carboxypeptidase Z; 3.4.17.-; CPZ", "protein_names_refseq": "carboxypeptidase Z precursor", "tax_id": 10116, "disease": "", "pathway": " (rno:83575)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10671522;12419858;18847325;9570147", "class_list": "", "function": "Specifically cleaves substrates and peptides with C-terminal basic amino acids, especially those containing C-terminal Arg residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data indicate that thyroid hormone may regulate terminal differentiation of growth plate chondrocytes in part by modulating Wnt signaling pathways through the induction of CPZ and subsequent CPZ-enhanced activation of Wnt-4., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O54859", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004180 carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016485 protein processing;GO:0006518 peptide metabolic process;GO:0016055 Wnt signaling pathway;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O54858-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18280-1", "uniprot_id": [ { "id": "NTF3_RAT", "url": "https://www.uniprot.org/uniprot/P18280", "type": "external" } ], "mass": 29645.0, "length": 258, "protein_name": "Neurotrophin-3", "gene_name": "Ntf3", "organism": "Rat", "refseq_name": "neurotrophin-3 isoform 2 precursor", "refseq_ac": [ { "id": "NP_001257797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257797", "type": "external" } ], "gene_names_uniprotkb": "Ntf3; Ntf-3", "gene_names_refseq": "Ntf3", "protein_names_uniprotkb": "Neurotrophin-3; HDNF; NGF-2; NT-3; Nerve growth factor 2; Neurotrophic factor", "protein_names_refseq": "HDNF; NGF-2; NT-3; nerve growth factor 2; neurotrophic factor; neurotrophin-3 (HDNF/NT-3); neurotrophin-3 isoform 2 precursor", "tax_id": 10116, "disease": "atrial heart septal defect 1 (Disease Ontology:DOID:0110106); Alzheimer's disease (Disease Ontology:DOID:10652); hydrocephalus (Disease Ontology:DOID:10908); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); borna disease (Disease Ontology:DOID:5154); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (rno:81737); (R-RNO-1257604); (R-RNO-6811558); (R-RNO-9034013); (R-RNO-9034793); (R-RNO-9603381)", "pathway_count": 6, "publication_count": 9, "publication_id_list": "1889806;2025430;2164684;2321006;32548984;33121345;33763978;38211776;38372112", "class_list": "", "function": "Controlling the Release of Neurotrophin-3 and Chondroitinase ABC Enhances the Efficacy of Nerve Guidance Conduits., [RefSeq, PubMed]; Electroacupuncture facilitates the integration of a grafted TrkC-modified mesenchymal stem cell-derived neural network into transected spinal cord in rats via increasing neurotrophin-3., [RefSeq, PubMed]; Governor Vessel Electro-Acupuncture Promotes the Intrinsic Growth Ability of Spinal Neurons through Activating Calcitonin Gene-Related Peptide/alpha-Calcium/Calmodulin-Dependent Protein Kinase/Neurotrophin-3 Pathway after Spinal Cord Injury., [RefSeq, PubMed]; Neurotrophin-3 into the insular cortex strengthens conditioned taste aversion memory., [RefSeq, PubMed]; Repair effect of neurotrophic factor III (NT-3) on rats with spinal injury model and its mechanism. Publication Status: Online-Only, [RefSeq, PubMed]; Seems to promote the survival of visceral and proprioceptive sensory neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NS33", "ec_number_list": [], "go_molecular_function": "GO:0048406 nerve growth factor binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding;GO:0005165 neurotrophin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031410 cytoplasmic vesicle;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0045687 positive regulation of glial cell differentiation;GO:0042490 mechanoreceptor differentiation;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007274 neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P18280-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35141-1", "uniprot_id": [ { "id": "RASF5_RAT", "url": "https://www.uniprot.org/uniprot/O35141", "type": "external" } ], "mass": 46680.0, "length": 413, "protein_name": "Ras association domain-containing protein 5", "gene_name": "Rassf5", "organism": "Rat", "refseq_name": "ras association domain-containing protein 5", "refseq_ac": [ { "id": "NP_062238", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_062238", "type": "external" } ], "gene_names_uniprotkb": "Rassf5; Nore1", "gene_names_refseq": "Maxp1; Nore1; Rassf5", "protein_names_uniprotkb": "Ras association domain-containing protein 5; Maxp1; New ras effector 1", "protein_names_refseq": "Ras association (RalGDS/AF-6) domain family member 5; new ras effector 1; novel ras effector 1; protein interacting with guanine nucleotide exchange factor; ras association domain-containing protein 5", "tax_id": 10116, "disease": "lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (rno:54355)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12676952;21938476;22673903;24165023", "class_list": "", "function": "Apoptotic Ras effector molecules RASSF1 and NORE1 play important role in NGF reduction and TNF-alpha-related pancreatic beta cell apoptosis in hyperglycemic rats., [RefSeq, PubMed]; Nore1 is a member of a family of Ras effector/tumor suppressors that includes RASSF1, [RefSeq, PubMed]; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis (By similarity)., [UniProtKB]; Specific activation of Rap1B contributes to neuronal polarization via interaction with RalA and Nore1A in addition to PI3-kinase., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0031398 positive regulation of protein ubiquitination;GO:1900180 regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O35141-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O08617-1", "uniprot_id": [ { "id": "PTPRR_RAT", "url": "https://www.uniprot.org/uniprot/O08617", "type": "external" } ], "mass": 73907.0, "length": 656, "protein_name": "Receptor-type tyrosine-protein phosphatase R", "gene_name": "Ptprr", "organism": "Rat", "refseq_name": "receptor-type tyrosine-protein phosphatase R isoform 2", "refseq_ac": [ { "id": "NP_001106861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106861", "type": "external" } ], "gene_names_uniprotkb": "Ptprr; Ptp", "gene_names_refseq": "PC12-PTP1; Pcptp1; Ptprr; R-PTP-R", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase R; 3.1.3.48; PC12-PTP1; Protein-tyrosine phosphatase PCPTP1; R-PTP-R; Tyrosine phosphatase CBPTP", "protein_names_refseq": "protein-tyrosine phosphatase PCPTP1; receptor-type tyrosine-protein phosphatase R isoform 2; receptor-type tyrosine-protein phosphatase R; tyrosine phosphatase CBPTP", "tax_id": 10116, "disease": "", "pathway": " (rno:94202)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7557444;7814416", "class_list": "", "function": "Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q62695;Q63419", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" } ], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0012505 endomembrane system", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O08617-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000000000001000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A5R1-1", "uniprot_id": [ { "id": "RFOX2_RAT", "url": "https://www.uniprot.org/uniprot/A1A5R1", "type": "external" } ], "mass": 45550.0, "length": 432, "protein_name": "RNA binding protein fox-1 homolog 2", "gene_name": "Rbfox2", "organism": "Rat", "refseq_name": "RNA binding protein fox-1 homolog 2 isoform 2", "refseq_ac": [ { "id": "NP_001073364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073364", "type": "external" } ], "gene_names_uniprotkb": "Rbfox2; Fox2; Rbm9", "gene_names_refseq": "Rbfox2; Rbm9", "protein_names_uniprotkb": "RNA binding protein fox-1 homolog 2; Fox-1 homolog B; RNA-binding motif protein 9; RNA-binding protein 9", "protein_names_refseq": "RNA binding protein fox-1 homolog 2 isoform 2; RNA binding protein, fox-1 homolog 2; RNA-binding motif protein 9; RNA-binding protein 9; RNA-binding protein FOX2; fox-1 homolog B", "tax_id": 10116, "disease": "intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); congenital heart disease (Disease Ontology:DOID:1682); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (rno:362950); (R-RNO-6803529)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "34022289;34731606;37415128;37548402", "class_list": "", "function": "Dysregulated Rbfox2 produces aberrant splicing of CaV1.2 calcium channel in diabetes-induced cardiac hypertrophy. Publication Status: Online-Only, [RefSeq, PubMed]; RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts., [RefSeq, PubMed]; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity). Together with RNA binding proteins RBPMS and MBNL1/2, activates vascular smooth muscle cells alternative splicing events (PubMed:37548402)., [UniProtKB, PubMed]; RNA-binding protein that regulates alternative splicing events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Rbfox2 mediates exon 11 inclusion in insulin receptor pre-mRNA splicing in hepatoma cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0003714 transcription corepressor activity;GO:0003727 single-stranded RNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:1904385 cellular response to angiotensin;GO:1902631 negative regulation of membrane hyperpolarization;GO:1990859 cellular response to endothelin;GO:0010724 regulation of definitive erythrocyte differentiation;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1A5R1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O35509-1", "uniprot_id": [ { "id": "RB11B_RAT", "url": "https://www.uniprot.org/uniprot/O35509", "type": "external" } ], "mass": 24489.0, "length": 218, "protein_name": "Ras-related protein Rab-11B", "gene_name": "Rab11b", "organism": "Rat", "refseq_name": "ras-related protein Rab-11B", "refseq_ac": [ { "id": "NP_116006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116006", "type": "external" } ], "gene_names_uniprotkb": "Rab11b", "gene_names_refseq": "Rab11b", "protein_names_uniprotkb": "Ras-related protein Rab-11B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-11B", "tax_id": 10116, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); intestinal cancer (Disease Ontology:DOID:10155)", "pathway": " (rno:79434); (R-RNO-8854214); (R-RNO-8873719)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "14627637;23612789", "class_list": "", "function": "Data indicate that internalized dopamine transporter (DAT) colocalized with GFP-Rab11 and suggest that Rab11 plays an important role in the recycling of DAT following AMPH-induced DAT down-regulation., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth. Also interacts with RABL3 to promote ciliary vesicle formation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9ET14", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0031489 myosin V binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0055037 recycling endosome;GO:0031410 cytoplasmic vesicle;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0045054 constitutive secretory pathway;GO:0045055 regulated exocytosis;GO:0001881 receptor recycling;GO:0032456 endocytic recycling;GO:0032402 melanosome transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O35509-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21677-1", "uniprot_id": [ { "id": "TFE2_RAT", "url": "https://www.uniprot.org/uniprot/P21677", "type": "external" } ], "mass": 67655.0, "length": 649, "protein_name": "Transcription factor E2-alpha", "gene_name": "Tcf3", "organism": "Rat", "refseq_name": "transcription factor E2-alpha isoform b", "refseq_ac": [ { "id": "NP_001030314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030314", "type": "external" } ], "gene_names_uniprotkb": "Tcf3; Pan; Ptf1c; Tcfe2a", "gene_names_refseq": "Pan2; Tcf3; Tcfe2a", "protein_names_uniprotkb": "Transcription factor E2-alpha; Immunoglobulin enhancer-binding factor E12/E47; Pancreas specific transcription factor 1c; TCF-3; Transcription factor 3; Transcription regulator Pan", "protein_names_refseq": "TCF-3; immunoglobulin enhancer-binding factor E12/E47; pancreas specific transcription factor 1c; transcription factor E2-alpha isoform b; transcription factor E2-alpha; transcription factor E2a-like; transcription factor E2a; transcription regulator Pan", "tax_id": 10116, "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); Pitt-Hopkins syndrome (Disease Ontology:DOID:0060488); agammaglobulinemia 8A (Disease Ontology:DOID:0081140); agammaglobulinemia 8B (Disease Ontology:DOID:0081143); prostate cancer (Disease Ontology:DOID:10283); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (rno:171046); (R-RNO-525793); (R-RNO-8939236)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1766666;2200736;22673903;32309849;9013644", "class_list": "", "function": "Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity., [UniProtKB, UniProtKB]; Mechanical stimulation induced osteogenic differentiation of BMSCs through TWIST/E2A/p21 axis., [RefSeq, PubMed]; Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to the consensus sequence CAC/GCTGT/C present, in the chymotrypsin, insulin, AP-4, and several other gene enhancer motifs (PubMed:2200736)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P21676;Q08440;Q4VY47", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P21677-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O70196-1", "uniprot_id": [ { "id": "PPCE_RAT", "url": "https://www.uniprot.org/uniprot/O70196", "type": "external" } ], "mass": 80742.0, "length": 710, "protein_name": "Prolyl endopeptidase", "gene_name": "Prep", "organism": "Rat", "refseq_name": "prolyl endopeptidase", "refseq_ac": [ { "id": "NP_112614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112614", "type": "external" } ], "gene_names_uniprotkb": "Prep", "gene_names_refseq": "Prep; rPop", "protein_names_uniprotkb": "Prolyl endopeptidase; 3.4.21.26; PE; Post-proline cleaving enzyme; rPop", "protein_names_refseq": "PE; post-proline cleaving enzyme; prolyl endopeptidase", "tax_id": 10116, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (rno:83471)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10766975;11792464;14986307;15037553;24288747;30380361;30627904;34225593;37046989", "class_list": "", "function": "Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has high activity on the succinyl- (suc-) peptide-4-methylcoumaryl-7-amide (MCA) substrates suc-Gly-Pro-Leu-Gly-Pro-MCA, suc-Gly-Pro-MCA and suc-Ala-Ala-Ala-MCA., [UniProtKB, PubMed]; Frontal cortex prolyl endopeptidase levels are reduced following benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine treatment in a rat model of depressive syndrome., [RefSeq, PubMed]; In mitotic phases, PREP shares its localization with tubulin in Sertoli cells, gonocytes, and spermatogonia., [RefSeq, PubMed]; Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia. Publication Status: Online-Only, [RefSeq, PubMed]; Long-Term Social Isolation Reduces Expression of the BDNF Precursor and Prolyl Endopeptidase in the Rat Brain., [RefSeq, PubMed]; Prolyl endopeptidase is actually involved in the inactivation of regulatory neuropeptides., [RefSeq, PubMed]; Prolyl oligopeptidase is the main enzyme responsible for synthesis of the antifibrotic peptide Ac-SDKP., [RefSeq, PubMed]; The data indicated the involvement of genes associated with the serotoninergic system in the mechanisms of mental disorders induced by post-weaning social isolation and suggest the gene encoding prolyl endopeptidase as a candidate gene involved in the pathogenesis of these disorders., [RefSeq, PubMed]; The regional distribution of Prep in rat brain was more homogeneous than in humans, and higher than in peripheral tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0004181 metallocarboxypeptidase activity;GO:0042277 peptide binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002003 angiotensin maturation;GO:0030163 protein catabolic process;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O70196-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24050-1", "uniprot_id": [ { "id": "RS5_RAT", "url": "https://www.uniprot.org/uniprot/P24050", "type": "external" } ], "mass": 22878.0, "length": 204, "protein_name": "Small ribosomal subunit protein uS7", "gene_name": "Rps5", "organism": "Rat", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rps5", "gene_names_refseq": "", "protein_names_uniprotkb": "Small ribosomal subunit protein uS7; 40S ribosomal protein S5", "protein_names_refseq": "", "tax_id": 10116, "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)", "pathway": " (rno:25538); (R-RNO-156827); (R-RNO-1799339); (R-RNO-6791226); (R-RNO-72649); (R-RNO-72689); (R-RNO-72695); (R-RNO-72702); (R-RNO-72706); (R-RNO-975956); (R-RNO-975957); (R-RNO-9954714); (R-RNO-9954716)", "pathway_count": 13, "publication_count": 3, "publication_id_list": "1460027;36038000;38843836", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome;GO:0003723 RNA binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0045202 synapse;GO:0005840 ribosome;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0006412 translation;GO:0042274 ribosomal small subunit biogenesis;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P24050-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000000000001000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D4ABB8-1", "uniprot_id": [ { "id": "ATP9B_RAT", "url": "https://www.uniprot.org/uniprot/D4ABB8", "type": "external" } ], "mass": 129178.0, "length": 1147, "protein_name": "Probable phospholipid-transporting ATPase IIB", "gene_name": "Atp9b", "organism": "Rat", "refseq_name": "probable phospholipid-transporting ATPase IIB", "refseq_ac": [ { "id": "NP_001099600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099600", "type": "external" } ], "gene_names_uniprotkb": "Atp9b", "gene_names_refseq": "Atp9b", "protein_names_uniprotkb": "Probable phospholipid-transporting ATPase IIB; 7.6.2.1; ATPase class II type 9B", "protein_names_refseq": "ATPase phospholipid transporting 9B (putative); ATPase, class II, type 9B; probable phospholipid-transporting ATPase IIB", "tax_id": 10116, "disease": "", "pathway": " (rno:291411); (R-RNO-936837)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005802 trans-Golgi network;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006897 endocytosis;GO:0045332 phospholipid translocation;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0015914 phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D4ABB8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000000000000001000.0000000000000.000.00000", "kg_view_protein": true } ]